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Conserved domains on  [gi|17544064|ref|NP_502042|]
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Phosphatidylethanolamine-binding protein [Caenorhabditis elegans]

Protein Classification

YbhB/YbcL family Raf kinase inhibitor-like protein( domain architecture ID 10096268)

YbhB/YbcL family Raf kinase inhibitor-like protein similar to mammalian phosphatidylethanolamine-binding protein 1/2 and Schizosaccharomyces pombe mitochondrial 54S ribosomal protein L35

CATH:  3.90.280.10
SCOP:  4002457

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PEBP_euk cd00866
PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; ...
 25-168 1.13e-45

PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). The members in this subgroup are present in eukaryotes. Members here include those in plants such as Arabidopsis thaliana FLOWERING LOCUS (FT) and TERMINAL FLOWER1 (FT1) which function as a promoter and a repressor of the floral transitions, respectively as well as the mammalian Raf kinase inhibitory protein (RKIP) which inhibits MAP kinase (Raf-MEK-ERK), G protein-coupled receptor (GPCR) kinase and NFkappaB signaling cascades. Although their overall structures are similar, the members of the PEBP family have very different substrates and oligomerization states (monomer/dimer/tetramer).


:

Pssm-ID: 176644 [Multi-domain]  Cd Length: 154  Bit Score: 147.13  E-value: 1.13e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544064  25 KLHLCWDGIQ-VEPGMTMQVRNLKNAPRWALPGAD-PESIYTVLMIDPDNLSRKNPSVAEWLHWLVCNIPASNIIDG-IN 101
Cdd:cd00866   2 DLTVSYGSSGvVTPGNLLTPSETQKAPTVSFSSEDpPDKLYTLVMVDPDAPSRDDPKFREWLHWLVTNIPGSDTTTGlVS 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17544064 102 GGQHQMAYGSPAPGPRTDLHRYVILMWEHAGRRISVPK------PSSRAKFNVKQFIEKNKLGDPIAGNFFLA 168
Cdd:cd00866  82 KGEVLVPYLGPGPPKGTGPHRYVFLLFKQPGGLDFPESklpptsGLGRRGFDVREFAKKNGLGLPVAANFFQV 154
 
Name Accession Description Interval E-value
PEBP_euk cd00866
PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; ...
 25-168 1.13e-45

PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). The members in this subgroup are present in eukaryotes. Members here include those in plants such as Arabidopsis thaliana FLOWERING LOCUS (FT) and TERMINAL FLOWER1 (FT1) which function as a promoter and a repressor of the floral transitions, respectively as well as the mammalian Raf kinase inhibitory protein (RKIP) which inhibits MAP kinase (Raf-MEK-ERK), G protein-coupled receptor (GPCR) kinase and NFkappaB signaling cascades. Although their overall structures are similar, the members of the PEBP family have very different substrates and oligomerization states (monomer/dimer/tetramer).


Pssm-ID: 176644 [Multi-domain]  Cd Length: 154  Bit Score: 147.13  E-value: 1.13e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544064  25 KLHLCWDGIQ-VEPGMTMQVRNLKNAPRWALPGAD-PESIYTVLMIDPDNLSRKNPSVAEWLHWLVCNIPASNIIDG-IN 101
Cdd:cd00866   2 DLTVSYGSSGvVTPGNLLTPSETQKAPTVSFSSEDpPDKLYTLVMVDPDAPSRDDPKFREWLHWLVTNIPGSDTTTGlVS 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17544064 102 GGQHQMAYGSPAPGPRTDLHRYVILMWEHAGRRISVPK------PSSRAKFNVKQFIEKNKLGDPIAGNFFLA 168
Cdd:cd00866  82 KGEVLVPYLGPGPPKGTGPHRYVFLLFKQPGGLDFPESklpptsGLGRRGFDVREFAKKNGLGLPVAANFFQV 154
PLN00169 PLN00169
CETS family protein; Provisional
 34-172 5.11e-27

CETS family protein; Provisional


Pssm-ID: 177765  Cd Length: 175  Bit Score: 99.88  E-value: 5.11e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544064   34 QVEPGMTMQVRNLKNAPRWALPGADPESIYTVLMIDPDNLSRKNPSVAEWLHWLVCNIPASNiidGINGGQHQMAYGSPA 113
Cdd:PLN00169  36 EVNNGCELKPSQVVNQPRVDIGGEDLRTFYTLVMVDPDAPSPSNPNLREYLHWLVTDIPATT---GATFGQEVVCYESPR 112

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 17544064  114 pgPRTDLHRYVILMWEHAGRRiSVPKPSSRAKFNVKQFIEKNKLGDPIAGNFFLAQHEG 172
Cdd:PLN00169 113 --PTAGIHRFVFVLFRQLGRQ-TVYAPGWRQNFNTRDFAELYNLGSPVAAVYFNCQRES 168
PBP pfam01161
Phosphatidylethanolamine-binding protein;
63-165 2.81e-16

Phosphatidylethanolamine-binding protein;


Pssm-ID: 460090  Cd Length: 136  Bit Score: 71.22  E-value: 2.81e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544064    63 YTVLMIDPDNlsrknPSVAE--WLHWLVCNIPASN----------IIDGINGGQhQMAYGSPAPGPRTDLHRYVILMWeh 130
Cdd:pfam01161  29 FALVMIDPDA-----PKVGGsgWLHWVVTNIPATVtelpegapagAVQGLNDFG-GAGYGGPCPPAGDGPHRYVFTLY-- 100

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 17544064   131 agrRISVPKPSSRAKFNVKQF---IEKNKLGD-PIAGNF 165
Cdd:pfam01161 101 ---ALDVPLLDRNWGFTKAELgvaFAGHVLALaVLAGNY 136
PEBP COG1881
Uncharacterized conserved protein, phosphatidylethanolamine-binding protein (PEBP) family ...
 63-125 3.56e-07

Uncharacterized conserved protein, phosphatidylethanolamine-binding protein (PEBP) family [General function prediction only];


Pssm-ID: 441485  Cd Length: 151  Bit Score: 47.07  E-value: 3.56e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17544064  63 YTVLMIDPDNlsrknPSVAEWLHWLVCNIPAS---------------NIIDGINGGqHQMAYGSPAPGPRTDLHRYVI 125
Cdd:COG1881  41 FALIVEDPDA-----PTGGGFWHWVVYNIPADvtelpegagsadlpaGAVQGRNDF-GEAGYGGPCPPPGDGPHRYVF 112
TIGR00481 TIGR00481
Raf kinase inhibitor-like protein, YbhB/YbcL family; [Unknown function, General]
 63-158 4.49e-04

Raf kinase inhibitor-like protein, YbhB/YbcL family; [Unknown function, General]


Pssm-ID: 129572  Cd Length: 141  Bit Score: 38.62  E-value: 4.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544064    63 YTVLMIDPDNlsrknPSVAEWLHWLVCNIPASN-------------IIDG--ING----GQHQmaYGSPAPgPRTDlHRY 123
Cdd:TIGR00481  30 LALTCIDPDA-----PTGCGWWHWVVVNIPADTtvlpenassddkrLPQGvpLQGrndfGKSG--YIGPCP-PKGD-HRY 100

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 17544064   124 VILMWEHAGRRISVPKPSSRAkfNVKQFIEKNKLG 158
Cdd:TIGR00481 101 LFTVYALDTEKLDLDPGFSLA--DLGDAMEGHILA 133
 
Name Accession Description Interval E-value
PEBP_euk cd00866
PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; ...
 25-168 1.13e-45

PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). The members in this subgroup are present in eukaryotes. Members here include those in plants such as Arabidopsis thaliana FLOWERING LOCUS (FT) and TERMINAL FLOWER1 (FT1) which function as a promoter and a repressor of the floral transitions, respectively as well as the mammalian Raf kinase inhibitory protein (RKIP) which inhibits MAP kinase (Raf-MEK-ERK), G protein-coupled receptor (GPCR) kinase and NFkappaB signaling cascades. Although their overall structures are similar, the members of the PEBP family have very different substrates and oligomerization states (monomer/dimer/tetramer).


Pssm-ID: 176644 [Multi-domain]  Cd Length: 154  Bit Score: 147.13  E-value: 1.13e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544064  25 KLHLCWDGIQ-VEPGMTMQVRNLKNAPRWALPGAD-PESIYTVLMIDPDNLSRKNPSVAEWLHWLVCNIPASNIIDG-IN 101
Cdd:cd00866   2 DLTVSYGSSGvVTPGNLLTPSETQKAPTVSFSSEDpPDKLYTLVMVDPDAPSRDDPKFREWLHWLVTNIPGSDTTTGlVS 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17544064 102 GGQHQMAYGSPAPGPRTDLHRYVILMWEHAGRRISVPK------PSSRAKFNVKQFIEKNKLGDPIAGNFFLA 168
Cdd:cd00866  82 KGEVLVPYLGPGPPKGTGPHRYVFLLFKQPGGLDFPESklpptsGLGRRGFDVREFAKKNGLGLPVAANFFQV 154
PLN00169 PLN00169
CETS family protein; Provisional
 34-172 5.11e-27

CETS family protein; Provisional


Pssm-ID: 177765  Cd Length: 175  Bit Score: 99.88  E-value: 5.11e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544064   34 QVEPGMTMQVRNLKNAPRWALPGADPESIYTVLMIDPDNLSRKNPSVAEWLHWLVCNIPASNiidGINGGQHQMAYGSPA 113
Cdd:PLN00169  36 EVNNGCELKPSQVVNQPRVDIGGEDLRTFYTLVMVDPDAPSPSNPNLREYLHWLVTDIPATT---GATFGQEVVCYESPR 112

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 17544064  114 pgPRTDLHRYVILMWEHAGRRiSVPKPSSRAKFNVKQFIEKNKLGDPIAGNFFLAQHEG 172
Cdd:PLN00169 113 --PTAGIHRFVFVLFRQLGRQ-TVYAPGWRQNFNTRDFAELYNLGSPVAAVYFNCQRES 168
PBP pfam01161
Phosphatidylethanolamine-binding protein;
63-165 2.81e-16

Phosphatidylethanolamine-binding protein;


Pssm-ID: 460090  Cd Length: 136  Bit Score: 71.22  E-value: 2.81e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544064    63 YTVLMIDPDNlsrknPSVAE--WLHWLVCNIPASN----------IIDGINGGQhQMAYGSPAPGPRTDLHRYVILMWeh 130
Cdd:pfam01161  29 FALVMIDPDA-----PKVGGsgWLHWVVTNIPATVtelpegapagAVQGLNDFG-GAGYGGPCPPAGDGPHRYVFTLY-- 100

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 17544064   131 agrRISVPKPSSRAKFNVKQF---IEKNKLGD-PIAGNF 165
Cdd:pfam01161 101 ---ALDVPLLDRNWGFTKAELgvaFAGHVLALaVLAGNY 136
PEBP cd00457
PhosphatidylEthanolamine-Binding Protein (PEBP) domain; PhosphatidylEthanolamine-Binding ...
 50-168 1.75e-14

PhosphatidylEthanolamine-Binding Protein (PEBP) domain; PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). A number of biological roles for members of the PEBP family include serine protease inhibition, membrane biogenesis, regulation of flowering plant stem architecture, and Raf-1 kinase inhibition. Although their overall structures are similar, the members of the PEBP family bind very different substrates including phospholipids, opioids, and hydrophobic odorant molecules as well as having different oligomerization states (monomer/dimer/tetramer).


Pssm-ID: 176642  Cd Length: 159  Bit Score: 67.04  E-value: 1.75e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544064  50 PRWALPGADPE-SIYTVLMIDPDNlsrknPSVAEWLHWLVCNIPASNIID-------------GINGG------QHQMAY 109
Cdd:cd00457  27 PSLSWDGPPPDvKEYVLVMEDPDA-----PLGRPIVHGLVYGIPANKTSLsnddfvvtdngkgGLQGGfkygknRGGTVY 101

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 17544064 110 GSPAPGPRTDLHRYVILMWEHAGRRISVPKPSSRAKFNVKQFIEKNKLGdPIAGNFFLA 168
Cdd:cd00457 102 IGPRPPLGHGPHRYFFQVYALDEPLDRSKLGDGRTKFEVARFAEGNVLG-AVGEWVGQF 159
PEBP COG1881
Uncharacterized conserved protein, phosphatidylethanolamine-binding protein (PEBP) family ...
 63-125 3.56e-07

Uncharacterized conserved protein, phosphatidylethanolamine-binding protein (PEBP) family [General function prediction only];


Pssm-ID: 441485  Cd Length: 151  Bit Score: 47.07  E-value: 3.56e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17544064  63 YTVLMIDPDNlsrknPSVAEWLHWLVCNIPAS---------------NIIDGINGGqHQMAYGSPAPGPRTDLHRYVI 125
Cdd:COG1881  41 FALIVEDPDA-----PTGGGFWHWVVYNIPADvtelpegagsadlpaGAVQGRNDF-GEAGYGGPCPPPGDGPHRYVF 112
PRK10257 PRK10257
putative kinase inhibitor protein; Provisional
 34-148 1.84e-05

putative kinase inhibitor protein; Provisional


Pssm-ID: 182339  Cd Length: 158  Bit Score: 42.84  E-value: 1.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544064   34 QVEPGMTMQVRNLKNAPRWALPGADPESiYTVLMIDPDNlsrknPSVAEWLHWLVCNIPASN--IIDGINGGQHQM---- 107
Cdd:PRK10257  18 HVFNGMGYDGDNISPHLAWDDVPAGTKS-FVVTCYDPDA-----PTGSGWWHWVVVNLPADTrvLPQGFGSGLVALpdgv 91

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 17544064  108 ----------AYGSPAPgPRTDLHRYVILMWEHAGRRISVPKPSSRA--KFNV 148
Cdd:PRK10257  92 lqtrtdfgkaGYGGAAP-PKGETHRYIFTVHALDVERIDVDEGASGAmvGFNV 143
PEBP_bact_arch cd00865
PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; ...
 51-125 4.92e-05

PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). The members in this subgroup are present in bacterial and archaea. Members here include Escherichia coli YBHB and YBCL which are thought to regulate protein phosphorylation as well as Sulfolobus solfataricus SsCEI which inhibits serine proteases alpha-chymotrypsin and elastase. Although their overall structures are similar, the members of the PEBP family have very different substrates and oligomerization states (monomer/dimer/tetramer). In a few of the bacterial members present here the dimerization interface is proposed to form the ligand binding site, unlike in other PEBP members.


Pssm-ID: 176643  Cd Length: 150  Bit Score: 41.43  E-value: 4.92e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544064  51 RWALPGADPESiYTVLMIDPDNlsrknPSVAEWLHWLVCNIPAS---------------NIIDGINGGQHQmAYGSPAPg 115
Cdd:cd00865  31 SWSGVPAGTKS-LALIVEDPDA-----PTGGGFVHWVVWNIPADttelpegasrgalpaGAVQGRNDFGEA-GYGGPCP- 102

                        90
                ....*....|
gi 17544064 116 PRTDLHRYVI 125
Cdd:cd00865 103 PDGGPHRYVF 112
TIGR00481 TIGR00481
Raf kinase inhibitor-like protein, YbhB/YbcL family; [Unknown function, General]
 63-158 4.49e-04

Raf kinase inhibitor-like protein, YbhB/YbcL family; [Unknown function, General]


Pssm-ID: 129572  Cd Length: 141  Bit Score: 38.62  E-value: 4.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544064    63 YTVLMIDPDNlsrknPSVAEWLHWLVCNIPASN-------------IIDG--ING----GQHQmaYGSPAPgPRTDlHRY 123
Cdd:TIGR00481  30 LALTCIDPDA-----PTGCGWWHWVVVNIPADTtvlpenassddkrLPQGvpLQGrndfGKSG--YIGPCP-PKGD-HRY 100

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 17544064   124 VILMWEHAGRRISVPKPSSRAkfNVKQFIEKNKLG 158
Cdd:TIGR00481 101 LFTVYALDTEKLDLDPGFSLA--DLGDAMEGHILA 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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