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Conserved domains on  [gi|193206373|ref|NP_502195|]
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NUC153 domain-containing protein [Caenorhabditis elegans]

Protein Classification

ESF1 family protein( domain architecture ID 1002617)

ESF1 family protein similar to Homo sapiens ESF1 pre-rRNA-processing protein homolog, which may constitute a novel regulatory system for basal transcription

Gene Ontology:  GO:0003723|GO:0006364

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
COG5638 super family cl35032
Uncharacterized conserved protein [Function unknown];
205-592 2.90e-28

Uncharacterized conserved protein [Function unknown];


The actual alignment was detected with superfamily member COG5638:

Pssm-ID: 227925 [Multi-domain]  Cd Length: 622  Bit Score: 119.89  E-value: 2.90e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206373 205 SNRLAVCNLEWDTMNCEDILMLVKSFVPQGGSVISVGIYLSDFGKGQLSKEEKTGPLLKLAKPVEEYK------------ 272
Cdd:COG5638  146 TKRLAVVNMDWDRVDAKDLFKIFSSFLPYGGKLSKVKIYPSEFGKERMAAEHVQGPPRDIFTPADNQPssqkfgddnvfs 225
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206373 273 -----------EDEMDDETRTAVREYLVNKLKYYYSVITFDSIPSAVAVYEECDGFQFEETGLKMDMRFIPDDMDFEEDR 341
Cdd:COG5638  226 drdagedalieGDRGNEFDMVKLRQYQLERLRYYYAVVECEDIETSKNIYSACDGVEYENSANVLDLRFVPDSLTFDDDS 305
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206373 342 VKEFLNAEDvnltKYKAKKKSKSAIISTGAKILWDEDDPQRKKKFLEAFNGDEDAGKDLIV-----DSDESDGDEaNRKT 416
Cdd:COG5638  306 REVCTKAPE----KYEPRDFVTDALQHSKVKLSWDAEDPHRKDLCKEAFTDDGIRDKDFSAytaskLSDEDDDSV-MESK 380
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206373 417 LMALLNTDE------------------------RKSKLDVDWEGEEKNGSDSSDGEY----------------------- 449
Cdd:COG5638  381 MQKLFSEKEidfglnselvdmsddgengemedtFTSHLPASNESESDDKLETTIEKLdrklrerqenrkerqlkktkdds 460
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206373 450 -VKVDDDDEEIGVKQKKKKGSDDDEDEKEEVEEKKEDVKLTGYKAYKKKQKQKLMENKLKRKGTSKEAETNIKTVAAADs 528
Cdd:COG5638  461 dVDLKDKKESINKKNKKGKHAIERTAASKEELELIKADDEDDEQLDHFDMKSILKAEKFKKNRKLKKKASNLEEGFVFD- 539
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 193206373 529 iSKDDRFSALFTDSAYAIEPSSKKFKGSLLVTKQAEQKSKGSSTVIEtkKPEDLVQKLKKQADK 592
Cdd:COG5638  540 -PKDPRFVAIFEDHNFAIDPTHPEFKKTGGMKKIMDEKRKRLKNNIE--QTQDGKPELKIKKRK 600
 
Name Accession Description Interval E-value
COG5638 COG5638
Uncharacterized conserved protein [Function unknown];
205-592 2.90e-28

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 227925 [Multi-domain]  Cd Length: 622  Bit Score: 119.89  E-value: 2.90e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206373 205 SNRLAVCNLEWDTMNCEDILMLVKSFVPQGGSVISVGIYLSDFGKGQLSKEEKTGPLLKLAKPVEEYK------------ 272
Cdd:COG5638  146 TKRLAVVNMDWDRVDAKDLFKIFSSFLPYGGKLSKVKIYPSEFGKERMAAEHVQGPPRDIFTPADNQPssqkfgddnvfs 225
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206373 273 -----------EDEMDDETRTAVREYLVNKLKYYYSVITFDSIPSAVAVYEECDGFQFEETGLKMDMRFIPDDMDFEEDR 341
Cdd:COG5638  226 drdagedalieGDRGNEFDMVKLRQYQLERLRYYYAVVECEDIETSKNIYSACDGVEYENSANVLDLRFVPDSLTFDDDS 305
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206373 342 VKEFLNAEDvnltKYKAKKKSKSAIISTGAKILWDEDDPQRKKKFLEAFNGDEDAGKDLIV-----DSDESDGDEaNRKT 416
Cdd:COG5638  306 REVCTKAPE----KYEPRDFVTDALQHSKVKLSWDAEDPHRKDLCKEAFTDDGIRDKDFSAytaskLSDEDDDSV-MESK 380
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206373 417 LMALLNTDE------------------------RKSKLDVDWEGEEKNGSDSSDGEY----------------------- 449
Cdd:COG5638  381 MQKLFSEKEidfglnselvdmsddgengemedtFTSHLPASNESESDDKLETTIEKLdrklrerqenrkerqlkktkdds 460
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206373 450 -VKVDDDDEEIGVKQKKKKGSDDDEDEKEEVEEKKEDVKLTGYKAYKKKQKQKLMENKLKRKGTSKEAETNIKTVAAADs 528
Cdd:COG5638  461 dVDLKDKKESINKKNKKGKHAIERTAASKEELELIKADDEDDEQLDHFDMKSILKAEKFKKNRKLKKKASNLEEGFVFD- 539
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 193206373 529 iSKDDRFSALFTDSAYAIEPSSKKFKGSLLVTKQAEQKSKGSSTVIEtkKPEDLVQKLKKQADK 592
Cdd:COG5638  540 -PKDPRFVAIFEDHNFAIDPTHPEFKKTGGMKKIMDEKRKRLKNNIE--QTQDGKPELKIKKRK 600
NUC153 pfam08159
NUC153 domain; This small domain is found in a a novel nucleolar family.
532-554 1.01e-04

NUC153 domain; This small domain is found in a a novel nucleolar family.


Pssm-ID: 462385 [Multi-domain]  Cd Length: 29  Bit Score: 39.62  E-value: 1.01e-04
                          10        20
                  ....*....|....*....|...
gi 193206373  532 DDRFSALFTDSAYAIEPSSKKFK 554
Cdd:pfam08159   1 DPRFKALFEDHDFAIDPTSPEFK 23
 
Name Accession Description Interval E-value
COG5638 COG5638
Uncharacterized conserved protein [Function unknown];
205-592 2.90e-28

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 227925 [Multi-domain]  Cd Length: 622  Bit Score: 119.89  E-value: 2.90e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206373 205 SNRLAVCNLEWDTMNCEDILMLVKSFVPQGGSVISVGIYLSDFGKGQLSKEEKTGPLLKLAKPVEEYK------------ 272
Cdd:COG5638  146 TKRLAVVNMDWDRVDAKDLFKIFSSFLPYGGKLSKVKIYPSEFGKERMAAEHVQGPPRDIFTPADNQPssqkfgddnvfs 225
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206373 273 -----------EDEMDDETRTAVREYLVNKLKYYYSVITFDSIPSAVAVYEECDGFQFEETGLKMDMRFIPDDMDFEEDR 341
Cdd:COG5638  226 drdagedalieGDRGNEFDMVKLRQYQLERLRYYYAVVECEDIETSKNIYSACDGVEYENSANVLDLRFVPDSLTFDDDS 305
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206373 342 VKEFLNAEDvnltKYKAKKKSKSAIISTGAKILWDEDDPQRKKKFLEAFNGDEDAGKDLIV-----DSDESDGDEaNRKT 416
Cdd:COG5638  306 REVCTKAPE----KYEPRDFVTDALQHSKVKLSWDAEDPHRKDLCKEAFTDDGIRDKDFSAytaskLSDEDDDSV-MESK 380
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206373 417 LMALLNTDE------------------------RKSKLDVDWEGEEKNGSDSSDGEY----------------------- 449
Cdd:COG5638  381 MQKLFSEKEidfglnselvdmsddgengemedtFTSHLPASNESESDDKLETTIEKLdrklrerqenrkerqlkktkdds 460
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206373 450 -VKVDDDDEEIGVKQKKKKGSDDDEDEKEEVEEKKEDVKLTGYKAYKKKQKQKLMENKLKRKGTSKEAETNIKTVAAADs 528
Cdd:COG5638  461 dVDLKDKKESINKKNKKGKHAIERTAASKEELELIKADDEDDEQLDHFDMKSILKAEKFKKNRKLKKKASNLEEGFVFD- 539
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 193206373 529 iSKDDRFSALFTDSAYAIEPSSKKFKGSLLVTKQAEQKSKGSSTVIEtkKPEDLVQKLKKQADK 592
Cdd:COG5638  540 -PKDPRFVAIFEDHNFAIDPTHPEFKKTGGMKKIMDEKRKRLKNNIE--QTQDGKPELKIKKRK 600
NUC153 pfam08159
NUC153 domain; This small domain is found in a a novel nucleolar family.
532-554 1.01e-04

NUC153 domain; This small domain is found in a a novel nucleolar family.


Pssm-ID: 462385 [Multi-domain]  Cd Length: 29  Bit Score: 39.62  E-value: 1.01e-04
                          10        20
                  ....*....|....*....|...
gi 193206373  532 DDRFSALFTDSAYAIEPSSKKFK 554
Cdd:pfam08159   1 DPRFKALFEDHDFAIDPTSPEFK 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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