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Conserved domains on  [gi|392899715|ref|NP_501467|]
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Amino acid transporter transmembrane domain-containing protein [Caenorhabditis elegans]

Protein Classification

SLC5/6 family protein( domain architecture ID 124)

SLC5/6 (solute carrier 5/6) family protein may function as a transporter

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
SLC5-6-like_sbd super family cl00456
Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the ...
6-410 3.39e-46

Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporters or solute sodium symporters), SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporters or Na+/Cl--dependent transporters), and nucleobase-cation-symport-1 (NCS1) transporters. SLC5s co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. SLC6s include Na+/Cl--dependent plasma membrane transporters for the monoamine neurotransmitters serotonin, dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. Members of this superfamily are important in human physiology and disease. They contain a functional core of 10 transmembrane helices (TMs): an inverted structural repeat, TMs1-5 and TMs6-10; TMs numbered to conform to the SLC6 Aquifex aeolicus LeuT.


The actual alignment was detected with superfamily member pfam01490:

Pssm-ID: 444915  Cd Length: 410  Bit Score: 165.17  E-value: 3.39e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899715    6 SWYIAVIFTFGETAGSGLVALPSAMQSLGFMGGTITLIVMCLITYYTATLLGNNWIIMktrwsEYSEHCRNPYPEMAHKA 85
Cdd:pfam01490   4 SAWQAVFNLINAIIGAGVLSLPYAFKQLGWIPGLILLLIVGLISLYTAHLLVRCSKEV-----PVTGKRNKSYGDLGYRL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899715   86 LGTWMGMTTNFCTYFTVFGGTAVFSLLAAKTLAEVLNGFGIGATM--CTTLITVGLILWPFVMLKSPAHFWQVSIVATIS 163
Cdd:pfam01490  79 LGPKGRLLILFAILLNLFGVCISYLIFAGDNLPAIFDSFFDTCPIslVYFIIIFGLIFIPLSFIPNLSALSILSLLAAVS 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899715  164 TVTAVALILFGYFLDAKGC---YPHS-SYPDFTPTAASNSLATIIFAYGGHPCIPTIVHDMKTPQHY---FRCFLLSYIA 236
Cdd:pfam01490 159 SLYYIVILVLSVAEGIVLTaqgVGHLgSKTNIKLAGTFLAIGIIVFAFEGHAVLLPIQNEMKNPSKFkamTKILLTAIII 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899715  237 LFLLYTPVSLFGFWIYG-DSVSDSIISSIQNDSLRRGISILIAVHVFFSVLIIVNPLLQASEHLFRVKHEFGIG------ 309
Cdd:pfam01490 239 ATVLYILIGLVGYLAFGdNVKGNILLNLPKSAWLIDIANLLLVLHVILSFPLQLFPIRQIVENLLFRKEAPFGAsgknnp 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899715  310 -----RFIIRSIVFWIIIFSAASVPNFGVVVNLVGGSTLPLLVLIFPPLFAMCLevrqkleddgakeeFSLKSIWKYHPK 384
Cdd:pfam01490 319 kskllRVVIRSGLVVITYLIAISVPFFGDLLSLVGATSCAPLSFILPPLFHLKL--------------KKTKKKSQEKLW 384
                         410       420
                  ....*....|....*....|....*.
gi 392899715  385 PRLLLDIFIYVLGTYVMVHSTYHSLS 410
Cdd:pfam01490 385 KPDILDVICIVIGLLLMAYGVAGLIL 410
 
Name Accession Description Interval E-value
Aa_trans pfam01490
Transmembrane amino acid transporter protein; This transmembrane region is found in many amino ...
6-410 3.39e-46

Transmembrane amino acid transporter protein; This transmembrane region is found in many amino acid transporters including UNC-47 and MTR. UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT). UNC-47 is predicted to have 10 transmembrane domains. MTR is a N system amino acid transporter system protein involved in methyltryptophan resistance. Other members of this family include proline transporters and amino acid permeases.


Pssm-ID: 279788  Cd Length: 410  Bit Score: 165.17  E-value: 3.39e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899715    6 SWYIAVIFTFGETAGSGLVALPSAMQSLGFMGGTITLIVMCLITYYTATLLGNNWIIMktrwsEYSEHCRNPYPEMAHKA 85
Cdd:pfam01490   4 SAWQAVFNLINAIIGAGVLSLPYAFKQLGWIPGLILLLIVGLISLYTAHLLVRCSKEV-----PVTGKRNKSYGDLGYRL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899715   86 LGTWMGMTTNFCTYFTVFGGTAVFSLLAAKTLAEVLNGFGIGATM--CTTLITVGLILWPFVMLKSPAHFWQVSIVATIS 163
Cdd:pfam01490  79 LGPKGRLLILFAILLNLFGVCISYLIFAGDNLPAIFDSFFDTCPIslVYFIIIFGLIFIPLSFIPNLSALSILSLLAAVS 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899715  164 TVTAVALILFGYFLDAKGC---YPHS-SYPDFTPTAASNSLATIIFAYGGHPCIPTIVHDMKTPQHY---FRCFLLSYIA 236
Cdd:pfam01490 159 SLYYIVILVLSVAEGIVLTaqgVGHLgSKTNIKLAGTFLAIGIIVFAFEGHAVLLPIQNEMKNPSKFkamTKILLTAIII 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899715  237 LFLLYTPVSLFGFWIYG-DSVSDSIISSIQNDSLRRGISILIAVHVFFSVLIIVNPLLQASEHLFRVKHEFGIG------ 309
Cdd:pfam01490 239 ATVLYILIGLVGYLAFGdNVKGNILLNLPKSAWLIDIANLLLVLHVILSFPLQLFPIRQIVENLLFRKEAPFGAsgknnp 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899715  310 -----RFIIRSIVFWIIIFSAASVPNFGVVVNLVGGSTLPLLVLIFPPLFAMCLevrqkleddgakeeFSLKSIWKYHPK 384
Cdd:pfam01490 319 kskllRVVIRSGLVVITYLIAISVPFFGDLLSLVGATSCAPLSFILPPLFHLKL--------------KKTKKKSQEKLW 384
                         410       420
                  ....*....|....*....|....*.
gi 392899715  385 PRLLLDIFIYVLGTYVMVHSTYHSLS 410
Cdd:pfam01490 385 KPDILDVICIVIGLLLMAYGVAGLIL 410
SdaC COG0814
Amino acid permease [Amino acid transport and metabolism];
15-241 1.05e-04

Amino acid permease [Amino acid transport and metabolism];


Pssm-ID: 440576  Cd Length: 401  Bit Score: 44.36  E-value: 1.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899715  15 FGETAGSGLVALPSAMQSLGFMGGTITLIVMCLITYYTATLLgnnwiimkTRWSEYSEHCRNpYPEMAHKALGTWMGMTT 94
Cdd:COG0814   20 AGTAIGAGMLALPIAAGGGGFWPSLLLLLLAWPLMYLSHLLL--------LEVNLSSPPGAD-ITTVVEEYLGKGGGILI 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899715  95 NFCTYFTVFGGTAVFSLLAAKTLAEVLN---GFGIGATMCTTLITVGLIlwpFVMLKSpahfwqVSIVATISTVTAVALI 171
Cdd:COG0814   91 GLLYFFLLYPLLLAYISGGGNILASFLVnqlGLTIPRWLLSLIFILVLG---AIVWLG------TRLVDRVNRILVFPKI 161
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 392899715 172 LFgYFLDAKGCYPHSSYPDFTPTAASNSLATI-------IFAYGGHPCIPTIVHDM-KTPQHYFRCFLLSYIALFLLY 241
Cdd:COG0814  162 IA-FLLLSLYLIPHWNLANLLNSALPSYLKYLwlalpvlLTSFGFHPIIPSLVKYYrKDAKKLRRAILIGSLIPLVIY 238
PLN03074 PLN03074
auxin influx permease; Provisional
23-356 4.59e-03

auxin influx permease; Provisional


Pssm-ID: 215559  Cd Length: 473  Bit Score: 39.32  E-value: 4.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899715  23 LVALPSAMQSLGFMGGTITLIVMCLITYYTATLLGNNWIIMKTRWSEYSEHCRN---PYPEMAHKALG-TWMGMTTNFCT 98
Cdd:PLN03074  64 LLTLPYSFSQLGMLSGILFQIFYGLLGSWTAYLISVLYVEYRARKEREKVDFKNhviQWFEVLDGLLGpYWKNVGLAFNC 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899715  99 YFTVFGgtAVFSLLAAKTLAEVLNG--------FGIGATMCTTlitvglilwpfVMLKSPAHFWQVSIVATI-STVTA-- 167
Cdd:PLN03074 144 TFLLFG--SVIQLIACASNIYYINDnldkrtwtYIFGACCATT-----------VFIPSFHNYRIWSFLGLLmTTYTAwy 210
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899715 168 --VALILFGYFLDAKGCYPHSSYPDFtpTAASNslatIIFAYGGHPCIPTIVHDMKTPQHYFRCFLLSYIALFLLYTPVS 245
Cdd:PLN03074 211 mtIAALSHGQVEGVKHSGPTKLVLYF--TGATN----ILYTFGGHAVTVEIMHAMWKPQKFKYIYLAATLYVLTLTLPSA 284
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899715 246 LFGFWIYGDSVSDSI--ISSIQNDSLRRGISILIAVHVFFSVLIIVNPLLQASEHLFRVKHEFGI-GRFIIRSIVFWIII 322
Cdd:PLN03074 285 AAVYWAFGDELLTHSnaFSLLPRSGWRDAAVILMLIHQFITFGFACTPLYFVWEKAIGVHDTKSIcLRALARLPVVVPIW 364
                        330       340       350
                 ....*....|....*....|....*....|....
gi 392899715 323 FSAASVPNFGVVVNLVGGSTLPLLVLIFPPLFAM 356
Cdd:PLN03074 365 FLAIIFPFFGPINSAVGALLVSFTVYIIPSLAHM 398
 
Name Accession Description Interval E-value
Aa_trans pfam01490
Transmembrane amino acid transporter protein; This transmembrane region is found in many amino ...
6-410 3.39e-46

Transmembrane amino acid transporter protein; This transmembrane region is found in many amino acid transporters including UNC-47 and MTR. UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT). UNC-47 is predicted to have 10 transmembrane domains. MTR is a N system amino acid transporter system protein involved in methyltryptophan resistance. Other members of this family include proline transporters and amino acid permeases.


Pssm-ID: 279788  Cd Length: 410  Bit Score: 165.17  E-value: 3.39e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899715    6 SWYIAVIFTFGETAGSGLVALPSAMQSLGFMGGTITLIVMCLITYYTATLLGNNWIIMktrwsEYSEHCRNPYPEMAHKA 85
Cdd:pfam01490   4 SAWQAVFNLINAIIGAGVLSLPYAFKQLGWIPGLILLLIVGLISLYTAHLLVRCSKEV-----PVTGKRNKSYGDLGYRL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899715   86 LGTWMGMTTNFCTYFTVFGGTAVFSLLAAKTLAEVLNGFGIGATM--CTTLITVGLILWPFVMLKSPAHFWQVSIVATIS 163
Cdd:pfam01490  79 LGPKGRLLILFAILLNLFGVCISYLIFAGDNLPAIFDSFFDTCPIslVYFIIIFGLIFIPLSFIPNLSALSILSLLAAVS 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899715  164 TVTAVALILFGYFLDAKGC---YPHS-SYPDFTPTAASNSLATIIFAYGGHPCIPTIVHDMKTPQHY---FRCFLLSYIA 236
Cdd:pfam01490 159 SLYYIVILVLSVAEGIVLTaqgVGHLgSKTNIKLAGTFLAIGIIVFAFEGHAVLLPIQNEMKNPSKFkamTKILLTAIII 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899715  237 LFLLYTPVSLFGFWIYG-DSVSDSIISSIQNDSLRRGISILIAVHVFFSVLIIVNPLLQASEHLFRVKHEFGIG------ 309
Cdd:pfam01490 239 ATVLYILIGLVGYLAFGdNVKGNILLNLPKSAWLIDIANLLLVLHVILSFPLQLFPIRQIVENLLFRKEAPFGAsgknnp 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899715  310 -----RFIIRSIVFWIIIFSAASVPNFGVVVNLVGGSTLPLLVLIFPPLFAMCLevrqkleddgakeeFSLKSIWKYHPK 384
Cdd:pfam01490 319 kskllRVVIRSGLVVITYLIAISVPFFGDLLSLVGATSCAPLSFILPPLFHLKL--------------KKTKKKSQEKLW 384
                         410       420
                  ....*....|....*....|....*.
gi 392899715  385 PRLLLDIFIYVLGTYVMVHSTYHSLS 410
Cdd:pfam01490 385 KPDILDVICIVIGLLLMAYGVAGLIL 410
SdaC COG0814
Amino acid permease [Amino acid transport and metabolism];
15-241 1.05e-04

Amino acid permease [Amino acid transport and metabolism];


Pssm-ID: 440576  Cd Length: 401  Bit Score: 44.36  E-value: 1.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899715  15 FGETAGSGLVALPSAMQSLGFMGGTITLIVMCLITYYTATLLgnnwiimkTRWSEYSEHCRNpYPEMAHKALGTWMGMTT 94
Cdd:COG0814   20 AGTAIGAGMLALPIAAGGGGFWPSLLLLLLAWPLMYLSHLLL--------LEVNLSSPPGAD-ITTVVEEYLGKGGGILI 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899715  95 NFCTYFTVFGGTAVFSLLAAKTLAEVLN---GFGIGATMCTTLITVGLIlwpFVMLKSpahfwqVSIVATISTVTAVALI 171
Cdd:COG0814   91 GLLYFFLLYPLLLAYISGGGNILASFLVnqlGLTIPRWLLSLIFILVLG---AIVWLG------TRLVDRVNRILVFPKI 161
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 392899715 172 LFgYFLDAKGCYPHSSYPDFTPTAASNSLATI-------IFAYGGHPCIPTIVHDM-KTPQHYFRCFLLSYIALFLLY 241
Cdd:COG0814  162 IA-FLLLSLYLIPHWNLANLLNSALPSYLKYLwlalpvlLTSFGFHPIIPSLVKYYrKDAKKLRRAILIGSLIPLVIY 238
PLN03074 PLN03074
auxin influx permease; Provisional
23-356 4.59e-03

auxin influx permease; Provisional


Pssm-ID: 215559  Cd Length: 473  Bit Score: 39.32  E-value: 4.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899715  23 LVALPSAMQSLGFMGGTITLIVMCLITYYTATLLGNNWIIMKTRWSEYSEHCRN---PYPEMAHKALG-TWMGMTTNFCT 98
Cdd:PLN03074  64 LLTLPYSFSQLGMLSGILFQIFYGLLGSWTAYLISVLYVEYRARKEREKVDFKNhviQWFEVLDGLLGpYWKNVGLAFNC 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899715  99 YFTVFGgtAVFSLLAAKTLAEVLNG--------FGIGATMCTTlitvglilwpfVMLKSPAHFWQVSIVATI-STVTA-- 167
Cdd:PLN03074 144 TFLLFG--SVIQLIACASNIYYINDnldkrtwtYIFGACCATT-----------VFIPSFHNYRIWSFLGLLmTTYTAwy 210
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899715 168 --VALILFGYFLDAKGCYPHSSYPDFtpTAASNslatIIFAYGGHPCIPTIVHDMKTPQHYFRCFLLSYIALFLLYTPVS 245
Cdd:PLN03074 211 mtIAALSHGQVEGVKHSGPTKLVLYF--TGATN----ILYTFGGHAVTVEIMHAMWKPQKFKYIYLAATLYVLTLTLPSA 284
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899715 246 LFGFWIYGDSVSDSI--ISSIQNDSLRRGISILIAVHVFFSVLIIVNPLLQASEHLFRVKHEFGI-GRFIIRSIVFWIII 322
Cdd:PLN03074 285 AAVYWAFGDELLTHSnaFSLLPRSGWRDAAVILMLIHQFITFGFACTPLYFVWEKAIGVHDTKSIcLRALARLPVVVPIW 364
                        330       340       350
                 ....*....|....*....|....*....|....
gi 392899715 323 FSAASVPNFGVVVNLVGGSTLPLLVLIFPPLFAM 356
Cdd:PLN03074 365 FLAIIFPFFGPINSAVGALLVSFTVYIIPSLAHM 398
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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