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Conserved domains on  [gi|17542118|ref|NP_500561|]
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Seven TM Receptor [Caenorhabditis elegans]

Protein Classification

class R serpentine receptor( domain architecture ID 10563422)

class R serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
11-320 4.33e-111

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402099  Cd Length: 307  Bit Score: 325.95  E-value: 4.33e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542118    11 LKIVQYTSAFMSVSLNCILIFLILAHSPKKLGMYKYLMIYISSFEALYSLWDVTTEPMVHSYKAAFVVFRNFKNSDFDRE 90
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542118    91 HSFILIVIYCGCFGFSLAIFGVHFVYRYGAVVKEFRDKWLGGKKIYILFFMPIFYGTWWSVLCYLYFHFDDSTDDYMRKT 170
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542118   171 IFDGYDTKIEDTSYIIVLFHPVDKNGTSHPDPAVFASIACMWFMILSSVFSVFFFGIKCYFRITEALSRTcnvSSVTKGL 250
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLG---SEKTRKL 237
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542118   251 QQQLFQALVVQTFIPLILMYIPIAILFTFPMIAVDIGFASSFVAMTIAVYPAIDPLPNMFIIKNYRKAVF 320
Cdd:pfam10326 238 QKQLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
11-320 4.33e-111

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 325.95  E-value: 4.33e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542118    11 LKIVQYTSAFMSVSLNCILIFLILAHSPKKLGMYKYLMIYISSFEALYSLWDVTTEPMVHSYKAAFVVFRNFKNSDFDRE 90
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542118    91 HSFILIVIYCGCFGFSLAIFGVHFVYRYGAVVKEFRDKWLGGKKIYILFFMPIFYGTWWSVLCYLYFHFDDSTDDYMRKT 170
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542118   171 IFDGYDTKIEDTSYIIVLFHPVDKNGTSHPDPAVFASIACMWFMILSSVFSVFFFGIKCYFRITEALSRTcnvSSVTKGL 250
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLG---SEKTRKL 237
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542118   251 QQQLFQALVVQTFIPLILMYIPIAILFTFPMIAVDIGFASSFVAMTIAVYPAIDPLPNMFIIKNYRKAVF 320
Cdd:pfam10326 238 QKQLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
11-320 4.33e-111

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 325.95  E-value: 4.33e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542118    11 LKIVQYTSAFMSVSLNCILIFLILAHSPKKLGMYKYLMIYISSFEALYSLWDVTTEPMVHSYKAAFVVFRNFKNSDFDRE 90
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542118    91 HSFILIVIYCGCFGFSLAIFGVHFVYRYGAVVKEFRDKWLGGKKIYILFFMPIFYGTWWSVLCYLYFHFDDSTDDYMRKT 170
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542118   171 IFDGYDTKIEDTSYIIVLFHPVDKNGTSHPDPAVFASIACMWFMILSSVFSVFFFGIKCYFRITEALSRTcnvSSVTKGL 250
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLG---SEKTRKL 237
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542118   251 QQQLFQALVVQTFIPLILMYIPIAILFTFPMIAVDIGFASSFVAMTIAVYPAIDPLPNMFIIKNYRKAVF 320
Cdd:pfam10326 238 QKQLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
8-319 1.53e-43

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 152.78  E-value: 1.53e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542118     8 NIFLKIVQYTSAFMSVSLNCILIFLILAHSPKKLGMYKYLMIYISSFEALYSLWDVTTEPMVHSYKAAFVVFRN----FK 83
Cdd:pfam10319   4 NWAHYYIPKIFGVLSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFVSdgpfFE 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542118    84 NSDFdrehSFILIVIYCGCFGFSLAIFGVHFVYRYGAVVK-EFRDKWLGGKKIYILFFMPIFYGTWWSVLCYLYFHFDDS 162
Cdd:pfam10319  84 YSEL----GQHALSARCSFISASYAVLLIHFIYRYLVLFNpQLTRHYFRPWGILISILFFLFHGSVWTAICYFLLRANDE 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542118   163 TDDYMRKTIFDGYDTKIEDTSYIIVLFHPVdkngtshPDPAVFASIACMWFMILSSVFSVFFFGIKCYFRITEALSRTCN 242
Cdd:pfam10319 160 IRDYIREDFRETYGVDSMDINMLGALYWEA-------SDETVFRSWLGILLLTVISVYSIILYIVLGYKIMRKLNKMSVT 232
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17542118   243 VSSVTKGLQQQLFQALVVQTFIPLILMYIPIAILFTFPMIAVDIGFASSFVAMT-IAVYPAIDPLPNMFIIKNYRKAV 319
Cdd:pfam10319 233 MSKKTKRLQKQLLKALIVQTIIPICISFSPCVLAWYSPIFGIDLGRWNNYLEVIaLSAFPFIDPLAIILCLPVYRNRI 310
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
19-319 2.66e-11

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 63.34  E-value: 2.66e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542118    19 AFMSVSLNCILIFLILAHSPKKLGMYKYLMIYISSFEALYSLWDVTTEPMVHSYKAAFVVFRNFKNSDFDREHSFILIVI 98
Cdd:pfam10317   9 FILGLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQRIIPNGVSMALISYGPCKYFGPWFCYSGYSL 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542118    99 YCGCFGFSLAIFGVHFVYRYgAVVKEFRDKWLGGKKIYILFFMPIFygtwwSVLCYLYFHFDDSTDDYMR-KTIFDGYDT 177
Cdd:pfam10317  89 LQHFLLHSGWSLLLTFYYRY-YILKHVDPKRKKLILLIIIHYIPSL-----SQLIVIFLSPTDFLPVEALtKELHPNYNL 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542118   178 KIEDTSYIIVLFHpvdkngtshpdPAVFASIACMWFMILSSVFSVFFFGIKCYFRITealSRTCNVSSVTKGLQQQLFQA 257
Cdd:pfam10317 163 TDYTVTGFSDLQS-----------FPALINTLIMTIPVFPIPIIILILRRKILKLLN---SNSVNMSPTTKAQHRQLIKG 228
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17542118   258 LVVQTFIPLIlMYIPIAILFTFP-MIAVDIGFASSFVAMTIAVYPAIDPLPNMFIIKNYRKAV 319
Cdd:pfam10317 229 LTIQALLPLF-SYIPGVTLYLLSqLTGTEFLILEYFIFVLPALPPLLDPLITIYFVTPYRRAI 290
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
10-323 1.05e-07

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 52.55  E-value: 1.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542118    10 FLKIVQYTSAFMSVSLNCILIFLILAHSPKKLGMYKYLMIYISSFEALYSL-WDVTTEPMVHSYKAAFVVFRNFKNSDFD 88
Cdd:pfam10318   5 FLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLsLSFLTIPYIFLPALAGYPLGLLSYLGVP 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542118    89 REHSFILIVIYCGCFGFSLAIFgvhFVYRYGAVVKEFRDKWlgGKKIYILFFmPIFYGTWWSVLCYLYFHFDDStdDYMR 168
Cdd:pfam10318  85 TPIQFYIGVTSLALVGVSIILL---FENRYSILFTNKKRIT--WKKTRVLYL-IFNYIIALLFLIPIYLNIPDQ--EAAK 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542118   169 KTIFDGY----DTKIEDTSYIIVLFhpvdkngtshpDPAVFasIACMWFMILSSVFSVFFFGIKCYFRITEALSRTcnVS 244
Cdd:pfam10318 157 LKVLKKLpclpPEFFDNPPVFVLAI-----------DSTYF--LICIVLLILILIIQILFFVFLTIYYLFKSVKSS--LS 221
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17542118   245 SVTKGLQQQLFQALVVQTFIPLILMYIPIAILFTFPMIAVDIGFASSFVAMTIAVYPAIDPLPNMFIIKNYRKAVFAFF 323
Cdd:pfam10318 222 KKTRKLQKKFFIALIIQVSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLF 300
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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