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Conserved domains on  [gi|17540572|ref|NP_502699|]
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PAN domain protein [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAN_AP_HGF cd01099
Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen ...
 125-203 6.61e-21

Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


:

Pssm-ID: 238532  Cd Length: 80  Bit Score: 87.14  E-value: 6.61e-21
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17540572 125 RSFSFERARNTQLEGFVKKSVTVENREHCLSACLKEKEFVCKSVNFHYDTSLCELSVEDKRSKPTHVRMSEKIDYYDNN 203
Cdd:cd01099   2 NDFKFVLVLNKILVSEVKTEITVASLEECLRKCLEETEFTCRSFNYNYKSKECILSDEDRMSSGVKLLYDSNVDYYENK 80
PAN_AP_HGF cd01099
Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen ...
 217-292 4.63e-14

Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


:

Pssm-ID: 238532  Cd Length: 80  Bit Score: 67.88  E-value: 4.63e-14
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17540572 217 NLVFVKTTNFEIRYYDHTQSVEAQESYCLQKCLDSLNTFCRSVEFNPKEKNCIVSDEDTFSRADQQGQVVGKDYYE 292
Cdd:cd01099   3 DFKFVLVLNKILVSEVKTEITVASLEECLRKCLEETEFTCRSFNYNYKSKECILSDEDRMSSGVKLLYDSNVDYYE 78
ZP super family cl42957
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
 392-634 8.72e-10

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


The actual alignment was detected with superfamily member smart00241:

Pssm-ID: 214579  Cd Length: 252  Bit Score: 60.09  E-value: 8.72e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540572    392 CTNEGIRFIVNTKEPYTGAIYAAERF---STCSQVVENAKQ--ISITFPPptvsSDCGT-VIRDGK---MEALVVVSldg 462
Cdd:smart00241   2 CGEDQMVVSVSTDLLFPGGINVKGLTlgdPSCRPQFTDATSafVSFEVPL----NGCGTrRQVNPDgivYSNTLVVS--- 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540572    463 VLPHQVTTEWDRF-YRVSCdvsmdkmvkegsvvvttIYEASSQNTTVLDVATPPPVSAE----------LQILN-QLEEP 530
Cdd:smart00241  75 PFHPGFITRDDRAaYHFQC-----------------FYPENEKVSLNLDVSTIPPTELSsvsegpltcsYRLYKdDSFGS 137

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540572    531 LHKAS---IGDPLLLVITSEQAGPHN--MMVTECTATRVGGFGDTVPFTLIENGCP--RYPALVGPVEQDFDkNRLKSDL 603
Cdd:smart00241 138 PYQSAdyvLGDPVYHEWECDGADDPPlgLLVDNCYATPGPDPSSGPKYFIIDNGCPvdGYLDSTIPYNSNPL-HRARFSV 216

                          250       260       270
                   ....*....|....*....|....*....|...
gi 17540572    604 RAFRLDGSYDVQIVCSIMFC--AGPNGCPVSNC 634
Cdd:smart00241 217 KVFKFADRSLVYFHCQIRLCdkDDGSSCDGPAC 249
PAN_1 pfam00024
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
 310-382 3.84e-09

PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.


:

Pssm-ID: 459635  Cd Length: 76  Bit Score: 53.71  E-value: 3.84e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17540572   310 AFERFIGSSIEGEVVASAQGVTISDCISLCFQNLNCKSINYDRTASSCFIYAVGRQDAN--IKANPSMDYYEFNC 382
Cdd:pfam00024   2 DFERVPGSSLSGVDVSTVTVSSAEECAQRCTNEPRCRSFTYNPKSKKCHLKSSSSGSLPrlKRSDNKVDYYEKSC 76
PAN_1 pfam00024
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
 28-112 1.53e-05

PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.


:

Pssm-ID: 459635  Cd Length: 76  Bit Score: 43.70  E-value: 1.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540572    28 AFVRIPRARLDGTPVVISTAGHDLTCAQYCRNNIEpttgaqrvCASFNFD-GRETCYFFDDAATPAGTSQLTANpsaNNF 106
Cdd:pfam00024   2 DFERVPGSSLSGVDVSTVTVSSAEECAQRCTNEPR--------CRSFTYNpKSKKCHLKSSSSGSLPRLKRSDN---KVD 70


                  ....*.
gi 17540572   107 YYEKTC 112
Cdd:pfam00024  71 YYEKSC 76
 
Name Accession Description Interval E-value
PAN_AP_HGF cd01099
Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen ...
 125-203 6.61e-21

Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


Pssm-ID: 238532  Cd Length: 80  Bit Score: 87.14  E-value: 6.61e-21
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17540572 125 RSFSFERARNTQLEGFVKKSVTVENREHCLSACLKEKEFVCKSVNFHYDTSLCELSVEDKRSKPTHVRMSEKIDYYDNN 203
Cdd:cd01099   2 NDFKFVLVLNKILVSEVKTEITVASLEECLRKCLEETEFTCRSFNYNYKSKECILSDEDRMSSGVKLLYDSNVDYYENK 80
PAN_1 pfam00024
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
 128-204 8.80e-15

PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.


Pssm-ID: 459635  Cd Length: 76  Bit Score: 69.89  E-value: 8.80e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17540572   128 SFERARNTQLEGFVKKSVTVENREHCLSACLKEKEfvCKSVNFHYDTSLCELSVEDKRSKPTHVRMSEKIDYYDNNC 204
Cdd:pfam00024   2 DFERVPGSSLSGVDVSTVTVSSAEECAQRCTNEPR--CRSFTYNPKSKKCHLKSSSSGSLPRLKRSDNKVDYYEKSC 76
PAN_AP_HGF cd01099
Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen ...
 217-292 4.63e-14

Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


Pssm-ID: 238532  Cd Length: 80  Bit Score: 67.88  E-value: 4.63e-14
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17540572 217 NLVFVKTTNFEIRYYDHTQSVEAQESYCLQKCLDSLNTFCRSVEFNPKEKNCIVSDEDTFSRADQQGQVVGKDYYE 292
Cdd:cd01099   3 DFKFVLVLNKILVSEVKTEITVASLEECLRKCLEETEFTCRSFNYNYKSKECILSDEDRMSSGVKLLYDSNVDYYE 78
PAN_AP smart00473
divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans ...
 125-203 1.04e-11

divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans hypothetical ORFs and the extracellular portion of plant receptor-like protein kinases. Predicted to possess protein- and/or carbohydrate-binding functions.


Pssm-ID: 214680  Cd Length: 78  Bit Score: 61.06  E-value: 1.04e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17540572    125 RSFSFERARNTQLEGFVKKSVTVENREHCLSACLKEKeFVCKSVNFHYDTSLCELSVEDKRSKPTHVRmSEKIDYYDNN 203
Cdd:smart00473   2 SDDCFVRLPNTKLPGFSRIVISVASLEECASKCLNSN-CSCRSFTYNNGTKGCLLWSESSLGDARLFP-SGGVDLYEKI 78
PAN_AP smart00473
divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans ...
 220-294 5.85e-10

divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans hypothetical ORFs and the extracellular portion of plant receptor-like protein kinases. Predicted to possess protein- and/or carbohydrate-binding functions.


Pssm-ID: 214680  Cd Length: 78  Bit Score: 56.05  E-value: 5.85e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17540572    220 FVKTTNFEIRYYDHTQSVEAQESYCLQKCLDSlNTFCRSVEFNPKEKNCIVSDEDTFSRAdQQGQVVGKDYYEPI 294
Cdd:smart00473   6 FVRLPNTKLPGFSRIVISVASLEECASKCLNS-NCSCRSFTYNNGTKGCLLWSESSLGDA-RLFPSGGVDLYEKI 78
ZP smart00241
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
 392-634 8.72e-10

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


Pssm-ID: 214579  Cd Length: 252  Bit Score: 60.09  E-value: 8.72e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540572    392 CTNEGIRFIVNTKEPYTGAIYAAERF---STCSQVVENAKQ--ISITFPPptvsSDCGT-VIRDGK---MEALVVVSldg 462
Cdd:smart00241   2 CGEDQMVVSVSTDLLFPGGINVKGLTlgdPSCRPQFTDATSafVSFEVPL----NGCGTrRQVNPDgivYSNTLVVS--- 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540572    463 VLPHQVTTEWDRF-YRVSCdvsmdkmvkegsvvvttIYEASSQNTTVLDVATPPPVSAE----------LQILN-QLEEP 530
Cdd:smart00241  75 PFHPGFITRDDRAaYHFQC-----------------FYPENEKVSLNLDVSTIPPTELSsvsegpltcsYRLYKdDSFGS 137

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540572    531 LHKAS---IGDPLLLVITSEQAGPHN--MMVTECTATRVGGFGDTVPFTLIENGCP--RYPALVGPVEQDFDkNRLKSDL 603
Cdd:smart00241 138 PYQSAdyvLGDPVYHEWECDGADDPPlgLLVDNCYATPGPDPSSGPKYFIIDNGCPvdGYLDSTIPYNSNPL-HRARFSV 216

                          250       260       270
                   ....*....|....*....|....*....|...
gi 17540572    604 RAFRLDGSYDVQIVCSIMFC--AGPNGCPVSNC 634
Cdd:smart00241 217 KVFKFADRSLVYFHCQIRLCdkDDGSSCDGPAC 249
PAN_1 pfam00024
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
 310-382 3.84e-09

PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.


Pssm-ID: 459635  Cd Length: 76  Bit Score: 53.71  E-value: 3.84e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17540572   310 AFERFIGSSIEGEVVASAQGVTISDCISLCFQNLNCKSINYDRTASSCFIYAVGRQDAN--IKANPSMDYYEFNC 382
Cdd:pfam00024   2 DFERVPGSSLSGVDVSTVTVSSAEECAQRCTNEPRCRSFTYNPKSKKCHLKSSSSGSLPrlKRSDNKVDYYEKSC 76
PAN_1 pfam00024
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
 220-295 5.40e-09

PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.


Pssm-ID: 459635  Cd Length: 76  Bit Score: 53.33  E-value: 5.40e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17540572   220 FVKTTNFEIRYYDHTQSVEAQESYCLQKCLDslNTFCRSVEFNPKEKNCIVSDEDTFSRADQQGQVVGKDYYEPIC 295
Cdd:pfam00024   3 FERVPGSSLSGVDVSTVTVSSAEECAQRCTN--EPRCRSFTYNPKSKKCHLKSSSSGSLPRLKRSDNKVDYYEKSC 76
Zona_pellucida pfam00100
Zona pellucida-like domain;
392-634 7.09e-09

Zona pellucida-like domain;


Pssm-ID: 459673 [Multi-domain]  Cd Length: 254  Bit Score: 57.23  E-value: 7.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540572   392 CTNEGIRFIVNTKEPYTGAIYAA-----ERFSTCSQVVENAKQISITFPPPtvSSDCGTVIR--DGKM--EALVVVSLDG 462
Cdd:pfam00100   1 CTPDTMTVSISKCLLVPSGLLSSlsllgGLDPSCKPVSNTNGSPAVLFEFP--LTGCGTTVQvnGTHIiySNTLYSSTDL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540572   463 VLPHQVTTEWDRFYrVSCDVSMDKMVKEGSVVVTTIYEASSQNTTVLDVatpppvsaELQILN------QLEEPLHKASI 536
Cdd:pfam00100  79 RSGIIRRTITRRLP-FSCSYPRSSLVSLLVVAPPSPVPITVSGSGVFLV--------SMDLYYdssytsPYSPYPVTVLL 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540572   537 GDPLLLVITSEQAGPHN--MMVTECTATRVGGFGDTVPFTLIENGCPRYPALVGPVEQDFDKNRLKS--DLRAFRLDGSY 612
Cdd:pfam00100 150 GDPLYVEVSLLSRTDPNlvLVLDNCWATPSPNPTSSPQYQLIVNGCPNDGDSTYPVSSLSNGPSHYVrfSFKAFRFVGSS 229

                         250       260
                  ....*....|....*....|....
gi 17540572   613 D--VQIVCSIMFCAGPNGCPVSNC 634
Cdd:pfam00100 230 IsqVYLHCSVSVCSSDSNSCGKSC 253
PAN_AP smart00473
divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans ...
 310-379 1.16e-08

divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans hypothetical ORFs and the extracellular portion of plant receptor-like protein kinases. Predicted to possess protein- and/or carbohydrate-binding functions.


Pssm-ID: 214680  Cd Length: 78  Bit Score: 52.58  E-value: 1.16e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17540572    310 AFERFIGSSIEGEVVASAQGVTISDCISLCFQ-NLNCKSINYDRTASSCFIYAVGR-QDANIKANPSMDYYE 379
Cdd:smart00473   5 CFVRLPNTKLPGFSRIVISVASLEECASKCLNsNCSCRSFTYNNGTKGCLLWSESSlGDARLFPSGGVDLYE 76
PAN_1 pfam00024
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
 28-112 1.53e-05

PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.


Pssm-ID: 459635  Cd Length: 76  Bit Score: 43.70  E-value: 1.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540572    28 AFVRIPRARLDGTPVVISTAGHDLTCAQYCRNNIEpttgaqrvCASFNFD-GRETCYFFDDAATPAGTSQLTANpsaNNF 106
Cdd:pfam00024   2 DFERVPGSSLSGVDVSTVTVSSAEECAQRCTNEPR--------CRSFTYNpKSKKCHLKSSSSGSLPRLKRSDN---KVD 70


                  ....*.
gi 17540572   107 YYEKTC 112
Cdd:pfam00024  71 YYEKSC 76
PAN_AP smart00473
divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans ...
 25-111 4.42e-05

divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans hypothetical ORFs and the extracellular portion of plant receptor-like protein kinases. Predicted to possess protein- and/or carbohydrate-binding functions.


Pssm-ID: 214680  Cd Length: 78  Bit Score: 42.18  E-value: 4.42e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540572     25 ETTAFVRIPRARLDGTPVVISTAGHDLTCAQYCRNNiepttgaQRVCASFNFD-GRETCYFFDDaatpAGTSQLTANPSA 103
Cdd:smart00473   2 SDDCFVRLPNTKLPGFSRIVISVASLEECASKCLNS-------NCSCRSFTYNnGTKGCLLWSE----SSLGDARLFPSG 70


                   ....*...
gi 17540572    104 NNFYYEKT 111
Cdd:smart00473  71 GVDLYEKI 78
PAN_AP_HGF cd01099
Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen ...
 310-379 1.44e-03

Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


Pssm-ID: 238532  Cd Length: 80  Bit Score: 38.22  E-value: 1.44e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17540572 310 AFERFIGSSIEGEVVASAQGVTISDCISLCFQNLN--CKSINYDRTASSCFIYAVGRQDANIKA--NPSMDYYE 379
Cdd:cd01099   5 KFVLVLNKILVSEVKTEITVASLEECLRKCLEETEftCRSFNYNYKSKECILSDEDRMSSGVKLlyDSNVDYYE 78
 
Name Accession Description Interval E-value
PAN_AP_HGF cd01099
Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen ...
 125-203 6.61e-21

Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


Pssm-ID: 238532  Cd Length: 80  Bit Score: 87.14  E-value: 6.61e-21
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17540572 125 RSFSFERARNTQLEGFVKKSVTVENREHCLSACLKEKEFVCKSVNFHYDTSLCELSVEDKRSKPTHVRMSEKIDYYDNN 203
Cdd:cd01099   2 NDFKFVLVLNKILVSEVKTEITVASLEECLRKCLEETEFTCRSFNYNYKSKECILSDEDRMSSGVKLLYDSNVDYYENK 80
PAN_1 pfam00024
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
 128-204 8.80e-15

PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.


Pssm-ID: 459635  Cd Length: 76  Bit Score: 69.89  E-value: 8.80e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17540572   128 SFERARNTQLEGFVKKSVTVENREHCLSACLKEKEfvCKSVNFHYDTSLCELSVEDKRSKPTHVRMSEKIDYYDNNC 204
Cdd:pfam00024   2 DFERVPGSSLSGVDVSTVTVSSAEECAQRCTNEPR--CRSFTYNPKSKKCHLKSSSSGSLPRLKRSDNKVDYYEKSC 76
PAN_AP_HGF cd01099
Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen ...
 217-292 4.63e-14

Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


Pssm-ID: 238532  Cd Length: 80  Bit Score: 67.88  E-value: 4.63e-14
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17540572 217 NLVFVKTTNFEIRYYDHTQSVEAQESYCLQKCLDSLNTFCRSVEFNPKEKNCIVSDEDTFSRADQQGQVVGKDYYE 292
Cdd:cd01099   3 DFKFVLVLNKILVSEVKTEITVASLEECLRKCLEETEFTCRSFNYNYKSKECILSDEDRMSSGVKLLYDSNVDYYE 78
PAN_AP smart00473
divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans ...
 125-203 1.04e-11

divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans hypothetical ORFs and the extracellular portion of plant receptor-like protein kinases. Predicted to possess protein- and/or carbohydrate-binding functions.


Pssm-ID: 214680  Cd Length: 78  Bit Score: 61.06  E-value: 1.04e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17540572    125 RSFSFERARNTQLEGFVKKSVTVENREHCLSACLKEKeFVCKSVNFHYDTSLCELSVEDKRSKPTHVRmSEKIDYYDNN 203
Cdd:smart00473   2 SDDCFVRLPNTKLPGFSRIVISVASLEECASKCLNSN-CSCRSFTYNNGTKGCLLWSESSLGDARLFP-SGGVDLYEKI 78
PAN_AP smart00473
divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans ...
 220-294 5.85e-10

divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans hypothetical ORFs and the extracellular portion of plant receptor-like protein kinases. Predicted to possess protein- and/or carbohydrate-binding functions.


Pssm-ID: 214680  Cd Length: 78  Bit Score: 56.05  E-value: 5.85e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17540572    220 FVKTTNFEIRYYDHTQSVEAQESYCLQKCLDSlNTFCRSVEFNPKEKNCIVSDEDTFSRAdQQGQVVGKDYYEPI 294
Cdd:smart00473   6 FVRLPNTKLPGFSRIVISVASLEECASKCLNS-NCSCRSFTYNNGTKGCLLWSESSLGDA-RLFPSGGVDLYEKI 78
ZP smart00241
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
 392-634 8.72e-10

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


Pssm-ID: 214579  Cd Length: 252  Bit Score: 60.09  E-value: 8.72e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540572    392 CTNEGIRFIVNTKEPYTGAIYAAERF---STCSQVVENAKQ--ISITFPPptvsSDCGT-VIRDGK---MEALVVVSldg 462
Cdd:smart00241   2 CGEDQMVVSVSTDLLFPGGINVKGLTlgdPSCRPQFTDATSafVSFEVPL----NGCGTrRQVNPDgivYSNTLVVS--- 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540572    463 VLPHQVTTEWDRF-YRVSCdvsmdkmvkegsvvvttIYEASSQNTTVLDVATPPPVSAE----------LQILN-QLEEP 530
Cdd:smart00241  75 PFHPGFITRDDRAaYHFQC-----------------FYPENEKVSLNLDVSTIPPTELSsvsegpltcsYRLYKdDSFGS 137

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540572    531 LHKAS---IGDPLLLVITSEQAGPHN--MMVTECTATRVGGFGDTVPFTLIENGCP--RYPALVGPVEQDFDkNRLKSDL 603
Cdd:smart00241 138 PYQSAdyvLGDPVYHEWECDGADDPPlgLLVDNCYATPGPDPSSGPKYFIIDNGCPvdGYLDSTIPYNSNPL-HRARFSV 216

                          250       260       270
                   ....*....|....*....|....*....|...
gi 17540572    604 RAFRLDGSYDVQIVCSIMFC--AGPNGCPVSNC 634
Cdd:smart00241 217 KVFKFADRSLVYFHCQIRLCdkDDGSSCDGPAC 249
PAN_1 pfam00024
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
 310-382 3.84e-09

PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.


Pssm-ID: 459635  Cd Length: 76  Bit Score: 53.71  E-value: 3.84e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17540572   310 AFERFIGSSIEGEVVASAQGVTISDCISLCFQNLNCKSINYDRTASSCFIYAVGRQDAN--IKANPSMDYYEFNC 382
Cdd:pfam00024   2 DFERVPGSSLSGVDVSTVTVSSAEECAQRCTNEPRCRSFTYNPKSKKCHLKSSSSGSLPrlKRSDNKVDYYEKSC 76
PAN_1 pfam00024
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
 220-295 5.40e-09

PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.


Pssm-ID: 459635  Cd Length: 76  Bit Score: 53.33  E-value: 5.40e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17540572   220 FVKTTNFEIRYYDHTQSVEAQESYCLQKCLDslNTFCRSVEFNPKEKNCIVSDEDTFSRADQQGQVVGKDYYEPIC 295
Cdd:pfam00024   3 FERVPGSSLSGVDVSTVTVSSAEECAQRCTN--EPRCRSFTYNPKSKKCHLKSSSSGSLPRLKRSDNKVDYYEKSC 76
Zona_pellucida pfam00100
Zona pellucida-like domain;
392-634 7.09e-09

Zona pellucida-like domain;


Pssm-ID: 459673 [Multi-domain]  Cd Length: 254  Bit Score: 57.23  E-value: 7.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540572   392 CTNEGIRFIVNTKEPYTGAIYAA-----ERFSTCSQVVENAKQISITFPPPtvSSDCGTVIR--DGKM--EALVVVSLDG 462
Cdd:pfam00100   1 CTPDTMTVSISKCLLVPSGLLSSlsllgGLDPSCKPVSNTNGSPAVLFEFP--LTGCGTTVQvnGTHIiySNTLYSSTDL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540572   463 VLPHQVTTEWDRFYrVSCDVSMDKMVKEGSVVVTTIYEASSQNTTVLDVatpppvsaELQILN------QLEEPLHKASI 536
Cdd:pfam00100  79 RSGIIRRTITRRLP-FSCSYPRSSLVSLLVVAPPSPVPITVSGSGVFLV--------SMDLYYdssytsPYSPYPVTVLL 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540572   537 GDPLLLVITSEQAGPHN--MMVTECTATRVGGFGDTVPFTLIENGCPRYPALVGPVEQDFDKNRLKS--DLRAFRLDGSY 612
Cdd:pfam00100 150 GDPLYVEVSLLSRTDPNlvLVLDNCWATPSPNPTSSPQYQLIVNGCPNDGDSTYPVSSLSNGPSHYVrfSFKAFRFVGSS 229

                         250       260
                  ....*....|....*....|....
gi 17540572   613 D--VQIVCSIMFCAGPNGCPVSNC 634
Cdd:pfam00100 230 IsqVYLHCSVSVCSSDSNSCGKSC 253
PAN_AP smart00473
divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans ...
 310-379 1.16e-08

divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans hypothetical ORFs and the extracellular portion of plant receptor-like protein kinases. Predicted to possess protein- and/or carbohydrate-binding functions.


Pssm-ID: 214680  Cd Length: 78  Bit Score: 52.58  E-value: 1.16e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17540572    310 AFERFIGSSIEGEVVASAQGVTISDCISLCFQ-NLNCKSINYDRTASSCFIYAVGR-QDANIKANPSMDYYE 379
Cdd:smart00473   5 CFVRLPNTKLPGFSRIVISVASLEECASKCLNsNCSCRSFTYNNGTKGCLLWSESSlGDARLFPSGGVDLYE 76
PAN_1 pfam00024
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
 28-112 1.53e-05

PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.


Pssm-ID: 459635  Cd Length: 76  Bit Score: 43.70  E-value: 1.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540572    28 AFVRIPRARLDGTPVVISTAGHDLTCAQYCRNNIEpttgaqrvCASFNFD-GRETCYFFDDAATPAGTSQLTANpsaNNF 106
Cdd:pfam00024   2 DFERVPGSSLSGVDVSTVTVSSAEECAQRCTNEPR--------CRSFTYNpKSKKCHLKSSSSGSLPRLKRSDN---KVD 70


                  ....*.
gi 17540572   107 YYEKTC 112
Cdd:pfam00024  71 YYEKSC 76
PAN_AP smart00473
divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans ...
 25-111 4.42e-05

divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans hypothetical ORFs and the extracellular portion of plant receptor-like protein kinases. Predicted to possess protein- and/or carbohydrate-binding functions.


Pssm-ID: 214680  Cd Length: 78  Bit Score: 42.18  E-value: 4.42e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540572     25 ETTAFVRIPRARLDGTPVVISTAGHDLTCAQYCRNNiepttgaQRVCASFNFD-GRETCYFFDDaatpAGTSQLTANPSA 103
Cdd:smart00473   2 SDDCFVRLPNTKLPGFSRIVISVASLEECASKCLNS-------NCSCRSFTYNnGTKGCLLWSE----SSLGDARLFPSG 70


                   ....*...
gi 17540572    104 NNFYYEKT 111
Cdd:smart00473  71 GVDLYEKI 78
PAN_AP_HGF cd01099
Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen ...
 310-379 1.44e-03

Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


Pssm-ID: 238532  Cd Length: 80  Bit Score: 38.22  E-value: 1.44e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17540572 310 AFERFIGSSIEGEVVASAQGVTISDCISLCFQNLN--CKSINYDRTASSCFIYAVGRQDANIKA--NPSMDYYE 379
Cdd:cd01099   5 KFVLVLNKILVSEVKTEITVASLEECLRKCLEETEftCRSFNYNYKSKECILSDEDRMSSGVKLlyDSNVDYYE 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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