|
Name |
Accession |
Description |
Interval |
E-value |
| Peptidase_C19G |
cd02663 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
58-392 |
1.82e-170 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239128 [Multi-domain] Cd Length: 300 Bit Score: 478.73 E-value: 1.82e-170
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 58 DNLVTCLADLFHSIASQKRRVGTIAPKRFITKLKKENELFDNYMQQDAHEFFNYLINTISETLIQEKIAEREKASrhgtl 137
Cdd:cd02663 21 ENLLTCLKDLFESISEQKKRTGVISPKKFITRLKRENELFDNYMHQDAHEFLNFLLNEIAEILDAERKAEKANRK----- 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 138 kkgnvtvnlapataglprsdekgtsernggitveGNEFLNKSDTTTWIHEIFQGILTNETRCLSCETVSSKDEDFLDLSI 217
Cdd:cd02663 96 ----------------------------------LNNNNNAEPQPTWVHEIFQGILTNETRCLTCETVSSRDETFLDLSI 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 218 DVEQNTSISHCLRVFSETETLCGDQKYFCETCSSKQEAQKRMRIKKPPQLLALHLKRFKFVEPLNRHTKLSYRVVFPLEL 297
Cdd:cd02663 142 DVEQNTSITSCLRQFSATETLCGRNKFYCDECCSLQEAEKRMKIKKLPKILALHLKRFKYDEQLNRYIKLFYRVVFPLEL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 298 RLFNVSDDAEYGDRMYDLVATVVHCGATPNRGHYITLVKSNSFWLVFDDDIVEKLEVSSMEEFSGmstdaniqmppgnqs 377
Cdd:cd02663 222 RLFNTTDDAENPDRLYELVAVVVHIGGGPNHGHYVSIVKSHGGWLLFDDETVEKIDENAVEEFFG--------------- 286
|
330
....*....|....*
gi 193210244 378 aPQKNSESAYILFYQ 392
Cdd:cd02663 287 -DSPNQATAYVLFYQ 300
|
|
| UCH |
pfam00443 |
Ubiquitin carboxyl-terminal hydrolase; |
28-391 |
9.83e-66 |
|
Ubiquitin carboxyl-terminal hydrolase;
Pssm-ID: 425685 [Multi-domain] Cd Length: 310 Bit Score: 212.30 E-value: 9.83e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 28 GLVN------------ALFFCRPFREKVLNYKQTLKKSGASKD-NLVTCLADLFHSIASQKRRVGtIAPKRFITKLKKEN 94
Cdd:pfam00443 2 GLVNlgntcymnsvlqSLFSIPPFRDYLLRISPLSEDSRYNKDiNLLCALRDLFKALQKNSKSSS-VSPKMFKKSLGKLN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 95 ELFDNYMQQDAHEFFNYLINTISETLIQEKIAEREkasrhgtlkkgnvtvnlapataglprsdekgtsernggitvegne 174
Cdd:pfam00443 81 PDFSGYKQQDAQEFLLFLLDGLHEDLNGNHSTENE--------------------------------------------- 115
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 175 flnksdttTWIHEIFQGILTNETRCLSCETVSSKDEDFLDLSIDVEQNTSISH------CLRVFSETETLCGDQKYFCET 248
Cdd:pfam00443 116 --------SLITDLFRGQLKSRLKCLSCGEVSETFEPFSDLSLPIPGDSAELKtaslqiCFLQFSKLEELDDEEKYYCDK 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 249 CSSKQEAQKRMRIKKPPQLLALHLKRFKFVEPLNrhTKLSYRVVFPLELRLFNVSDDAEYGD----RMYDLVATVVHCGa 324
Cdd:pfam00443 188 CGCKQDAIKQLKISRLPPVLIIHLKRFSYNRSTW--EKLNTEVEFPLELDLSRYLAEELKPKtnnlQDYRLVAVVVHSG- 264
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 193210244 325 TPNRGHYITLVKS--NSFWLVFDDDIVEKLEVSSMEEfsgmstdaniqmppgnqsapqknSESAYILFY 391
Cdd:pfam00443 265 SLSSGHYIAYIKAyeNNRWYKFDDEKVTEVDEETAVL-----------------------SSSAYILFY 310
|
|
| Peptidase_C19 |
cd02257 |
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ... |
100-392 |
3.48e-58 |
|
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239072 [Multi-domain] Cd Length: 255 Bit Score: 190.77 E-value: 3.48e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 100 YMQQDAHEFFNYLINTISETLIQEKIAERekasrhgtlkkgnvtvnlapataglprsdekgtsernggitvegneflNKS 179
Cdd:cd02257 20 SEQQDAHEFLLFLLDKLHEELKKSSKRTS------------------------------------------------DSS 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 180 DTTTWIHEIFQGILTNETRCLSC--ETVSSKDEDFLDLSIDVEQ--NTSISHCLRVFSETETLCGDQKYFCEtCSSKQEA 255
Cdd:cd02257 52 SLKSLIHDLFGGKLESTIVCLECghESVSTEPELFLSLPLPVKGlpQVSLEDCLEKFFKEEILEGDNCYKCE-KKKKQEA 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 256 QKRMRIKKPPQLLALHLKRFKFVEPlNRHTKLSYRVVFPLELRLFN------VSDDAEYGDRMYDLVATVVHCGATPNRG 329
Cdd:cd02257 131 TKRLKIKKLPPVLIIHLKRFSFNED-GTKEKLNTKVSFPLELDLSPylsegeKDSDSDNGSYKYELVAVVVHSGTSADSG 209
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 193210244 330 HYITLVKSNSF--WLVFDDDIVEKLEVSSMEEFSGmstdaniqmppgnqsapqkNSESAYILFYQ 392
Cdd:cd02257 210 HYVAYVKDPSDgkWYKFNDDKVTEVSEEEVLEFGS-------------------LSSSAYILFYE 255
|
|
| peptidase_C19C |
cd02659 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
29-395 |
3.54e-44 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239124 [Multi-domain] Cd Length: 334 Bit Score: 156.65 E-value: 3.54e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 29 LVNALFFCRPFREKVLNYKQTLKKSGASkdNLVTCLADLFHSIASQKRRVGTIAPKRFITKL-KKENELFdnyMQQDAHE 107
Cdd:cd02659 17 LLQQLYMTPEFRNAVYSIPPTEDDDDNK--SVPLALQRLFLFLQLSESPVKTTELTDKTRSFgWDSLNTF---EQHDVQE 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 108 FFNYLINTISETLiqekiaerEKASRHGTLKKgnvtvnlapataglprsdekgtsernggitvegneflnksdtttwihe 187
Cdd:cd02659 92 FFRVLFDKLEEKL--------KGTGQEGLIKN------------------------------------------------ 115
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 188 IFQGILTNETRCLSCETVSSKDEDFLDLSIDVEQNTSISHCLRVFSETETLCGDQKYFCETCSSKQEAQKRMRIKKPPQL 267
Cdd:cd02659 116 LFGGKLVNYIICKECPHESEREEYFLDLQVAVKGKKNLEESLDAYVQGETLEGDNKYFCEKCGKKVDAEKGVCFKKLPPV 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 268 LALHLKRFKFVEPLNRHTKLSYRVVFPLEL-----------RLFNVSDDAEYGDRMYDLVATVVHCGaTPNRGHYITLVK 336
Cdd:cd02659 196 LTLQLKRFEFDFETMMRIKINDRFEFPLELdmepytekglaKKEGDSEKKDSESYIYELHGVLVHSG-DAHGGHYYSYIK 274
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 193210244 337 SNSF--WLVFDDDIVEKLEVSSMEE--FSGMSTdaniQMPPGNQSAPQKNSESAYILFYQARD 395
Cdd:cd02659 275 DRDDgkWYKFNDDVVTPFDPNDAEEecFGGEET----QKTYDSGPRAFKRTTNAYMLFYERKS 333
|
|
| Peptidase_C19E |
cd02661 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
80-391 |
2.20e-42 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239126 [Multi-domain] Cd Length: 304 Bit Score: 150.89 E-value: 2.20e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 80 TIAPKRFITKLKKENELFDNYMQQDAHEFFNYLINtisetliqekiaerekasrhgtlkkgnvtvnlAPATAGLPR-SDE 158
Cdd:cd02661 64 GSAPRIFSSNLKQISKHFRIGRQEDAHEFLRYLLD--------------------------------AMQKACLDRfKKL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 159 KGTSERnggitvegneflnkSDTTTWIHEIFQGILTNETRCLSCETVSSKDEDFLDLSIDVEQNTSISHCLRVFSETETL 238
Cdd:cd02661 112 KAVDPS--------------SQETTLVQQIFGGYLRSQVKCLNCKHVSNTYDPFLDLSLDIKGADSLEDALEQFTKPEQL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 239 CGDQKYFCETCSSKQEAQKRMRIKKPPQLLALHLKRFKFveplNRHTKLSYRVVFPLELRLFNVSDDAEYGDRMYDLVAT 318
Cdd:cd02661 178 DGENKYKCERCKKKVKASKQLTIHRAPNVLTIHLKRFSN----FRGGKINKQISFPETLDLSPYMSQPNDGPLKYKLYAV 253
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 193210244 319 VVHCGATPNRGHYITLVK-SNSFWLVFDDDiveklEVSSMEEFSGMstdaniqmppgnqsapqknSESAYILFY 391
Cdd:cd02661 254 LVHSGFSPHSGHYYCYVKsSNGKWYNMDDS-----KVSPVSIETVL-------------------SQKAYILFY 303
|
|
| Peptidase_C19R |
cd02674 |
A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
184-392 |
3.99e-41 |
|
A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239139 [Multi-domain] Cd Length: 230 Bit Score: 145.51 E-value: 3.99e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 184 WIHEI----FQGILTNETRCLSCETVSSKDEDFLDLSIDVEQNT------SISHCLRVFSETETLCGDQKYFCETCSSKQ 253
Cdd:cd02674 35 GLHSIivdlFQGQLKSRLTCLTCGKTSTTFEPFTYLSLPIPSGSgdapkvTLEDCLRLFTKEETLDGDNAWKCPKCKKKR 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 254 EAQKRMRIKKPPQLLALHLKRFKFVEPLNRhtKLSYRVVFPLE-LRLFNVSDDAEY-GDRMYDLVATVVHCGATpNRGHY 331
Cdd:cd02674 115 KATKKLTISRLPKVLIIHLKRFSFSRGSTR--KLTTPVTFPLNdLDLTPYVDTRSFtGPFKYDLYAVVNHYGSL-NGGHY 191
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 193210244 332 ITLVKSNSF--WLVFDDDIVEKLEVSSMEefsgmstdaniqmppgnqsapqknSESAYILFYQ 392
Cdd:cd02674 192 TAYCKNNETndWYKFDDSRVTKVSESSVV------------------------SSSAYILFYE 230
|
|
| Peptidase_C19L |
cd02668 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
174-391 |
1.40e-35 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239133 [Multi-domain] Cd Length: 324 Bit Score: 133.31 E-value: 1.40e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 174 EFLNKSDTTTWIHEIFQGILTNETRCLSCETVSSKDEDFLDLSIDVEQNTSISHCLRVFSETETLCGDQKYFCETCSSKQ 253
Cdd:cd02668 107 SKSKNPDLKNIVQDLFRGEYSYVTQCSKCGRESSLPSKFYELELQLKGHKTLEECIDEFLKEEQLTGDNQYFCESCNSKT 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 254 EAQKRMRIKKPPQLLALHLKRFKFVEPLNRHTKLSYRVVFPLELRLFNVSDDAEYGDRMYDLVATVVHCGATPNRGHYIT 333
Cdd:cd02668 187 DATRRIRLTTLPPTLNFQLLRFVFDRKTGAKKKLNASISFPEILDMGEYLAESDEGSYVYELSGVLIHQGVSAYSGHYIA 266
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 193210244 334 LVK--SNSFWLVFDDDIVEKLEVSSMEefsgmstDANIQMPPGNQSAPQKN----SESAYILFY 391
Cdd:cd02668 267 HIKdeQTGEWYKFNDEDVEEMPGKPLK-------LGNSEDPAKPRKSEIKKgthsSRTAYMLVY 323
|
|
| Peptidase_C19D |
cd02660 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
100-357 |
2.22e-34 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239125 [Multi-domain] Cd Length: 328 Bit Score: 130.19 E-value: 2.22e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 100 YMQQDAHEFFNYLINTIsetliqekiaerekasrHGTLKKGNvtvnlapataglprsdekgtsernggitvegNEFLNKS 179
Cdd:cd02660 86 YSQQDAHEFFQFLLDQL-----------------HTHYGGDK-------------------------------NEANDES 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 180 DTTTWIHEIFQGILTNETRCLSCETVSSKDEDFLDLSIDVEQNT---------------SISHCLRVFSETETLCGDQkY 244
Cdd:cd02660 118 HCNCIIHQTFSGSLQSSVTCQRCGGVSTTVDPFLDLSLDIPNKStpswalgesgvsgtpTLSDCLDRFTRPEKLGDFA-Y 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 245 FCETCSSKQEAQKRMRIKKPPQLLALHLKRFKFvEPLNRHTKLSYRVVFPLELRL---------FNVSDDAEYGDRMYDL 315
Cdd:cd02660 197 KCSGCGSTQEATKQLSIKKLPPVLCFQLKRFEH-SLNKTSRKIDTYVQFPLELNMtpytsssigDTQDSNSLDPDYTYDL 275
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 193210244 316 VATVVHCGaTPNRGHYITLVK-SNSFWLVFDDDIVEKLEVSSM 357
Cdd:cd02660 276 FAVVVHKG-TLDTGHYTAYCRqGDGQWFKFDDAMITRVSEEEV 317
|
|
| Peptidase_C19O |
cd02671 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
29-391 |
2.66e-32 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239136 [Multi-domain] Cd Length: 332 Bit Score: 124.62 E-value: 2.66e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 29 LVNALFFCRPFREKVlnykQTLKKSGASKDNL-VTCLA--DLFHSIAsqkrrvGTIAPKRFITKLKKENELFDNYMQQDA 105
Cdd:cd02671 39 VLQVLYFCPGFKHGL----KHLVSLISSVEQLqSSFLLnpEKYNDEL------ANQAPRRLLNALREVNPMYEGYLQHDA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 106 HEFFNYLINTISEtliqekiaerekasrhgtlkkgnvtvnlapataglprsdekgtsernggitvegneflnksdtttWI 185
Cdd:cd02671 109 QEVLQCILGNIQE-----------------------------------------------------------------LV 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 186 HEIFQGILTNETRCLSCETVSSKDEDFLDLSIDV--------EQNTSISHCLRV-----------FSETETLCGDQKYFC 246
Cdd:cd02671 124 EKDFQGQLVLRTRCLECETFTERREDFQDISVPVqeselsksEESSEISPDPKTemktlkwaisqFASVERIVGEDKYFC 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 247 ETCSSKQEAQKRMRIKKPPQLLALHLKRF----KFVEPLNRHTKLSYRVVFPLELRLFNVSDDAEYGDrmYDLVATVVHC 322
Cdd:cd02671 204 ENCHHYTEAERSLLFDKLPEVITIHLKCFaangSEFDCYGGLSKVNTPLLTPLKLSLEEWSTKPKNDV--YRLFAVVMHS 281
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 323 GATPNRGHYITLVKsnsfWLVFDDDiveklEVSSMEEFSGMstdaniqmppgNQSAPQKNSESA-YILFY 391
Cdd:cd02671 282 GATISSGHYTAYVR----WLLFDDS-----EVKVTEEKDFL-----------EALSPNTSSTSTpYLLFY 331
|
|
| Peptidase_C19K |
cd02667 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
183-392 |
4.47e-30 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239132 [Multi-domain] Cd Length: 279 Bit Score: 117.10 E-value: 4.47e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 183 TWIHEIFQGILTNETRCLSCETVSSKDEDFLDLSI----DVEQNTSISHCLRVFSETETLCGDQKYFCETCsskQEAQKR 258
Cdd:cd02667 67 TFIDSIFGGELTSTIMCESCGTVSLVYEPFLDLSLprsdEIKSECSIESCLKQFTEVEILEGNNKFACENC---TKAKKQ 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 259 MRIKKPPQLLALHLKRFkFVEPLNRHTKLSYRVVFPLELRLFNVSDDAEYGDR-----MYDLVATVVHCGaTPNRGHYIT 333
Cdd:cd02667 144 YLISKLPPVLVIHLKRF-QQPRSANLRKVSRHVSFPEILDLAPFCDPKCNSSEdkssvLYRLYGVVEHSG-TMRSGHYVA 221
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 193210244 334 LVKSNSFWLVFDDDIVEKLEVSSMEEFSGM---STDANIQMPPGNQSApqkNSEsAYILFYQ 392
Cdd:cd02667 222 YVKVRPPQQRLSDLTKSKPAADEAGPGSGQwyyISDSDVREVSLEEVL---KSE-AYLLFYE 279
|
|
| Peptidase_C19H |
cd02664 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
183-392 |
4.20e-25 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239129 [Multi-domain] Cd Length: 327 Bit Score: 104.50 E-value: 4.20e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 183 TWIHEIFQGILTNETRCLSCETVSSKDEDFLDLSIDVeqnTSISHCLRVFSETETLCGDQKYFCETCSSKQEAQKRMRIK 262
Cdd:cd02664 97 TLIEKMFGGKLSTTIRCLNCNSTSARTERFRDLDLSF---PSVQDLLNYFLSPEKLTGDNQYYCEKCASLQDAEKEMKVT 173
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 263 KPPQLLALHLKRFKFVEPLNRHTKLSYRVVFPLELRL-----FNVSDDAEYGDRM--------------YDLVATVVHCG 323
Cdd:cd02664 174 GAPEYLILTLLRFSYDQKTHVREKIMDNVSINEVLSLpvrveSKSSESPLEKKEEesgddgelvtrqvhYRLYAVVVHSG 253
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 324 ATPNRGHYITLVKSNSF----------------------WLVFDDDIVEKLEVSSMEefsgmstDANIQMPPgnqsapqk 381
Cdd:cd02664 254 YSSESGHYFTYARDQTDadstgqecpepkdaeendesknWYLFNDSRVTFSSFESVQ-------NVTSRFPK-------- 318
|
250
....*....|.
gi 193210244 382 nsESAYILFYQ 392
Cdd:cd02664 319 --DTPYILFYE 327
|
|
| COG5077 |
COG5077 |
Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, ... |
185-399 |
4.99e-19 |
|
Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 227409 [Multi-domain] Cd Length: 1089 Bit Score: 89.54 E-value: 4.99e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 185 IHEIFQGILTNETRCLSCETVSSKDEDFLDLSIDVEQNTSISHCLRVFSETETLCGDQKYFCETcSSKQEAQKRMRIKKP 264
Cdd:COG5077 300 LNGIFVGKMKSYIKCVNVNYESARVEDFWDIQLNVKGMKNLQESFRRYIQVETLDGDNRYNAEK-HGLQDAKKGVIFESL 378
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 265 PQLLALHLKRFKFVEPLNRHTKLSYRVVFPLELRLF----NVSDDAEYGDRMYDLVATVVHCGATPNrGHYITLVKS--N 338
Cdd:COG5077 379 PPVLHLQLKRFEYDFERDMMVKINDRYEFPLEIDLLpfldRDADKSENSDAVYVLYGVLVHSGDLHE-GHYYALLKPekD 457
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 193210244 339 SFWLVFDDDIVEklEVSSMEEFSGMSTDANIQMPPGNQSAPQKNSESAYILFYQARDYAAD 399
Cdd:COG5077 458 GRWYKFDDTRVT--RATEKEVLEENFGGDHPYKDKIRDHSGIKRFMSAYMLVYLRKSMLDD 516
|
|
| Peptidase_C19A |
cd02657 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
30-391 |
8.03e-18 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239122 [Multi-domain] Cd Length: 305 Bit Score: 83.53 E-value: 8.03e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 30 VNALFFCRPFREKVLNYKQTLKKSGASKDNLVTCLADLFHSIaSQKRRvgTIAPKRFITKLKK------ENELFDNYMQQ 103
Cdd:cd02657 15 LQCLRSVPELRDALKNYNPARRGANQSSDNLTNALRDLFDTM-DKKQE--PVPPIEFLQLLRMafpqfaEKQNQGGYAQQ 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 104 DAHEFFNYLINTISETLiqekiaerEKASRHGTlkkgnvtvnlapataglprsdekgtsernggitvegneflnksdttt 183
Cdd:cd02657 92 DAEECWSQLLSVLSQKL--------PGAGSKGS----------------------------------------------- 116
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 184 WIHEIFQGILTNETRCL--SCETVSSKDED-FLDLSIDVEQNTSISH--CLRVFSETETLcgdqkyFCETCSSKQEAQKR 258
Cdd:cd02657 117 FIDQLFGIELETKMKCTesPDEEEVSTESEyKLQCHISITTEVNYLQdgLKKGLEEEIEK------HSPTLGRDAIYTKT 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 259 MRIKKPPQLLALHLKRFKFVEPLNRHTKLSYRVVFPLELrlfnvsDDAEY--GDRMYDLVATVVHCGATPNRGHYITLVK 336
Cdd:cd02657 191 SRISRLPKYLTVQFVRFFWKRDIQKKAKILRKVKFPFEL------DLYELctPSGYYELVAVITHQGRSADSGHYVAWVR 264
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 193210244 337 SNSF--WLVFDDDIVEKLEVSSMEEFSGMStdaniqmppgnqsapqkNSESAYILFY 391
Cdd:cd02657 265 RKNDgkWIKFDDDKVSEVTEEDILKLSGGG-----------------DWHIAYILLY 304
|
|
| Peptidase_C19F |
cd02662 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
189-392 |
5.20e-17 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239127 [Multi-domain] Cd Length: 240 Bit Score: 79.72 E-value: 5.20e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 189 FQGILTNETRCLSCETVSSKDED-FLDLSIDVEQNTSIS-----HCLRVFSETETLCGdqkYFCETCSSKqeaqkrmrIK 262
Cdd:cd02662 56 FDGLLASRIVCLQCGESSKVRYEsFTMLSLPVPNQSSGSgttleHCLDDFLSTEIIDD---YKCDRCQTV--------IV 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 263 KPPQLLALHLKRFKFvEPLNRHTKLSYRVVFPLELRlfnvsddaeygDRMYDLVATVVHCGaTPNRGHYITLVKSNSFWl 342
Cdd:cd02662 125 RLPQILCIHLSRSVF-DGRGTSTKNSCKVSFPERLP-----------KVLYRLRAVVVHYG-SHSSGHYVCYRRKPLFS- 190
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 193210244 343 vfdDDIVEKLEVSSMEEFSGMS------TDANIQMPPGNQSAPQKnseSAYILFYQ 392
Cdd:cd02662 191 ---KDKEPGSFVRMREGPSSTShpwwriSDTTVKEVSESEVLEQK---SAYMLFYE 240
|
|
| UBP12 |
COG5560 |
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]; |
220-394 |
1.74e-16 |
|
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 227847 [Multi-domain] Cd Length: 823 Bit Score: 81.85 E-value: 1.74e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 220 EQNTSISHCLRVFSETETLCGDQKYFCETCSSKQEAQKRMRIKKPPQLLALHLKRFKFVepLNRHTKLSYRVVFPL-ELR 298
Cdd:COG5560 672 ERTITLQDCLNEFSKPEQLGLSDSWYCPGCKEFRQASKQMELWRLPMILIIHLKRFSSV--RSFRDKIDDLVEYPIdDLD 749
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 299 LFNVSDDAEYGDRMYDLVATVVHCGATPNrGHYITLVK--SNSFWLVFDDDIVEKLEvssmeefsgmstdaniqmpPGNQ 376
Cdd:COG5560 750 LSGVEYMVDDPRLIYDLYAVDNHYGGLSG-GHYTAYARnfANNGWYLFDDSRITEVD-------------------PEDS 809
|
170
....*....|....*...
gi 193210244 377 SApqknsESAYILFYQAR 394
Cdd:COG5560 810 VT-----SSAYVLFYRRK 822
|
|
| Peptidase_C19B |
cd02658 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
81-392 |
1.75e-16 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239123 [Multi-domain] Cd Length: 311 Bit Score: 79.67 E-value: 1.75e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 81 IAPKRFITKLKKENELFDNYMQQDAHEFFNYLINTIsetliqekiaEREKASRHGTlkkgnvtvnlapataglprsdekg 160
Cdd:cd02658 79 IKPSMFKALIGKGHPEFSTMRQQDALEFLLHLIDKL----------DRESFKNLGL------------------------ 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 161 tsernggitvegneflnksDTTtwihEIFQGILTNETRCLSCETVSSKDEDFLDLSIDVE--------------QNTSIS 226
Cdd:cd02658 125 -------------------NPN----DLFKFMIEDRLECLSCKKVKYTSELSEILSLPVPkdeatekeegelvyEPVPLE 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 227 HCLRVFSETETLcgdqKYFCETCSSKQEAQKRMRIKKPPQLLALHLKRFKFVE---PLnrhtKLSYRVVFPLELrlfnvs 303
Cdd:cd02658 182 DCLKAYFAPETI----EDFCSTCKEKTTATKTTGFKTFPDYLVINMKRFQLLEnwvPK----KLDVPIDVPEEL------ 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 304 ddaeyGDRMYDLVATVVHCGATPNRGHYITLVKSNSF----WLVFDDdivEKLEVSSMEEFSgmstdaniqmppgnqsap 379
Cdd:cd02658 248 -----GPGKYELIAFISHKGTSVHSGHYVAHIKKEIDgegkWVLFND---EKVVASQDPPEM------------------ 301
|
330
....*....|...
gi 193210244 380 qknSESAYILFYQ 392
Cdd:cd02658 302 ---KKLGYIYFYQ 311
|
|
| UCH_1 |
pfam13423 |
Ubiquitin carboxyl-terminal hydrolase; |
168-346 |
8.54e-15 |
|
Ubiquitin carboxyl-terminal hydrolase;
Pssm-ID: 463872 [Multi-domain] Cd Length: 305 Bit Score: 74.61 E-value: 8.54e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 168 ITVEGNEFL-NKSDTTTWIHEIFQGILTNETRCLSCETVSSKDEDFLDLSIDV----------EQNTSISHCLRVFSETE 236
Cdd:pfam13423 110 LSSEENSTPpNPSPAESPLEQLFGIDAETTIRCSNCGHESVRESSTHVLDLIYprkpssnnkkPPNQTFSSILKSSLERE 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 237 TLcgdQKYFCETCSSKQEAQKRMRIKKPPQLLALHLKRFKFVEPLNRHTKlsyrVVFPLELRLF-NVSDDAEYGDRMYDL 315
Cdd:pfam13423 190 TT---TKAWCEKCKRYQPLESRRTVRNLPPVLSLNAALTNEEWRQLWKTP----GWLPPEIGLTlSDDLQGDNEIVKYEL 262
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 193210244 316 VATVVHCGATPNRGHYITLVK---------SNSFWLVFDD 346
Cdd:pfam13423 263 RGVVVHIGDSGTSGHLVSFVKvadseledpTESQWYLFND 302
|
|
| Peptidase_C19Q |
cd02673 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
87-391 |
4.09e-12 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239138 [Multi-domain] Cd Length: 245 Bit Score: 65.63 E-value: 4.09e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 87 ITKLKKENELFDNYMQQDAHEFFNYLINTISEtlIQEKIAEREKASrhgtlkkGNVTVNLAPATAglprsdEKGTSERNG 166
Cdd:cd02673 18 LSSIGKINTEFDNDDQQDAHEFLLTLLEAIDD--IMQVNRTNVPPS-------NIEIKRLNPLEA------FKYTIESSY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 167 GITVEGNEflnksdtttwiheifqgiltnetrclscETVSSKDEDfldLSIDVEQNTSISHCLRVFSETETLCGDQKyfC 246
Cdd:cd02673 83 VCIGCSFE----------------------------ENVSDVGNF---LDVSMIDNKLDIDELLISNFKTWSPIEKD--C 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 247 ETCSSkQEAQKRMRIKKPPQLLALHLKRFKFVEPLNRHTKLSYRVVFPLELRLFNvsddaeygdrmYDLVATVVHCGATP 326
Cdd:cd02673 130 SSCKC-ESAISSERIMTFPECLSINLKRYKLRIATSDYLKKNEEIMKKYCGTDAK-----------YSLVAVICHLGESP 197
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 193210244 327 NRGHYITLVKS---NSFWLVFDDDIVEklEVSSmeefSGMSTDAniqmppgnqsapqknSESAYILFY 391
Cdd:cd02673 198 YDGHYIAYTKElynGSSWLYCSDDEIR--PVSK----NDVSTNA---------------RSSGYLIFY 244
|
|
| Peptidase_C19M |
cd02669 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
13-353 |
2.29e-10 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239134 [Multi-domain] Cd Length: 440 Bit Score: 61.95 E-value: 2.29e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 13 ISTTESVNnanehyyGLVNALFFCRPFREKVLNYKqTLKKSGASKDNLVTCLADLFHSIASQKRRVGTIAPKRFITKL-K 91
Cdd:cd02669 125 IKNNDYAN-------VIIQALSHVKPIRNFFLLYE-NYENIKDRKSELVKRLSELIRKIWNPRNFKGHVSPHELLQAVsK 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 92 KENELFDNYMQQDAHEFFNYLINTIsetliqekiaerekasrHgtlkkgnvtvnlapataglprSDEKGTSERNGGItve 171
Cdd:cd02669 197 VSKKKFSITEQSDPVEFLSWLLNTL-----------------H---------------------KDLGGSKKPNSSI--- 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 172 gneflnksdtttwIHEIFQGILTNETRCLSCETVS--SKDEDF-----------------LDL-----SIDVEQNTSISH 227
Cdd:cd02669 236 -------------IHDCFQGKVQIETQKIKPHAEEegSKDKFFkdsrvkktsvspfllltLDLpppplFKDGNEENIIPQ 302
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 228 clrvFSETETLcgdQKYFCETCSSKQEAQKRMRIKKPPQLLALHLKRF---KFVEplNRHTKLsyrVVFPLELRLFN--V 302
Cdd:cd02669 303 ----VPLKQLL---KKYDGKTETELKDSLKRYLISRLPKYLIFHIKRFsknNFFK--EKNPTI---VNFPIKNLDLSdyV 370
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 193210244 303 SDDAEYGDR--MYDLVATVVHCGATPNRGHYITLV--KSNSFWLVFDDDIVEKLE 353
Cdd:cd02669 371 HFDKPSLNLstKYNLVANIVHEGTPQEDGTWRVQLrhKSTNKWFEIQDLNVKEVL 425
|
|
| COG5533 |
COG5533 |
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]; |
254-391 |
7.03e-09 |
|
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 444284 [Multi-domain] Cd Length: 284 Bit Score: 56.73 E-value: 7.03e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 254 EAQKRMR----IKKPPQLLALHLKRFKFvepLNRHTKLSYRVVFPLELRlfnVSDDAEYGDRM---YDLVATVVHCGATp 326
Cdd:COG5533 165 EVQAKQEyevsFVKLPKILTIQLKRFAN---LGGNQKIDTEVDEKFELP---VKHDQILNIVKetyYDLVGFVLHQGSL- 237
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 193210244 327 NRGHYITLVKSNSFWLVFDDDIVEKlevSSMEEfsgmstdaniqmppgnqsAPQKNSESAYILFY 391
Cdd:COG5533 238 EGGHYIAYVKKGGKWEKANDSDVTP---VSEEE------------------AINEKAKNAYLYFY 281
|
|
| Peptidase_C19N |
cd02670 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
261-392 |
9.89e-06 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239135 [Multi-domain] Cd Length: 241 Bit Score: 46.75 E-value: 9.89e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 261 IKKPPQLLALHLKRFKFVEPLNRhtKLSYRVVFPLELRL----------------------FNVSDDAEYGDRMYDLVAT 318
Cdd:cd02670 95 FAKAPSCLIICLKRYGKTEGKAQ--KMFKKILIPDEIDIpdfvaddpracskcqlecrvcyDDKDFSPTCGKFKLSLCSA 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 319 VVHCGATPNRGHYITLVKSNSF-------------WLVFDDdiveklevssMEEFSGMSTDANIQmppgnqsaPQKNSES 385
Cdd:cd02670 173 VCHRGTSLETGHYVAFVRYGSYsltetdneaynaqWVFFDD----------MADRDGVSNGFNIP--------AARLLED 234
|
....*..
gi 193210244 386 AYILFYQ 392
Cdd:cd02670 235 PYMLFYQ 241
|
|
| Peptidase_C19P |
cd02672 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
185-392 |
7.40e-04 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239137 [Multi-domain] Cd Length: 268 Bit Score: 40.96 E-value: 7.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 185 IHEIFQGILTNETRC------LSCETVSSKDEDFLDLSID-----VEQNTSISHCLRVFSETETlcGDQKYfCETCSSKQ 253
Cdd:cd02672 68 LIQNFTRFLLETISQdqlgtpFSCGTSRNSVSLLYTLSLPlgstkTSKESTFLQLLKRSLDLEK--VTKAW-CDTCCKYQ 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210244 254 EAQKRMRIKKPPQL----LALHLKRFKFVEPLNRHTKLSY-----RVVFPLELRLFNVSDDAEYGDRMYDLVATVVHCGA 324
Cdd:cd02672 145 PLEQTTSIRHLPDIlllvLVINLSVTNGEFDDINVVLPSGkvmqnKVSPKAIDHDKLVKNRGQESIYKYELVGYVCEIND 224
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 193210244 325 TPNRGHYITLV------KSNSFWLVFDDDIVEKLevssmeefsgmstdaniqmppgnqsapqknSESAYILFYQ 392
Cdd:cd02672 225 SSRGQHNVVFVikvneeSTHGRWYLFNDFLVTPV------------------------------SELAYILLYQ 268
|
|
| |
