NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|17542116|ref|NP_500663|]
View 

Seven TM Receptor [Caenorhabditis elegans]

Protein Classification

class R serpentine receptor( domain architecture ID 10563422)

class R serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
10-316 1.26e-109

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402099  Cd Length: 307  Bit Score: 322.10  E-value: 1.26e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542116    10 KTLIQLISYCFALTSNTLLIFLIVTKSPKKMGTYRSLMCYFCIISLIFTTLDVIVKPNIYSRESAFFMMMDLRNRMLPRY 89
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542116    90 IEECLMSVLCGCCGMAIYGIAIHFVYRYFALERQGRLRFFKGAYQIFWFFIPIFGCLNWTFIAGYFFAMNPISTGYIAPM 169
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542116   170 IEEMYNISINDAAYSAAVFWPPNEQGVVEFHWRSGLGLINLVTSMSLSLSVVIYTGVKSLKKIKQLLGrLESKFSKNLQM 249
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKS-LGSEKTRKLQK 239
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17542116   250 QLYKALVAQTLIPVLFIFIPFGILFTCPLFLIDCEFLSAPITVIYAVYPALDPLPCLFFVDNYRNFI 316
Cdd:pfam10326 240 QLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAI 306
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
10-316 1.26e-109

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 322.10  E-value: 1.26e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542116    10 KTLIQLISYCFALTSNTLLIFLIVTKSPKKMGTYRSLMCYFCIISLIFTTLDVIVKPNIYSRESAFFMMMDLRNRMLPRY 89
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542116    90 IEECLMSVLCGCCGMAIYGIAIHFVYRYFALERQGRLRFFKGAYQIFWFFIPIFGCLNWTFIAGYFFAMNPISTGYIAPM 169
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542116   170 IEEMYNISINDAAYSAAVFWPPNEQGVVEFHWRSGLGLINLVTSMSLSLSVVIYTGVKSLKKIKQLLGrLESKFSKNLQM 249
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKS-LGSEKTRKLQK 239
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17542116   250 QLYKALVAQTLIPVLFIFIPFGILFTCPLFLIDCEFLSAPITVIYAVYPALDPLPCLFFVDNYRNFI 316
Cdd:pfam10326 240 QLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAI 306
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
10-316 1.26e-109

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 322.10  E-value: 1.26e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542116    10 KTLIQLISYCFALTSNTLLIFLIVTKSPKKMGTYRSLMCYFCIISLIFTTLDVIVKPNIYSRESAFFMMMDLRNRMLPRY 89
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542116    90 IEECLMSVLCGCCGMAIYGIAIHFVYRYFALERQGRLRFFKGAYQIFWFFIPIFGCLNWTFIAGYFFAMNPISTGYIAPM 169
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542116   170 IEEMYNISINDAAYSAAVFWPPNEQGVVEFHWRSGLGLINLVTSMSLSLSVVIYTGVKSLKKIKQLLGrLESKFSKNLQM 249
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKS-LGSEKTRKLQK 239
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17542116   250 QLYKALVAQTLIPVLFIFIPFGILFTCPLFLIDCEFLSAPITVIYAVYPALDPLPCLFFVDNYRNFI 316
Cdd:pfam10326 240 QLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAI 306
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
13-316 1.04e-33

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 126.20  E-value: 1.04e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542116    13 IQLISYCFALTSNTLLIFLIVTKSPKKMGTYRSLMCYFCIISLIFTTLDVIVKPNIYSRESAFFMMmdLRNRMLPRYIE- 91
Cdd:pfam10319  10 IPKIFGVLSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVF--VSDGPFFEYSEl 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542116    92 -ECLMSVLCGCCGMAiYGI-AIHFVYRYFALERQGRL-RFFKGAYQIFWFFIPIFGCLNWTFIAGYFFAMNPISTGYIAP 168
Cdd:pfam10319  88 gQHALSARCSFISAS-YAVlLIHFIYRYLVLFNPQLTrHYFRPWGILISILFFLFHGSVWTAICYFLLRANDEIRDYIRE 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542116   169 MIEEMYNISINDAAYSAAVFWppneQGVVEFHWRSGLGLInLVTSMS-LSLSVVIYTGVKSLKKIKQLLGRLeSKFSKNL 247
Cdd:pfam10319 167 DFRETYGVDSMDINMLGALYW----EASDETVFRSWLGIL-LLTVISvYSIILYIVLGYKIMRKLNKMSVTM-SKKTKRL 240
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542116   248 QMQLYKALVAQTLIPVLFIFIPFGILFTCPLFLIDCEFLSAPITVI-YAVYPALDPLPCLFFVDNYRNFI 316
Cdd:pfam10319 241 QKQLLKALIVQTIIPICISFSPCVLAWYSPIFGIDLGRWNNYLEVIaLSAFPFIDPLAIILCLPVYRNRI 310
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
16-316 1.76e-12

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 66.80  E-value: 1.76e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542116    16 ISYCFALTSNTLLIFLIVTKSPKKMGTYRSLMCYFCIISLIFTTLDVIVKPNIYSRESAFFMMMDLRNRMLPRYIEECLM 95
Cdd:pfam10317   7 IFFILGLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQRIIPNGVSMALISYGPCKYFGPWFCYSGY 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542116    96 SVLCGCCGMAIYGIAIHFVYRYFALeRQGRLRFFKGAYQIFWFFIPIFGCLNWTFIAGYFFAMNPISTGYIAPMI-EEMY 174
Cdd:pfam10317  87 SLLQHFLLHSGWSLLLTFYYRYYIL-KHVDPKRKKLILLIIIHYIPSLSQLIVIFLSPTDFLPVEALTKELHPNYnLTDY 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542116   175 NISINDAAysaavfwppneqgvveFHWRSGLGLINLVTSMSLSLSVVIYTGVKSLKKIKQLLGRLeSKFSKNLQMQLYKA 254
Cdd:pfam10317 166 TVTGFSDL----------------QSFPALINTLIMTIPVFPIPIIILILRRKILKLLNSNSVNM-SPTTKAQHRQLIKG 228
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17542116   255 LVAQTLIPVLFIFIPFGILFTCPLFLIDCEFLSAPITVIYAVYPALDPLPCLFFVDNYRNFI 316
Cdd:pfam10317 229 LTIQALLPLFSYIPGVTLYLLSQLTGTEFLILEYFIFVLPALPPLLDPLITIYFVTPYRRAI 290
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH