NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|17542112|ref|NP_500696|]
View 

Seven TM Receptor [Caenorhabditis elegans]

Protein Classification

class R serpentine receptor( domain architecture ID 10563422)

class R serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 9-312 1.18e-93

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402099  Cd Length: 307  Bit Score: 280.88  E-value: 1.18e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542112     9 VQNVAFSMAFITNCTLILLIFSRSPFKLGTYKYLMVYFASVSLFYSFLECLLNPLLLSYKDCFQVIVKLQFSN--PKVDR 86
Cdd:pfam10326   4 IQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGlsKSVGQ 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542112    87 YILYYGCGICGVLMPMFVVHFIFRYFAMQRKGNLKYFEGWYFLYWLSVPLISGFLWAQTLFAFLYEDTESSDYMREILLE 166
Cdd:pfam10326  84 ILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREELLE 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542112   167 NYGLNISDITYVGVLYYKKSISGSgTEPNFTGLQGVCVLGTIMTVCFCFIIYFGTLTYKRIMHLILEGrSEYTRRLQKQL 246
Cdd:pfam10326 164 NYNLDIDEVAYVGPVYYPTDENGS-KVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLG-SEKTRKLQKQL 241

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17542112   247 YQALVIQTIIPIFFLILPLTIYFYSPLFHFGNQTIGDWTALSTAIYPIIDPLPVIFVIDNYRLAVL 312
Cdd:pfam10326 242 FKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 9-312 1.18e-93

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 280.88  E-value: 1.18e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542112     9 VQNVAFSMAFITNCTLILLIFSRSPFKLGTYKYLMVYFASVSLFYSFLECLLNPLLLSYKDCFQVIVKLQFSN--PKVDR 86
Cdd:pfam10326   4 IQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGlsKSVGQ 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542112    87 YILYYGCGICGVLMPMFVVHFIFRYFAMQRKGNLKYFEGWYFLYWLSVPLISGFLWAQTLFAFLYEDTESSDYMREILLE 166
Cdd:pfam10326  84 ILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREELLE 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542112   167 NYGLNISDITYVGVLYYKKSISGSgTEPNFTGLQGVCVLGTIMTVCFCFIIYFGTLTYKRIMHLILEGrSEYTRRLQKQL 246
Cdd:pfam10326 164 NYNLDIDEVAYVGPVYYPTDENGS-KVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLG-SEKTRKLQKQL 241

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17542112   247 YQALVIQTIIPIFFLILPLTIYFYSPLFHFGNQTIGDWTALSTAIYPIIDPLPVIFVIDNYRLAVL 312
Cdd:pfam10326 242 FKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 9-312 1.18e-93

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 280.88  E-value: 1.18e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542112     9 VQNVAFSMAFITNCTLILLIFSRSPFKLGTYKYLMVYFASVSLFYSFLECLLNPLLLSYKDCFQVIVKLQFSN--PKVDR 86
Cdd:pfam10326   4 IQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGlsKSVGQ 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542112    87 YILYYGCGICGVLMPMFVVHFIFRYFAMQRKGNLKYFEGWYFLYWLSVPLISGFLWAQTLFAFLYEDTESSDYMREILLE 166
Cdd:pfam10326  84 ILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREELLE 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542112   167 NYGLNISDITYVGVLYYKKSISGSgTEPNFTGLQGVCVLGTIMTVCFCFIIYFGTLTYKRIMHLILEGrSEYTRRLQKQL 246
Cdd:pfam10326 164 NYNLDIDEVAYVGPVYYPTDENGS-KVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLG-SEKTRKLQKQL 241

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17542112   247 YQALVIQTIIPIFFLILPLTIYFYSPLFHFGNQTIGDWTALSTAIYPIIDPLPVIFVIDNYRLAVL 312
Cdd:pfam10326 242 FKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 12-308 8.19e-37

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 134.29  E-value: 8.19e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542112    12 VAFSMAFITNCTLILLIFSRSPFKLGTYKYLMVYFASVSLFYSFLECLLNPLLLSYKDCFQVIVK--LQFSNPKVDRYIL 89
Cdd:pfam10319  13 IFGVLSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFVSdgPFFEYSELGQHAL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542112    90 YYGCGICGVLMPMFVVHFIFRYFAMQRKGNL-KYFEGWYFLYWLSVPLISGFLWAQTLFAFLYEDTESSDYMREILLENY 168
Cdd:pfam10319  93 SARCSFISASYAVLLIHFIYRYLVLFNPQLTrHYFRPWGILISILFFLFHGSVWTAICYFLLRANDEIRDYIREDFRETY 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542112   169 GLNISDITYVGVLYYKKSisgsgTEPNFTGLQGVCVLGTIMTVCFCFIIYFGTLTYKRI--MHLILegrSEYTRRLQKQL 246
Cdd:pfam10319 173 GVDSMDINMLGALYWEAS-----DETVFRSWLGILLLTVISVYSIILYIVLGYKIMRKLnkMSVTM---SKKTKRLQKQL 244

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17542112   247 YQALVIQTIIPIFFLILPLTIYFYSPLFHF----GNQTIGDwTALSTaiYPIIDPLPVIFVIDNYR 308
Cdd:pfam10319 245 LKALIVQTIIPICISFSPCVLAWYSPIFGIdlgrWNNYLEV-IALSA--FPFIDPLAIILCLPVYR 307
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 86-317 4.40e-12

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 65.64  E-value: 4.40e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542112    86 RYILYYGCGICGVLMPMFVVHFIFRYFAMQRKGNLKYFEGWYFLYwlsvpLISGFLWAQTLFAFLYEDTESSDYMREILL 165
Cdd:pfam10318  86 PIQFYIGVTSLALVGVSIILLFENRYSILFTNKKRITWKKTRVLY-----LIFNYIIALLFLIPIYLNIPDQEAAKLKVL 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542112   166 ENYGLNISDITYVGVLYYKksisgsGTEPNFTGLqgvcVLGTIMTVCFCFIIYFGTLTYKRIMHLILEGRSEYTRRLQKQ 245
Cdd:pfam10318 161 KKLPCLPPEFFDNPPVFVL------AIDSTYFLI----CIVLLILILIIQILFFVFLTIYYLFKSVKSSLSKKTRKLQKK 230

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17542112   246 LYQALVIQTIIPIFFLILPLTIYFYSPLFHFGNQTIGDWTALSTAIYPIIDPLPVIFVIDNYRLAVLEFFGC 317
Cdd:pfam10318 231 FFIALIIQVSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 12-312 3.81e-10

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 59.87  E-value: 3.81e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542112    12 VAFSMAFITNCTLILLIFSRSPFKLGTYKYLMVYFASVSLFYSFLECLLNPLLLSYKDCFQVIVklqfsnPKVDRYILYY 91
Cdd:pfam10317   7 IFFILGLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQRIIPNGVSMALIS------YGPCKYFGPW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542112    92 GCGICGVLMPMFVVH--------FIFRYFAMqRKGNLKyFEGWYFLY-WLSVPLISGFLWAQTLFAflyeDTESSDYMRE 162
Cdd:pfam10317  81 FCYSGYSLLQHFLLHsgwsllltFYYRYYIL-KHVDPK-RKKLILLIiIHYIPSLSQLIVIFLSPT----DFLPVEALTK 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542112   163 ILLENYglNISDITYVGVLYYKKSisgsgtepnftglqgVCVLGTIMTVCFCFIIYFGTLTYKR-IMHLILEGR---SEY 238
Cdd:pfam10317 155 ELHPNY--NLTDYTVTGFSDLQSF---------------PALINTLIMTIPVFPIPIIILILRRkILKLLNSNSvnmSPT 217

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17542112   239 TRRLQKQLYQALVIQTIIPIFFLILPLTIYFYSPLFHFGNQTIGDWTALSTAIYPIIDPLPVIFVIDNYRLAVL 312
Cdd:pfam10317 218 TKAQHRQLIKGLTIQALLPLFSYIPGVTLYLLSQLTGTEFLILEYFIFVLPALPPLLDPLITIYFVTPYRRAIL 291
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH