NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|17538216|ref|NP_502128|]
View 

putative prefoldin subunit 4 [Caenorhabditis elegans]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Prefoldin_4 cd23165
prefoldin subunit 4; Prefoldin subunit 4 is one of the beta subunits of the eukaryotic ...
 11-115 3.46e-28

prefoldin subunit 4; Prefoldin subunit 4 is one of the beta subunits of the eukaryotic prefoldin complex. Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes there two or more paralogous genes encoding each subunit adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils.


:

Pssm-ID: 467481 [Multi-domain]  Cd Length: 103  Bit Score: 99.16  E-value: 3.46e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538216  11 DQALLNKFARSYQTQTQLKADVKEAKTLIDNINEASDEILLLDDEDSasIPCRIGSCFVHFNGDSLNEHLEGKKTTAEKV 90
Cdd:cd23165   1 DQQKINKFSRLNARLHELKEELKAKKKELENLEDASDELELADDDEP--VPYKIGEVFVHLSLEEAQERLEKAKEELEEE 78

                        90       100
                ....*....|....*....|....*
gi 17538216  91 LSEKTSELDAISADMEQIKKVLYAK 115
Cdd:cd23165  79 IEKLEEEIDEIEEEMKELKVQLYAK 103
 
Name Accession Description Interval E-value
Prefoldin_4 cd23165
prefoldin subunit 4; Prefoldin subunit 4 is one of the beta subunits of the eukaryotic ...
 11-115 3.46e-28

prefoldin subunit 4; Prefoldin subunit 4 is one of the beta subunits of the eukaryotic prefoldin complex. Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes there two or more paralogous genes encoding each subunit adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils.


Pssm-ID: 467481 [Multi-domain]  Cd Length: 103  Bit Score: 99.16  E-value: 3.46e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538216  11 DQALLNKFARSYQTQTQLKADVKEAKTLIDNINEASDEILLLDDEDSasIPCRIGSCFVHFNGDSLNEHLEGKKTTAEKV 90
Cdd:cd23165   1 DQQKINKFSRLNARLHELKEELKAKKKELENLEDASDELELADDDEP--VPYKIGEVFVHLSLEEAQERLEKAKEELEEE 78

                        90       100
                ....*....|....*....|....*
gi 17538216  91 LSEKTSELDAISADMEQIKKVLYAK 115
Cdd:cd23165  79 IEKLEEEIDEIEEEMKELKVQLYAK 103
Prefoldin_2 pfam01920
Prefoldin subunit; This family includes prefoldin subunits that are not detected by pfam02996.
 15-118 7.80e-17

Prefoldin subunit; This family includes prefoldin subunits that are not detected by pfam02996.


Pssm-ID: 396482 [Multi-domain]  Cd Length: 102  Bit Score: 69.94  E-value: 7.80e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538216    15 LNKFARSYQTQTQLKADVKEAKTLIDNINEASDEILLLDDEdsASIPCRIGSCFVHFNGDSLNEHLEGKKTTAEKVLSEK 94
Cdd:pfam01920   1 INKFQQLQQQLQLLAQQIKQLETQLKELELALEELELLDED--TKVYKLIGDVLVKQDKEEVKEQLEERKETLEKEIKTL 78

                          90       100
                  ....*....|....*....|....
gi 17538216    95 TSELDAISADMEQIKKVLYAKFGD 118
Cdd:pfam01920  79 EKQLEKLEKELEELKEELYKKFGQ 102
 
Name Accession Description Interval E-value
Prefoldin_4 cd23165
prefoldin subunit 4; Prefoldin subunit 4 is one of the beta subunits of the eukaryotic ...
 11-115 3.46e-28

prefoldin subunit 4; Prefoldin subunit 4 is one of the beta subunits of the eukaryotic prefoldin complex. Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes there two or more paralogous genes encoding each subunit adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils.


Pssm-ID: 467481 [Multi-domain]  Cd Length: 103  Bit Score: 99.16  E-value: 3.46e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538216  11 DQALLNKFARSYQTQTQLKADVKEAKTLIDNINEASDEILLLDDEDSasIPCRIGSCFVHFNGDSLNEHLEGKKTTAEKV 90
Cdd:cd23165   1 DQQKINKFSRLNARLHELKEELKAKKKELENLEDASDELELADDDEP--VPYKIGEVFVHLSLEEAQERLEKAKEELEEE 78

                        90       100
                ....*....|....*....|....*
gi 17538216  91 LSEKTSELDAISADMEQIKKVLYAK 115
Cdd:cd23165  79 IEKLEEEIDEIEEEMKELKVQLYAK 103
Prefoldin_2 pfam01920
Prefoldin subunit; This family includes prefoldin subunits that are not detected by pfam02996.
 15-118 7.80e-17

Prefoldin subunit; This family includes prefoldin subunits that are not detected by pfam02996.


Pssm-ID: 396482 [Multi-domain]  Cd Length: 102  Bit Score: 69.94  E-value: 7.80e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538216    15 LNKFARSYQTQTQLKADVKEAKTLIDNINEASDEILLLDDEdsASIPCRIGSCFVHFNGDSLNEHLEGKKTTAEKVLSEK 94
Cdd:pfam01920   1 INKFQQLQQQLQLLAQQIKQLETQLKELELALEELELLDED--TKVYKLIGDVLVKQDKEEVKEQLEERKETLEKEIKTL 78

                          90       100
                  ....*....|....*....|....
gi 17538216    95 TSELDAISADMEQIKKVLYAKFGD 118
Cdd:pfam01920  79 EKQLEKLEKELEELKEELYKKFGQ 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH