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Conserved domains on  [gi|17540062|ref|NP_500612|]
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Protein-lysine N-methyltransferase CELE_F29B9.1 [Caenorhabditis elegans]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 106779)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Methyltransf_31 super family cl48233
Methyltransferase domain; This family appears to have methyltransferase activity.
 62-186 2.57e-10

Methyltransferase domain; This family appears to have methyltransferase activity.


The actual alignment was detected with superfamily member pfam13847:

Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 57.04  E-value: 2.57e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540062    62 GKDAKILDLGCGNGSVLRKLRSKGFQSLK--GVDYCQKAvdLSAAASKAEREEeedeeLVDIEFEQLDITTPPADFFSSK 139
Cdd:pfam13847   2 DKGMRVLDLGCGTGHLSFELAEELGPNAEvvGIDISEEA--IEKARENAQKLG-----FDNVEFEQGDIEELPELLEDDK 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 17540062   140 FDVILDKGTWDAMSLSDerearlKAYLGFLDNgLSAGGRFVIFSCNF 186
Cdd:pfam13847  75 FDVVISNCVLNHIPDPD------KVLQEILRV-LKPGGRLIISDPDS 114
 
Name Accession Description Interval E-value
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 62-186 2.57e-10

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 57.04  E-value: 2.57e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540062    62 GKDAKILDLGCGNGSVLRKLRSKGFQSLK--GVDYCQKAvdLSAAASKAEREEeedeeLVDIEFEQLDITTPPADFFSSK 139
Cdd:pfam13847   2 DKGMRVLDLGCGTGHLSFELAEELGPNAEvvGIDISEEA--IEKARENAQKLG-----FDNVEFEQGDIEELPELLEDDK 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 17540062   140 FDVILDKGTWDAMSLSDerearlKAYLGFLDNgLSAGGRFVIFSCNF 186
Cdd:pfam13847  75 FDVVISNCVLNHIPDPD------KVLQEILRV-LKPGGRLIISDPDS 114
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 49-181 4.20e-10

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 55.79  E-value: 4.20e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540062  49 ETRIVKYlIDSKTGKDAKILDLGCGNGSVLRKLRSKGFQSLkGVDYCQKAVDLsaAASKAEReeeedeelVDIEFEQLDI 128
Cdd:COG2227  11 DRRLAAL-LARLLPAGGRVLDVGCGTGRLALALARRGADVT-GVDISPEALEI--ARERAAE--------LNVDFVQGDL 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 17540062 129 TTppADFFSSKFDVILdkgTWDAMslsdEREARLKAYLGFLDNGLSAGGRFVI 181
Cdd:COG2227  79 ED--LPLEDGSFDLVI---CSEVL----EHLPDPAALLRELARLLKPGGLLLL 122
PTZ00098 PTZ00098
phosphoethanolamine N-methyltransferase; Provisional
 35-173 2.25e-05

phosphoethanolamine N-methyltransferase; Provisional


Pssm-ID: 173391 [Multi-domain]  Cd Length: 263  Bit Score: 44.19  E-value: 2.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540062   35 QHGDEG----EVWFGTS--SETRIV---KYLIDSKTGKDAKILDLGCGNGSVLRKLRSKGFQSLKGVDYCQKAVDLSAAA 105
Cdd:PTZ00098  15 QYSDEGikayEFIFGEDyiSSGGIEattKILSDIELNENSKVLDIGSGLGGGCKYINEKYGAHVHGVDICEKMVNIAKLR 94

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17540062  106 SKAEREeeedeelvdIEFEQLDITTppADFFSSKFDVILDKGTWDAMSLSDEREARLKAYLGFLDNGL 173
Cdd:PTZ00098  95 NSDKNK---------IEFEANDILK--KDFPENTFDMIYSRDAILHLSYADKKKLFEKCYKWLKPNGI 151
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 66-181 1.50e-03

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 37.02  E-value: 1.50e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540062  66 KILDLGCGNGSVLRKLRSKGFQSLKGVDYCQKAVDLSAAASKAEREeeedeelVDIEFEQLDITTPPADFFSSkFDVILd 145
Cdd:cd02440   1 RVLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAALLA-------DNVEVLKGDAEELPPEADES-FDVII- 71

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 17540062 146 kgTWDAMSLSDEREARLkayLGFLDNGLSAGGRFVI 181
Cdd:cd02440  72 --SDPPLHHLVEDLARF---LEEARRLLKPGGVLVL 102
 
Name Accession Description Interval E-value
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 62-186 2.57e-10

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 57.04  E-value: 2.57e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540062    62 GKDAKILDLGCGNGSVLRKLRSKGFQSLK--GVDYCQKAvdLSAAASKAEREEeedeeLVDIEFEQLDITTPPADFFSSK 139
Cdd:pfam13847   2 DKGMRVLDLGCGTGHLSFELAEELGPNAEvvGIDISEEA--IEKARENAQKLG-----FDNVEFEQGDIEELPELLEDDK 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 17540062   140 FDVILDKGTWDAMSLSDerearlKAYLGFLDNgLSAGGRFVIFSCNF 186
Cdd:pfam13847  75 FDVVISNCVLNHIPDPD------KVLQEILRV-LKPGGRLIISDPDS 114
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 49-181 4.20e-10

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 55.79  E-value: 4.20e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540062  49 ETRIVKYlIDSKTGKDAKILDLGCGNGSVLRKLRSKGFQSLkGVDYCQKAVDLsaAASKAEReeeedeelVDIEFEQLDI 128
Cdd:COG2227  11 DRRLAAL-LARLLPAGGRVLDVGCGTGRLALALARRGADVT-GVDISPEALEI--ARERAAE--------LNVDFVQGDL 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 17540062 129 TTppADFFSSKFDVILdkgTWDAMslsdEREARLKAYLGFLDNGLSAGGRFVI 181
Cdd:COG2227  79 ED--LPLEDGSFDLVI---CSEVL----EHLPDPAALLRELARLLKPGGLLLL 122
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 63-181 5.23e-10

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 57.23  E-value: 5.23e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540062  63 KDAKILDLGCGNGSVLRKLRSKGFQSLKGVDYCQKAVDL-SAAASKAereeeedeELVDIEFEQLDITTPPaDFFSSKFD 141
Cdd:COG0500  26 KGGRVLDLGCGTGRNLLALAARFGGRVIGIDLSPEAIALaRARAAKA--------GLGNVEFLVADLAELD-PLPAESFD 96

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 17540062 142 VILdkgtwDAMSLSDEREARLKAYLGFLDNGLSAGGRFVI 181
Cdd:COG0500  97 LVV-----AFGVLHHLPPEEREALLRELARALKPGGVLLL 131
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 67-160 1.36e-09

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 53.72  E-value: 1.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540062    67 ILDLGCGNGSVLRKLRSKGFQSLKGVDYCQKAVDLsaAASKAEREEeedeelVDIEFEQLDITTPPadFFSSKFDVILDK 146
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEMLER--ARERAAEAG------LNVEFVQGDAEDLP--FPDGSFDLVVSS 70

                          90
                  ....*....|....
gi 17540062   147 GTWDAMSLSDEREA 160
Cdd:pfam13649  71 GVLHHLPDPDLEAA 84
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
62-185 1.76e-09

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 55.39  E-value: 1.76e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540062  62 GKDAKILDLGCGNGSVLRKLRSKGFqSLKGVDYCQKAVDLsaAASKAereeeedeelVDIEFEQLDITTPPAdfFSSKFD 141
Cdd:COG4976  45 GPFGRVLDLGCGTGLLGEALRPRGY-RLTGVDLSEEMLAK--AREKG----------VYDRLLVADLADLAE--PDGRFD 109

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 17540062 142 VILdkgTWDAMSLSDErearLKAYLGFLDNGLSAGGRFvIFSCN 185
Cdd:COG4976 110 LIV---AADVLTYLGD----LAAVFAGVARALKPGGLF-IFSVE 145
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
63-181 2.47e-08

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 50.21  E-value: 2.47e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540062  63 KDAKILDLGCGNGSVLRKL--RSKGFQSLkGVDYCQKAVDLSAAAskaereeeedeeLVDIEFEQLDITTPPADffsSKF 140
Cdd:COG4106   1 PPRRVLDLGCGTGRLTALLaeRFPGARVT-GVDLSPEMLARARAR------------LPNVRFVVADLRDLDPP---EPF 64

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 17540062 141 DVILdkgTWDAMSLSDEREARLKAylgfLDNGLSAGGRFVI 181
Cdd:COG4106  65 DLVV---SNAALHWLPDHAALLAR----LAAALAPGGVLAV 98
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 63-196 1.96e-06

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 46.14  E-value: 1.96e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540062  63 KDAKILDLGCGNGSVLRKLRSKGFQSLkGVDYCQKAVDLsaAASKAEREEeedeelVDIEFEQLDITTPPadFFSSKFDV 142
Cdd:COG2226  22 PGARVLDLGCGTGRLALALAERGARVT-GVDISPEMLEL--ARERAAEAG------LNVEFVVGDAEDLP--FPDGSFDL 90

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17540062 143 ILDKGTWdaMSLSDEREA-----RLkaylgfldngLSAGGRFVIFSCN----FTFDEMCSQFG 196
Cdd:COG2226  91 VISSFVL--HHLPDPERAlaeiaRV----------LKPGGRLVVVDFSppdlAELEELLAEAG 141
PTZ00098 PTZ00098
phosphoethanolamine N-methyltransferase; Provisional
 35-173 2.25e-05

phosphoethanolamine N-methyltransferase; Provisional


Pssm-ID: 173391 [Multi-domain]  Cd Length: 263  Bit Score: 44.19  E-value: 2.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540062   35 QHGDEG----EVWFGTS--SETRIV---KYLIDSKTGKDAKILDLGCGNGSVLRKLRSKGFQSLKGVDYCQKAVDLSAAA 105
Cdd:PTZ00098  15 QYSDEGikayEFIFGEDyiSSGGIEattKILSDIELNENSKVLDIGSGLGGGCKYINEKYGAHVHGVDICEKMVNIAKLR 94

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17540062  106 SKAEREeeedeelvdIEFEQLDITTppADFFSSKFDVILDKGTWDAMSLSDEREARLKAYLGFLDNGL 173
Cdd:PTZ00098  95 NSDKNK---------IEFEANDILK--KDFPENTFDMIYSRDAILHLSYADKKKLFEKCYKWLKPNGI 151
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 65-181 3.58e-05

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 42.61  E-value: 3.58e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540062  65 AKILDLGCGNGSVLRKL-RSKGFQslkgVDycqkAVDLSAAASKAEREEEEDEELVD-IEFEQLDITTPPADffsSKFDV 142
Cdd:COG2230  53 MRVLDIGCGWGGLALYLaRRYGVR----VT----GVTLSPEQLEYARERAAEAGLADrVEVRLADYRDLPAD---GQFDA 121

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 17540062 143 ILDKGTWDAMslsdeREARLKAYLGFLDNGLSAGGRFVI 181
Cdd:COG2230 122 IVSIGMFEHV-----GPENYPAYFAKVARLLKPGGRLLL 155
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 68-144 4.97e-05

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 41.20  E-value: 4.97e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17540062    68 LDLGCGNGSVLRKLrskgFQSLKGVDYCqkAVDLSAAASKAEREEEEDEELVDIEFEQLDiTTPPADFFSSKFDVIL 144
Cdd:pfam08242   1 LEIGCGTGTLLRAL----LEALPGLEYT--GLDISPAALEAARERLAALGLLNAVRVELF-QLDLGELDPGSFDVVV 70
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 68-144 2.76e-04

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 38.80  E-value: 2.76e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17540062    68 LDLGCGNGSVLRKLRSKGFQsLKGVDYCQKAVDLSAAASKAereeeedeelVDIEFEQLDITTPPadFFSSKFDVIL 144
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGAR-VTGVDISPEMLELAREKAPR----------EGLTFVVGDAEDLP--FPDNSFDLVL 64
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 63-181 4.53e-04

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 40.13  E-value: 4.53e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540062  63 KDAKILDLGCGNGSVLrkL----RSKGfQSLKGVDYCQKAVDL---SAAASKaereeeedeeLVD-IEFEQLDITTPPAD 134
Cdd:COG4123  37 KGGRVLDLGTGTGVIA--LmlaqRSPG-ARITGVEIQPEAAELarrNVALNG----------LEDrITVIHGDLKEFAAE 103

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 17540062 135 FFSSKFDVIL-----DKGTWDAMSLSDERE-AR------LKAYLGFLDNGLSAGGRFVI 181
Cdd:COG4123 104 LPPGSFDLVVsnppyFKAGSGRKSPDEARAiARhedaltLEDLIRAAARLLKPGGRFAL 162
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 66-181 1.50e-03

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 37.02  E-value: 1.50e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540062  66 KILDLGCGNGSVLRKLRSKGFQSLKGVDYCQKAVDLSAAASKAEREeeedeelVDIEFEQLDITTPPADFFSSkFDVILd 145
Cdd:cd02440   1 RVLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAALLA-------DNVEVLKGDAEELPPEADES-FDVII- 71

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 17540062 146 kgTWDAMSLSDEREARLkayLGFLDNGLSAGGRFVI 181
Cdd:cd02440  72 --SDPPLHHLVEDLARF---LEEARRLLKPGGVLVL 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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