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Conserved domains on  [gi|17563380|ref|NP_503144|]
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Serpentine Receptor, class H [Caenorhabditis elegans]

Protein Classification

class H serpentine receptor( domain architecture ID 10563391)

class H serpentine receptor (Srh) belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans, and is related to the Str, Stl, and Srd families of 7TM serpentine receptors

CATH:  1.20.1070.10
Gene Ontology:  GO:0004888
PubMed:  10673277|23140243

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
23-327 7.56e-104

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402095  Cd Length: 302  Bit Score: 307.55  E-value: 7.56e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563380    23 CSWQGVAYTFHSITVFSIPFYIFGGYCILFKSTSQMGSYRLPLFNFHFWTCLVDIMINALATPYFFFPSLAGFSVGFLNF 102
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563380   103 LGVPPPIQTWLAFQSINLMTMSMTVLLENRHNSIPFNRFKISGKNTKSLYYAIRILLGLSYTLSMLLFIPeDQEAALLQI 182
Cdd:pfam10318  81 LGVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTNKKRITWKKTRVLYLIFNYIIALLFLIPIYLNIP-DQEAAKLKV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563380   183 LRQILCPTKEFFTASGVYVVCIDegyIKFLALFTVLGTLSEICQMAFFVLCCSYYLFFSKSSFTSKKTRKLQIAFFASII 262
Cdd:pfam10318 160 LKKLPCLPPEFFDNPPVFVLAID---STYFLICIVLLILILIIQILFFVFLTIYYLFKSVKSSLSKKTRKLQKKFFIALI 236
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17563380   263 LQISIPITFLLPTFFYLGFSVGFKYYNQALTNLSVLHASLHGLISTFVVLIIHKPYRQFIILIFK 327
Cdd:pfam10318 237 IQVSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFK 301
 
Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
23-327 7.56e-104

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 307.55  E-value: 7.56e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563380    23 CSWQGVAYTFHSITVFSIPFYIFGGYCILFKSTSQMGSYRLPLFNFHFWTCLVDIMINALATPYFFFPSLAGFSVGFLNF 102
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563380   103 LGVPPPIQTWLAFQSINLMTMSMTVLLENRHNSIPFNRFKISGKNTKSLYYAIRILLGLSYTLSMLLFIPeDQEAALLQI 182
Cdd:pfam10318  81 LGVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTNKKRITWKKTRVLYLIFNYIIALLFLIPIYLNIP-DQEAAKLKV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563380   183 LRQILCPTKEFFTASGVYVVCIDegyIKFLALFTVLGTLSEICQMAFFVLCCSYYLFFSKSSFTSKKTRKLQIAFFASII 262
Cdd:pfam10318 160 LKKLPCLPPEFFDNPPVFVLAID---STYFLICIVLLILILIIQILFFVFLTIYYLFKSVKSSLSKKTRKLQKKFFIALI 236
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17563380   263 LQISIPITFLLPTFFYLGFSVGFKYYNQALTNLSVLHASLHGLISTFVVLIIHKPYRQFIILIFK 327
Cdd:pfam10318 237 IQVSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFK 301
 
Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
23-327 7.56e-104

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 307.55  E-value: 7.56e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563380    23 CSWQGVAYTFHSITVFSIPFYIFGGYCILFKSTSQMGSYRLPLFNFHFWTCLVDIMINALATPYFFFPSLAGFSVGFLNF 102
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563380   103 LGVPPPIQTWLAFQSINLMTMSMTVLLENRHNSIPFNRFKISGKNTKSLYYAIRILLGLSYTLSMLLFIPeDQEAALLQI 182
Cdd:pfam10318  81 LGVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTNKKRITWKKTRVLYLIFNYIIALLFLIPIYLNIP-DQEAAKLKV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563380   183 LRQILCPTKEFFTASGVYVVCIDegyIKFLALFTVLGTLSEICQMAFFVLCCSYYLFFSKSSFTSKKTRKLQIAFFASII 262
Cdd:pfam10318 160 LKKLPCLPPEFFDNPPVFVLAID---STYFLICIVLLILILIIQILFFVFLTIYYLFKSVKSSLSKKTRKLQKKFFIALI 236
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17563380   263 LQISIPITFLLPTFFYLGFSVGFKYYNQALTNLSVLHASLHGLISTFVVLIIHKPYRQFIILIFK 327
Cdd:pfam10318 237 IQVSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFK 301
7TM_GPCR_Sri pfam10327
Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis ...
30-322 1.24e-11

Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sri is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 313539  Cd Length: 303  Bit Score: 64.49  E-value: 1.24e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563380    30 YTFHSITVFSIPFYIFGGYCILFKStSQMGSYRLPLFNFHFWTCLVDIMINALATPYFFFPSLAGFSVGFL-NFLGVPPP 108
Cdd:pfam10327  13 LYYHIIGTISLILNLLGIYLIIFKS-GKIDNFRYYLLYFQISCTLTDIHLTFLMQPIPLFPIIAGYCNGFLaTVFGISSH 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563380   109 IQTWLAFQSINLMTMSMTVLLENRHNSIpfNRFKISGKNTKSLYYAIRILLgLSYTLSMLLFI------PEDQeaalLQI 182
Cdd:pfam10327  92 YLMTIFVFLLSFQLESLLLCFVRKHQAI--AKILSKHVIPKWLYIFLYILC-HIFPFLTAFLFyqsglsREEQ----LEY 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563380   183 LRQILCPTKEFFTASGVYVVCIDEGYIKFLALFTVLGTLSEICQMAFFVLCCSYYLFFSKSSFTSKKTRKLQIAFFaSII 262
Cdd:pfam10327 165 VKENYPEYLSQFSSLPNFAIYDYNPWLIVFGILAIFGGSLSFLILVYLTVDMFRMLKRLRKKISAQTYQKHRAALR-SLI 243
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17563380   263 LQISIPITFLLPTFFyLGFSVGFKYYN-QALTNLSVLHASLHGLISTFVVLIIHKPYRQFI 322
Cdd:pfam10327 244 AQFATSPVCILPPFA-FVVVVLFPIEYsQEISEILLAIFSTHSSVNSIVLILTTPPYRKFL 303
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
48-323 1.18e-05

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 46.29  E-value: 1.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563380    48 YCILFKSTSQMGSYRLPLFNFhfwtCLVDIM---INALATPYFFFPSLAGFSVGFLNFLGVPPPIQTWLA--FQSINLMT 122
Cdd:pfam10326  21 YLILFKSPKIFGTYKYLMIYF----SIFGIFfsiLEFIVKPFIHSYNSSFIVFVDLKDLGLSKSVGQILLalYCGFYGVS 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563380   123 MSMTVL--------LENRHNSIPFNRFKISgkntksLYYAIRILLGLSYTLSMLLFIPEDQEA--ALLQILRQILCPTKE 192
Cdd:pfam10326  97 ISLLAVqfiyrylaLCRPGKLKYFDGKKLI------LWFLYPLIFGAIWGLLVYFFLGPDEETdeYLREELLENYNLDID 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17563380   193 FFTASGVYVVCIDEGYIKFLALFTVLGTLSEICQMA---FFVLCCSYYLFF---SKSSFTSKKTRKLQIAFFASIILQIS 266
Cdd:pfam10326 171 EVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGisfSIIIYCGIKMYFkmkKLKSLGSEKTRKLQKQLFKALVIQTL 250
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 17563380   267 IPITFL-LPTFFYLGFSVgFKYYNQALTNLSVLHASLHGLISTFVVLIIHKPYRQFII 323
Cdd:pfam10326 251 IPTILMyIPVGILFLLPL-FNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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