NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|193207011|ref|NP_500584|]
View 

Prion-like-(Q/N-rich)-domain-bearing protein [Caenorhabditis elegans]

Protein Classification

atrophin-1 family protein( domain architecture ID 1002132)

atrophin-1 family protein similar to Homo sapiens atrophin-1 which acts as a transcriptional corepressor that recruits NR2E1 to repress transcription

Gene Ontology:  GO:0140110|GO:0005515

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PRK10263 super family cl35903
DNA translocase FtsK; Provisional
 279-442 7.60e-06

DNA translocase FtsK; Provisional


The actual alignment was detected with superfamily member PRK10263:

Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 49.70  E-value: 7.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011  279 TPYPKQVAVETAA--PFVPQPVRPAPQPVQPSFQPAPAVQQQVHQVFTTPIPHRPFVPETFVEQVEAGQANLVPAPVQPQ 356
Cdd:PRK10263  341 TQTPPVASVDVPPaqPTVAWQPVPGPQTGEPVIAPAPEGYPQQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPY 420

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011  357 PYVAPAHITQEIQPAPQPYVAPVAPVAQEIHTIQPIQPAPIH-PAPLQPAHVVQETAHVAPEtkVVAEEDRIEVSGGSDY 435
Cdd:PRK10263  421 YAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYqTEQTYQQPAAQEPLYQQPQ--PVEQQPVVEPEPVVEE 498


                  ....*..
gi 193207011  436 DQPSNIP 442
Cdd:PRK10263  499 TKPARPP 505
Atrophin-1 super family cl38111
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 214-588 2.98e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


The actual alignment was detected with superfamily member pfam03154:

Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 47.45  E-value: 2.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011  214 AQPQVQQHRPAASSSSSSSSSSASAEHHPTHQVRVPSASSSIESNEQRVVPESVIVKEIVQTFETTPYPKQVAVETAAPF 293
Cdd:pfam03154 162 AQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQR 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011  294 VPQP---VRPAPQPVQPSFQPAPAVQQQVHQVFTTPIPH----------RPFVPETFVEQVEAGQANLVPAPVQPQPYVA 360
Cdd:pfam03154 242 LPSPhppLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHslqtgpshmqHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQS 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011  361 PAHITQ-----EIQPAPQPYVAPVAPVAQEIHTIQPIQPAPIHPAPLQPAHvvQETAHvapetkvvaeedrieVSGGSDY 435
Cdd:pfam03154 322 QQRIHTppsqsQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSH--KHPPH---------------LSGPSPF 384

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011  436 DQPSNIPANEQAtvnELLATLDNTTPAS------NLDFNQVTVEPNTNQKPAIIQTEG--DDYDTAPLNEDRKDVPTAEP 507
Cdd:pfam03154 385 QMNSNLPPPPAL---KPLSSLSTHHPPSahppplQLMPQSQQLPPPPAQPPVLTQSQSlpPPAASHPPTSGLHQVPSQSP 461

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011  508 --SHNVAPSNPEPVAVIPEETAPIIPQPKPKPQVHLQPVAPAVRVEVTSSAPAPTIAF--ELPIEVHEVVTPQVPL---N 580
Cdd:pfam03154 462 fpQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPVQIkeEALDEAEEPESPPPPPrspS 541


                  ....*...
gi 193207011  581 PEPAVIQT 588
Cdd:pfam03154 542 PEPTVVNT 549
 
Name Accession Description Interval E-value
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 279-442 7.60e-06

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 49.70  E-value: 7.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011  279 TPYPKQVAVETAA--PFVPQPVRPAPQPVQPSFQPAPAVQQQVHQVFTTPIPHRPFVPETFVEQVEAGQANLVPAPVQPQ 356
Cdd:PRK10263  341 TQTPPVASVDVPPaqPTVAWQPVPGPQTGEPVIAPAPEGYPQQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPY 420

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011  357 PYVAPAHITQEIQPAPQPYVAPVAPVAQEIHTIQPIQPAPIH-PAPLQPAHVVQETAHVAPEtkVVAEEDRIEVSGGSDY 435
Cdd:PRK10263  421 YAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYqTEQTYQQPAAQEPLYQQPQ--PVEQQPVVEPEPVVEE 498


                  ....*..
gi 193207011  436 DQPSNIP 442
Cdd:PRK10263  499 TKPARPP 505
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 214-588 2.98e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 47.45  E-value: 2.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011  214 AQPQVQQHRPAASSSSSSSSSSASAEHHPTHQVRVPSASSSIESNEQRVVPESVIVKEIVQTFETTPYPKQVAVETAAPF 293
Cdd:pfam03154 162 AQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQR 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011  294 VPQP---VRPAPQPVQPSFQPAPAVQQQVHQVFTTPIPH----------RPFVPETFVEQVEAGQANLVPAPVQPQPYVA 360
Cdd:pfam03154 242 LPSPhppLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHslqtgpshmqHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQS 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011  361 PAHITQ-----EIQPAPQPYVAPVAPVAQEIHTIQPIQPAPIHPAPLQPAHvvQETAHvapetkvvaeedrieVSGGSDY 435
Cdd:pfam03154 322 QQRIHTppsqsQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSH--KHPPH---------------LSGPSPF 384

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011  436 DQPSNIPANEQAtvnELLATLDNTTPAS------NLDFNQVTVEPNTNQKPAIIQTEG--DDYDTAPLNEDRKDVPTAEP 507
Cdd:pfam03154 385 QMNSNLPPPPAL---KPLSSLSTHHPPSahppplQLMPQSQQLPPPPAQPPVLTQSQSlpPPAASHPPTSGLHQVPSQSP 461

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011  508 --SHNVAPSNPEPVAVIPEETAPIIPQPKPKPQVHLQPVAPAVRVEVTSSAPAPTIAF--ELPIEVHEVVTPQVPL---N 580
Cdd:pfam03154 462 fpQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPVQIkeEALDEAEEPESPPPPPrspS 541


                  ....*...
gi 193207011  581 PEPAVIQT 588
Cdd:pfam03154 542 PEPTVVNT 549
rne PRK10811
ribonuclease E; Reviewed
 353-567 7.90e-05

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 46.19  E-value: 7.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011  353 VQPQpyvapAHITQEIQPAPQPYVAPVAPVAQEIHTIQPIQPAPIHPAPLQPAHVVQETAHVAPETKVVAEEDRIEVSGG 432
Cdd:PRK10811  848 VRPQ-----DVQVEEQREAEEVQVQPVVAEVPVAAAVEPVVSAPVVEAVAEVVEEPVVVAEPQPEEVVVVETTHPEVIAA 922

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011  433 SDYDQPSNIPANEQATVNELLATLDNTTPASNLDFNQVTVEPNTNQKPAiiqtegddydtaplnEDRKDVPTAEPShnVA 512
Cdd:PRK10811  923 PVTEQPQVITESDVAVAQEVAEHAEPVVEPQDETADIEEAAETAEVVVA---------------EPEVVAQPAAPV--VA 985

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 193207011  513 PSNPEPVAVIPEETAPIIPQPKPKPQVHLQPVAPAVRvevtssAPAPTIAFELPI 567
Cdd:PRK10811  986 EVAAEVETVTAVEPEVAPAQVPEATVEHNHATAPMTR------APAPEYVPEAPR 1034
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 291-409 7.54e-04

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 42.72  E-value: 7.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011  291 APFVPQPVRPAPQPVQPSFQPAPAVQQQVHQVFTTPIPHRPFVPetfveqveagqanlvpaPVQPQPYVAPAHITQEIQ- 369
Cdd:pfam09770 209 KPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQ-----------------PQQHPGQGHPVTILQRPQs 271

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 193207011  370 PAPQPYVAPVAPVAQEIHTIQPiqpapihPAPLQPAHVVQ 409
Cdd:pfam09770 272 PQPDPAQPSIQPQAQQFHQQPP-------PVPVQPTQILQ 304
 
Name Accession Description Interval E-value
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 279-442 7.60e-06

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 49.70  E-value: 7.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011  279 TPYPKQVAVETAA--PFVPQPVRPAPQPVQPSFQPAPAVQQQVHQVFTTPIPHRPFVPETFVEQVEAGQANLVPAPVQPQ 356
Cdd:PRK10263  341 TQTPPVASVDVPPaqPTVAWQPVPGPQTGEPVIAPAPEGYPQQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPY 420

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011  357 PYVAPAHITQEIQPAPQPYVAPVAPVAQEIHTIQPIQPAPIH-PAPLQPAHVVQETAHVAPEtkVVAEEDRIEVSGGSDY 435
Cdd:PRK10263  421 YAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYqTEQTYQQPAAQEPLYQQPQ--PVEQQPVVEPEPVVEE 498


                  ....*..
gi 193207011  436 DQPSNIP 442
Cdd:PRK10263  499 TKPARPP 505
rne PRK10811
ribonuclease E; Reviewed
 249-439 1.35e-05

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 48.50  E-value: 1.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011  249 PSASSSIESNEQRVVPESVIVKEIVQTFETTPYPKQVAVETAAPFVPQPVRPAPqPVQPSFQPAPAVQQqvhQVFTTPIP 328
Cdd:PRK10811  850 PQDVQVEEQREAEEVQVQPVVAEVPVAAAVEPVVSAPVVEAVAEVVEEPVVVAE-PQPEEVVVVETTHP---EVIAAPVT 925

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011  329 HRPFV----PETFVEQVEAGQANLVPAPVQPQPYVAPAHITQEIQPAPQPYVAPVAPVAQEIHtiQPIQPAPIHPAPLQP 404
Cdd:PRK10811  926 EQPQVitesDVAVAQEVAEHAEPVVEPQDETADIEEAAETAEVVVAEPEVVAQPAAPVVAEVA--AEVETVTAVEPEVAP 1003

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 193207011  405 AHVVQETAHV----APETKVVAEEDRIEVSGGSDYDQPS 439
Cdd:PRK10811 1004 AQVPEATVEHnhatAPMTRAPAPEYVPEAPRHSDWQRPT 1042
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 214-588 2.98e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 47.45  E-value: 2.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011  214 AQPQVQQHRPAASSSSSSSSSSASAEHHPTHQVRVPSASSSIESNEQRVVPESVIVKEIVQTFETTPYPKQVAVETAAPF 293
Cdd:pfam03154 162 AQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQR 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011  294 VPQP---VRPAPQPVQPSFQPAPAVQQQVHQVFTTPIPH----------RPFVPETFVEQVEAGQANLVPAPVQPQPYVA 360
Cdd:pfam03154 242 LPSPhppLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHslqtgpshmqHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQS 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011  361 PAHITQ-----EIQPAPQPYVAPVAPVAQEIHTIQPIQPAPIHPAPLQPAHvvQETAHvapetkvvaeedrieVSGGSDY 435
Cdd:pfam03154 322 QQRIHTppsqsQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSH--KHPPH---------------LSGPSPF 384

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011  436 DQPSNIPANEQAtvnELLATLDNTTPAS------NLDFNQVTVEPNTNQKPAIIQTEG--DDYDTAPLNEDRKDVPTAEP 507
Cdd:pfam03154 385 QMNSNLPPPPAL---KPLSSLSTHHPPSahppplQLMPQSQQLPPPPAQPPVLTQSQSlpPPAASHPPTSGLHQVPSQSP 461

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011  508 --SHNVAPSNPEPVAVIPEETAPIIPQPKPKPQVHLQPVAPAVRVEVTSSAPAPTIAF--ELPIEVHEVVTPQVPL---N 580
Cdd:pfam03154 462 fpQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPVQIkeEALDEAEEPESPPPPPrspS 541


                  ....*...
gi 193207011  581 PEPAVIQT 588
Cdd:pfam03154 542 PEPTVVNT 549
rne PRK10811
ribonuclease E; Reviewed
 353-567 7.90e-05

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 46.19  E-value: 7.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011  353 VQPQpyvapAHITQEIQPAPQPYVAPVAPVAQEIHTIQPIQPAPIHPAPLQPAHVVQETAHVAPETKVVAEEDRIEVSGG 432
Cdd:PRK10811  848 VRPQ-----DVQVEEQREAEEVQVQPVVAEVPVAAAVEPVVSAPVVEAVAEVVEEPVVVAEPQPEEVVVVETTHPEVIAA 922

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011  433 SDYDQPSNIPANEQATVNELLATLDNTTPASNLDFNQVTVEPNTNQKPAiiqtegddydtaplnEDRKDVPTAEPShnVA 512
Cdd:PRK10811  923 PVTEQPQVITESDVAVAQEVAEHAEPVVEPQDETADIEEAAETAEVVVA---------------EPEVVAQPAAPV--VA 985

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 193207011  513 PSNPEPVAVIPEETAPIIPQPKPKPQVHLQPVAPAVRvevtssAPAPTIAFELPI 567
Cdd:PRK10811  986 EVAAEVETVTAVEPEVAPAQVPEATVEHNHATAPMTR------APAPEYVPEAPR 1034
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 205-392 1.32e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 45.46  E-value: 1.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011  205 EQQATQTHHAQPQVQQHRPAASSSSSSSSSSASAEHHPTHQVRVPSASSSIESNEQRVVPESVIVKEIVQTFET--TPYP 282
Cdd:PRK10263  378 EGYPQQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEqqSTFA 457

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011  283 KQVAVETAAPFvPQPVRPAPQPVQPSFQPAPAVQQQVHQVFTTPiPHRPfvPETFVEQVEAGQA---NLVPAPVQPQPyv 359
Cdd:PRK10263  458 PQSTYQTEQTY-QQPAAQEPLYQQPQPVEQQPVVEPEPVVEETK-PARP--PLYYFEEVEEKRArerEQLAAWYQPIP-- 531

                         170       180       190
                  ....*....|....*....|....*....|...
gi 193207011  360 APAHITQEIQPAPQPYVAPVAPVAQEIHTIQPI 392
Cdd:PRK10263  532 EPVKEPEPIKSSLKAPSVAAVPPVEAAAAVSPL 564
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 244-416 2.32e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 44.69  E-value: 2.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011  244 HQVRVPSASSSIESNEQRVVP---ESVIVKEIVQTFETTPYPKQVAVETA-APFVPQPV--------RPAPQPVQPSF-- 309
Cdd:PRK10263  314 APITEPVAVAAAATTATQSWAapvEPVTQTPPVASVDVPPAQPTVAWQPVpGPQTGEPViapapegyPQQSQYAQPAVqy 393

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011  310 -----QPAPAVQQQVHQVFTTPIPHRPFVPETFVEQVEAGQANLVPAPVQPQPYVA-PAHITQEIQPAPQPYVAPVAPVA 383
Cdd:PRK10263  394 neplqQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAeEQQSTFAPQSTYQTEQTYQQPAA 473

                         170       180       190
                  ....*....|....*....|....*....|...
gi 193207011  384 QEIHTIQPiqPAPIHPAPLQPAHVVQETAHVAP 416
Cdd:PRK10263  474 QEPLYQQP--QPVEQQPVVEPEPVVEETKPARP 504
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 282-431 3.80e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 43.70  E-value: 3.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011 282 PKQVAVETAAPFVPQPVRPAPQPVQPSFQPAPAVQQQVHQVFTTPIPHRPFVPETFVEQVEAGQANLVPAPVQPQPYVAP 361
Cdd:PRK07994 385 AAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQRAQGATKAKKSEPAAASRARPVNSALERLASVRP 464

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 193207011 362 AHITQEIQPAPQPYVAPVAPVAQEIHTIQPIQPAPIHPAPLQP--AHVVQETAHVAPETKVVAEE-DRIEVSG 431
Cdd:PRK07994 465 APSALEKAPAKKEAYRWKATNPVEVKKEPVATPKALKKALEHEktPELAAKLAAEAIERDPWAALvSQLGLPG 537
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 293-424 6.30e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 42.93  E-value: 6.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011 293 FVPQPVRPAPQPVQPSFQPAPAVQQQVHQVfttpiphrpfvpetfvEQVEAGQANLVPAPVQPQPYVAPAhiTQEIQPAP 372
Cdd:PRK07994 359 FHPAAPLPEPEVPPQSAAPAASAQATAAPT----------------AAVAPPQAPAVPPPPASAPQQAPA--VPLPETTS 420

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 193207011 373 QPYVAPVAPVAQEIHTiQPIQPAPIHPAPLQPAHVVQET-AHVAPETKVVAEE 424
Cdd:PRK07994 421 QLLAARQQLQRAQGAT-KAKKSEPAAASRARPVNSALERlASVRPAPSALEKA 472
PHA03378 PHA03378
EBNA-3B; Provisional
 256-584 6.31e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 43.13  E-value: 6.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011 256 ESNEQRVVPESVIVKEIVQTFETTPYPKQVAVETA-APFVPQPVRPAPQ--PV---QPSFQPAPA--------------V 315
Cdd:PHA03378 437 RTEQPRATPHSQAPTVVLHRPPTQPLEGPTGPLSVqAPLEPWQPLPHPQvtPVilhQPPAQGVQAhgsmldllekddedM 516

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011 316 QQQVHQVFTTPIPHRP---------FVPETFVEQVEAGQANLV---------PAPVQPQPYVAP--AHI-------TQEI 368
Cdd:PHA03378 517 EQRVMATLLPPSPPQPragrrapcvYTEDLDIESDEPASTEPVhdqllpapgLGPLQIQPLTSPttSQLassapsyAQTP 596

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011 369 QPAPQPYVAPVAPVAQEI--------HTIQPIQPAPIHPAPLQPA---HVVQETAHVAPETKVVAEEDRIEVSGGSDYdQ 437
Cdd:PHA03378 597 WPVPHPSQTPEPPTTQSHipetsaprQWPMPLRPIPMRPLRMQPItfnVLVFPTPHQPPQVEITPYKPTWTQIGHIPY-Q 675

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011 438 PSNIPANEQATVNELLATLdNTTPASNLDFNQVTVEPNTNQKPAIIQTEGDDYDTAPLNEDR-KDVPTAEPSHNVAPSNP 516
Cdd:PHA03378 676 PSPTGANTMLPIQWAPGTM-QPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPpAAAPGRARPPAAAPGRA 754

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 193207011 517 EPVAVIPEETAPIIPQPKPKPQVHlQPVAPAVRVEVTSSAPAPTIAFELPIEVHEVVTPQVPLNPEPA 584
Cdd:PHA03378 755 RPPAAAPGRARPPAAAPGAPTPQP-PPQAPPAPQQRPRGAPTPQPPPQAGPTSMQLMPRAAPGQQGPT 821
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 279-412 7.25e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.78  E-value: 7.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011 279 TPYPKQVAVETAAPFVPQPVRPAPQPVQPSFQPAPAVQQqvhqvftTPIPHRPFVPETFVEQVEAGQANLVPAPVQPQPY 358
Cdd:PRK14951 380 TPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPP-------AAAPPAPVAAPAAAAPAAAPAAAPAAVALAPAPP 452

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 193207011 359 VAPAHITQEIQPAPQPyvAPVAPVAQEIHTIQPiQPAPIHPAPLQP---AHVVQETA 412
Cdd:PRK14951 453 AQAAPETVAIPVRVAP--EPAVASAAPAPAAAP-AAARLTPTEEGDvwhATVQQLAA 506
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 291-409 7.54e-04

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 42.72  E-value: 7.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011  291 APFVPQPVRPAPQPVQPSFQPAPAVQQQVHQVFTTPIPHRPFVPetfveqveagqanlvpaPVQPQPYVAPAHITQEIQ- 369
Cdd:pfam09770 209 KPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQ-----------------PQQHPGQGHPVTILQRPQs 271

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 193207011  370 PAPQPYVAPVAPVAQEIHTIQPiqpapihPAPLQPAHVVQ 409
Cdd:pfam09770 272 PQPDPAQPSIQPQAQQFHQQPP-------PVPVQPTQILQ 304
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 282-426 8.44e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 42.55  E-value: 8.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011 282 PKQVAVETAAPfvPQPVRPAPQ---PVQPSFQPAPAVQQQVHQVFTTPIPHRPFV-PETFVEQVEAGQANLVPAPVQPQP 357
Cdd:PRK07994 361 PAAPLPEPEVP--PQSAAPAASaqaTAAPTAAVAPPQAPAVPPPPASAPQQAPAVpLPETTSQLLAARQQLQRAQGATKA 438

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 193207011 358 YVAPAHITQEIQPAPQPY--VAPVAPVAQEIhTIQPIQPAPIHPAPLQPAHVVQETAHVAPETKVVAEEDR 426
Cdd:PRK07994 439 KKSEPAAASRARPVNSALerLASVRPAPSAL-EKAPAKKEAYRWKATNPVEVKKEPVATPKALKKALEHEK 508
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 309-454 8.83e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.39  E-value: 8.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011 309 FQPAPAVQQQVHQVFTTPipHRPFVPETFVEQVEAGQANLVPAPVQPQPYVAPAHITQEIQPAPQPYVAPVAPVAQEIHT 388
Cdd:PRK14951 364 FKPAAAAEAAAPAEKKTP--ARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAA 441

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 193207011 389 IQPIQPAPIHPAPLQPaHVVQETAHVAPETKVVAEEDRIEVSGGSDYDQPSNIPANEQATVNELLA 454
Cdd:PRK14951 442 PAAVALAPAPPAQAAP-ETVAIPVRVAPEPAVASAAPAPAAAPAAARLTPTEEGDVWHATVQQLAA 506
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 297-409 5.06e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 40.02  E-value: 5.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011  297 PVRPAPQPVQPSFQPAPAVQQQVHQVFTTPIPHRPFVPetfveqveagQANLVPAPVQPQPYVAPAHITQEIQ----PAP 372
Cdd:pfam09770 208 KKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQ----------PQQQPQQPQQHPGQGHPVTILQRPQspqpDPA 277

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 193207011  373 QPYVAPVAPVAQEIHTIQPIQP-----------APIHPAPLQPAHVVQ 409
Cdd:pfam09770 278 QPSIQPQAQQFHQQPPPVPVQPtqilqnpnrlsAARVGYPQNPQPGVQ 325
rne PRK10811
ribonuclease E; Reviewed
 300-451 6.46e-03

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 40.02  E-value: 6.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011  300 PAPQPVQPSFQPAPAVQQQVHQVFTTPIPHRPFVPETFVEQVEAGQANLVPAPVQPQPYVAPAHITQEiqpAPQPYVApV 379
Cdd:PRK10811  846 PVVRPQDVQVEEQREAEEVQVQPVVAEVPVAAAVEPVVSAPVVEAVAEVVEEPVVVAEPQPEEVVVVE---TTHPEVI-A 921

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011  380 APVAQEIHTI---------------QPIQPAPIHPAPLQPAHVVQETAHVAPETKVVAEEDRIEVSGGSDYDQPSNIPAN 444
Cdd:PRK10811  922 APVTEQPQVItesdvavaqevaehaEPVVEPQDETADIEEAAETAEVVVAEPEVVAQPAAPVVAEVAAEVETVTAVEPEV 1001


                  ....*..
gi 193207011  445 EQATVNE 451
Cdd:PRK10811 1002 APAQVPE 1008
rne PRK10811
ribonuclease E; Reviewed
 503-659 6.80e-03

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 40.02  E-value: 6.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011  503 PTAEPSHNVAPSNPEPVAVIPEETAPIIPQPKPKPQVHLQPVAPAVRVEVTSSAP--APTIAFELPIEVHEVVTPQVPLN 580
Cdd:PRK10811  846 PVVRPQDVQVEEQREAEEVQVQPVVAEVPVAAAVEPVVSAPVVEAVAEVVEEPVVvaEPQPEEVVVVETTHPEVIAAPVT 925

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 193207011  581 PEPAVIqtiteQPVAEVHVEVLPTSAAPVSQFFENITSKEDKETSQPSETVETAPANGNDYDEEKSVENKVSTETDAVP 659
Cdd:PRK10811  926 EQPQVI-----TESDVAVAQEVAEHAEPVVEPQDETADIEEAAETAEVVVAEPEVVAQPAAPVVAEVAAEVETVTAVEP 999
PHA03247 PHA03247
large tegument protein UL36; Provisional
 280-641 8.15e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 8.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011  280 PYPKQVAVETAAP--FVPQPvRPAPQPvqpsfqPAPAVQQQVHQVFTTPIPHRPFVPetfveqveagQANLVPAPVQPQP 357
Cdd:PHA03247 2552 PPPLPPAAPPAAPdrSVPPP-RPAPRP------SEPAVTSRARRPDAPPQSARPRAP----------VDDRGDPRGPAPP 2614

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011  358 YVAPAHITQEIQPAPQPYVAPVAPVAQEIHTIQPIQPAPIHPAPlqpahvvqetAHVAPETKVVAEEDRIEVSGGSDYDQ 437
Cdd:PHA03247 2615 SPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAP----------GRVSRPRRARRLGRAAQASSPPQRPR 2684

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011  438 PSNIPAneqaTVNELLATLDNTTPASNLDFNQVTVEPNTNQKPAIiQTEGDDYDTAPLNEdrkdVPTAEPSHNVAPSNPE 517
Cdd:PHA03247 2685 RRAARP----TVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGP-AAARQASPALPAAP----APPAVPAGPATPGGPA 2755

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207011  518 PVAVIPEETAPIIpqpkpkpqvhlqPVAPAVRVevtssAPAPTIAFELPIEVHEVVTPQVPLNPEPAVIQTITEQPVAEV 597
Cdd:PHA03247 2756 RPARPPTTAGPPA------------PAPPAAPA-----AGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAAL 2818

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 193207011  598 HVEVLPTSAAPVSQFFENITSKEDKETSQPSETVETAPANGNDY 641
Cdd:PHA03247 2819 PPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDV 2862
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH