|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MFSD7 |
cd17399 |
Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily ... |
83-498 |
0e+00 |
|
Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily domain-containing protein 7 (MFSD7) is also called myosin light polypeptide 5 regulatory protein (MYL5). It's function is unknown. It is encoded by the a SLC49A3 gene and is a member of the Solute carrier 49 (SLC49) family, which also includes feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1), FLVCR2 (SLC49A2), as well as disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. MFSD7 belongs to the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340957 Cd Length: 419 Bit Score: 516.05 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 83 SRWFLLVSVALLNFSNTCSWIAYAPVGNYVNALY--GEESAAWFSMIYMFVSVPFGFIGMYIGSKNTLNVPLIAACVLNA 160
Cdd:cd17399 1 RRWFVLLVVCLLNCSNAMIWISFAPVADYTAEYYnvSLDAVNWLSLIYMIVSIPVGFVAMWLLDTLGLRTAIILGAWLNF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 161 IGALIRALSTQPQVDPQNRFPICLLGQSIAAMAYPFIMFLPSKISATCFPPSQRTIATTIGVMANPLGVMVVNLVAPLIV 240
Cdd:cd17399 81 IGAVIRVISSLPFVDPSFRFPVLMTGQTLAAFAQPFILFLPTKLAALWFPDNQRAIANMLASMSNPLGVLLANLLSPLIV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 241 QSSDDVWILNVILFIICFVALFFAGCSLGCLKPDETKQRKSNDYA----TSCGSVFGNLNYDILMFALGGGIGMFNSLYT 316
Cdd:cd17399 161 KSSEDIFLLLSIYTIPALIAVVLATFGVRSSVPPTPPSASAAHESepffVGLKQLFKNKQYLILMLCFGGGIGLFNALST 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 317 MMLQMLCPSGYGNQVAGICAVLMIGCGMIGATVASIYVDKHKNYRTAMIVLMNFAVIFGVGFLWMSKVPNMSLILFFISG 396
Cdd:cd17399 241 LLEQILCPSGYSNNFAGICGALMIGVGLIGAFVAGLIVDKTKKFIEVTKVCFCLAVIFLVAFLVVSRFPNQSVLLAVLCG 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 397 AFGFCGLAAYPVGLELAIECTYPAAPEVSSGFIVLVGQLFSVLIVAIIKIGAKSLSFVDSDFGveaCRAHAEDAINVPKN 476
Cdd:cd17399 321 LFGFFGFAIYPVGLELAVECTYPVAEATSTGLIFMSGQIQGIILVFIMQALATPLSVYDLPIQ---CASSASGNITPLDW 397
|
410 420
....*....|....*....|..
gi 17539122 477 YDNPIIIITFIAVLIAIVVWFL 498
Cdd:cd17399 398 TVPLLVMAGLAAVLAIIFVVFF 419
|
|
| MFS_SLC49 |
cd17334 |
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ... |
84-443 |
5.16e-56 |
|
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340892 [Multi-domain] Cd Length: 407 Bit Score: 193.39 E-value: 5.16e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 84 RWFLLVSVALLNFSNTCSWIAYAPVGNYVNALYG--EESAAWFSMIYMFVSVPFGFIGMYIGSKNTLNVPLIAACVLNAI 161
Cdd:cd17334 2 RWVVLLLFSLLSFSNAMQWITFSPIADEARTFFDlsASQINWLSLVYPIVYVPGVFAFCWLLDKVGLRIGVLIGAALNAL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 162 GALIRALStqpqVDPQNRFPICLLGQSIAAMAYPFIMFLPSKISATCFPPSQRTIATTIGVMANPLGVMVVNLVAPLIVQ 241
Cdd:cd17334 82 GSVLKCIP----LGQQPKFALLVLGQVLNALAQVLVLSLPPLIAAVWFPPKERTTATAIASLANFLGCAIGFLLPPVVVP 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 242 SSDDVW--ILNVILFIICFVALFFAGCSLgcLKPDETKQRKSN-------------DYATSCGSVFGNLNYDILMFALGG 306
Cdd:cd17334 158 PPKGTKkeFGAVFYGEFGFACLLLALVLA--LFPPKPKYPPSAasarqqnsehvilELQKSISELLRNEPFVLLAVAFSI 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 307 GIGMFNSLYTMMLQMLCPSGYGNQVAGICAVLMIGCGMIGATVASIYVDKHKNYRTamIVLMNFAvIFGVGFLWMSKV-- 384
Cdd:cd17334 236 MMGVFAGFSSVLAQILLPFGVSQTSAGWLGFFGIVAGMVGGLLLGLFVDRTRMFKL--IGLIILA-LGTVVCTFFMLLvd 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17539122 385 ----PNMSLILFFISGAFGFCGLAAYPVGLELAIECTYPAAPEVSSGFIVLVGQLFSVLIVAI 443
Cdd:cd17334 313 ryglPYVTLAFYLLCGLLGFFQNSMVPIMFELAVELTYPVPESVSTGVLTALANLFSFLLMLV 375
|
|
| MFS_FLVCR_like |
cd17398 |
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of ... |
84-444 |
2.68e-51 |
|
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of transporters; The Feline leukemia virus subgroup C receptor (FLVCR) subfamily is conserved in metazoans and is composed of two vertebrate members, FLVCR1 and FLVCR2. FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. FLVCR2 functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The FLVCR subfamily belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340956 [Multi-domain] Cd Length: 406 Bit Score: 180.51 E-value: 2.68e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 84 RWFLLVSVALLNFSNTCSWIAYAPVGNYVNALYGEESAA--WFSMIYMFVSVPFGFIGMYIGSKNTLNVPLIAACVLNAI 161
Cdd:cd17398 2 RWIMLFLFCLYSMSNAFQWIQYAIISNIIVDYYGVSDTAvdWTSMIYMLTYIPLIFPATWLLEKYGLRVTVLLGSFLNCL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 162 GALIRALSTQPqvdpqNRFPICLLGQSIAAMAYPFIMFLPSKISATCFPPSQRTIATTIGVMANPLGVMVVNLVAPLIVQ 241
Cdd:cd17398 82 GAWLKLFSSSP-----DLFWVAMAGQTICALAQVFILGIPPRLAAVWFGPDEVSTATAIGVFGNQLGVALGFVLPPLLVP 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 242 SSDD--------------VWILNVILFIIcfVALFFAGC-----SLGCLKPDETKQRKsNDYATSCGSVFGNLNYDILMF 302
Cdd:cd17398 157 NSENkdeigkglsilfygVAGICTALFIL--VIIFFKEKppippSRAQAAAQELRSED-QSYLGSLKRLFKNKGFLLLLI 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 303 ALGGGIGMFNSLYTMMLQMLCPS-GYGNQVAGICAVLMIGCGMIGATVASIYVDKHKNYRTAMIVLMNFAVIFGVGFLWM 381
Cdd:cd17398 234 TYGINTGVYYAISTLLNQMVLEYfPNEEVNAGWIGLTLVIAGLVGSVVAGIWLDKTKKYKETTIIVYILSFIGMVAFTFT 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17539122 382 SKVPNMsLILFFISGAFGFCGLAAYPVGLELAIECTYPAAPEVSSGFIVLVGQLFSVLIVAII 444
Cdd:cd17398 314 LDLGSI-WVVFLTAGALGFFMTGYLPVGFEFAAELTYPEPEGTSSGLLNASAQIFGIIFTLVM 375
|
|
| MFS_FLVCR2 |
cd17456 |
Feline leukemia virus subgroup C receptor-related protein 2 of the Major Facilitator ... |
84-439 |
3.66e-41 |
|
Feline leukemia virus subgroup C receptor-related protein 2 of the Major Facilitator Superfamily of transporters; Feline leukemia virus subgroup C receptor-related protein 2 (FLVCR2) is also called calcium-chelate transporter (CCT). It functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. Mutations in the FLVCR2 gene cause Proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (PVHH), also known as Fowler syndrome, a rare autosomal recessive disorder characterized by glomerular vasculopathy in the central nervous system, severe hydrocephaly, hypokinesia and arthrogryphosis. FLVCR2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341014 Cd Length: 406 Bit Score: 153.01 E-value: 3.66e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 84 RWFLLVSVALLNFSNTCSWIAYAPVGNYVNALYGEESAA--WFSMIYMFVSVPFGFIGMYIGSKNTLNVPLIAACVLNAI 161
Cdd:cd17456 2 RWVIVLLFSSYSLCNAFQWIQYGIINNIFMHFYGVSSFAidWLSMSYMLTYIPLIFPVAWLLDKRGLRVIALVGSALNCL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 162 GALIRALSTQPQVdpqnrFPICLLGQSIAAMAYPFIMFLPSKISATCFPPSQRTIATTIGVMANPLGVMVVNLVAPLIVQ 241
Cdd:cd17456 82 GAWIKTGSARPDL-----FPVTVLGQLVCSVAQVFILGMPSRIASVWFGSSEVSTACSIGVFGNQLGVAIGFLLPPVLVP 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 242 SSDDV----WILNVILFIICFVA--LFFAGCSLGCLKPDETKQR----------KSNDYATSCGSVFGNLNYDILMFALG 305
Cdd:cd17456 157 NIDDLdelaYHISIMFYGTAAVAtlLFILVIIVFQEKPKIPPSQaqaaiqsipsQDYSYLQSILRLLKNVNFILLVVSYG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 306 GGIGMFNSLYTMMLQMLCPSGYGNQV-AGICAVLMIGCGMIGATVASIYVDKHKNYR-TAMIV-------LMNFAVIFGV 376
Cdd:cd17456 237 LNTGCFYALSTLLNRMVIFHYPGEEVnAGRIGLTIVVAGMVGALISGIWLDRTKTYKqTTLAVyimslvgMVVYTFTLNL 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17539122 377 GFLWmskvpnmslILFFISGAFGFCGLAAYPVGLELAIECTYPAAPEVSSGFIVLVGQLFSVL 439
Cdd:cd17456 317 GHLW---------VVFITAGTLGFFMTGYLPLGFEFAAELTYPESEGTSSGLLNVSAQVFGII 370
|
|
| MFS_FLVCR1 |
cd17455 |
Feline leukemia virus subgroup C receptor-related protein 1 of the Major Facilitator ... |
83-443 |
2.13e-34 |
|
Feline leukemia virus subgroup C receptor-related protein 1 of the Major Facilitator Superfamily of transporters; Feline leukemia virus subgroup C receptor-related protein 1 (FLVCR1) is also called feline leukemia virus subgroup C receptor (FLVCR). FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. Mutations in the FLVCR1 gene have been linked to vision impairment, posterior column ataxia, and sensory neurodegeneration with loss of pain perception. FLVCR1 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341013 Cd Length: 407 Bit Score: 134.19 E-value: 2.13e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 83 SRWFLLVSVALLNFSNTCSWIAYAPVGNYVNALYGEESAA--WFSMIYMFVSVPFGFIGMYIGSKNTLNVPLIAACVLNA 160
Cdd:cd17455 1 RRFAVLAVFSLYSLVNAFQWIQYSIITNIFTEFYGVSSGAidWLSVVYMVAYVPLIFPATWLLDLKGLRVTALLGAGLNC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 161 IGALIRALSTQPqvdpqNRFPICLLGQSIAAMAYPFIMFLPSKISATCFPPSQRTIATTIGVMANPLGVMVVNLVAPLIV 240
Cdd:cd17455 81 LGAWVKCASVRP-----DLFGVTMLAQVLCSVAQVFILGLPSRIASVWFGPREVSTACAVAVLGNQLGTAIGFLLPPVLV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 241 -QSSDDVWIL----NVILFIICFVA--LFFAGCSLGCLKPD----------ETKQRKSNDYATSCGSVFGNLNYDILMFA 303
Cdd:cd17455 156 pNTVDDIDLMghniSIMFYGTAAVStlLFILTIIVFKEKPPlppsqaqavlQGIPSEDYSYKQSIINLFKNVPFVLLLIS 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 304 LGGGIGMFNSLYTMMLQMLCPSGYGNQV-AGICAVLMIGCGMIGATVASIYVDKHKNYRTAMIVLMNFAVIFGVGFLWMS 382
Cdd:cd17455 236 YGIMTGTFYSVSTLLNQMIITHYEGEEVnAGRIGLTLVVAGMVGSILCGLWLDYTKTYKQTTLIVYILSFIGMVVFTFTL 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17539122 383 KVPNMsLILFFISGAFGFCGLAAYPVGLELAIECTYPAAPEVSSGFIVLVGQLFSVLIVAI 443
Cdd:cd17455 316 DLGYL-IVVFVTGGVLGFFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGIIFTLI 375
|
|
| MFS_DIRC2 |
cd17397 |
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; ... |
84-454 |
1.51e-27 |
|
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; Disrupted in renal carcinoma protein 2 or disrupted in renal cancer protein 2 (DIRC2), encoded by the SLC49A4 gene, was initially identified as a breakpoint-spanning gene in a chromosomal translocation associated with the development of renal cancer. It is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. DIRC2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340955 [Multi-domain] Cd Length: 381 Bit Score: 114.32 E-value: 1.51e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 84 RWFLLVSVALLNFSNTCSWIAYAPVGNYVNALYGEESA--AWFSMIYMFVSVPFGFIGMYIGSKNTLNVPLIAACVLNAI 161
Cdd:cd17397 2 RWYILLVFSLLAFTQGAVWNTWGPIADSAKPAFGWSDSdiALLANWGPIGFVPTFFFMAWLMDVKGLRIAVLSSAFLVAA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 162 GALIRALStqpqVDPQNRFPICLLGQSIAAMAYPFIMFLPSKISATCFPPSQRTIATTIGVMANPLGVMVVNLVAPLIVQ 241
Cdd:cd17397 82 GTGLRCIP----VPNHLATWLIHIGQFLNGLAGPVAMAAAPFLSATWFPPNQRATATAIASIFNYLGGAASFLIGPLVLM 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 242 SSDDVWI-LNVILFIICFVAlffagcslgclKPDE------TKQRKSndYATSCGSVFGNLNYDILMFALGGGIGMFNSL 314
Cdd:cd17397 158 YLEFGWSaLIFLAMLIYFPS-----------KPPTppsvsaSTQRLS--YKSGILSLLKNKRFWLIALAYGIPTGVYAGW 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 315 YTMMLQMLCPSGYGNQVAGICAVLMIGCGMIGATVASIYVDKHKNYRTAMIVLMnFAVIFGvGFLWMS-----KVPNMSL 389
Cdd:cd17397 225 SGVLDVNLTPFGVSQVEAGWIGFYSTVAGCVGGIIVGRFADRFGGRMKLILLLL-FSGATG-SFLWFTliclkLLPFSTV 302
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17539122 390 ILFFISGAFGFCGLAAYPVGLELAIECTYPAAPEVSSGFIVLVGQLFSVLIVAIIKIGAKSLSFV 454
Cdd:cd17397 303 SLYTSCILLGVFLNGSVPLFYELAVEAAYPVPEGITSGVLTFLNNVFGLVFLLILIIPNIGTSWM 367
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
91-454 |
1.31e-18 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 87.87 E-value: 1.31e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 91 VALLNFSNTCSWIAYAPVGNYVNALYGEESA------AWFSMIYMFVSVPFGFIGMYIGSKNTLnvplIAACVLNAIGAL 164
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASqlgllfALFSLGYALLQPLAGLLADRFGRRPVL----LLGLLLFALGAL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 165 IRALSTQpqvdpqnrFPICLLGQSIAAMAYPFIMFLPSKISATCFPPSQRTIATTIGVMANPLGVMVVNLVAPLIVQSSD 244
Cdd:cd06174 77 LFAFAPS--------FWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLG 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 245 DVW----ILNVILFIICFVALFFAGCSLGCLKPDETKQRKSNDYATSCGSVFGNLNY---DILMFALGGGIGMFNSLYTM 317
Cdd:cd06174 149 FGWravfLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLwllLLAIFLVNLAYYSFSTLLPL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 318 MLQMLcpSGYGNQVAGICAVLMIGCGMIGATVASIYVDKHKNyRTAMIVLMNFAVIFGVGFLWMSKVPNMSLILFFIsga 397
Cdd:cd06174 229 FLLDL--GGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIG-RKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLL--- 302
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 398 FGFCGLAAYPVGLELAIECTYPAAPEVSSGFIVLVGQLFSV---LIVAIIKIGAKSLSFV 454
Cdd:cd06174 303 LGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAigpLLAGFLLAATFGLTGA 362
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
80-439 |
2.86e-14 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 74.24 E-value: 2.86e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 80 SDGSRWFLLVSVALLNFSNTCSWIAYAPVGNYVNALYG--EESAAWFSMIYMFVSV----PFGFIGMYIGSKNTLnvplI 153
Cdd:COG2814 4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGasPAQAGLVVTAYLLGAAlgapLAGRLADRFGRRRVL----L 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 154 AACVLNAIGALIRALSTQpqvdpqnrFPICLLGQSIAAMAYPFIMFLPSKISATCFPPSQRTIATTIGVMANPLGVMVVN 233
Cdd:COG2814 80 LGLLLFALGSLLCALAPS--------LWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGP 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 234 LVAPLIVQSSD--DVWILNVILFIICFVALFFAgcslgcLKpdETKQRKSNDYATSCGSVFGN---LNYDILMFALGGGI 308
Cdd:COG2814 152 LLGGLLADLFGwrWVFLVNAVLALLALLLLLRL------LP--ESRPAARARLRGSLRELLRRprlLLLLLLAFLLGFGF 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 309 GMFNSLYTMMLQMLcpSGYGNQVAGICAVLMIGCGMIGATVASIYVDKHKNYRTAMIVLmnfaVIFGVGFLWMSKVPNMS 388
Cdd:COG2814 224 FALFTYLPLYLQEV--LGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGL----LLLALGLLLLALAGSLW 297
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 17539122 389 LILFFIsGAFGFCGLAAYPVGLELAIECTYPAAPEVSSGFIVLVGQLFSVL 439
Cdd:COG2814 298 LLLLAL-FLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
84-504 |
6.24e-12 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 67.20 E-value: 6.24e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 84 RWFLLVSVALLNFSNTCSWIAYAPVGNYVNALYGEESA------AWFSMIYMFVSVPFGFIGMYIGSKNTLNVPLIAACV 157
Cdd:COG2271 8 RWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAqlgllaSAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 158 LNAIGALIRALSTqpqvdpqnrFPICLLGQSIA-AMAYPFIMflpsKISATCFPPSQRTIATTIGVMANPLGVMVVNLVA 236
Cdd:COG2271 88 ATLLFGFATSFWQ---------LLLLRFLLGLGeAGFFPAAL----KLIAEWFPPKERGRALGIFNAGGPLGGALAPPLL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 237 PLIVQSSD--DVWILNVILFIICFVALFFAGCslgclkpdetkqrksndyatscgsvfgnlnydILMFALGGGIGMFNSL 314
Cdd:COG2271 155 GWLLAAFGwrAAFLILGLPGLLLALLRFWLLA--------------------------------LAYFLVYFALYGFLTW 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 315 YTMMLQMLcpSGYGNQVAGICAVLMIGCGMIGATVASIYVDKHKNYRTAMIVLmnFAVIFGVGFLWMSKVPNMSLILFFI 394
Cdd:COG2271 203 LPTYLVEV--RGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAI--GLLLAALALLLLALLPSPALAIALL 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 395 SgAFGFCGLAAYPVGLELAIECTYPAAPEVSSGFIVLVGQLFSVLIVAIIkigakslSFVDSDFGveacrahaedainvp 474
Cdd:COG2271 279 F-LAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLV-------GYLLDATG--------------- 335
|
410 420 430
....*....|....*....|....*....|
gi 17539122 475 knYDNPIIIITFIAVLIAIVVWFLREDYRR 504
Cdd:COG2271 336 --YQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
82-508 |
7.25e-12 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 67.21 E-value: 7.25e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 82 GSRWFLLVSVALLNFSNTCSWIAYAPVGNYVNALYG--EESAAW----FSMIYMFVSVPFGFIGMYIGSKNTLnvplIAA 155
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGlsAAQLGLlfaiPVLVGALLRIPLGFLVDRFGPRRVL----LIG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 156 CVLNAIGALIRALSTQpqvdpqnrFPICLLGQSI----AAMAYPFIMFLPSKIsatcFPPSQRTIATTIGVMANPLGVMV 231
Cdd:COG2223 77 LLLLGIGLLLLALAVS--------YWLLLLLGLLlgigGGGSFAVGIALVSKW----FPPDRRGLALGLAAGGGNLGAAV 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 232 VNLVAPLIVQSSDdvwILNVILFIICFVALFFAGCSLGCLKPDETKQRKSNDYATSCGSVFGNLNYDILMFAL----GGG 307
Cdd:COG2223 145 AAFLAPLLIAAFG---WRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEALRDPRFWLLSLLYfgtfGSF 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 308 IGMFNSLYTMMLQMLcpsGYGNQVAGICAVLMIGCGMIGATVASIYVDKHKNYRTAMIVLmnfaVIFGVGFLWMSKVPNM 387
Cdd:COG2223 222 IGFSSWLPPYLVDQF---GLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVF----ALMALGLLLLALALGS 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 388 SLILFFISGAFGFCGLAAYPVglelaiecTYPAAPEVS--------SGFIVLVGQLFSVLIVAIIKIgakslsfvdsdfg 459
Cdd:COG2223 295 LWLFLVLFLLLGLALGGGNGA--------VFALVPDIFptknagavYGLVGAAGGLGGFLGPLLFGA------------- 353
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 17539122 460 veacrahaedAINVPKNYDNPIIIITFIAVLIAIVVWFLREDYRRLRRE 508
Cdd:COG2223 354 ----------LLDATGSYTAAFLVFAVLALVALVLTLLLYRRPRRAAAA 392
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
70-439 |
3.10e-11 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 65.28 E-value: 3.10e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 70 SRSSIISAFESDGSRWFLLVSVALLNFSNTCSWIAYAPVGNYVNALYG--EESAAWFSMIYMFVSVPFGFIGMYIGSKNT 147
Cdd:COG2807 2 STTSSSARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGlsATQAGLLTTLPLLAFGLFAPLAPRLARRFG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 148 LNVPLIAACVLNAIGALIRALSTQpqvdpqnrFPICLLGQSIAAMAYPFIMFLPSKISATCFpPSQRTIATTIGVMANPL 227
Cdd:COG2807 82 LERTLLLALLLLAAGLLLRSLAPS--------VALLLAGTALIGAGIAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 228 GVMVVNLVAPLIVQSSD-----DVWILNVILFIICFVALFfagcslgclkpdetKQRKSNDYATSCGSVFGNLNYDILMF 302
Cdd:COG2807 153 GAALAAGLTVPLAAALGwrgalAVWALLALLALLLWLPLL--------------RRRPAAAAAAPAAASLRSLWRSPLAW 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 303 ALGGGIGMFNSLYTMML----QMLCPSGYGNQVAGICAVLMIGCGMIGATVASIYVDKHKNYRTAMIVlmnFAVIFGVGF 378
Cdd:COG2807 219 LLTLFFGLQSLLYYAVVawlpPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLL---LGLLGLAGL 295
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17539122 379 LWMSKVPNMSLILFFIsgAFGFCGLAAYPVGLELAIECTYPAAPEVS-SGFIVLVGQLFSVL 439
Cdd:COG2807 296 LGLLLAPGSLPWLWAV--LLGLGQGGLFPLALTLIGLRARTPAEAAAlSGMAQSVGYLLAAL 355
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
91-439 |
7.00e-11 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 63.98 E-value: 7.00e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 91 VALLNFSNTCSWIAYAPV-GNYVNALYG--EESAAWFSMIYMFVSVPFGFIGMYIGSKNTLNVPLIAACVLNAIGALIRA 167
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPAlPLLLAEDLGisPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 168 LSTQpqvdpqnrFPICLLGQSIAAMAYPFIMFLPSKISATCFPPSQRTIATTIGVMANPLGVMVVNLVAPLIVQSSD--D 245
Cdd:pfam07690 81 FASS--------LWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGwrA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 246 VWILNVILFIICFVALFFagcslGCLKPDETKQRKSNDYATSCGSVFGNLNYD---ILMFALGGGIGMFNSLYTMMLQML 322
Cdd:pfam07690 153 AFLILAILSLLAAVLLLL-----PRPPPESKRPKPAEEARLSLIVAWKALLRDpvlWLLLALLLFGFAFFGLLTYLPLYQ 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 323 CPSGYGNQVAGICAVLMIGCGMIGATVASIYVDKHKNyRTAMIVLMNFAVIFGVGFLWMSKVPNMSLILFFISgAFGFCG 402
Cdd:pfam07690 228 EVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGR-RRRLLLALLLLILAALGLLLLSLTLSSLWLLLALL-LLGFGF 305
|
330 340 350
....*....|....*....|....*....|....*..
gi 17539122 403 LAAYPVGLELAIECTYPAAPEVSSGFIVLVGQLFSVL 439
Cdd:pfam07690 306 GLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGAL 342
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
124-431 |
9.00e-08 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 54.47 E-value: 9.00e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 124 FSMIYMFVSVPFGFIGMYIGSKNTlnvpLIAACVLNAIGALIRALSTQpqvdpqnrFPICLLGQSIAAMAYPFIMFLPSK 203
Cdd:COG0738 52 FFLGYLLASLPAGRLIDRFGYKRG----LLLGLLLMALGLLLFALAPS--------YPLLLLALFLLGLGLGLLDVAANP 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 204 ISATCFPPSQRTIATTIGVMaNPLGVMVVNLVAPLIVQSSDDVWILNVILFIICFVALFFAGCSLGCLKPDETKQRKSND 283
Cdd:COG0738 120 YVAALGPETAASRLNLLHAF-FSLGALLGPLLGGLLILLGLSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAG 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 284 YATSCGSVFGNLNYDILMFAL----GGGIGMFNSLYTMMLQMLcpsGYGNQVAGICAVLMIGCGMIGATVASIYVDKHKN 359
Cdd:COG0738 199 SAASLKSLLKNPRLLLGGLAIflyvGAEGAIGDWLPLYLKDVL---GLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGP 275
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17539122 360 YRtamiVLMNFAVIFGVGFLWMSKVPNMSLILFFIsGAFGFCGLAAYPVGLELAIECTYPAAPEVSSGFIVL 431
Cdd:COG0738 276 VR----LLRLSALLAAVGLLLALLAPGPWLALIGL-ALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIM 342
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
152-406 |
6.29e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 51.83 E-value: 6.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 152 LIAACVLNAIGALirALSTQPQVDPQNRFPICLLGQSIAAMAY-----PFIMFLPSKISatcfPPSQRTIATTIGVMANP 226
Cdd:COG2211 84 ILIGAIPLALSFV--LLFTAPDLSPTGKLIYALVTYLLLGLAYtlvniPYSALGAELTP----DYEERTRLSSWRFAFAG 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 227 LGVMVVNLVAPLIVQSSDDVWILNVILFIICFVALFFAG---CSLGCLKPDETKQRKSNdYATSCGSVFGNLNYDILMFA 303
Cdd:COG2211 158 LGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAfllTFFGTKERPVPEEEKVS-LKESLKALLKNRPFLLLLLA 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 304 ---LGGGIGMFNSLYT-MMLQMLcpsGYGNQVAGICAVLMIGCGMIGATVASIYVDKHKNYRTAMIVLmnfaVIFGVGFL 379
Cdd:COG2211 237 yllFFLALALVAALLLyYFKYVL---GLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGL----LLAALGLL 309
|
250 260
....*....|....*....|....*..
gi 17539122 380 WMSKVPNMSLILFFISGAFGFCGLAAY 406
Cdd:COG2211 310 LLFFLGPGNLWLLLVLAALAGIGLGAI 336
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
211-495 |
1.12e-05 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 47.98 E-value: 1.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 211 PSQRTIATTIGVMANPLGVMVVNLVAPLIVQSSDD------VWILNVILFIICFVALFFagCSLGCLKPDE--TKQRKSN 282
Cdd:cd17332 131 PEERTSLTSWRMFFATIGGLLVTVLPPPLVAYFGGgnasrgYFLTALIIGIIGIILLLI--CFFGTRERVVppEEEKSKL 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 283 DYATSCGSVFGN---LNYDILMFALGGGIGMFNSLYTMMLQMLcpsgYGNQVAGICAVLMIGCGMIGATVASIYVDKHKN 359
Cdd:cd17332 209 PLLKSLKALLKNrpfLILLLAYLLYFLAFNIVNTVLVYYFKYV----LGGRAELVLLLLLILSGALLALLPWPPLKKRFG 284
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 360 YRTAMIVLMNFAVIFGVGFLWMSKVpnmSLILFFISGAFGFCGLAAyPVGLELAIectYPAAPEVS-------------- 425
Cdd:cd17332 285 KKKAFFIGLLLAILGLLLLFFLPPG---NLVLILVLAVLAGIGYGG-ANLLPWAM---LADVIDYGelktgkrregifys 357
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17539122 426 -SGFIVLVGQLFSVLIVAIIkigaksLSFVDSDFGVEACRAHAEDAINVpknydnPIIIITFIAVLIAIVV 495
Cdd:cd17332 358 vMTFFRKLGLALAGALVGLI------LSLAGYVANAAAQSASALNGIRL------LIAVLPAVLLLLALIL 416
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
118-439 |
3.17e-05 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 46.39 E-value: 3.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 118 EESAAWFSMIYMFV----SVPFGFIGMYIGSKNTLnvplIAACVLNAIGALIRALSTQpqvdpqnrFPICLLGQSIAAMA 193
Cdd:cd17324 33 VAQAGLLVSAYALGyalgALLLGPLSDRIERRRLL----LVLLLLFILGNLLAALAPS--------FALLLLARALAGLA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 194 YPFIMFLPSKISATCFPPSQRTIATTIGVMANPLGVMVVNLVAPLIVQSSDDVWILNVI--LFIICFVALFFAgcslgcL 271
Cdd:cd17324 101 HGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIavLALLAALLLWRL------L 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 272 KPDETKQRKSNDYATSCGSVFGN----LNYDILMFALGGGIGMFNSLYTMMLQMlcPSGYGNQVAGICAVLMIGcGMIGA 347
Cdd:cd17324 175 PSLPPKKPGSLGLLSSLLLLLRNprlrLAYLITFLLFGGFFALYTYLAPFLTDV--PGFSSSAIIGLLLLFGVA-GVVGS 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 348 TVASIYVDKHKNyRTAMIVLMNFAVIFGVGFLWMSKVPNMSLILFFISGAFGFCGLAAYPVGLELAiectyPAAPEVSSG 427
Cdd:cd17324 252 PLAGRLADRGGR-RALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLA-----PEARGLASS 325
|
330
....*....|..
gi 17539122 428 FIVLVGQLFSVL 439
Cdd:cd17324 326 LYLAAYNLGGAL 337
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
210-407 |
5.43e-04 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 42.68 E-value: 5.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 210 PPSQRTIATTIGVMANPLGVMVVNLVAPLIV------QSSDDVWILNVILFIICFVALFFAGCS-----LGCLKPDETKQ 278
Cdd:pfam13347 128 DYDERTSLTSYRSFFSVGGGLLAAALAFPLVlilggtGLERKGYRIFALIGAVLMLLGVIITAAgtkerVSMRSKEDTGQ 207
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 279 RKSNDYATSCGSVFGNLNYDILMF-----ALGGGIGMFNSLYTMMLQMlcpsGYGNQVAGICAVLMIGcgMIGATVASIY 353
Cdd:pfam13347 208 KEAGSLLDMLKEVFRNRAFLILLAsfllaALAMGVLNGLLLYYFRYVL----GNGFAASAFPLVFTIG--ALLGIPLWPP 281
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 17539122 354 VDKHKNYRTAMIVLMNFAVIFGVGFLWMSKVPNMSLILFFISGAFGFCGLAAYP 407
Cdd:pfam13347 282 LAKRIGKKNTYILGALITIAGFALALLLGPNNTLLFLVLYIIIGFGYGSSFFLP 335
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
123-499 |
5.78e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 42.16 E-value: 5.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 123 WFSMIYMFVS----VPFGFIGMYIGSKNTLNVPLiaacVLNAIGALIRALSTQPqvdpqnrfPICLLGQSIAAMAYPFIM 198
Cdd:cd17321 35 WVVNAYLLAFaallLLAGRLGDRFGRKRVFLIGL----ALFGLASLLCALAPSL--------AFLIAARALQGIGAAAIM 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 199 FLPSKISATCFPPSQRTIATTIGVMANPLGVMVVNLVAPLIVQSSDDVWILnVILFIICFVALFFAgcslgclkpdetkq 278
Cdd:cd17321 103 PASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIF-LINVPIGLVALLLA-------------- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 279 rksndyATSCGSVfgnlnydILMFALGGGIGMFNSLYTMMLQMLCpsGYGNQVAGICAVLMIGCGMIGATVASIYVDKHk 358
Cdd:cd17321 168 ------RTFSGAV-------LAAFLLGAALGGLLFLLPLYLQGVL--GYSPLQAGLALLPLALAMLVAAPLAGRLADRF- 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 359 NYRTAMIVLMnfaVIFGVGFLWMSKVPNMSLILFFIsGAFGFCGLA---AYPVGLELAIEctypAAPE----VSSGFIVL 431
Cdd:cd17321 232 GPRLVLVAGL---LLTAVGLLLLALLGADSSVWLLL-PGLVLLGLGlglFATPLTNAALS----SVPKekagAASGILNT 303
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17539122 432 VGQLFSVLIVAII-KIGAKSLSFVDSDFGVEACRAHAEDAINVpkNYDNPIIIITFIAVLIAIVVWFLR 499
Cdd:cd17321 304 ARQLGGALGVALLgALLTAGLSANLGDSGVAALLSAAAAAFAA--GFHLAFLVAAALALLAALLALLLP 370
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
84-399 |
2.86e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 40.29 E-value: 2.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 84 RWFLLVSVallnFSNTCSWIAYAPVGNYVnaLYGEESAAWFSMIYMFVSVPFGFIGMYIG------SKNTLnvpLIAACV 157
Cdd:cd06173 2 RLLWLAQL----LSALGDWIFTVALPWLV--LQLTGSALLVGLVLAAFFLPFLLFSPFAGvladrfDRRRL---LILADL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 158 LNAIGALIralstqpqvdpqnrFPICLLGQSIAAMAYPFIMFLPSKISATCFPPSQRTIATTIG----VMANPLGVMVVN 233
Cdd:cd06173 73 LRALLAAV--------------LALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPkeqlVRANALNSLATQ 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 234 L-------VAPLIVQSSDDVW--ILNVILFIICFVALFFAgcslgCLKPDETKQRKSNDYATSCGSVFGNLNYDILMFAL 304
Cdd:cd06173 139 LariigpaLGGLLVALLGPGGafAINALSFLLSALLLLFI-----RRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 305 GGGIGMFNSLYTMMLQMLCP-----SGYGNQVAGIcAVLMIGCGMIGATVASIYVDKHKNYRTAMIVLMnfaVIFGVGFL 379
Cdd:cd06173 214 LLALALFALLGGALTVLLPLlakevLGGGAAGYGL-LLAAFGVGALLGALLLGRLSKRRRRGRLLLIGA---LLLGLALL 289
|
330 340
....*....|....*....|..
gi 17539122 380 WMSKVPN--MSLILFFISGAFG 399
Cdd:cd06173 290 VLGLSPSlwLLLAALFLLGLAG 311
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
310-415 |
7.50e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 38.69 E-value: 7.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 310 MFNSLYTMMLQMLCPSGYGNQVAGICAVLMIGCGMIGATVASIYVDKHkNYRTAMIVLMNFAVIFGVGFLWMSkvPNMSL 389
Cdd:cd17478 210 VLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRF-GRRRVIIASLLLAAPFLLLFLLTP--GIWSY 286
|
90 100
....*....|....*....|....*.
gi 17539122 390 ILFFIsgaFGFCGLAAYPVGLELAIE 415
Cdd:cd17478 287 ILLVL---AGFLLFASFPVTVVLAQE 309
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
84-394 |
7.74e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 38.75 E-value: 7.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 84 RWFLLVSVALLNFSNTCSWIaYAPVgnYVNALYGEESAA--WFSMIYMFVSVPFGFIGMYI----GSKNTLnvplIAACV 157
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWP-FMAI--YLHQQLGLSASIvgLVLALSAVAGIVASLIGGRLadrfGRKPVM----LAGLL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 158 LNAIGALIRALStqpqvdpqNRFPICLLGQSIAAMAYPFIMFLPSKISATCFPPSQRTIATTIGVMANPLGVMVVNLVAP 237
Cdd:cd17329 74 LRALGFALLGFA--------HSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGG 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 238 LIVQSS-DDVWILNVILFIICFVALFFAgcsLGCLKPDETKQRKSNDYAtSCGSVFGNLNYDILMFALGGGIGMFNSLYT 316
Cdd:cd17329 146 LLLLYSfRLLFLAAAVLFLLAALVLLFL---LPETRPKRRAAEKTEILR-GYKIVLRDRAFLLFLLASFLISLIYFQLES 221
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17539122 317 MMLQMLCPSGyGNQVAGICAVLMIGCGMI-GATVASIYVDKHKNYRTAMIVLMnfaVIFGVGFLWMSKVPNMSLILFFI 394
Cdd:cd17329 222 TLPVYVVEIL-GLGESLLGLLLALNALLIvLLQFPVARLVERFRLRKILMIGI---LLFAIGFAVLAFANTLAVLILAM 296
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
210-413 |
7.89e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 38.69 E-value: 7.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 210 PPSQRTIATTIGVMANPLGVMVVNLVAPLIVQSSDDVWILNVILFIICFVALFFAGCSLGCLKPDETKQRKSNdYATSCG 289
Cdd:cd17477 114 TNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGALPFLIAAVLLLLALVPLLLTRRAAPEIEEAESISLRRL-LRIAPL 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539122 290 SVFGnlnydilMFALGGGIGMFNSLYTMMLQMLcpsGYGNQVAGICAVLMIGCGMIGATVASIYVDKHkNYRTAMIVLmn 369
Cdd:cd17477 193 ALLG-------AFVAGFLEGAFYSLLPLYGLRL---GLSVAQAALLLAAFVLGGLLLQWPLGWLADRF-DRRRVLLGC-- 259
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 17539122 370 fAVIFGVGFLWMSKVPNMSLILFFISGAFGFCGLAAYPVGLELA 413
Cdd:cd17477 260 -ALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALA 302
|
|
| |
