NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|71999673|ref|NP_500675|]
View 

Seven TM Receptor [Caenorhabditis elegans]

Protein Classification

class R serpentine receptor( domain architecture ID 10563422)

class R serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 8-315 2.09e-90

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402099  Cd Length: 307  Bit Score: 272.79  E-value: 2.09e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999673     8 KSFIQSFAIFVLLITNILIIFLVKTKSPTKMGSYKHLLCYFSCLSMVYGVLEYFIEPYIFSDAVSGVLIMDLRGsaFELY 87
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKD--LGLS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999673    88 PKISLFLIVGGTSCFGVTIYAIAINFIYRYFAIQRQGRLRYFSGKRIIFWIFISLLGGII-SSSLFLTLGPNDEMTEHLR 166
Cdd:pfam10326  79 KSVGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIwGLLVYFFLGPDEETDEYLR 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999673   167 INLSKLYNLDVDRISYIGLLFWTTRS-GNLHLRLEDLLKYFALKGFMMIPFCIIIYCGVMSYLKIKNLNSQGeSEFSKRL 245
Cdd:pfam10326 159 EELLENYNLDIDEVAYVGPVYYPTDEnGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLG-SEKTRKL 237

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999673   246 QVQLYKALIAQFLIPMLFLFLPTSTFISCPLFKLDISWMNRIITILYSFYFALDPFPIIYLVDEYRKAVL 315
Cdd:pfam10326 238 QKQLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 8-315 2.09e-90

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 272.79  E-value: 2.09e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999673     8 KSFIQSFAIFVLLITNILIIFLVKTKSPTKMGSYKHLLCYFSCLSMVYGVLEYFIEPYIFSDAVSGVLIMDLRGsaFELY 87
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKD--LGLS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999673    88 PKISLFLIVGGTSCFGVTIYAIAINFIYRYFAIQRQGRLRYFSGKRIIFWIFISLLGGII-SSSLFLTLGPNDEMTEHLR 166
Cdd:pfam10326  79 KSVGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIwGLLVYFFLGPDEETDEYLR 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999673   167 INLSKLYNLDVDRISYIGLLFWTTRS-GNLHLRLEDLLKYFALKGFMMIPFCIIIYCGVMSYLKIKNLNSQGeSEFSKRL 245
Cdd:pfam10326 159 EELLENYNLDIDEVAYVGPVYYPTDEnGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLG-SEKTRKL 237

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999673   246 QVQLYKALIAQFLIPMLFLFLPTSTFISCPLFKLDISWMNRIITILYSFYFALDPFPIIYLVDEYRKAVL 315
Cdd:pfam10326 238 QKQLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 8-315 2.09e-90

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 272.79  E-value: 2.09e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999673     8 KSFIQSFAIFVLLITNILIIFLVKTKSPTKMGSYKHLLCYFSCLSMVYGVLEYFIEPYIFSDAVSGVLIMDLRGsaFELY 87
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKD--LGLS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999673    88 PKISLFLIVGGTSCFGVTIYAIAINFIYRYFAIQRQGRLRYFSGKRIIFWIFISLLGGII-SSSLFLTLGPNDEMTEHLR 166
Cdd:pfam10326  79 KSVGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIwGLLVYFFLGPDEETDEYLR 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999673   167 INLSKLYNLDVDRISYIGLLFWTTRS-GNLHLRLEDLLKYFALKGFMMIPFCIIIYCGVMSYLKIKNLNSQGeSEFSKRL 245
Cdd:pfam10326 159 EELLENYNLDIDEVAYVGPVYYPTDEnGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLG-SEKTRKL 237

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999673   246 QVQLYKALIAQFLIPMLFLFLPTSTFISCPLFKLDISWMNRIITILYSFYFALDPFPIIYLVDEYRKAVL 315
Cdd:pfam10326 238 QKQLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 21-314 1.12e-29

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 115.42  E-value: 1.12e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999673    21 ITNILIIFLVKTKSPTKMGSYKHLLCYFSCLSMVYGVLEYFIEPYIFSDAVSGVLImdLRGSAFELYPKISLFLIVGGTS 100
Cdd:pfam10319  20 IVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVF--VSDGPFFEYSELGQHALSARCS 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999673   101 CFGVTIYAIAINFIYRYFAIQRQGRL-RYFSGKRIIFWIFISLLGGII-SSSLFLTLGPNDEMTEHLRINLSKLYNLDVD 178
Cdd:pfam10319  98 FISASYAVLLIHFIYRYLVLFNPQLTrHYFRPWGILISILFFLFHGSVwTAICYFLLRANDEIRDYIREDFRETYGVDSM 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999673   179 RISYIGLLFW-----TTRSGNLHLRLEDLLKYFAlkgfmmIPFCIIIYCGVMSYLKIKNLNSqgeSEFSKRLQVQLYKAL 253
Cdd:pfam10319 178 DINMLGALYWeasdeTVFRSWLGILLLTVISVYS------IILYIVLGYKIMRKLNKMSVTM---SKKTKRLQKQLLKAL 248

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 71999673   254 IAQFLIPMLFLFLPTSTFISCPLFKLDISWMNRII-TILYSFYFALDPFPIIYLVDEYRKAV 314
Cdd:pfam10319 249 IVQTIIPICISFSPCVLAWYSPIFGIDLGRWNNYLeVIALSAFPFIDPLAIILCLPVYRNRI 310
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 7-315 2.60e-10

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 60.26  E-value: 2.60e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999673     7 LKSFIQSFAIFVLlITNILIIFLVKTKSPTKMGSYKHLLCYFSCLSMVYGVLEYFIEPYIFSDAVSGVLIMDlrGSAFEL 86
Cdd:pfam10317   1 FSIYYPIFFILGL-ILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQRIIPNGVSMALISY--GPCKYF 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999673    87 YPKISLFLIVGGTSCFGVTIYAIAINFIYRYFAIQRQGRLRYFSGKRIIFWIFISLLGGIIsssLFLTLGPNDEMTEHLR 166
Cdd:pfam10317  78 GPWFCYSGYSLLQHFLLHSGWSLLLTFYYRYYILKHVDPKRKKLILLIIIHYIPSLSQLIV---IFLSPTDFLPVEALTK 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999673   167 INLSklyNLDVDRISYIGLLfwttrsgnlhlrleDLLKYFALKGFMMIPFCIIIYCGVMSYLK---IKNLNSQGE--SEF 241
Cdd:pfam10317 155 ELHP---NYNLTDYTVTGFS--------------DLQSFPALINTLIMTIPVFPIPIIILILRrkiLKLLNSNSVnmSPT 217

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71999673   242 SKRLQVQLYKALIAQFLIPMLFLFLPTSTFISCPLFKLDISWMNRIITILYSFYFALDPFPIIYLVDEYRKAVL 315
Cdd:pfam10317 218 TKAQHRQLIKGLTIQALLPLFSYIPGVTLYLLSQLTGTEFLILEYFIFVLPALPPLLDPLITIYFVTPYRRAIL 291
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 10-320 6.63e-08

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 53.32  E-value: 6.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999673    10 FIQSFAIFVLLITNILIIFlvktKSPTKMGSYKHLLCYFSCLSMvygVLEYFI----EPYIFSDAVS----GVLimdlrg 81
Cdd:pfam10318  12 IITVISIPIHIFGFYCILF----KTPKKMKSVKWSLLNLHFWSA---LLDLSLsfltIPYIFLPALAgyplGLL------ 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999673    82 SAFELYPKISLFLIVGGTSCFGVTIYAIainFIYRYFAIQRQGRLRYFSGKRIIFWIFISLLGGIISSSLFLTLgPNDem 161
Cdd:pfam10318  79 SYLGVPTPIQFYIGVTSLALVGVSIILL---FENRYSILFTNKKRITWKKTRVLYLIFNYIIALLFLIPIYLNI-PDQ-- 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999673   162 tEHLRINLSKLYNLDVDRISYIGLLFWTTRSGNLHLrledllkyFALKGFMMIPFCIIIYCGVMSYLKIKNLNSQGESEF 241
Cdd:pfam10318 153 -EAAKLKVLKKLPCLPPEFFDNPPVFVLAIDSTYFL--------ICIVLLILILIIQILFFVFLTIYYLFKSVKSSLSKK 223

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 71999673   242 SKRLQVQLYKALIAQFLIPMLFLFLPTSTFISCPLFKLDISWMNRIITILYSFYFALDPFPIIYLVDEYRKAVLGFFRY 320
Cdd:pfam10318 224 TRKLQKKFFIALIIQVSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH