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Conserved domains on  [gi|71998034|ref|NP_500282|]
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Protein NDNF C-terminal domain-containing protein [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NDNF_C super family cl44851
Neuron-derived Neurotrophic Factor C-terminal; This is the C-terminal domain of Neuron-derived ...
 358-532 1.24e-20

Neuron-derived Neurotrophic Factor C-terminal; This is the C-terminal domain of Neuron-derived Neurotrophic Factor (NDNF). NDNF is a glycosylated and disulfide-bonded secreted protein expressed in brain and spinal cord that promotes migration and neurite growth of hippocampal neurons. It also promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization. This domain contains the second fibronectin type III domain (FnIII) present in NDNF and one of the two potential consensus sites for N-linked glycosylation.


The actual alignment was detected with superfamily member pfam19433:

Pssm-ID: 466079  Cd Length: 174  Bit Score: 89.34  E-value: 1.24e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998034   358 RSDAFSGFRRFVVTNIRSGHLRFQIVNDDETPKTIRVWASTDLTTSPYPNLPDDTSVKIVG--RSCSSASIQWIrAHDSH 435
Cdd:pfam19433   4 TSESVEGLRHFQLRGKPKAEYLVRLKSGRKGNSSLKVFATTNPHKQPFPSLPEDTKIKVFDklRTCNSVTVAWL-GTQER 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998034   436 VKYCVYRRREHSNFLEHLvSLADNLCEGGLS--SSVLVGCYTHSPTSSEDDAqsLIEtTIGGLLPASTYRLDLLATpldR 513
Cdd:pfam19433  83 SKYCLYKKEVEEDQVERE-SRKQNRCLGPESrkKSEKVLCKYFHGANLQRAV--TTE-TIEGLEPGTLYLLDVYVI---G 155

                         170
                  ....*....|....*....
gi 71998034   514 PNAQALPFRTVWVRTNRFC 532
Cdd:pfam19433 156 QGGHSVKYQSKVVKTRKRC 174
NDNF pfam10179
Neuron-derived neurotrophic factor, first Fn(III) domain; This domain is found towards the ...
 181-270 1.52e-19

Neuron-derived neurotrophic factor, first Fn(III) domain; This domain is found towards the N-terminal of Neuron-derived neurotrophic factor (NDNF) which contains the first fibronectin type III domain and one of the predicted N-linked glycosylation sites. NDNF is a glycosylated and disulfide-bonded secreted protein expressed in brain and spinal cord that promotes migration and neurite growth. It also promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization.


:

Pssm-ID: 462981  Cd Length: 127  Bit Score: 84.42  E-value: 1.52e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998034   181 LITWKISPQVRNAEPGRYriCTIVSRRDPeFAGMCDHVEE---------------------------------------G 221
Cdd:pfam10179   2 TLKWKPSPSVLDRHPMHY--CLVVNRKHN-YKSLCAAVEAirkeqppgktsksfdpasfeflkerwpqkerklnprvssG 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 71998034   222 VETVKCVPQTNNTVViGSLRRDRTYFVTVFVRDHKRGTSSAYEVQTIQT 270
Cdd:pfam10179  79 DLQIVCVGTKTVQTV-SGLKPDTQYYFDVFVVDQLTNTSSAYLGTFAVT 126
 
Name Accession Description Interval E-value
NDNF_C pfam19433
Neuron-derived Neurotrophic Factor C-terminal; This is the C-terminal domain of Neuron-derived ...
 358-532 1.24e-20

Neuron-derived Neurotrophic Factor C-terminal; This is the C-terminal domain of Neuron-derived Neurotrophic Factor (NDNF). NDNF is a glycosylated and disulfide-bonded secreted protein expressed in brain and spinal cord that promotes migration and neurite growth of hippocampal neurons. It also promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization. This domain contains the second fibronectin type III domain (FnIII) present in NDNF and one of the two potential consensus sites for N-linked glycosylation.


Pssm-ID: 466079  Cd Length: 174  Bit Score: 89.34  E-value: 1.24e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998034   358 RSDAFSGFRRFVVTNIRSGHLRFQIVNDDETPKTIRVWASTDLTTSPYPNLPDDTSVKIVG--RSCSSASIQWIrAHDSH 435
Cdd:pfam19433   4 TSESVEGLRHFQLRGKPKAEYLVRLKSGRKGNSSLKVFATTNPHKQPFPSLPEDTKIKVFDklRTCNSVTVAWL-GTQER 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998034   436 VKYCVYRRREHSNFLEHLvSLADNLCEGGLS--SSVLVGCYTHSPTSSEDDAqsLIEtTIGGLLPASTYRLDLLATpldR 513
Cdd:pfam19433  83 SKYCLYKKEVEEDQVERE-SRKQNRCLGPESrkKSEKVLCKYFHGANLQRAV--TTE-TIEGLEPGTLYLLDVYVI---G 155

                         170
                  ....*....|....*....
gi 71998034   514 PNAQALPFRTVWVRTNRFC 532
Cdd:pfam19433 156 QGGHSVKYQSKVVKTRKRC 174
NDNF pfam10179
Neuron-derived neurotrophic factor, first Fn(III) domain; This domain is found towards the ...
 181-270 1.52e-19

Neuron-derived neurotrophic factor, first Fn(III) domain; This domain is found towards the N-terminal of Neuron-derived neurotrophic factor (NDNF) which contains the first fibronectin type III domain and one of the predicted N-linked glycosylation sites. NDNF is a glycosylated and disulfide-bonded secreted protein expressed in brain and spinal cord that promotes migration and neurite growth. It also promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization.


Pssm-ID: 462981  Cd Length: 127  Bit Score: 84.42  E-value: 1.52e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998034   181 LITWKISPQVRNAEPGRYriCTIVSRRDPeFAGMCDHVEE---------------------------------------G 221
Cdd:pfam10179   2 TLKWKPSPSVLDRHPMHY--CLVVNRKHN-YKSLCAAVEAirkeqppgktsksfdpasfeflkerwpqkerklnprvssG 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 71998034   222 VETVKCVPQTNNTVViGSLRRDRTYFVTVFVRDHKRGTSSAYEVQTIQT 270
Cdd:pfam10179  79 DLQIVCVGTKTVQTV-SGLKPDTQYYFDVFVVDQLTNTSSAYLGTFAVT 126
 
Name Accession Description Interval E-value
NDNF_C pfam19433
Neuron-derived Neurotrophic Factor C-terminal; This is the C-terminal domain of Neuron-derived ...
 358-532 1.24e-20

Neuron-derived Neurotrophic Factor C-terminal; This is the C-terminal domain of Neuron-derived Neurotrophic Factor (NDNF). NDNF is a glycosylated and disulfide-bonded secreted protein expressed in brain and spinal cord that promotes migration and neurite growth of hippocampal neurons. It also promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization. This domain contains the second fibronectin type III domain (FnIII) present in NDNF and one of the two potential consensus sites for N-linked glycosylation.


Pssm-ID: 466079  Cd Length: 174  Bit Score: 89.34  E-value: 1.24e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998034   358 RSDAFSGFRRFVVTNIRSGHLRFQIVNDDETPKTIRVWASTDLTTSPYPNLPDDTSVKIVG--RSCSSASIQWIrAHDSH 435
Cdd:pfam19433   4 TSESVEGLRHFQLRGKPKAEYLVRLKSGRKGNSSLKVFATTNPHKQPFPSLPEDTKIKVFDklRTCNSVTVAWL-GTQER 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998034   436 VKYCVYRRREHSNFLEHLvSLADNLCEGGLS--SSVLVGCYTHSPTSSEDDAqsLIEtTIGGLLPASTYRLDLLATpldR 513
Cdd:pfam19433  83 SKYCLYKKEVEEDQVERE-SRKQNRCLGPESrkKSEKVLCKYFHGANLQRAV--TTE-TIEGLEPGTLYLLDVYVI---G 155

                         170
                  ....*....|....*....
gi 71998034   514 PNAQALPFRTVWVRTNRFC 532
Cdd:pfam19433 156 QGGHSVKYQSKVVKTRKRC 174
NDNF pfam10179
Neuron-derived neurotrophic factor, first Fn(III) domain; This domain is found towards the ...
 181-270 1.52e-19

Neuron-derived neurotrophic factor, first Fn(III) domain; This domain is found towards the N-terminal of Neuron-derived neurotrophic factor (NDNF) which contains the first fibronectin type III domain and one of the predicted N-linked glycosylation sites. NDNF is a glycosylated and disulfide-bonded secreted protein expressed in brain and spinal cord that promotes migration and neurite growth. It also promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization.


Pssm-ID: 462981  Cd Length: 127  Bit Score: 84.42  E-value: 1.52e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998034   181 LITWKISPQVRNAEPGRYriCTIVSRRDPeFAGMCDHVEE---------------------------------------G 221
Cdd:pfam10179   2 TLKWKPSPSVLDRHPMHY--CLVVNRKHN-YKSLCAAVEAirkeqppgktsksfdpasfeflkerwpqkerklnprvssG 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 71998034   222 VETVKCVPQTNNTVViGSLRRDRTYFVTVFVRDHKRGTSSAYEVQTIQT 270
Cdd:pfam10179  79 DLQIVCVGTKTVQTV-SGLKPDTQYYFDVFVVDQLTNTSSAYLGTFAVT 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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