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Conserved domains on  [gi|17553810|ref|NP_499014|]
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glp-1/Notch intracellular domain [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
945-1172 7.59e-35

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 135.47  E-value: 7.59e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810  945 AIRCLKAGADVNARDCDENTALMLAVRAHRVRLSVVLLREGANPTIFNNSERSALHEAVVNKDLRILRHLLtDKRLlkEI 1024
Cdd:COG0666   70 ALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLL-EAGA--DV 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810 1025 DELDRNGMTALMLVARelgKHQVEMAELLLSKGAKLDYdgaarKDSNkykGRTALHYAAMHDNEEMVIMLVRRSSNKDKQ 1104
Cdd:COG0666  147 NAQDNDGNTPLHLAAA---NGNLEIVKLLLEAGADVNA-----RDND---GETPLHLAAENGHLEIVKLLLEAGADVNAK 215

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17553810 1105 DEDGRTPIMLAAKEGCEKTVQYLALNDASLGIVDSMDMTAAQVAEASYHHELAAFLRQVANERHRNDI 1172
Cdd:COG0666  216 DNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALL 283
NOD pfam06816
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 611-665 1.48e-15

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be elucidated.


:

Pssm-ID: 462014  Cd Length: 56  Bit Score: 71.78  E-value: 1.48e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 17553810    611 TEAIILSDIRIKVQIDPIEFQATGGETLMQISANLRATVRIQRDELG-PLVFRWDG 665
Cdd:pfam06816    1 PEKLAEGVLVIVVLMDPEELLNNSVQFLRELSTVLRTNVRFKKDENGnPMIYPWYG 56
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 533-568 7.36e-10

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


:

Pssm-ID: 459658  Cd Length: 35  Bit Score: 55.23  E-value: 7.36e-10
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 17553810    533 FSKCQYPaRCADQFANGVCNQECNNEECLYDGLDCQ 568
Cdd:pfam00066    1 WPNCPYP-YCWDKFGNGVCDEECNNAECLWDGGDCS 35
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 489-526 1.39e-08

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


:

Pssm-ID: 197463  Cd Length: 38  Bit Score: 51.56  E-value: 1.39e-08
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 17553810     489 ETVIRDLCEQRKCMDLASNGICNPECNLEECNFDGGDC 526
Cdd:smart00004    1 PQDPWSRCEDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 232-269 4.41e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.33  E-value: 4.41e-08
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 17553810  232 DKNECLIEETCVNNSTCFNLHGDFTCTCKPGYAGKYCE 269
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 369-406 1.12e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 1.12e-05
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 17553810  369 DIQSCK-YNPCVNNATCIDLKNSgYSCHCPLGFYGLNCE 406
Cdd:cd00054    1 DIDECAsGNPCQNGGTCVNTVGS-YRCSCPPGYTGRNCE 38
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 573-608 1.21e-05

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


:

Pssm-ID: 459658  Cd Length: 35  Bit Score: 43.29  E-value: 1.21e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 17553810    573 RCPAHirkHCIERRGDGVCNLECSFIGCGFDGGDCN 608
Cdd:pfam00066    3 NCPYP---YCWDKFGNGVCDEECNNAECLWDGGDCS 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 155-190 1.03e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.03e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 17553810  155 IDHCAQ-NECAEGSTCVNSVYNYYCDCPIGKSGRYCE 190
Cdd:cd00054    2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 451-479 1.64e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.64e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 17553810  451 SRHPCKNGGVCKNTG---YCECQYGYTGPTCE 479
Cdd:cd00054    7 SGNPCQNGGTCVNTVgsyRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 118-152 1.94e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.94e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 17553810  118 VNPCDS-DPC-NNGLCYPFYGGFQCICNNGYGGSYCE 152
Cdd:cd00054    2 IDECASgNPCqNGGTCVNTVGSYRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
945-1172 7.59e-35

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 135.47  E-value: 7.59e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810  945 AIRCLKAGADVNARDCDENTALMLAVRAHRVRLSVVLLREGANPTIFNNSERSALHEAVVNKDLRILRHLLtDKRLlkEI 1024
Cdd:COG0666   70 ALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLL-EAGA--DV 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810 1025 DELDRNGMTALMLVARelgKHQVEMAELLLSKGAKLDYdgaarKDSNkykGRTALHYAAMHDNEEMVIMLVRRSSNKDKQ 1104
Cdd:COG0666  147 NAQDNDGNTPLHLAAA---NGNLEIVKLLLEAGADVNA-----RDND---GETPLHLAAENGHLEIVKLLLEAGADVNAK 215

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17553810 1105 DEDGRTPIMLAAKEGCEKTVQYLALNDASLGIVDSMDMTAAQVAEASYHHELAAFLRQVANERHRNDI 1172
Cdd:COG0666  216 DNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALL 283
NOD pfam06816
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 611-665 1.48e-15

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be elucidated.


Pssm-ID: 462014  Cd Length: 56  Bit Score: 71.78  E-value: 1.48e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 17553810    611 TEAIILSDIRIKVQIDPIEFQATGGETLMQISANLRATVRIQRDELG-PLVFRWDG 665
Cdd:pfam06816    1 PEKLAEGVLVIVVLMDPEELLNNSVQFLRELSTVLRTNVRFKKDENGnPMIYPWYG 56
Ank_2 pfam12796
Ankyrin repeats (3 copies);
999-1105 7.20e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 71.30  E-value: 7.20e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810    999 LHEAVVNKDLRILRHLLTDKrllKEIDELDRNGMTALMLVARelgKHQVEMAELLLSKGAKldydgaarkdSNKYKGRTA 1078
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENG---ADANLQDKNGRTALHLAAK---NGHLEIVKLLLEHADV----------NLKDNGRTA 64

                           90       100
                   ....*....|....*....|....*..
gi 17553810   1079 LHYAAMHDNEEMVIMLVRRSSNKDKQD 1105
Cdd:pfam12796   65 LHYAARSGHLEIVKLLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 913-1115 1.25e-12

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 71.59  E-value: 1.25e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810   913 SVNQVDsKYRRRVLHWLAANVRGKPeDVITTeairCLKAGADVNARDCDENTALMLAVRAHRVRLSVV--LLREGANPTI 990
Cdd:PHA03095  109 DVNAKD-KVGRTPLHVYLSGFNINP-KVIRL----LLRKGADVNALDLYGMTPLAVLLKSRNANVELLrlLIDAGADVYA 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810   991 FNNSERSALHEAVVN--KDLRILRHLLtdkRLLKEIDELDRNGMTALMLVARELGKHQVEMAELLLsKGAKLDYdgaark 1068
Cdd:PHA03095  183 VDDRFRSLLHHHLQSfkPRARIVRELI---RAGCDPAATDMLGNTPLHSMATGSSCKRSLVLPLLI-AGISINA------ 252

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 17553810  1069 dSNKYkGRTALHYAAMHDNEEMVIMLVRRSSNKDKQDEDGRTPIMLA 1115
Cdd:PHA03095  253 -RNRY-GQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLM 297
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 533-568 7.36e-10

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 55.23  E-value: 7.36e-10
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 17553810    533 FSKCQYPaRCADQFANGVCNQECNNEECLYDGLDCQ 568
Cdd:pfam00066    1 WPNCPYP-YCWDKFGNGVCDEECNNAECLWDGGDCS 35
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 530-567 1.11e-08

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 51.94  E-value: 1.11e-08
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 17553810     530 QRPFSKCQYpARCADQFANGVCNQECNNEECLYDGLDC 567
Cdd:smart00004    2 QDPWSRCED-AQCWDKFGDGVCDEECNNAECLWDGGDC 38
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 489-526 1.39e-08

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 51.56  E-value: 1.39e-08
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 17553810     489 ETVIRDLCEQRKCMDLASNGICNPECNLEECNFDGGDC 526
Cdd:smart00004    1 PQDPWSRCEDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 232-269 4.41e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.33  E-value: 4.41e-08
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 17553810  232 DKNECLIEETCVNNSTCFNLHGDFTCTCKPGYAGKYCE 269
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 496-527 1.30e-07

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 48.68  E-value: 1.30e-07
                           10        20        30
                   ....*....|....*....|....*....|..
gi 17553810    496 CEQRKCMDLASNGICNPECNLEECNFDGGDCS 527
Cdd:pfam00066    4 CPYPYCWDKFGNGVCDEECNNAECLWDGGDCS 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
232-269 6.37e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.86  E-value: 6.37e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 17553810     232 DKNECLIEETCVNNSTCFNLHGDFTCTCKPGY-AGKYCE 269
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 955-1166 8.03e-06

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 50.46  E-value: 8.03e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810    955 VNARDCDENTALMLAVRAHRVRLSVVLLREGANPTIFNNS-----ERSALHEAVV---NKDLRILrhlltdkrlLKEIDE 1026
Cdd:TIGR00870    7 VPAEESPLSDEEKAFLPAAERGDLASVYRDLEEPKKLNINcpdrlGRSALFVAAIeneNLELTEL---------LLNLSC 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810   1027 LDRNGMTALMLVARELgKHQVEMAELLLSKGAKLDYDGA---ARKDSNKYKGRTALHYAAMHDNEEMVIMLVRRSSN--- 1100
Cdd:TIGR00870   78 RGAVGDTLLHAISLEY-VDAVEAILLHLLAAFRKSGPLElanDQYTSEFTPGITALHLAAHRQNYEIVKLLLERGASvpa 156

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17553810   1101 -------KDKQDED----GRTPIMLAAKEGCEKTVQYLALNDASLGIVDSMDMTA--AQVAEASYHHELAAFLRQVANE 1166
Cdd:TIGR00870  157 racgdffVKSQGVDsfyhGESPLNAAACLGSPSIVALLSEDPADILTADSLGNTLlhLLVMENEFKAEYEELSCQMYNF 235
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 369-406 1.12e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 1.12e-05
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 17553810  369 DIQSCK-YNPCVNNATCIDLKNSgYSCHCPLGFYGLNCE 406
Cdd:cd00054    1 DIDECAsGNPCQNGGTCVNTVGS-YRCSCPPGYTGRNCE 38
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 573-608 1.21e-05

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 43.29  E-value: 1.21e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 17553810    573 RCPAHirkHCIERRGDGVCNLECSFIGCGFDGGDCN 608
Cdd:pfam00066    3 NCPYP---YCWDKFGNGVCDEECNNAECLWDGGDCS 35
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 567-607 4.43e-05

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 41.93  E-value: 4.43e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 17553810     567 CQSELFRCPAhirKHCIERRGDGVCNLECSFIGCGFDGGDC 607
Cdd:smart00004    1 PQDPWSRCED---AQCWDKFGDGVCDEECNNAECLWDGGDC 38
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 1074-1103 1.07e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 40.26  E-value: 1.07e-04
                            10        20        30
                    ....*....|....*....|....*....|
gi 17553810    1074 KGRTALHYAAMHDNEEMVIMLVRRSSNKDK 1103
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
369-406 1.99e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 1.99e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 17553810     369 DIQSCK-YNPCVNNATCIDLKNSgYSCHCPLGFY-GLNCE 406
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGS-YRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 155-190 1.03e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.03e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 17553810  155 IDHCAQ-NECAEGSTCVNSVYNYYCDCPIGKSGRYCE 190
Cdd:cd00054    2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 451-479 1.64e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.64e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 17553810  451 SRHPCKNGGVCKNTG---YCECQYGYTGPTCE 479
Cdd:cd00054    7 SGNPCQNGGTCVNTVgsyRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 118-152 1.94e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.94e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 17553810  118 VNPCDS-DPC-NNGLCYPFYGGFQCICNNGYGGSYCE 152
Cdd:cd00054    2 IDECASgNPCqNGGTCVNTVGSYRCSCPPGYTGRNCE 38
TRPV1 cd22196
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 ...
 995-1166 4.09e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 (TRPV1), a capsaicin (vanilloid) receptor, is the founding member of the vanilloid TRP subfamily (TRPV). In humans, it is expressed in the brain, kidney, pancreas, testis, uterus, spleen, stomach, small intestine, lung and liver. TRPV1 has been implicated to have function in thermo-sensation (heat), autonomic thermoregulation, nociception, food intake regulation, and multiple functions in the gastrointestinal (GI) tract. The receptor has also been involved in growth cone guidance, long-term depression, endocannabinoid signaling and osmosensing in the central nervous system. TRPV1 is up regulated in several human pathological conditions including vulvodynia, GI inflammation, Crohn's disease and ulcerative colitis. TRPV1 knock-out mice exhibit impaired sensation to thermal-mechanical acute pain. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411980 [Multi-domain]  Cd Length: 649  Bit Score: 41.33  E-value: 4.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810  995 ERSALHEAVVNKDLRILRHLL-----TDKRLLKEIDELDRNGMTALMLVARELGKHQVEMAELLLSKGAKLDY----DGA 1065
Cdd:cd22196    6 DRRRIFDAVAKGDCKELDGLLeylmrTKKRLTDSEFKDPETGKTCLLKAMLNLHNGQNDTISLLLDIAEKTGNlkefVNA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810 1066 ARKDsNKYKGRTALHYAAMHDNEEMVIMLVRRSSN----------KDKQDED----GRTPIMLAAKEGCEKTVQYLALND 1131
Cdd:cd22196   86 AYTD-SYYKGQTALHIAIERRNMHLVELLVQNGADvharasgeffKKKKGGPgfyfGELPLSLAACTNQLDIVKFLLENP 164

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 17553810 1132 ---ASLGIVDSMDMTA--AQVAEASYHHELAAFLRQVANE 1166
Cdd:cd22196  165 hspADISARDSMGNTVlhALVEVADNTPENTKFVTKMYNE 204
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 373-404 7.32e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 7.32e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 17553810    373 CKYNPCVNNATCIDLKNsGYSCHCPLGFYGLN 404
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPG-GYTCICPEGYTGKR 31
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
945-1172 7.59e-35

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 135.47  E-value: 7.59e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810  945 AIRCLKAGADVNARDCDENTALMLAVRAHRVRLSVVLLREGANPTIFNNSERSALHEAVVNKDLRILRHLLtDKRLlkEI 1024
Cdd:COG0666   70 ALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLL-EAGA--DV 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810 1025 DELDRNGMTALMLVARelgKHQVEMAELLLSKGAKLDYdgaarKDSNkykGRTALHYAAMHDNEEMVIMLVRRSSNKDKQ 1104
Cdd:COG0666  147 NAQDNDGNTPLHLAAA---NGNLEIVKLLLEAGADVNA-----RDND---GETPLHLAAENGHLEIVKLLLEAGADVNAK 215

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17553810 1105 DEDGRTPIMLAAKEGCEKTVQYLALNDASLGIVDSMDMTAAQVAEASYHHELAAFLRQVANERHRNDI 1172
Cdd:COG0666  216 DNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALL 283
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
944-1172 4.88e-34

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 133.16  E-value: 4.88e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810  944 EAIRCLKAGADVNARDCDENTALMLAVRAHRVRLSVVLLREGANPTIFNNSERSALHEAVVNKDLRILRHLLTDKrllKE 1023
Cdd:COG0666   36 LLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAG---AD 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810 1024 IDELDRNGMTALMLVARelgKHQVEMAELLLSKGAKLDydgaaRKDSNkykGRTALHYAAMHDNEEMVIMLVRRSSNKDK 1103
Cdd:COG0666  113 VNARDKDGETPLHLAAY---NGNLEIVKLLLEAGADVN-----AQDND---GNTPLHLAAANGNLEIVKLLLEAGADVNA 181

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17553810 1104 QDEDGRTPIMLAAKEGCEKTVQYLALNDASLGIVDSMDMTAAQVAEASYHHELAAFLRQVANERHRNDI 1172
Cdd:COG0666  182 RDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDK 250
NOD pfam06816
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 611-665 1.48e-15

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be elucidated.


Pssm-ID: 462014  Cd Length: 56  Bit Score: 71.78  E-value: 1.48e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 17553810    611 TEAIILSDIRIKVQIDPIEFQATGGETLMQISANLRATVRIQRDELG-PLVFRWDG 665
Cdd:pfam06816    1 PEKLAEGVLVIVVLMDPEELLNNSVQFLRELSTVLRTNVRFKKDENGnPMIYPWYG 56
Ank_2 pfam12796
Ankyrin repeats (3 copies);
999-1105 7.20e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 71.30  E-value: 7.20e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810    999 LHEAVVNKDLRILRHLLTDKrllKEIDELDRNGMTALMLVARelgKHQVEMAELLLSKGAKldydgaarkdSNKYKGRTA 1078
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENG---ADANLQDKNGRTALHLAAK---NGHLEIVKLLLEHADV----------NLKDNGRTA 64

                           90       100
                   ....*....|....*....|....*..
gi 17553810   1079 LHYAAMHDNEEMVIMLVRRSSNKDKQD 1105
Cdd:pfam12796   65 LHYAARSGHLEIVKLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1035-1138 1.02e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 67.83  E-value: 1.02e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810   1035 LMLVARelgKHQVEMAELLLSKGAKldydgaarKDSNKYKGRTALHYAAMHDNEEMVIMLVRRSsNKDKQDeDGRTPIML 1114
Cdd:pfam12796    1 LHLAAK---NGNLELVKLLLENGAD--------ANLQDKNGRTALHLAAKNGHLEIVKLLLEHA-DVNLKD-NGRTALHY 67

                           90       100
                   ....*....|....*....|....
gi 17553810   1115 AAKEGCEKTVQYLALNDASLGIVD 1138
Cdd:pfam12796   68 AARSGHLEIVKLLLEKGADINVKD 91
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
998-1160 2.59e-13

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 71.91  E-value: 2.59e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810  998 ALHEAVVNKDLRILRHLLTDKRLLKEIDELDRNGMTALMLVARELGKHQVEMAELLLSKGAKLDYDGAARKDSNKYKGRT 1077
Cdd:COG0666   10 LLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNT 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810 1078 ALHYAAMHDNEEMVIMLVRRSSNKDKQDEDGRTPIMLAAKEGCEKTVQYLALNDASLGIVDSMDMTAAQVAEASYHHELA 1157
Cdd:COG0666   90 LLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIV 169


                 ...
gi 17553810 1158 AFL 1160
Cdd:COG0666  170 KLL 172
PHA03095 PHA03095
ankyrin-like protein; Provisional
 913-1115 1.25e-12

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 71.59  E-value: 1.25e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810   913 SVNQVDsKYRRRVLHWLAANVRGKPeDVITTeairCLKAGADVNARDCDENTALMLAVRAHRVRLSVV--LLREGANPTI 990
Cdd:PHA03095  109 DVNAKD-KVGRTPLHVYLSGFNINP-KVIRL----LLRKGADVNALDLYGMTPLAVLLKSRNANVELLrlLIDAGADVYA 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810   991 FNNSERSALHEAVVN--KDLRILRHLLtdkRLLKEIDELDRNGMTALMLVARELGKHQVEMAELLLsKGAKLDYdgaark 1068
Cdd:PHA03095  183 VDDRFRSLLHHHLQSfkPRARIVRELI---RAGCDPAATDMLGNTPLHSMATGSSCKRSLVLPLLI-AGISINA------ 252

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 17553810  1069 dSNKYkGRTALHYAAMHDNEEMVIMLVRRSSNKDKQDEDGRTPIMLA 1115
Cdd:PHA03095  253 -RNRY-GQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLM 297
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1079-1160 2.82e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 60.90  E-value: 2.82e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810   1079 LHYAAMHDNEEMVIMLVRRSSNKDKQDEDGRTPIMLAAKEGCEKTVQYLaLNDASLGIVDSmDMTAAQVAEASYHHELAA 1158
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLL-LEHADVNLKDN-GRTALHYAARSGHLEIVK 78


                   ..
gi 17553810   1159 FL 1160
Cdd:pfam12796   79 LL 80
PHA03095 PHA03095
ankyrin-like protein; Provisional
 949-1162 9.34e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 65.82  E-value: 9.34e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810   949 LKAGADVNARDCDENTALMLAVRAHRVRLSVV--LLREGANPTIFNNSERSALHEAVVNK--DLRILRhLLTDKrlLKEI 1024
Cdd:PHA03095  104 IKAGADVNAKDKVGRTPLHVYLSGFNINPKVIrlLLRKGADVNALDLYGMTPLAVLLKSRnaNVELLR-LLIDA--GADV 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810  1025 DELDRNGMTALMLVARELGKHQVEMAELLlskgaKLDYDGAARKDSnkykGRTALHYAAMHDNEEMVIM--LVRRSSNKD 1102
Cdd:PHA03095  181 YAVDDRFRSLLHHHLQSFKPRARIVRELI-----RAGCDPAATDML----GNTPLHSMATGSSCKRSLVlpLLIAGISIN 251

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17553810  1103 KQDEDGRTPIMLAAKEGCEKTVQYLALNDASLGIVDSMDMTAaqVAEA---SYHHELAAFLRQ 1162
Cdd:PHA03095  252 ARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTP--LSLMvrnNNGRAVRAALAK 312
Ank_2 pfam12796
Ankyrin repeats (3 copies);
966-1061 3.85e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 57.82  E-value: 3.85e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810    966 LMLAVRAHRVRLSVVLLREGANPTIFNNSERSALHEAVVNKDLRILrhlltdKRLLKEID-ELDRNGMTALMLVARelgK 1044
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIV------KLLLEHADvNLKDNGRTALHYAAR---S 71

                           90
                   ....*....|....*..
gi 17553810   1045 HQVEMAELLLSKGAKLD 1061
Cdd:pfam12796   72 GHLEIVKLLLEKGADIN 88
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 533-568 7.36e-10

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 55.23  E-value: 7.36e-10
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 17553810    533 FSKCQYPaRCADQFANGVCNQECNNEECLYDGLDCQ 568
Cdd:pfam00066    1 WPNCPYP-YCWDKFGNGVCDEECNNAECLWDGGDCS 35
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
914-1032 4.64e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 59.20  E-value: 4.64e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810  914 VNQVDsKYRRRVLHWLAANvrGKPEdvitteAIRCL-KAGADVNARDCDENTALMLAVRAHRVRLSVVLLREGANPTIFN 992
Cdd:COG0666  179 VNARD-NDGETPLHLAAEN--GHLE------IVKLLlEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKD 249

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 17553810  993 NSERSALHEAVVNKDLRILRHLLTDKRLLKEIDELDRNGM 1032
Cdd:COG0666  250 KDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 939-1119 9.56e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 59.23  E-value: 9.56e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810   939 DVITTE----AIRCLKAGADVNARDCDENTALMLAVRAHRVRLSVVLLREGANPTIFNNSERSALHEAVVNKDLRILRHL 1014
Cdd:PHA02875    8 DAILFGeldiARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEEL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810  1015 LTDKRLLKEIdeLDRNGMTALMLVARelgKHQVEMAELLLSKGAKLDYDGAARKdsnkykgrTALHYAAMHDNEEMVIML 1094
Cdd:PHA02875   88 LDLGKFADDV--FYKDGMTPLHLATI---LKKLDIMKLLIARGADPDIPNTDKF--------SPLHLAVMMGDIKGIELL 154

                         170       180
                  ....*....|....*....|....*
gi 17553810  1095 VRRSSNKDKQDEDGRTPIMLAAKEG 1119
Cdd:PHA02875  155 IDHKACLDIEDCCGCTPLIIAMAKG 179
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 530-567 1.11e-08

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 51.94  E-value: 1.11e-08
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 17553810     530 QRPFSKCQYpARCADQFANGVCNQECNNEECLYDGLDC 567
Cdd:smart00004    2 QDPWSRCED-AQCWDKFGDGVCDEECNNAECLWDGGDC 38
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 909-1130 1.14e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 58.91  E-value: 1.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810   909 ITNESVNqVDSKYRRRVLHWLAanVRGKPEDVItteaIRCLKAGADVNARDCDENTALMLAVRA-----HRVRLSVVLLR 983
Cdd:PHA03100   22 IMEDDLN-DYSYKKPVLPLYLA--KEARNIDVV----KILLDNGADINSSTKNNSTPLHYLSNIkynltDVKEIVKLLLE 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810   984 EGANPTIFNNSERSALHEAVVNK--DLRILRhLLTDKRllKEIDELDRNGMTALMLVArELGKHQVEMAELLLSKGAKLD 1061
Cdd:PHA03100   95 YGANVNAPDNNGITPLLYAISKKsnSYSIVE-YLLDNG--ANVNIKNSDGENLLHLYL-ESNKIDLKILKLLIDKGVDIN 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810  1062 ydgaaRKDSNKY-------------KGRTALHYAAMHDNEEMVIMLVRRSSNKDKQDEDGRTPIMLAAKEgCEKTVQYLA 1128
Cdd:PHA03100  171 -----AKNRVNYllsygvpinikdvYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILN-NNKEIFKLL 244


                  ..
gi 17553810  1129 LN 1130
Cdd:PHA03100  245 LN 246
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 489-526 1.39e-08

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 51.56  E-value: 1.39e-08
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 17553810     489 ETVIRDLCEQRKCMDLASNGICNPECNLEECNFDGGDC 526
Cdd:smart00004    1 PQDPWSRCEDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 961-1100 2.87e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 57.69  E-value: 2.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810   961 DENTALMLAVRAHRVRLSVVLLREGANPTIFNNSERSALHEAVVNKDLRILRhLLTDKRLLKEIDelDRNGMTALMLVar 1040
Cdd:PHA02875  101 DGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIE-LLIDHKACLDIE--DCCGCTPLIIA-- 175

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810  1041 eLGKHQVEMAELLLSKGAKLDYDGaarkdsnKYKGRTALHYAAMHDNEEMVIMLVRRSSN 1100
Cdd:PHA02875  176 -MAKGDIAICKMLLDSGANIDYFG-------KNGCVAALCYAIENNKIDIVRLFIKRGAD 227
PHA03095 PHA03095
ankyrin-like protein; Provisional
 913-1164 3.16e-08

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 57.73  E-value: 3.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810   913 SVNQVDSkYRRRVLHWLAANVRGKPEDVItteaiRCL-KAGADVNARDCDENTALMLAVR-AHRVRLSVVLLREGANPTI 990
Cdd:PHA03095   39 DVNFRGE-YGKTPLHLYLHYSSEKVKDIV-----RLLlEAGADVNAPERCGFTPLHLYLYnATTLDVIKLLIKAGADVNA 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810   991 FNNSERSALHE--AVVNKDLRILRHLLtdkRLLKEIDELDRNGMTALmlvARELGKHQ--VEMAELLLSKGAKLdydgaA 1066
Cdd:PHA03095  113 KDKVGRTPLHVylSGFNINPKVIRLLL---RKGADVNALDLYGMTPL---AVLLKSRNanVELLRLLIDAGADV-----Y 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810  1067 RKDSNkykGRTALHYAA--MHDNEEMVIMLVRRSSNKDKQDEDGRTPIMLAAKEGCEKT--VQYLALNDASLGIVDSMDM 1142
Cdd:PHA03095  182 AVDDR---FRSLLHHHLqsFKPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRslVLPLLIAGISINARNRYGQ 258

                         250       260
                  ....*....|....*....|..
gi 17553810  1143 TAAQVaeASYHHELAAFLRQVA 1164
Cdd:PHA03095  259 TPLHY--AAVFNNPRACRRLIA 278
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 232-269 4.41e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.33  E-value: 4.41e-08
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 17553810  232 DKNECLIEETCVNNSTCFNLHGDFTCTCKPGYAGKYCE 269
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 496-527 1.30e-07

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 48.68  E-value: 1.30e-07
                           10        20        30
                   ....*....|....*....|....*....|..
gi 17553810    496 CEQRKCMDLASNGICNPECNLEECNFDGGDCS 527
Cdd:pfam00066    4 CPYPYCWDKFGNGVCDEECNNAECLWDGGDCS 35
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1023-1160 2.09e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 54.19  E-value: 2.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810 1023 EIDELDRNGMTALMLVARELGKHQVEMAELLLSKGAKLDYDGAARKDSNKYKGRTALHYAAMHDNEEMVIMLVRRSSNKD 1102
Cdd:COG0666    2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADIN 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 17553810 1103 KQDEDGRTPIMLAAKEGCEKTVQYLALNDASLGIVDSMDMTAAQVAEASYHHELAAFL 1160
Cdd:COG0666   82 AKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLL 139
EGF_CA smart00179
Calcium-binding EGF-like domain;
232-269 6.37e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.86  E-value: 6.37e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 17553810     232 DKNECLIEETCVNNSTCFNLHGDFTCTCKPGY-AGKYCE 269
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
Ank_4 pfam13637
Ankyrin repeats (many copies);
1075-1127 1.63e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 46.11  E-value: 1.63e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 17553810   1075 GRTALHYAAMHDNEEMVIMLVRRSSNKDKQDEDGRTPIMLAAKEGCEKTVQYL 1127
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 949-1143 1.80e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 52.37  E-value: 1.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810   949 LKAGADVNARDCDENTALMLAVRAHRVRLSVVLLREGANPTIFNNSERSALHEAVVNKDLRILRHLLTDKrllkeiDELD 1028
Cdd:PHA02876  165 LEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNR------SNIN 238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810  1029 RNGMTALMLVARElgkhQVEMAELLlskgakldYDGAARKDSNKYKGRTALHYAAMHDN-EEMVIMLVRRSSNKDKQDED 1107
Cdd:PHA02876  239 KNDLSLLKAIRNE----DLETSLLL--------YDAGFSVNSIDDCKNTPLHHASQAPSlSRLVPKLLERGADVNAKNIK 306

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 17553810  1108 GRTPIMLAAKEGCE-KTVQYLALNDASLGIVDSMDMT 1143
Cdd:PHA02876  307 GETPLYLMAKNGYDtENIRTLIMLGADVNAADRLYIT 343
Ank_2 pfam12796
Ankyrin repeats (3 copies);
949-1015 8.01e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 45.49  E-value: 8.01e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17553810    949 LKAGADVNARDCDENTALMLAVRAHRVRLsVVLLREGANPTIFNNsERSALHEAVVNKDLRILRHLL 1015
Cdd:pfam12796   17 LENGADANLQDKNGRTALHLAAKNGHLEI-VKLLLEHADVNLKDN-GRTALHYAARSGHLEIVKLLL 81
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 955-1166 8.03e-06

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 50.46  E-value: 8.03e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810    955 VNARDCDENTALMLAVRAHRVRLSVVLLREGANPTIFNNS-----ERSALHEAVV---NKDLRILrhlltdkrlLKEIDE 1026
Cdd:TIGR00870    7 VPAEESPLSDEEKAFLPAAERGDLASVYRDLEEPKKLNINcpdrlGRSALFVAAIeneNLELTEL---------LLNLSC 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810   1027 LDRNGMTALMLVARELgKHQVEMAELLLSKGAKLDYDGA---ARKDSNKYKGRTALHYAAMHDNEEMVIMLVRRSSN--- 1100
Cdd:TIGR00870   78 RGAVGDTLLHAISLEY-VDAVEAILLHLLAAFRKSGPLElanDQYTSEFTPGITALHLAAHRQNYEIVKLLLERGASvpa 156

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17553810   1101 -------KDKQDED----GRTPIMLAAKEGCEKTVQYLALNDASLGIVDSMDMTA--AQVAEASYHHELAAFLRQVANE 1166
Cdd:TIGR00870  157 racgdffVKSQGVDsfyhGESPLNAAACLGSPSIVALLSEDPADILTADSLGNTLlhLLVMENEFKAEYEELSCQMYNF 235
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 369-406 1.12e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 1.12e-05
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 17553810  369 DIQSCK-YNPCVNNATCIDLKNSgYSCHCPLGFYGLNCE 406
Cdd:cd00054    1 DIDECAsGNPCQNGGTCVNTVGS-YRCSCPPGYTGRNCE 38
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 573-608 1.21e-05

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 43.29  E-value: 1.21e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 17553810    573 RCPAHirkHCIERRGDGVCNLECSFIGCGFDGGDCN 608
Cdd:pfam00066    3 NCPYP---YCWDKFGNGVCDEECNNAECLWDGGDCS 35
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 949-1151 2.19e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 48.72  E-value: 2.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810   949 LKAGADVNARDCDENTALMLAVRAHRVRLSVVLLREGANPTIFNnsERSALHEAVVNKDLRILRHLLTDKRL------LK 1022
Cdd:PHA02878   57 LTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSINKCSVFY--TLVAIKDAFNNRNVEIFKIILTNRYKniqtidLV 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810  1023 EIDELDRNGMTalmlvarelgkhQVEMAELLLSKGAKLDydgaaRKDSNKykGRTALHYAAMHDNEEMVIMLVRRSSNKD 1102
Cdd:PHA02878  135 YIDKKSKDDII------------EAEITKLLLSYGADIN-----MKDRHK--GNTALHYATENKDQRLTELLLSYGANVN 195

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 17553810  1103 KQDEDGRTPIMLAAKEGCEKTVQYLALNDASLGIVDSMDMTAAQVAEAS 1151
Cdd:PHA02878  196 IPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGY 244
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 949-1055 2.91e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 48.12  E-value: 2.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810   949 LKAGADVNARDCDENTALMLAVraHRVRLSVV--LLREGANPTIFNNSERSALHEAVVNKDLRILRHLLTDKR------- 1019
Cdd:PHA03100  179 LSYGVPINIKDVYGFTPLHYAV--YNNNPEFVkyLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPsiktiie 256

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 17553810  1020 --LLKEIDELDRNGMTALMlvarelgKHQVEMAELLLS 1055
Cdd:PHA03100  257 tlLYFKDKDLNTITKIKML-------KKSIMYMFLLDP 287
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 567-607 4.43e-05

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 41.93  E-value: 4.43e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 17553810     567 CQSELFRCPAhirKHCIERRGDGVCNLECSFIGCGFDGGDC 607
Cdd:smart00004    1 PQDPWSRCED---AQCWDKFGDGVCDEECNNAECLWDGGDC 38
Ank_4 pfam13637
Ankyrin repeats (many copies);
1032-1095 4.92e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 42.26  E-value: 4.92e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17553810   1032 MTALMLVARELGKhqVEMAELLLSKGAKLDydgaaRKDSNkykGRTALHYAAMHDNEEMVIMLV 1095
Cdd:pfam13637    1 ELTALHAAAASGH--LELLRLLLEKGADIN-----AVDGN---GETALHFAASNGNVEVLKLLL 54
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 894-1115 9.50e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 46.98  E-value: 9.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810   894 PLHVQAAGPdaitapitneSVNQVDSKYRRRVLHWLAANVRGK------PEDVITTEAIRCL-KAGADVNARDCDENTAL 966
Cdd:PHA02876  276 PLHHASQAP----------SLSRLVPKLLERGADVNAKNIKGEtplylmAKNGYDTENIRTLiMLGADVNAADRLYITPL 345

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810   967 MLAVRAHRVRLSVVLLRE-GANPTIFNNSERSALHEAVVNKDLRILRHLLTDKrllKEIDELDRNGMTALMLVAreLGKH 1045
Cdd:PHA02876  346 HQASTLDRNKDIVITLLElGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYG---ADIEALSQKIGTALHFAL--CGTN 420

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17553810  1046 QVEMAELLLSKGAKLDydgaarkDSNKYKGrTALHYAAMHDNEEMVI-MLVRRSSNKDKQDEDGRTPIMLA 1115
Cdd:PHA02876  421 PYMSVKTLIDRGANVN-------SKNKDLS-TPLHYACKKNCKLDVIeMLLDNGADVNAINIQNQYPLLIA 483
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 1074-1103 1.07e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 40.26  E-value: 1.07e-04
                            10        20        30
                    ....*....|....*....|....*....|
gi 17553810    1074 KGRTALHYAAMHDNEEMVIMLVRRSSNKDK 1103
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 949-1117 1.10e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 46.11  E-value: 1.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810   949 LKAGADVNARDCDENTALMLAVRAHRVRLSVVLLREGANPTIFNNSERSALHEAVVNKDLRILRHLLTDKrllKEIDELD 1028
Cdd:PHA02874  144 FEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHG---NHIMNKC 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810  1029 RNGMTALMLVArelgKHQVEMAELLLSKGAKLDYDgaarkdsnkYKGRTALHYAAMHD-NEEMVIMLVRRSSNKDKQDED 1107
Cdd:PHA02874  221 KNGFTPLHNAI----IHNRSAIELLINNASINDQD---------IDGSTPLHHAINPPcDIDIIDILLYHKADISIKDNK 287

                         170
                  ....*....|
gi 17553810  1108 GRTPIMLAAK 1117
Cdd:PHA02874  288 GENPIDTAFK 297
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 949-1139 1.10e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 46.11  E-value: 1.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810   949 LKAGADVNARDCDENTALMLAVRAHRVRLSVVLLREGANPTIFNNSERSALHEAVVNKDLRILRHLLTDKRLLkeiDELD 1028
Cdd:PHA02874  111 LDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYA---NVKD 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810  1029 RNGMTALMLVArELGKHQVemAELLLSKGAKLdydgaarkdSNKYK-GRTALHYAAMHdNEEMVIMLVRRSSNKDkQDED 1107
Cdd:PHA02874  188 NNGESPLHNAA-EYGDYAC--IKLLIDHGNHI---------MNKCKnGFTPLHNAIIH-NRSAIELLINNASIND-QDID 253

                         170       180       190
                  ....*....|....*....|....*....|...
gi 17553810  1108 GRTPIMLAAKEGCEK-TVQYLALNDASLGIVDS 1139
Cdd:PHA02874  254 GSTPLHHAINPPCDIdIIDILLYHKADISIKDN 286
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1047-1127 1.22e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 46.43  E-value: 1.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810  1047 VEMAELLLSK---GAKLDYDGAARKDSNKYKGRTALHYAAMHDNEEMVIMLVRRSSNKDKQDEDGRTPIMLAAKEGCEKT 1123
Cdd:PTZ00322   84 VELCQLAASGdavGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREV 163


                  ....
gi 17553810  1124 VQYL 1127
Cdd:PTZ00322  164 VQLL 167
EGF_CA smart00179
Calcium-binding EGF-like domain;
369-406 1.99e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 1.99e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 17553810     369 DIQSCK-YNPCVNNATCIDLKNSgYSCHCPLGFY-GLNCE 406
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGS-YRCECPPGYTdGRNCE 39
Ank_4 pfam13637
Ankyrin repeats (many copies);
995-1054 3.41e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.57  E-value: 3.41e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810    995 ERSALHEAVVNKDLRILRhLLTDKRLlkEIDELDRNGMTALMLVARelgKHQVEMAELLL 1054
Cdd:pfam13637    1 ELTALHAAAASGHLELLR-LLLEKGA--DINAVDGNGETALHFAAS---NGNVEVLKLLL 54
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 918-1061 5.50e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 44.47  E-value: 5.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810   918 DSKyRRRVLHWLAANVRgkpEDVITTeairCLKAGADVNARDCDENTALMLAVRAHRVRLSVVL--LREGANPTIFNNse 995
Cdd:PLN03192  555 DSK-GRTPLHIAASKGY---EDCVLV----LLKHACNVHIRDANGNTALWNAISAKHHKIFRILyhFASISDPHAAGD-- 624

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17553810   996 rsALHEAVVNKDLRILRHLLtdkRLLKEIDELDRNGMTALMLVARElgkHQVEMAELLLSKGAKLD 1061
Cdd:PLN03192  625 --LLCTAAKRNDLTAMKELL---KQGLNVDSEDHQGATALQVAMAE---DHVDMVRLLIMNGADVD 682
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 235-269 5.64e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 38.61  E-value: 5.64e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 17553810  235 ECLIEETCVNNSTCFNLHGDFTCTCKPGYAG-KYCE 269
Cdd:cd00053    1 ECAASNPCSNGGTCVNTPGSYRCVCPPGYTGdRSCE 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 155-190 1.03e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.03e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 17553810  155 IDHCAQ-NECAEGSTCVNSVYNYYCDCPIGKSGRYCE 190
Cdd:cd00054    2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 451-479 1.64e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.64e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 17553810  451 SRHPCKNGGVCKNTG---YCECQYGYTGPTCE 479
Cdd:cd00054    7 SGNPCQNGGTCVNTVgsyRCSCPPGYTGRNCE 38
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 899-1005 1.83e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 42.58  E-value: 1.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810   899 AAGPDAITAPitNESVNQVdskyrrrVLHWLAANVRGKPEDVITTEAIRCLKAGADVNARDCDENTALMLAVRAHRVRLS 978
Cdd:PTZ00322   61 DATPDHNLTT--EEVIDPV-------VAHMLTVELCQLAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVV 131

                          90       100
                  ....*....|....*....|....*..
gi 17553810   979 VVLLREGANPTIFNNSERSALHEAVVN 1005
Cdd:PTZ00322  132 RVLLEFGADPTLLDKDGKTPLELAEEN 158
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1074-1106 1.89e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 36.88  E-value: 1.89e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 17553810   1074 KGRTALHYAA-MHDNEEMVIMLVRRSSNKDKQDE 1106
Cdd:pfam00023    1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 118-152 1.94e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.94e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 17553810  118 VNPCDS-DPC-NNGLCYPFYGGFQCICNNGYGGSYCE 152
Cdd:cd00054    2 IDECASgNPCqNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Ank_5 pfam13857
Ankyrin repeats (many copies);
953-1002 1.95e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 37.71  E-value: 1.95e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 17553810    953 ADVNARDCDENTALMLAVRAHRVRLSVVLLREGANPTIFNNSERSALHEA 1002
Cdd:pfam13857    7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 949-1058 2.16e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 41.90  E-value: 2.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810   949 LKAGADVNARDCDENTALMLAVRAHRVRLSVVLLREGANPTIFNNSERSALHEAVVNKDLRILRHLLTDKrllKEIDELD 1028
Cdd:PHA02875  122 IARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSG---ANIDYFG 198

                          90       100       110
                  ....*....|....*....|....*....|
gi 17553810  1029 RNGMTALMLVARElgKHQVEMAELLLSKGA 1058
Cdd:PHA02875  199 KNGCVAALCYAIE--NNKIDIVRLFIKRGA 226
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1112-1171 2.73e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 38.17  E-value: 2.73e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810   1112 IMLAAKEGCEKTVQYLALNDASLGIVDSMDMTAAQVAEASYHHELAAFLRQVANERHRND 1171
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDN 60
TRPV1 cd22196
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 ...
 995-1166 4.09e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 (TRPV1), a capsaicin (vanilloid) receptor, is the founding member of the vanilloid TRP subfamily (TRPV). In humans, it is expressed in the brain, kidney, pancreas, testis, uterus, spleen, stomach, small intestine, lung and liver. TRPV1 has been implicated to have function in thermo-sensation (heat), autonomic thermoregulation, nociception, food intake regulation, and multiple functions in the gastrointestinal (GI) tract. The receptor has also been involved in growth cone guidance, long-term depression, endocannabinoid signaling and osmosensing in the central nervous system. TRPV1 is up regulated in several human pathological conditions including vulvodynia, GI inflammation, Crohn's disease and ulcerative colitis. TRPV1 knock-out mice exhibit impaired sensation to thermal-mechanical acute pain. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411980 [Multi-domain]  Cd Length: 649  Bit Score: 41.33  E-value: 4.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810  995 ERSALHEAVVNKDLRILRHLL-----TDKRLLKEIDELDRNGMTALMLVARELGKHQVEMAELLLSKGAKLDY----DGA 1065
Cdd:cd22196    6 DRRRIFDAVAKGDCKELDGLLeylmrTKKRLTDSEFKDPETGKTCLLKAMLNLHNGQNDTISLLLDIAEKTGNlkefVNA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17553810 1066 ARKDsNKYKGRTALHYAAMHDNEEMVIMLVRRSSN----------KDKQDED----GRTPIMLAAKEGCEKTVQYLALND 1131
Cdd:cd22196   86 AYTD-SYYKGQTALHIAIERRNMHLVELLVQNGADvharasgeffKKKKGGPgfyfGELPLSLAACTNQLDIVKFLLENP 164

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 17553810 1132 ---ASLGIVDSMDMTA--AQVAEASYHHELAAFLRQVANE 1166
Cdd:cd22196  165 hspADISARDSMGNTVlhALVEVADNTPENTKFVTKMYNE 204
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1074-1100 7.25e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 35.31  E-value: 7.25e-03
                           10        20
                   ....*....|....*....|....*..
gi 17553810   1074 KGRTALHYAAMHDNEEMVIMLVRRSSN 1100
Cdd:pfam13606    1 DGNTPLHLAARNGRLEIVKLLLENGAD 27
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 373-404 7.32e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 7.32e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 17553810    373 CKYNPCVNNATCIDLKNsGYSCHCPLGFYGLN 404
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPG-GYTCICPEGYTGKR 31
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1030-1061 8.29e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 35.34  E-value: 8.29e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 17553810   1030 NGMTALMLVARELGkhQVEMAELLLSKGAKLD 1061
Cdd:pfam00023    1 DGNTPLHLAAGRRG--NLEIVKLLLSKGADVN 30
Ank_4 pfam13637
Ankyrin repeats (many copies);
1108-1160 9.25e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 35.71  E-value: 9.25e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 17553810   1108 GRTPIMLAAKEGCEKTVQYLALNDASLGIVDSMDMTAAQVAEASYHHELAAFL 1160
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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