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Conserved domains on  [gi|808356278|ref|NP_502840|]
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Serpentine Receptor, class J [Caenorhabditis elegans]

Protein Classification

class J serpentine receptor( domain architecture ID 10563403)

class J serpentine receptor (Srj) belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
1-308 3.66e-133

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 370974  Cd Length: 310  Bit Score: 381.59  E-value: 3.66e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356278    1 MLEDWIYQYLPATFCVLAFLVNPFFIYLIFTEDPTKFGNYRYLLLSFSIFNMVYSILNVLVPIDIHTYSYCMFLIIKRGW 80
Cdd:pfam10319   1 MYINWAHYYIPKIFGVLSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFVSDGP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356278   81 FVERSDLHFHLLLIRCSMLGGSYGILLIHFIYRYLVIHNSSLTKKYFY-IYMLGSFITFAFYYFYWYATCYFLGQAGPEM 159
Cdd:pfam10319  81 FFEYSELGQHALSARCSFISASYAVLLIHFIYRYLVLFNPQLTRHYFRpWGILISILFFLFHGSVWTAICYFLLRANDEI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356278  160 KQYVSEDFAIVYGENSTNFNMVGVIYHKGVAYITKvRSWLTVFLCSFLSVASIIAFVFFARLVMKKLNQAST--SIKTST 237
Cdd:pfam10319 161 RDYIREDFRETYGVDSMDINMLGALYWEASDETVF-RSWLGILLLTVISVYSIILYIVLGYKIMRKLNKMSVtmSKKTKR 239
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 808356278  238 FQFELLRALIVQTLIPIVISFSPCLLCWYSPIFGIQFARGFNYFEVSALSVFSFVDPVAIILCLPIFRVRV 308
Cdd:pfam10319 240 LQKQLLKALIVQTIIPICISFSPCVLAWYSPIFGIDLGRWNNYLEVIALSAFPFIDPLAIILCLPVYRNRI 310
 
Name Accession Description Interval E-value
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
1-308 3.66e-133

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 381.59  E-value: 3.66e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356278    1 MLEDWIYQYLPATFCVLAFLVNPFFIYLIFTEDPTKFGNYRYLLLSFSIFNMVYSILNVLVPIDIHTYSYCMFLIIKRGW 80
Cdd:pfam10319   1 MYINWAHYYIPKIFGVLSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFVSDGP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356278   81 FVERSDLHFHLLLIRCSMLGGSYGILLIHFIYRYLVIHNSSLTKKYFY-IYMLGSFITFAFYYFYWYATCYFLGQAGPEM 159
Cdd:pfam10319  81 FFEYSELGQHALSARCSFISASYAVLLIHFIYRYLVLFNPQLTRHYFRpWGILISILFFLFHGSVWTAICYFLLRANDEI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356278  160 KQYVSEDFAIVYGENSTNFNMVGVIYHKGVAYITKvRSWLTVFLCSFLSVASIIAFVFFARLVMKKLNQAST--SIKTST 237
Cdd:pfam10319 161 RDYIREDFRETYGVDSMDINMLGALYWEASDETVF-RSWLGILLLTVISVYSIILYIVLGYKIMRKLNKMSVtmSKKTKR 239
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 808356278  238 FQFELLRALIVQTLIPIVISFSPCLLCWYSPIFGIQFARGFNYFEVSALSVFSFVDPVAIILCLPIFRVRV 308
Cdd:pfam10319 240 LQKQLLKALIVQTIIPICISFSPCVLAWYSPIFGIDLGRWNNYLEVIALSAFPFIDPLAIILCLPVYRNRI 310
 
Name Accession Description Interval E-value
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
1-308 3.66e-133

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 381.59  E-value: 3.66e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356278    1 MLEDWIYQYLPATFCVLAFLVNPFFIYLIFTEDPTKFGNYRYLLLSFSIFNMVYSILNVLVPIDIHTYSYCMFLIIKRGW 80
Cdd:pfam10319   1 MYINWAHYYIPKIFGVLSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFVSDGP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356278   81 FVERSDLHFHLLLIRCSMLGGSYGILLIHFIYRYLVIHNSSLTKKYFY-IYMLGSFITFAFYYFYWYATCYFLGQAGPEM 159
Cdd:pfam10319  81 FFEYSELGQHALSARCSFISASYAVLLIHFIYRYLVLFNPQLTRHYFRpWGILISILFFLFHGSVWTAICYFLLRANDEI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356278  160 KQYVSEDFAIVYGENSTNFNMVGVIYHKGVAYITKvRSWLTVFLCSFLSVASIIAFVFFARLVMKKLNQAST--SIKTST 237
Cdd:pfam10319 161 RDYIREDFRETYGVDSMDINMLGALYWEASDETVF-RSWLGILLLTVISVYSIILYIVLGYKIMRKLNKMSVtmSKKTKR 239
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 808356278  238 FQFELLRALIVQTLIPIVISFSPCLLCWYSPIFGIQFARGFNYFEVSALSVFSFVDPVAIILCLPIFRVRV 308
Cdd:pfam10319 240 LQKQLLKALIVQTIIPICISFSPCVLAWYSPIFGIDLGRWNNYLEVIALSAFPFIDPLAIILCLPVYRNRI 310
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
15-309 4.61e-44

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 153.38  E-value: 4.61e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356278   15 CVLAFLVNPFFIYLIFTEDPTKFGNYRYLLLSFSIFNMVYSILNVLVPIDIHTYSYCMFLIIKRGWFVERSDLHFHLLLI 94
Cdd:pfam10326   9 FFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKSVGQILLAL 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356278   95 RCSMLGGSYGILLIHFIYRYLVIHNSSLTKKYFYIYMLGSFITFAFYYFYWYATCYFLGQAGPEMKQYVSEDFAIVYGEN 174
Cdd:pfam10326  89 YCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREELLENYNLD 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356278  175 STNFNMVGVIYHKGVAYITKV---RSWLTVFLCSFLSVASIIAFVFFA---RLVMKKLnQASTSIKTSTFQFELLRALIV 248
Cdd:pfam10326 169 IDEVAYVGPVYYPTDENGSKVirwRSLIGLLIMTFIIGISFSIIIYCGikmYFKMKKL-KSLGSEKTRKLQKQLFKALVI 247
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 808356278  249 QTLIPIVISFSPCLLCWYSPIFGIQFARGFNYFeVSALSVFSFVDPVAIILCLPIFRVRVL 309
Cdd:pfam10326 248 QTLIPTILMYIPVGILFLLPLFNIEIGFLSGII-TATIALYPAIDPLPAMFIIKEYRNAIK 307
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
7-310 2.36e-08

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 54.48  E-value: 2.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356278    7 YQYLPATFCVLAFLVNPFFIYLIFTEDPTKFGNYRYLLLSFSIFNMVYSILNVLVPIDIHTYSYCMFLIIkRG---WFVE 83
Cdd:pfam10317   1 FSIYYPIFFILGLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQRIIPNGVSMALIS-YGpckYFGP 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356278   84 RSDLHFHLLLIRCSMLGGSygILLIHFIYRYLVIHNSSLT-KKYFYIYMLGSFITFAFyyfywyATCYFLGQAGPEMKQY 162
Cdd:pfam10317  80 WFCYSGYSLLQHFLLHSGW--SLLLTFYYRYYILKHVDPKrKKLILLIIIHYIPSLSQ------LIVIFLSPTDFLPVEA 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356278  163 VSEDFAIVYGENSTNFNmvgviyhkGVAYITKVRSWLTVFLCSFLSVASIIAFVFFARLVMKKLN--QASTSIKTSTFQF 240
Cdd:pfam10317 152 LTKELHPNYNLTDYTVT--------GFSDLQSFPALINTLIMTIPVFPIPIIILILRRKILKLLNsnSVNMSPTTKAQHR 223
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356278  241 ELLRALIVQTLIPIVISFSPCLLCWYSPIFGIQFARgFNYFEVSALSVFSFVDPVAIILCLPIFRVRVLK 310
Cdd:pfam10317 224 QLIKGLTIQALLPLFSYIPGVTLYLLSQLTGTEFLI-LEYFIFVLPALPPLLDPLITIYFVTPYRRAILR 292
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
16-299 1.61e-05

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 46.00  E-value: 1.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356278   16 VLAFLVNPFFIYLIFTEDPTKFGNYRYLLLSFSIFNMVYSI-LNVLVPIDIHTYSYCMFLIIKRGWFVERSDLHFHLLLI 94
Cdd:pfam10318  15 VISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLsLSFLTIPYIFLPALAGYPLGLLSYLGVPTPIQFYIGVT 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356278   95 RCSMLGGSYGILlihFIYRY--LVIHNSSLTKKYFYIYMLGSFITFAFYYFywyATCYFLGQAGPEMKQYVSEDFAIVYG 172
Cdd:pfam10318  95 SLALVGVSIILL---FENRYsiLFTNKKRITWKKTRVLYLIFNYIIALLFL---IPIYLNIPDQEAAKLKVLKKLPCLPP 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356278  173 ENSTNFNMVgviyhkgVAYITKVRSWLTVFLCSFLSVASIIAFVFFARLVMKKLNQASTSIKTSTFQFELLRALIVQTLI 252
Cdd:pfam10318 169 EFFDNPPVF-------VLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVKSSLSKKTRKLQKKFFIALIIQVSI 241
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 808356278  253 PIVISFSPCLLCWYSPIFGiQFARGFNYFEVSALSVFSFVDPVAIIL 299
Cdd:pfam10318 242 PLIVILIPLIYILFSIIFG-YYNQALNNLLFIIISLHGLLSTIAMLL 287
7TM_GPCR_Sri pfam10327
Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis ...
16-263 2.99e-04

Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sri is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 313539  Cd Length: 303  Bit Score: 42.15  E-value: 2.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356278   16 VLAFLVNPFFIYLIFTEDPtKFGNYRYLLLSFSIFNMVYSI-LNVLVPIdihTYSYCMFLIIKRGWFVERSDLHFHLLL- 93
Cdd:pfam10327  20 TISLILNLLGIYLIIFKSG-KIDNFRYYLLYFQISCTLTDIhLTFLMQP---IPLFPIIAGYCNGFLATVFGISSHYLMt 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356278   94 IRCSMLGGSYGILLIHFIYRYLVIHN---SSLTKKYFYIYMLGSFITFAFYYFYWYatcYFLGQAGPEMKQYVSEDFAIV 170
Cdd:pfam10327  96 IFVFLLSFQLESLLLCFVRKHQAIAKilsKHVIPKWLYIFLYILCHIFPFLTAFLF---YQSGLSREEQLEYVKENYPEY 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356278  171 YGENSTNFNMvgVIYHKgvayitkvRSWLTVFLCSFLSVASIIAFVFFARLV--MKKLNQASTSIKTSTFQF--ELLRAL 246
Cdd:pfam10327 173 LSQFSSLPNF--AIYDY--------NPWLIVFGILAIFGGSLSFLILVYLTVdmFRMLKRLRKKISAQTYQKhrAALRSL 242
                         250
                  ....*....|....*..
gi 808356278  247 IVQTLIPIVISFSPCLL 263
Cdd:pfam10327 243 IAQFATSPVCILPPFAF 259
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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