NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|17563652|ref|NP_503314|]
View 

Seven TM Receptor [Caenorhabditis elegans]

Protein Classification

class R serpentine receptor( domain architecture ID 10563422)

class R serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 5-317 2.87e-89

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402099  Cd Length: 307  Bit Score: 270.48  E-value: 2.87e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563652     5 STLILNLSAVCAVLINFLLIVLILKKSPKSLGSYKFLMLYINLFEFSYAILYFAEKPDLFTKKSAFFLIVNWKESIFPAT 84
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563652    85 MSCLMDLLFVGFFGTSMSILALHFIYRFFSVTNSRYLKIFDSWLIIPIFTVPLINGVLYMITGGIILSADAETDRFMREN 164
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563652   165 YLKVikNQTNLEDLYYMGPFFWPKLENsiTETYFSWKGAEGSLIVMGSIGLSSSIMIFFGIKGYISMNNLLAITsnSEQF 244
Cdd:pfam10326 161 LLEN--YNLDIDEVAYVGPVYYPTDEN--GSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLG--SEKT 234

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17563652   245 QNIQKQLFQALCIQTIIPVVLMHIPASAIYITIFFEKSSVIVGETLSLTIAMYPAMNPLPTIYIVQSYRKAVK 317
Cdd:pfam10326 235 RKLQKQLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 5-317 2.87e-89

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 270.48  E-value: 2.87e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563652     5 STLILNLSAVCAVLINFLLIVLILKKSPKSLGSYKFLMLYINLFEFSYAILYFAEKPDLFTKKSAFFLIVNWKESIFPAT 84
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563652    85 MSCLMDLLFVGFFGTSMSILALHFIYRFFSVTNSRYLKIFDSWLIIPIFTVPLINGVLYMITGGIILSADAETDRFMREN 164
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563652   165 YLKVikNQTNLEDLYYMGPFFWPKLENsiTETYFSWKGAEGSLIVMGSIGLSSSIMIFFGIKGYISMNNLLAITsnSEQF 244
Cdd:pfam10326 161 LLEN--YNLDIDEVAYVGPVYYPTDEN--GSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLG--SEKT 234

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17563652   245 QNIQKQLFQALCIQTIIPVVLMHIPASAIYITIFFEKSSVIVGETLSLTIAMYPAMNPLPTIYIVQSYRKAVK 317
Cdd:pfam10326 235 RKLQKQLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 5-317 2.87e-89

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 270.48  E-value: 2.87e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563652     5 STLILNLSAVCAVLINFLLIVLILKKSPKSLGSYKFLMLYINLFEFSYAILYFAEKPDLFTKKSAFFLIVNWKESIFPAT 84
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563652    85 MSCLMDLLFVGFFGTSMSILALHFIYRFFSVTNSRYLKIFDSWLIIPIFTVPLINGVLYMITGGIILSADAETDRFMREN 164
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563652   165 YLKVikNQTNLEDLYYMGPFFWPKLENsiTETYFSWKGAEGSLIVMGSIGLSSSIMIFFGIKGYISMNNLLAITsnSEQF 244
Cdd:pfam10326 161 LLEN--YNLDIDEVAYVGPVYYPTDEN--GSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLG--SEKT 234

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17563652   245 QNIQKQLFQALCIQTIIPVVLMHIPASAIYITIFFEKSSVIVGETLSLTIAMYPAMNPLPTIYIVQSYRKAVK 317
Cdd:pfam10326 235 RKLQKQLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 11-316 1.98e-23

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 98.47  E-value: 1.98e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563652    11 LSAVCAVLINFLLIVLILKKSPKSLGSYKFLMLYINLFEFSYAILYFAEKPDLFTKKSAFFLIVNWKESIFPATMSCLMD 90
Cdd:pfam10319  13 IFGVLSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFVSDGPFFEYSELGQHAL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563652    91 LLFVGFFGTSMSILALHFIYRFFSVTNSRYL-KIFDSWLIIPIFTVPLINGVLYMITGGIILSADAETDRFMRENYLKVI 169
Cdd:pfam10319  93 SARCSFISASYAVLLIHFIYRYLVLFNPQLTrHYFRPWGILISILFFLFHGSVWTAICYFLLRANDEIRDYIREDFRETY 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563652   170 KNQTNleDLYYMGPFFWpklENSITETYFSWKGaegslIVMGSIgLSSSIMIFFGIKGYISMNNLLAITSN-SEQFQNIQ 248
Cdd:pfam10319 173 GVDSM--DINMLGALYW---EASDETVFRSWLG-----ILLLTV-ISVYSIILYIVLGYKIMRKLNKMSVTmSKKTKRLQ 241

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17563652   249 KQLFQALCIQTIIPVVLMHIPAS-AIYITIFFEKSSVIVGETLSLTIAMYPAMNPLPTIYIVQSYRKAV 316
Cdd:pfam10319 242 KQLLKALIVQTIIPICISFSPCVlAWYSPIFGIDLGRWNNYLEVIALSAFPFIDPLAIILCLPVYRNRI 310
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 13-317 9.75e-11

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 61.80  E-value: 9.75e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563652    13 AVCAVLINFLLIVLILKKSPKSLGSYKFLMLYINLFEFSYAILYFAEKPDLFTKKSAFFLIVNWKESIFPATMSCLMDLL 92
Cdd:pfam10317   9 FILGLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQRIIPNGVSMALISYGPCKYFGPWFCYSGYSL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563652    93 FVGFFGTSMSILALHFIYRFFSVTNSRylkiFDSWLIIPIFTVPLINGVLYMITggIILSadaETDRFMRENYLKVIKNQ 172
Cdd:pfam10317  89 LQHFLLHSGWSLLLTFYYRYYILKHVD----PKRKKLILLIIIHYIPSLSQLIV--IFLS---PTDFLPVEALTKELHPN 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563652   173 TNLEDLYYMGpffwpklensiTETYFSWKGAEGSLIVMGSIGLSSSIMIFFGIKGYISMNNLLAITSNSEQFQNiqKQLF 252
Cdd:pfam10317 160 YNLTDYTVTG-----------FSDLQSFPALINTLIMTIPVFPIPIIILILRRKILKLLNSNSVNMSPTTKAQH--RQLI 226

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17563652   253 QALCIQTIIPvVLMHIPASAIYITIFFEKSSVIVGETLSLTIAMYPAM-NPLPTIYIVQSYRKAVK 317
Cdd:pfam10317 227 KGLTIQALLP-LFSYIPGVTLYLLSQLTGTEFLILEYFIFVLPALPPLlDPLITIYFVTPYRRAIL 291
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 6-320 5.38e-09

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 56.78  E-value: 5.38e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563652     6 TLILNLSAVCAVLINFLLIVLILKKSPKSLGSYKFLMLYIN----LFEFSYAILyfaEKPDLFTKKSAFFLIVNWKESIF 81
Cdd:pfam10318   7 STSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHfwsaLLDLSLSFL---TIPYIFLPALAGYPLGLLSYLGV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563652    82 PAtmSCLMDLLFVGFFGTSMSILALhFIYRFFSVTNSRYlKIFDSWLIIPIFTVPLINGVLYMITGGIILSADAETDRFM 161
Cdd:pfam10318  84 PT--PIQFYIGVTSLALVGVSIILL-FENRYSILFTNKK-RITWKKTRVLYLIFNYIIALLFLIPIYLNIPDQEAAKLKV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563652   162 RENYLKVIKNQTNLEDLYYMgpffwpklenSITETYFSWkgaegSLIVMGSIGLSSSIMIFFGIKGYISMNNLLAItsnS 241
Cdd:pfam10318 160 LKKLPCLPPEFFDNPPVFVL----------AIDSTYFLI-----CIVLLILILIIQILFFVFLTIYYLFKSVKSSL---S 221

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17563652   242 EQFQNIQKQLFQALCIQTIIPVVLMHIPASAIYITIFFEKSSVIVGETLSLTIAMYPAMNPLPTIYIVQSYRKAVKDYF 320
Cdd:pfam10318 222 KKTRKLQKKFFIALIIQVSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLF 300
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH