NCBI Conserved Domain Search

Conserved domains on [gi|17539092|ref|NP_502513|]

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Major facilitator superfamily (MFS) profile domain-containing protein [Caenorhabditis elegans]

Protein Classification

spinster family MFS transporter( domain architecture ID 13023647)

spinster family major facilitator superfamily (MFS) transporter may function as a sphingolipid transporter that plays a central role in endosome and/or lysosome storage

CATH: 1.20.1250.20

Gene Ontology: GO:0022857|GO:0055085|GO:0006869

PubMed: 26758938|26098515

SCOP: 3000310

TCDB: 2.A.1.49

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

MFS_spinster_like

cd17328

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...

11-440

3.33e-158

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 454.77 E-value: 3.33e-158

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  11 VTALFVVNLLNYVDRYTVAGVLTQVQTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLG 90
Cdd:cd17328   1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  91 SSFVPanHFWLFLVLRSFVGIGEASYSNVAPSLISDMFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVATLTGHWQWGIR 170
Cdd:cd17328  81 SSFAP--NFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFR 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 171 VSAIAGLIVMIALVLFTYEPERGAADKAMGESkdvvvTTNTTYLEDLVILLKTPTLVACTWGYTALVFVSGTLSWWEPTV 250
Cdd:cd17328 159 VTGVLGVLLAILLLLFVREPPRGAAEGGVMAK-----STATSFLADLKALAKNPSFILSTLGFTAVSFVTGALAFWAPTF 233

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 251 IQHLTAWhqglndtkdlASTDKDRVALYFGAITTAGGLIGVIFGSMLSKWLVAGwgpfrrlqTDRAQPLVAGGGALLAAP 330
Cdd:cd17328 234 FLRAFGV----------GDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRK--------TPRADPLVCAVGLLAAAP 295

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 331 FLLIGMIFGDKSLVLLYIMIFFGITFMCFNWGLNIDMLTTVIHPNRRSTAFSYFVLVSHLFGDASGPYLIGLISDAIRHG 410
Cdd:cd17328 296 FLFLALVLALSNLLLAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHLLGDAGSPYLIGLISDLLRQN 375

                       410       420       430
                ....*....|....*....|....*....|
gi 17539092 411 STYPKDQYHSLVSATYCCVALLLLSAGLYF 440
Cdd:cd17328 376 KDSPLAEAASLQYALLLCSFVLVLGGFFFL 405

Name

Accession

Description

Interval

E-value

MFS_spinster_like

cd17328

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...

11-440

3.33e-158

Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 454.77 E-value: 3.33e-158

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  11 VTALFVVNLLNYVDRYTVAGVLTQVQTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLG 90
Cdd:cd17328   1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  91 SSFVPanHFWLFLVLRSFVGIGEASYSNVAPSLISDMFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVATLTGHWQWGIR 170
Cdd:cd17328  81 SSFAP--NFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFR 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 171 VSAIAGLIVMIALVLFTYEPERGAADKAMGESkdvvvTTNTTYLEDLVILLKTPTLVACTWGYTALVFVSGTLSWWEPTV 250
Cdd:cd17328 159 VTGVLGVLLAILLLLFVREPPRGAAEGGVMAK-----STATSFLADLKALAKNPSFILSTLGFTAVSFVTGALAFWAPTF 233

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 251 IQHLTAWhqglndtkdlASTDKDRVALYFGAITTAGGLIGVIFGSMLSKWLVAGwgpfrrlqTDRAQPLVAGGGALLAAP 330
Cdd:cd17328 234 FLRAFGV----------GDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRK--------TPRADPLVCAVGLLAAAP 295

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 331 FLLIGMIFGDKSLVLLYIMIFFGITFMCFNWGLNIDMLTTVIHPNRRSTAFSYFVLVSHLFGDASGPYLIGLISDAIRHG 410
Cdd:cd17328 296 FLFLALVLALSNLLLAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHLLGDAGSPYLIGLISDLLRQN 375

                       410       420       430
                ....*....|....*....|....*....|
gi 17539092 411 STYPKDQYHSLVSATYCCVALLLLSAGLYF 440
Cdd:cd17328 376 KDSPLAEAASLQYALLLCSFVLVLGGFFFL 405

UhpC

COG2271

Sugar phosphate permease [Carbohydrate transport and metabolism];

8-406

2.13e-33

Sugar phosphate permease [Carbohydrate transport and metabolism];

Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 129.60 E-value: 2.13e-33

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092   8 YISVTALFVVNLLNYVDRYTVAGVLTQVQTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGA 87
Cdd:COG2271   9 WRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLA 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  88 VLGSSFVPAnhFWLFLVLRSFVGIGEASYSNVAPSLISDMFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVATLTGhWQW 167
Cdd:COG2271  89 TLLFGFATS--FWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFG-WRA 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 168 GIRVSAIAGLIVMIAlvlftyepergaadkamgeskdvvvttnttyledlvillktpTLVACTWGYTALVFVSGTLSWWE 247
Cdd:COG2271 166 AFLILGLPGLLLALL------------------------------------------RFWLLALAYFLVYFALYGFLTWL 203

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 248 PTVIQHltawHQGLNDTKdlastdkdrvALYFGAITTAGGLIGVIFGSMLSKWLvagwgpfrrlqtDRAQPLVAGGGALL 327
Cdd:COG2271 204 PTYLVE----VRGLSLAQ----------AGLLLSLPFLAGIVGSLLGGWLSDRL------------GRRRKLVLAIGLLL 257

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17539092 328 AAPFLLIGMIFGdkSLVLLYIMIFFGITFMCFNWGLNIDMLTTVIHPNRRSTAFSyFVLVSHLFGDASGPYLIGLISDA 406
Cdd:COG2271 258 AALALLLLALLP--SPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASG-LVNTFGFLGGALGPLLVGYLLDA 333

MFS_1

pfam07690

Major Facilitator Superfamily;

14-390

1.42e-24

Major Facilitator Superfamily;

Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 104.42 E-value: 1.42e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092    14 LFVVNLLNYVDRYTVAGVLTQ-VQTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLGSS 92
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092    93 FvpANHFWLFLVLRSFVGIGEASYSNVAPSLISDMFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVATLTGhWQWGIRVS 172
Cdd:pfam07690  81 F--ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAAFLIL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092   173 AIAGLIVMIALVLFTYEPERGAADKAMGESKDVVVTTNttyledlviLLKTPTLVACTWGYTALVFVSGTLSWWEPTVIQ 252
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWK---------ALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQE 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092   253 HLtawhqGLNDTkdlastdkdrVALYFGAITTAGGLIGVIFGSMLSKWLvagwgpfrrlqtDRAQPLVAGGGALLAAPFL 332
Cdd:pfam07690 229 VL-----GLSAL----------LAGLLLGLGGLLGAIGRLLLGRLSDRL------------GRRRRLLLALLLLILAALG 281

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 17539092   333 LIGMIFGDKSLVLLYIMIFFGITFMcFNWGLNIDMLTTVIHPNRRSTAFSYFVLVSHL 390
Cdd:pfam07690 282 LLLLSLTLSSLWLLLALLLLGFGFG-LVFPALNALVSDLAPKEERGTASGLYNTAGSL 338

2_A_01_02

TIGR00880

Multidrug resistance protein;

47-186

7.37e-13

Multidrug resistance protein;

Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 65.75 E-value: 7.37e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092    47 GLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWlgAVLGSSFVPANHFWLFLVLRSFVGIGEASYSNVAPSLISD 126
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIF--VLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIAD 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092   127 MFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVATLTGhWQWGIRVSAIAGLIVMIALVLF 186
Cdd:TIGR00880  79 IYPPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLG-WRAPFLFLAILALAAFILLAFL 137

PRK08633

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated

48-203

2.48e-05

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated

Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 47.23 E-value: 2.48e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092    48 LIQTVFLISFMVFSPVCGYLGDRFNRKWIMII----GVGIWLGAVLGSSFvpaNHFWLFLVLRSFVGIGEASYS----NV 119
Cdd:PRK08633   51 IVNALFLLPFLLLSSPAGFLADKFSKNRVIRIvklfEVGLTLLIVLAYYL---GWFWLAFAVTFLLGAQSAIYSpakyGI 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092   120 APSLISDMFNGQKRSTVFMIFYFAIPVGSGLG-FIVGSNVATLTGHWQWGIRVSAIAGLIVMIALVLFTYEPERGAADKA 198
Cdd:PRK08633  128 IPELVGKENLSRANGLLEAFTIVAILAGTALFsFLFESVNGNTPSEILGRIAPAGLVLLAVAVLGLIFAYRLPKVPAAAP 207


                  ....*
gi 17539092   199 MGESK 203
Cdd:PRK08633  208 EVFDK 212

Name

Accession

Description

Interval

E-value

MFS_spinster_like

cd17328

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...

11-440

3.33e-158

Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 454.77 E-value: 3.33e-158

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  11 VTALFVVNLLNYVDRYTVAGVLTQVQTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLG 90
Cdd:cd17328   1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  91 SSFVPanHFWLFLVLRSFVGIGEASYSNVAPSLISDMFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVATLTGHWQWGIR 170
Cdd:cd17328  81 SSFAP--NFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFR 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 171 VSAIAGLIVMIALVLFTYEPERGAADKAMGESkdvvvTTNTTYLEDLVILLKTPTLVACTWGYTALVFVSGTLSWWEPTV 250
Cdd:cd17328 159 VTGVLGVLLAILLLLFVREPPRGAAEGGVMAK-----STATSFLADLKALAKNPSFILSTLGFTAVSFVTGALAFWAPTF 233

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 251 IQHLTAWhqglndtkdlASTDKDRVALYFGAITTAGGLIGVIFGSMLSKWLVAGwgpfrrlqTDRAQPLVAGGGALLAAP 330
Cdd:cd17328 234 FLRAFGV----------GDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRK--------TPRADPLVCAVGLLAAAP 295

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 331 FLLIGMIFGDKSLVLLYIMIFFGITFMCFNWGLNIDMLTTVIHPNRRSTAFSYFVLVSHLFGDASGPYLIGLISDAIRHG 410
Cdd:cd17328 296 FLFLALVLALSNLLLAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHLLGDAGSPYLIGLISDLLRQN 375

                       410       420       430
                ....*....|....*....|....*....|
gi 17539092 411 STYPKDQYHSLVSATYCCVALLLLSAGLYF 440
Cdd:cd17328 376 KDSPLAEAASLQYALLLCSFVLVLGGFFFL 405

UhpC

COG2271

Sugar phosphate permease [Carbohydrate transport and metabolism];

8-406

2.13e-33

Sugar phosphate permease [Carbohydrate transport and metabolism];

Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 129.60 E-value: 2.13e-33

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092   8 YISVTALFVVNLLNYVDRYTVAGVLTQVQTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGA 87
Cdd:COG2271   9 WRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLA 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  88 VLGSSFVPAnhFWLFLVLRSFVGIGEASYSNVAPSLISDMFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVATLTGhWQW 167
Cdd:COG2271  89 TLLFGFATS--FWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFG-WRA 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 168 GIRVSAIAGLIVMIAlvlftyepergaadkamgeskdvvvttnttyledlvillktpTLVACTWGYTALVFVSGTLSWWE 247
Cdd:COG2271 166 AFLILGLPGLLLALL------------------------------------------RFWLLALAYFLVYFALYGFLTWL 203

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 248 PTVIQHltawHQGLNDTKdlastdkdrvALYFGAITTAGGLIGVIFGSMLSKWLvagwgpfrrlqtDRAQPLVAGGGALL 327
Cdd:COG2271 204 PTYLVE----VRGLSLAQ----------AGLLLSLPFLAGIVGSLLGGWLSDRL------------GRRRKLVLAIGLLL 257

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17539092 328 AAPFLLIGMIFGdkSLVLLYIMIFFGITFMCFNWGLNIDMLTTVIHPNRRSTAFSyFVLVSHLFGDASGPYLIGLISDA 406
Cdd:COG2271 258 AALALLLLALLP--SPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASG-LVNTFGFLGGALGPLLVGYLLDA 333

AraJ

COG2814

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

9-395

9.30e-29

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 116.23 E-value: 9.30e-29

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092   9 ISVTALFVVNLLNYVDRYTVAGVLTQVQTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAV 88
Cdd:COG2814  10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  89 LGSSFvpANHFWLFLVLRSFVGIGEASYSNVAPSLISDMFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVATLTGhWQWG 168
Cdd:COG2814  90 LLCAL--APSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG-WRWV 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 169 IRVSAIAGLIVMIALVLFTYEPERGAADKAMGESKDvvvttnttyledlviLLKTPTLVACTWGYTALVFVSGTLSWWEP 248
Cdd:COG2814 167 FLVNAVLALLALLLLLRLLPESRPAARARLRGSLRE---------------LLRRPRLLLLLLLAFLLGFGFFALFTYLP 231

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 249 TVIQHLTAWHQGLndtkdlastdkdrVALYFGAITtagglIGVIFGSMLSKWLVAGWGPFRrlqtdraqpLVAGGGALLA 328
Cdd:COG2814 232 LYLQEVLGLSASA-------------AGLLLALFG-----LGGVLGALLAGRLADRFGRRR---------LLLIGLLLLA 284

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17539092 329 APFLLIGMIFGDKSLVLLYIMIFFGITFMcfnWGLNIDMLTTVIHPNRRSTAFSYFVLVSHLFGDAS 395
Cdd:COG2814 285 LGLLLLALAGSLWLLLLALFLLGFGFGLL---FPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348

MFS_1

pfam07690

Major Facilitator Superfamily;

14-390

1.42e-24

Major Facilitator Superfamily;

Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 104.42 E-value: 1.42e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092    14 LFVVNLLNYVDRYTVAGVLTQ-VQTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLGSS 92
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092    93 FvpANHFWLFLVLRSFVGIGEASYSNVAPSLISDMFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVATLTGhWQWGIRVS 172
Cdd:pfam07690  81 F--ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAAFLIL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092   173 AIAGLIVMIALVLFTYEPERGAADKAMGESKDVVVTTNttyledlviLLKTPTLVACTWGYTALVFVSGTLSWWEPTVIQ 252
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWK---------ALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQE 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092   253 HLtawhqGLNDTkdlastdkdrVALYFGAITTAGGLIGVIFGSMLSKWLvagwgpfrrlqtDRAQPLVAGGGALLAAPFL 332
Cdd:pfam07690 229 VL-----GLSAL----------LAGLLLGLGGLLGAIGRLLLGRLSDRL------------GRRRRLLLALLLLILAALG 281

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 17539092   333 LIGMIFGDKSLVLLYIMIFFGITFMcFNWGLNIDMLTTVIHPNRRSTAFSYFVLVSHL 390
Cdd:pfam07690 282 LLLLSLTLSSLWLLLALLLLGFGFG-LVFPALNALVSDLAPKEERGTASGLYNTAGSL 338

MFS

cd06174

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...

14-440

4.07e-24

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.

Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 103.66 E-value: 4.07e-24

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  14 LFVVNLLNYVDRYTVAGVLTQVQTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLGSSF 93
Cdd:cd06174   1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  94 VPanHFWLFLVLRSFVGIGEASYSNVAPSLISDMFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVAT-LTGHWQWGIRVS 172
Cdd:cd06174  81 AP--SFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASsLGFGWRAVFLIA 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 173 AIAGLIVMIALVLFTYEPERGAadkamgeSKDVVVTTNTTYLEDLVILLKTPTLVACTWGYTALVFVSGTLSWWEPTVIQ 252
Cdd:cd06174 159 AALALLAAILLLLVVPDPPESA-------RAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLL 231

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 253 HLTAWhqglndtkdlastdKDRVALYFGAITTAGGLIGVIFGSMLSKWLVAGWgpfrrlqtdraqPLVAGGGALLAAPFL 332
Cdd:cd06174 232 DLGGL--------------SVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRK------------PLLLIGLLLMALGLA 285

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 333 LIGMIFGDKSLVLLYIMIFFGITFMcfnWGLNIDMLTTVIHPNRRSTAFSYFVLVSHLfGDASGPYLIGLISDAirhgst 412
Cdd:cd06174 286 LLLLAPSLLLLLLLLLLLGFGLGGL---LPLSFALIAELFPPEIRGTAFGLLNTFGFL-GGAIGPLLAGFLLAA------ 355

                       410       420
                ....*....|....*....|....*...
gi 17539092 413 ypkdqYHSLVSATYCCVALLLLSAGLYF 440
Cdd:cd06174 356 -----TFGLTGAFLVLAVLLLLAAILLL 378

MFS_ExuT_GudP_like

cd17319

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...

8-441

3.44e-22

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 97.64 E-value: 3.44e-22

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092   8 YISVTALFVVNLLNYVDRYTVAGVLTQVQTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGA 87
Cdd:cd17319   2 WRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  88 VLGSSFVpaNHFWLFLVLRSFVGIGEASYSNVAPSLISDMFNGQKRSTVFMIFYFAIPVGSGLGFIVgSNVATLTGHWQW 167
Cdd:cd17319  82 TALTGFA--TSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPL-SGWLLLLFGWRW 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 168 GIRVSAIAGLIVMIaLVLFTYepergaadkamgeskdvvvttnttyledlvillktPTLVACTWGYTALVFVSGTLSWWE 247
Cdd:cd17319 159 AFIIEGLLGLLLAV-LWWFYL-----------------------------------RQVWGLALGYFGINYALYGLLTWL 202

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 248 PTVIQHLtawhQGLNDTKdlastdkdrvALYFGAITTAGGLIGVIFGSMLSKWLVAGwgpfrrlqtdrAQPLVAGGGALL 327
Cdd:cd17319 203 PTYLKQA----RGFSLKQ----------VGLLAAIPFLAGAIGMILGGRLSDRLLRG-----------ARRLVIIIGLLL 257

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 328 AAPFLLIGMIFGdkSLVLLYIMIFFGITFMCFNWGLNIDMLTTVIHPNRRSTAFSYFVLVSHLfGDASGPYLIGLIsdai 407
Cdd:cd17319 258 AAVGLLLAYLTT--SPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNL-GGFVAPLLIGYL---- 330

                       410       420       430
                ....*....|....*....|....*....|....
gi 17539092 408 rhgstypKDQYHSLVSATYCCVALLLLSAGLYFV 441
Cdd:cd17319 331 -------VDATGSYTAAFLFLAAVALLAALLVLL 357

NarK

COG2223

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];

11-406

4.69e-21

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];

Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 94.95 E-value: 4.69e-21

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  11 VTALFVVNLLNYVDRYTVAGVLTQVQTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLG 90
Cdd:COG2223   7 LLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLL 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  91 SSFvpANHFWLFLVLRSFVGIGEASYSNVAPSLISDMFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVATLTGhWQWGIR 170
Cdd:COG2223  87 LAL--AVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFG-WRNAFL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 171 VSAIAGLIVMIALVLFTYEPERGAADKAMGEskdvvvttnttyLEDLVILLKTPTLVACTWGYTALVFVSGTLSWWEPTV 250
Cdd:COG2223 164 ILGILLLVVAVLAWLFLRDPPAGAAAAAKAS------------LRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPY 231

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 251 IQhltawhqglndtkDLASTDKDRVALYFGAITTAGGLIGVIFGsmlskWLVAGWGPFRRLqtdraqpLVAGGGALLAap 330
Cdd:COG2223 232 LV-------------DQFGLSAATAGLLAALFALLGALGRPLGG-----WLSDRIGGRRVL-------LIVFALMALG-- 284

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17539092 331 flLIGMIFGDKSLVLLYIMIFFGITFMCFNWGLNIDMLTTvIHPNRRSTAFSYFVLVSHLFGDASGPYLIGLISDA 406
Cdd:COG2223 285 --LLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPD-IFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDA 357

MFS_NepI_like

cd17324

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...

11-433

9.81e-18

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 84.52 E-value: 9.81e-18

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  11 VTALFVVNLLNYVDRYTVAGVLTQVQTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLG 90
Cdd:cd17324   1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  91 SSFvpANHFWLFLVLRSFVGIGEASYSNVAPSLISDMFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVATLTGhWQWGIR 170
Cdd:cd17324  81 AAL--APSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLG-WRAAFL 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 171 VSAIAGLIVMIALVLFTyepERGAADKAmgeskdvvvtTNTTYLEDLVILLKTPTLVACTwGYTALVFVSGTLSWwepTV 250
Cdd:cd17324 158 AIAVLALLAALLLWRLL---PSLPPKKP----------GSLGLLSSLLLLLRNPRLRLAY-LITFLLFGGFFALY---TY 220

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 251 IQ-HLTAWHQGLNDTkdlastdkdrVALYFGAIttagGLIGVIfGSMLSKWLVAGWGpfrrlqtdrAQPLVAGGGALLAA 329
Cdd:cd17324 221 LApFLTDVPGFSSSA----------IIGLLLLF----GVAGVV-GSPLAGRLADRGG---------RRALLIALLLLAAA 276

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 330 PFLLigMIFGDKSLVLLYIMIFFGITFMCFNWGLNidMLTTVIHPNRRSTAFSYFVLVSHLfGDASGPYLIGLISDAIrh 409
Cdd:cd17324 277 LLLL--TLLGPSPLLLLVGLVLWGLGFFAAHSALQ--TRVLRLAPEARGLASSLYLAAYNL-GGALGAALGGLVLDHG-- 349

                       410       420
                ....*....|....*....|....
gi 17539092 410 GSTYPkdqyhSLVSATYCCVALLL 433
Cdd:cd17324 350 GWAGV-----GWVGAALLLLALLL 368

MFS_MdtG_SLC18_like

cd17325

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...

42-441

1.07e-17

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 84.55 E-value: 1.07e-17

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  42 SDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLGSSFvpANHFWLFLVLRSFVGIGEASYSNVAP 121
Cdd:cd17325  29 SVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF--ATSYWQLLLARFLQGLASAAVWPAAM 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 122 SLISDMFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVATLTGhWQWGIRVSAIAGLIVMIALVLFTYEPERGAADKAMGE 201
Cdd:cd17325 107 ALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG-YRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSA 185

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 202 SKDvvvttnttyLEDLVILLKTPTLVACTWGYTALVFVSGTLswwEPTVIQHLTawhqglndtkDLASTDKDRVALYFGA 281
Cdd:cd17325 186 ARL---------RSGLRLLLRDRRLLALFLAIFVLAFAFGAL---EPFLPLYAA----------ELGGLSPAQIGLLFGA 243

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 282 ITTAGGLIGVIFGsmlskWLVAGWGPFrrlqtdraqPLVAGGGALLAAPFLLIGMIFGDKSLVLLYIMIFFGITFMCFNW 361
Cdd:cd17325 244 QGLASALSQPPAG-----KLSDRIGRK---------PLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPAT 309

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 362 GLnidMLTTVIHPNRRSTAFSYFVLVSHLfGDASGPYLIGLISDAIRHGSTYpkdqyhslvsatYCCVALLLLSAGLYFV 441
Cdd:cd17325 310 LA---LLADIVPPEGRGTAMGLFNTAFSL-GMVLGPLLGGFLYDAFGFATPF------------LAAAALLLLAAVLFLL 373

MFS_YfmO_like

cd17474

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...

11-440

1.49e-17

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 84.16 E-value: 1.49e-17

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  11 VTALFVVNLLNYVDRYTVAGVLTQVQTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLG 90
Cdd:cd17474   1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  91 SSFvpANHFWLFLVLRSFVGIGEASYSNVAPSLISDMFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVATLtgHWQWGIR 170
Cdd:cd17474  81 CGL--SDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI--SWRYPFF 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 171 VSAIAGLIVMIALVLFTYEPERGAadkamgeskdvvVTTNTTYLEDLVILLKTPTLVACTWGYTALVFVSGTLSWWEPTV 250
Cdd:cd17474 157 LLAALIPVAFLAILFLLPEPKEKA------------KSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFL 224

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 251 iqhltawhqgLNDTKDLASTDKdrvalyfGAITTAGGLIGVIFGSMLSKWLVAGWGpfrrlqtdrAQPLVAGGGALLAAP 330
Cdd:cd17474 225 ----------LELLYGISPIII-------GLLFAGWSVLLALGSLFVGRLLKKRFG---------ARRILVIGLLLYALS 278

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 331 FLLIGmiFGDKSLVLLYIMIFFGITFMCFNWGLNiDMLTTVIHPNRRSTAFSYFVLVSHLfGDASGPYLIGLISdairhg 410
Cdd:cd17474 279 LLLLG--FVPSLALLLIAIVLFGLGLGLNLPLLT-TLVTELAPEEERGTASSLYNFVRFL-GQAVGPLLFGLLL------ 348

                       410       420       430
                ....*....|....*....|....*....|
gi 17539092 411 stypkdQYHSLVSATYCCVALLLLSAGLYF 440
Cdd:cd17474 349 ------EIFGLSAPFLVGAAIALAAAVLLA 372

MFS_arabinose_efflux_permease_like

cd17473

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...

27-404

1.20e-16

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 81.47 E-value: 1.20e-16

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  27 TVAGVLTQVQTYY-NISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGvgIWLGAVLGSSFVPANHFWLFLVL 105
Cdd:cd17473  17 AIAPALPAIAQHFvPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAG--LLLYGIGGVAGLFLDSLYALLAS 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 106 RSFVGIGEASYSNVAPSLISDMFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVATLtgHWQWGIRVSAIAgLIVMIALVL 185
Cdd:cd17473  95 RALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEI--GWRAPFLVYLLA-LPVLILVLL 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 186 FTYEPERgaadkAMGESKDVVVTTNTTYLEDLVillktptlvactWGYTALVFVSGTLSWWEPTVIQHLTAWHQGLNdtk 265
Cdd:cd17473 172 FLPEPAR-----KSKSAASPGAATAAALPWKRV------------LPIYFLAFLAMLLFYVIPIQLPFLLQERGGGS--- 231

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 266 dlastdkdrvALYFGAITTAGGLIGVIfGSMLSKWLVAGWGPfrrlqtdraQPLVAGGGALLAAPFLLIGmifgdksLVL 345
Cdd:cd17473 232 ----------AALIGLALAIASLAGAI-GALLFGRLKRRLGK---------RRLLAIGFALMALGFLLLA-------LAS 284

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17539092 346 LYIMIFFGITFMCFNWGLNI----DMLTTVIHPNRRSTAFSYFVLvSHLFGDASGPYLIGLIS 404
Cdd:cd17473 285 GLWVVLLGAILAGLGFGLLLptlnSWAMSLVPPELRGRAMGIVTS-AFFLGQFLSPLVLGPLV 346

ProP

COG0477

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...

11-257

2.63e-16

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];

Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 79.47 E-value: 2.63e-16

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  11 VTALFVVNLLNYVDRYTVAGVLTQVQTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLG 90
Cdd:COG0477  16 LLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLL 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  91 SSFVPAnhFWLFLVLRSFVGIGEASYSNVAPSLISDMFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVATLTGhWQWGIR 170
Cdd:COG0477  96 CGLAPS--PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALG-WRWIFL 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 171 VSAIAGLIVMIALVLFTYEPERGAADKAMGESKDVVVTTNTTYLEDLVILLKTPTLVACTWGYTALVFVSGTLSWWEPTV 250
Cdd:COG0477 173 INAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLL 252


                ....*..
gi 17539092 251 IQHLTAW 257
Cdd:COG0477 253 LLALLLL 259

FucP

COG0738

Fucose permease [Carbohydrate transport and metabolism];

8-407

5.49e-16

Fucose permease [Carbohydrate transport and metabolism];

Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 79.51 E-value: 5.49e-16

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092   8 YISVTALFVVNLLNYVdryTVAGVLTQVQTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGA 87
Cdd:COG0738  10 LIAIYLLFFLWGFATA---LWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALG 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  88 VLGSSFVPanHFWLFLVLRSFVGIGEASYSNVAPSLISDMFnGQKRSTVFMIFYFAIPVGSGLGFIVGSNVATLTGHWQW 167
Cdd:COG0738  87 LLLFALAP--SYPLLLLALFLLGLGLGLLDVAANPYVAALG-PETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSW 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 168 GIRVSAIAGLIVMIALVLFTYEPERGAADKAMGESKDVVVTTnttyledlviLLKTPTLVACTWGYTALVFVSGTLSWWE 247
Cdd:COG0738 164 HLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKS----------LLKNPRLLLGGLAIFLYVGAEGAIGDWL 233

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 248 PTVIqhltawhqglndtKDLASTDKDRVALYFgAITTAGGLIGVIFGSMLSKWLvagwgpfrrlqtdRAQPLVAGGGALL 327
Cdd:COG0738 234 PLYL-------------KDVLGLSEATAALGL-SLFWGGMTIGRFLGGFLLKRF-------------GPVRLLRLSALLA 286

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 328 AApfLLIGMIFGDKSLVLLYIMIFFGItFMCFNWGLnIDMLTTVIHPNRRSTAFSyFVLVSHLFGDASGPYLIGLISDAI 407
Cdd:COG0738 287 AV--GLLLALLAPGPWLALIGLALVGL-GLSLMFPT-IFSLALDGLGKRTAAAVS-AVLIMGIVGGAIGPPLIGFLADAF 361

MFS_Tpo1_MDR_like

cd17323

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...

29-186

1.96e-14

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 74.53 E-value: 1.96e-14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  29 AGVLTQVQTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLGSSFvpANHFWLFLVLRSF 108
Cdd:cd17323  19 SPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCAL--APNIAMLIILRFL 96

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17539092 109 VGIGEASYSNVAPSLISDMFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVATLTGhWQWGIRVSAIAGLIVMIALVLF 186
Cdd:cd17323  97 QGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLG-WRWIFWFLAIISGFCLILIFLF 173

MFS_MMR_MDR_like

cd17504

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...

28-436

2.02e-14

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 74.54 E-value: 2.02e-14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  28 VAGVLTQVQTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLGSSFVPAnhFWLFLVLRS 107
Cdd:cd17504  15 LSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPN--LPVLIAGRA 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 108 FVGIGEASYSnVAPSLISDMFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVATLTGhWQWGIRVSAIAGLIVMIALVLFt 187
Cdd:cd17504  93 LQGIGGAVFP-LAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLG-WRWIFWTAAPVAVLLAALVPLI- 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 188 yepergaadkamgeskdvvvttnttyleDLVILLKTPTLVACTwgyTALVFVSGTLswwepTVIQHLTAWHQglndtkdl 267
Cdd:cd17504 170 ----------------------------DLRLLRRRNVLLANI---TALLAGFGMF-----MVFQLLPQLLQ-------- 205

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 268 astdkDRVALYFGAITTAGGL------IGVIFGSMLSKWLVAGWGPFRrlqtdraqplVAGGGALLAAPFLLIGMIFGDK 341
Cdd:cd17504 206 -----LPTPTGFGLGITEAGLlllpgaLVMLIAGPLAGRLIARVGPRR----------VLLIGLVISAVGLLLLALLHSS 270

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 342 SLVLLYIMIFFGITFMCFNWGLnIDMLTTVIHPNRRSTAFSyFVLVSHLFGDASGPYLIGLI----SDAIRHGSTYPKDQ 417
Cdd:cd17504 271 LWALVVALLLIGIGLGLAFASL-PNIVVESVPPDRTGIATG-MNTVLRTIGSAIGPAIAGAIlttyTVSITSGGVPTEGA 348

                       410       420
                ....*....|....*....|
gi 17539092 418 YH-SLVSATYCCVALLLLSA 436
Cdd:cd17504 349 YVlAFLIGAALALAALLLSL 368

MelB

COG2211

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];

14-186

4.01e-14

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];

Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 74.17 E-value: 4.01e-14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  14 LFVVNLLNYVDRYTVAGVLTQVQTYY-NISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLGSS 92
Cdd:COG2211 233 LLLAYLLFFLALALVAALLLYYFKYVlGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLF 312

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  93 FVPANHFWLFLVLRSFVGIGEASYSNVAPSLISDM------FNGQKRSTVFM-IFYFAIPVGSGLGFIVGSNVATLTG-- 163
Cdd:COG2211 313 FLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVvdydewKTGRRREGLYFgIFTFAIKLGQALAGALAGLLLALFGyv 392

                       170       180       190
                ....*....|....*....|....*....|..
gi 17539092 164 -------HWQWGIRV--SAIAGLIVMIALVLF 186
Cdd:COG2211 393 agaaqspSALTGIRLlfFLLPAVLLLLAALLL 424

CynX

COG2807

Cyanate permease [Inorganic ion transport and metabolism];

26-406

1.26e-13

Cyanate permease [Inorganic ion transport and metabolism];

Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 72.21 E-value: 1.26e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  26 YTVAGVLTQVQTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLGSSFVPanHFWLFLVL 105
Cdd:COG2807  35 TSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAP--SVALLLAG 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 106 RSFVGIGEASYSNVAPSLISDMFnGQKRSTVFMIFYFAIPVGSGLGFIVGSNVATLTGhWQWGIRVSAIAGLIVMIALVL 185
Cdd:COG2807 113 TALIGAGIAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALG-WRGALAVWALLALLALLLWLP 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 186 FTYEPERGAADKAMGESkdvvvttnttyledLVILLKTPT--LVACTWGYTALVFvSGTLSWWePTVIQhltawHQGLND 263
Cdd:COG2807 191 LLRRRPAAAAAAPAAAS--------------LRSLWRSPLawLLTLFFGLQSLLY-YAVVAWL-PPILR-----DAGLSA 249

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 264 tkdlastdkdrvalyfgaiTTAGGLIGV-----IFGSMLSKWLVAGWGPFRrlqtdraqPLVAGGGALLAAPFLliGMIF 338
Cdd:COG2807 250 -------------------ATAGLLLSLfqlagIPGSLLVPLLADRLGDRR--------PLLLLLGLLGLAGLL--GLLL 300

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17539092 339 GDKSLVLLYiMIFFGITfmcfnWGLNIDMLTTVI-----HPNRRSTAFSYFVLVSHLFGdASGPYLIGLISDA 406
Cdd:COG2807 301 APGSLPWLW-AVLLGLG-----QGGLFPLALTLIglrarTPAEAAALSGMAQSVGYLLA-ALGPLLVGALHDA 366

MFS_MdfA_MDR_like

cd17320

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...

23-405

1.42e-13

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 72.22 E-value: 1.42e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  23 VDRYTVAgvLTQVQTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLGSSFvpANHFWLF 102
Cdd:cd17320  15 IDMYLPA--LPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCAL--ASSIEQL 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 103 LVLRSFVGIGEASYSNVAPSLISDMFNGQKR----STVFMIFYFAIPVGSGLGfivgsnvATLTGHWQWGIRVSAIAGLI 178
Cdd:cd17320  91 LIARFLQGLGAAAGSVVARAIVRDLYSGAELakifSLLMMILAIAPALAPLLG-------GLLLLFFGWRAIFVFLALLG 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 179 VMIALVLFTYEPERGAADKAMGESKDVvvttnttyLEDLVILLKTPTLvactWGYT-ALVFVSGTLSWWE---PTVIQHl 254
Cdd:cd17320 164 LLLLLLVLLFLPETLPEEKRKPLLSSL--------LRAYKRVLKNRRF----LGYAlALGLSFAGLFAYLaaaPFIYIE- 230

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 255 tawHQGLndtkdlastDKDRVALYFGAITtagglIGVIFGSMLSKWLVAGWGPFRRLQTdraqplvaGGGALLAAPFLLI 334
Cdd:cd17320 231 ---QLGL---------SPAQFGLLFALNA-----IALILGSLLNGRLVRRFGPRRLLRL--------GLLLLLAAALVLL 285

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17539092 335 GMIFGdKSLVLLYIMIFFGITFMCFNWGL-NIDMLTTVIHPNRRSTAFSYFVLVSHLFGdASGPYLIGLISD 405
Cdd:cd17320 286 LAALL-GGLSLWPLVAPLFLIFFGFGLIFpNATSLALEPFPHVAGTASALLGFLQFLIG-ALAGALVGLLPN 355

MFS_SLC17A9_like

cd17380

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...

11-187

6.95e-13

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 69.89 E-value: 6.95e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  11 VTALFVVNLLNYVDRYTVAGVLTQVQTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLG 90
Cdd:cd17380   1 VILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  91 SSFVPANHFWLFLVLRSFVGIGEASYSNVAPSLISDMFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVATLTGhWQWGIR 170
Cdd:cd17380  81 TPLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYG-WPSVFY 159

                       170
                ....*....|....*..
gi 17539092 171 VSAIAGLIVMIALVLFT 187
Cdd:cd17380 160 FFGLLGLLWALVWLIYL 176

2_A_01_02

TIGR00880

Multidrug resistance protein;

47-186

7.37e-13

Multidrug resistance protein;

Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 65.75 E-value: 7.37e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092    47 GLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWlgAVLGSSFVPANHFWLFLVLRSFVGIGEASYSNVAPSLISD 126
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIF--VLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIAD 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092   127 MFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVATLTGhWQWGIRVSAIAGLIVMIALVLF 186
Cdd:TIGR00880  79 IYPPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLG-WRAPFLFLAILALAAFILLAFL 137

MFS_MMR_MDR_like

cd17321

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...

32-187

1.87e-12

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 68.74 E-value: 1.87e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  32 LTQVQTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLGSSFvpANHFWLFLVLRSFVGI 111
Cdd:cd17321  19 LPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL--APSLAFLIAARALQGI 96

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17539092 112 GEASYSNVAPSLISDMFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVATLTGhWQWGIRVSAIAGLIVMIALVLFT 187
Cdd:cd17321  97 GAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFG-WRWIFLINVPIGLVALLLARTFS 171

MFS_MJ1317_like

cd17370

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...

41-184

5.15e-11

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 64.10 E-value: 5.15e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  41 ISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLGssFVPANHFWLFLVLRSFVGIGEASYSNVA 120
Cdd:cd17370 231 LSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLG--FALGSSLWLLLLGFILWGLYMGAQESIE 308

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17539092 121 PSLISDMFNGQKRSTVFMIFYFaipvGSGLGFIVGSNVATL---TGHWQWGIRVSAIAGLIVMIALV 184
Cdd:cd17370 309 RAAVADLVPAELRGTAYGLFNT----VVGIGWLLASLIAGYlwdLISPSAAFLFSAVLALIALLLLL 371

MFS_MT3072_like

cd17475

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...

36-406

1.94e-10

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 62.26 E-value: 1.94e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  36 QTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLGSSFVpaNHFWLFLVLRSFVGIGeas 115
Cdd:cd17475  23 QEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALV--GSYPVLLVLLFLVGAG--- 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 116 YSNVAPS---LISDMFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVATLTGhWQWGIRVSAIAGLIVMIALVLFTYEPER 192
Cdd:cd17475  98 YGSVQPGggrAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYG-WRAAFVVAGLVSILAAVLFWLFYREPPA 176

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 193 GAADKamgESKDVVVTTNTTYLEDLVILLktptlvactwgytaLVFVSGTLSWWEPTVIQHLTAWhqgLNDTKDLASTDk 272
Cdd:cd17475 177 ASAAT---ESASTLLRSLKEVLRNRDVWL--------------IAIAGALLVAPQFALLTFLLLF---LHDHLGLSVVA- 235

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 273 drvALYFGAITTAGGLIGVIFGSMLSKwlvagwgpfRRLQTDRAQPLVAGGGALLAAPFLLIGMIFGDKSLVLLYIMIFF 352
Cdd:cd17475 236 ---AGALLAVAQLGGALGRIGLGRVSD---------RVFGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILL 303

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*
gi 17539092 353 GITfmCFNW-GLNIDMLTTVIHPNRRSTAFSyFVLVSHLFGDASGPYLIGLISDA 406
Cdd:cd17475 304 GLF--AIGWnGLYLTLVAESAGPEQAGTALG-LANTINFIGIAIGPPLFGLLVDA 355

Sugar_tr

pfam00083

Sugar (and other) transporter;

15-186

2.42e-10

Sugar (and other) transporter;

Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 62.29 E-value: 2.42e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092    15 FVVNLLNYVDRYtvaGVLTQVQTYYNISdSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLGSSFV 94
Cdd:pfam00083  21 AFLTLIDFFKNF---GLSKSVSSLAALS-VLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAA 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092    95 P-ANHFWLFLVLRSFVGIGEASYSNVAPSLISDMFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVATLTGHWQWGIRVSA 173
Cdd:pfam00083  97 KgKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGLNKTSNSDGWRIPLGL 176

                         170
                  ....*....|....
gi 17539092   174 IAGL-IVMIALVLF 186
Cdd:pfam00083 177 QLVPaLLLIIGLLF 190

MFS_SV2_like

cd17316

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...

11-185

3.31e-10

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 61.46 E-value: 3.31e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  11 VTALFVVNLLNYVDRYTVAGVLTQVQTYYN--ISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAV 88
Cdd:cd17316   1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSlgLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  89 LGSSFVPAnhFWLFLVLRSFVGIGEASYSNVAPSLISDMFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVATLTGHWqWG 168
Cdd:cd17316  81 LLIGLLPT--PILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGD-WG 157

                       170
                ....*....|....*...
gi 17539092 169 IRVS-AIAGLIVMIALVL 185
Cdd:cd17316 158 WRILfLIGALPALLALLL 175

UhpC

COG2271

Sugar phosphate permease [Carbohydrate transport and metabolism];

9-192

5.16e-10

Sugar phosphate permease [Carbohydrate transport and metabolism];

Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 61.04 E-value: 5.16e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092   9 ISVTALFVVNLLNYVDRYTVAGVL-TQVQTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGA 87
Cdd:COG2271 180 LRFWLLALAYFLVYFALYGFLTWLpTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAA 259

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  88 VLGSSFVPANHFWLFLVLRSFVGIGEASYSNVAPSLISDMFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVATLTGhWQW 167
Cdd:COG2271 260 LALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQA 338

                       170       180
                ....*....|....*....|....*
gi 17539092 168 GIRVSAIAGLIVMIALVLFTYEPER 192
Cdd:COG2271 339 AFLLLAALALLAALLALLLLRETRK 363

MFS_MdtH_MDR_like

cd17329

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...

14-198

6.31e-10

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 60.70 E-value: 6.31e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  14 LFVVNLLNYVDRYTVAGVLT-QVQTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLGss 92
Cdd:cd17329   4 LLIGSFLNRLGFFMVWPFMAiYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFAL-- 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  93 FVPANHFWLFLVLRSFVGIGEASYSNVAPSLISDMFNGQKRSTVFMIFYFAIpvgsGLGFIVGSNVATLTGHWQWGIRVS 172
Cdd:cd17329  82 LGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAI----NLGVAIGPLLGGLLLLYSFRLLFL 157

                       170       180
                ....*....|....*....|....*.
gi 17539092 173 AIAGLIVMIALVLFTYEPERGAADKA 198
Cdd:cd17329 158 AAAVLFLLAALVLLFLLPETRPKRRA 183

MFS_OPA_SLC37

cd17312

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...

22-186

9.83e-10

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 59.98 E-value: 9.83e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  22 YVDRYTVAGVLTQVQTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLGSSFVpaNHFWL 101
Cdd:cd17312  16 YVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFS--TSLWF 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 102 FLVLRSFVGIGEASYSNVAPSLISDMFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVATLTGhWQWGIRVSAIAGLIVMI 181
Cdd:cd17312  94 FAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYG-WRAAFLVPGIVGLVVAI 172


                ....*
gi 17539092 182 ALVLF 186
Cdd:cd17312 173 ILFFF 177

MFS_FsR

cd17478

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...

28-183

1.04e-09

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 59.88 E-value: 1.04e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  28 VAGVLTQVQTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLGSSFVPanHFWLFLVLRS 107
Cdd:cd17478  15 LPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAP--NYWLLLLLVA 92

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17539092 108 FVGIGEASYSNVAPSLISdMFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVATLTGHWQWGIrVSAIAGLIVMIAL 183
Cdd:cd17478  93 LAGIGSAAFHPEGARLAS-QAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLI-LLIIPGLAVALLL 166

MFS_SLC22

cd17317

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...

45-181

1.30e-09

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 59.52 E-value: 1.30e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  45 LGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLGSSFVPanHFWLFLVLRSFVGIGEASYSNVAPSLI 124
Cdd:cd17317  26 LVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSP--SYELFLVLRFLVGVTSAGIFTVGFVLG 103

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 17539092 125 SDMFNGQKRSTVFMIFYFAIPvgsgLGFIVGSNVATLTGHWQWGIRVSAIAGLIVMI 181
Cdd:cd17317 104 MEIVGPKYRSFVGILFGLFWA----LGYMLLALLAYLIRDWRWLQLAISLPGLLFLL 156

MFS_YfcJ_like

cd17489

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...

42-203

1.40e-09

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 59.53 E-value: 1.40e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  42 SDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLGSSFVPAnhFWLFLVLRSFVGIGEASYSNVAP 121
Cdd:cd17489  29 SEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATS--VALLLVLRLIHGIGWGAFTTAAA 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 122 SLISDMFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVATLTGHWqwgiRVSAIAGLIVMIALVLFTYEPERGAADKAMGE 201
Cdd:cd17489 107 TLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFA----VLFIVAAVLALLALLLVFLVKDPPPVAAEEAE 182


                ..
gi 17539092 202 SK 203
Cdd:cd17489 183 AG 184

NarK

COG2223

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];

26-195

1.52e-09

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];

Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 59.51 E-value: 1.52e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  26 YTVAGVLTQV-QTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLGSSFVPANhFWLFLV 104
Cdd:COG2223 222 IGFSSWLPPYlVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGS-LWLFLV 300

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 105 LRSFVGIGEASYSNVAPSLISDMFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVATLTGHWQWGIRVSAIAGLiVMIALV 184
Cdd:COG2223 301 LFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLAL-VALVLT 379

                       170
                ....*....|.
gi 17539092 185 LFTYEPERGAA 195
Cdd:COG2223 380 LLLYRRPRRAA 390

MFS_SLCO_OATP

cd17336

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ...

11-156

3.09e-09

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340894 [Multi-domain] Cd Length: 411 Bit Score: 58.79 E-value: 3.09e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  11 VTALFVVNLLNYVDRYTVAGVLTQVQTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNR-KWIMIIGVGIWLGAVL 89
Cdd:cd17336   5 VVLLCLLGLLQGAVVSYFVSTITTIEKRFGLSSSQSGLILSANDIGQLLAVLLVSYFGGRGHRpRWIGIGSILMGLGCFL 84

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17539092  90 GSsfVPanHFwlFLVLRSFVGIGEASYSNVAPSLISDmFNGQKRSTVFMIFYFAIPV-GSGLGFIVGS 156
Cdd:cd17336  85 LA--LP--HF--LFVGQFLLGIGSSPLYTLGITYIDD-NVSKKNSPLYIGILYAMRVlGPALGFLLGS 145

OATP

pfam03137

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...

30-301

6.13e-09

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.

Pssm-ID: 460821 [Multi-domain] Cd Length: 526 Bit Score: 58.37 E-value: 6.13e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092    30 GVLTQVQTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNR-KWimiIGVGIWLGAVlgSSFV---PanHFwLFLVL 105
Cdd:pfam03137  22 SSITTIEKRFGLPSSLSGLISSSYDIGNLLLIVFVSYFGGKGHRpRW---IGVGALLMGL--GSLLfalP--HF-LSFFL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092   106 RSFV-GIGEASYSNVAPSLISDmfNGQKRSTVFM--IFYFAIPVGSGLGFIVGSNVA-----------TLT-------GH 164
Cdd:pfam03137  94 GQLLlGIGGTPIYTLGISYIDD--NVKKKNSPLYlgILYAVRVLGPALGFLLGSLCLriyvdigkvsiTLTpkdprwvGA 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092   165 WqW-GIRVSAIAGLIVMIALVLFTYEPERGAADKAM-----------GESKDVVVTTNTTYLED----LVILLKTPTLVA 228
Cdd:pfam03137 172 W-WlGFLIAGLLLLLTAIPFFFFPKSLPGAAKRRAKkkkephsqdiaDLKKTKSLKKLGPSLKDfpkaLKRLLKNPVYML 250

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17539092   229 CTWGYTALVFVSGTLSWWEPTVIQ---HLTAWhqglndtkdlastdkdRVALYFGAITTAGGLIGVIFGSMLSKWL 301
Cdd:pfam03137 251 LTLASVFEFLLIAGYATFLPKYIEtqfGLSAS----------------TANLLTGVVAIPGAALGILLGGLIIKKF 310

2A0104

TIGR00881

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...

15-243

1.05e-08

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]

Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 57.00 E-value: 1.05e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092    15 FVVNLLNYVDRYTVAGVLTQVQTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLGSSFv 94
Cdd:TIGR00881   1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGF- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092    95 pANHFWLFLVLRSFVGIGEASYSNVAPSLISDMFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVATLTGHWQWGIRVSAI 174
Cdd:TIGR00881  80 -STSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWVFIVPGI 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17539092   175 AGLIV-MIALVLFTYEPER---GAADKAMGESKDVVVTTNTTYLEDLVILLKTPTLVACTWG-YTALVFVSGTL 243
Cdd:TIGR00881 159 IAIIVsLICFLLLRDSPQScglPPAEEMPNEEPDGDAEKKEEELTKKQIFLQYVLLNKVLWYiSLGYVFVYVVR 232

2A0119

TIGR00898

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]

47-182

1.09e-08

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]

Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 57.33 E-value: 1.09e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092    47 GLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLGSSFVPanHFWLFLVLRSFVGIGEASYSNVAPSLISD 126
Cdd:TIGR00898 130 DLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSP--NYTVFLVFRLLVGMGIGGIWVQAVVLNTE 207

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 17539092   127 mFNGQKRSTVFMIFYFaipVGSGLGFIVGSNVATLTGHWQWGIRVSAIAGLIVMIA 182
Cdd:TIGR00898 208 -FLPKKQRAIVGTLIQ---VFFSLGLVLLPLVAYFIPDWRWLQLAVSLPTFLFFLL 259

MFS_YfcJ_like

cd17489

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...

27-188

3.13e-08

Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 55.29 E-value: 3.13e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  27 TVAGVLTQVQTYYN-ISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLGSSFvpANHFWLFLVL 105
Cdd:cd17489 209 AYGAISTFLPLYAAeRGISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSF--AGSPWMLLLA 286

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 106 RSFVGIGEASYSNVAPSLISDMFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVATLTGHWQwgirVSAIAGLIVMIALVL 185
Cdd:cd17489 287 AVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRA----MFLLAAVVVLLALVL 362


                ...
gi 17539092 186 FTY 188
Cdd:cd17489 363 YIF 365

2A0115

TIGR00895

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...

39-401

4.68e-08

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]

Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 55.06 E-value: 4.68e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092    39 YNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLGSSFvpANHFWLFLVLRSFVGIGEASYSN 118
Cdd:TIGR00895  47 WGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCAL--ATNVTQLLILRFLAGLGLGGLMP 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092   119 VAPSLISDMFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVATLTGhWQWGIRVSAIAGLIVMIALVLFTYEPER------ 192
Cdd:TIGR00895 125 NLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFG-WRSLFYVGGIAPLLLLLLLMRFLPESIDflvskr 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092   193 --------GAADKAMGESKDVVVTT---NTTYLEDLVILLKTPTLVACT---W-GYTALVFVSGTLSWWEPTVIQHLTAw 257
Cdd:TIGR00895 204 petvrrivNAIAPQMQAEAQSALPEqksTQGTKRSVFKALFQGKTARITvllWlLYFMLLVGVYFLTNWLPKLMVELGF- 282

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092   258 hqglndtkdlastdKDRVALYFGAITTAGGLIGVIFGSMLSkwlvagwgpfrrlqtDRAQPLVAGGGALLAAPFLLIGMI 337
Cdd:TIGR00895 283 --------------SLSLAATGGALFNFGGVIGSIIFGWLA---------------DRLGPRVTALLLLLGAVFAVLVGS 333

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17539092   338 FGDKSLVLLYIMIFFGitfMCFNWGLNIDM-LTTVIHPNR-RSTAFSYFVLVSHlFGDASGPYLIG 401
Cdd:TIGR00895 334 TLFSPTLLLLLGAIAG---FFVNGGQSGLYaLMALFYPTAiRATGVGWAIGIGR-LGAIIGPILAG 395

MFS_SLC46_TetA_like

cd17330

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...

40-186

5.61e-08

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 54.51 E-value: 5.61e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  40 NISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVgiwLGAVLGS-SFVPANHFWLFLVLRSFVGIGeASYSN 118
Cdd:cd17330  30 GASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSL---AGSAVSYvLLGLSRNLWLLFLARFLDGLT-GGNVS 105

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17539092 119 VAPSLISDMFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVATLTGHwQWGIRVSAIAGLIVMIALVLF 186
Cdd:cd17330 106 VAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGY-ALPFLVAAALALLNLVLVLFF 172

MFS_MelB_like

cd17332

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...

37-188

8.83e-08

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 54.15 E-value: 8.83e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  37 TYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLGSSFVPANHFWLFLVLRSFVGIGEASY 116
Cdd:cd17332 249 KYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPPGNLVLILVLAVLAGIGYGGA 328

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 117 SNVAPSLISD------MFNGQKRS-TVFMIFYFAIPVGSGL-GFIVG---------SNVATLTGHWQWGIRVSAIAGLIV 179
Cdd:cd17332 329 NLLPWAMLADvidygeLKTGKRREgIFYSVMTFFRKLGLALaGALVGlilslagyvANAAAQSASALNGIRLLIAVLPAV 408


                ....*....
gi 17539092 180 MIALVLFTY 188
Cdd:cd17332 409 LLLLALILM 417

MFS_YcxA_like

cd17355

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...

11-441

1.15e-07

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 53.81 E-value: 1.15e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  11 VTALFVVNLLNYVDRYTVAGVLTQVQTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLG 90
Cdd:cd17355   5 LAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVL 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  91 SSFVPaNHFWLFLVLRSFVGIGEASYSNVAPSLISDMFNGQKRSTVFMIFYFAIPVGSglgFIVGSNVATLTGH--WQWG 168
Cdd:cd17355  85 LALAT-SLWQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGS---LVFLPLGAALIEAfgWRTA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 169 IRVSAIAGLIVMIALVLFtyePERGAADKAmgeSKDVVVTTNTTYLEDLVILLKTPTLVACTWGYTALVFVSGTLswwep 248
Cdd:cd17355 161 LLVLALLALLVLVPVLLL---LRRRPADLA---LRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGL----- 229

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 249 tvIQHLTAW--HQGLNDTkdlastdkdrvalyfgAITTAGGLIGV--IFGSMLSKWLVAGWGPfrrlqtdraqPLVAGGG 324
Cdd:cd17355 230 --IVHLVPYlaDRGISPA----------------AAAVALALIGLfnIVGRLLSGWLGDRYSP----------RRLLAAS 281

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 325 ALLAAPFLLIGMIFGDKSLVLLYIMIFFGitfmcFNWGLNID---MLTTVIHPNRRSTAFSYFVLVSHLFGDASGPYLIG 401
Cdd:cd17355 282 YALRALGLALLLLLPFPPLALLLFAALFG-----LGWGATVPltaALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGG 356

                       410       420       430       440
                ....*....|....*....|....*....|....*....|
gi 17539092 402 LISDAirhgstypkdqYHSLVSATYCCVALLLLSAGLYFV 441
Cdd:cd17355 357 LLYDR-----------TGSYTAAWALAVALGLIAALLVLP 385

MFS_MefA_like

cd06173

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...

42-407

2.28e-07

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 53.00 E-value: 2.28e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  42 SDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLG---SSFVPANHFWLFLVLRSFVGIGEASYSN 118
Cdd:cd06173  32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVlalLALLGSLSLWLLLVLAFLLGIASAFFGP 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 119 VAPSLISDMFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVATLTGHWqWGIRVSAIAGLIVMIALVLFTYEPERGAADKA 198
Cdd:cd06173 112 ARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPG-GAFAINALSFLLSALLLLFIRRPPPAAPGESS 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 199 MGESKDVvvttnttyLEDLVILLKTPTLVACTWGYTALVFVSGTLswWEPTVIQHLTAWHQGlndtkdlastdkdrvALY 278
Cdd:cd06173 191 SLLLRDL--------REGLRYLRRSPLLRLLLLALALFALLGGAL--TVLLPLLAKEVLGGG---------------AAG 245

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 279 FGAITTAGGlIGVIFGSMLSKWLVAGWGPFRrlqtdraqpLVAGGGALLAAPFLLIGMIFgdkSLVLLYI-MIFFGITFM 357
Cdd:cd06173 246 YGLLLAAFG-VGALLGALLLGRLSKRRRRGR---------LLLIGALLLGLALLVLGLSP---SLWLLLAaLFLLGLAGG 312

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|
gi 17539092 358 CFNWGLNIdMLTTVIHPNRRSTAFSYFVLVSHLFGdASGPYLIGLISDAI 407
Cdd:cd06173 313 LFNVPLNT-LLQLRVPDELRGRVFSVYNALNSGAM-PLGALLAGLLADAL 360

MFS_HXT

cd17356

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...

37-186

2.41e-07

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 53.02 E-value: 2.41e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  37 TYYNISDSLGGLIQTVFLISFMVfSPVCGYLGDRFNRKWIMIIGVGIWL-GAVLgsSFVPANHFWLFLVLRSFVGIGEAS 115
Cdd:cd17356  39 TYYPSSSRQGLIVSIVNLGSFFG-ALISSFLSDRIGRKKSIQIGCVIYIiGAII--QVAAIGKWYQLIVGRIIAGLGVGF 115

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17539092 116 YSNVAPSLISDMFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVATLTGHWQWGIRVS--AIAGLIVMIALVLF 186
Cdd:cd17356 116 ASVLVPVYQSEVAPKHIRGTLVSLYQLAITIGILVAYCINYGTHKLDGSAQWRIPLGlqIVWGLLLLIGMFFL 188

MFS_PcaK_like

cd17365

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...

40-184

2.72e-07

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 52.59 E-value: 2.72e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  40 NISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLGSSFvpANHFWLFLVLRSFVGIGEASYSNV 119
Cdd:cd17365  30 GLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAF--AQSVLQLALLRFLTGLGLGAAMPN 107

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17539092 120 APSLISDMFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVATLTGhWQWGIRVSAIAGLIVMIALV 184
Cdd:cd17365 108 AITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFG-WRSVFLLGGVPPLILLPLLR 171

MFS_XylE_like

cd17359

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...

28-183

4.78e-07

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 51.80 E-value: 4.78e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  28 VAGVLTQVQTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLGSSFVPanHFWLFLVLRS 107
Cdd:cd17359  20 INGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSP--NFTIFIIARI 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 108 FVGIGEASYSNVAPSLISDMFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVATLTGH-------WQWGIRVSAIAGLIVM 180
Cdd:cd17359  98 IGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVNYLIANAGGAdwlgaegWRWMLGLEAIPAILFL 177


                ...
gi 17539092 181 IAL 183
Cdd:cd17359 178 LGM 180

MFS_FucP_MFSD4_like

cd17333

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...

34-197

5.94e-07

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 51.55 E-value: 5.94e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  34 QVQTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLGssFVPANHFWLFLVLRSFVGIGE 113
Cdd:cd17333  21 SLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALAL--IFATPSIYLFVVLMFLAGLGA 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 114 ASYSNVAPSLISDMFngQKRSTVFMIF-YFAIPVGSGLGFIVGSNVATLTGHWQWGIRVSAIAGLIVMIALVLFTYEPER 192
Cdd:cd17333  99 GILDTGANTFVGALF--EESSATRLNVlHGFFGLGALIGPLIATSLLTSELSWSWAYLIIGLIYLLLAILILLTLFPELP 176


                ....*
gi 17539092 193 GAADK 197
Cdd:cd17333 177 SARNP 181

MFS_TRI12_like

cd06179

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...

42-192

6.03e-07

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 51.86 E-value: 6.03e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  42 SDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIG--VGIwLGAVLGSSfvpANHFWLFLVLRSFVGIGeASYSNV 119
Cdd:cd06179  30 PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGnlLGV-VGSIVAGT---AKSVNMLIGGQALIGIG-AGTQGL 104

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17539092 120 APSLISDMFNGQKRSTVFMIFYFAIPVGSGLG-FIVGSNVATLTGHWQWGIRVSAIAGLIVMIALVLFTYEPER 192
Cdd:cd06179 105 GAAVASELVPNKYRGLVQGVVNLVASPGSALGpLIAGALVEANAAGWRWIFYINAIFNALALILLFFFYHPPPR 178

MFS_SVOP_like

cd17372

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...

34-192

6.64e-07

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 51.38 E-value: 6.64e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  34 QVQTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLGSSFVPaNHFWlFLVLRSFVGIGE 113
Cdd:cd17372  24 AVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAP-NYMW-LIILRCLVGLGL 101

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17539092 114 ASYSNVApSLISDMFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVATLTGhWQWGIRVSAIAGLIVmiaLVLFTYEPER 192
Cdd:cd17372 102 GGGPQLA-SWYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLG-WRWLLAFSSVPSSLL---LVFYRWTPKT 175

MFS_SVOPL

cd17442

Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ...

48-190

7.09e-07

Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341000 [Multi-domain] Cd Length: 375 Bit Score: 51.35 E-value: 7.09e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  48 LIQTVFLISFMVFSPVCGYLGDRFNRkWIMIIGVGIWlGAV--LGSSFVPAnHFWlFLVLRSFVGIGEASYSN---VAPS 122
Cdd:cd17442  40 LVTTMVFFGYMVFSILLGLLADRYGR-WKILLLSFVW-GAYfsLLTSFAPS-YIW-FVFLRCMVGCGVSGHSQgliIKTE 115

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17539092 123 LISDMFNGQKRStVFMIFYFAipvGSGLGFIVGSNVATLTGhWQWGIRVSAIAGLIVmiaLVLFTYEP 190
Cdd:cd17442 116 FLPTKYRGYMLP-LSQIFWLA---GSLLIIGLASVVIPTLG-WRWLIRFASIPGIIL---IVVFKFIP 175

MFS_Amf1_MDR_like

cd17476

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...

32-187

9.27e-07

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 50.72 E-value: 9.27e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  32 LTQVQTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLGSSFVPAnhFWLFLVLRSFVGI 111
Cdd:cd17476  21 LPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPN--FIFFIICRALQGL 98

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17539092 112 GEASYSNVAPSLISDMFN-GQKRSTVFMIFYFAIPVGSGLGFIVGSNVATlTGHWQWGIRVSAIAGLIVMIALVLFT 187
Cdd:cd17476  99 GPAFLLPNAMALLGRTYPpGPRKNIVFSLFGATAPLGFALGGVFGGLFAQ-LAWWPWIFWFLAILAAIVAVAAIFWT 174

MFS_GLUT_like

cd17315

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...

18-189

1.70e-06

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 49.88 E-value: 1.70e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  18 NLLNYVDRYTVAGVLTQVQTYYNISDS--LGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLGSSFvp 95
Cdd:cd17315   6 GLLFGYDLGVINGALLYIAKDLGFGLStsLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSAL-- 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  96 ANHFWLFLVLRSFVGIGEASYSNVAPSLISDMFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVA-TLTGHWQWGIRVSAI 174
Cdd:cd17315  84 APNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSlSPPGWWRLMFALAAV 163

                       170
                ....*....|....*
gi 17539092 175 AGLIvMIALVLFTYE 189
Cdd:cd17315 164 PALL-QLLLMFFLPE 177

MelB

COG2211

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];

36-407

1.76e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];

Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 50.29 E-value: 1.76e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  36 QTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKW--------IMIIGVGIWLGAV-LGSSFVPANHFWLFLVLR 106
Cdd:COG2211  38 TDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpwilIGAIPLALSFVLLfTAPDLSPTGKLIYALVTY 117

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 107 SFVGIGEASYSNVAPSLISDMF-NGQKRSTVFMIFYFAIPVGSGLGFIVGSN-VATLTGHWQWGIRVSAIAGLIVMIALV 184
Cdd:COG2211 118 LLLGLAYTLVNIPYSALGAELTpDYEERTRLSSWRFAFAGLGGLLASVLPPPlVAAFGGDAALGYRLTALIFAVLGLLAF 197

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 185 LFTYepergaadkAMGESKDVVVTTNTTYLEDLVILLKTPTLVAcTWGYTALVFVSGTLSWwepTVIQHLTAWHqgLNDT 264
Cdd:COG2211 198 LLTF---------FGTKERPVPEEEKVSLKESLKALLKNRPFLL-LLLAYLLFFLALALVA---ALLLYYFKYV--LGLS 262

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 265 KDLAStdkdrvalYFGAITTAGGLIGVIFGSMLSKWlvagWGPfrrlqtdraQPLVAGGGALLAAPFLLIGMIFGDKSLV 344
Cdd:COG2211 263 AALVG--------LLLALYFLAALLGAPLWPRLAKR----FGK---------KKAFIIGLLLAALGLLLLFFLGPGNLWL 321

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 345 LLYIMIFFGITFMCFNwGLNIDMLTTVIHP-------NRRSTAFSYFVLVSHLfGDASGPYLIGLISDAI 407
Cdd:COG2211 322 LLVLAALAGIGLGAIL-VLPWAMLADVVDYdewktgrRREGLYFGIFTFAIKL-GQALAGALAGLLLALF 389

MFS_SV2_like

cd17316

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...

33-181

3.02e-06

Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 49.14 E-value: 3.02e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  33 TQVQTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLGSSFVPANHFWLFLVLRSFVGIG 112
Cdd:cd17316 202 TYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFF 281

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17539092 113 EASYSNVAPSLISDMFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVATLTGHWQ---WGIRVSAIAGLIVMI 181
Cdd:cd17316 282 VGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGvpaLILALLAIVALIVAL 353

MFS_Azr1_MDR_like

cd17502

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...

44-167

4.05e-06

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 48.71 E-value: 4.05e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  44 SLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLGSSFvpANHFWLFLVLRSFVGIGEASYSNVAPSL 123
Cdd:cd17502  30 SLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGL--APNMTMLIVGRAIQGIGGGGLMSLAFII 107

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 17539092 124 ISDMFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVATLTGhWQW 167
Cdd:cd17502 108 IADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLS-WRW 150

MFS_1

pfam07690

Major Facilitator Superfamily;

11-151

8.75e-06

Major Facilitator Superfamily;

Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 47.80 E-value: 8.75e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092    11 VTALFVVNLLNYVDRYTVAGVLTQVQTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLG 90
Cdd:pfam07690 202 VLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALG 281

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17539092    91 SSFVP-ANHFWLFLVLRSFVGIGEASYSNVAPSLISDMFNGQKRSTVFMIFYFAIPVGSGLG 151
Cdd:pfam07690 282 LLLLSlTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343

MFS_SLCO4_OATP4

cd17403

Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of ...

15-186

1.04e-05

Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4 (SLCO4) or Organic anion transporting polypeptide 4 (OATP4) family contains two families: OATP4A and OATP4C, each containing one mammalian member, OATP4A1 and OATP4C1, respectively. OATP4A1 (encoded by SLCO4A1), is ubiquitously expressed and mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4C1 (encoded by SLCO4C1) is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate, cAMP, and uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs). The SLCO4/OATP4 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340961 [Multi-domain] Cd Length: 420 Bit Score: 47.63 E-value: 1.04e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  15 FVVNLLNYVdrytvagVLTQVQTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNR-KWI----MIIGVGiwlgavl 89
Cdd:cd17403  17 MVVNGFVNV-------SITTIEKRFGLTSTQTGLIASSYDIASVLLLLFVSYFGGRGHKpRWLgigaFIMGIG------- 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  90 gsSFVPA-NHFWLFLVLRSFVGIGEASYSNVAPSLIsDMFNGQKRSTVFM-IFYFAIPVGSGLGFIVGS----------- 156
Cdd:cd17403  83 --SLVFAlPHFTVFILAQLLHGAGATPLYTLGVTYL-DENVSTKMSPLYIgIFYAMAILGPAIGYVLGGfllnlytdidq 159

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 17539092 157 --NVATLT-------GHWQWGIRVSAIAGLIVMIALVLF 186
Cdd:cd17403 160 vdSELGLTpddprwvGAWWLGFLISGALALIIAFPLLGF 198

MFS_YcaD_like

cd17477

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...

40-191

2.32e-05

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 46.40 E-value: 2.32e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  40 NISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLGSSFVPanHFWLFLVLRSFVGIGEASYSNV 119
Cdd:cd17477  27 GVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTD--SPWVWFLLRFVMGIGLAGLFVV 104

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17539092 120 APSLISDMFNGQKRSTVFMIFYFAIpvgsGLGFIVGSNVATLTGHWQWGIRVSAIAGLIVMIALVLFTYEPE 191
Cdd:cd17477 105 SESWLNALATNENRGRVLGLYSTVL----GLGFALGPLLLALVGTAGALPFLIAAVLLLLALVPLLLTRRAA 172

PRK08633

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated

48-203

2.48e-05

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated

Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 47.23 E-value: 2.48e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092    48 LIQTVFLISFMVFSPVCGYLGDRFNRKWIMII----GVGIWLGAVLGSSFvpaNHFWLFLVLRSFVGIGEASYS----NV 119
Cdd:PRK08633   51 IVNALFLLPFLLLSSPAGFLADKFSKNRVIRIvklfEVGLTLLIVLAYYL---GWFWLAFAVTFLLGAQSAIYSpakyGI 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092   120 APSLISDMFNGQKRSTVFMIFYFAIPVGSGLG-FIVGSNVATLTGHWQWGIRVSAIAGLIVMIALVLFTYEPERGAADKA 198
Cdd:PRK08633  128 IPELVGKENLSRANGLLEAFTIVAILAGTALFsFLFESVNGNTPSEILGRIAPAGLVLLAVAVLGLIFAYRLPKVPAAAP 207


                  ....*
gi 17539092   199 MGESK 203
Cdd:PRK08633  208 EVFDK 212

MFS_LmrB_MDR_like

cd17503

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...

27-167

3.92e-05

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 45.64 E-value: 3.92e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  27 TVAGV-LTQVQTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLGSSFvpANHFWLFLVL 105
Cdd:cd17503  13 TIVNVaLPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL--APNLASLIIF 90

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17539092 106 RSFVGIGEASYSNVAPSLISDMFNGQKRSTVFMIFYFAIPVGSGLGFIVGsnvATLTGHWQW 167
Cdd:cd17503  91 RILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLG---GWLTDNLSW 149

MFS_MFSD9

cd17390

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...

39-185

3.96e-05

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 45.68 E-value: 3.96e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  39 YNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLG--AVLGSSFVpanhFWLFLVLRSFVGIGEASy 116
Cdd:cd17390  26 LGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALgyVLLGFSTS----LALLFLSRIPLGIFKHT- 100

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 117 SNVAPSLISDMFNGQKRSTVFMIFYFAipvgSGLGFIVGSNVATLTGHWQWGIR-VSAIAGLIVMIALVL 185
Cdd:cd17390 101 QSLCKAYLSDLVSEQERSRVLGRFNAA----SSLGFILGPVVGGHLAETDGGFYyVALLCSAIFILNAGL 166

MFS_MucK

cd17371

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...

31-434

4.57e-05

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 45.76 E-value: 4.57e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  31 VLTQVQTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLGSSFVPAnhFWLFLVLRSFVG 110
Cdd:cd17371  21 VLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQN--YWQLLILRALAG 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 111 IGEASYSNVAPSLISDMFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVAT-LTGHWQW-GIRVSAIAGLIVMIALVLFTY 188
Cdd:cd17371  99 LGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPlLPPEIAWrVLFLLGALPALLVLFIRRFVK 178

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 189 EPERGAADKAMGESKDVVVTTNTTYLEDLVillktPTLVACTWGYTALVFVSGTLSWWEPTViqhltawhqgLNDTKDLA 268
Cdd:cd17371 179 EPPQWQAARAARRHFADRPSLRELFSPPLL-----RTTLLASLLATGALGGYYGITTWLPSY----------LTGERGLS 243

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 269 stdkdrvalyfgAITTAGGLIGVIFGSMLSKWlVAGWgpfrrlQTDR--AQPLVAgGGALLAAPFLLIgMIFGDKSLVLL 346
Cdd:cd17371 244 ------------FEGSAGYLVVTILGGFLGYL-AGGF------LADRigRRNNFA-LFALGSAISILL-YFFLPLSPTLI 302

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 347 YIMIFFGITFMCFNWGLNIDMLTTVIHPNRRSTAFSYFVLVSHLFGdASGPYLIGLISDAIRHGSTYpkdqyhSLVSATY 426
Cdd:cd17371 303 LILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIG-ALFPFLVGFLATSGSLGTAI------AVFAAVY 375


                ....*...
gi 17539092 427 CCVALLLL 434
Cdd:cd17371 376 YIAGLVLA 383

MFS_NRT2_like

cd17341

Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ...

63-198

1.49e-04

Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 44.16 E-value: 1.49e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  63 VCGYLGDRFNRKWIMIIGVGIWLGAVLGSSFVpANHFWLFLVLRSFVGIGEASYSnVAPSLISDMFNGQKRSTVFMIFYF 142
Cdd:cd17341  53 PYGFLCDRFGGRRVFIASLLLLLIPLLALALA-VSSYWGLLVLGFLLGFAGANFA-SGQPWASFWFPKEKIGGAAGGIAG 130

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17539092 143 AIPVGSGL------GFIVGSNVATLTGHWQWGIRVSAIAGLIVMIALVLFTYEPERGAADKA 198
Cdd:cd17341 131 AGNMGVAVsqllapLIAGAIVFDGGFVGWRNAFFVPGILLAIAAVLVLLFGDDLPTGKASAL 192

MFS_DtpA_like

cd17346

Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ...

41-188

2.65e-04

Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 43.33 E-value: 2.65e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  41 ISDSLGGLIQTVFLISFMVFSPVCGYLGDRF--NRKWIMIIGVGIWLGAVLGssFVPANHFWLFLVLRSFVGIGEASYSN 118
Cdd:cd17346  37 FSEADAASIYGAYTALVYLTPIIGGWLADKVlgARRTVFIGGILMALGYLLL--ALSPFSVSMLYLGLALIIVGNGLFKP 114

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17539092 119 VAPSLISDMFNGQ--KRSTVFMIFYFAIPVGSGLG-FIVGsnVATLTGHWQWGIRVSAIaglIVMIALVLFTY 188
Cdd:cd17346 115 NISSLVGKLYDENdpRRDSGFSIFYMGINLGAFLApLLCG--TLGDNYGYHYGFGLAAV---GMLLGLLIFLL 182

TRI12

pfam06609

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...

47-190

2.71e-04

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.

Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 43.50 E-value: 2.71e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092    47 GLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWL-GAVLGSSfvpANHFWLFLVLRSFVGIGeASYSNVAPSLIS 125
Cdd:pfam06609  81 GLFSTLWTMGQAVSILMMGRLTDRFGRRPFVIATHIIGLvGAIVGCT---ANKFNTLLAAMTLLGVA-AGPAGASPLFIG 156

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17539092   126 DMFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVAtLTGHWQWGIRVSAIAGLIVMIALVLFTYEP 190
Cdd:pfam06609 157 ELMSNKTKFLGLLIVSAPTIAMNGAGPYFGQRLA-IQGNWRWIFYIYIIMSAIAVLLIIIWYHPP 220

MFS_SLC45_SUC

cd17313

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...

36-179

2.77e-04

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 43.38 E-value: 2.77e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  36 QTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIwLGAVLGSSFVPANhFWLFLVLRSFVGIGEAS 115
Cdd:cd17313 273 SSHYGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVL-FAVGMALMALVHN-VTVALVLFALGGIGWAT 350

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17539092 116 YSNVAPSLISDMFNGQKRST-------VFMIFYFAIPVGSGLGFIV-GSNVATLTGhwqWGIRVSAIAGLIV 179
Cdd:cd17313 351 ININPYPLVSDYHSESGRGQgtdtgllNLAISLAQILVSLLAGPIIdVKGYGTVFP---VAAVASFLSLVGA 419

MFS_FEN2_like

cd17327

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...

7-186

2.99e-04

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 43.01 E-value: 2.99e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092   7 DYISVTALFVVNLLNYVDRYTVAGVLTQ--------VQTYYNIsdslgglIQTVFLISFMVFSPVCGYLGDRFN-RKWIM 77
Cdd:cd17327   3 DLFILPLLCILYFLQYLDKSNISNAAVMgmkedlklVGNQYNW-------GNTVFYVGYIIFELPGNLLLQRFPpSKWLS 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  78 IIGVGiWLGAVLGSSFVpaNHFWLFLVLRSFVGIGEASYSNVAPSLISDMFNGQKRSTVFMIFYFAIPVGSGLGFIVGS- 156
Cdd:cd17327  76 VFIVL-WGLLTLLTAAV--KNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYg 152

                       170       180       190
                ....*....|....*....|....*....|....*
gi 17539092 157 -----NVATLTGhWQWGIRVSAIAGLIVMIALVLF 186
Cdd:cd17327 153 vfkilGVGGLAG-WRWLFIIEGLITIIIGLVIFFW 186

MFS_OAT

cd17374

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...

42-167

3.05e-04

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 43.05 E-value: 3.05e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  42 SDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIigVGIWLGAVLGSSFVPANHFWLFLVLRSFVGIGEASYSNVAP 121
Cdd:cd17374  33 SQSLKSVAQSIFMAGLLVGALIFGHLSDRFGRKFILL--LSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTL 110

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 17539092 122 SLISDMFNGQKRSTVFMIFYFAipvgSGLGFIVGSNVATLTGHWQW 167
Cdd:cd17374 111 ILGTEWTTPRHRALAITLTSCF----FSIGQMLLAGLAYAIRDWRL 152

MFS_ShiA_like

cd17369

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...

48-185

3.59e-04

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 42.90 E-value: 3.59e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  48 LIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWlgAVLGSSFVPA----NHFWLFLVLRSFVGIGEASYSNVAPSL 123
Cdd:cd17369 268 LAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLA--ALFAFPFFWLldtgSTWLIVLAAVVVLGVLHGMMYGPQAAF 345

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17539092 124 ISDMFNGQKRSTVFMIFY-FAIPVGSGLGFIVGSNVATLTGHWQWGIRVSAIAGLIVMIALVL 185
Cdd:cd17369 346 LAELFPTRVRYTGASLGYqLGAILGGGFAPLIATALVAATGSWWPVALYLAALAVISLVAALF 408

MFS_YcaD_like

cd17477

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...

40-188

4.08e-04

Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 42.55 E-value: 4.08e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  40 NISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLGSSFVPANHFWLFLVLRSFVGIGEASYSnV 119
Cdd:cd17477 219 GLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYT-L 297

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17539092 120 APSLISDMFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVATLTGHwqwgirvsaiAGLIVMIALVLFTY 188
Cdd:cd17477 298 ALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGP----------HGLFLFLAAVALLF 356

2A0121

TIGR00900

H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]

47-407

5.98e-04

H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]

Pssm-ID: 162098 [Multi-domain] Cd Length: 365 Bit Score: 41.92 E-value: 5.98e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092    47 GLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLGSSFVPANHF---WLFLVLRSFVGIGEA----SYSNV 119
Cdd:TIGR00900  37 SLAALAGMLPYVVLSPIAGALADRYDRKKVMIGADLIRAVLVAVLPFVALLGGlniWQVYVLAGILAIAQAfftpAYQAM 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092   120 APSLISDMFNGQKRSTVFMIFYFAIPVGSGLGfivGSNVATLTGHwqWGIRVSAIaGLIVMIALVLFTYEPERGAADkAM 199
Cdd:TIGR00900 117 LPDLVPEEQLTQANSLSQAVRSLFYIVGPGIG---GLMYATLGIK--WAIWVDAV-GFAISALLIVSVRIPELAASE-IQ 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092   200 GESKDVVVTTnttyLEDLVILLKTPTLVACTWGYTALVFV-SGTLSWWEP---TVIQHLTAWHqglndtkdlastdkdrv 275
Cdd:TIGR00900 190 ALSNAVLRDT----REGIKFVLKNPLLRTLLLLALLFNLVfAPAIVALFPyvqSKYLGRGSTH----------------- 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092   276 alyFGAITTAGGLigvifGSMLSKWLVAgwgpfrRLQTDRAQPLVAGGGALLAAPFLLIGMIFGDKSLVLLYIMIFFGIT 355
Cdd:TIGR00900 249 ---YGWVLAAFGL-----GALLGALLLG------LLGRYFKRMALMTGAIFVIGLAILVVGLTPPNFPLFLVLWFAIGVG 314

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 17539092   356 FMCFNwGLNIDMLTTVIHPNRRSTAFSYFVLVSHLFGDASGPyLIGLISDAI 407
Cdd:TIGR00900 315 YGPIN-VPQGTLLQRRVPAELLGRVFGAQFSLSHAAWPLGLI-LAGPLADHL 364

BtlA

COG2270

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...

44-198

6.60e-04

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];

Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 42.06 E-value: 6.60e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  44 SLGGLIQTVFLISF--MVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLGSSFVPAnhFWLFLVLRSFVGIGEASYSNVAP 121
Cdd:COG2270 272 STTELIVFGLLVQIvaALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTT--ALAFWILGLLIGLVMGGIQALSR 349

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 122 SLISDMFNGQKRSTVFMIFYFAIPVGSGLG-FIVGSnVATLTGHWQWGirvsaIAGLIVM--IALVLFTYEPERGAADKA 198
Cdd:COG2270 350 SLLARLIPPGREAEFFGLYALSGKAASFLGpLLFGL-VTQLTGSQRLG-----ILSLIVFfvIGLVLLLRVKVPRGRAAA 423

MFS_NIMT_CynX_like

cd17339

2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ...

27-182

7.26e-04

2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 41.79 E-value: 7.26e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  27 TVAGVLTQVQTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKwiMIIGVGIWLGAVlGSSFVPANHFWLFLVLR 106
Cdd:cd17339  17 SVGPLLPEIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLE--RTLLLALLLLAA-GILLRSLGGIALLFLGT 93

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17539092 107 SFVGIGEASYSNVAPSLISDMFngQKRSTVFMIFY-FAIPVGSGLG-FIVGSNVATLTGHWQWGIRVSAIAGLIVMIA 182
Cdd:cd17339  94 ALAGAGIAVGNVLLPSLIKRDF--PRRVGLMTGLYtTSMNLGAALAsGLSVPLAQALGGGWRGALAIWALPALLALLI 169

MFS_GLUT10_12_Class3_like

cd17362

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...

30-183

8.08e-04

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 41.57 E-value: 8.08e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  30 GVLTQVQT-------YYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLGSSFVPAnhFWLF 102
Cdd:cd17362  18 GALLSITSpalsgtdWYNLSSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPS--YPVL 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 103 LVLRSFVGIGEASYSNVAPSLISDMFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVATLTGHWQWGIRVSAIAGLIVMIA 182
Cdd:cd17362  96 LVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVSLKELFIVLGILLGYVSGYAFADVVGGWRYMYGLAAPPALLLGIG 175


                .
gi 17539092 183 L 183
Cdd:cd17362 176 M 176

MFS_2

pfam13347

MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...

37-188

8.57e-04

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.

Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 41.53 E-value: 8.57e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092    37 TYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLGSSFVPANHFWLFLVLRSFVGIGEASY 116
Cdd:pfam13347 252 RYVLGNGFAASAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILGALITIAGFALALLLGPNNTLLFLVLYIIIGFGYGSS 331

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092   117 SNVAPSLISDMF------NGQKRSTVFM-IFYFAIPVGSGLGFIVGSNVATLTG----------HWQWGIRVSA---IAG 176
Cdd:pfam13347 332 FFLPWSMLADVVdygelrTGKRREGTFFaMWSFISKLATGVGLGVSGLLLSAFGynagdsvqspQAVTAIRLLYavlPAV 411

                         170
                  ....*....|..
gi 17539092   177 LIVMIALVLFTY 188
Cdd:pfam13347 412 LFLVALLLLYFY 423

MFS_FsR

cd17478

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...

37-105

8.79e-04

Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 41.39 E-value: 8.79e-04

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17539092  37 TYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIgvGIWLGAVLGSSFVPANHFWLFLVL 105
Cdd:cd17478 223 VQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIA--SLLLAAPFLLLFLLTPGIWSYILL 289

synapt_SV2

TIGR01299

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...

23-114

1.49e-03

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.

Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 41.12 E-value: 1.49e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092    23 VDRYTVAGVLTQVQTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLGSSFVPANHFWLF 102
Cdd:TIGR01299 181 VEVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFLF 260

                          90
                  ....*....|..
gi 17539092   103 LVLRSFVGIGEA 114
Cdd:TIGR01299 261 CRLLSGFGIGGA 272

MFS_MMR_MDR_like

cd17321

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...

12-116

1.58e-03

Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 40.62 E-value: 1.58e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  12 TALFVVNLLNYVDRYTVAGVLTQV-QTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLG 90
Cdd:cd17321 171 SGAVLAAFLLGAALGGLLFLLPLYlQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLL 250

                        90       100
                ....*....|....*....|....*..
gi 17539092  91 SSFVPANHFWLFLVLRSFV-GIGEASY 116
Cdd:cd17321 251 LALLGADSSVWLLLPGLVLlGLGLGLF 277

MFS_SLCO5_OATP5

cd17404

Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of ...

29-186

1.66e-03

Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 5 (SLCO5) or Organic anion transporting polypeptide 5 (OATP5) family contains only one subfamily, OATP5A, which contains only one mammalian member OATP5A1 (encoded by SLCO5A1). Deletion of the SLCO5A1 gene has been implicated in the pathogenesis of Mesomelia-synostoses syndrome (MSS), a rare autosomal-dominant disorder characterized by mesomelic limb shortening, acral synostoses, and multiple congenital malformations. OATP5A1 may be a non-classical OATP which is involved in biological processes that require the reorganization of the cell shape, such as differentiation and migration. It seems to affect intracellular transport of drugs and may participate in chemoresistance of small cell lung cancer (SCLC by sequestration), rather than mediating cellular uptake. The SLCO5/OATP5 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340962 [Multi-domain] Cd Length: 425 Bit Score: 40.80 E-value: 1.66e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  29 AGVLTQVQTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNR-KWIMIIGVGIWLGAVLGSsfVPanHFwlFLVLRS 107
Cdd:cd17404  23 NSVITTIEKRYSLKSSESGLIVSSYEIGSLLTVVFVSYFGGRGHRpRWIAVGGVLIALGSFLFS--LP--HF--FILAQI 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 108 FVGIGEASYSNVAPSLISDMFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVATL------------------TGHWQWGI 169
Cdd:cd17404  97 LIGMGGTPIFTLGTTYLDDHVKKESSSLYLAIMYVMGALGPAAGFLLGGLLINFyvdplstppdispgdprwIGAWWGGF 176

                       170
                ....*....|....*..
gi 17539092 170 RVSAIAGLIVMIALVLF 186
Cdd:cd17404 177 LLCGIALLLVAFPFFTF 193

MFS_SLC22A1_2_3

cd17379

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...

48-167

1.95e-03

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 40.41 E-value: 1.95e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  48 LIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLGSSFVPanHFWLFLVLRSFVGIGEASYSNVAPSLISDM 127
Cdd:cd17379  37 LFQSSLNLGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSP--NYPWFLIFRFLQGLFGKGGWMTGYVLVTEF 114

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 17539092 128 FNGQKRSTVFMIFYFAIPVgsglGFIVGSNVATLTGHWQW 167
Cdd:cd17379 115 VGSKYRRTVGIVYQMFFTL----GLLILPGIAYFIPHWRW 150

MFS_YajR_like

cd17472

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...

47-192

2.01e-03

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 40.28 E-value: 2.01e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  47 GLIQTVFLISFmvfspvcGYLGDRFNRKWIMIIGVGIWLGAVLGSSFvpANHFWLFLVLRSFVGIGeaSYSNVAPSLISD 126
Cdd:cd17472  42 GLTQAIFQIPF-------GLLSDRIGRKPVILFGLLLFIAGSLLAAY--ATSIYGLILGRALQGSG--AISSVVMALLAD 110

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092 127 MFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVATLtghwqWGIRV----SAIAGLIVMIALVLFTYEPER 192
Cdd:cd17472 111 LTREENRTKAMALIGASIGIAFAISMVLGPLLAAH-----LGVSGlfliTAILSLVSLLILLFFVPDPPK 175

MFS_SLC22A4_5_OCTN1_2

cd17376

Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ...

42-178

2.84e-03

Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340934 [Multi-domain] Cd Length: 342 Bit Score: 39.76 E-value: 2.84e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  42 SDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLGSSFVPAnhFWLFLVLRSFVGIGEASYSNVAP 121
Cdd:cd17376  33 DDWKVPLTTSLFFVGVLLGSFISGQLSDRFGRKKVLFATMAVQTGFSFLQIFSPS--WEMFTVLFVIVGMGQISNYVVAF 110

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 17539092 122 SLISDMFNGQKRstvfMIF-YFAIPVGSGLGFIVGSNVATLTGHWQWGIRVSAIAGLI 178
Cdd:cd17376 111 VLGTEILGKSVR----ILFsTLGVCIFYAIGYMLLPLFAYFIRDWRMLLLALTLPGVL 164

MFS_SV2B

cd17438

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...

23-114

2.99e-03

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 39.91 E-value: 2.99e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  23 VDRYTVAGVLTQVQTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLGSSFVPANHFWLF 102
Cdd:cd17438  13 VEVFVVGFVLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAFLF 92

                        90
                ....*....|..
gi 17539092 103 LVLRSFVGIGEA 114
Cdd:cd17438  93 CRLISGFGIGGS 104

MFS_MCT_SLC16

cd17352

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...

41-155

3.26e-03

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 39.84 E-value: 3.26e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  41 ISDSLGGLIQTVFLISFMVFSPVCGYLGDR--FNRKWIMIIGVGIwLGAVLGSSFVpANHFWLFLVLRSFVGIGEASYSN 118
Cdd:cd17352 215 IDESDAAFLLSIIGISDIVGRILLGLLADKprIGRLYLYIFTLLI-LGLSLLAFPL-ATTYVGLIVFSVLFGFCSGSYSS 292

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 17539092 119 VAPSLISDMFNGQKRSTVFMIFYFAipvgSGLGFIVG 155
Cdd:cd17352 293 LTPVILADLVGLEKLSNAYGLVLLF----QGLAALVG 325

PRK03893

putative sialic acid transporter; Provisional

19-245

4.19e-03

putative sialic acid transporter; Provisional

Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 39.68 E-value: 4.19e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092   19 LLNYVDRYTVAGVLTQVQTYYNIsdslgGLIQTVFLISFMVFSP-----VCGYLGDRFNRKWIMIIGVGIWLGAVLGSSF 93
Cdd:PRK03893  30 LLDGFDFVLITLVLTEVQGEFGL-----TTVQAASLISAAFISRwfgglLLGAMGDRYGRRLAMVISIVLFSVGTLACGF 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092   94 VPAnhFWLFLVLRSFVGIGEA-SYSNVAPSLI-SDMFNGQKRSTVFMIFYFAIpvGSGLGFIVGSNVATLtghwqWGIRV 171
Cdd:PRK03893 105 APG--YWTLFIARLVIGMGMAgEYGSSATYVIeSWPKHLRNKASGFLISGFSI--GAVVAAQVYSLVVPV-----WGWRA 175

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17539092  172 SAIAGLI-VMIALVLFTYEPERGAADKAMGESKDVVVTTNTTYLEDLVIL--LKTPTLVACTWGYTALVFVSGTLSW 245
Cdd:PRK03893 176 LFFIGILpIIFALWLRKNLPEAEDWKEKHAGKAPVRTMVDILYRGEHRIIniLLTLAAAAALWFCFAGNLQNAAIVA 252

MFS_SLC49

cd17334

Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ...

11-192

4.72e-03

Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340892 [Multi-domain] Cd Length: 407 Bit Score: 39.31 E-value: 4.72e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  11 VTALF-VVNLLNYVDRYTVAGVLTQVQTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGI-WLGAV 88
Cdd:cd17334   5 VLLLFsLLSFSNAMQWITFSPIADEARTFFDLSASQINWLSLVYPIVYVPGVFAFCWLLDKVGLRIGVLIGAALnALGSV 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  89 LG-SSFVPANHFWLFLVLRSFVGIGEASYSNVAPSLISDMFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVATLTGHW-- 165
Cdd:cd17334  85 LKcIPLGQQPKFALLVLGQVLNALAQVLVLSLPPLIAAVWFPPKERTTATAIASLANFLGCAIGFLLPPVVVPPPKGTkk 164

                       170       180
                ....*....|....*....|....*..
gi 17539092 166 QWGIRVSAIAGLIVMIALVLFTYEPER 192
Cdd:cd17334 165 EFGAVFYGEFGFACLLLALVLALFPPK 191

MFS_SV2

cd17363

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...

23-114

4.89e-03

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 39.39 E-value: 4.89e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  23 VDRYTVAGVLTQVQTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNRKWIMIIGVGIWLGAVLGSSFVPANHFWLF 102
Cdd:cd17363  13 VEVFVVGFVLPSAEKDMCLSNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQGYGFFLF 92

                        90
                ....*....|..
gi 17539092 103 LVLRSFVGIGEA 114
Cdd:cd17363  93 CRLLSGIGIGGS 104

MFS_YxlH_like

cd17490

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...

40-194

5.40e-03

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 39.13 E-value: 5.40e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  40 NISDSLGGLIQTVFLISFMVFSPVCGYLGDRFN-RKWIMIIGVGIwlgAVLGSSFVP-ANHFWLFLVLRSFVGIGEASYS 117
Cdd:cd17490  27 GASLSMIGIILGAYGISQMLLRIPLGILSDRIGkRKLFIIIGLLF---TVLASLIMIlFPSPWGLLIARFLSGIAAATWV 103

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17539092 118 nVAPSLISDMFNGQKRSTVFMIFYFAIPVGSGLGFIVGSNVATLTGhWQWGIRVSAIAGLIVMIaLVLFTYEPERGA 194
Cdd:cd17490 104 -SFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFG-MRAPFLLAALAGVLGFI-LSLFIKEERREK 177

MFS_SLCO4C_OATP4C

cd17463

Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of ...

14-155

7.25e-03

Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4C (SLCO4C), also called Organic anion-transporting polypeptide 4C (OATP4C), subfamily has one mammalian member, OATP4C1 (encoded by SLCO4C1). It is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. It is the only OATP expressed at the basolateral side of proximal tubular cells in human kidney and it mediates the excretion of uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs) and cause further progression of renal damage and cardiovascular diseases. Overexpression of human SLCO4C1 in rat kidney promotes the renal excretion of uremic toxins and reduces hypertension, cardiomegaly, and renal inflammation in renal failure. The SLCO4C/OATP4C subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341021 [Multi-domain] Cd Length: 429 Bit Score: 38.57 E-value: 7.25e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539092  14 LFVVNLLNYVDRYTVAG----VLTQVQTYYNISDSLGGLIQTVFLISFMVFSPVCGYLGDRFNR-KWIMIIGVGIWLGAV 88
Cdd:cd17463   5 LLFYSLLAVVQGIVVNGlvniSISTIEKRYELSSSLTGLISSSYDISFCLLSLFVSFYGERGHKpRWLAFSAFMIGLGSL 84

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17539092  89 LGSsfVPanHFWLFLVLRSFVGIGEASYSNVAPSLISDMFNGQKRSTVFMIFYFAIPVGSGLGFIVG 155
Cdd:cd17463  85 VFS--LP--HFFVFILGQLLLGVGGTPLYTLGTAYIDDSVPTHKSSLYIGIGYGMSVLGPAIGYLLG 147

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01