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Conserved domains on  [gi|71981381|ref|NP_499146|]
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Putative sodium/calcium exchanger 6 [Caenorhabditis elegans]

Protein Classification

cation/calcium exchanger( domain architecture ID 1004073)

cation/calcium exchanger belonging to the Ca(2+):cation antiporter (CaCA) family, such as mitochondrial sodium/calcium exchanger protein, an antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion

Gene Ontology:  GO:0015368|GO:0016020|GO:0070588
PubMed:  23685453
SCOP:  3002205
TCDB:  2.A.19

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN03151 super family cl33648
cation/calcium exchanger; Provisional
 65-578 2.35e-43

cation/calcium exchanger; Provisional


The actual alignment was detected with superfamily member PLN03151:

Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 164.55  E-value: 2.35e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981381   65 CEYVKCNDDnCEGGGYVLWTRYVECaSSPAVRIILIITGVIYMLVLFIMVSSAADDFFSPSISSIVAHLRISESVAGVTF 144
Cdd:PLN03151 107 CEFLKAHPI-CSSGGFFDYLKFFYC-SCEDFRILGYAVLGVWLVALFYLLGNTAADYFCCSLEKLSKLLRLPPTVAGVTL 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981381  145 MAFGNGAPDVFGAIASVLSspTPKADLALGELFGAGLFVTTMVLAVT---IFTRPFKAEVFSSIRDIAFYLVALAFLAFC 221
Cdd:PLN03151 185 LPLGNGAPDVFASIAAFVG--KDAGEVGLNSVLGGAVFVTCVVVGIVslcVADKEVQIDKRCFIRDLCFFLFTLVSLLVI 262

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981381  222 FVYyDHVEIWMPITFLGVYLIYVCTVILSQILhnRHKKDEEKVDEVKTVDTDSLEDDddiyvSHGHHVLHAHEVMKMEAE 301
Cdd:PLN03151 263 LMV-GKVTVGGAIAFVSIYVVYAFLVAANEIL--RKHARRLKLDVVTPLLPVQGSIF-----SPSVEEDESMYSPLLESD 334

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981381  302 IEAVEP-----LKTW------------SFRGVVHDFKEHlkPWPSMDEWDEMN----IFQKVIAVLN---TIPNflfKLT 357
Cdd:PLN03151 335 TESDVPrlqtsLPQWmwasnvaiysnhFAKGSVHDEERP--PWGWTDEGAEVEsslfSCSKLFSLLEmplTIPR---RLT 409

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981381  358 IPH-SEQPWSKPITLLQCLICPVFLLF--------CIQVCSISpfpnspglWMYGLILSVLLTAAVLFFTElHKEPPfYK 428
Cdd:PLN03151 410 IPIvEEDRWSKTYAVASASLAPVLLAFlwssqddvSLQARIAA--------YFIGVAIGSTLGFLAYKYTE-PDRPP-RR 479

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981381  429 SLISY--AGFLMSIAWIYLISSEVVNVVTMLGVVSRVSHEVLGLTILAWSNSIGDLIADVSVAKQGYP--RMAMAAAIGG 504
Cdd:PLN03151 480 FLIPWvlGGFIMSIVWFYMIANELVALLVAFGVIFGINPSILGLTVLAWGNSMGDLMSNVALAMNGGDgvQIAMSGCYAG 559

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 71981381  505 QLFNLLIGFGLPFTIAKIQGKSISMIINPTYRLL--MLFLAISLIFTLIAMFAQKYFLRRIHSYSLVFIYISFFVF 578
Cdd:PLN03151 560 PMFNTLVGLGMSMLLGAWSKSPESYMLPEDSSLFytMGFLVSGLIWALVVLPRNDMRPNKTLGVGLIALYLIFLTF 635
 
Name Accession Description Interval E-value
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 65-578 2.35e-43

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 164.55  E-value: 2.35e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981381   65 CEYVKCNDDnCEGGGYVLWTRYVECaSSPAVRIILIITGVIYMLVLFIMVSSAADDFFSPSISSIVAHLRISESVAGVTF 144
Cdd:PLN03151 107 CEFLKAHPI-CSSGGFFDYLKFFYC-SCEDFRILGYAVLGVWLVALFYLLGNTAADYFCCSLEKLSKLLRLPPTVAGVTL 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981381  145 MAFGNGAPDVFGAIASVLSspTPKADLALGELFGAGLFVTTMVLAVT---IFTRPFKAEVFSSIRDIAFYLVALAFLAFC 221
Cdd:PLN03151 185 LPLGNGAPDVFASIAAFVG--KDAGEVGLNSVLGGAVFVTCVVVGIVslcVADKEVQIDKRCFIRDLCFFLFTLVSLLVI 262

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981381  222 FVYyDHVEIWMPITFLGVYLIYVCTVILSQILhnRHKKDEEKVDEVKTVDTDSLEDDddiyvSHGHHVLHAHEVMKMEAE 301
Cdd:PLN03151 263 LMV-GKVTVGGAIAFVSIYVVYAFLVAANEIL--RKHARRLKLDVVTPLLPVQGSIF-----SPSVEEDESMYSPLLESD 334

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981381  302 IEAVEP-----LKTW------------SFRGVVHDFKEHlkPWPSMDEWDEMN----IFQKVIAVLN---TIPNflfKLT 357
Cdd:PLN03151 335 TESDVPrlqtsLPQWmwasnvaiysnhFAKGSVHDEERP--PWGWTDEGAEVEsslfSCSKLFSLLEmplTIPR---RLT 409

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981381  358 IPH-SEQPWSKPITLLQCLICPVFLLF--------CIQVCSISpfpnspglWMYGLILSVLLTAAVLFFTElHKEPPfYK 428
Cdd:PLN03151 410 IPIvEEDRWSKTYAVASASLAPVLLAFlwssqddvSLQARIAA--------YFIGVAIGSTLGFLAYKYTE-PDRPP-RR 479

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981381  429 SLISY--AGFLMSIAWIYLISSEVVNVVTMLGVVSRVSHEVLGLTILAWSNSIGDLIADVSVAKQGYP--RMAMAAAIGG 504
Cdd:PLN03151 480 FLIPWvlGGFIMSIVWFYMIANELVALLVAFGVIFGINPSILGLTVLAWGNSMGDLMSNVALAMNGGDgvQIAMSGCYAG 559

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 71981381  505 QLFNLLIGFGLPFTIAKIQGKSISMIINPTYRLL--MLFLAISLIFTLIAMFAQKYFLRRIHSYSLVFIYISFFVF 578
Cdd:PLN03151 560 PMFNTLVGLGMSMLLGAWSKSPESYMLPEDSSLFytMGFLVSGLIWALVVLPRNDMRPNKTLGVGLIALYLIFLTF 635
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 431-578 1.86e-22

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 93.82  E-value: 1.86e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981381   431 ISYAGFLMSIAWIYLISSEVVNVVTMLGVVSRVSHEVLGLTILAWSNSIGDLIADVSVAKQGYPRMAMAAAIGGQLFNLL 510
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 71981381   511 IGFGLPFTIAKIQGKSISMIINPTYRLLMLFLAISLIFTLIAMFAQKyfLRRIHSYSLVFIYISFFVF 578
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLLLKLDLGVLLLVALLLLLLLLLLLLPLFGR--LSRFEGLVLLLLYIVYLVF 146
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 436-585 7.69e-14

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 75.03  E-value: 7.69e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981381    436 FLMSIAWIYLISSEVVNVVTMLGVVSRVSHEVLGLTILAWSNSIGDLIADVSVAKQGYPRMAMAAAIGGQLFNLLIGFGL 515
Cdd:TIGR00927  938 FLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPV 1017

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 71981381    516 PFTI-AKIQG-KSISMIINPTY-RLLMLFLAisLIFTLIAMFAQKYFLRRIHSYSLVFIYISFFVfIGLSLDD 585
Cdd:TIGR00927 1018 PWLLfSLINGlQPVPVSSNGLFcAIVLLFLM--LLFVISSIASCKWRMNKILGFTMFLLYFVFLI-ISVMLED 1087
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
120-268 2.07e-12

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 67.85  E-value: 2.07e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981381 120 DFFSPSISSIVAHLRISESVAGVTFMAFGNGAPDVFGAIASVLSSptpKADLALGELFGAGLFVTTMVLAVTIFTRPFKA 199
Cdd:COG0530   2 DLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDG---SPDIAVGNVVGSNIANILLILGLAALIRPLAV 78

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 71981381 200 EVFSSIRDIAFYLVAlAFLAFCFVYYDHVEIWMPITFLGVYLIYVCTVILSQILHNRHKKDEEKVDEVK 268
Cdd:COG0530  79 DRRVLRRDLPFLLLA-SLLLLALLLDGTLSRIDGVILLLLYVLYLYYLIRRARKEPAWEEVEEELEEKP 146
 
Name Accession Description Interval E-value
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 65-578 2.35e-43

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 164.55  E-value: 2.35e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981381   65 CEYVKCNDDnCEGGGYVLWTRYVECaSSPAVRIILIITGVIYMLVLFIMVSSAADDFFSPSISSIVAHLRISESVAGVTF 144
Cdd:PLN03151 107 CEFLKAHPI-CSSGGFFDYLKFFYC-SCEDFRILGYAVLGVWLVALFYLLGNTAADYFCCSLEKLSKLLRLPPTVAGVTL 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981381  145 MAFGNGAPDVFGAIASVLSspTPKADLALGELFGAGLFVTTMVLAVT---IFTRPFKAEVFSSIRDIAFYLVALAFLAFC 221
Cdd:PLN03151 185 LPLGNGAPDVFASIAAFVG--KDAGEVGLNSVLGGAVFVTCVVVGIVslcVADKEVQIDKRCFIRDLCFFLFTLVSLLVI 262

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981381  222 FVYyDHVEIWMPITFLGVYLIYVCTVILSQILhnRHKKDEEKVDEVKTVDTDSLEDDddiyvSHGHHVLHAHEVMKMEAE 301
Cdd:PLN03151 263 LMV-GKVTVGGAIAFVSIYVVYAFLVAANEIL--RKHARRLKLDVVTPLLPVQGSIF-----SPSVEEDESMYSPLLESD 334

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981381  302 IEAVEP-----LKTW------------SFRGVVHDFKEHlkPWPSMDEWDEMN----IFQKVIAVLN---TIPNflfKLT 357
Cdd:PLN03151 335 TESDVPrlqtsLPQWmwasnvaiysnhFAKGSVHDEERP--PWGWTDEGAEVEsslfSCSKLFSLLEmplTIPR---RLT 409

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981381  358 IPH-SEQPWSKPITLLQCLICPVFLLF--------CIQVCSISpfpnspglWMYGLILSVLLTAAVLFFTElHKEPPfYK 428
Cdd:PLN03151 410 IPIvEEDRWSKTYAVASASLAPVLLAFlwssqddvSLQARIAA--------YFIGVAIGSTLGFLAYKYTE-PDRPP-RR 479

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981381  429 SLISY--AGFLMSIAWIYLISSEVVNVVTMLGVVSRVSHEVLGLTILAWSNSIGDLIADVSVAKQGYP--RMAMAAAIGG 504
Cdd:PLN03151 480 FLIPWvlGGFIMSIVWFYMIANELVALLVAFGVIFGINPSILGLTVLAWGNSMGDLMSNVALAMNGGDgvQIAMSGCYAG 559

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 71981381  505 QLFNLLIGFGLPFTIAKIQGKSISMIINPTYRLL--MLFLAISLIFTLIAMFAQKYFLRRIHSYSLVFIYISFFVF 578
Cdd:PLN03151 560 PMFNTLVGLGMSMLLGAWSKSPESYMLPEDSSLFytMGFLVSGLIWALVVLPRNDMRPNKTLGVGLIALYLIFLTF 635
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 431-578 1.86e-22

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 93.82  E-value: 1.86e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981381   431 ISYAGFLMSIAWIYLISSEVVNVVTMLGVVSRVSHEVLGLTILAWSNSIGDLIADVSVAKQGYPRMAMAAAIGGQLFNLL 510
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 71981381   511 IGFGLPFTIAKIQGKSISMIINPTYRLLMLFLAISLIFTLIAMFAQKyfLRRIHSYSLVFIYISFFVF 578
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLLLKLDLGVLLLVALLLLLLLLLLLLPLFGR--LSRFEGLVLLLLYIVYLVF 146
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 105-249 8.28e-20

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 86.12  E-value: 8.28e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981381   105 IYMLVLFIMVSSAADDFFSPSISSIVAHLRISESVAGVTFMAFGNGAPDVFGAIASVLsspTPKADLALGELFGAGLFVT 184
Cdd:pfam01699   3 LLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAAL---RGEPDLALGNVIGSNIFNI 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981381   185 TMVLAVTIFTRPFKAEVFSSIRDI-AFYLVALAFLAFCFVYY----DHVEIWMPITFLGVYLIYVCTVIL 249
Cdd:pfam01699  80 LLVLGLSALIGPVKVDSLLLKLDLgVLLLVALLLLLLLLLLLlplfGRLSRFEGLVLLLLYIVYLVFQIV 149
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 436-585 7.69e-14

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 75.03  E-value: 7.69e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981381    436 FLMSIAWIYLISSEVVNVVTMLGVVSRVSHEVLGLTILAWSNSIGDLIADVSVAKQGYPRMAMAAAIGGQLFNLLIGFGL 515
Cdd:TIGR00927  938 FLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPV 1017

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 71981381    516 PFTI-AKIQG-KSISMIINPTY-RLLMLFLAisLIFTLIAMFAQKYFLRRIHSYSLVFIYISFFVfIGLSLDD 585
Cdd:TIGR00927 1018 PWLLfSLINGlQPVPVSSNGLFcAIVLLFLM--LLFVISSIASCKWRMNKILGFTMFLLYFVFLI-ISVMLED 1087
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 97-247 9.94e-13

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 71.18  E-value: 9.94e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981381     97 IILIITGVIYMLVLFIMVssaADDFFSPSISSIVAHLRISESVAGVTFMAFGNGAPDVFGAIASVLSSptpKADLALGEL 176
Cdd:TIGR00927  457 VVLHIFGMMYVFVALAIV---CDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFIS---HSNVGIGTI 530

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71981381    177 FGAGLFVTTMVLAV-TIFTRP-FKAEVFSSIRDIAFYLVALAFLAFCFVyyDH-VEIWMPITFLGVYLIYVCTV 247
Cdd:TIGR00927  531 VGSAVFNILFVIGTcALFSREiLNLTWWPLFRDVSFYILDLMMLILFFL--DSlIAWWESLLLLLAYALYVFTM 602
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
120-268 2.07e-12

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 67.85  E-value: 2.07e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981381 120 DFFSPSISSIVAHLRISESVAGVTFMAFGNGAPDVFGAIASVLSSptpKADLALGELFGAGLFVTTMVLAVTIFTRPFKA 199
Cdd:COG0530   2 DLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDG---SPDIAVGNVVGSNIANILLILGLAALIRPLAV 78

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 71981381 200 EVFSSIRDIAFYLVAlAFLAFCFVYYDHVEIWMPITFLGVYLIYVCTVILSQILHNRHKKDEEKVDEVK 268
Cdd:COG0530  79 DRRVLRRDLPFLLLA-SLLLLALLLDGTLSRIDGVILLLLYVLYLYYLIRRARKEPAWEEVEEELEEKP 146
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
104-244 1.22e-10

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 62.84  E-value: 1.22e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981381 104 VIYMLVLFIMVSSAADdFFSPSISSIVAHLRISESVAGVTFMAFGNGAPDVFGAIASVLSSptpKADLALGELFGAGLFV 183
Cdd:COG0530 154 LLLLVLGLALLVVGAR-LLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKG---EDDLAVGNIIGSNIFN 229

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 71981381 184 TTMVLAVTIFTRPFKAEVFSSIRDIAFyLVALAFLAFCFVYYDH-VEIWMPITFLGVYLIYV 244
Cdd:COG0530 230 ILLVLGIGALITPIPVDPAVLSFDLPV-MLAATLLLLGLLRTGGrIGRWEGLLLLALYLAYL 290
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 104-266 1.89e-10

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 62.34  E-value: 1.89e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981381   104 VIYMLVLFIMVSSAADDFFSPSISSIVAHLRISESVAGVTFMAFGNGAPDVFGAIASVLSSptpKADLALGELFGAGLFV 183
Cdd:TIGR00367   3 LIGYLILGLILLIYGADLFVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMG---QPDIGVGNVIGSNIFN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981381   184 TTMVLAVTIFTRPFKAEVFSSIRDIAFYLVALAFLAFcFVYYDHVEIWMPITFLGVYLIYVCTVILSQILHNRHKKDEEK 263
Cdd:TIGR00367  80 ILLILGLSAIFSPIIVDKDWLRRDILFYLLVSILLLF-FGLDGQISRIDGVVLLILYIVYLLFLVKNERWVKYDTYTEEN 158


                  ...
gi 71981381   264 VDE 266
Cdd:TIGR00367 159 LDE 161
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 419-575 1.58e-09

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 59.64  E-value: 1.58e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981381   419 ELHKEPPFYKSLISYAGFLmsiAWIYLISSEVVNVVTMLGVVSRVSHEVLGLTILAWSNSIGDLIADVSVAKQGYPRMAM 498
Cdd:TIGR00367 161 ENNRRPQIFFSLVLLIIGL---IGLVVGSRLLVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSLAAARKGLGDIAV 237

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 71981381   499 AAAIGGQLFNLLIGFGLPFTIAKIQGKSISMIINptyrlLMLFLAISLIFTLIAMFAQKyfLRRIHSYSLVFIYISF 575
Cdd:TIGR00367 238 GNVIGSNIFNILVGLGVPSLFMPIPVEPLAYNLD-----APVMVIVTLLLMLFFKTSMK--LGRWEGILLLALYIAY 307
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
451-579 4.54e-06

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 48.59  E-value: 4.54e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981381 451 VNVVTMLGVVSRVSHEVLGLTILAWSNSIGDLIADVSVAKQGYPRMAMAAAIGGQLFNLLIGFGLPFTIAKIQGKSISMi 530
Cdd:COG0530   5 VRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRPLAVDRRVL- 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 71981381 531 inptYRLLMLFLAISLIFTLIAMFAQkyfLRRIHSYSLVFIYISFFVFI 579
Cdd:COG0530  84 ----RRDLPFLLLASLLLLALLLDGT---LSRIDGVILLLLYVLYLYYL 125
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 100-310 1.37e-05

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 48.25  E-value: 1.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981381   100 IITGVIY---MLVLFIMVSSAADDFFS----------------PSISSIVAHLRI-SESVAGVTFMAFGNGAPDVFGAIA 159
Cdd:TIGR00845  72 IARATVYfvaMVYMFLGVSIIADRFMAsievitsqekeitikkPNGETTVTTVRIwNETVSNLTLMALGSSAPEILLSVI 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981381   160 SVLSSPTPKADLALGELFGAGLFVTTMVLAVTIFTRPfKAEVfSSIRDIAFYLVALAFLAFCFVY---------YDHVEI 230
Cdd:TIGR00845 152 EVCGHNFEAGDLGPSTIVGSAAFNMFIIIAICVYVIP-DGET-RKIKHLRVFFVTAAWSVFAYVWlylilavfsPGVVEV 229

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981381   231 WMPI-TF----LGVYLIYVCT--VILSQILHNRHKKDEekvdevktvdtdsleddddiyvSHGHHVLHAHEVMKMEAEIE 303
Cdd:TIGR00845 230 WEGLlTFfffpLCVVFAWVADrrLLFYKYVYKRYRAGK----------------------QRGMIIETEGDRPKSKTEIE 287


                  ....*..
gi 71981381   304 AVEPLKT 310
Cdd:TIGR00845 288 MDGKMVN 294
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 94-243 2.10e-05

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 46.55  E-value: 2.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981381    94 AVRIILIITGVIYMLVL-FIMVSSAAddffspsisSIVAHLRISESVAGVTFMAFGNGAPDVfgaIASVLSSPTPKADLA 172
Cdd:TIGR00367 169 FFSLVLLIIGLIGLVVGsRLLVDGAV---------KIAEILGISEKIIGLTLLAIGTSLPEL---VVSLAAARKGLGDIA 236

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 71981381   173 LGELFGAGLFVTTMVLAVTIFTRPFKAEVFSSIRDIAFYLVALAFLAFCFVYYDHVEIWMPITFLGVYLIY 243
Cdd:TIGR00367 237 VGNVIGSNIFNILVGLGVPSLFMPIPVEPLAYNLDAPVMVIVTLLLMLFFKTSMKLGRWEGILLLALYIAY 307
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 450-551 3.11e-03

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 40.01  E-value: 3.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981381  450 VVNVVTMLGVVSRVSHEVLGLTILAWSNSIGDLIADVSVAKQGYPRMAMAAAIGGQLFNLLIGFGLPFTIAkiqgksiSM 529
Cdd:PRK10734 193 VIDNATVLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIVLGLPALIS-------PG 265

                         90       100
                 ....*....|....*....|....
gi 71981381  530 IINPT--YRLLMLFLAISLIFTLI 551
Cdd:PRK10734 266 EINPLafSRDYWVMLLVSVIFALL 289
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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