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Conserved domains on  [gi|71995092|ref|NP_503277|]
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CHK kinase-like domain-containing protein [Caenorhabditis elegans]

Protein Classification

choline kinase family protein( domain architecture ID 10546060)

choline kinase family protein belonging to the protein kinase superfamily

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF1679 pfam07914
Uncharacterized oxidoreductase dhs-27; The region featured in this family is found in a number ...
 10-421 0e+00

Uncharacterized oxidoreductase dhs-27; The region featured in this family is found in a number of C. elegans proteins, in one case as a repeat. In many of the family members, this region is associated with the CHK region described by SMART as being found in ZnF_C4 and HLH domain-containing kinases. In fact, one member of this family is annotated as being a member of the nuclear hormone receptor family, and contains regions typical of such proteins (Interpro:IPR000536, Interpro:IPR008946, and Interpro:IPR001628).


:

Pssm-ID: 369592  Cd Length: 413  Bit Score: 575.38  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71995092    10 ILDIGDGLFQTHVQLEDVQKVIGEQMNTKARLGENTKYTVIGDGNGFSSRVILVEPEWTVS--DKHLPEKFVLKITSCLH 87
Cdd:pfam07914   1 LYEPADGLLETHVTWEDVEKAIQEQLGTEAKFGENKKATNIGDGKGFMSRIALIEPDWTNVepSKNLPKKFALKISSQLH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71995092    88 VPGLIEQMKGKNPGTFPAQEAalWAIFENEAQKLHNREVNLYKITEKWNkNETMLSPKIYFYKKFDAENKTKGILGMEFD 167
Cdd:pfam07914  81 LIALSKKMKFEGGNGFTEEKE--LKHFEKSTRELHNREVNFYKILEKFN-HPDIPFTKVYFLKKFDDENDLKGYIIMEYV 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71995092   168 GNVTVRHIYCNVKPRELYPVLRSIATLQAGSLHLTKDEIESISGLD-VKQMMGSLMNNEGMKGFYEQTREIN----RKRL 242
Cdd:pfam07914 158 PNIHTRHMYENIPADELIPVLRAIATFQALGESLSEEEKKSANGADfLEEMFETFMSEEGLKGIFEQLRNIFgaayPEKV 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71995092   243 TEKTNVVEAFGQEVVNFELACNLNKYIGIKrDVMVHGDLWAANILWKEKDEGTFSVSKVIDYQLIHMGNPAEDLVRLFLS 322
Cdd:pfam07914 238 EELVDIFEHYGPEILIFKKYTNLNKVLGIK-PVLVHGDLWQSNILWTLENDGKLKLKAIIDYQTVHMGNPAEDLVRLLLS 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71995092   323 TLSGADRQAHWERLLEKFYTYFLAALGDDEAPYSLEQLKECYRCFFVSGGLVMMPMYGPFAQAKlsyLKDIESVQEYQEI 402
Cdd:pfam07914 317 CLSGADRRAHWEELLEQYYETFTKALGDNEEPYTLEQLKDSYNLYFPMMSLLLLPLIGPFLDMK---SMSEEEKEEYREV 393

                         410
                  ....*....|....*....
gi 71995092   403 LTEKAEHLMEDLERWHLYS 421
Cdd:pfam07914 394 VIEKMEALLEDLIKVHEYN 412
 
Name Accession Description Interval E-value
DUF1679 pfam07914
Uncharacterized oxidoreductase dhs-27; The region featured in this family is found in a number ...
 10-421 0e+00

Uncharacterized oxidoreductase dhs-27; The region featured in this family is found in a number of C. elegans proteins, in one case as a repeat. In many of the family members, this region is associated with the CHK region described by SMART as being found in ZnF_C4 and HLH domain-containing kinases. In fact, one member of this family is annotated as being a member of the nuclear hormone receptor family, and contains regions typical of such proteins (Interpro:IPR000536, Interpro:IPR008946, and Interpro:IPR001628).


Pssm-ID: 369592  Cd Length: 413  Bit Score: 575.38  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71995092    10 ILDIGDGLFQTHVQLEDVQKVIGEQMNTKARLGENTKYTVIGDGNGFSSRVILVEPEWTVS--DKHLPEKFVLKITSCLH 87
Cdd:pfam07914   1 LYEPADGLLETHVTWEDVEKAIQEQLGTEAKFGENKKATNIGDGKGFMSRIALIEPDWTNVepSKNLPKKFALKISSQLH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71995092    88 VPGLIEQMKGKNPGTFPAQEAalWAIFENEAQKLHNREVNLYKITEKWNkNETMLSPKIYFYKKFDAENKTKGILGMEFD 167
Cdd:pfam07914  81 LIALSKKMKFEGGNGFTEEKE--LKHFEKSTRELHNREVNFYKILEKFN-HPDIPFTKVYFLKKFDDENDLKGYIIMEYV 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71995092   168 GNVTVRHIYCNVKPRELYPVLRSIATLQAGSLHLTKDEIESISGLD-VKQMMGSLMNNEGMKGFYEQTREIN----RKRL 242
Cdd:pfam07914 158 PNIHTRHMYENIPADELIPVLRAIATFQALGESLSEEEKKSANGADfLEEMFETFMSEEGLKGIFEQLRNIFgaayPEKV 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71995092   243 TEKTNVVEAFGQEVVNFELACNLNKYIGIKrDVMVHGDLWAANILWKEKDEGTFSVSKVIDYQLIHMGNPAEDLVRLFLS 322
Cdd:pfam07914 238 EELVDIFEHYGPEILIFKKYTNLNKVLGIK-PVLVHGDLWQSNILWTLENDGKLKLKAIIDYQTVHMGNPAEDLVRLLLS 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71995092   323 TLSGADRQAHWERLLEKFYTYFLAALGDDEAPYSLEQLKECYRCFFVSGGLVMMPMYGPFAQAKlsyLKDIESVQEYQEI 402
Cdd:pfam07914 317 CLSGADRRAHWEELLEQYYETFTKALGDNEEPYTLEQLKDSYNLYFPMMSLLLLPLIGPFLDMK---SMSEEEKEEYREV 393

                         410
                  ....*....|....*....
gi 71995092   403 LTEKAEHLMEDLERWHLYS 421
Cdd:pfam07914 394 VIEKMEALLEDLIKVHEYN 412
CHK smart00587
ZnF_C4 abd HLH domain containing kinases domain; subfamily of choline kinases
 161-350 6.18e-48

ZnF_C4 abd HLH domain containing kinases domain; subfamily of choline kinases


Pssm-ID: 214734  Cd Length: 196  Bit Score: 162.50  E-value: 6.18e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71995092    161 ILGMEFDGNVTVRHIYCNVKPRELY-PVLRSIATLQAGSLHLTKDEIESISGLDVK---QMMGSLMNNEGMKGFYEQTRE 236
Cdd:smart00587   1 IIFEDLSPKGYVNADRLKGLDLEHTsLVLKKLAKLHAASAVLIEEEKGSYLEEFDEglfERFKRMFSEEFIGGLENFLRE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71995092    237 INR-KRLTEKTNVVEAFGQEVVNFELACNLNKYIGIKR-DVMVHGDLWAANILWKEKDEGTFSVSKVIDYQLIHMGNPAE 314
Cdd:smart00587  81 LLSqPELLKVEEYIEKLDKLLDNLEDLKKEDKEPDEGEfNVLNHGDLWANNIMFKYDDEGKPEDVALIDFQLSHYGSPAE 160

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 71995092    315 DLVRLFLSTLSGADRQAHWERLLEKFYTYFLAALGD 350
Cdd:smart00587 161 DLHYFLLTSLSVEIRREHFDELLKFYYETLVETLKK 196
YcbJ COG3173
Predicted kinase, aminoglycoside phosphotransferase (APT) family [General function prediction ...
 273-355 7.62e-08

Predicted kinase, aminoglycoside phosphotransferase (APT) family [General function prediction only];


Pssm-ID: 442406 [Multi-domain]  Cd Length: 284  Bit Score: 53.58  E-value: 7.62e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71995092 273 RDVMVHGDLWAANILWkekDEGTFSVSKVIDYQLIHMGNPAEDLVRLFLSTLSGADRQAHWERLLEkfyTYFLAALGDDE 352
Cdd:COG3173 191 PPVLVHGDLRPGNLLV---DPDDGRLTAVIDWELATLGDPAADLAYLLLYWRLPDDLLGPRAAFLA---AYEEATGDLDD 264


                ...
gi 71995092 353 APY 355
Cdd:COG3173 265 LTW 267
APH_ChoK_like_1 cd05155
Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase and ...
 272-353 1.36e-04

Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase and Choline kinase; This subfamily is composed of uncharacterized bacterial proteins with similarity to APH and ChoK. Other APH/ChoK-like proteins include ethanolamine kinase (ETNK), macrolide 2'-phosphotransferase (MPH2'), an unusual homoserine kinase, and uncharacterized proteins with similarity to the N-terminal domain of acyl-CoA dehydrogenase 10 (ACAD10). These proteins catalyze the transfer of the gamma-phosphoryl group from ATP (or CTP) to small molecule substrates, such as aminoglycosides, macrolides, choline, ethanolamine, and homoserine. Phosphorylation of the antibiotics, aminoglycosides, and macrolides leads to their inactivation and to bacterial antibiotic resistance. Phosphorylation of choline, ethanolamine, and homoserine serves as precursors to the synthesis of important biological compounds, such as the major phospholipids, phosphatidylcholine and phosphatidylethanolamine and the amino acids, threonine, methionine, and isoleucine. The APH/ChoK-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270704 [Multi-domain]  Cd Length: 234  Bit Score: 42.99  E-value: 1.36e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71995092 272 KRDVMVHGDLWAANILwkeKDEGtfSVSKVIDYQLIHMGNPAEDLVRLFLsTLSGADRQAhwerllekfytyFLAALGDD 351
Cdd:cd05155 161 GPPVWLHGDLHPGNLL---VRDG--RLSAVIDFGDLGVGDPACDLAIAWT-LFDAAARAA------------FRAALGVD 222


                ..
gi 71995092 352 EA 353
Cdd:cd05155 223 DA 224
 
Name Accession Description Interval E-value
DUF1679 pfam07914
Uncharacterized oxidoreductase dhs-27; The region featured in this family is found in a number ...
 10-421 0e+00

Uncharacterized oxidoreductase dhs-27; The region featured in this family is found in a number of C. elegans proteins, in one case as a repeat. In many of the family members, this region is associated with the CHK region described by SMART as being found in ZnF_C4 and HLH domain-containing kinases. In fact, one member of this family is annotated as being a member of the nuclear hormone receptor family, and contains regions typical of such proteins (Interpro:IPR000536, Interpro:IPR008946, and Interpro:IPR001628).


Pssm-ID: 369592  Cd Length: 413  Bit Score: 575.38  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71995092    10 ILDIGDGLFQTHVQLEDVQKVIGEQMNTKARLGENTKYTVIGDGNGFSSRVILVEPEWTVS--DKHLPEKFVLKITSCLH 87
Cdd:pfam07914   1 LYEPADGLLETHVTWEDVEKAIQEQLGTEAKFGENKKATNIGDGKGFMSRIALIEPDWTNVepSKNLPKKFALKISSQLH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71995092    88 VPGLIEQMKGKNPGTFPAQEAalWAIFENEAQKLHNREVNLYKITEKWNkNETMLSPKIYFYKKFDAENKTKGILGMEFD 167
Cdd:pfam07914  81 LIALSKKMKFEGGNGFTEEKE--LKHFEKSTRELHNREVNFYKILEKFN-HPDIPFTKVYFLKKFDDENDLKGYIIMEYV 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71995092   168 GNVTVRHIYCNVKPRELYPVLRSIATLQAGSLHLTKDEIESISGLD-VKQMMGSLMNNEGMKGFYEQTREIN----RKRL 242
Cdd:pfam07914 158 PNIHTRHMYENIPADELIPVLRAIATFQALGESLSEEEKKSANGADfLEEMFETFMSEEGLKGIFEQLRNIFgaayPEKV 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71995092   243 TEKTNVVEAFGQEVVNFELACNLNKYIGIKrDVMVHGDLWAANILWKEKDEGTFSVSKVIDYQLIHMGNPAEDLVRLFLS 322
Cdd:pfam07914 238 EELVDIFEHYGPEILIFKKYTNLNKVLGIK-PVLVHGDLWQSNILWTLENDGKLKLKAIIDYQTVHMGNPAEDLVRLLLS 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71995092   323 TLSGADRQAHWERLLEKFYTYFLAALGDDEAPYSLEQLKECYRCFFVSGGLVMMPMYGPFAQAKlsyLKDIESVQEYQEI 402
Cdd:pfam07914 317 CLSGADRRAHWEELLEQYYETFTKALGDNEEPYTLEQLKDSYNLYFPMMSLLLLPLIGPFLDMK---SMSEEEKEEYREV 393

                         410
                  ....*....|....*....
gi 71995092   403 LTEKAEHLMEDLERWHLYS 421
Cdd:pfam07914 394 VIEKMEALLEDLIKVHEYN 412
CHK smart00587
ZnF_C4 abd HLH domain containing kinases domain; subfamily of choline kinases
 161-350 6.18e-48

ZnF_C4 abd HLH domain containing kinases domain; subfamily of choline kinases


Pssm-ID: 214734  Cd Length: 196  Bit Score: 162.50  E-value: 6.18e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71995092    161 ILGMEFDGNVTVRHIYCNVKPRELY-PVLRSIATLQAGSLHLTKDEIESISGLDVK---QMMGSLMNNEGMKGFYEQTRE 236
Cdd:smart00587   1 IIFEDLSPKGYVNADRLKGLDLEHTsLVLKKLAKLHAASAVLIEEEKGSYLEEFDEglfERFKRMFSEEFIGGLENFLRE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71995092    237 INR-KRLTEKTNVVEAFGQEVVNFELACNLNKYIGIKR-DVMVHGDLWAANILWKEKDEGTFSVSKVIDYQLIHMGNPAE 314
Cdd:smart00587  81 LLSqPELLKVEEYIEKLDKLLDNLEDLKKEDKEPDEGEfNVLNHGDLWANNIMFKYDDEGKPEDVALIDFQLSHYGSPAE 160

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 71995092    315 DLVRLFLSTLSGADRQAHWERLLEKFYTYFLAALGD 350
Cdd:smart00587 161 DLHYFLLTSLSVEIRREHFDELLKFYYETLVETLKK 196
EcKL pfam02958
Ecdysteroid kinase-like family; This family includes ecdysteroid 22-kinase, an enzyme ...
 275-348 3.00e-10

Ecdysteroid kinase-like family; This family includes ecdysteroid 22-kinase, an enzyme responsible for the phosphorylation of ecdysteroids (insect growth and moulting hormones) at C-22, to form physiologically inactive ecdysteroid 22-phosphates. Most insects contain 12 to 105 genes encoding this family and yet so far only one enzyme (ecdysteroid 22-kinase from Bombyx mori) has characterized substrates (2-deoxyecdysone, ecdysone, 20-hydroxyecdysone). There are good reasons to believe that this family includes kinases that act on other small molecule substrates and that they may function in detoxification processes.


Pssm-ID: 397213 [Multi-domain]  Cd Length: 293  Bit Score: 60.75  E-value: 3.00e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71995092   275 VMVHGDLWAANILWKEKDEGTFSVSKVIDYQLIHMGNPAEDLVRLFLSTLSGADRQAHWERLLEKFYTYFLAAL 348
Cdd:pfam02958 215 VLNHGDLWVNNIMFKYDDEGEPEDVILVDFQLSRYGSPAIDLNYFLYTSTELELRLEHFDELLRYYHSSLVETL 288
YcbJ COG3173
Predicted kinase, aminoglycoside phosphotransferase (APT) family [General function prediction ...
 273-355 7.62e-08

Predicted kinase, aminoglycoside phosphotransferase (APT) family [General function prediction only];


Pssm-ID: 442406 [Multi-domain]  Cd Length: 284  Bit Score: 53.58  E-value: 7.62e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71995092 273 RDVMVHGDLWAANILWkekDEGTFSVSKVIDYQLIHMGNPAEDLVRLFLSTLSGADRQAHWERLLEkfyTYFLAALGDDE 352
Cdd:COG3173 191 PPVLVHGDLRPGNLLV---DPDDGRLTAVIDWELATLGDPAADLAYLLLYWRLPDDLLGPRAAFLA---AYEEATGDLDD 264


                ...
gi 71995092 353 APY 355
Cdd:COG3173 265 LTW 267
APH pfam01636
Phosphotransferase enzyme family; This family consists of bacterial antibiotic resistance ...
 277-352 2.97e-05

Phosphotransferase enzyme family; This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include: aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation. This family also includes homoserine kinase. This family is related to fructosamine kinase pfam03881.


Pssm-ID: 426359 [Multi-domain]  Cd Length: 239  Bit Score: 45.18  E-value: 2.97e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 71995092   277 VHGDLWAANILWKEKDEgtfsVSKVIDYQLIHMGNPAEDLVRLFlstlsgadrqAHW-ERLLEKFYTYFLAALGDDE 352
Cdd:pfam01636 170 VHGDLHPGNLLVDPGGR----VSGVIDFEDAGLGDPAYDLAILL----------NSWgRELGAELLAAYLAAYGAFG 232
APH_ChoK_like_1 cd05155
Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase and ...
 272-353 1.36e-04

Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase and Choline kinase; This subfamily is composed of uncharacterized bacterial proteins with similarity to APH and ChoK. Other APH/ChoK-like proteins include ethanolamine kinase (ETNK), macrolide 2'-phosphotransferase (MPH2'), an unusual homoserine kinase, and uncharacterized proteins with similarity to the N-terminal domain of acyl-CoA dehydrogenase 10 (ACAD10). These proteins catalyze the transfer of the gamma-phosphoryl group from ATP (or CTP) to small molecule substrates, such as aminoglycosides, macrolides, choline, ethanolamine, and homoserine. Phosphorylation of the antibiotics, aminoglycosides, and macrolides leads to their inactivation and to bacterial antibiotic resistance. Phosphorylation of choline, ethanolamine, and homoserine serves as precursors to the synthesis of important biological compounds, such as the major phospholipids, phosphatidylcholine and phosphatidylethanolamine and the amino acids, threonine, methionine, and isoleucine. The APH/ChoK-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270704 [Multi-domain]  Cd Length: 234  Bit Score: 42.99  E-value: 1.36e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71995092 272 KRDVMVHGDLWAANILwkeKDEGtfSVSKVIDYQLIHMGNPAEDLVRLFLsTLSGADRQAhwerllekfytyFLAALGDD 351
Cdd:cd05155 161 GPPVWLHGDLHPGNLL---VRDG--RLSAVIDFGDLGVGDPACDLAIAWT-LFDAAARAA------------FRAALGVD 222


                ..
gi 71995092 352 EA 353
Cdd:cd05155 223 DA 224
CotS COG0510
Thiamine kinase or a related kinase [Coenzyme transport and metabolism];
275-352 9.79e-04

Thiamine kinase or a related kinase [Coenzyme transport and metabolism];


Pssm-ID: 440276 [Multi-domain]  Cd Length: 156  Bit Score: 39.76  E-value: 9.79e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 71995092 275 VMVHGDLWAANILWKEKDEgtfsvSKVIDYQLIHMGNPAEDLVRLFLSTlsgADRQAHWERLLEkfyTYFLAALGDDE 352
Cdd:COG0510  50 VLCHGDLHPGNFLVTDDGR-----LYLIDWEYAGLGDPAFDLAALLVEY---GLSPEQAEELLE---AYGFGRPTEEL 116
Kdo pfam06293
Lipopolysaccharide kinase (Kdo/WaaP) family; These lipopolysaccharide kinases are related to ...
 278-338 1.41e-03

Lipopolysaccharide kinase (Kdo/WaaP) family; These lipopolysaccharide kinases are related to protein kinases pfam00069. This family includes waaP (rfaP) gene product is required for the addition of phosphate to O-4 of the first heptose residue of the lipopolysaccharide (LPS) inner core region. It has previously been shown that WaaP is necessary for resistance to hydrophobic and polycationic antimicrobials in E. coli and that it is required for virulence in invasive strains of S. enterica.


Pssm-ID: 428872  Cd Length: 206  Bit Score: 39.68  E-value: 1.41e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 71995092   278 HGDLWAANILWKEKDEGTFSVSkVIDY---QLIHMGNPA--EDLVRLFLSTLSGADRQAHWERLLE 338
Cdd:pfam06293 140 HGDLYAHHILLQQEGDEGFEAW-LIDLdkgRLRLPARRWrnKDLARLLRSFLNIGFTEADWERLLR 204
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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