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Conserved domains on  [gi|115534507|ref|NP_503013|]
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Peptidase S54 rhomboid domain-containing protein [Caenorhabditis elegans]

Protein Classification

rhomboid family protein( domain architecture ID 10483871)

rhomboid family protein may be an intramembrane serine protease that catalyzes regulated intramembrane proteolysis, resulting in the release of functional polypeptides from their membrane anchors, or an inactive rhomboid protein that lacks the conserved active sites and has no peptidase activity

CATH:  1.20.1540.10
Gene Ontology:  GO:0016020
MEROPS:  S54
PubMed:  24099005|22035660|26527717|12620104
SCOP:  4000471

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Rhomboid pfam01694
Rhomboid family; This family contains integral membrane proteins that are related to ...
 580-724 3.71e-42

Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.


:

Pssm-ID: 426384  Cd Length: 147  Bit Score: 150.45  E-value: 3.71e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115534507  580 DNPNQIYRLFTSLFIHAGVIHLALSMAFQMYFMAYQENLIGSKRMAILYFASGISGNLASAIFVPY-YPTVGPSSAQCGV 658
Cdd:pfam01694   2 VQPGQLWRLITSMFLHAGWLHLLFNMLALLFFGGPLERILGSVRFLLLYLLSGIAGSLLSYLFSPLsTPSVGASGAIFGL 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 115534507  659 FSSVVVELWHFRHLLDPFELKFqsIAHLIVTLLVLCIGLIPW--IDNWSHLFGTIFGLITSIIVYPYM 724
Cdd:pfam01694  82 LGALLVLGPRNRILLFGLIGAL--LALLLFILLNLVLGLLPGngVSNLAHLGGLLVGLLLGFILLRRP 147
 
Name Accession Description Interval E-value
Rhomboid pfam01694
Rhomboid family; This family contains integral membrane proteins that are related to ...
 580-724 3.71e-42

Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.


Pssm-ID: 426384  Cd Length: 147  Bit Score: 150.45  E-value: 3.71e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115534507  580 DNPNQIYRLFTSLFIHAGVIHLALSMAFQMYFMAYQENLIGSKRMAILYFASGISGNLASAIFVPY-YPTVGPSSAQCGV 658
Cdd:pfam01694   2 VQPGQLWRLITSMFLHAGWLHLLFNMLALLFFGGPLERILGSVRFLLLYLLSGIAGSLLSYLFSPLsTPSVGASGAIFGL 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 115534507  659 FSSVVVELWHFRHLLDPFELKFqsIAHLIVTLLVLCIGLIPW--IDNWSHLFGTIFGLITSIIVYPYM 724
Cdd:pfam01694  82 LGALLVLGPRNRILLFGLIGAL--LALLLFILLNLVLGLLPGngVSNLAHLGGLLVGLLLGFILLRRP 147
GlpG COG0705
Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein ...
 584-722 3.41e-25

Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440469 [Multi-domain]  Cd Length: 189  Bit Score: 103.40  E-value: 3.41e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115534507 584 QIYRLFTSLFIHAGVIHLALSMAFQMYFMAYQENLIGSKRMAILYFASGISGNLASAIF--VPYYPTVGPSSAQCGVFSS 661
Cdd:COG0705   42 ELWRLLTSMFLHGGFLHLLFNMLALWVFGPLLERRLGSKRFLLLYLLSGLGGGLLQLLFspGSGYPLVGASGAIFGLLGA 121

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 115534507 662 VVVelWHFRHLLDPFELKFQSIAHLIVTLLV-LCIGLIPW--IDNWSHLFGTIFGLITSIIVYP 722
Cdd:COG0705  122 LLV--LGPRRRVLLLFIPIPALLFLLVWLLLgLLFGLLGGggIAWEAHLGGLLAGLLLALLLRK 183
PTZ00101 PTZ00101
rhomboid-1 protease; Provisional
 584-671 2.73e-07

rhomboid-1 protease; Provisional


Pssm-ID: 185445  Cd Length: 278  Bit Score: 52.93  E-value: 2.73e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115534507 584 QIYRLFTSLFIHAGVIHLALSMAFQMYFMAYQENLIGSKRMAILYFASGISGNL--ASAIFVPYypTVGPSSAQCGVFSS 661
Cdd:PTZ00101 101 EIHRLILPIFLHANIFHTFFNVFFQLRMGFTLEKNYGIVKIIILYFLTGIYGNIlsSSVTYCPI--KVGASTSGMGLLGI 178

                         90
                 ....*....|....
gi 115534507 662 VVVEL---WH-FRH 671
Cdd:PTZ00101 179 VTSELillWHvIRH 192
 
Name Accession Description Interval E-value
Rhomboid pfam01694
Rhomboid family; This family contains integral membrane proteins that are related to ...
 580-724 3.71e-42

Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.


Pssm-ID: 426384  Cd Length: 147  Bit Score: 150.45  E-value: 3.71e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115534507  580 DNPNQIYRLFTSLFIHAGVIHLALSMAFQMYFMAYQENLIGSKRMAILYFASGISGNLASAIFVPY-YPTVGPSSAQCGV 658
Cdd:pfam01694   2 VQPGQLWRLITSMFLHAGWLHLLFNMLALLFFGGPLERILGSVRFLLLYLLSGIAGSLLSYLFSPLsTPSVGASGAIFGL 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 115534507  659 FSSVVVELWHFRHLLDPFELKFqsIAHLIVTLLVLCIGLIPW--IDNWSHLFGTIFGLITSIIVYPYM 724
Cdd:pfam01694  82 LGALLVLGPRNRILLFGLIGAL--LALLLFILLNLVLGLLPGngVSNLAHLGGLLVGLLLGFILLRRP 147
GlpG COG0705
Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein ...
 584-722 3.41e-25

Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440469 [Multi-domain]  Cd Length: 189  Bit Score: 103.40  E-value: 3.41e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115534507 584 QIYRLFTSLFIHAGVIHLALSMAFQMYFMAYQENLIGSKRMAILYFASGISGNLASAIF--VPYYPTVGPSSAQCGVFSS 661
Cdd:COG0705   42 ELWRLLTSMFLHGGFLHLLFNMLALWVFGPLLERRLGSKRFLLLYLLSGLGGGLLQLLFspGSGYPLVGASGAIFGLLGA 121

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 115534507 662 VVVelWHFRHLLDPFELKFQSIAHLIVTLLV-LCIGLIPW--IDNWSHLFGTIFGLITSIIVYP 722
Cdd:COG0705  122 LLV--LGPRRRVLLLFIPIPALLFLLVWLLLgLLFGLLGGggIAWEAHLGGLLAGLLLALLLRK 183
PTZ00101 PTZ00101
rhomboid-1 protease; Provisional
 584-671 2.73e-07

rhomboid-1 protease; Provisional


Pssm-ID: 185445  Cd Length: 278  Bit Score: 52.93  E-value: 2.73e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115534507 584 QIYRLFTSLFIHAGVIHLALSMAFQMYFMAYQENLIGSKRMAILYFASGISGNL--ASAIFVPYypTVGPSSAQCGVFSS 661
Cdd:PTZ00101 101 EIHRLILPIFLHANIFHTFFNVFFQLRMGFTLEKNYGIVKIIILYFLTGIYGNIlsSSVTYCPI--KVGASTSGMGLLGI 178

                         90
                 ....*....|....
gi 115534507 662 VVVEL---WH-FRH 671
Cdd:PTZ00101 179 VTSELillWHvIRH 192
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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