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Conserved domains on  [gi|25148371|ref|NP_500065|]
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UDENN domain-containing protein [Caenorhabditis elegans]

Protein Classification

DENND11 family protein( domain architecture ID 1750197)

DENND11 family protein similar to Homo sapiens DENN domain-containing protein 10, a guanine nucleotide exchange factor (GEF) regulating homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion, possibly through activating Rab proteins such as RAB27A and RAB27B

Gene Ontology:  GO:0031267|GO:0015031|GO:0005085

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SPA super family cl40631
Stabilization of polarity axis; Swiss:Q99222 has been shown to interact with the outer plaque ...
 238-315 2.90e-03

Stabilization of polarity axis; Swiss:Q99222 has been shown to interact with the outer plaque of the spindle pole body. In Aspergillus nidulans the protein member is necessary for stabilization of the polarity axes during septation. and in S. cerevisiae it functions as a polarization-specific docking factor.


The actual alignment was detected with superfamily member pfam08616:

Pssm-ID: 454797  Cd Length: 113  Bit Score: 37.65  E-value: 2.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148371   238 GEPLLIVAPTPSITS----ALV-QSIVGLLSPLR-IVNDFRPYFTIHD-SEFREYssksrspPRVILGVTNPFFIKALDH 310
Cdd:pfam08616  25 SKRIIFLSYQRSAGEvsefVLAlCNLISGGFVLRgFTNNSFPYVDLSKlDALRKV-------PGYIAGVTNPIFENQDQW 97


                  ....*
gi 25148371   311 WPHIL 315
Cdd:pfam08616  98 WDVLC 102
 
Name Accession Description Interval E-value
SPA pfam08616
Stabilization of polarity axis; Swiss:Q99222 has been shown to interact with the outer plaque ...
 238-315 2.90e-03

Stabilization of polarity axis; Swiss:Q99222 has been shown to interact with the outer plaque of the spindle pole body. In Aspergillus nidulans the protein member is necessary for stabilization of the polarity axes during septation. and in S. cerevisiae it functions as a polarization-specific docking factor.


Pssm-ID: 400783  Cd Length: 113  Bit Score: 37.65  E-value: 2.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148371   238 GEPLLIVAPTPSITS----ALV-QSIVGLLSPLR-IVNDFRPYFTIHD-SEFREYssksrspPRVILGVTNPFFIKALDH 310
Cdd:pfam08616  25 SKRIIFLSYQRSAGEvsefVLAlCNLISGGFVLRgFTNNSFPYVDLSKlDALRKV-------PGYIAGVTNPIFENQDQW 97


                  ....*
gi 25148371   311 WPHIL 315
Cdd:pfam08616  98 WDVLC 102
 
Name Accession Description Interval E-value
SPA pfam08616
Stabilization of polarity axis; Swiss:Q99222 has been shown to interact with the outer plaque ...
 238-315 2.90e-03

Stabilization of polarity axis; Swiss:Q99222 has been shown to interact with the outer plaque of the spindle pole body. In Aspergillus nidulans the protein member is necessary for stabilization of the polarity axes during septation. and in S. cerevisiae it functions as a polarization-specific docking factor.


Pssm-ID: 400783  Cd Length: 113  Bit Score: 37.65  E-value: 2.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148371   238 GEPLLIVAPTPSITS----ALV-QSIVGLLSPLR-IVNDFRPYFTIHD-SEFREYssksrspPRVILGVTNPFFIKALDH 310
Cdd:pfam08616  25 SKRIIFLSYQRSAGEvsefVLAlCNLISGGFVLRgFTNNSFPYVDLSKlDALRKV-------PGYIAGVTNPIFENQDQW 97


                  ....*
gi 25148371   311 WPHIL 315
Cdd:pfam08616  98 WDVLC 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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