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Conserved domains on  [gi|392901224|ref|NP_502400|]
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Importin subunit alpha [Caenorhabditis elegans]

Protein Classification

armadillo/beta-catenin-like repeat-containing protein( domain architecture ID 1000979)

armadillo/beta-catenin-like repeat-containing protein similar to Saccharomyces cerevisiae vacuolar protein 8 that functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SRP1 super family cl34886
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
87-397 3.20e-21

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5064:

Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 96.50  E-value: 3.20e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392901224  87 EVNAVWIITNMCCISQEVTHLFVNSNCLDILIKLVRSQNARLSSQTVWAIANIAADCSSCK---LKCRSpkLLKILarNL 163
Cdd:COG5064  132 QFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSSTEDDVREQAVWALGNIAGDSEGCRdyvLQCGA--LEPLL--GL 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392901224 164 QTSYKLDDADRRQLIWCVNNIfSGGRTTMPS-PVARSLICALSAIL--LDTDAVDNMgcgsmiLWTLANLVDNSLDttRI 240
Cdd:COG5064  208 LLSSAIHISMLRNATWTLSNL-CRGKNPPPDwSNISQALPILAKLIysRDPEVLVDA------CWAISYLSDGPNE--KI 278

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392901224 241 DMLLSQNyVVEHILEKFidqTDKSCNVS--CLRLIGNIAVGNDVQTDLLVDN---PKFRVVmniaMSSPEHH--SEAAWI 313
Cdd:COG5064  279 QAVLDVG-IPGRLVELL---SHESAKIQtpALRSVGNIVTGSDDQTQVIINCgalKAFRSL----LSSPKENirKEACWT 350

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392901224 314 ISNVVAGAPRHVDYIMDDPDAfyEWVMAGIHTGDKRLRKECLWIIGNLLATADEH--QTYLLVSLGIVQHFPALLDFDDV 391
Cdd:COG5064  351 ISNITAGNTEQIQAVIDANLI--PPLIHLLSSAEYKIKKEACWAISNATSGGLNRpdIIRYLVSQGFIKPLCDLLDVVDN 428


                 ....*.
gi 392901224 392 RLNEKA 397
Cdd:COG5064  429 KIIEVA 434
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
87-397 3.20e-21

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 96.50  E-value: 3.20e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392901224  87 EVNAVWIITNMCCISQEVTHLFVNSNCLDILIKLVRSQNARLSSQTVWAIANIAADCSSCK---LKCRSpkLLKILarNL 163
Cdd:COG5064  132 QFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSSTEDDVREQAVWALGNIAGDSEGCRdyvLQCGA--LEPLL--GL 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392901224 164 QTSYKLDDADRRQLIWCVNNIfSGGRTTMPS-PVARSLICALSAIL--LDTDAVDNMgcgsmiLWTLANLVDNSLDttRI 240
Cdd:COG5064  208 LLSSAIHISMLRNATWTLSNL-CRGKNPPPDwSNISQALPILAKLIysRDPEVLVDA------CWAISYLSDGPNE--KI 278

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392901224 241 DMLLSQNyVVEHILEKFidqTDKSCNVS--CLRLIGNIAVGNDVQTDLLVDN---PKFRVVmniaMSSPEHH--SEAAWI 313
Cdd:COG5064  279 QAVLDVG-IPGRLVELL---SHESAKIQtpALRSVGNIVTGSDDQTQVIINCgalKAFRSL----LSSPKENirKEACWT 350

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392901224 314 ISNVVAGAPRHVDYIMDDPDAfyEWVMAGIHTGDKRLRKECLWIIGNLLATADEH--QTYLLVSLGIVQHFPALLDFDDV 391
Cdd:COG5064  351 ISNITAGNTEQIQAVIDANLI--PPLIHLLSSAEYKIKKEACWAISNATSGGLNRpdIIRYLVSQGFIKPLCDLLDVVDN 428


                 ....*.
gi 392901224 392 RLNEKA 397
Cdd:COG5064  429 KIIEVA 434
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 101-141 1.53e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 38.97  E-value: 1.53e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 392901224  101 SQEVTHLFVNSNCLDILIKLVRSQNARLSSQTVWAIANIAA 141
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 101-141 3.19e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 38.18  E-value: 3.19e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 392901224   101 SQEVTHLFVNSNCLDILIKLVRSQNARLSSQTVWAIANIAA 141
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
87-397 3.20e-21

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 96.50  E-value: 3.20e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392901224  87 EVNAVWIITNMCCISQEVTHLFVNSNCLDILIKLVRSQNARLSSQTVWAIANIAADCSSCK---LKCRSpkLLKILarNL 163
Cdd:COG5064  132 QFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSSTEDDVREQAVWALGNIAGDSEGCRdyvLQCGA--LEPLL--GL 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392901224 164 QTSYKLDDADRRQLIWCVNNIfSGGRTTMPS-PVARSLICALSAIL--LDTDAVDNMgcgsmiLWTLANLVDNSLDttRI 240
Cdd:COG5064  208 LLSSAIHISMLRNATWTLSNL-CRGKNPPPDwSNISQALPILAKLIysRDPEVLVDA------CWAISYLSDGPNE--KI 278

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392901224 241 DMLLSQNyVVEHILEKFidqTDKSCNVS--CLRLIGNIAVGNDVQTDLLVDN---PKFRVVmniaMSSPEHH--SEAAWI 313
Cdd:COG5064  279 QAVLDVG-IPGRLVELL---SHESAKIQtpALRSVGNIVTGSDDQTQVIINCgalKAFRSL----LSSPKENirKEACWT 350

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392901224 314 ISNVVAGAPRHVDYIMDDPDAfyEWVMAGIHTGDKRLRKECLWIIGNLLATADEH--QTYLLVSLGIVQHFPALLDFDDV 391
Cdd:COG5064  351 ISNITAGNTEQIQAVIDANLI--PPLIHLLSSAEYKIKKEACWAISNATSGGLNRpdIIRYLVSQGFIKPLCDLLDVVDN 428


                 ....*.
gi 392901224 392 RLNEKA 397
Cdd:COG5064  429 KIIEVA 434
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 101-141 1.53e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 38.97  E-value: 1.53e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 392901224  101 SQEVTHLFVNSNCLDILIKLVRSQNARLSSQTVWAIANIAA 141
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 101-141 3.19e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 38.18  E-value: 3.19e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 392901224   101 SQEVTHLFVNSNCLDILIKLVRSQNARLSSQTVWAIANIAA 141
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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