|
Name |
Accession |
Description |
Interval |
E-value |
| COG5028 |
COG5028 |
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ... |
381-1123 |
7.52e-166 |
|
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];
Pssm-ID: 227361 [Multi-domain] Cd Length: 861 Bit Score: 512.03 E-value: 7.52e-166
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 381 PNAELPPLVSTNSFAQDQGNCNPKFMRSTLYTAPQTNDILKASQIPLAVVISPFASLTEYEKEPPVVDLGPqgPIRCQRC 460
Cdd:COG5028 128 PPPPIVPPLTTNFVGSEQSNCSPKYVRSTMYAIPETNDLLKKSKIPFGLVIRPFLELYPEEDPVPLVEDGS--IVRCRRC 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 461 KAYICPFMEFQDGGRSFRCPFCHARTSVEDAYFAHLDHTGRRTDIEMRPELCLGAYDLVATKQYckNGIAPKEPAFIFMI 540
Cdd:COG5028 206 RSYINPFVQFIEQGRKWRCNICRSKNDVPEGFDNPSGPNDPRSDRYSRPELKSGVVDFLAPKEY--SLRQPPPPVYVFLI 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 541 DVSYNAISNGMLPILcqnLEKVLRNLPRESgQLESSMRIGLATFDQAVHFFDISSASPK-MLVMSDVQEPFVPMVDG-LL 618
Cdd:COG5028 284 DVSFEAIKNGLVKAA---IRAILENLDQIP-NFDPRTKIAIICFDSSLHFFKLSPDLDEqMLIVSDLDEPFLPFPSGlFV 359
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 619 LPYNEALPGLRAALAEIPKLFSQSKTTETILQPVVQAGLDALKcaDRAGKVILFSTVLPTYdAPGKLKSKNDrsllgtdK 698
Cdd:COG5028 360 LPLKSCKQIIETLLDRVPRIFQDNKSPKNALGPALKAAKSLIG--GTGGKIIVFLSTLPNM-GIGKLQLRED-------K 429
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 699 EKNALVPQEDSYTKLGEQCVKSGVTVDLFLFPNAFIDVATIGQLSAVTGGSIFKFQYFSADK--DGVRMLNELERHVSKK 776
Cdd:COG5028 430 ESSLLSCKDSFYKEFAIECSKVGISVDLFLTSEDYIDVATLSHLCRYTGGQTYFYPNFSATRpnDATKLANDLVSHLSME 509
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 777 IAFDCMARVRTSTGIRPITFTGSFYMENSTDLELATLDESKAFITEIKHDDSLKDPASFIQTAVLYTSMTGQRRLRILNL 856
Cdd:COG5028 510 IGYEAVMRVRCSTGLRVSSFYGNFFNRSSDLCAFSTMPRDTSLLVEFSIDEKLMTSDVYFQVALLYTLNDGERRIRVVNL 589
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 857 CLPVTADYNQVYRLADPEALTAFMLKQAVQ--LNRDKGssEMRESLSSRCAQFLATYREKCSEGAPLGQLILPESLKLMP 934
Cdd:COG5028 590 SLPTSSSIREVYASADQLAIACILAKKASTkaLNSSLK--EARVLINKSMVDILKAYKKELVKSNTSTQLPLPANLKLLP 667
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 935 LYVNSILKNDAISGGSeMTVDDKVWQMELIRGLRTENVMPLIYPRVMPISDLQIND---TEEMKDLPKPVRASSEFLENS 1011
Cdd:COG5028 668 LLMLALLKSSAFRSGS-TPSDIRISALNRLTSLPLKQLMRNIYPTLYALHDMPIEAglpDEGLLVLPSPINATSSLLESG 746
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 1012 KAYIIDNGVILFVWVGSACPQTWVQDVFGVGATNQIDTESGTIPEKDNGHSRALRRAIQLLPRGIRERKTFVVVEKSGLE 1091
Cdd:COG5028 747 GLYLIDTGQKIFLWFGKDAVPSLLQDLFGVDSLSDIPSGKFTLPPTGNEFNERVRNIIGELRSVNDDSTLPLVLVRGGGD 826
|
730 740 750
....*....|....*....|....*....|....*.
gi 17539780 1092 P----WMKKFLVEDKAGpANMSYVDYLVDIHRKIRD 1123
Cdd:COG5028 827 PslrlWFFSTLVEDKTL-NIPSYLDYLQILHEKIKS 861
|
|
| Sec24-like |
cd01479 |
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the ... |
531-777 |
1.08e-108 |
|
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes of vesicular carriers within the endocytic and the biosynthetic pathways are COP- and clathrin-coated vesicles. Formation of COPII vesicles requires the ordered assembly of the coat built from several cytosolic components GTPase Sar1, complexes of Sec23-Sec24 and Sec13-Sec31. The process is initiated by the conversion of GDP to GTP by the GTPase Sar1 which then recruits the heterodimeric complex of Sec23 and Sec24. This heterodimeric complex generates the pre-budding complex. The final step leading to membrane deformation and budding of COPII-coated vesicles is carried by the heterodimeric complex Sec13-Sec31. The members of this CD belong to the Sec23-like family. Sec 24 is very similar to Sec23. The Sec23 and Sec24 polypeptides fold into five distinct domains: a beta-barrel, a zinc finger, a vWA or trunk, an all helical region and a carboxy Gelsolin domain. The members of this subgroup carry a partial MIDAS motif and have the overall Para-Rossmann type fold that is characteristic of this superfamily.
Pssm-ID: 238756 [Multi-domain] Cd Length: 244 Bit Score: 339.25 E-value: 1.08e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 531 PKEPAFIFMIDVSYNAISNGMLPILCQNLEKVLRNLPREsgqlESSMRIGLATFDQAVHFFDISSAS--PKMLVMSDVQE 608
Cdd:cd01479 1 PQPAVYVFLIDVSYNAIKSGLLATACEALLSNLDNLPGD----DPRTRVGFITFDSTLHFFNLKSSLeqPQMMVVSDLDD 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 609 PFVPMVDGLLLPYNEALPGLRAALAEIPKLFSQSKTTETILQPVVQAGLDALKcaDRAGKVILFSTVLPTYDApGKLKSK 688
Cdd:cd01479 77 PFLPLPDGLLVNLKESRQVIEDLLDQIPEMFQDTKETESALGPALQAAFLLLK--ETGGKIIVFQSSLPTLGA-GKLKSR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 689 NDRSLLGTDKEKNALVPQEDSYTKLGEQCVKSGVTVDLFLFPNAFIDVATIGQLSAVTGGSIFKFQ--YFSADKDGVRML 766
Cdd:cd01479 154 EDPKLLSTDKEKQLLQPQTDFYKKLALECVKSQISVDLFLFSNQYVDVATLGCLSRLTGGQVYYYPsfNFSAPNDVEKLV 233
|
250
....*....|.
gi 17539780 767 NELERHVSKKI 777
Cdd:cd01479 234 NELARYLTRKI 244
|
|
| Sec23_trunk |
pfam04811 |
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum ... |
531-773 |
1.31e-100 |
|
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface.
Pssm-ID: 398467 [Multi-domain] Cd Length: 241 Bit Score: 317.66 E-value: 1.31e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 531 PKEPAFIFMIDVSYNAISNGMLPILCQNLEKVLRNLPRESgqlesSMRIGLATFDQAVHFFDISS--ASPKMLVMSDVQE 608
Cdd:pfam04811 1 PQPPVFLFVIDVSYNAIKSGLLAALKESLLQSLDLLPGDP-----RARVGFITFDSTVHFFNLGSslRQPQMLVVSDLQD 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 609 PFVPMVDGLLLPYNEALPGLRAALAEIPKLFSQSKTTETILQPVVQAGLDALKCADRAGKVILFSTVLPTYDAPGKLKSK 688
Cdd:pfam04811 76 MFLPLPDRFLVPLSECRFVLEDLLEQLPPMFPVTKRPERCLGPALQAAFLLLKAAFTGGKIMVFQGGLPTVGPGGKLKSR 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 689 NDRSLLGTDKEKNALVPQEDS-YTKLGEQCVKSGVTVDLFLFPNAFIDVATIGQLSAVTGGSIFKFQYFSADKDGVRMLN 767
Cdd:pfam04811 156 LDESHHGTDKEKAKLVKKADKfYKSLAKECVKQGHSVDLFAFSLDYVDVATLGQLSRLTGGQVYLYPSFQADVDGSKFKQ 235
|
....*.
gi 17539780 768 ELERHV 773
Cdd:pfam04811 236 DLQRYF 241
|
|
| trunk_domain |
cd01468 |
trunk domain. COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi ... |
531-771 |
2.77e-87 |
|
trunk domain. COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface. Some members of this family possess a partial MIDAS motif that is a characteristic feature of most vWA domain proteins.
Pssm-ID: 238745 [Multi-domain] Cd Length: 239 Bit Score: 281.44 E-value: 2.77e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 531 PKEPAFIFMIDVSYNAISNGMLPILCQNLEKVLRNLPRESGqlessMRIGLATFDQAVHFFDISSAS--PKMLVMSDVQE 608
Cdd:cd01468 1 PQPPVFVFVIDVSYEAIKEGLLQALKESLLASLDLLPGDPR-----ARVGLITYDSTVHFYNLSSDLaqPKMYVVSDLKD 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 609 PFVPMVDGLLLPYNEALPGLRAALAEIPKLFSQ--SKTTETILQPVVQAGLDALKCADRAGKVILFSTVLPTYDaPGKLK 686
Cdd:cd01468 76 VFLPLPDRFLVPLSECKKVIHDLLEQLPPMFWPvpTHRPERCLGPALQAAFLLLKGTFAGGRIIVFQGGLPTVG-PGKLK 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 687 SKNDRSLLGTDKEKNALVPQEDSYTKLGEQCVKSGVTVDLFLFPNAFIDVATIGQLSAVTGGSIFKFQYFSADKDGVRML 766
Cdd:cd01468 155 SREDKEPIRSHDEAQLLKPATKFYKSLAKECVKSGICVDLFAFSLDYVDVATLKQLAKSTGGQVYLYDSFQAPNDGSKFK 234
|
....*
gi 17539780 767 NELER 771
Cdd:cd01468 235 QDLQR 239
|
|
| PTZ00395 |
PTZ00395 |
Sec24-related protein; Provisional |
534-1125 |
5.97e-41 |
|
Sec24-related protein; Provisional
Pssm-ID: 185594 [Multi-domain] Cd Length: 1560 Bit Score: 164.86 E-value: 5.97e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 534 PAFIFMIDVSYNAISNGMLPILCQNLEKVLRNL--PResgqlessMRIGLATFDQAVHFFDIS---------------SA 596
Cdd:PTZ00395 953 PYFVFVVECSYNAIYNNITYTILEGIRYAVQNVkcPQ--------TKIAIITFNSSIYFYHCKggkgvsgeegdggggSG 1024
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 597 SPKMLVMSDVQEPFVPmvdgllLPYNEALPGLRAALAEIPKLFSQSKTTETILQPVVQAGLDALKCA-------DRAGKV 669
Cdd:PTZ00395 1025 NHQVIVMSDVDDPFLP------LPLEDLFFGCVEEIDKINTLIDTIKSVSTTMQSYGSCGNSALKIAmdmlkerNGLGSI 1098
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 670 ILFSTVLPTYdAPGKLKSkndrslLGTDKEKNAL-VPQEDSYTKLGEQCVKSGVTVDLFLFP--NAFIDVATIGQLSAVT 746
Cdd:PTZ00395 1099 CMFYTTTPNC-GIGAIKE------LKKDLQENFLeVKQKIFYDSLLLDLYAFNISVDIFIISsnNVRVCVPSLQYVAQNT 1171
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 747 GGSIFKFQYFSADKDGVRM-LNELERHVSKKIAFDCMARVRTStgiRPITFTGSFYMENSTDlELATLDESKafITEIKH 825
Cdd:PTZ00395 1172 GGKILFVENFLWQKDYKEIyMNIMDTLTSEDIAYCCELKLRYS---HHMSVKKLFCCNNNFN-SIISVDTIK--IPKIRH 1245
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 826 DDSL-----------KDPASFIQTAVLYTSMTGQRRLRILNLCLPVTADYNQVYRLADPEALTAFMLKQAVQ--LNRDKG 892
Cdd:PTZ00395 1246 DQTFafllnysdiseSKKQIYFQCACIYTNLWGDRFVRLHTTHMNLTSSLSTVFRYTDAEALMNILIKQLCTniLHNDNY 1325
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 893 SSEMRESLssrcAQFLATYREKCSEGAPLGQLILPESLKLMPLYVNSILKNDAISggSEMTVDDKVWQmeLIRGLRTENV 972
Cdd:PTZ00395 1326 SKIIIDNL----AAILFSYRINCASSAHSGQLILPDTLKLLPLFTSSLLKHNVTK--KEILHDLKVYS--LIKLLSMPII 1397
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 973 MPLIYprVMPISDL-----QINDTEEM---KDL--PKPVRASSEFLENSKAYIIDNGVILFVWVGSACPQTWVQDVFgvg 1042
Cdd:PTZ00395 1398 SSLLY--VYPVMYVihikgKTNEIDSMdvdDDLfiPKTIPSSAEKIYSNGIYLLDACTHFYLYFGFHSDANFAKEIV--- 1472
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 1043 atnqidtesGTIPEKDNGH---------SRALRRAIQLLPRgIRERKTFV----VVEKSGLEPWMKKFLVEDKAGpANMS 1109
Cdd:PTZ00395 1473 ---------GDIPTEKNAHelnltdtpnAQKVQRIIKNLSR-IHHFNKYVplvmVAPKSNEEEHLISLCVEDKAD-KEYS 1541
|
650
....*....|....*.
gi 17539780 1110 YVDYLVDIHRKIRDLI 1125
Cdd:PTZ00395 1542 YVNFLCFIHKLVHKRI 1557
|
|
| Sec23_helical |
pfam04815 |
Sec23/Sec24 helical domain; COPII-coated vesicles carry proteins from the endoplasmic ... |
872-974 |
1.14e-28 |
|
Sec23/Sec24 helical domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is composed of five alpha helices.
Pssm-ID: 461441 [Multi-domain] Cd Length: 103 Bit Score: 110.67 E-value: 1.14e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 872 DPEALTAFMLKQAVQLNRDKGSSEMRESLSSRCAQFLATYREKCSEGAPLGQLILPESLKLMPLYVNSILKNDAISGGSE 951
Cdd:pfam04815 1 DQEAIAVLLAKKAVEKALSSSLSDAREALDNKLVDILAAYRKYCASSSSPGQLILPESLKLLPLYMLALLKSPALRGGNS 80
|
90 100
....*....|....*....|...
gi 17539780 952 MTVDDKVWQMELIRGLRTENVMP 974
Cdd:pfam04815 81 SPSDERAYARHLLLSLPVEELLL 103
|
|
| Sec23_BS |
pfam08033 |
Sec23/Sec24 beta-sandwich domain; |
778-861 |
8.17e-24 |
|
Sec23/Sec24 beta-sandwich domain;
Pssm-ID: 429794 [Multi-domain] Cd Length: 86 Bit Score: 96.45 E-value: 8.17e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 778 AFDCMARVRTSTGIRPITFTGSFYMENSTDL-ELATLDESKAFITEIKHDDSLK-DPASFIQTAVLYTSMTGQRRLRILN 855
Cdd:pfam08033 1 GFNAVLRVRTSKGLKVSGFIGNFVSRSSGDTwKLPSLDPDTSYAFEFDIDEPLPnGSNAYIQFALLYTHSSGERRIRVTT 80
|
....*.
gi 17539780 856 LCLPVT 861
Cdd:pfam08033 81 VALPVT 86
|
|
| zf-Sec23_Sec24 |
pfam04810 |
Sec23/Sec24 zinc finger; COPII-coated vesicles carry proteins from the endoplasmic reticulum ... |
454-488 |
4.16e-15 |
|
Sec23/Sec24 zinc finger; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is found to be zinc binding domain.
Pssm-ID: 461437 [Multi-domain] Cd Length: 38 Bit Score: 69.78 E-value: 4.16e-15
10 20 30
....*....|....*....|....*....|....*
gi 17539780 454 PIRCQRCKAYICPFMEFQDGGRSFRCPFCHARTSV 488
Cdd:pfam04810 1 PVRCRRCRAYLNPFCQFDFGGKKWTCNFCGTRNPV 35
|
|
| SEC23 |
COG5047 |
Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion]; |
416-885 |
7.61e-12 |
|
Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion];
Pssm-ID: 227380 [Multi-domain] Cd Length: 755 Bit Score: 69.53 E-value: 7.61e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 416 TNDILKASQIPLAVVISPFASLTEYEKEPPVVDLGPQGPIRCQR-CKAYICPFMEFQDGGRSFRCPFCHARTSVEDAYfa 494
Cdd:COG5047 15 TWNVFPATRGDATRTVIPIACLYTPLHEDDALTVNYYEPVKCTApCKAVLNPYCHIDERNQSWICPFCNQRNTLPPQY-- 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 495 hldhtgrrTDI---EMRPELCLGAydlvATKQYCKNGIAPKEPAFIFMIDVSYNAIS-NGMLPILCQNLEKvlrnLPRES 570
Cdd:COG5047 93 --------RDIsnaNLPLELLPQS----STIEYTLSKPVILPPVFFFVVDACCDEEElTALKDSLIVSLSL----LPPEA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 571 gqlessmRIGLATFDQAVHFFDISS-ASPKMLVMSDVQEPFVPMVDGLLLPYNEALP-GLRAALAEI----------PKL 638
Cdd:COG5047 157 -------LVGLITYGTSIQVHELNAeNHRRSYVFSGNKEYTKENLQELLALSKPTKSgGFESKISGIgqfassrfllPTQ 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 639 FSQSKTTETI--LQP---VVQAGLDALKCA----------------DRAGKVILF----STVLPTYDAPGKLKSK-NDRS 692
Cdd:COG5047 230 QCEFKLLNILeqLQPdpwPVPAGKRPLRCTgsalniasslleqcfpNAGCHIVLFaggpCTVGPGTVVSTELKEPmRSHH 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 693 LLGTDKEKNALVPQEdSYTKLGEQCVKSGVTVDLFLFPNAFIDVATIGQLSAVTGGSIFKFQYFSAD--KDGVRMLNELE 770
Cdd:COG5047 310 DIESDSAQHSKKATK-FYKGLAERVANQGHALDIFAGCLDQIGIMEMEPLTTSTGGALVLSDSFTTSifKQSFQRIFNRD 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 771 RHVSKKIAFDCMARVRTSTGIR-----------------------PITFTGSFYMEN-STDLELATLDESKafiTEIKHD 826
Cdd:COG5047 389 SEGYLKMGFNANMEVKTSKNLKikglighavsvkkkannisdseiGIGATNSWKMASlSPKSNYALYFEIA---LGAASG 465
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17539780 827 DSLKDPASFIQTAVLYTSMTGQRRLRI---LNLCLPVTADynQVYRLADPEALTAFMLKQAV 885
Cdd:COG5047 466 SAQRPAEAYIQFITTYQHSSGTYRIRVttvARMFTDGGLP--KINRSFDQEAAAVFMARIAA 525
|
|
| Gelsolin |
pfam00626 |
Gelsolin repeat; |
996-1069 |
5.28e-11 |
|
Gelsolin repeat;
Pssm-ID: 395501 [Multi-domain] Cd Length: 76 Bit Score: 59.63 E-value: 5.28e-11
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17539780 996 DLPKPVRASSEFLENSKAYIIDNGVILFVWVGSAcpQTWVQDVFGVGATNQIDT-ESGTIPEKDN-GHSRALRRAI 1069
Cdd:pfam00626 3 VLPPPVPLSQESLNSGDCYLLDNGFTIFLWVGKG--SSLLEKLFAALLAAQLDDdERFPLPEVIRvPQGKEPARFL 76
|
|
| PLN00162 |
PLN00162 |
transport protein sec23; Provisional |
425-727 |
3.54e-08 |
|
transport protein sec23; Provisional
Pssm-ID: 215083 [Multi-domain] Cd Length: 761 Bit Score: 57.64 E-value: 3.54e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 425 IPLAVVISPFASLTEyekePPVVdlgPQGPIRCQRCKAYICPF--MEFQdgGRSFRCPFCHARTsvedaYFAHldHTGRR 502
Cdd:PLN00162 31 IPLAALYTPLKPLPE----LPVL---PYDPLRCRTCRAVLNPYcrVDFQ--AKIWICPFCFQRN-----HFPP--HYSSI 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 503 TDIEMRPELclgaYDLVATKQY---CKNGIAPKEPAFIFMIDVsynAISNGMLPILCQNLEKVLRNLPRESgqlessmRI 579
Cdd:PLN00162 95 SETNLPAEL----FPQYTTVEYtlpPGSGGAPSPPVFVFVVDT---CMIEEELGALKSALLQAIALLPENA-------LV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 580 GLATFDQAVHFFDISSAS-PKMLVM--------SDVQE--------------PFVPMVDGL--------LLPYNEALPGL 628
Cdd:PLN00162 161 GLITFGTHVHVHELGFSEcSKSYVFrgnkevskDQILEqlglggkkrrpaggGIAGARDGLsssgvnrfLLPASECEFTL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 629 RAALAEIPKLFSQ-------SKTTETILQpvVQAGLDALKCADRAGKVILFsTVLPTYDAPG----KLKSKNDRSllGTD 697
Cdd:PLN00162 241 NSALEELQKDPWPvppghrpARCTGAALS--VAAGLLGACVPGTGARIMAF-VGGPCTEGPGaivsKDLSEPIRS--HKD 315
|
330 340 350
....*....|....*....|....*....|....
gi 17539780 698 KEKNAlVPQEDS----YTKLGEQCVKSGVTVDLF 727
Cdd:PLN00162 316 LDKDA-APYYKKavkfYEGLAKQLVAQGHVLDVF 348
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
92-279 |
1.21e-07 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 56.15 E-value: 1.21e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 92 YQPAGYPGAPPQQLQQVQRQQTPQQFAAVPQSVQAPSATPAGPLQAMQQAPAPTPGIPQMNQGAHLPPQPHQIHQPTPLR 171
Cdd:PRK07764 586 AVVGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDG 665
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 172 PQ---IPGFPQAGGSPSSFQAGAPTSQNVQGYPGGPSSAPSAYPGAPQVPQAPNSFIPPGTGGFPPGQPTAGSFP--PGP 246
Cdd:PRK07764 666 GDgwpAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPlpPEP 745
|
170 180 190
....*....|....*....|....*....|...
gi 17539780 247 QVPGSYPSGPADIPQGPGMPRAFPPGASAPVAP 279
Cdd:PRK07764 746 DDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSP 778
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
79-221 |
1.32e-07 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 55.76 E-value: 1.32e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 79 GARSTPSAQPPNPYQPAGYPGAPPQQLQQVQRQQTPQQFAAVPQSVQAPSATPAGPLQAMQQAPAPTPGIPQMNQGAHLP 158
Cdd:PRK07764 626 APAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAP 705
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17539780 159 PQPHQIHQPTPLRPQIPGFPQAGGSPSSFQAGAPTSQNVQGYPGGPSSAPSAYPGAPQVPQAP 221
Cdd:PRK07764 706 AATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAA 768
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
39-280 |
3.84e-07 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 54.94 E-value: 3.84e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 39 PAQVPGGFPPPHQQPNGQ----YQNGGLNGNSSHLAQSVNNMSIGARSTPSAQPPNPYQPAGyPGAPPQQLQQVQRQQTP 114
Cdd:PHA03247 2614 PSPLPPDTHAPDPPPPSPspaaNEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQ-ASSPPQRPRRRAARPTV 2692
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 115 QQFAAVPQSvQAPSATPAGPLQAMQQApAPTPGIPQMNQGAHLPPQPHQIHQPTPLRPQIPGFPQAGGSPSSfQAGAPTS 194
Cdd:PHA03247 2693 GSLTSLADP-PPPPPTPEPAPHALVSA-TPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPT-TAGPPAP 2769
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 195 QNVQGYPGGPSSAPSAYPGAPQVPQAPNSFIPPGTGGFPPGQPTAGSFPPGPQVP-GSYPSGPADIPQGPGMPRAFPPGA 273
Cdd:PHA03247 2770 APPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPaGPLPPPTSAQPTAPPPPPGPPPPS 2849
|
250
....*....|
gi 17539780 274 SAP---VAPG 280
Cdd:PHA03247 2850 LPLggsVAPG 2859
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
80-279 |
1.16e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 53.02 E-value: 1.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 80 ARSTPSAQPPNPYQPAGYPGAPPQQLQQVQRQQTPQQFAAvpqsvQAPSATPAGPLQAMQQAPAPTPGIPQMNQGAHLPP 159
Cdd:PHA03247 2699 ADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAA-----PAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPA 2773
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 160 QPHQIHQPTPLRPqiPGFPQAGGSPSSFQAGAPTSQNVQGYPGGPSSAPSAYPGAPQVPqaPNSfippgtggfppGQPTA 239
Cdd:PHA03247 2774 APAAGPPRRLTRP--AVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPP--PTS-----------AQPTA 2838
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 17539780 240 GSFPPGPqVPGSYPSGPADIPQGP----GMPRAFPPGASAPVAP 279
Cdd:PHA03247 2839 PPPPPGP-PPPSLPLGGSVAPGGDvrrrPPSRSPAAKPAAPARP 2881
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
77-279 |
1.33e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 53.02 E-value: 1.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 77 SIGARST-PSA--QPPNPYQPAGYPG-----APPQQLQQVQRQQTPQQFAAVPQSVQAPSATPAGPLQAMQQAPAPTPGI 148
Cdd:PHA03247 2581 AVTSRARrPDAppQSARPRAPVDDRGdprgpAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGR 2660
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 149 PQMNQGAHLPPQPHQIHQPtPLRPQIPGFPQAGGSPSSF----------QAGAPTSQNVQGYPGGPSSAPSAYPGAPQVP 218
Cdd:PHA03247 2661 VSRPRRARRLGRAAQASSP-PQRPRRRAARPTVGSLTSLadpppppptpEPAPHALVSATPLPPGPAAARQASPALPAAP 2739
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17539780 219 QAPNSfippGTGGFPPGQPTAGSFPPGPQVPGSyPSGPADIPQGPgmPRAFPPGASAPVAP 279
Cdd:PHA03247 2740 APPAV----PAGPATPGGPARPARPPTTAGPPA-PAPPAAPAAGP--PRRLTRPAVASLSE 2793
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
81-280 |
1.39e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 53.02 E-value: 1.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 81 RSTPSAQP-PNPYQPA-----GYPGAPPQQlqqvqrqqtpqqfaAVPQSVQAPSATPAGPLQAMQQAPAPTPGIPQMNQg 154
Cdd:PHA03247 2566 RSVPPPRPaPRPSEPAvtsraRRPDAPPQS--------------ARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPS- 2630
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 155 ahlpPQPHQIHQPTPLRPQIPGFPQAGGSPSSFQAGAPTSQNVQGYPGGPSSAPSAypgaPQVPQAPNSFIPPGTGGFPP 234
Cdd:PHA03247 2631 ----PSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQR----PRRRAARPTVGSLTSLADPP 2702
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 17539780 235 GQPTAGSFPPGPQVPGS-YPSGPAD----IPQGPGMPrAFPPGASAPVAPG 280
Cdd:PHA03247 2703 PPPPTPEPAPHALVSATpLPPGPAAarqaSPALPAAP-APPAVPAGPATPG 2752
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
83-276 |
1.49e-06 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 52.46 E-value: 1.49e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 83 TPSAQPPNPYQPAGYPGAPPQQLQQVQRQQTPQQFAAVPQSV--QAPSATPA---GPLQAMQQAPAPTP-------GIPQ 150
Cdd:pfam03154 189 PGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLiqQTPTLHPQrlpSPHPPLQPMTQPPPpsqvspqPLPQ 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 151 MNQGAHLPPQPHQI-----HQPTPLRPQ-IPGFPQAGGS----PSSFQAGAPTSQNVQGYPGGPSSAPSAYPGAPQVPQA 220
Cdd:pfam03154 269 PSLHGQMPPMPHSLqtgpsHMQHPVPPQpFPLTPQSSQSqvppGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPA 348
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17539780 221 PNSF--IPPGTGGFPPGQPTAGSFPPGPQVPGSYP-SGPADIPQGPG------MPRAFPPGASAP 276
Cdd:pfam03154 349 PLSMphIKPPPTTPIPQLPNPQSHKHPPHLSGPSPfQMNSNLPPPPAlkplssLSTHHPPSAHPP 413
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
79-220 |
2.49e-06 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 51.91 E-value: 2.49e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 79 GARSTPSAQPPNPYQPAGYPGAPPQqlqqvqrqqtpqqfAAVPQSVQAPsATPAGPLQAMQQAPAPTPGIPQMNQGAHLP 158
Cdd:PRK07764 389 GGAGAPAAAAPSAAAAAPAAAPAPA--------------AAAPAAAAAP-APAAAPQPAPAPAPAPAPPSPAGNAPAGGA 453
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17539780 159 PQPHQIHQPTPLrpqipgfPQAGGSPSSFQAGAPTSQNVQGYPGGPSSAPSAYPGAPQVPQA 220
Cdd:PRK07764 454 PSPPPAAAPSAQ-------PAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADD 508
|
|
| PAT1 |
pfam09770 |
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ... |
118-256 |
1.25e-05 |
|
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.
Pssm-ID: 401645 [Multi-domain] Cd Length: 846 Bit Score: 49.65 E-value: 1.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 118 AAVPQSVQA----PSATPAGPLQAMQQAPAPTPGIPQMNQGAHLPPQPHQIHQPtplrPQIPGFPQAGGSPSSFQAGAPT 193
Cdd:pfam09770 209 KPAQQPAPApaqpPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHP----VTILQRPQSPQPDPAQPSIQPQ 284
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17539780 194 SQNVQGYPGGPSSAPSaypgapQVPQAPNSFIPPGTGGFPPGQPTAGSFP--PGPQVPGSYPSGP 256
Cdd:pfam09770 285 AQQFHQQPPPVPVQPT------QILQNPNRLSAARVGYPQNPQPGVQPAPahQAHRQQGSFGRQA 343
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
118-221 |
2.76e-05 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 48.44 E-value: 2.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 118 AAVPQSVQAPSATPAGPLQAMQQAPAPTPGIPQMNQGAhlpPQPHQIHQPTPLRPQIPGFPQAGGSPSSFQAGAPTSQNV 197
Cdd:PRK07764 391 AGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAA---PQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPA 467
|
90 100 110
....*....|....*....|....*....|...
gi 17539780 198 ---------QGYPGGPSSAPSAYPGAPQVPQAP 221
Cdd:PRK07764 468 papaaapepTAAPAPAPPAAPAPAAAPAAPAAP 500
|
|
| PHA03379 |
PHA03379 |
EBNA-3A; Provisional |
120-279 |
3.35e-05 |
|
EBNA-3A; Provisional
Pssm-ID: 223066 [Multi-domain] Cd Length: 935 Bit Score: 48.13 E-value: 3.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 120 VPQSVQapSATPAGPLQAMQQAPAPTPGIPQMNQGAHLPPQPHQIHQPTPLRP-----QIPGFPQAgGSPSSFQAGAPTS 194
Cdd:PHA03379 427 VPQSLE--TATSHGSAQVPEPPPVHDLEPGPLHDQHSMAPCPVAQLPPGPLQDlepgdQLPGVVQD-GRPACAPVPAPAG 503
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 195 QNVQGYPGGPSSAPSAYPgAPQVPQapnsfippgtggfppgqPTAGSFPPGPQVPGSYPSGPAD---IPQGPGMP----R 267
Cdd:PHA03379 504 PIVRPWEASLSQVPGVAF-APVMPQ-----------------PMPVEPVPVPTVALERPVCPAPpliAMQGPGETsgivR 565
|
170
....*....|..
gi 17539780 268 AFPPGASAPVAP 279
Cdd:PHA03379 566 VRERWRPAPWTP 577
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
43-221 |
3.37e-05 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 48.14 E-value: 3.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 43 PGGFPPPHQQPNGQyqngglngnsshlaqsvnnmSIGARSTPSAQPPNPYQPAgyPGAPPQQLQQVQRQQTPQQFAAVPQ 122
Cdd:PHA03378 645 VLVFPTPHQPPQVE--------------------ITPYKPTWTQIGHIPYQPS--PTGANTMLPIQWAPGTMQPPPRAPT 702
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 123 SVQAPSATPaGPLQAMQQAPAPTPGiPQMNQGAHLPPQ----PHQIHQPTPLRPQIPGFPQAGGSPSSFQAGAPTSQNVQ 198
Cdd:PHA03378 703 PMRPPAAPP-GRAQRPAAATGRARP-PAAAPGRARPPAaapgRARPPAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPP 780
|
170 180
....*....|....*....|...
gi 17539780 199 GYPGGPSSAPSAYPGAPQVPQAP 221
Cdd:PHA03378 781 QAPPAPQQRPRGAPTPQPPPQAG 803
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
118-280 |
1.52e-04 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 46.02 E-value: 1.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 118 AAVPQSVQAPSATPAGPLQAMQQAPAPTPGIPQMnqgahlPPQPHQIHQPTPLRPQIPGFPqaggSPSSfQAGAPTSQNV 197
Cdd:PRK12323 372 AGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAA------PAAAPAAAAAARAVAAAPARR----SPAP-EALAAARQAS 440
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 198 QGYPGGPSSAPSAYPGAPqVPQAPNSfippgTGGFPPGQPTAGSFPPGPQVPGSYPSGPADIPQGPGMPRAFPPGASAPV 277
Cdd:PRK12323 441 ARGPGGAPAPAPAPAAAP-AAAARPA-----AAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQP 514
|
...
gi 17539780 278 APG 280
Cdd:PRK12323 515 DAA 517
|
|
| PAT1 |
pfam09770 |
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ... |
47-209 |
1.63e-04 |
|
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.
Pssm-ID: 401645 [Multi-domain] Cd Length: 846 Bit Score: 45.80 E-value: 1.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 47 PPPHQQPNGQYQNGGLNGNSSHLAQSVNNMSIGARSTPSAQPPNPYQPAGYPGAPPQQLQQvqrqqtpqqfaavPQSVQA 126
Cdd:pfam09770 208 KKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVTILQR-------------PQSPQP 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 127 PSATPAGPLQAMQQAPAPTPgipqmnqgahLPPQPHQIHQ----PTPLRPQIPGFPQAGGSPSSFQAGAPtSQNVQGYPG 202
Cdd:pfam09770 275 DPAQPSIQPQAQQFHQQPPP----------VPVQPTQILQnpnrLSAARVGYPQNPQPGVQPAPAHQAHR-QQGSFGRQA 343
|
....*..
gi 17539780 203 GPSSAPS 209
Cdd:pfam09770 344 PIITHPQ 350
|
|
| Glutenin_hmw |
pfam03157 |
High molecular weight glutenin subunit; Members of this family include high molecular weight ... |
43-271 |
2.38e-04 |
|
High molecular weight glutenin subunit; Members of this family include high molecular weight subunits of glutenin. This group of gluten proteins is thought to be largely responsible for the elastic properties of gluten, and hence, doughs. Indeed, glutenin high molecular weight subunits are classified as elastomeric proteins, because the glutenin network can withstand significant deformations without breaking, and return to the original conformation when the stress is removed. Elastomeric proteins differ considerably in amino acid sequence, but they are all polymers whose subunits consist of elastomeric domains, composed of repeated motifs, and non-elastic domains that mediate cross-linking between the subunits. The elastomeric domain motifs are all rich in glycine residues in addition to other hydrophobic residues. High molecular weight glutenin subunits have an extensive central elastomeric domain, flanked by two terminal non-elastic domains that form disulphide cross-links. The central elastomeric domain is characterized by the following three repeated motifs: PGQGQQ, GYYPTS[P/L]QQ, GQQ. It possesses overlapping beta-turns within and between the repeated motifs, and assumes a regular helical secondary structure with a diameter of approx. 1.9 nm and a pitch of approx. 1.5 nm.
Pssm-ID: 367362 [Multi-domain] Cd Length: 786 Bit Score: 45.32 E-value: 2.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 43 PGGFPPPHQQPnGQYQNGGLNGNSSHLAQSvnnmsigarSTPSAQPPNPYQPAGYPGAPPQQLQQvqrqqtpqqfaavPQ 122
Cdd:pfam03157 352 PGYYPTSPQQP-GQGQPGYYPTSQQQPQQG---------QQPEQGQQGQQQGQGQQGQQPGQGQQ-------------PG 408
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 123 SVQaPSATPAGPLQAMQQAPAPTPGIPQMNQGAHLPPQPHQIHQPTPLRPQIPGFPQAGGSPSSFQAGAPTSQNVQGYpg 202
Cdd:pfam03157 409 QGQ-PGYYPTSPQQSGQGQPGYYPTSPQQSGQGQQPGQGQQPGQEQPGQGQQPGQGQQGQQPGQPEQGQQPGQGQPGY-- 485
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 203 gpssapsaYPGAPQVP-QAPNSFIPPGTGGFPPGQPTAGSFPPGPQVPGSYPSGPADIPQGPGMPRAFPP 271
Cdd:pfam03157 486 --------YPTSPQQSgQGQQLGQWQQQGQGQPGYYPTSPLQPGQGQPGYYPTSPQQPGQGQQLGQLQQP 547
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
122-270 |
6.56e-04 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 43.99 E-value: 6.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 122 QSVQAPSATPAGPLQAMQQAPAPTPGIPQmnqgahLPPqphqihQPTPLRPQIPGFPQAGGSPSSFQAGAPTSQnvqgyp 201
Cdd:pfam03154 177 QSGAASPPSPPPPGTTQAATAGPTPSAPS------VPP------QGSPATSQPPNQTQSTAAPHTLIQQTPTLH------ 238
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17539780 202 ggPSSAPSAYPGAPQVPQAPnsfipPGTGGFPPGQPTAGSFPPGPQVPGSYPSGPADIPQgPGMPRAFP 270
Cdd:pfam03154 239 --PQRLPSPHPPLQPMTQPP-----PPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQH-PVPPQPFP 299
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
79-223 |
8.69e-04 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 43.44 E-value: 8.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 79 GARSTPSAQPPNPyQPAGYPGAPPQQlqqvqrqqtpqqfAAVPQSVQAPSATPagplqamqqAPAPTPGIPQMNQGAHLP 158
Cdd:PRK07764 401 AAAAAPAAAPAPA-AAAPAAAAAPAP-------------AAAPQPAPAPAPAP---------APPSPAGNAPAGGAPSPP 457
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17539780 159 PQPHQIHQPTPlrpqipgFPQAGGSPSSFQAGAPTsqnvqgypggPSSAPSAYPGAPQVPQAPNS 223
Cdd:PRK07764 458 PAAAPSAQPAP-------APAAAPEPTAAPAPAPP----------AAPAPAAAPAAPAAPAAPAG 505
|
|
| PRK14951 |
PRK14951 |
DNA polymerase III subunits gamma and tau; Provisional |
79-192 |
1.04e-03 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237865 [Multi-domain] Cd Length: 618 Bit Score: 43.16 E-value: 1.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 79 GARSTPSAQPPNPYQPagyPGAPPQQLQQVQRQQTPQQFAAVPQSVQAPSATPAGPLQAMQQAPAPT-PGIPQMNQGAHL 157
Cdd:PRK14951 369 AAEAAAPAEKKTPARP---EAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAaPAAAPAAAPAAV 445
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 17539780 158 PPQPHQIHQPTPLRPQI-------PGFPQAGGSPSSFQAGAP 192
Cdd:PRK14951 446 ALAPAPPAQAAPETVAIpvrvapePAVASAAPAPAAAPAAAR 487
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
57-281 |
1.53e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 42.56 E-value: 1.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 57 YQNGGLNGNSS--HLAQSVNNMSIGARSTPSAQPPNPYQPAGYPGAPPQQLQQVQRQQTPQQ-----FAAVPQSVQAPSA 129
Cdd:PRK12323 363 FRPGQSGGGAGpaTAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPArrspaPEALAAARQASAR 442
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 130 TPAG-PLQAMQQAPAPTPGIPqmnqgahlPPQPhqihqptPLRPQIPGFPQAGGSPSSFQAGAPTSQNVQGYPGGPSSAP 208
Cdd:PRK12323 443 GPGGaPAPAPAPAAAPAAAAR--------PAAA-------GPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFA 507
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17539780 209 SayPGAPQVPQAPNSFIPPGTGGFPPGQPTAgSFPPGPQVPGSYPSGPADIPQGPGMPrAFPPGASAPVAPGM 281
Cdd:PRK12323 508 S--PAPAQPDAAPAGWVAESIPDPATADPDD-AFETLAPAPAAAPAPRAAAATEPVVA-PRPPRASASGLPDM 576
|
|
| Med15 |
pfam09606 |
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ... |
51-360 |
1.63e-03 |
|
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.
Pssm-ID: 312941 [Multi-domain] Cd Length: 732 Bit Score: 42.69 E-value: 1.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 51 QQPNGQYQNGGLNGNSSHLAQSVNNMSIGARSTPSAQ-----PPNPYQPAGY----PGAPPQQLQQVQRQQTPQQFAAVP 121
Cdd:pfam09606 61 QQPQGGQGNGGMGGGQQGMPDPINALQNLAGQGTRPQmmgpmGPGPGGPMGQqmggPGTASNLLASLGRPQMPMGGAGFP 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 122 QSVQ-----APSATPAGPLQAMQQAPAPT-------------PGIPQMNQGAHLPPQ---PHQIHQPTPLRPQIPG---- 176
Cdd:pfam09606 141 SQMSrvgrmQPGGQAGGMMQPSSGQPGSGtpnqmgpnggpgqGQAGGMNGGQQGPMGgqmPPQMGVPGMPGPADAGaqmg 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 177 --FPQAGGSPSSFQAGAPTSQNVQGYPGGPSSAPSAYPGAPQVPQApnsfIPPGTGGFPPGQPTAGSFPPGPQVPGSYPS 254
Cdd:pfam09606 221 qqAQANGGMNPQQMGGAPNQVAMQQQQPQQQGQQSQLGMGINQMQQ----MPQGVGGGAGQGGPGQPMGPPGQQPGAMPN 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 255 --GPADIP-------------QGPGMPRAFPPGASAPVAPG-----MPGAFPPGQGGPGMPGSFPPGAPGPGGPGMPGSF 314
Cdd:pfam09606 297 vmSIGDQNnyqqqqtrqqqqqQGGNHPAAHQQQMNQSVGQGgqvvaLGGLNHLETWNPGNFGGLGANPMQRGQPGMMSSP 376
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 17539780 315 APGAPGPGGPGGYPSGGPGMPGMQGGYPGGPPQQRQQRLDPNMMPS 360
Cdd:pfam09606 377 SPVPGQQVRQVTPNQFMRQSPQPSVPSPQGPGSQPPQSHPGGMIPS 422
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
77-221 |
2.08e-03 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 42.38 E-value: 2.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 77 SIGARSTPSAQPPNPYQPAGYPGAP-PQQLQQVQRQQTPQQFAAVPQSVQAPSATPAGPLQAMQQAPAPTPgiPQMNQGA 155
Cdd:PRK10263 345 PVASVDVPPAQPTVAWQPVPGPQTGePVIAPAPEGYPQQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQP--AQQPYYA 422
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17539780 156 HLPPQPHQIHQPTPLRPQ-IPGFPQAGGSPSSFQAGAPTSQNVQGYPgGPSSAPSAYPGAPQVPQAP 221
Cdd:PRK10263 423 PAPEQPAQQPYYAPAPEQpVAGNAWQAEEQQSTFAPQSTYQTEQTYQ-QPAAQEPLYQQPQPVEQQP 488
|
|
| PHA02030 |
PHA02030 |
hypothetical protein |
131-221 |
2.17e-03 |
|
hypothetical protein
Pssm-ID: 222843 [Multi-domain] Cd Length: 336 Bit Score: 41.50 E-value: 2.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 131 PAGPLQAMQQAPAPTPGIPQMNQGAHLPPQPHQIhQPTPLRPQIPGFPQAGGSPSSFQAGAPTSQNVQGYPGGPSSAPSA 210
Cdd:PHA02030 239 PGSALHILLGGGEDLIIKPKSKAAGSNLPAVPNV-AADAGSAAAPAVPAAAAAVAQAAPSVPQVPNVAVLPDVPQVAPVA 317
|
90
....*....|.
gi 17539780 211 YPGAPQVPQAP 221
Cdd:PHA02030 318 APAAPEVPAVP 328
|
|
| gelsolin_S3_like |
cd11292 |
Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins; ... |
1003-1033 |
2.36e-03 |
|
Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins; Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin-like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.
Pssm-ID: 200448 Cd Length: 98 Bit Score: 38.38 E-value: 2.36e-03
10 20 30
....*....|....*....|....*....|.
gi 17539780 1003 ASSEFLENSKAYIIDNGVILFVWVGSACPQT 1033
Cdd:cd11292 26 LNQEMLDSEDCYILDCGSEIFVWVGKGASLD 56
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
88-198 |
6.80e-03 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 40.84 E-value: 6.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 88 PPNP-YQPAGYPGAPPQQLQQVQRQQTPQQFAAVPQSVQAPSATPAGPLQAMQQAPAPTPGIPQMNQgahlpPQPHQIHQ 166
Cdd:PRK10263 740 PHEPlFTPIVEPVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQ-----PQQPVAPQ 814
|
90 100 110
....*....|....*....|....*....|..
gi 17539780 167 PTPLRPQIPGFPQaggsPSSFQAGAPTSQNVQ 198
Cdd:PRK10263 815 PQYQQPQQPVAPQ----PQYQQPQQPVAPQPQ 842
|
|
| MISS |
pfam15822 |
MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic ... |
47-267 |
7.56e-03 |
|
MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic MAPK-interacting and spindle-stabilising protein-like proteins. MISS is rich in prolines and has four potential MAPK-phosphorylation sites, a MAPK-docking site, a PEST sequence (PEST motif) and a bipartite nuclear localization signal. The endogenous protein accumulates during mouse meiotic maturation and is found as discrete dots on the MII spindle. MISS is the first example of a physiological MAPK-substrate that is stabilized in MII that specifically regulates MII spindle integrity during the CSF arrest.
Pssm-ID: 318115 [Multi-domain] Cd Length: 238 Bit Score: 39.58 E-value: 7.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 47 PPPHQQPNGQyqnGGLNGNSSHLAQSVNNMSIGARSTPSAQPPNPYQPAGYPGAPPQQLQQVQRQQTPQQFAAVPQsvqa 126
Cdd:pfam15822 21 PKPGQPPQGW---PGSNPWNNPSAPPAVPSGLPPSTAPSTVPFGPAPTGMYPSIPLTGPSPGPPAPFPPSGPSCPP---- 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 127 psatPAGPLQAmQQAPAPTPGIPQMNQGAHLPPQPHQIHQPTplRPQIPGFPQAGGSPSSfQAGAPTSQNVQGYPGGPSS 206
Cdd:pfam15822 94 ----PGGPYPA-PTVPGPGPIGPYPTPNMPFPELPRPYGAPT--DPAAAAPSGPWGSMSS-GPWAPGMGGQYPAPNMPYP 165
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17539780 207 APSAYP---------GAPQVPQA---PNSFIPPGTGGFPPGQPTAGSFPPGPQVPGSYPSGPADIPQGPGMPR 267
Cdd:pfam15822 166 SPGPYPavpppqspgAAPPVPWGtvpPGPWGPPAPYPDPTGSYPMPGLYPTPNNPFQVPSGPSGAPPMPGGPH 238
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
178-279 |
8.39e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 40.35 E-value: 8.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539780 178 PQAGGSPSSFQAGAPTSqnVQGYPGGPSSAPSAYPGAPQVPQAPNSFIPPGTGGFPPGQPTAGSFPPGPQVPGSYPSGPA 257
Cdd:PRK07764 394 PAAAAPSAAAAAPAAAP--APAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPA 471
|
90 100
....*....|....*....|..
gi 17539780 258 DIPQGPGMPRAFPPGASAPVAP 279
Cdd:PRK07764 472 AAPEPTAAPAPAPPAAPAPAAA 493
|
|
| |
