|
Name |
Accession |
Description |
Interval |
E-value |
| Ssl1 |
pfam04056 |
Ssl1-like; Ssl1-like proteins are 40kDa subunits of the Transcription factor II H complex. |
68-245 |
3.84e-106 |
|
Ssl1-like; Ssl1-like proteins are 40kDa subunits of the Transcription factor II H complex.
Pssm-ID: 461149 Cd Length: 178 Bit Score: 309.36 E-value: 3.84e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555086 68 VIDCSRFMTSKAMPPSRFVVVMKALQTFLDRFFEQNPIAQIGLITCKDRKADRLTMMTGNIRVLKESLNTLTEAFCGGDF 147
Cdd:pfam04056 1 VLDCSRSMEEKDLRPSRFACTIKYLETFVEEFFDQNPISQIGLITCKDGRAHRLTDLTGNPRVHIKALKSLREAECGGDP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555086 148 SLQNALQLACANLKGMPGHVSREVVLVISALSTIDPGNIYSTIETMKRMNIRCSAIGLSAEMFVCKEMAKATKGEYSVAL 227
Cdd:pfam04056 81 SLQNALELARASLKHVPSHGSREVLIIFGSLSTCDPGDIYSTIDTLKKEKIRCSVIGLSAEVFICKELCKATNGTYSVAL 160
|
170
....*....|....*...
gi 17555086 228 DPDHLQLLFSKHTLPPSS 245
Cdd:pfam04056 161 DETHLKELLLEHVLPPPA 178
|
|
| vWA_transcription_factor_IIH_type |
cd01453 |
Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five ... |
60-244 |
3.60e-99 |
|
Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five general transcription factors that binds RNA polymerase II holoenzyme. Orthologues of these genes are found in all completed eukaryotic genomes and all these proteins contain a VWA domain. The p44 subunit of TFIIH functions as a DNA helicase in RNA polymerase II transcription initiation and DNA repair, and its transcriptional activity is dependent on its C-terminal Zn-binding domains. The function of the vWA domain is unclear, but may be involved in complex assembly. The MIDAS motif is not conserved in this sub-group.
Pssm-ID: 238730 Cd Length: 183 Bit Score: 291.93 E-value: 3.60e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555086 60 GIMRHVMIVIDCSRFMTSKAMPPSRFVVVMKALQTFLDRFFEQNPIAQIGLITCKDRKADRLTMMTGNIRvlkESLNTLT 139
Cdd:cd01453 1 GIMRHLIIVIDCSRSMEEQDLKPSRLAVVLKLLELFIEEFFDQNPISQLGIISIKNGRAEKLTDLTGNPR---KHIQALK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555086 140 EA-FCGGDFSLQNALQLACANLKGMPGHVSREVVLVISALSTIDPGNIYSTIETMKRMNIRCSAIGLSAEMFVCKEMAKA 218
Cdd:cd01453 78 TArECSGEPSLQNGLEMALESLKHMPSHGSREVLIIFSSLSTCDPGNIYETIDKLKKENIRVSVIGLSAEMHICKEICKA 157
|
170 180
....*....|....*....|....*.
gi 17555086 219 TKGEYSVALDPDHLQLLFSKHTLPPS 244
Cdd:cd01453 158 TNGTYKVILDETHLKELLLEHVTPPP 183
|
|
| SSL1 |
COG5151 |
RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit ... |
3-375 |
1.08e-86 |
|
RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1 [Transcription / DNA replication, recombination, and repair];
Pssm-ID: 227480 [Multi-domain] Cd Length: 421 Bit Score: 268.40 E-value: 1.08e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555086 3 DDEQKGYTWEAGYAEGLninDVLVEDEGGSIEKSIAKYVADSKRKaRLTKRPERIRLGIMRHVMIVIDCSRFMTSKAMPP 82
Cdd:COG5151 32 DDMNKGYSWEQEYKRSW---DDVNDDKEGSLVGVVAEFNLETKAP-YSNNRTTPLQRGIIRHLHLILDVSEAMDESDFLP 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555086 83 SRFVVVMKALQTFLDRFFEQNPIAQIGLITCKDRKADRLTMMTGNIRVLKESLNTLTEafCGGDFSLQNALQLACANLKG 162
Cdd:COG5151 108 TRRANVIKYAEGFVPEFFSQNPISQLSIISIRDGCAKYTSSMDGNPQAHIGQLKSKRD--CSGNFSLQNALEMARIELMK 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555086 163 MPGHVSREVVLVISALSTIDPGNIYSTIETMKRMNIRCSAIGLSAEMFVCKEMAKAT----KGEYSVALDPDHLQLLFSK 238
Cdd:COG5151 186 NTMHGTREVLIIFGSTSTRDPGDIAETIDKLVAYNIRVHFIGLCAEVAICKEICKATnsstEGRYYVPVDEGHLSELMRE 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555086 239 HTLPPSSAKS-SECNAIHVGFPHHELITTRSFCVCHPDtkpISSRGFICTQCGARHCSIPAECPVCKLTLVAAPQLARAF 317
Cdd:COG5151 266 LSHPTDFNGTkTDLSLVKMGFPSPMMEQLPSVCACHSE---VKGGGYECPVCKTKVCSLPISCPICSLQLILSTHLARSY 342
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17555086 318 RHLQPLSAFEQIEVTRGF----CYACETR------------LSGEGFRCGSCQLVFCLDCDTLLHESLHVCPGC 375
Cdd:COG5151 343 HHLYPLKPFVEKPEGTNPksthCFVCQGPfpkppvspfdesTSSGRYQCELCKSTFCSDCDVFIHETLHFCIGC 416
|
|
| ssl1 |
TIGR00622 |
transcription factor ssl1; All proteins in this family for which functions are known are ... |
283-375 |
8.95e-26 |
|
transcription factor ssl1; All proteins in this family for which functions are known are components of the TFIIH complex which is involved in the initiaiton of transcription and nucleotide excision repair.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 129709 Cd Length: 112 Bit Score: 100.01 E-value: 8.95e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555086 283 GFICTQCGARHCSIPAECPVCKLTLVAAPQLARAFRHLQPLSAFEQIEVTRG----FCYACETR------------LSGE 346
Cdd:TIGR00622 1 GYFCPQCRAKVCELPVECPICGLTLILSTHLARSYHHLFPLKAFQEIPLEEYngsrFCFGCQGPfpkppvspfdelKDSH 80
|
90 100
....*....|....*....|....*....
gi 17555086 347 GFRCGSCQLVFCLDCDTLLHESLHVCPGC 375
Cdd:TIGR00622 81 RYVCAVCKNVFCVDCDVFVHESLHCCPGC 109
|
|
| VWA |
smart00327 |
von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins ... |
64-239 |
1.49e-17 |
|
von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins mediate adhesion via metal ion-dependent adhesion sites (MIDAS). Intracellular VWA domains and homologues in prokaryotes have recently been identified. The proposed VWA domains in integrin beta subunits have recently been substantiated using sequence-based methods.
Pssm-ID: 214621 [Multi-domain] Cd Length: 175 Bit Score: 79.42 E-value: 1.49e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555086 64 HVMIVIDCSRFMTskampPSRFVVVMKALQTFLDRFFEQNPIAQIGLITCKDRKADRLTM-MTGNIRVLKESLNTLTEaF 142
Cdd:smart00327 1 DVVFLLDGSGSMG-----GNRFELAKEFVLKLVEQLDIGPDGDRVGLVTFSDDARVLFPLnDSRSKDALLEALASLSY-K 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555086 143 CGGDFSLQNALQLACANLKGMPGHVSRE---VVLVISAL-STIDPGNIYSTIETMKRMNIRCSAIGLS--AEMFVCKEMA 216
Cdd:smart00327 75 LGGGTNLGAALQYALENLFSKSAGSRRGapkVVILITDGeSNDGPKDLLKAAKELKRSGVKVFVVGVGndVDEEELKKLA 154
|
170 180
....*....|....*....|...
gi 17555086 217 KATKGEYSValDPDHLQLLFSKH 239
Cdd:smart00327 155 SAPGGVYVF--LPELLDLLIDLL 175
|
|
| ChlD |
COG1240 |
vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and ... |
48-238 |
1.73e-14 |
|
vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and metabolism];
Pssm-ID: 440853 [Multi-domain] Cd Length: 262 Bit Score: 72.66 E-value: 1.73e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555086 48 ARLTKRPERIRLGIMRHVMIVIDCSRFMTSKamppSRFVVVMKALQTFLDRFFEQNpiaQIGLITCKDRkADRLTMMTGN 127
Cdd:COG1240 78 ALALAPLALARPQRGRDVVLVVDASGSMAAE----NRLEAAKGALLDFLDDYRPRD---RVGLVAFGGE-AEVLLPLTRD 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555086 128 IRVLKESLNTLTeafCGGDFSLQNALQLACANLKGMPGHVSReVVLVIS-ALSTIDPGNIYSTIETMKRMNIRCSAIGLS 206
Cdd:COG1240 150 REALKRALDELP---PGGGTPLGDALALALELLKRADPARRK-VIVLLTdGRDNAGRIDPLEAAELAAAAGIRIYTIGVG 225
|
170 180 190
....*....|....*....|....*....|....*
gi 17555086 207 AEMF---VCKEMAKATKGEYSVALDPDHLQLLFSK 238
Cdd:COG1240 226 TEAVdegLLREIAEATGGRYFRADDLSELAAIYRE 260
|
|
| C1_4 |
smart01047 |
TFIIH C1-like domain; The carboxyl-terminal region of TFIIH is essential for transcription ... |
336-376 |
3.21e-13 |
|
TFIIH C1-like domain; The carboxyl-terminal region of TFIIH is essential for transcription activity. This regions binds three zinc atoms through two independent domain. The first contains a C4 zinc finger motif, whereas the second is characterised by a CX(2)CX(2-4)FCADCD motif. The solution structure of the second C-terminal domain revealed homology with the regulatory domain of protein kinase C.
Pssm-ID: 214993 Cd Length: 49 Bit Score: 63.53 E-value: 3.21e-13
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 17555086 336 CYACETRLSGEG--------FRCGSCQLVFCLDCDTLLHESLHVCPGCN 376
Cdd:smart01047 1 CFGCQSPFPNSKdksvtssrYRCTKCKQVFCIDCDVFIHETLHNCPGCE 49
|
|
| C1_4 |
pfam07975 |
TFIIH C1-like domain; The carboxyl-terminal region of TFIIH is essential for transcription ... |
335-376 |
5.57e-10 |
|
TFIIH C1-like domain; The carboxyl-terminal region of TFIIH is essential for transcription activity. This regions binds three zinc atoms through two independent domain. The first contains a C4 zinc finger motif, whereas the second is characterized by a CX(2)CX(2-4)FCADCD motif. The solution structure of the second C-terminal domain revealed homology with the regulatory domain of protein kinase C (pfam00130).
Pssm-ID: 336887 Cd Length: 55 Bit Score: 54.41 E-value: 5.57e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 17555086 335 FCYACETRLSGEG------------FRCGSCQLVFCLDCDTLLHESLHVCPGCN 376
Cdd:pfam07975 1 NCYGCQKKFPKGInkktdelltssrYRCPKCKQDFCIDCDVFIHESLHNCPGCE 54
|
|
| tfb4 |
TIGR00627 |
transcription factor tfb4; All proteins in this family are part of the TFIIH complex which is ... |
168-304 |
1.08e-04 |
|
transcription factor tfb4; All proteins in this family are part of the TFIIH complex which is involved in the initiation of transcription and nucleotide excision repair.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273181 Cd Length: 279 Bit Score: 43.67 E-value: 1.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555086 168 SREVVLVISALSTIDPGNIYSTIETMKRMNIRCSA--IGLSAEMFVCKEMAKATKGEYSVALDPDHLQLLFSKHTLPPSS 245
Cdd:TIGR00627 147 SRILVISITPDMALQYIPLMNCIFSAQKQNIPIDVvsIGGDFTSGFLQQAADITGGSYLHVKKPQGLLQYLMTNMLPDPT 226
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 17555086 246 AKSsecnaiHVGFPHHELITTRSFCVCHpdtKPISSRGFICTQCGARHCSIPAECPVCK 304
Cdd:TIGR00627 227 LRA------VLSKPNHNSVDYRASCFCH---HQLVSIGFVCSVCLSVLCQYTPICKTCK 276
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Ssl1 |
pfam04056 |
Ssl1-like; Ssl1-like proteins are 40kDa subunits of the Transcription factor II H complex. |
68-245 |
3.84e-106 |
|
Ssl1-like; Ssl1-like proteins are 40kDa subunits of the Transcription factor II H complex.
Pssm-ID: 461149 Cd Length: 178 Bit Score: 309.36 E-value: 3.84e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555086 68 VIDCSRFMTSKAMPPSRFVVVMKALQTFLDRFFEQNPIAQIGLITCKDRKADRLTMMTGNIRVLKESLNTLTEAFCGGDF 147
Cdd:pfam04056 1 VLDCSRSMEEKDLRPSRFACTIKYLETFVEEFFDQNPISQIGLITCKDGRAHRLTDLTGNPRVHIKALKSLREAECGGDP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555086 148 SLQNALQLACANLKGMPGHVSREVVLVISALSTIDPGNIYSTIETMKRMNIRCSAIGLSAEMFVCKEMAKATKGEYSVAL 227
Cdd:pfam04056 81 SLQNALELARASLKHVPSHGSREVLIIFGSLSTCDPGDIYSTIDTLKKEKIRCSVIGLSAEVFICKELCKATNGTYSVAL 160
|
170
....*....|....*...
gi 17555086 228 DPDHLQLLFSKHTLPPSS 245
Cdd:pfam04056 161 DETHLKELLLEHVLPPPA 178
|
|
| vWA_transcription_factor_IIH_type |
cd01453 |
Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five ... |
60-244 |
3.60e-99 |
|
Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five general transcription factors that binds RNA polymerase II holoenzyme. Orthologues of these genes are found in all completed eukaryotic genomes and all these proteins contain a VWA domain. The p44 subunit of TFIIH functions as a DNA helicase in RNA polymerase II transcription initiation and DNA repair, and its transcriptional activity is dependent on its C-terminal Zn-binding domains. The function of the vWA domain is unclear, but may be involved in complex assembly. The MIDAS motif is not conserved in this sub-group.
Pssm-ID: 238730 Cd Length: 183 Bit Score: 291.93 E-value: 3.60e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555086 60 GIMRHVMIVIDCSRFMTSKAMPPSRFVVVMKALQTFLDRFFEQNPIAQIGLITCKDRKADRLTMMTGNIRvlkESLNTLT 139
Cdd:cd01453 1 GIMRHLIIVIDCSRSMEEQDLKPSRLAVVLKLLELFIEEFFDQNPISQLGIISIKNGRAEKLTDLTGNPR---KHIQALK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555086 140 EA-FCGGDFSLQNALQLACANLKGMPGHVSREVVLVISALSTIDPGNIYSTIETMKRMNIRCSAIGLSAEMFVCKEMAKA 218
Cdd:cd01453 78 TArECSGEPSLQNGLEMALESLKHMPSHGSREVLIIFSSLSTCDPGNIYETIDKLKKENIRVSVIGLSAEMHICKEICKA 157
|
170 180
....*....|....*....|....*.
gi 17555086 219 TKGEYSVALDPDHLQLLFSKHTLPPS 244
Cdd:cd01453 158 TNGTYKVILDETHLKELLLEHVTPPP 183
|
|
| SSL1 |
COG5151 |
RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit ... |
3-375 |
1.08e-86 |
|
RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1 [Transcription / DNA replication, recombination, and repair];
Pssm-ID: 227480 [Multi-domain] Cd Length: 421 Bit Score: 268.40 E-value: 1.08e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555086 3 DDEQKGYTWEAGYAEGLninDVLVEDEGGSIEKSIAKYVADSKRKaRLTKRPERIRLGIMRHVMIVIDCSRFMTSKAMPP 82
Cdd:COG5151 32 DDMNKGYSWEQEYKRSW---DDVNDDKEGSLVGVVAEFNLETKAP-YSNNRTTPLQRGIIRHLHLILDVSEAMDESDFLP 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555086 83 SRFVVVMKALQTFLDRFFEQNPIAQIGLITCKDRKADRLTMMTGNIRVLKESLNTLTEafCGGDFSLQNALQLACANLKG 162
Cdd:COG5151 108 TRRANVIKYAEGFVPEFFSQNPISQLSIISIRDGCAKYTSSMDGNPQAHIGQLKSKRD--CSGNFSLQNALEMARIELMK 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555086 163 MPGHVSREVVLVISALSTIDPGNIYSTIETMKRMNIRCSAIGLSAEMFVCKEMAKAT----KGEYSVALDPDHLQLLFSK 238
Cdd:COG5151 186 NTMHGTREVLIIFGSTSTRDPGDIAETIDKLVAYNIRVHFIGLCAEVAICKEICKATnsstEGRYYVPVDEGHLSELMRE 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555086 239 HTLPPSSAKS-SECNAIHVGFPHHELITTRSFCVCHPDtkpISSRGFICTQCGARHCSIPAECPVCKLTLVAAPQLARAF 317
Cdd:COG5151 266 LSHPTDFNGTkTDLSLVKMGFPSPMMEQLPSVCACHSE---VKGGGYECPVCKTKVCSLPISCPICSLQLILSTHLARSY 342
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17555086 318 RHLQPLSAFEQIEVTRGF----CYACETR------------LSGEGFRCGSCQLVFCLDCDTLLHESLHVCPGC 375
Cdd:COG5151 343 HHLYPLKPFVEKPEGTNPksthCFVCQGPfpkppvspfdesTSSGRYQCELCKSTFCSDCDVFIHETLHFCIGC 416
|
|
| ssl1 |
TIGR00622 |
transcription factor ssl1; All proteins in this family for which functions are known are ... |
283-375 |
8.95e-26 |
|
transcription factor ssl1; All proteins in this family for which functions are known are components of the TFIIH complex which is involved in the initiaiton of transcription and nucleotide excision repair.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 129709 Cd Length: 112 Bit Score: 100.01 E-value: 8.95e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555086 283 GFICTQCGARHCSIPAECPVCKLTLVAAPQLARAFRHLQPLSAFEQIEVTRG----FCYACETR------------LSGE 346
Cdd:TIGR00622 1 GYFCPQCRAKVCELPVECPICGLTLILSTHLARSYHHLFPLKAFQEIPLEEYngsrFCFGCQGPfpkppvspfdelKDSH 80
|
90 100
....*....|....*....|....*....
gi 17555086 347 GFRCGSCQLVFCLDCDTLLHESLHVCPGC 375
Cdd:TIGR00622 81 RYVCAVCKNVFCVDCDVFVHESLHCCPGC 109
|
|
| VWA |
smart00327 |
von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins ... |
64-239 |
1.49e-17 |
|
von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins mediate adhesion via metal ion-dependent adhesion sites (MIDAS). Intracellular VWA domains and homologues in prokaryotes have recently been identified. The proposed VWA domains in integrin beta subunits have recently been substantiated using sequence-based methods.
Pssm-ID: 214621 [Multi-domain] Cd Length: 175 Bit Score: 79.42 E-value: 1.49e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555086 64 HVMIVIDCSRFMTskampPSRFVVVMKALQTFLDRFFEQNPIAQIGLITCKDRKADRLTM-MTGNIRVLKESLNTLTEaF 142
Cdd:smart00327 1 DVVFLLDGSGSMG-----GNRFELAKEFVLKLVEQLDIGPDGDRVGLVTFSDDARVLFPLnDSRSKDALLEALASLSY-K 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555086 143 CGGDFSLQNALQLACANLKGMPGHVSRE---VVLVISAL-STIDPGNIYSTIETMKRMNIRCSAIGLS--AEMFVCKEMA 216
Cdd:smart00327 75 LGGGTNLGAALQYALENLFSKSAGSRRGapkVVILITDGeSNDGPKDLLKAAKELKRSGVKVFVVGVGndVDEEELKKLA 154
|
170 180
....*....|....*....|...
gi 17555086 217 KATKGEYSValDPDHLQLLFSKH 239
Cdd:smart00327 155 SAPGGVYVF--LPELLDLLIDLL 175
|
|
| ChlD |
COG1240 |
vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and ... |
48-238 |
1.73e-14 |
|
vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and metabolism];
Pssm-ID: 440853 [Multi-domain] Cd Length: 262 Bit Score: 72.66 E-value: 1.73e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555086 48 ARLTKRPERIRLGIMRHVMIVIDCSRFMTSKamppSRFVVVMKALQTFLDRFFEQNpiaQIGLITCKDRkADRLTMMTGN 127
Cdd:COG1240 78 ALALAPLALARPQRGRDVVLVVDASGSMAAE----NRLEAAKGALLDFLDDYRPRD---RVGLVAFGGE-AEVLLPLTRD 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555086 128 IRVLKESLNTLTeafCGGDFSLQNALQLACANLKGMPGHVSReVVLVIS-ALSTIDPGNIYSTIETMKRMNIRCSAIGLS 206
Cdd:COG1240 150 REALKRALDELP---PGGGTPLGDALALALELLKRADPARRK-VIVLLTdGRDNAGRIDPLEAAELAAAAGIRIYTIGVG 225
|
170 180 190
....*....|....*....|....*....|....*
gi 17555086 207 AEMF---VCKEMAKATKGEYSVALDPDHLQLLFSK 238
Cdd:COG1240 226 TEAVdegLLREIAEATGGRYFRADDLSELAAIYRE 260
|
|
| VWA_2 |
pfam13519 |
von Willebrand factor type A domain; |
65-174 |
3.14e-14 |
|
von Willebrand factor type A domain;
Pssm-ID: 463909 [Multi-domain] Cd Length: 103 Bit Score: 68.09 E-value: 3.14e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555086 65 VMIVIDCSRFMTSKAMPPSRFVvvmkALQTFLDRFFEQNPIAQIGLITCKDRkADRLTMMTGNIRVLKESLNTLTEafCG 144
Cdd:pfam13519 1 LVFVLDTSGSMRNGDYGPTRLE----AAKDAVLALLKSLPGDRVGLVTFGDG-PEVLIPLTKDRAKILRALRRLEP--KG 73
|
90 100 110
....*....|....*....|....*....|
gi 17555086 145 GDFSLQNALQLACANLKGMPGHVSREVVLV 174
Cdd:pfam13519 74 GGTNLAAALQLARAALKHRRKNQPRRIVLI 103
|
|
| C1_4 |
smart01047 |
TFIIH C1-like domain; The carboxyl-terminal region of TFIIH is essential for transcription ... |
336-376 |
3.21e-13 |
|
TFIIH C1-like domain; The carboxyl-terminal region of TFIIH is essential for transcription activity. This regions binds three zinc atoms through two independent domain. The first contains a C4 zinc finger motif, whereas the second is characterised by a CX(2)CX(2-4)FCADCD motif. The solution structure of the second C-terminal domain revealed homology with the regulatory domain of protein kinase C.
Pssm-ID: 214993 Cd Length: 49 Bit Score: 63.53 E-value: 3.21e-13
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 17555086 336 CYACETRLSGEG--------FRCGSCQLVFCLDCDTLLHESLHVCPGCN 376
Cdd:smart01047 1 CFGCQSPFPNSKdksvtssrYRCTKCKQVFCIDCDVFIHETLHNCPGCE 49
|
|
| vWFA |
cd00198 |
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ... |
63-225 |
3.47e-13 |
|
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.
Pssm-ID: 238119 [Multi-domain] Cd Length: 161 Bit Score: 66.82 E-value: 3.47e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555086 63 RHVMIVIDCSRfmtskAMPPSRFVVVMKALQTFLDRFFEQNPIAQIGLITCKDRKADRLTMMTGNIRVLKESLNTLTEAF 142
Cdd:cd00198 1 ADIVFLLDVSG-----SMGGEKLDKAKEALKALVSSLSASPPGDRVGLVTFGSNARVVLPLTTDTDKADLLEAIDALKKG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555086 143 CGGDFSLQNALQLACANLKGMPGHVSREVVLVIS-ALSTIDPGNIYSTIETMKRMNIRCSAIGL--SAEMFVCKEMAKAT 219
Cdd:cd00198 76 LGGGTNIGAALRLALELLKSAKRPNARRVIILLTdGEPNDGPELLAEAARELRKLGITVYTIGIgdDANEDELKEIADKT 155
|
....*.
gi 17555086 220 KGEYSV 225
Cdd:cd00198 156 TGGAVF 161
|
|
| C1_4 |
pfam07975 |
TFIIH C1-like domain; The carboxyl-terminal region of TFIIH is essential for transcription ... |
335-376 |
5.57e-10 |
|
TFIIH C1-like domain; The carboxyl-terminal region of TFIIH is essential for transcription activity. This regions binds three zinc atoms through two independent domain. The first contains a C4 zinc finger motif, whereas the second is characterized by a CX(2)CX(2-4)FCADCD motif. The solution structure of the second C-terminal domain revealed homology with the regulatory domain of protein kinase C (pfam00130).
Pssm-ID: 336887 Cd Length: 55 Bit Score: 54.41 E-value: 5.57e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 17555086 335 FCYACETRLSGEG------------FRCGSCQLVFCLDCDTLLHESLHVCPGCN 376
Cdd:pfam07975 1 NCYGCQKKFPKGInkktdelltssrYRCPKCKQDFCIDCDVFIHESLHNCPGCE 54
|
|
| tfb4 |
TIGR00627 |
transcription factor tfb4; All proteins in this family are part of the TFIIH complex which is ... |
168-304 |
1.08e-04 |
|
transcription factor tfb4; All proteins in this family are part of the TFIIH complex which is involved in the initiation of transcription and nucleotide excision repair.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273181 Cd Length: 279 Bit Score: 43.67 E-value: 1.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555086 168 SREVVLVISALSTIDPGNIYSTIETMKRMNIRCSA--IGLSAEMFVCKEMAKATKGEYSVALDPDHLQLLFSKHTLPPSS 245
Cdd:TIGR00627 147 SRILVISITPDMALQYIPLMNCIFSAQKQNIPIDVvsIGGDFTSGFLQQAADITGGSYLHVKKPQGLLQYLMTNMLPDPT 226
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 17555086 246 AKSsecnaiHVGFPHHELITTRSFCVCHpdtKPISSRGFICTQCGARHCSIPAECPVCK 304
Cdd:TIGR00627 227 LRA------VLSKPNHNSVDYRASCFCH---HQLVSIGFVCSVCLSVLCQYTPICKTCK 276
|
|
| TFB4 |
COG5242 |
RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit ... |
166-304 |
4.98e-04 |
|
RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB4 [Transcription / DNA replication, recombination, and repair];
Pssm-ID: 227567 Cd Length: 296 Bit Score: 41.57 E-value: 4.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555086 166 HVSREVVL----VISALSTIDPGNIYstIETMK------RMNIRCSAIGLSAEMFVCKEMAKATKGEYSVALDPDHL--- 232
Cdd:COG5242 144 HRDEETSLksriLIFTLSGRDRKDQY--IPYMNcifaaqKFGIPISVFSIFGNSKFLLQCCDATGGDYLTVEDTEGLlqy 221
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17555086 233 --QLLFSKHTLPPssakssecnaiHVGFPHHELITTRSFCVCHpdtKPISSRGFICTQCGARHCSIPAECPVCK 304
Cdd:COG5242 222 llSLLFTDGELRP-----------LGVKPNHGSVDFRATCYCH---NRVVLLGFVCSVCLSVFCRPVPVCKKCK 281
|
|
| YeaD2 |
COG1721 |
Uncharacterized conserved protein, DUF58 family, contains vWF domain [Function unknown]; |
63-186 |
2.03e-03 |
|
Uncharacterized conserved protein, DUF58 family, contains vWF domain [Function unknown];
Pssm-ID: 441327 [Multi-domain] Cd Length: 287 Bit Score: 39.42 E-value: 2.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555086 63 RHVMIVIDCSRFMTSKAMPPSRFVVVMKALQTFLDRFFEQNpiAQIGLITCKDRKADRLTMMTGNiRVLKESLNTLTEAF 142
Cdd:COG1721 148 LTVVLLLDTSASMRFGSGGPSKLDLAVEAAASLAYLALRQG--DRVGLLTFGDRVRRYLPPRRGR-RHLLRLLEALARLE 224
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 17555086 143 CGGDFSLQNALQLACANLKgmpghvSREVVLVISALSTIDPGNI 186
Cdd:COG1721 225 PAGETDLAAALRRLARRLP------RRSLVVLISDFLDPEELGI 262
|
|
| |
