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Conserved domains on  [gi|25150462|ref|NP_501968|]
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Flavin-containing monooxygenase [Caenorhabditis elegans]

Protein Classification

flavin-binding monooxygenase-like family protein( domain architecture ID 1000557)

flavin-binding monooxygenase-like family protein; such as flavin-containing monooxygenases (FMOs) that catalyze the monooxygenation of a variety of substrates

EC:  1.14.13.-
Gene Ontology:  GO:0004497

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FMO-like super family cl30939
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ...
 6-533 0e+00

Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.


The actual alignment was detected with superfamily member pfam00743:

Pssm-ID: 395602 [Multi-domain]  Cd Length: 531  Bit Score: 554.00  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462     6 KKLLIVGAGASGLPSLRHALLYGIDVTCFERTKDVGGLWHYKPQETE-LSSVMKTTVINTSKEMTAYSDFPPESRMANFM 84
Cdd:pfam00743   2 KKVAVIGAGVSGLASIKCCLEEGLEPTCFERSDDIGGLWRFTENVEEgRASIYKSVITNTSKEMSCFSDFPFPEDYPNFM 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462    85 HNTEMYRYLLNYSKHYELEKHIKFNHKVNSIDRNEDYEKTGKWKVnYTDDKGATHDAVFDGVMLCSGHHTTPNWP-QKFR 163
Cdd:pfam00743  82 HNSKFLEYFRMFAKEFDLLKYIQFKTTVCSVKKRPDFSTSGQWEV-VTEHEGKQESAVFDAVMVCTGHHTNPHLPlESFP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462   164 GQDDFKGRIIHSHSYKDHRGYEDKVVVVVGIGNSGGDVAVELSRIAKQVYLVTRRGTWVFNRIYDYGQPIDIAMNRKCIS 243
Cdd:pfam00743 161 GIEKFKGQYFHSRDYKHPEGFTGKRVLVIGIGNSGGDIAVELSHTAAQVFLSTRRGSWVLSRVSDHGYPWDMLFSTRFTS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462   244 DLRSFVPAWLTNTVVEAKLNQRFDHQAYGLKPSHRVFGAHPTVNDELPNRIACGTVRIKPNISKFTETGVLFEDGSLIEQ 323
Cdd:pfam00743 241 FLRNILPTSISNWLMEKQMNRRFNHENYGLKPKNRALSKEPVVNDDLPNRILCGAVKVKPNVKEFTETSAIFEDGTVEED 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462   324 VDEIVMSTGFSFEFNLVENgQLIRTHDNQVSLYQYMFPIELgDHNSLAVIGLVQPFGSIMPLSEMQARVYLEEFTGNHVL 403
Cdd:pfam00743 321 IDVVIFATGYTFAFPFLEE-SLVKVENNKVSLYKYVFPPNL-EKPTLAIIGLIQPLGSIIPTVELQARWATRVFKGLCTL 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462   404 PKKNEMTQNVHDKLETMARRYVTSRRHTIQVDYVDYIEELAKMIGADLDMKKLWKEDPWLAYKVYFGPCVPYIYRLKGPH 483
Cdd:pfam00743 399 PSQSEMMAEINKRQEKKIKRFGDSQSHTIQTDYIDYMDELALFIGAKPNLLSLLLTDPKLALKLFFGPCTPYQYRLVGPG 478

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|.
gi 25150462   484 KWNNARDAIMSVDERVLMATNDHA-QVAPDYTLLYIVGlIFAIIAVFYILF 533
Cdd:pfam00743 479 KWEGARNAILTQWDRILKPLKTRVvEKSSSPASSFTLK-IFGLPVVLVAIF 528
 
Name Accession Description Interval E-value
FMO-like pfam00743
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ...
 6-533 0e+00

Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.


Pssm-ID: 395602 [Multi-domain]  Cd Length: 531  Bit Score: 554.00  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462     6 KKLLIVGAGASGLPSLRHALLYGIDVTCFERTKDVGGLWHYKPQETE-LSSVMKTTVINTSKEMTAYSDFPPESRMANFM 84
Cdd:pfam00743   2 KKVAVIGAGVSGLASIKCCLEEGLEPTCFERSDDIGGLWRFTENVEEgRASIYKSVITNTSKEMSCFSDFPFPEDYPNFM 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462    85 HNTEMYRYLLNYSKHYELEKHIKFNHKVNSIDRNEDYEKTGKWKVnYTDDKGATHDAVFDGVMLCSGHHTTPNWP-QKFR 163
Cdd:pfam00743  82 HNSKFLEYFRMFAKEFDLLKYIQFKTTVCSVKKRPDFSTSGQWEV-VTEHEGKQESAVFDAVMVCTGHHTNPHLPlESFP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462   164 GQDDFKGRIIHSHSYKDHRGYEDKVVVVVGIGNSGGDVAVELSRIAKQVYLVTRRGTWVFNRIYDYGQPIDIAMNRKCIS 243
Cdd:pfam00743 161 GIEKFKGQYFHSRDYKHPEGFTGKRVLVIGIGNSGGDIAVELSHTAAQVFLSTRRGSWVLSRVSDHGYPWDMLFSTRFTS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462   244 DLRSFVPAWLTNTVVEAKLNQRFDHQAYGLKPSHRVFGAHPTVNDELPNRIACGTVRIKPNISKFTETGVLFEDGSLIEQ 323
Cdd:pfam00743 241 FLRNILPTSISNWLMEKQMNRRFNHENYGLKPKNRALSKEPVVNDDLPNRILCGAVKVKPNVKEFTETSAIFEDGTVEED 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462   324 VDEIVMSTGFSFEFNLVENgQLIRTHDNQVSLYQYMFPIELgDHNSLAVIGLVQPFGSIMPLSEMQARVYLEEFTGNHVL 403
Cdd:pfam00743 321 IDVVIFATGYTFAFPFLEE-SLVKVENNKVSLYKYVFPPNL-EKPTLAIIGLIQPLGSIIPTVELQARWATRVFKGLCTL 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462   404 PKKNEMTQNVHDKLETMARRYVTSRRHTIQVDYVDYIEELAKMIGADLDMKKLWKEDPWLAYKVYFGPCVPYIYRLKGPH 483
Cdd:pfam00743 399 PSQSEMMAEINKRQEKKIKRFGDSQSHTIQTDYIDYMDELALFIGAKPNLLSLLLTDPKLALKLFFGPCTPYQYRLVGPG 478

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|.
gi 25150462   484 KWNNARDAIMSVDERVLMATNDHA-QVAPDYTLLYIVGlIFAIIAVFYILF 533
Cdd:pfam00743 479 KWEGARNAILTQWDRILKPLKTRVvEKSSSPASSFTLK-IFGLPVVLVAIF 528
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 9-391 1.95e-71

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 233.99  E-value: 1.95e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462   9 LIVGAGASGLPSLRHALLYGIDVTCFERTKDVGGLWHYK--PqetelssvmkTTVINTSKEMTAYSDFPPESRMANFMHN 86
Cdd:COG2072  10 VVIGAGQAGLAAAYHLRRAGIDFVVLEKADDVGGTWRDNryP----------GLRLDTPSHLYSLPFFPNWSDDPDFPTG 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462  87 TEMYRYLLNYSKHYELEKHIKFNHKVNSIDRNEDyekTGKWKVnyTDDKGATHDAvfDGVMLCSGHHTTPNWPQkFRGQD 166
Cdd:COG2072  80 DEILAYLEAYADKFGLRRPIRFGTEVTSARWDEA---DGRWTV--TTDDGETLTA--RFVVVATGPLSRPKIPD-IPGLE 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462 167 DFKGRIIHSHSYKDHRGYEDKVVVVVGIGNSGGDVAVELSRIAKQVYLVTRRGTWVFNRiYDY----GQPIDIAMNRKCI 242
Cdd:COG2072 152 DFAGEQLHSADWRNPVDLAGKRVLVVGTGASAVQIAPELARVAAHVTVFQRTPPWVLPR-PNYdperGRPANYLGLEAPP 230

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462 243 SDLRSFVPAWLtntvvEAKLNQRFDHQAYG-LKPSHRVFGAHPTVNDELPNRIACGTVRIK-PNISKFTETGVLFEDGSL 320
Cdd:COG2072 231 ALNRRDARAWL-----RRLLRAQVKDPELGlLTPDYPPGCKRPLLSTDYYEALRRGNVELVtGGIERITEDGVVFADGTE 305

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 25150462 321 IEqVDEIVMSTGFSFEFNLVENGQLI-RTHDNQVSLYQYMFPieLGDHNsLAVIGLVQPFG--SIMPLSEMQAR 391
Cdd:COG2072 306 HE-VDVIVWATGFRADLPWLAPLDVRgRDGRSGPRAYLGVVV--PGFPN-LFFLGPNSPSGhsSLTLGAERQAR 375
PLN02172 PLN02172
flavin-containing monooxygenase FMO GS-OX
 1-443 2.68e-39

flavin-containing monooxygenase FMO GS-OX


Pssm-ID: 215116 [Multi-domain]  Cd Length: 461  Bit Score: 148.86  E-value: 2.68e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462    1 MAP-----NNKKLLIVGAGASGLPSLRHALLYGIDVTCFERTKDVGGLWHYKPQETE------------LSSVMKTTVIN 63
Cdd:PLN02172   1 MAPaqnpiNSQHVAVIGAGAAGLVAARELRREGHTVVVFEREKQVGGLWVYTPKSESdplsldptrsivHSSVYESLRTN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462   64 TSKEMTAYSDFP------PESRMAN-FMHNTEMYRYLLNYSKHYELEKHIKFNHKVNSIDrnedyEKTGKWKVNYTDDKG 136
Cdd:PLN02172  81 LPRECMGYRDFPfvprfdDESRDSRrYPSHREVLAYLQDFAREFKIEEMVRFETEVVRVE-----PVDGKWRVQSKNSGG 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462  137 ATHDAVFDGVMLCSGHHTTPNWPQkFRGQDDFKGRIIHSHSYKDHRGYEDKVVVVVGIGNSGGDVAVELSRIAKQVYLVT 216
Cdd:PLN02172 156 FSKDEIFDAVVVCNGHYTEPNVAH-IPGIKSWPGKQIHSHNYRVPDPFKNEVVVVIGNFASGADISRDIAKVAKEVHIAS 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462  217 RRgtwvfnriydygqpidiamnrkcisdlrsfvpawltntvveaklnqrfdhqayglKPSHrVFGAHPTVNDELpnriac 296
Cdd:PLN02172 235 RA-------------------------------------------------------SESD-TYEKLPVPQNNL------ 252

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462  297 gtvRIKPNISKFTETG-VLFEDGSLIeQVDEIVMSTGFSFEFNLVENGQLIRTHDNQVS-LYQYMFPIELGDhnSLAVIG 374
Cdd:PLN02172 253 ---WMHSEIDTAHEDGsIVFKNGKVV-YADTIVHCTGYKYHFPFLETNGYMRIDENRVEpLYKHVFPPALAP--GLSFIG 326

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 25150462  375 LvQPFGSIMPLSEMQARVYLEEFTGNHVLPKKNEMTQNV---HDKLETMA--RRYvTSRRHTIQVDYVDYIEEL 443
Cdd:PLN02172 327 L-PAMGIQFVMFEIQSKWVAAVLSGRVTLPSEDKMMEDInawYASLEALGipKRY-THKLGKIQSEYLNWIAEE 398
 
Name Accession Description Interval E-value
FMO-like pfam00743
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ...
 6-533 0e+00

Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.


Pssm-ID: 395602 [Multi-domain]  Cd Length: 531  Bit Score: 554.00  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462     6 KKLLIVGAGASGLPSLRHALLYGIDVTCFERTKDVGGLWHYKPQETE-LSSVMKTTVINTSKEMTAYSDFPPESRMANFM 84
Cdd:pfam00743   2 KKVAVIGAGVSGLASIKCCLEEGLEPTCFERSDDIGGLWRFTENVEEgRASIYKSVITNTSKEMSCFSDFPFPEDYPNFM 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462    85 HNTEMYRYLLNYSKHYELEKHIKFNHKVNSIDRNEDYEKTGKWKVnYTDDKGATHDAVFDGVMLCSGHHTTPNWP-QKFR 163
Cdd:pfam00743  82 HNSKFLEYFRMFAKEFDLLKYIQFKTTVCSVKKRPDFSTSGQWEV-VTEHEGKQESAVFDAVMVCTGHHTNPHLPlESFP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462   164 GQDDFKGRIIHSHSYKDHRGYEDKVVVVVGIGNSGGDVAVELSRIAKQVYLVTRRGTWVFNRIYDYGQPIDIAMNRKCIS 243
Cdd:pfam00743 161 GIEKFKGQYFHSRDYKHPEGFTGKRVLVIGIGNSGGDIAVELSHTAAQVFLSTRRGSWVLSRVSDHGYPWDMLFSTRFTS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462   244 DLRSFVPAWLTNTVVEAKLNQRFDHQAYGLKPSHRVFGAHPTVNDELPNRIACGTVRIKPNISKFTETGVLFEDGSLIEQ 323
Cdd:pfam00743 241 FLRNILPTSISNWLMEKQMNRRFNHENYGLKPKNRALSKEPVVNDDLPNRILCGAVKVKPNVKEFTETSAIFEDGTVEED 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462   324 VDEIVMSTGFSFEFNLVENgQLIRTHDNQVSLYQYMFPIELgDHNSLAVIGLVQPFGSIMPLSEMQARVYLEEFTGNHVL 403
Cdd:pfam00743 321 IDVVIFATGYTFAFPFLEE-SLVKVENNKVSLYKYVFPPNL-EKPTLAIIGLIQPLGSIIPTVELQARWATRVFKGLCTL 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462   404 PKKNEMTQNVHDKLETMARRYVTSRRHTIQVDYVDYIEELAKMIGADLDMKKLWKEDPWLAYKVYFGPCVPYIYRLKGPH 483
Cdd:pfam00743 399 PSQSEMMAEINKRQEKKIKRFGDSQSHTIQTDYIDYMDELALFIGAKPNLLSLLLTDPKLALKLFFGPCTPYQYRLVGPG 478

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|.
gi 25150462   484 KWNNARDAIMSVDERVLMATNDHA-QVAPDYTLLYIVGlIFAIIAVFYILF 533
Cdd:pfam00743 479 KWEGARNAILTQWDRILKPLKTRVvEKSSSPASSFTLK-IFGLPVVLVAIF 528
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 9-391 1.95e-71

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 233.99  E-value: 1.95e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462   9 LIVGAGASGLPSLRHALLYGIDVTCFERTKDVGGLWHYK--PqetelssvmkTTVINTSKEMTAYSDFPPESRMANFMHN 86
Cdd:COG2072  10 VVIGAGQAGLAAAYHLRRAGIDFVVLEKADDVGGTWRDNryP----------GLRLDTPSHLYSLPFFPNWSDDPDFPTG 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462  87 TEMYRYLLNYSKHYELEKHIKFNHKVNSIDRNEDyekTGKWKVnyTDDKGATHDAvfDGVMLCSGHHTTPNWPQkFRGQD 166
Cdd:COG2072  80 DEILAYLEAYADKFGLRRPIRFGTEVTSARWDEA---DGRWTV--TTDDGETLTA--RFVVVATGPLSRPKIPD-IPGLE 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462 167 DFKGRIIHSHSYKDHRGYEDKVVVVVGIGNSGGDVAVELSRIAKQVYLVTRRGTWVFNRiYDY----GQPIDIAMNRKCI 242
Cdd:COG2072 152 DFAGEQLHSADWRNPVDLAGKRVLVVGTGASAVQIAPELARVAAHVTVFQRTPPWVLPR-PNYdperGRPANYLGLEAPP 230

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462 243 SDLRSFVPAWLtntvvEAKLNQRFDHQAYG-LKPSHRVFGAHPTVNDELPNRIACGTVRIK-PNISKFTETGVLFEDGSL 320
Cdd:COG2072 231 ALNRRDARAWL-----RRLLRAQVKDPELGlLTPDYPPGCKRPLLSTDYYEALRRGNVELVtGGIERITEDGVVFADGTE 305

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 25150462 321 IEqVDEIVMSTGFSFEFNLVENGQLI-RTHDNQVSLYQYMFPieLGDHNsLAVIGLVQPFG--SIMPLSEMQAR 391
Cdd:COG2072 306 HE-VDVIVWATGFRADLPWLAPLDVRgRDGRSGPRAYLGVVV--PGFPN-LFFLGPNSPSGhsSLTLGAERQAR 375
PLN02172 PLN02172
flavin-containing monooxygenase FMO GS-OX
 1-443 2.68e-39

flavin-containing monooxygenase FMO GS-OX


Pssm-ID: 215116 [Multi-domain]  Cd Length: 461  Bit Score: 148.86  E-value: 2.68e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462    1 MAP-----NNKKLLIVGAGASGLPSLRHALLYGIDVTCFERTKDVGGLWHYKPQETE------------LSSVMKTTVIN 63
Cdd:PLN02172   1 MAPaqnpiNSQHVAVIGAGAAGLVAARELRREGHTVVVFEREKQVGGLWVYTPKSESdplsldptrsivHSSVYESLRTN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462   64 TSKEMTAYSDFP------PESRMAN-FMHNTEMYRYLLNYSKHYELEKHIKFNHKVNSIDrnedyEKTGKWKVNYTDDKG 136
Cdd:PLN02172  81 LPRECMGYRDFPfvprfdDESRDSRrYPSHREVLAYLQDFAREFKIEEMVRFETEVVRVE-----PVDGKWRVQSKNSGG 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462  137 ATHDAVFDGVMLCSGHHTTPNWPQkFRGQDDFKGRIIHSHSYKDHRGYEDKVVVVVGIGNSGGDVAVELSRIAKQVYLVT 216
Cdd:PLN02172 156 FSKDEIFDAVVVCNGHYTEPNVAH-IPGIKSWPGKQIHSHNYRVPDPFKNEVVVVIGNFASGADISRDIAKVAKEVHIAS 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462  217 RRgtwvfnriydygqpidiamnrkcisdlrsfvpawltntvveaklnqrfdhqayglKPSHrVFGAHPTVNDELpnriac 296
Cdd:PLN02172 235 RA-------------------------------------------------------SESD-TYEKLPVPQNNL------ 252

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462  297 gtvRIKPNISKFTETG-VLFEDGSLIeQVDEIVMSTGFSFEFNLVENGQLIRTHDNQVS-LYQYMFPIELGDhnSLAVIG 374
Cdd:PLN02172 253 ---WMHSEIDTAHEDGsIVFKNGKVV-YADTIVHCTGYKYHFPFLETNGYMRIDENRVEpLYKHVFPPALAP--GLSFIG 326

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 25150462  375 LvQPFGSIMPLSEMQARVYLEEFTGNHVLPKKNEMTQNV---HDKLETMA--RRYvTSRRHTIQVDYVDYIEEL 443
Cdd:PLN02172 327 L-PAMGIQFVMFEIQSKWVAAVLSGRVTLPSEDKMMEDInawYASLEALGipKRY-THKLGKIQSEYLNWIAEE 398
Pyr_redox_3 pfam13738
Pyridine nucleotide-disulphide oxidoreductase;
88-355 1.07e-14

Pyridine nucleotide-disulphide oxidoreductase;


Pssm-ID: 404603 [Multi-domain]  Cd Length: 296  Bit Score: 74.57  E-value: 1.07e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462    88 EMYRYLLNYSKHYELekHIKFNHKVNSIDRNEDYEKTgkwkvnyTDDKG---ATHdavfdgVMLCSGHHTTPNWPqkfrg 164
Cdd:pfam13738  76 EYAEYLRRVADHFEL--PINLFEEVTSVKKEDDGFVV-------TTSKGtyqARY------VIIATGEFDFPNKL----- 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462   165 qdDFKGRIIHSHSYKDHRGYEDKVVVVVGIGNSGGDVAVELSRIAKQVYLVTRRGTWvFNRIYDYGQpidiamnrkcisd 244
Cdd:pfam13738 136 --GVPELPKHYSYVKDFHPYAGQKVVVIGGYNSAVDAALELVRKGARVTVLYRGSEW-EDRDSDPSY------------- 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462   245 lrsfvpaWLtNTVVEAKLNQRFDHQAYGLkpshrVFGAHptvndelpnriacgTVRIKPNISKFTetgVLFEDGSLIEQV 324
Cdd:pfam13738 200 -------SL-SPDTLNRLEELVKNGKIKA-----HFNAE--------------VKEITEVDVSYK---VHTEDGRKVTSN 249

                         250       260       270
                  ....*....|....*....|....*....|.
gi 25150462   325 DEIVMSTGFSFEFNLVENGQLIRTHDNQVSL 355
Cdd:pfam13738 250 DDPILATGYHPDLSFLKKGLFELDEDGRPVL 280
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
7-218 5.43e-13

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 69.76  E-value: 5.43e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462   7 KLLIVGAGASGLPSLRHALLYGIDVTCFERtKDVGGlwhykpqetelsSVMKTTVINtskemtaysDFP--PESRMANfm 84
Cdd:COG0492   2 DVVIIGAGPAGLTAAIYAARAGLKTLVIEG-GEPGG------------QLATTKEIE---------NYPgfPEGISGP-- 57

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462  85 hntEMYRYLLNYSKHYELEKHikfNHKVNSIDRNEDYektgkWKVnyTDDKGATHDAvfDGVMLCSGhhTTPNWPQkFRG 164
Cdd:COG0492  58 ---ELAERLREQAERFGAEIL---LEEVTSVDKDDGP-----FRV--TTDDGTEYEA--KAVIIATG--AGPRKLG-LPG 119

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 25150462 165 QDDFKGRIIHSHSYKDHRGYEDKVVVVVGIGNSGGDVAVELSRIAKQVYLVTRR 218
Cdd:COG0492 120 EEEFEGRGVSYCATCDGFFFRGKDVVVVGGGDSALEEALYLTKFASKVTLIHRR 173
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 6-326 8.69e-08

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 53.86  E-value: 8.69e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462     6 KKLLIVGAGASGLPSLRHALLYGIDVTCFErtkdVGGLWHY-KPQEtelssvmkttvintSKEMTAYSDFPPESRmanfm 84
Cdd:pfam07992   1 YDVVVIGGGPAGLAAALTLAQLGGKVTLIE----DEGTCPYgGCVL--------------SKALLGAAEAPEIAS----- 57

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462    85 HNTEMYRYLLNYSKhyELEKHIKFNHKVN--SIDRnedyeKTGKWKVNYTDDKGATHDAvFDGVMLCSGHHT-TPNWPQK 161
Cdd:pfam07992  58 LWADLYKRKEEVVK--KLNNGIEVLLGTEvvSIDP-----GAKKVVLEELVDGDGETIT-YDRLVIATGARPrLPPIPGV 129

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462   162 frGQDDFKGRIIHSHSYKDHRGYEDKVVVVVGIGNSGGDVAVELSRIAKQVYLVTRRGTwvFNRIYDY--GQPIDIAMNR 239
Cdd:pfam07992 130 --ELNVGFLVRTLDSAEALRLKLLPKRVVVVGGGYIGVELAAALAKLGKEVTLIEALDR--LLRAFDEeiSAALEKALEK 205

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462   240 KCIsdlrsfvpAWLTNTVVEaklnqRFDHQAYGLKpshrvfgahptVNDELPNRIACGTVRI----KPNISKFTETGV-L 314
Cdd:pfam07992 206 NGV--------EVRLGTSVK-----EIIGDGDGVE-----------VILKDGTEIDADLVVVaigrRPNTELLEAAGLeL 261

                         330
                  ....*....|..
gi 25150462   315 FEDGSLieQVDE 326
Cdd:pfam07992 262 DERGGI--VVDE 271
Lys_Orn_oxgnase pfam13434
L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase; This is a family of Rossmann fold ...
 102-335 9.81e-05

L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase; This is a family of Rossmann fold oxidoreductases that catalyze NADPH-dependent hydroxylation and are involved in siderophore biosynthesis. This family includes L-ornithine 5-monooxygenase, which catalyzes the hydroxylation of L-ornithine at the N5 position, and L-lysine 6-monooxygenase, which catalyzes the hydroxylation of lysine at the N6 position (EC:1.14.13.59).


Pssm-ID: 433204 [Multi-domain]  Cd Length: 338  Bit Score: 44.50  E-value: 9.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462   102 LEKHIKFNHKVNSIDRNEDYEKTGkWKVNYTDDKGATHdaVFDGVMLCSGHHTTPNWPQKFRGqddfKGRIIHSHSYKDH 181
Cdd:pfam13434 108 LPNRLRFGQEVESVEPDAERGEPL-LRVRVRDADGEET--TFLARNLVLGTGGEPYIPECARG----GERVFHSSEYLER 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462   182 --RGYEDKVVVVVGIGNSGGDVAVELSR--IAKQVYLVTRRG-------TWVFNRIYD-------YGQPID--IAMNRKC 241
Cdd:pfam13434 181 idRLAAKKRIAVVGSGQSAAEIFRDLLRrgPAYELTWVTRSPnffplddSPFVNEIFSpeyvdyfYSLPEDtrRALLREQ 260

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462   242 ISDLRSFVPAWLTNTVVEAKLNQRFDHQA-YGLKPSHRVFGAHPTvndelpnriACGTVRIkpnISKFTETGVLFEdgsl 320
Cdd:pfam13434 261 KGTNYDGIDPSLIEEIYRLLYEQRVDGDPrHRLLPNREVQSAERV---------GDGGVEL---TLRDGEQGREET---- 324

                         250
                  ....*....|....*
gi 25150462   321 iEQVDEIVMSTGFSF 335
Cdd:pfam13434 325 -LETDVVVLATGYRR 338
PRK10262 PRK10262
thioredoxin reductase; Provisional
 101-226 1.50e-03

thioredoxin reductase; Provisional


Pssm-ID: 182343 [Multi-domain]  Cd Length: 321  Bit Score: 40.82  E-value: 1.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150462  101 ELEKHIKFNHkVNSID-RNEDYEKTGkwkvnytDDKGATHDAVFDGVMLCSGHHTTPNwpqkfrgQDDFKGRIIHSHSYK 179
Cdd:PRK10262  75 KFETEIIFDH-INKVDlQNRPFRLTG-------DSGEYTCDALIIATGASARYLGLPS-------EEAFKGRGVSACATC 139

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 25150462  180 DHRGYEDKVVVVVGIGNSGGDVAVELSRIAKQVYLVTRRGTWVFNRI 226
Cdd:PRK10262 140 DGFFYRNQKVAVIGGGNTAVEEALYLSNIASEVHLIHRRDGFRAEKI 186
PRK07233 PRK07233
hypothetical protein; Provisional
 7-43 2.44e-03

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 40.26  E-value: 2.44e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 25150462    7 KLLIVGAGASGLPSLRHALLYGIDVTCFERTKDVGGL 43
Cdd:PRK07233   1 KIAIVGGGIAGLAAAYRLAKRGHEVTVFEADDQLGGL 37
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
10-45 6.42e-03

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 35.20  E-value: 6.42e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 25150462    10 IVGAGASGLPSLRHALLYGIDVTCFERTKDVGGLWH 45
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRGFRVLVLEKRDRLGGNAY 36
NAD_binding_9 pfam13454
FAD-NAD(P)-binding;
10-76 7.53e-03

FAD-NAD(P)-binding;


Pssm-ID: 433222 [Multi-domain]  Cd Length: 155  Bit Score: 37.26  E-value: 7.53e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 25150462    10 IVGAGASGLPSLRH----ALLYGIDVTCFERTKD-VGGLWHYKPQETELssvmkttvINT-SKEMTAYSDFPP 76
Cdd:pfam13454   2 IVGGGPSGLALLERllarAPKRPLEITLFDPSPPgAGGVYRTDQSPEHL--------LNVpASRMSLFPDDPP 66
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 6-43 8.48e-03

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 38.66  E-value: 8.48e-03
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 25150462   6 KKLLIVGAGASGLPSLRHALLYGIDVTCFERTKDVGGL 43
Cdd:COG1232   2 KRVAVIGGGIAGLTAAYRLAKAGHEVTVLEASDRVGGL 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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