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Conserved domains on  [gi|193206828|ref|NP_502966|]
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Nematode cuticle collagen N-terminal domain-containing protein [Caenorhabditis elegans]

Protein Classification

cuticular collagen family protein( domain architecture ID 18387949)

cuticular collagen family protein is a structural macromolecule of the extracellular matrix containing triple helix domains that form tight interactions and stabilize supramolecular aggregates

Gene Ontology:  GO:0042302|GO:0005581
PubMed:  1916105|21421911

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Col_cuticle_N smart01088
Nematode cuticle collagen N-terminal domain; The function of this domain is unknown. It is ...
16-68 7.17e-20

Nematode cuticle collagen N-terminal domain; The function of this domain is unknown. It is found in the N-terminal region of nematode cuticle collagens. Cuticle is a tough elastic structure secreted by hypodermal cells and is primarily composed of collagen proteins.


:

Pssm-ID: 198156  Cd Length: 53  Bit Score: 81.74  E-value: 7.17e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 193206828    16 KIAFAGIAISTIATLTAILAIPMLYNYMQHVSSSLQTEVDFCQHRTDGLWDEY 68
Cdd:smart01088   1 LVAYVAVAVSTVAVLSALVTLPSIYNDIQSFQSELLDEMDEFKARADDAWNEM 53
gly_rich_SclB super family cl45768
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
163-338 1.02e-09

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


The actual alignment was detected with superfamily member NF038329:

Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 59.53  E-value: 1.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206828 163 GAVGPPGAPGQDGAPGNDGSSGAPGHPGQDAVDDSQAGPDSFCFDCPAGPPGPSGAPGQKGPSGAPGAPGQSGGSALPGP 242
Cdd:NF038329 120 GEPGPAGPAGPAGEQGPRGDRGETGPAGPAGPPGPQGERGEKGPAGPQGEAGPQGPAGKDGEAGAKGPAGEKGPQGPRGE 199
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206828 243 PGPAGSPGRSGQPGSNGNVGAPGAPGQVvdvpGAPGPAGPPGPPGPSGAPGHPGQAGSSLPGAPGPQGDAGAPGQPGAPG 322
Cdd:NF038329 200 TGPAGEQGPAGPAGPDGEAGPAGEDGPA----GPAGDGQQGPDGDPGPTGEDGPQGPDGPAGKDGPRGDRGEAGPDGPDG 275
                        170
                 ....*....|....*.
gi 193206828 323 QQGEPGEDGESGSEGA 338
Cdd:NF038329 276 KDGERGPVGPAGKDGQ 291
 
Name Accession Description Interval E-value
Col_cuticle_N smart01088
Nematode cuticle collagen N-terminal domain; The function of this domain is unknown. It is ...
16-68 7.17e-20

Nematode cuticle collagen N-terminal domain; The function of this domain is unknown. It is found in the N-terminal region of nematode cuticle collagens. Cuticle is a tough elastic structure secreted by hypodermal cells and is primarily composed of collagen proteins.


Pssm-ID: 198156  Cd Length: 53  Bit Score: 81.74  E-value: 7.17e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 193206828    16 KIAFAGIAISTIATLTAILAIPMLYNYMQHVSSSLQTEVDFCQHRTDGLWDEY 68
Cdd:smart01088   1 LVAYVAVAVSTVAVLSALVTLPSIYNDIQSFQSELLDEMDEFKARADDAWNEM 53
Col_cuticle_N pfam01484
Nematode cuticle collagen N-terminal domain; The function of this domain is unknown. It is ...
19-67 6.27e-16

Nematode cuticle collagen N-terminal domain; The function of this domain is unknown. It is found in the N-terminal region of nematode cuticle collagens, see pfam01391. Cuticle is a tough elastic structure secreted by hypodermal cells and is primarily composed of collagen proteins.


Pssm-ID: 460226  Cd Length: 50  Bit Score: 70.95  E-value: 6.27e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 193206828   19 FAGIAISTIATLTAILAIPMLYNYMQHVSSSLQTEVDFCQHRTDGLWDE 67
Cdd:pfam01484   1 YVAVAFSTVAILSSLITLPSIYNDIQELQSEVLDEMDEFKARSDDAWNE 49
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
163-338 1.02e-09

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 59.53  E-value: 1.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206828 163 GAVGPPGAPGQDGAPGNDGSSGAPGHPGQDAVDDSQAGPDSFCFDCPAGPPGPSGAPGQKGPSGAPGAPGQSGGSALPGP 242
Cdd:NF038329 120 GEPGPAGPAGPAGEQGPRGDRGETGPAGPAGPPGPQGERGEKGPAGPQGEAGPQGPAGKDGEAGAKGPAGEKGPQGPRGE 199
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206828 243 PGPAGSPGRSGQPGSNGNVGAPGAPGQVvdvpGAPGPAGPPGPPGPSGAPGHPGQAGSSLPGAPGPQGDAGAPGQPGAPG 322
Cdd:NF038329 200 TGPAGEQGPAGPAGPDGEAGPAGEDGPA----GPAGDGQQGPDGDPGPTGEDGPQGPDGPAGKDGPRGDRGEAGPDGPDG 275
                        170
                 ....*....|....*.
gi 193206828 323 QQGEPGEDGESGSEGA 338
Cdd:NF038329 276 KDGERGPVGPAGKDGQ 291
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
162-337 5.52e-09

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 57.22  E-value: 5.52e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206828 162 VGAVGPPGAPGQDGAPGNDGSSGAPGHPGQDAVDDSQAGPDSFCFDCPAGPPGPSGAPGQKGPSGAPGAPGQSGGSALPG 241
Cdd:NF038329 149 AGPPGPQGERGEKGPAGPQGEAGPQGPAGKDGEAGAKGPAGEKGPQGPRGETGPAGEQGPAGPAGPDGEAGPAGEDGPAG 228
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206828 242 PPGPAGSPGR-----SGQPGSNGNVGAPGAPGQVVDVPGAPGPAGPPGPPGPSGAPGHPGQAGSSLPGAPGPQGDAGAPG 316
Cdd:NF038329 229 PAGDGQQGPDgdpgpTGEDGPQGPDGPAGKDGPRGDRGEAGPDGPDGKDGERGPVGPAGKDGQNGKDGLPGKDGKDGQNG 308
                        170       180
                 ....*....|....*....|.
gi 193206828 317 QPGAPGQQGEPGEDGESGSEG 337
Cdd:NF038329 309 KDGLPGKDGKDGQPGKDGLPG 329
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
163-328 1.23e-05

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 46.82  E-value: 1.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206828 163 GAVGPPGAPGQDGAPGNDGSSGAPGHPGQDAVD--DSQAGPDSFCFDCPAGPPGPSGAPGQKGPSGAPGAPGQSGgsalp 240
Cdd:NF038329 189 GEKGPQGPRGETGPAGEQGPAGPAGPDGEAGPAgeDGPAGPAGDGQQGPDGDPGPTGEDGPQGPDGPAGKDGPRG----- 263
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206828 241 gPPGPAGSPGRSGQPGSNGNVGAPGAPGQvvdvpgapgpagpPGPPGPSGAPGHPGQAGSS-LPGAPGPQGDAGAPGQPG 319
Cdd:NF038329 264 -DRGEAGPDGPDGKDGERGPVGPAGKDGQ-------------NGKDGLPGKDGKDGQNGKDgLPGKDGKDGQPGKDGLPG 329

                 ....*....
gi 193206828 320 APGQQGEPG 328
Cdd:NF038329 330 KDGKDGQPG 338
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
141-336 2.01e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.44  E-value: 2.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206828 141 AATFSHASRAPASSGSCCSCGVGAVGPPGAPGQDGAPGNDGSSGAPGHPGQDAVDDSQAGPDSfcfdcPAGPPGPSGAPG 220
Cdd:PRK07764 588 VGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAP-----EHHPKHVAVPDA 662
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206828 221 QKGPSGAPGAPGQSGGSALPGPPGPAGSPGRSGQPGSngnVGAPGAPGQVVDVPGAPGPAGPPGPPGPSGAPGHPGQAGS 300
Cdd:PRK07764 663 SDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPA---QPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPV 739
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 193206828 301 SLPGAPGPQGDAGAPGQPGAPGQQGEPGEDGESGSE 336
Cdd:PRK07764 740 PLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPP 775
Collagen pfam01391
Collagen triple helix repeat (20 copies); Members of this family belong to the collagen ...
303-339 4.86e-04

Collagen triple helix repeat (20 copies); Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxy-proline. Collagens are post translationally modified by proline hydroxylase to form the hydroxy-proline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure. The family includes bacterial collagen-like triple-helix repeat proteins.


Pssm-ID: 460189 [Multi-domain]  Cd Length: 57  Bit Score: 37.86  E-value: 4.86e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 193206828  303 PGAPGPQGDAGAPGQPGAPGQQGEPGEDGESGSEGAC 339
Cdd:pfam01391  21 PGPPGPPGPPGEPGPPGPPGPPGPPGPPGAPGAPGPP 57
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
161-267 3.03e-03

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 39.12  E-value: 3.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206828 161 GVGAVGPPGAPGQDGAPGNDGSSGAPGHPGQDAvDDSQAGPDS-FCFDCPAGPPGPSGAPGQKGPSGAP---GAPGQSGG 236
Cdd:NF038329 231 GDGQQGPDGDPGPTGEDGPQGPDGPAGKDGPRG-DRGEAGPDGpDGKDGERGPVGPAGKDGQNGKDGLPgkdGKDGQNGK 309
                         90       100       110
                 ....*....|....*....|....*....|.
gi 193206828 237 SALPGPPGPAGSPGRSGQPGSNGNVGAPGAP 267
Cdd:NF038329 310 DGLPGKDGKDGQPGKDGLPGKDGKDGQPGKP 340
 
Name Accession Description Interval E-value
Col_cuticle_N smart01088
Nematode cuticle collagen N-terminal domain; The function of this domain is unknown. It is ...
16-68 7.17e-20

Nematode cuticle collagen N-terminal domain; The function of this domain is unknown. It is found in the N-terminal region of nematode cuticle collagens. Cuticle is a tough elastic structure secreted by hypodermal cells and is primarily composed of collagen proteins.


Pssm-ID: 198156  Cd Length: 53  Bit Score: 81.74  E-value: 7.17e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 193206828    16 KIAFAGIAISTIATLTAILAIPMLYNYMQHVSSSLQTEVDFCQHRTDGLWDEY 68
Cdd:smart01088   1 LVAYVAVAVSTVAVLSALVTLPSIYNDIQSFQSELLDEMDEFKARADDAWNEM 53
Col_cuticle_N pfam01484
Nematode cuticle collagen N-terminal domain; The function of this domain is unknown. It is ...
19-67 6.27e-16

Nematode cuticle collagen N-terminal domain; The function of this domain is unknown. It is found in the N-terminal region of nematode cuticle collagens, see pfam01391. Cuticle is a tough elastic structure secreted by hypodermal cells and is primarily composed of collagen proteins.


Pssm-ID: 460226  Cd Length: 50  Bit Score: 70.95  E-value: 6.27e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 193206828   19 FAGIAISTIATLTAILAIPMLYNYMQHVSSSLQTEVDFCQHRTDGLWDE 67
Cdd:pfam01484   1 YVAVAFSTVAILSSLITLPSIYNDIQELQSEVLDEMDEFKARSDDAWNE 49
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
163-338 1.02e-09

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 59.53  E-value: 1.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206828 163 GAVGPPGAPGQDGAPGNDGSSGAPGHPGQDAVDDSQAGPDSFCFDCPAGPPGPSGAPGQKGPSGAPGAPGQSGGSALPGP 242
Cdd:NF038329 120 GEPGPAGPAGPAGEQGPRGDRGETGPAGPAGPPGPQGERGEKGPAGPQGEAGPQGPAGKDGEAGAKGPAGEKGPQGPRGE 199
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206828 243 PGPAGSPGRSGQPGSNGNVGAPGAPGQVvdvpGAPGPAGPPGPPGPSGAPGHPGQAGSSLPGAPGPQGDAGAPGQPGAPG 322
Cdd:NF038329 200 TGPAGEQGPAGPAGPDGEAGPAGEDGPA----GPAGDGQQGPDGDPGPTGEDGPQGPDGPAGKDGPRGDRGEAGPDGPDG 275
                        170
                 ....*....|....*.
gi 193206828 323 QQGEPGEDGESGSEGA 338
Cdd:NF038329 276 KDGERGPVGPAGKDGQ 291
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
162-337 5.52e-09

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 57.22  E-value: 5.52e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206828 162 VGAVGPPGAPGQDGAPGNDGSSGAPGHPGQDAVDDSQAGPDSFCFDCPAGPPGPSGAPGQKGPSGAPGAPGQSGGSALPG 241
Cdd:NF038329 149 AGPPGPQGERGEKGPAGPQGEAGPQGPAGKDGEAGAKGPAGEKGPQGPRGETGPAGEQGPAGPAGPDGEAGPAGEDGPAG 228
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206828 242 PPGPAGSPGR-----SGQPGSNGNVGAPGAPGQVVDVPGAPGPAGPPGPPGPSGAPGHPGQAGSSLPGAPGPQGDAGAPG 316
Cdd:NF038329 229 PAGDGQQGPDgdpgpTGEDGPQGPDGPAGKDGPRGDRGEAGPDGPDGKDGERGPVGPAGKDGQNGKDGLPGKDGKDGQNG 308
                        170       180
                 ....*....|....*....|.
gi 193206828 317 QPGAPGQQGEPGEDGESGSEG 337
Cdd:NF038329 309 KDGLPGKDGKDGQPGKDGLPG 329
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
163-328 1.23e-05

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 46.82  E-value: 1.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206828 163 GAVGPPGAPGQDGAPGNDGSSGAPGHPGQDAVD--DSQAGPDSFCFDCPAGPPGPSGAPGQKGPSGAPGAPGQSGgsalp 240
Cdd:NF038329 189 GEKGPQGPRGETGPAGEQGPAGPAGPDGEAGPAgeDGPAGPAGDGQQGPDGDPGPTGEDGPQGPDGPAGKDGPRG----- 263
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206828 241 gPPGPAGSPGRSGQPGSNGNVGAPGAPGQvvdvpgapgpagpPGPPGPSGAPGHPGQAGSS-LPGAPGPQGDAGAPGQPG 319
Cdd:NF038329 264 -DRGEAGPDGPDGKDGERGPVGPAGKDGQ-------------NGKDGLPGKDGKDGQNGKDgLPGKDGKDGQPGKDGLPG 329

                 ....*....
gi 193206828 320 APGQQGEPG 328
Cdd:NF038329 330 KDGKDGQPG 338
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
141-336 2.01e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.44  E-value: 2.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206828 141 AATFSHASRAPASSGSCCSCGVGAVGPPGAPGQDGAPGNDGSSGAPGHPGQDAVDDSQAGPDSfcfdcPAGPPGPSGAPG 220
Cdd:PRK07764 588 VGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAP-----EHHPKHVAVPDA 662
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206828 221 QKGPSGAPGAPGQSGGSALPGPPGPAGSPGRSGQPGSngnVGAPGAPGQVVDVPGAPGPAGPPGPPGPSGAPGHPGQAGS 300
Cdd:PRK07764 663 SDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPA---QPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPV 739
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 193206828 301 SLPGAPGPQGDAGAPGQPGAPGQQGEPGEDGESGSE 336
Cdd:PRK07764 740 PLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPP 775
Collagen pfam01391
Collagen triple helix repeat (20 copies); Members of this family belong to the collagen ...
303-339 4.86e-04

Collagen triple helix repeat (20 copies); Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxy-proline. Collagens are post translationally modified by proline hydroxylase to form the hydroxy-proline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure. The family includes bacterial collagen-like triple-helix repeat proteins.


Pssm-ID: 460189 [Multi-domain]  Cd Length: 57  Bit Score: 37.86  E-value: 4.86e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 193206828  303 PGAPGPQGDAGAPGQPGAPGQQGEPGEDGESGSEGAC 339
Cdd:pfam01391  21 PGPPGPPGPPGEPGPPGPPGPPGPPGPPGAPGAPGPP 57
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
126-330 1.18e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.74  E-value: 1.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206828 126 TAAPVAQAQVPASSFAATFSHASRAPASSGsccscGVGAVGPPGAPGQDGAPGNDGSSGAPGHPGQDAVDDSQAGPDSFC 205
Cdd:PRK07764 590 PAPGAAGGEGPPAPASSGPPEEAARPAAPA-----APAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASD 664
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206828 206 FDCPAGPPGPSGAPGQKGPSGAPGAPGQSGGSALPGPPGPAGSPGRSGQPGSNGN----VGAPGAPGQVVDVPGAPGPAG 281
Cdd:PRK07764 665 GGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAqppqAAQGASAPSPAADDPVPLPPE 744
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 193206828 282 PPGPPGPSGAPGHpgqagsslPGAPGPQGDAGAPGQPGAPGQQGEPGED 330
Cdd:PRK07764 745 PDDPPDPAGAPAQ--------PPPPPAPAPAAAPAAAPPPSPPSEEEEM 785
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
161-267 3.03e-03

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 39.12  E-value: 3.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206828 161 GVGAVGPPGAPGQDGAPGNDGSSGAPGHPGQDAvDDSQAGPDS-FCFDCPAGPPGPSGAPGQKGPSGAP---GAPGQSGG 236
Cdd:NF038329 231 GDGQQGPDGDPGPTGEDGPQGPDGPAGKDGPRG-DRGEAGPDGpDGKDGERGPVGPAGKDGQNGKDGLPgkdGKDGQNGK 309
                         90       100       110
                 ....*....|....*....|....*....|.
gi 193206828 237 SALPGPPGPAGSPGRSGQPGSNGNVGAPGAP 267
Cdd:NF038329 310 DGLPGKDGKDGQPGKDGLPGKDGKDGQPGKP 340
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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