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Conserved domains on  [gi|17541936|ref|NP_501142|]
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Globin domain-containing protein [Caenorhabditis elegans]

Protein Classification

globin( domain architecture ID 10099307)

M-family globin similar to a variety of single-domain globins such as myoglobin and hemoglobin

CATH:  1.10.490.10
Gene Ontology:  GO:0019825|GO:0020037|GO:0005344|GO:0005506|GO:0015671
PubMed:  32863222|16061809|19281958|23209182
SCOP:  4000551

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Mb-like cd01040
myoglobin-like; M family globin domain; This family includes chimeric (FHbs/flavohemoglobins) ...
 169-310 1.38e-13

myoglobin-like; M family globin domain; This family includes chimeric (FHbs/flavohemoglobins) and single-domain globins: FHbs, Ngbs/neuroglobins, Cygb/cytoglobins, GbE/avian eye specific globin E, GbX/globin X, amphibian GbY/globin Y, Mb/myoglobin, HbA/hemoglobin-alpha, HbB/hemoglobin-beta, SDgbs/single-domain globins related to FHbs, and Adgb/androglobin. The M family exhibits the canonical secondary structure of hemoglobins, a 3-over-3 alpha-helical sandwich structure (3/3 Mb-fold), built by eight alpha-helical segments (named A through H). In Adgbs, the globin domain is split into two: helices C-H are followed by helices A-B and the two parts are separated by the IQ motif. Although rearranged, the globin domain of most Adgbs contains a number of conserved residues which play critical roles in heme-coordination and gas ligand binding. Adgbs have been omitted from this A-H helix cd.


:

Pssm-ID: 381254  Cd Length: 133  Bit Score: 66.71  E-value: 1.38e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17541936 169 VADSWRLVESRSSAaetsacFGLFVFQRVFSKIPMLRPLFGLSESDDVfDLPDNHPVRRHARLFTSILHISVKNVDELEA 248
Cdd:cd01040   1 VKSSWARVKKDKEE------FGVAIFLRLFEANPELKKLFPKFAGVDL-DLKGSPEFKAHAKRVVGALDSLIDNLDDPEA 73

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17541936 249 qVAPTVFKYGERHYRPDITPhmteENVRVFCAQIVCTVFDFLRDtEATPKCAESWIELMRYL 310
Cdd:cd01040  74 -LDALLRKLGKRHKRRGVTP----EHFEVFGEALLETLEEVLGE-AFTPEVEAAWRKLLDYI 129
 
Name Accession Description Interval E-value
Mb-like cd01040
myoglobin-like; M family globin domain; This family includes chimeric (FHbs/flavohemoglobins) ...
 169-310 1.38e-13

myoglobin-like; M family globin domain; This family includes chimeric (FHbs/flavohemoglobins) and single-domain globins: FHbs, Ngbs/neuroglobins, Cygb/cytoglobins, GbE/avian eye specific globin E, GbX/globin X, amphibian GbY/globin Y, Mb/myoglobin, HbA/hemoglobin-alpha, HbB/hemoglobin-beta, SDgbs/single-domain globins related to FHbs, and Adgb/androglobin. The M family exhibits the canonical secondary structure of hemoglobins, a 3-over-3 alpha-helical sandwich structure (3/3 Mb-fold), built by eight alpha-helical segments (named A through H). In Adgbs, the globin domain is split into two: helices C-H are followed by helices A-B and the two parts are separated by the IQ motif. Although rearranged, the globin domain of most Adgbs contains a number of conserved residues which play critical roles in heme-coordination and gas ligand binding. Adgbs have been omitted from this A-H helix cd.


Pssm-ID: 381254  Cd Length: 133  Bit Score: 66.71  E-value: 1.38e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17541936 169 VADSWRLVESRSSAaetsacFGLFVFQRVFSKIPMLRPLFGLSESDDVfDLPDNHPVRRHARLFTSILHISVKNVDELEA 248
Cdd:cd01040   1 VKSSWARVKKDKEE------FGVAIFLRLFEANPELKKLFPKFAGVDL-DLKGSPEFKAHAKRVVGALDSLIDNLDDPEA 73

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17541936 249 qVAPTVFKYGERHYRPDITPhmteENVRVFCAQIVCTVFDFLRDtEATPKCAESWIELMRYL 310
Cdd:cd01040  74 -LDALLRKLGKRHKRRGVTP----EHFEVFGEALLETLEEVLGE-AFTPEVEAAWRKLLDYI 129
Globin pfam00042
Globin;
191-310 7.83e-13

Globin;


Pssm-ID: 459646 [Multi-domain]  Cd Length: 117  Bit Score: 64.23  E-value: 7.83e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17541936   191 LFVFQRVFSKIPMLRPLFGLSEsDDVFDLPDNHPVRRHARLFTSILHISVKNVDELEAQVApTVFKYGERHYRpdiTPHM 270
Cdd:pfam00042   1 AEILARLFTAYPDTKAYFPRFE-KSADDLKGSPKFKAHGKKVLAALGEAVKHLDDLAALNA-ALKKLGARHKE---KRGV 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 17541936   271 TEENVRVFcAQIVCTVFDFLRdTEATPKCAESWIELMRYL 310
Cdd:pfam00042  76 DPANFKLF-GEALLVVLAEHL-GEFTPETKAAWDKALDVI 113
 
Name Accession Description Interval E-value
Mb-like cd01040
myoglobin-like; M family globin domain; This family includes chimeric (FHbs/flavohemoglobins) ...
 169-310 1.38e-13

myoglobin-like; M family globin domain; This family includes chimeric (FHbs/flavohemoglobins) and single-domain globins: FHbs, Ngbs/neuroglobins, Cygb/cytoglobins, GbE/avian eye specific globin E, GbX/globin X, amphibian GbY/globin Y, Mb/myoglobin, HbA/hemoglobin-alpha, HbB/hemoglobin-beta, SDgbs/single-domain globins related to FHbs, and Adgb/androglobin. The M family exhibits the canonical secondary structure of hemoglobins, a 3-over-3 alpha-helical sandwich structure (3/3 Mb-fold), built by eight alpha-helical segments (named A through H). In Adgbs, the globin domain is split into two: helices C-H are followed by helices A-B and the two parts are separated by the IQ motif. Although rearranged, the globin domain of most Adgbs contains a number of conserved residues which play critical roles in heme-coordination and gas ligand binding. Adgbs have been omitted from this A-H helix cd.


Pssm-ID: 381254  Cd Length: 133  Bit Score: 66.71  E-value: 1.38e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17541936 169 VADSWRLVESRSSAaetsacFGLFVFQRVFSKIPMLRPLFGLSESDDVfDLPDNHPVRRHARLFTSILHISVKNVDELEA 248
Cdd:cd01040   1 VKSSWARVKKDKEE------FGVAIFLRLFEANPELKKLFPKFAGVDL-DLKGSPEFKAHAKRVVGALDSLIDNLDDPEA 73

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17541936 249 qVAPTVFKYGERHYRPDITPhmteENVRVFCAQIVCTVFDFLRDtEATPKCAESWIELMRYL 310
Cdd:cd01040  74 -LDALLRKLGKRHKRRGVTP----EHFEVFGEALLETLEEVLGE-AFTPEVEAAWRKLLDYI 129
Globin pfam00042
Globin;
191-310 7.83e-13

Globin;


Pssm-ID: 459646 [Multi-domain]  Cd Length: 117  Bit Score: 64.23  E-value: 7.83e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17541936   191 LFVFQRVFSKIPMLRPLFGLSEsDDVFDLPDNHPVRRHARLFTSILHISVKNVDELEAQVApTVFKYGERHYRpdiTPHM 270
Cdd:pfam00042   1 AEILARLFTAYPDTKAYFPRFE-KSADDLKGSPKFKAHGKKVLAALGEAVKHLDDLAALNA-ALKKLGARHKE---KRGV 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 17541936   271 TEENVRVFcAQIVCTVFDFLRdTEATPKCAESWIELMRYL 310
Cdd:pfam00042  76 DPANFKLF-GEALLVVLAEHL-GEFTPETKAAWDKALDVI 113
GbX cd12137
Globin_X (GbX); Zebrafish globin X (GbX) is expressed at low levels in neurons of the central ...
 164-310 4.60e-04

Globin_X (GbX); Zebrafish globin X (GbX) is expressed at low levels in neurons of the central nervous system, and appears to be associated with the sensory system. GbX is likely to be attached to the cell membrane via S-palmitoylation and N-myristoylation. It's unlikely to have a true respiratory function as it is membrane-associated. It has been suggested that it may protect the lipids in the cell membrane from oxidation or act as a redox-sensing or signaling protein. Zebrafish GbX is hexacoordinate, and displays cooperative O2 binding.


Pssm-ID: 271287  Cd Length: 145  Bit Score: 39.97  E-value: 4.60e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17541936 164 ESCEVVADSWRLVEsrssaaETSACFGLFVFQRVFSKIPMLRPLFGLSESDDVFDLPDNHPVRRHARLFTSILHISVKNV 243
Cdd:cd12137   4 RQKQLIESSWSILQ------EDIAKVGVIMFVRLFETHPDCKDAFFPFRDVDLEDLRHSKELRAHGLRVLSFVEKSLARL 77

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17541936 244 DELEaQVAPTVFKYGERHYRPDITPhmteENVRVFCAQIVCTVFDFLRDtEATPKCAESWIELMRYL 310
Cdd:cd12137  78 HQPD-KLEELLHELGRKHYRYNAKV----KYVDLVGQQFIFAIEPVLKE-QWTPELEEAWKTLFRYL 138
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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