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Conserved domains on  [gi|32564663|ref|NP_498960|]
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Putative transporter svop-1 [Caenorhabditis elegans]

Protein Classification

synaptic vesicle 2-related protein( domain architecture ID 13024567)

synaptic vesicle 2-related protein (SVOP) is a synaptic vesicle protein that is similar to transmembrane glycoprotein SV2

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
86-508 0e+00

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 595.25  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  86 SILTGMAWMADAMEMMLLSLISPALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVI 165
Cdd:cd17441   1 SILTGLAWMADAMEMMILSILAPQLHCEWRLPSWQVALLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGIL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 166 SGMSPHFYVLLFFRGLTGFGIGGVPQSVTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFGWRALMFLSSL 245
Cdd:cd17441  81 SAFAPIYSWILVLRGLVGFGIGGVPQSVTLYAEFLPMKSRAKCILLIEVFWALGTVFEVLLAVFVMPTLGWRWLLILSAL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 246 PLGIFAVASFWLPESARFdmasghperaletlqaaarmnrvqlptgrlvsstkagsesrgdianllspdlrKTTILLWCI 325
Cdd:cd17441 161 PLLIFAVLCFWLPESARY-----------------------------------------------------WTTILLWFI 187
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 326 WAITAFSYYGMVLFTTVLFQSHDECHGGL--FSNGTQMEVCQPLTRSDYFDLLSTTLAEFPGLIITVLIIEWFGRKKTMA 403
Cdd:cd17441 188 WFSNAFSYYGLVLLTTELFQAGDVCSGSSgkKVEGKCSLECEYLTTSDYMDLLWTTLSEFPGLLVTLWIIDRFGRKKTMA 267
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 404 LEYAVFAIFTFLLYFCLDRFTVTVLIFVARAFISGAFQCAYVYTPEVYPTTLRAVGLGTCSAMARIGAIVTPFIAQVASE 483
Cdd:cd17441 268 LCFFVFSFCTLLLFSCVGRFSLTVLLFIARAFISGGFQAAYVYTPEVYPTATRALGLGTCSGMARVGALITPFIAQVMLE 347
                       410       420
                ....*....|....*....|....*
gi 32564663 484 KSLSLPIGIYGTAAILGLIASLSLP 508
Cdd:cd17441 348 SSVYLTLSVYSGCCLLAAIASCFLP 372
 
Name Accession Description Interval E-value
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
86-508 0e+00

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 595.25  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  86 SILTGMAWMADAMEMMLLSLISPALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVI 165
Cdd:cd17441   1 SILTGLAWMADAMEMMILSILAPQLHCEWRLPSWQVALLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGIL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 166 SGMSPHFYVLLFFRGLTGFGIGGVPQSVTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFGWRALMFLSSL 245
Cdd:cd17441  81 SAFAPIYSWILVLRGLVGFGIGGVPQSVTLYAEFLPMKSRAKCILLIEVFWALGTVFEVLLAVFVMPTLGWRWLLILSAL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 246 PLGIFAVASFWLPESARFdmasghperaletlqaaarmnrvqlptgrlvsstkagsesrgdianllspdlrKTTILLWCI 325
Cdd:cd17441 161 PLLIFAVLCFWLPESARY-----------------------------------------------------WTTILLWFI 187
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 326 WAITAFSYYGMVLFTTVLFQSHDECHGGL--FSNGTQMEVCQPLTRSDYFDLLSTTLAEFPGLIITVLIIEWFGRKKTMA 403
Cdd:cd17441 188 WFSNAFSYYGLVLLTTELFQAGDVCSGSSgkKVEGKCSLECEYLTTSDYMDLLWTTLSEFPGLLVTLWIIDRFGRKKTMA 267
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 404 LEYAVFAIFTFLLYFCLDRFTVTVLIFVARAFISGAFQCAYVYTPEVYPTTLRAVGLGTCSAMARIGAIVTPFIAQVASE 483
Cdd:cd17441 268 LCFFVFSFCTLLLFSCVGRFSLTVLLFIARAFISGGFQAAYVYTPEVYPTATRALGLGTCSGMARVGALITPFIAQVMLE 347
                       410       420
                ....*....|....*....|....*
gi 32564663 484 KSLSLPIGIYGTAAILGLIASLSLP 508
Cdd:cd17441 348 SSVYLTLSVYSGCCLLAAIASCFLP 372
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
16-514 5.99e-172

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 494.92  E-value: 5.99e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663    16 LTEAYVDLTAKQLIKEIRHVGDDFaVRYSNLDDRTELG-----EPTDQRSPD----SEKTFTVDEAVEALGFGRFQLKLS 86
Cdd:TIGR00898  12 LLLALPIALLAFHFVLIVFLGATP-EHHCRLPDAANLSsrcelNLTLPRLPDgrpeSCLRFMVDQWANPSLLGCEPLKLS 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663    87 ILtGMAWMADAMEMMLLSL--ISPALACEWGI---SSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACI 161
Cdd:TIGR00898  91 DL-GLAATEPCLDGWEYSYdtFSSTIVTEWDLvceDAWKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAV 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   162 MGVISGMSPHFYVLLFFRGLTGFGIGG-VPQSVTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMEsfgWRALM 240
Cdd:TIGR00898 170 SGVLTAFSPNYTVFLVFRLLVGMGIGGiWVQAVVLNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLVAYFIPD---WRWLQ 246
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   241 FLSSLPLGIFAVASFWLPESARFDMASGHPERALETLQAAARMNRVQLPTGRLVSS-TKAGSESR---GDIANLLSPDLR 316
Cdd:TIGR00898 247 LAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILQRIAKINGKKLPAEVLSLSlEKDLSSSKkqySFLDLFRTPNLR 326
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   317 KTTILLWCIWAITAFSYYGMVLFTTVLFQshdechgglfsngtqmevcqpltrSDYFDLLSTTLAEFPGLIITVLIIEWF 396
Cdd:TIGR00898 327 KTTLCLMMLWFTTAFSYYGLVLDLGNLGG------------------------NIYLDLFISGLVELPAKLITLLLIDRL 382
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   397 GRKKTMALEYAVFAIFTFLLYFCLDR--FTVTVLIFVARAFISGAFQCAYVYTPEVYPTTLRAVGLGTCSAMARIGAIVT 474
Cdd:TIGR00898 383 GRRYTMAASLLLAGVALLLLLFVPVDlyFLRTALAVLGKFGITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARVGSIIS 462
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|
gi 32564663   475 PFIAQvASEKSLSLPIGIYGTAAILGLIASLSLPIETKGR 514
Cdd:TIGR00898 463 PFLVY-LGEKWLFLPLVLFGGLALLAGILTLFLPETKGVP 501
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
79-512 1.01e-33

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 131.15  E-value: 1.01e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  79 GRFQLKLSILTGMAWMADAMEMMLLSLISPALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLV 158
Cdd:COG2271   5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 159 ACIMGVISGMSPHFYVLLFFRGLTGFGIGGV-PQSVTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFGWR 237
Cdd:COG2271  85 WGLATLLFGFATSFWQLLLLRFLLGLGEAGFfPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWR 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 238 ALMFLSSLPLGIFAVASFWlpesarfdmasghperaletlqaaarmnrvqlptgrlvsstkagsesrgdianllspdlrk 317
Cdd:COG2271 165 AAFLILGLPGLLLALLRFW------------------------------------------------------------- 183
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 318 ttiLLWCIWAITAFSYYGMVLFTTVLFQSHdecHGglfsngtqmevcQPLTRSDYFdLLSTTLAEFPGLIITVLIIEWFG 397
Cdd:COG2271 184 ---LLALAYFLVYFALYGFLTWLPTYLVEV---RG------------LSLAQAGLL-LSLPFLAGIVGSLLGGWLSDRLG 244
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 398 R--KKTMALEYAVFAIFTFLLYFCLDRFTVTVLIFVARAFISGAFQCAYVYTPEVYPTTLRAVGLGTCSAMARIGAIVTP 475
Cdd:COG2271 245 RrrKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGP 324
                       410       420       430
                ....*....|....*....|....*....|....*...
gi 32564663 476 F-IAQVASEKSLSLPIGIYGTAAILGLIASLSLPIETK 512
Cdd:COG2271 325 LlVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
Sugar_tr pfam00083
Sugar (and other) transporter;
117-514 1.08e-30

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 124.31  E-value: 1.08e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   117 SSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSP---HFYVLLFFRGLTGFGIGGVPQSV 193
Cdd:pfam00083  44 LSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKgkwSVYQLIVGRVLVGIGVGGASVLA 123
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   194 TLY-AEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFV---MESFGWRALMFLSSLPLGIFAVASFWLPESARFDMASGH 269
Cdd:pfam00083 124 PMYiSEIAPKKLRGALGSLYQLAITFGILLAYIFGLGLnktSNSDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGR 203
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   270 PERALETLQaaaRMNRVQLPTGRLV----SSTKAGSESRGDIANLLSPDLRKTTILLWCIWA-------ITAFSYYGMVL 338
Cdd:pfam00083 204 LEEAREVLA---KLRGVPDVDRELDeikdSLEAGQEAEKASWKELFSTKTRRQRLLIGVMLQifqqltgINAIFYYSTTI 280
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   339 FTTVLFQshdechGGLFSNGTQMEVcqpltrsdyfDLLSTtlaefpglIITVLIIEWFGRKKTMALEYAVFAIFTFLL-- 416
Cdd:pfam00083 281 FENLGLS------DSFLVTIIVGVV----------NFVFT--------FIAIFLVDRFGRRPLLLLGAAGMAICFVILgi 336
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   417 --YFCLDR-------FTVTVLIFVArAFISGAFQCAYVYTPEVYPTTLRAVGLGTCSAMARIGAIVTPFIAQVASEKSLS 487
Cdd:pfam00083 337 vaLLGVSKsdwagivAIVFIALFIA-FFAMGWGPVPWVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDAIGL 415
                         410       420
                  ....*....|....*....|....*....
gi 32564663   488 LPIGIY--GTAAILGLIASLSLPiETKGR 514
Cdd:pfam00083 416 GYTFFIfaGLLVLFIIFVFFFVP-ETKGR 443
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
108-478 1.27e-14

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 75.77  E-value: 1.27e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  108 PALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLLFFRGLTGFGIG 187
Cdd:PRK11551  39 PRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLG 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  188 G-VPQSVTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFGWRALMFLSSL-PLGIFAVASFWLPESARFDM 265
Cdd:PRK11551 119 GaLPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGGVgPLLLVPLLMRWLPESRAFAQ 198
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  266 ASGHPERALETLQAaarmnrvqlptgrlvsstkagsesrgdianLLSPDLRKTTILLWciwaitaFSYygmvLFT-TVLF 344
Cdd:PRK11551 199 AAGAGKQRAPVLRA------------------------------LFGEGRATATLLLW-------ISY----FFTlIVLY 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  345 QshdechggLFSNGTQMEVCQPLTRSD------YFDLlsttlaefpGLIITVLIIEW----FGRKKTMALEYAvfAIFTF 414
Cdd:PRK11551 238 F--------LLNWLPSLLVGQGLSRSQaglvqiAFNI---------GGALGSLLIGAlmdrLRPRRVVLLIYA--GILAS 298
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 32564663  415 LLYFCLDRFTVTVLI--FVARAFISGAFQCAYVYTPEVYPTTLRAVGLGTCSAMARIGAIVTPFIA 478
Cdd:PRK11551 299 LAALAAAPSFAGMLLagFAAGLFVVGGQSVLYALAPLFYPTQVRGTGVGAAVAVGRLGSMAGPLLA 364
 
Name Accession Description Interval E-value
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
86-508 0e+00

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 595.25  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  86 SILTGMAWMADAMEMMLLSLISPALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVI 165
Cdd:cd17441   1 SILTGLAWMADAMEMMILSILAPQLHCEWRLPSWQVALLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGIL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 166 SGMSPHFYVLLFFRGLTGFGIGGVPQSVTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFGWRALMFLSSL 245
Cdd:cd17441  81 SAFAPIYSWILVLRGLVGFGIGGVPQSVTLYAEFLPMKSRAKCILLIEVFWALGTVFEVLLAVFVMPTLGWRWLLILSAL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 246 PLGIFAVASFWLPESARFdmasghperaletlqaaarmnrvqlptgrlvsstkagsesrgdianllspdlrKTTILLWCI 325
Cdd:cd17441 161 PLLIFAVLCFWLPESARY-----------------------------------------------------WTTILLWFI 187
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 326 WAITAFSYYGMVLFTTVLFQSHDECHGGL--FSNGTQMEVCQPLTRSDYFDLLSTTLAEFPGLIITVLIIEWFGRKKTMA 403
Cdd:cd17441 188 WFSNAFSYYGLVLLTTELFQAGDVCSGSSgkKVEGKCSLECEYLTTSDYMDLLWTTLSEFPGLLVTLWIIDRFGRKKTMA 267
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 404 LEYAVFAIFTFLLYFCLDRFTVTVLIFVARAFISGAFQCAYVYTPEVYPTTLRAVGLGTCSAMARIGAIVTPFIAQVASE 483
Cdd:cd17441 268 LCFFVFSFCTLLLFSCVGRFSLTVLLFIARAFISGGFQAAYVYTPEVYPTATRALGLGTCSGMARVGALITPFIAQVMLE 347
                       410       420
                ....*....|....*....|....*
gi 32564663 484 KSLSLPIGIYGTAAILGLIASLSLP 508
Cdd:cd17441 348 SSVYLTLSVYSGCCLLAAIASCFLP 372
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
16-514 5.99e-172

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 494.92  E-value: 5.99e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663    16 LTEAYVDLTAKQLIKEIRHVGDDFaVRYSNLDDRTELG-----EPTDQRSPD----SEKTFTVDEAVEALGFGRFQLKLS 86
Cdd:TIGR00898  12 LLLALPIALLAFHFVLIVFLGATP-EHHCRLPDAANLSsrcelNLTLPRLPDgrpeSCLRFMVDQWANPSLLGCEPLKLS 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663    87 ILtGMAWMADAMEMMLLSL--ISPALACEWGI---SSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACI 161
Cdd:TIGR00898  91 DL-GLAATEPCLDGWEYSYdtFSSTIVTEWDLvceDAWKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAV 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   162 MGVISGMSPHFYVLLFFRGLTGFGIGG-VPQSVTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMEsfgWRALM 240
Cdd:TIGR00898 170 SGVLTAFSPNYTVFLVFRLLVGMGIGGiWVQAVVLNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLVAYFIPD---WRWLQ 246
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   241 FLSSLPLGIFAVASFWLPESARFDMASGHPERALETLQAAARMNRVQLPTGRLVSS-TKAGSESR---GDIANLLSPDLR 316
Cdd:TIGR00898 247 LAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILQRIAKINGKKLPAEVLSLSlEKDLSSSKkqySFLDLFRTPNLR 326
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   317 KTTILLWCIWAITAFSYYGMVLFTTVLFQshdechgglfsngtqmevcqpltrSDYFDLLSTTLAEFPGLIITVLIIEWF 396
Cdd:TIGR00898 327 KTTLCLMMLWFTTAFSYYGLVLDLGNLGG------------------------NIYLDLFISGLVELPAKLITLLLIDRL 382
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   397 GRKKTMALEYAVFAIFTFLLYFCLDR--FTVTVLIFVARAFISGAFQCAYVYTPEVYPTTLRAVGLGTCSAMARIGAIVT 474
Cdd:TIGR00898 383 GRRYTMAASLLLAGVALLLLLFVPVDlyFLRTALAVLGKFGITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARVGSIIS 462
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|
gi 32564663   475 PFIAQvASEKSLSLPIGIYGTAAILGLIASLSLPIETKGR 514
Cdd:TIGR00898 463 PFLVY-LGEKWLFLPLVLFGGLALLAGILTLFLPETKGVP 501
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
86-507 3.12e-120

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 358.00  E-value: 3.12e-120
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  86 SILTGMAWMADAMEMMLLSLISPALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVI 165
Cdd:cd17372   1 LAYAGMGWVAEAMEMMLLSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 166 SGMSPHFYVLLFFRGLTGFGIGGVPQSVTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFGWRALMFLSSL 245
Cdd:cd17372  81 SAFAPNYMWLIILRCLVGLGLGGGPQLASWYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLGWRWLLAFSSV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 246 PLGIFAVASFWLPesarfdmasghperaletlqaaarmnrvqlptgrlvsstkagsesrgdianllspdlrKTTILLWCI 325
Cdd:cd17372 161 PSSLLLVFYRWTP----------------------------------------------------------KTTLLLWVI 182
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 326 WAITAFSYYGMVLFTTVLFQSHDECHGGLFSNGTQMEV---CQPLTRSDYFDLLSTTLAEFPGLIITVLIIEWFGRKKTM 402
Cdd:cd17372 183 WFGNAFAYYGVVLLTTELNNSHNVCGSKSDSDSGESPTekqCRNSNDVDYRDVFIATFAEFPGLLISAAMIDRLGRKASM 262
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 403 ALEYAVFAIFTFLLYFCLDRFTVTVLIFVARAFISGAFQCAYVYTPEVYPTTLRAVGLGTCSAMARIGAIVTPFIAQVAS 482
Cdd:cd17372 263 ASMLFTCCIFLLLLLICQSPFILTVLLFGGRACISAAFTVVYIYTPEVYPTAVRALGVGTGSSVGRIGAILCPFIAQVLV 342
                       410       420
                ....*....|....*....|....*
gi 32564663 483 EKSLSLPIGIYGTAAILGLIASLSL 507
Cdd:cd17372 343 HGSQTIALLLFSVVCLVSAICVCLL 367
MFS_SVOPL cd17442
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ...
85-508 1.27e-68

Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341000 [Multi-domain]  Cd Length: 375  Bit Score: 225.07  E-value: 1.27e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  85 LSILTGMAWMADAMEMMLLSLISPALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGV 164
Cdd:cd17442   2 LFLIMGSTGVAEAMEIMLLAVVSPEIRCEWHLEDWQVALVTTMVFFGYMVFSILLGLLADRYGRWKILLLSFVWGAYFSL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 165 ISGMSPHFYVLLFFRGLTGFGIGGVPQSVTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFGWRALMFLSS 244
Cdd:cd17442  82 LTSFAPSYIWFVFLRCMVGCGVSGHSQGLIIKTEFLPTKYRGYMLPLSQIFWLAGSLLIIGLASVVIPTLGWRWLIRFAS 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 245 LPLGIFAVASFWLPesarfdmasghperaletlqaaarmnrvqlptgrlvsstkagsesrgdianllspdlrKTTILLWC 324
Cdd:cd17442 162 IPGIILIVVFKFIP----------------------------------------------------------RTTLQIWV 183
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 325 IWAITAFSYYGMVLFTTVLFQ--------SHDECHGGLFSNGTQMEVCQPLTRSDYFDLLSTTLAEFPGLIITVLIIEWF 396
Cdd:cd17442 184 IWLGISFAYYGVILASSELLErnllcgsdPSDEEAGIKHIESESPCYCHMFNPSDYQTMIISTLGEIALNPLNILGINFL 263
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 397 GRKKTMALEYAVFAIFTFLLYFCLDRFTVTVLIFVARAFISGAFQCAYVYTPEVYPTTLRAVGLGTCSAMARIGAIVTPF 476
Cdd:cd17442 264 GRRLSLVITMGLTAIFFLLLNICTSSAGLTIFLFMLRALVSANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPF 343
                       410       420       430
                ....*....|....*....|....*....|..
gi 32564663 477 IAQVASEKSLSLPIGIYGTAAILGLIASLSLP 508
Cdd:cd17442 344 ISQVLMSASVLGALCLFSSVCIVCAISAFTLP 375
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
87-505 4.79e-53

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 183.19  E-value: 4.79e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  87 ILTGMAWMADAMEMMLLSLISPALACE--WGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGV 164
Cdd:cd17316   2 LLAGLGWFFDAYDFFLIGFVAPVLAAEfsLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 165 ISGMSPHFYVLLFFRGLTGFGIGG-VPQSVTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVM----ESFGWRAL 239
Cdd:cd17316  82 LIGLLPTPILLLVLRFLQGIGIGGeYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIpllsGDWGWRIL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 240 MFLSslplGIFAVASFWlpesarfdmasghperaletlqaaarmnrvqlptgrlvsstkagsesrgdianllspdLRKTT 319
Cdd:cd17316 162 FLIG----ALPALLALL----------------------------------------------------------LRRRT 179
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 320 ILLWCIWAITAFSYYGMVLFTTVLFQShdechgGLFSNGTQMevcqpltrsdYFDLLSTTLAEFPGLIITVLIIEWFGRK 399
Cdd:cd17316 180 LLLILLWFFISFGYYGLTTFLPTYLQT------VLGLSPATS----------SLYLLLISLGALVGALIAGLLSDRIGRK 243
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 400 KTMALEYAVFAIFTFLLYFCLDR--FTVTVLIFVARAFISGAFQCAYVYTPEVYPTTLRAVGLGTCSAMARIGAIVTPFI 477
Cdd:cd17316 244 KTLVIGLILSGILALPLFYLLSGspTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPL 323
                       410       420       430
                ....*....|....*....|....*....|
gi 32564663 478 AQVASEKSLSLPIGIY--GTAAILGLIASL 505
Cdd:cd17316 324 IALLLASTGGTGVPALilALLAIVALIVAL 353
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
113-508 5.34e-45

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 161.21  E-value: 5.34e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 113 EWGI---SSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLLFFRGLTGFGIGGV 189
Cdd:cd17317  16 EWDLvcdRDWLVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGI 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 190 PQS-VTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMEsfgWRALMFLSSLPLGIFAVASFWLPesarfdmasg 268
Cdd:cd17317  96 FTVgFVLGMEIVGPKYRSFVGILFGLFWALGYMLLALLAYLIRD---WRWLQLAISLPGLLFLLLLWWLP---------- 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 269 hperaletlqaaarmnrvqlptgrlvsstkagsesrgdianllspdlrKTTILLWCIWAITAFSYYGMVLFTTVLfqshd 348
Cdd:cd17317 163 ------------------------------------------------RRTIIVGLIWFVTSLVYYGLSLNSSNL----- 189
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 349 echgglfsngtqmevcqplTRSDYFDLLSTTLAEFPGLIITVLIIEWFGRKKTMALEYAVFAIFTFLLYFCLDRFTVTVL 428
Cdd:cd17317 190 -------------------GGNLYLNFFLSGLVEIPAYFLALLLLDRLGRRWTLSGSLLLAGLACLVTALLPDDENTLAL 250
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 429 IF--VARAFISGAFQCAYVYTPEVYPTTLRAVGLGTCSAMARIGAIVTPFIAQVASEkSLSLPIGIYGTAAILGLIASLS 506
Cdd:cd17317 251 TLalVGKFAISAAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGAILAPFIVLLGKI-GPLLPLIIFGVLALLGGLLTLL 329

                ..
gi 32564663 507 LP 508
Cdd:cd17317 330 LP 331
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
80-478 1.86e-43

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 158.67  E-value: 1.86e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663    80 RFQLKLSILTGMAWMADAMEMMLLSLISPALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVA 159
Cdd:TIGR00895  13 RYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLF 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   160 CIMGVISGMSPHFYVLLFFRGLTGFGIGG-VPQSVTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFGWRA 238
Cdd:TIGR00895  93 SVFTLLCALATNVTQLLILRFLAGLGLGGlMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRS 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   239 LMFLSSL-PLGIFAVASFWLPESARFdMASGHPERALETLQAAARMNRVQLPTGRLVSSTKAGSEsRGDIANLLSPDLRK 317
Cdd:TIGR00895 173 LFYVGGIaPLLLLLLLMRFLPESIDF-LVSKRPETVRRIVNAIAPQMQAEAQSALPEQKSTQGTK-RSVFKALFQGKTAR 250
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   318 TTILLWCIWAITAFSYYGMVLFTTVLfqshdechgglfsngtQMEVCQPLTRSDYFDLLSTTLAEFPGLIITVLIIEwFG 397
Cdd:TIGR00895 251 ITVLLWLLYFMLLVGVYFLTNWLPKL----------------MVELGFSLSLAATGGALFNFGGVIGSIIFGWLADR-LG 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   398 RKKTMALeYAVFAIFTFLLYFCLDRFTVTV-LIFVARAFISGAFQCAYVYTPEVYPTTLRAVGLGTCSAMARIGAIVTPF 476
Cdd:TIGR00895 314 PRVTALL-LLLGAVFAVLVGSTLFSPTLLLlLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPI 392

                  ..
gi 32564663   477 IA 478
Cdd:TIGR00895 393 LA 394
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
92-508 5.31e-40

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 148.99  E-value: 5.31e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  92 AWMADAMEMMLLSLISPALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPH 171
Cdd:cd17371   7 GWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQN 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 172 FYVLLFFRGLTGFGIGG-VPQSVTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVM----ESFGWRALMFLSSLP 246
Cdd:cd17371  87 YWQLLILRALAGLGFGGeWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFpllpPEIAWRVLFLLGALP 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 247 LGIFAVASFWLPESARFdmasghperaletlqAAARMNRvqlptgrlvsstkAGSESRGDIANLLSPDLRKTTiLLWCIW 326
Cdd:cd17371 167 ALLVLFIRRFVKEPPQW---------------QAARAAR-------------RHFADRPSLRELFSPPLLRTT-LLASLL 217
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 327 AITA-FSYYG-MVLFTTVLFQSHDechgglfsngtqMEVcqpLTRSDYfdLLSTTLAEFPGLIITVLIIEWFGRKKTMAL 404
Cdd:cd17371 218 ATGAlGGYYGiTTWLPSYLTGERG------------LSF---EGSAGY--LVVTILGGFLGYLAGGFLADRIGRRNNFAL 280
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 405 EYAVFAIFTFLLYFCLDRFTVT-VLIFVARAFISGAFQCAYVYTPEVYPTTLRAVGLGTCSAMARIGAIVTPF-IAQVAS 482
Cdd:cd17371 281 FALGSAISILLYFFLPLSPTLIlILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFlVGFLAT 360
                       410       420
                ....*....|....*....|....*..
gi 32564663 483 EKSLSLPIGIYGTAA-ILGLIASLSLP 508
Cdd:cd17371 361 SGSLGTAIAVFAAVYyIAGLVLALLLP 387
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
31-517 4.03e-37

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 145.89  E-value: 4.03e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663    31 EIRHVGDDFAVRYSNLDDR--TELGEPTDQRSPDSEKTFTVDEAV-EALGFGRFQLKLSILTGMAWMADAMEMMLLSLIS 107
Cdd:TIGR01299 111 EIMADGAPKAGVRDELKDGegPPGGEGEAERRADEEELAQQYELIiQECGHGRFQWALFFVLGLALMADGVEVFVVGFVL 190
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   108 PALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLLFFRGLTGFGIG 187
Cdd:TIGR01299 191 PSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFLFCRLLSGFGIG 270
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   188 G-VPQSVTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFG-------------WRALMFLSSLPLGIFAVA 253
Cdd:TIGR01299 271 GaIPIVFSYFAEFLAQEKRGEHLSWLCMFWMIGGIYAAAMAWAIIPHYGwsfqmgsayqfhsWRVFVIVCAFPCVFAIGA 350
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   254 SFWLPESARFDM---------------------ASGHPERA-----LETLQAAARMNRVQLPTGR-----LVSSTKAGSE 302
Cdd:TIGR01299 351 LTFMPESPRFFLengkhdeawmilklihdtnmrAKGHPEKVfsvnhIKTIHQEDELIEIESDTGTwyqrcFVRALSEGGG 430
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   303 SRGDIANLLSPDLRKTTILLWCIWAITAFSYYGM-VLFTTVL--------------------------FQSHDECHGGL- 354
Cdd:TIGR01299 431 IWGNFLRCFNPEVREITIKLMGVWFTLSFGYYGLsVWFPDMIkhlqaddyaaltknfpgdkvahfsfnFTLENQIHRGGe 510
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   355 -----------------------------------FSNGT----------------------------QMEVCQPLTRSD 371
Cdd:TIGR01299 511 ydndkfiglkfksvsfedslfeectfddvtssntfFKNCTfidtlfentdfeeykfidsefqncsflhNKEGCPIDFDGD 590
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   372 -------YFDLLSTTLAEFPGLIITVLIIEWFGRKKTMALEYAVFAIFTFLLYFCLDRFTVTVLIFVARAFISGAFQCAY 444
Cdd:TIGR01299 591 degaymiYFVNFLGTLAVLPGNIVSALLMDKIGRLRMLAGSMVLSCISCFFLSFGNSESAMIALLCLFGGLSIAAWNALD 670
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 32564663   445 VYTPEVYPTTLRAVGLGTCSAMARIGAIVTPFIAQVASEKSLSLPIGIYGTAAILGLIASLSLPiETKGRQMM 517
Cdd:TIGR01299 671 VLTVELYPSDKRATAFGFLNALCKAAAVLGILIFGSFVGITKAAPILFASAALACGGLLALKLP-DTRGQVLM 742
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
94-508 5.42e-36

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 136.95  E-value: 5.42e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  94 MADAMEMMLLSLISPALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFY 173
Cdd:cd17365   9 VLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 174 VLLFFRGLTGFGIGGV-PQSVTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFGWRALMFLSSLPLGIFAV 252
Cdd:cd17365  89 QLALLRFLTGLGLGAAmPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLP 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 253 asfwlpesarfdmasghperaletlqaaarmnrvqlptgrlvsstkagsesrgdianllspdLRKTTILLWCIWAITAFS 332
Cdd:cd17365 169 --------------------------------------------------------------LLRGTLLLWVTFFMGLLL 186
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 333 YYGMVLFTTVLFQshdecHGGLfsngtqmevcqPLTRSDYFDLLSTTLAEFpGLIITVLIIEWFGRKKTMALEYAVFAIF 412
Cdd:cd17365 187 VYLLNSWLPKLMV-----EAGY-----------SLSQALTITLLLNIGGVI-GSLLLGWLADRFGPKRVLALFFALGAVS 249
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 413 TFLLYFCLDRFTVT-VLIFVARAFISGAFQCAYVYTPEVYPTTLRAVGLGTCSAMARIGAIVTPFIAQVASEKSLSLPIG 491
Cdd:cd17365 250 LALLGVSPASLVLLyVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLGPESV 329
                       410
                ....*....|....*....
gi 32564663 492 --IYGTAAILGLIASLSLP 508
Cdd:cd17365 330 flALAIPAALGALAVLLLR 348
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
88-512 2.38e-35

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 138.01  E-value: 2.38e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  88 LTGMAWMADAMEMMLLSLISPALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISG 167
Cdd:cd17363   3 VLGLALMADGVEVFVVGFVLPSAEKDMCLSNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 168 MSPHFYVLLFFRGLTGFGIGG-VPQSVTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFG----------- 235
Cdd:cd17363  83 FVQGYGFFLFCRLLSGIGIGGsIPIVFSYFAEFLAREKRGEHLSWLCMFWMIGGLYASAMAWAIIPHYGwgfsmgtayqf 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 236 --WRALMFLSSLPLGIFAVASFWLPESARFDMASGHPERALETLqaaarmnrvqlptgRLVSSTKAGSESRGDIANLLSP 313
Cdd:cd17363 163 hsWRVFVIVCALPSVASVVALTFMPESPRFLLEVGKHDEAWMIL--------------KQVHDTNMRAKGHPERVFTVSH 228
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 314 DLRKTTILLWCIWAITAFSYYGM-VLFTTVL--FQSHD----ECH-------GGLFSNGT-------------------- 359
Cdd:cd17363 229 IKRMNTLFLAIVWFTMSFSYYGLtVWFPDMIkyLQFEDslfeECYfedvtstNTFFENCTfintvfyntdlfeykfidsr 308
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 360 --------QMEVCQPLTRSD------YFDLLSTTLAEFPGLIITVLIIEWFGRKKTMALEYAVFAIFTFLLYFCLDRFTV 425
Cdd:cd17363 309 flnstfflKEKCGCHLNDDEenayliYLVSFLGSLSVLPGNIVSALLMDKIGRLKMIGGSMLLSAVCCFFLFFGNSESAM 388
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 426 TVLIFVARAFISGAFQCAYVYTPEVYPTTLRAVGLGTCSAMARIGAIVTPFIAQVASEKSLSLPIGIYGTAAILGLIASL 505
Cdd:cd17363 389 IGLQCLFCGVSIAAWNALDVVTVELYPTDKRATAFGFLNGLCKLAAILGNSIFGSFVGITKVIPILLASAALVCGGLLAL 468

                ....*..
gi 32564663 506 SLPiETK 512
Cdd:cd17363 469 KLP-ETR 474
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
79-512 1.01e-33

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 131.15  E-value: 1.01e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  79 GRFQLKLSILTGMAWMADAMEMMLLSLISPALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLV 158
Cdd:COG2271   5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 159 ACIMGVISGMSPHFYVLLFFRGLTGFGIGGV-PQSVTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFGWR 237
Cdd:COG2271  85 WGLATLLFGFATSFWQLLLLRFLLGLGEAGFfPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWR 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 238 ALMFLSSLPLGIFAVASFWlpesarfdmasghperaletlqaaarmnrvqlptgrlvsstkagsesrgdianllspdlrk 317
Cdd:COG2271 165 AAFLILGLPGLLLALLRFW------------------------------------------------------------- 183
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 318 ttiLLWCIWAITAFSYYGMVLFTTVLFQSHdecHGglfsngtqmevcQPLTRSDYFdLLSTTLAEFPGLIITVLIIEWFG 397
Cdd:COG2271 184 ---LLALAYFLVYFALYGFLTWLPTYLVEV---RG------------LSLAQAGLL-LSLPFLAGIVGSLLGGWLSDRLG 244
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 398 R--KKTMALEYAVFAIFTFLLYFCLDRFTVTVLIFVARAFISGAFQCAYVYTPEVYPTTLRAVGLGTCSAMARIGAIVTP 475
Cdd:COG2271 245 RrrKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGP 324
                       410       420       430
                ....*....|....*....|....*....|....*...
gi 32564663 476 F-IAQVASEKSLSLPIGIYGTAAILGLIASLSLPIETK 512
Cdd:COG2271 325 LlVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
87-512 6.50e-33

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 131.20  E-value: 6.50e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  87 ILTGMAWMADAMEMMLLSLISPALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVIS 166
Cdd:cd17438   2 FVLGLALMADGVEVFVVGFVLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 167 GMSPHFYVLLFFRGLTGFGIGG-VPQSVTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFG---------- 235
Cdd:cd17438  82 SFVQGYGAFLFCRLISGFGIGGsLPIVFAYFSEFLAREKRGEHLSWLCMFWMIGGLYASAMAWSIIPHYGwgfsmgtnyh 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 236 ---WRALMFLSSLPLGIFAVASFWLPESARFDMASGHPERALETLQAaarmnrvqlptgrlVSSTKAGSESRGDIANLLS 312
Cdd:cd17438 162 fhsWRVFVIICALPCIASIIALKFMPESPRFLLEMGKHDEAWMILKN--------------IHDTNMRAKGTPEKVFTVS 227
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 313 PDLRKTTILLWCIWAITAFSYYGMVLF---------TTVLFQSH--DECH-------GGLFSNGT--------------- 359
Cdd:cd17438 228 NIKRKNTLFLAVVWFTMAFSYYGLTVWfpdmirylqKHVTFEDSlfDECYfedvtstDTYFKNCTiestifyntdlyehk 307
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 360 -------------QMEVCQPLTRSD-----YFDLLSTTLAEFPGLIITVLIIEWFGRKKTMALEYAVFAIFTFLLYFCLD 421
Cdd:cd17438 308 fidcrfinstfleQKEGCHMDFEEDndfliYLVSFLGSLSVLPGNIISALLMDKIGRIKMIGGSMLISAVCCFFLFFGNS 387
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 422 RFTVT--VLIFVARAFisGAFQCAYVYTPEVYPTTLRAVGLGTCSAMARIGAIV--TPFIAQVASEKslSLPIGIYGTAA 497
Cdd:cd17438 388 ESAMIgwQCLFCGTSI--AAWNALDVITVELYPTNKRATAFGILNGLCKFAAILgnSIFASFVGITK--VIPILLASTAL 463
                       490
                ....*....|....*
gi 32564663 498 ILGLIASLSLPiETK 512
Cdd:cd17438 464 VGGGLISLRLP-ETR 477
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
129-508 8.36e-33

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 128.18  E-value: 8.36e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 129 FSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLLFFRGLTGFGIGGVP-QSVTLYAEFLPTAQRAK 207
Cdd:cd17374  45 MAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISiNTLILGTEWTTPRHRAL 124
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 208 CVVLIESFWAIGAVFEALLAYFVMEsfgWRALMFLSSLPLGIFAVASFWLPesarfdmasghperaletlqaaarmnrvq 287
Cdd:cd17374 125 AITLTSCFFSIGQMLLAGLAYAIRD---WRLLQLVVSVPFFLFFLYSWWLP----------------------------- 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 288 lptgrlvsstkagsesrgdianllspdlrKTTILLWCIWAITAFSYYGMVLFTtvlfqshdechgglfsngtqmevcQPL 367
Cdd:cd17374 173 -----------------------------KRTLILSFVWFANSFSYYGLSLDL------------------------QHL 199
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 368 TRSDYFDLLSTTLAEFPGLIITVLIIEWFGRKKTMALEYAVFAIFTFLLYFC-LDRFTVTVLIFVARAFISGA-FQCAYV 445
Cdd:cd17374 200 GLNVFLLQFLFGAVEVPARCLALFLLNHMGRRISQAVLLLLAGLCILANIFVpQEMQTLRTVLAVLGKGSSAAaFTISYV 279
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 32564663 446 YTPEVYPTTLRAVGLGTCSAMARIGAIVTPFIaQVASEKSLSLPIGIYGTAAILGLIASLSLP 508
Cdd:cd17374 280 YTAELFPTVLRQTGMGLNSMFARIGGILAPLI-MLLGVYSPLLPMIIYGVLPILAGLLALLLP 341
Sugar_tr pfam00083
Sugar (and other) transporter;
117-514 1.08e-30

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 124.31  E-value: 1.08e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   117 SSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSP---HFYVLLFFRGLTGFGIGGVPQSV 193
Cdd:pfam00083  44 LSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKgkwSVYQLIVGRVLVGIGVGGASVLA 123
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   194 TLY-AEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFV---MESFGWRALMFLSSLPLGIFAVASFWLPESARFDMASGH 269
Cdd:pfam00083 124 PMYiSEIAPKKLRGALGSLYQLAITFGILLAYIFGLGLnktSNSDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGR 203
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   270 PERALETLQaaaRMNRVQLPTGRLV----SSTKAGSESRGDIANLLSPDLRKTTILLWCIWA-------ITAFSYYGMVL 338
Cdd:pfam00083 204 LEEAREVLA---KLRGVPDVDRELDeikdSLEAGQEAEKASWKELFSTKTRRQRLLIGVMLQifqqltgINAIFYYSTTI 280
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   339 FTTVLFQshdechGGLFSNGTQMEVcqpltrsdyfDLLSTtlaefpglIITVLIIEWFGRKKTMALEYAVFAIFTFLL-- 416
Cdd:pfam00083 281 FENLGLS------DSFLVTIIVGVV----------NFVFT--------FIAIFLVDRFGRRPLLLLGAAGMAICFVILgi 336
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   417 --YFCLDR-------FTVTVLIFVArAFISGAFQCAYVYTPEVYPTTLRAVGLGTCSAMARIGAIVTPFIAQVASEKSLS 487
Cdd:pfam00083 337 vaLLGVSKsdwagivAIVFIALFIA-FFAMGWGPVPWVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDAIGL 415
                         410       420
                  ....*....|....*....|....*....
gi 32564663   488 LPIGIY--GTAAILGLIASLSLPiETKGR 514
Cdd:pfam00083 416 GYTFFIfaGLLVLFIIFVFFFVP-ETKGR 443
MFS_SV2A cd17439
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...
90-512 6.41e-30

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340997 [Multi-domain]  Cd Length: 478  Bit Score: 122.45  E-value: 6.41e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  90 GMAWMADAMEMMLLSLISPALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMS 169
Cdd:cd17439   5 GLALMADGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 170 PHFYVLLFFRGLTGFGIGG-VPQSVTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFG------------- 235
Cdd:cd17439  85 QGYGTFLFCRLLSGVGIGGsIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGwsfqmgsayqfhs 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 236 WRALMFLSSLPlGIFAVASF-WLPESARFDMASGHPERALETLQAAARMN-RVQLPTGRLVSSTKAGsesrgdianllsp 313
Cdd:cd17439 165 WRVFVLVCAFP-SVFAIGALtTMPESPRFFLENGKHDEAWMVLKQVHDTNmRAKGHPERVFSVTHIK------------- 230
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 314 dlRKTTILLWCIWAITAFSYYGMVLF---------TTVLFQSH--DECH-------GGLFSNGT---------------- 359
Cdd:cd17439 231 --RRITLMMMAVWFTMSFSYYGLTVWfpdmikhlqKSVVFEDSlfEECYfeditssNTFFKNCTfistlfyntdlfeykf 308
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 360 -----------QMEVCQPLTRSD-------YFDLLSTTLAEFPGLIITVLIIEWFGRKKTMALEYAVFAIFTFLLYFCLD 421
Cdd:cd17439 309 insklinstflHNKEGCLLDFSDennaymiYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFGNS 388
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 422 RFTVTVLIFVARAFISGAFQCAYVYTPEVYPTTLRAVGLGTCSAMARIGAIVTPFIAQVASEKSLSLPIGIYGTAAILGL 501
Cdd:cd17439 389 ESAMIALLCLFGGVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAVPILLASAALAAGS 468
                       490
                ....*....|.
gi 32564663 502 IASLSLPiETK 512
Cdd:cd17439 469 SLALKLP-ETR 478
MFS_SLC22A6_OAT1_like cd17446
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...
131-508 8.99e-30

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341004 [Multi-domain]  Cd Length: 339  Bit Score: 119.44  E-value: 8.99e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 131 GMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLLFFRGLTGFGIGG-VPQSVTLYAEFLPTAQRAKCV 209
Cdd:cd17446  45 GVLVGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCVFRFLTGMALSGiVLNSVSLNVEWMPTRVRAVVG 124
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 210 VLIESFWAIGAVFEALLAYFVMEsfgWRALMFLSSLPLGIFAVASFWLPesarfdmasghperaletlqaaarmnrvqlp 289
Cdd:cd17446 125 TLLGYCYTLGQLILAGVAYAIRD---WRWLQLAVSLPFFIFFLYSWWFP------------------------------- 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 290 tgrlvsstkagsesrgdianllspdlrKTTILLWCIWAITAFSYYGMVLfttvlfqshdechgGLFSNGTQMEVCQPLTR 369
Cdd:cd17446 171 ---------------------------RITFCLSLVWFSTSFAYYGLAM--------------DLQKFGVSIYLIQIIFG 209
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 370 SdyfdllsttlAEFPGLIITVLIIEWFGRKKTMALEYAVFAIFTFLLYFC-LDRFTV-TVLIFVARAFISGAFQCAYVYT 447
Cdd:cd17446 210 A----------VDIPAKFISTLTMSYLGRRPTQAAALILAGIMILANIFVpQDLQTVrTALAVFGKGCLAASFNCVYLYT 279
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 32564663 448 PEVYPTTLRAVGLGTCSAMARIGAIVTPfIAQVASEKSLSLPIGIYGTAAILGLIASLSLP 508
Cdd:cd17446 280 GELYPTVIRQTGMGLGSTMARLGGIVAP-LVKMLGEYYPFLPLIIYGAAPILSGIAACFLP 339
MFS_SV2C cd17440
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ...
90-508 1.69e-29

Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340998 [Multi-domain]  Cd Length: 479  Bit Score: 121.17  E-value: 1.69e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  90 GMAWMADAMEMMLLSLISPALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMS 169
Cdd:cd17440   5 GMALMADGVEVFVVGFVLPSAETDMCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSSFV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 170 PHFYVLLFFRGLTGFGIGG-VPQSVTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFG------------- 235
Cdd:cd17440  85 QGYGLFLFCRLLSGFGIGGaVPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGwsfsmgsayqfhs 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 236 WRALMFLSSLPLGIFAVASFWLPESARFDMASGHPERALETLQAAARMNRvqlptgrlvsstkagsESRGDIANLLSPDL 315
Cdd:cd17440 165 WRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKQIHDTNM----------------RARGQPEKVFTVNR 228
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 316 --RKTTILLWCIWAITAFSYYGMVL----------FTTVLFQSH--DECH-------GGLFSNGTQMEV----------- 363
Cdd:cd17440 229 ikKDNTIKLTIVWLTLSFGYYGLSVwfpdvikhlqFKSVTFEDSlfKSCFfedvtsvNTYFRNCTFIETvfyntdledyk 308
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 364 -----------------CQPLTRSD------YFDLLSTTLAEFPGLIITVLIIEWFGRKKTMALEYAVFAIFTFLLYFCL 420
Cdd:cd17440 309 fidsdfinctffhnktgCQITFDDDysaywiYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGT 388
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 421 DRFTVTVLIFVARAFISGAFQCAYVYTPEVYPTTLRAVGLGTCSAMARIGAIVTPFIAQVASEKSLSLPIGIYGTAAILG 500
Cdd:cd17440 389 SESMMIGMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVGITKAIPILLASTVLVCG 468

                ....*...
gi 32564663 501 LIASLSLP 508
Cdd:cd17440 469 GLVGLRLP 476
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
80-471 7.00e-27

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 111.22  E-value: 7.00e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  80 RFQLKLSILTGMAWMADAMEMMLLSLISPALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVA 159
Cdd:COG2814   6 RRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 160 CIMGVISGMSPHFYVLLFFRGLTGFGIGGV-PQSVTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFGWRA 238
Cdd:COG2814  86 ALGSLLCALAPSLWLLLAARFLQGLGAGALfPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRW 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 239 LMFLSSLP-LGIFAVASFWLPESARfdmasghperaletlqaaarmnrvqlptgrlvsstKAGSESRGDIANLLSpdlRK 317
Cdd:COG2814 166 VFLVNAVLaLLALLLLLRLLPESRP-----------------------------------AARARLRGSLRELLR---RP 207
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 318 TTILLWCIWAITAFSYYGMVLFTTVLFQshDECHGGLFSNGTQMevcqpltrsdyfdlLSTTLAEFPGLIITVLIIEWFG 397
Cdd:COG2814 208 RLLLLLLLAFLLGFGFFALFTYLPLYLQ--EVLGLSASAAGLLL--------------ALFGLGGVLGALLAGRLADRFG 271
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 32564663 398 RKKTMALEYAVFAIFTFLLYFCLDRFTVTVLIFVARAFISGAFQCAYVYTPEVYPTTLRAVGLGTCSAMARIGA 471
Cdd:COG2814 272 RRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
109-508 1.81e-26

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 110.25  E-value: 1.81e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 109 ALACEW---GISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLLFFRGLTGFG 185
Cdd:cd17377  26 SIVSEWflvGNAAYKVSLASSFFFAGVLIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRFLVGVM 105
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 186 IGGVPQ-SVTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMEsfgWRALMFLSSLPLGIFAVASFWLPesarfd 264
Cdd:cd17377 106 NGGMSLvAFVLLNECVGKSYWALAGSLGGLFFAVGIAQYALLGYFIRS---WRTLAVVVNLQGTLVFLLSLFIP------ 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 265 masghperaletlqaaarmnrvqlptGRlvsstkagsesrgdianllspdlrktTILLWCIWAITAFSYYGMVLfttvlf 344
Cdd:cd17377 177 --------------------------GR--------------------------TLILMYVWFVCSLVYYGLTL------ 198
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 345 qSHDECHGGLfsngtqmevcqpltrsdYFDLLSTTLAEFPGLIITVLIIE--WFGRKKTMA--LEYAVFA-IFTFLL--- 416
Cdd:cd17377 199 -NAGDLGGNI-----------------YLNLALSGLVELPAYPLCIYLINqkWSGRRRTLAgfLFLGGIAcLLVMFVpek 260
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 417 --YFCLDRFTVTVLIFVARAFISGAFQCAYVYTPEVYPTTLRAVGLGTCSAMARIGAIVTPFIAQVASEKSlSLPIGIYG 494
Cdd:cd17377 261 kdSGVFAVVNSTSLSLLGKLTISAAFNIVYIYTSELYPTVVRNAGLGVCSMFSRVGGIIAPFIPSLKSVQW-SLPFIVFG 339
                       410
                ....*....|....
gi 32564663 495 TAAILGLIASLSLP 508
Cdd:cd17377 340 ASGLSAGLLSLLLP 353
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
104-508 1.68e-24

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 104.43  E-value: 1.68e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 104 SLISPALACEWGISSVQQAL---VTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLLFFRG 180
Cdd:cd17447  17 STFSSTIATEWDLVCDRKGLnqaTATFFFAGVTMGAVAFGYLSDRFGRKRMLLVAYVLSLVFGLASAFSVSYVMFAITRT 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 181 LTGFGIGGVP-QSVTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMEsfgWRALMFLSSLPLGIFAVASFWLPe 259
Cdd:cd17447  97 LTGFALTGFSiISMVLCVEWVDIEHRTVAGVLISLFWTVGNMLLALVAYLIRD---WRWLILAVTLPCAPGIITWWWVP- 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 260 sarfdmasghperaletlqaaarmnRVQLPTGrlvsstkagsesrgdianllspdlrkttillwCIWAITAFSYYGMVLF 339
Cdd:cd17447 173 -------------------------KISLCTG--------------------------------IVWFGVAFTYYGISFN 195
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 340 TTVLfqshdechgglfsnGTQMevcqpltrsdYFDLLSTTLAEFPGLIITVLIIEWFGRKKTMALEYAVFAIFTFLLYFC 419
Cdd:cd17447 196 ISGF--------------GLNV----------YLTQFIYGAIELPAKLLAYLLLDRIGRRLTQAGSLILTGLSIGINILI 251
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 420 LDRFTV--TVLIFVARAFISGAFQCAYVYTPEVYPTTLRAVGLGTCSAMARIGAIVTPFIAqVASEKSLSLPIGIYGTAA 497
Cdd:cd17447 252 PSEFTVvrTVIAVLGKGFSEAAFTTVFLYTSELYPTVLRQNGMGYTSFIARLGGSLAPLVI-LLDDVWLSLPQVIFCGVA 330
                       410
                ....*....|.
gi 32564663 498 ILGLIASLSLP 508
Cdd:cd17447 331 LLAGGVAFLLP 341
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
123-504 5.22e-23

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 100.12  E-value: 5.22e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 123 LVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLLFFRGLTG-FGIGGVPQSVTLYAEFLP 201
Cdd:cd17379  37 LFQSSLNLGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGlFGKGGWMTGYVLVTEFVG 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 202 TAQRAKCVVLIESFWAIGAVFEALLAYFVMEsfgWRALMFLSSLPLGIFAVASFWLPesarfdmasghperaletlqaaa 281
Cdd:cd17379 117 SKYRRTVGIVYQMFFTLGLLILPGIAYFIPH---WRWLQLAVTLPNFLFLLYYWFIP----------------------- 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 282 rmnrvqlptgrlvsstkagsesrgdianllspdlrKTTILLWCIWAITAFSYYGMVLfttvlfqshdecHGGLFSNGTqm 361
Cdd:cd17379 171 -----------------------------------KHTFILMYAWFTSAVVYQGLIM------------RLGITGGNL-- 201
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 362 evcqpltrsdYFDLLSTTLAEFPGLIITVLIIEWFGRKKTMALEYAVFAIFTFLLYFCLDRFT--VTVLIFVARAFISGA 439
Cdd:cd17379 202 ----------YLDFFISALVELPAAFIILLTIDRIGRRLPFAASNIVAGAACLITAFIPPDLHwlKTTIACVGRLGITMA 271
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 32564663 440 FQCAYVYTPEVYPTTLRAVGLGTCSAMARIGAIVTPFIAQVASEKSLSLPIGIYGtaaILGLIAS 504
Cdd:cd17379 272 FEIVCLVNTELYPTFLRNLGVSVCSSLCDIGGIIAPFLLYRLAEIWLELPLIVFG---VLALVAG 333
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
87-515 4.03e-22

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 98.41  E-value: 4.03e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  87 ILTGMAWMADAMEMMLLSLISPALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVIS 166
Cdd:COG2223   8 LLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLL 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 167 GMSPHFYVLLFFRGLTGFGIGGV-PQSVTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFGWRALMFLSSL 245
Cdd:COG2223  88 ALAVSYWLLLLLGLLLGIGGGGSfAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGI 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 246 PLGIFAV-ASFWLPESARFdmASGHPERALETLQAAARmnrvqlptgrlvsstkagsesrgdianllspdlRKTTILLWC 324
Cdd:COG2223 168 LLLVVAVlAWLFLRDPPAG--AAAAAKASLRDQLEALR---------------------------------DPRFWLLSL 212
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 325 IWAITAFSYYGMVLFTTVLFQSHdecHGGLFSNGTQMevcqpltrsdyfdllsTTLAEFPGLIITVL---IIEWFGRKKT 401
Cdd:COG2223 213 LYFGTFGSFIGFSSWLPPYLVDQ---FGLSAATAGLL----------------AALFALLGALGRPLggwLSDRIGGRRV 273
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 402 MALEYAVFAIFTFLLYFCLDRFTV-TVLIFVARAFISGAFQCAYVYTPEVYPTTLRAVGLGTCSAMARIGAIVTPFIAQV 480
Cdd:COG2223 274 LLIVFALMALGLLLLALALGSLWLfLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGA 353
                       410       420       430
                ....*....|....*....|....*....|....*
gi 32564663 481 ASEKSLSLPIGIYGTAAILGLIASLSLPIETKGRQ 515
Cdd:COG2223 354 LLDATGSYTAAFLVFAVLALVALVLTLLLYRRPRR 388
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
79-344 9.37e-22

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 95.65  E-value: 9.37e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  79 GRFQLKLSILTGMAWMADAMEMMLLSLISPALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLV 158
Cdd:COG0477   9 TRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 159 ACIMGVISGMSPHFYVLLFFRGLTGFGIGG-VPQSVTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFGWR 237
Cdd:COG0477  89 FGLASLLCGLAPSPELLIAARALQGIGAGGlMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWR 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 238 AlMFLSSLPLGIFAVASFWLPESARFDMASGHPERALETLQAAARMNRVQLPTGRLVSSTKAGSESRGDIANLLSPDLRK 317
Cdd:COG0477 169 W-IFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLL 247
                       250       260
                ....*....|....*....|....*..
gi 32564663 318 TTILLWCIWAITAFSYYGMVLFTTVLF 344
Cdd:COG0477 248 LALLLLLALLLLAALLLLLLLLLLLAL 274
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
90-507 2.44e-21

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 95.57  E-value: 2.44e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  90 GMAWMADAMEMMLLSLISPALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMS 169
Cdd:cd06174   2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 170 PHFYVLLFFRGLTGFGIGGV-PQSVTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVME--SFGWRALMFLSSLP 246
Cdd:cd06174  82 PSFWLLLLGRFLLGLGSGLIdPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAAAL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 247 LGIFAVASFWLPESARFDMASGHPERALETLqaaarmnrvqlptgrlvsstkagsesrgdIANLLSPDLRKTTILLWCIW 326
Cdd:cd06174 162 ALLAAILLLLVVPDPPESARAKNEEASSKSV-----------------------------LKLLKRVLKNPGLWLLLLAI 212
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 327 AITAFSYYGMVLFTTVLFQSHdecHGGLFSNGTQMevcqpltrsdyfdLLSTTLAEFPGLIITVLIIE-WFGRKKTMALE 405
Cdd:cd06174 213 FLVNLAYYSFSTLLPLFLLDL---GGLSVAVAGLL-------------LSLFGLAGALGSLLLGLLSDrLIGRKPLLLIG 276
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 406 YAVFAIFTFLLYFCLDRFTVTVLIFVARAFISGAFQCAYVYTPEVYPTTLRAVGLGTCSAMARIGAIVTPFIAQVASEKS 485
Cdd:cd06174 277 LLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAT 356
                       410       420
                ....*....|....*....|..
gi 32564663 486 LSLPIGIYGTAAILGLIASLSL 507
Cdd:cd06174 357 FGLTGAFLVLAVLLLLAAILLL 378
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
108-502 2.19e-20

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 93.02  E-value: 2.19e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 108 PALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLLFFRGLTGFGIG 187
Cdd:cd17359  25 PFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVG 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 188 GVPQSVTLY-AEFLPTAQRAKCVvlieSFWAIGAVFEALLAYFV------------MESFGWRALMFLSSLPLGIFAVAS 254
Cdd:cd17359 105 GASALVPMYiAEVAPAEIRGRLV----SLNQLMIVFGQLLAYIVnylianaggadwLGAEGWRWMLGLEAIPAILFLLGM 180
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 255 FWLPESARFDMASGhperaletlqaaarmnrvqlptgrlvsstkagsesrgdianllspdlrKTTILLWCIWA------- 327
Cdd:cd17359 181 LFIPESPRWLVSKG------------------------------------------------KPILIIGIGLAifqqfvg 212
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 328 ITAFSYYGMVLFTTVLFQSHDechgGLFSNgtqmevcqpltrsdyfdlLSTTLAEFPGLIITVLIIEWFGRKKTMALEYA 407
Cdd:cd17359 213 INVIFYYGPEIFQNAGFSENA----ALLQT------------------IGIGVVNVIFTIIAILLVDKVGRKPLLLIGSI 270
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 408 VFAIFTFLLYFCLDRFT------VTVLIFVArAFIsgAFQCA------YVYTPEVYPTTLRAVGLGTCSAMARIG-AIVT 474
Cdd:cd17359 271 GMAISLLLIGTAFYFAPgsqasgIVALVLIL-LFV--AFFAMswgpvtWVLLSEIFPNRIRGLAMGIAVFFLWIAnFLVS 347
                       410       420
                ....*....|....*....|....*...
gi 32564663 475 PFIAQVASEKSLSLPIGIYGTAAILGLI 502
Cdd:cd17359 348 LTFPILLAAFGLAFTFLIFAVICVLAFL 375
MFS_1 pfam07690
Major Facilitator Superfamily;
88-475 3.54e-20

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 91.71  E-value: 3.54e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663    88 LTGMAWMADAMEMMLLSLISPALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISG 167
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   168 MSPHFYVLLFFRGLTGFGIGGV-PQSVTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFGWRALmFLSSLP 246
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALfPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAA-FLILAI 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   247 LGIFAVASFWLPESARFDmasghperaletlqaaarmnrvqlptgrlvSSTKAGSESRGDIANLLSPDLRKTTILLWCIW 326
Cdd:pfam07690 160 LSLLAAVLLLLPRPPPES------------------------------KRPKPAEEARLSLIVAWKALLRDPVLWLLLAL 209
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   327 AITAFSYYGMVLFTTVLFQSHdecHGGLFSNGTQMEVCQpltrsdyfdllsttLAEFPGLIITVLIIEWFGRKKTMALEY 406
Cdd:pfam07690 210 LLFGFAFFGLLTYLPLYQEVL---GLSALLAGLLLGLGG--------------LLGAIGRLLLGRLSDRLGRRRRLLLAL 272
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 32564663   407 AVFAIFTFLLYF---CLDRFTVTVLIFVARAFISGAFQCAYVYTPEVYPTTLRAVGLGTCSAMARIGAIVTP 475
Cdd:pfam07690 273 LLLILAALGLLLlslTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
115-515 9.01e-20

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 92.02  E-value: 9.01e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   115 GISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFY---VLLFFRGLTGFGIGGVPQ 191
Cdd:TIGR00879  67 SYSSSLWGLVVSIFLVGGFIGALFAGWLSDRFGRKKSLLIIALLFVIGAILMGLAAFALsveMLIVGRVLLGIGVGIASA 146
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   192 SVTLY-AEFLPTAQRAKCVVLIESFWAIGAvfeaLLAYFVME-------SFGWRALMFLSSLPLGIFAVASFWLPESARF 263
Cdd:TIGR00879 147 LVPMYlSEIAPKALRGALTSLYQLAITFGI----LVAYGFGSgkvslnnTLGWRIPLGLQLIPAGLLFLGLFFLPESPRW 222
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   264 DMASGHPERALETLQ--------AAARMNRVQLPTGRLVSSTKAGSESRGDIANLLSPDLRK-TTILLWCIWA----ITA 330
Cdd:TIGR00879 223 LVGKGRVEEARKSLArlrgtsgeDKELLDELELIDIKRSIEKRSVQPSWGSLFSSTRRIRRRlFLGVVLQWFQqftgINA 302
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   331 FSYYGMVLFTTVLFQSHDechgGLFSNGTQMEVcqpltrsdyfDLLSTtlaefpglIITVLIIEWFGRKKTMALEYAVFA 410
Cdd:TIGR00879 303 IMYYSPTIFENAGVSTDH----AFLVSIIVGAV----------NFAFT--------FVAIFLVDRFGRRPLLLIGAAGMA 360
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   411 IFTFLLYFCLDRFTV-----------TVLIFVARAFISGAFQCAYVYTPEVYPTTLRAVGLGTCSAMARIGAIV----TP 475
Cdd:TIGR00879 361 ICLFVLGILGASFVTgsskssgnvaiVFILLFIAFFAMGWGPVPWVIVSEIFPLSLRPKGISIAVAANWLANFIvgflFP 440
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*.
gi 32564663   476 FIAQVasekslslpIGIYGTAAILGLIASLSLPI------ETKGRQ 515
Cdd:TIGR00879 441 TMLES---------IGVGGVFIFFGGLNVLGLIFvyfflpETKGRT 477
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
87-511 9.37e-20

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 91.19  E-value: 9.37e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  87 ILTGMAWMADAMEMMLLSLISPALACEWGI-----SSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACI 161
Cdd:cd17364   2 IIAGMGFFTDAYDLFSISLVTKILGRLYYGgkgslPSGVSGLVNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMII 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 162 MGVISGMSPH------FYVLLFFRGLTGFGIGG-VPQSVTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVmesf 234
Cdd:cd17364  82 GTILSALSPGstplgvMGWLIFFRFLLGIGIGGdYPLSATIMSEYANKKRRGALIAAVFAMQGFGILAGAIVTLIL---- 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 235 gwrALMFLSSLPLGifavasfwlpesarfdmasghperaleTLQAAARMNRVQLPTGRlvsstkagsesrgdIANLLSPD 314
Cdd:cd17364 158 ---SAIFEHPLPAG---------------------------TYHHADLVWRIVLGLGA--------------IPALSVLY 193
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 315 LRKTTILLWCIWAITAFSYYGMVLFTTVLFQShdechgglFSNGTQMEVCQPLTRSDYFDLLSTTLAEFPGLIITVLIIE 394
Cdd:cd17364 194 FRKHLLGTAGTWFLLDIAFYGQNLFQSTIISA--------IGFSKTMNAYQELFNIAVGQLIIALAGTVPGYWFTVFLID 265
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 395 WFGRKKTMALEYAVFAIFTFLLYFCLDRF---TVTVLIFVARAFISGAF---QCAYVYTPEVYPTTLRAVGLGTCSAMAR 468
Cdd:cd17364 266 RIGRKKIQMMGFFGMTIFLLILAGPYDHWkisTIGFFVLYGLTFFFSNFgpnTTTFIVPAEVFPARVRSTCHGISAASGK 345
                       410       420       430       440
                ....*....|....*....|....*....|....*....|....
gi 32564663 469 IGAIVTPF-IAQVASEKSLSLPIGIYGTAAILGLIASLSLPIET 511
Cdd:cd17364 346 IGAIVGSFlFLSLTQNIGVRNVLIILAGVALLGIILTLLFPEEK 389
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
113-508 3.61e-19

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 88.57  E-value: 3.61e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 113 EWGI---SSVQQALVTTCVFSGMMLSSTFWGKICD-RFGRRKGLTFSTLVACIMGVISGMSPHFYVLLFFRGLTGFGIGG 188
Cdd:cd17378  24 EWGLicaGSFLVGLPQSSFFVGCLIGSGVLGHLADsSLGRKNLLFLSCLLMALSGIATAFSPNYWVYAFLRFLTGFGRSG 103
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 189 VPQSV-TLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESfgWRALMFLSSLPLGIFAVasFWLPESARFdmas 267
Cdd:cd17378 104 IGTCAlVLATEPVGPKWRGQVGMSTFFFFVLGFMSLPGIAYLNGSS--WRVLYFWTSIPALIYCI--LVYLFARRL---- 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 268 ghperaletlqaaarmnrvqlptgrlvsstkagsesrgdianllspdlrkttILLWCIWAITAFSYYGMVLFTtvlfqsh 347
Cdd:cd17378 176 ----------------------------------------------------LAVMVIGFGIGMVYYGIPLAV------- 196
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 348 dechGGLFSNgtqmevcqpltrsDYFDLLSTTLAEFPGLIITVLIIEWFGRKKTMaLEYAVFAIFTFLLYFCLDRFTVTV 427
Cdd:cd17378 197 ----GNLKFN-------------IYLSVALNALSELPAFVITAFLLDRFGRRPSL-LGFTLLSGASCLLCFVLSIGGTTS 258
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 428 LIFVARAF----ISGAFQCAYVYTPEVYPTTLRAVGLGTCSAMARIGAIVTPFIAqVASEKSLSLPIGIYGTAAILGLIA 503
Cdd:cd17378 259 LQIALELVgffgAAGAFNLLYIYTVELFPTCVRNAALGMLRQALVVGGIFAPFIV-SLGRKNAALSFGVFGVAILLLGLF 337

                ....*
gi 32564663 504 SLSLP 508
Cdd:cd17378 338 ALGLP 342
MFS_SLC22A4_5_OCTN1_2 cd17376
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ...
123-508 7.67e-19

Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340934 [Multi-domain]  Cd Length: 342  Bit Score: 87.91  E-value: 7.67e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 123 LVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPH---FYVLLFFRGLtgFGIGGVPQSVTLYAEF 199
Cdd:cd17376  39 LTTSLFFVGVLLGSFISGQLSDRFGRKKVLFATMAVQTGFSFLQIFSPSwemFTVLFVIVGM--GQISNYVVAFVLGTEI 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 200 LPTAQRAKCVVL-IESFWAIGAVFEALLAYFVMEsfgWRALMFLSSLPlGIFAVASFWLpesarfdmasghperaletlq 278
Cdd:cd17376 117 LGKSVRILFSTLgVCIFYAIGYMLLPLFAYFIRD---WRMLLLALTLP-GVLCVPLWWF--------------------- 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 279 aaarmnrvqLPTgrlvsstkagsesrgdianllspdlrkTTILLWCIWAITAFSYYGMVLFTTVLfqshdecHGGLFSNg 358
Cdd:cd17376 172 ---------IPI---------------------------TTIMSLLLWMAISVGYFGLSLNTPNL-------HGDPYLN- 207
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 359 tqmevcqpltrsdyfdLLSTTLAEFPGLIITVLIIEWFGRKKTMALEYAVFAIFTFLLYFCLDRFTV--TVLIFVARAFI 436
Cdd:cd17376 208 ----------------CFLSAVIEVPAYIIAWLLLRSLPRRYSIAATLVLGGGVLLFIQLVPTDLQVlaTALVMLGKFGI 271
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 32564663 437 SGAFQCAYVYTPEVYPTTLRAVGLGTCSAMARIGAIVTPFIAQVASEKSLsLPIGIYGTAAILGLIASLSLP 508
Cdd:cd17376 272 TAAFSMVYVYTAELYPTVVRNMGVGVCSTASRIGSIISPYFVYLGAYDRY-LPYILMGSLTVLIGILTLFLP 342
2A0109 TIGR00887
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ...
70-514 9.06e-19

phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]


Pssm-ID: 129965 [Multi-domain]  Cd Length: 502  Bit Score: 89.02  E-value: 9.06e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663    70 DEAVEALgFGRFQLKLSILTGMAWMADAMEMMLLSLISPALA-CEWGIS----SVQQALVTTCVFSGMMLSSTFWGKICD 144
Cdd:TIGR00887   3 EEADTAP-FGWQHFRAIVIAGVGFFTDSYDLFCISLVTKMLGyVYYHGKgplpSSVSAAVNGSASIGTLAGQLFFGWLAD 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   145 RFGRRKGLTFSTLVACIMGVISGMSP------HFYVLLFFRGLTGFGIGG-VPQSVTLYAEFLPTAQRAKCVVLIESFWA 217
Cdd:TIGR00887  82 KLGRKRVYGMELIIMIIATVASGLSPgsspksVMATLCFWRFWLGVGIGGdYPLSAIITSEFATKKWRGAMMAAVFAMQG 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   218 IGAVFEALLAYFVMESFG-----------------------WRALMFLSSLPLGIFAVASFWLPESARFDMASGHPERal 274
Cdd:TIGR00887 162 FGILAGAIVALIVLAGFKhsleaaadeasctgscvpavdymWRILIGFGAVPALLALYFRLTIPETPRYTADVAKDVE-- 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   275 etlQAAARMNRVQL--PTGRLVSSTKAGSESRGDIANllSPDL-------RKTTILL-----WCIWAItafSYYGMVLFT 340
Cdd:TIGR00887 240 ---QAASDMSAVLQvkIEAEPDEVEKASTAVEVPKAS--WSDFfthffkwRHGKHLLgtagsWFLLDI---AFYGVNLNQ 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   341 TVLFQSHdechgGLFSNGTQMEVCQPLTRSDYFDLLSTTLAEFPGLIITVLIIEWFGRKKTMALEYAVFAIFTFLLYFCL 420
Cdd:TIGR00887 312 KVILSAI-----GYSPPAATNNAYEELYKTAVGNLIIALAGTVPGYWVTVFLVDIIGRKPIQLMGFFILTVLFFVLGFAY 386
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   421 DRFTVT--VLIFVARAFIS--GAFQCAYVYTPEVYPTTLRAVGLGTCSAMARIGAIVTPF-----IAQVASEKSLSLPIG 491
Cdd:TIGR00887 387 NHLSTHgfLAIYVLAQFFAnfGPNATTFIVPGEVFPTRYRSTAHGISAASGKAGAIIGQFgflylAQHGDPTKGYPTGIW 466
                         490       500
                  ....*....|....*....|....*....
gi 32564663   492 ------IYGTAAILGLIASLSLPiETKGR 514
Cdd:TIGR00887 467 mghvleIFALFMFLGILFTLLIP-ETKGK 494
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
103-502 1.16e-18

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 87.63  E-value: 1.16e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 103 LSLISPALACewGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLLFFRGLT 182
Cdd:cd17315  20 LLYIAKDLGF--GLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLL 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 183 GFGIGGVPQSVTLY-AEFLPTAQRAKCVVLIESFWAIGAVFEALLAY-FVMESFGWRALMF-LSSLPLGIFAVASFWLPE 259
Cdd:cd17315  98 GLGVGLASVLVPLYiSEIAPAKIRGALGTLNQLMITFGILLAYLLGLaLSLSPPGWWRLMFaLAAVPALLQLLLMFFLPE 177
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 260 SARFDMASGhperaLETLQaaarmnrvQLpTGrlvsstkagsesrgdianllspdlrkttillwciwaITAFSYYGmvlf 339
Cdd:cd17315 178 SRALLVGVG-----LQLLQ--------QL-TG------------------------------------INAVMYYA---- 203
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 340 TTVLFQSHDECHGGLFSngtqmevcqpltrsdyfdlLSTTLAEFPGLIITVLIIEWFGRKKTMALEYAVFAIFTFLLYFC 419
Cdd:cd17315 204 PTIFKSAGGGTASILAS-------------------IIVGVVNLLATLVAIRLVDKVGRRPLLLIGFAGMAASLLLLAIA 264
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 420 LDRF----------TVTVLIFVArAFISGAFQCAYVYTPEVYPTTLRAVGLGTCSAMARI-GAIVTPFIAQVASEKSLSL 488
Cdd:cd17315 265 FLLPalakaagwlaLLGILLYIA-AFAMGAGPVPWLLLSEIFPLRIRGKGMAIATLVNWIfNFIVGLTFLIMVSTIGLAG 343
                       410
                ....*....|....
gi 32564663 489 PIGIYGTAAILGLI 502
Cdd:cd17315 344 VFIFFAAVCLLALV 357
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
97-263 1.38e-16

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 81.63  E-value: 1.38e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  97 AMEMMLLSLISPALACE--WGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYV 174
Cdd:cd17362  15 ATSGALLSITSPALSGTdwYNLSSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPV 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 175 LLFFRGLTGFGIGGVPQSVTLY-AEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFGWRALMFLSSLPLG-IFAV 252
Cdd:cd17362  95 LLVGRLIYGVGIGLAMHAAPVYiAETSPSHIRGLLVSLKELFIVLGILLGYVSGYAFADVVGGWRYMYGLAAPPAlLLGI 174
                       170
                ....*....|.
gi 32564663 253 ASFWLPESARF 263
Cdd:cd17362 175 GMWFLPPSPRW 185
MFS_SLC22A16_CT2 cd17375
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ...
131-508 1.21e-15

Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340933 [Multi-domain]  Cd Length: 341  Bit Score: 78.25  E-value: 1.21e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 131 GMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLLFFRGLTGFGIGGVPQSVTLYA-EFLPTAQRAKCV 209
Cdd:cd17375  47 GVLLGAVIFGDIADRIGRRPVLWFTSTGQFVFGIAVAFTFDYYSFVIVRFLLAMVSSGYLVVVFVYVtEFTGIKARTWAS 126
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 210 VLIESFWAIGAVFEALLAYFVMESFGWRALMFLSSLPlgiFAVASFWLPesarfdmasghperaletlqaaarmnrvqlp 289
Cdd:cd17375 127 MHVHAFFAVGIMVVALVGYLVRTWWIYQIILSLVTIP---FILCCWMLP------------------------------- 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 290 tgrlvsstkagsesrgdianllspdlrKTTILLWCIWAITAFSYYgmvlfttvlfqshdechggLFSNGTQmevcqPLTR 369
Cdd:cd17375 173 ---------------------------KRTITVWLIWFTGSLGYY-------------------VFSLGSV-----NLGG 201
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 370 SDYFDLLSTTLAEFPGLIITVLIIEWFGRKKTMALEYAVFAIFTFLLYFCLDRFTV--TVLIFVARAFISGAFQCAYVYT 447
Cdd:cd17375 202 NEYLNLFLVGAVEIPSYIIACIGMDKLGRRNTLAPFLLLSALACMLIMVIPQDYEVltIVLSMTGKFAIAIAFGLIYLYT 281
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 32564663 448 PEVYPTTLRAVGLGTCSAMARIGAIVTPFIAQVASeKSLSLPIGIYGTAAILGLIASLSLP 508
Cdd:cd17375 282 AELYPTIVRSLAVGSGSMMCRVGSVVAPFCVYLSD-VWIFLPQLLVGIMAFLSGILTLMLP 341
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
108-478 1.27e-14

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 75.77  E-value: 1.27e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  108 PALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLLFFRGLTGFGIG 187
Cdd:PRK11551  39 PRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLG 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  188 G-VPQSVTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFGWRALMFLSSL-PLGIFAVASFWLPESARFDM 265
Cdd:PRK11551 119 GaLPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGGVgPLLLVPLLMRWLPESRAFAQ 198
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  266 ASGHPERALETLQAaarmnrvqlptgrlvsstkagsesrgdianLLSPDLRKTTILLWciwaitaFSYygmvLFT-TVLF 344
Cdd:PRK11551 199 AAGAGKQRAPVLRA------------------------------LFGEGRATATLLLW-------ISY----FFTlIVLY 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  345 QshdechggLFSNGTQMEVCQPLTRSD------YFDLlsttlaefpGLIITVLIIEW----FGRKKTMALEYAvfAIFTF 414
Cdd:PRK11551 238 F--------LLNWLPSLLVGQGLSRSQaglvqiAFNI---------GGALGSLLIGAlmdrLRPRRVVLLIYA--GILAS 298
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 32564663  415 LLYFCLDRFTVTVLI--FVARAFISGAFQCAYVYTPEVYPTTLRAVGLGTCSAMARIGAIVTPFIA 478
Cdd:PRK11551 299 LAALAAAPSFAGMLLagFAAGLFVVGGQSVLYALAPLFYPTQVRGTGVGAAVAVGRLGSMAGPLLA 364
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
108-277 1.54e-14

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 75.28  E-value: 1.54e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 108 PALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLLFFRGLTGFGIG 187
Cdd:cd17324  23 PDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHG 102
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 188 GVPQSVTLYA-EFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFGWRALMFLSS-LPLGIFAVASFWLPESARFDM 265
Cdd:cd17324 103 GFWAIAAAYAaDLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAvLALLAALLLWRLLPSLPPKKP 182
                       170
                ....*....|..
gi 32564663 266 ASGHPERALETL 277
Cdd:cd17324 183 GSLGLLSSLLLL 194
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
115-263 1.47e-13

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 72.28  E-value: 1.47e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 115 GISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLLFF-RGLTGFGIGGVPQSV 193
Cdd:cd17356  41 YPSSSRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIGAIIQVAAIGKWYQLIVgRIIAGLGVGFASVLV 120
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 32564663 194 TLY-AEFLPTAQRAKCVVLIESFWAIGAVFEALLAY---FVMESFGWRALMFLSSLPLGIFAVASFWLPESARF 263
Cdd:cd17356 121 PVYqSEVAPKHIRGTLVSLYQLAITIGILVAYCINYgthKLDGSAQWRIPLGLQIVWGLLLLIGMFFLPESPRW 194
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
103-257 1.88e-13

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 71.83  E-value: 1.88e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 103 LSLISPALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLLFFRGLT 182
Cdd:cd17319  22 ISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLL 101
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 32564663 183 GFGIGGVPQSVTLY-AEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFGWRALMFLSSLPLGIFAVASFWL 257
Cdd:cd17319 102 GVAEAGFFPGAIKAlAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFY 177
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
98-253 2.54e-13

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 71.45  E-value: 2.54e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  98 MEMMLLSLIsPALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLLF 177
Cdd:cd17504  11 VETMLSPAL-PTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIA 89
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 32564663 178 FRGLTGFGIGGVPQSVTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFGWRAlMFLSSLPLGIFAVA 253
Cdd:cd17504  90 GRALQGIGGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRW-IFWTAAPVAVLLAA 164
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
128-257 2.74e-13

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 71.06  E-value: 2.74e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 128 VFSGMMLSST----FWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLLFFRGLTGFGIGGV-PQSVTLYAEFLPT 202
Cdd:cd17502  35 VGTAYLLTSTafqpIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLmSLAFIIIADLVPP 114
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 32564663 203 AQRAKCVVLIESFWAIGAVFEALLAYFVMESFGWRALmFLSSLPLGIFAVA---SFWL 257
Cdd:cd17502 115 RERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWC-FYINLPIGGLALAllrTILL 171
PRK03893 PRK03893
putative sialic acid transporter; Provisional
92-508 5.09e-13

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 71.27  E-value: 5.09e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   92 AWMA---DAMEMMLLSLISPALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGM 168
Cdd:PRK03893  25 AWLGyllDGFDFVLITLVLTEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGF 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  169 SPHFYVLLFFRGLTGFGIGG-VPQSVTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFGWRALMFLSSLPL 247
Cdd:PRK03893 105 APGYWTLFIARLVIGMGMAGeYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWGWRALFFIGILPI 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  248 gIFAvasFW----LPESARFDMASGHPERALETLQAAARMNRVQLPTgrLVSSTKAGSESRGDIANLLSpdlrktTILLW 323
Cdd:PRK03893 185 -IFA---LWlrknLPEAEDWKEKHAGKAPVRTMVDILYRGEHRIINI--LLTLAAAAALWFCFAGNLQN------AAIVA 252
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  324 CIWAITAFSYY-------------GMVLFTTVLFqshdechGGLFSNGTQMEVCQPLTRSDYFD-------LLSTTLAEF 383
Cdd:PRK03893 253 VLGLLCAAIFIsfmvqssgkrwptGVMLMVVVLF-------AFLYSWPIQALLPTYLKTDLGYDphtvanvLFFSGFGAA 325
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  384 PGLIITVLIIEWFGRKKTMALEYAVFAIFTFLLyFCLDRFTVT---VLIFVARAFISGAFQCAYVYTPEVYPTTLRAVGL 460
Cdd:PRK03893 326 VGCCVGGFLGDWLGTRKAYVCSLLISQLLIIPV-FAIGGANVWvlgLLLFFQQMLGQGISGLLPKLIGGYFDTEQRAAGL 404
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|.
gi 32564663  461 GTCSAMARIGAIVTPFI-AQVASEKSLSLPIGI--YGTAAILGLIASLSLP 508
Cdd:PRK03893 405 GFTYNVGALGGALAPILgALIAQRLDLGTALASlsFSLTFVVILLIGLDMP 455
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
83-504 7.49e-13

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 70.27  E-value: 7.49e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  83 LKLSILTGMAWMADAMEMMLLSLISPALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIM 162
Cdd:COG0738   7 RRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALG 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 163 GVISGMSPHFYVLLFFRGLTGFGIGGVPQSVTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVM---ESFGWRAL 239
Cdd:COG0738  87 LLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLIllgLSLSWHLP 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 240 MFLSSLPLGIFAVASFwlpesarfdmasghperaletlqaaarmnRVQLPTgrlvsSTKAGSESRGDIANLLSPDLRKTT 319
Cdd:COG0738 167 YLILAVLLLLLALLFL-----------------------------RSKLPE-----IEEEEEEAAGSAASLKSLLKNPRL 212
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 320 ILLWCIWAITAFSYYGMVLFTTVLFQSH---DECHGGLFsngtqmevcqpltrsdyfdLLSTTLAEFPGLIITVLIIEWF 396
Cdd:COG0738 213 LLGGLAIFLYVGAEGAIGDWLPLYLKDVlglSEATAALG-------------------LSLFWGGMTIGRFLGGFLLKRF 273
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 397 GRKKTMALeYAVFAIFTFLLYFCLDRFTVTVLIFVAR-AFISGAFQCAYVYTPEVYPTTlRAVGLGTCSAMARIGAIVTP 475
Cdd:COG0738 274 GPVRLLRL-SALLAAVGLLLALLAPGPWLALIGLALVgLGLSLMFPTIFSLALDGLGKR-TAAAVSAVLIMGIVGGAIGP 351
                       410       420       430
                ....*....|....*....|....*....|....
gi 32564663 476 ----FIAQVAS-EKSLSLPIGIYGTAAILGLIAS 504
Cdd:COG0738 352 pligFLADAFGlRAAFLVPLVCYLLILLLALALK 385
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
117-262 8.25e-13

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 69.61  E-value: 8.25e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 117 SSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLLFFRGLTGFGIGGVPQSVTLY 196
Cdd:cd17360  33 STGWQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGVGIASMTVPLY 112
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 32564663 197 -AEFLPTAQRAKCVVlIESFWAIGAVFEALLAYFVMESF--GWRALMFLSSLPLGIFAVASFWLPESAR 262
Cdd:cd17360 113 iAEAAPPRIRGRLVT-INVLFITGGQFVAYVINGAFSYLpgGWRWMLGLAAVPAVLQFIGLLFLPESPR 180
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
97-253 1.33e-12

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 69.12  E-value: 1.33e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  97 AMEMMLLSLISPALACEWGISSVQQALVTTC---VFSGMMLsstFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFY 173
Cdd:cd17321   9 ALDVTIVNVALPTIARDLGASPSQLQWVVNAyllAFAALLL---LAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLA 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 174 VLLFFRGLTGFGIGG-VPQSVTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFGWRALmFLSSLPLGIFAV 252
Cdd:cd17321  86 FLIAARALQGIGAAAiMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWI-FLINVPIGLVAL 164

                .
gi 32564663 253 A 253
Cdd:cd17321 165 L 165
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
97-261 1.57e-12

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 69.14  E-value: 1.57e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  97 AMEMMLLSLisPALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLL 176
Cdd:cd17320  14 AIDMYLPAL--PAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 177 FFRGLTGFGIGGVpqSVTLYA---EFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFGWRAL-MFLSSLPLGIFAV 252
Cdd:cd17320  92 IARFLQGLGAAAG--SVVARAivrDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIfVFLALLGLLLLLL 169

                ....*....
gi 32564663 253 ASFWLPESA 261
Cdd:cd17320 170 VLLFLPETL 178
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
98-259 1.62e-12

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 69.14  E-value: 1.62e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  98 MEMMLLSLISPAL---ACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYV 174
Cdd:cd17474  10 LAVLGVSIVDPILpaiAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFAL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 175 LLFFRGLTGFGIGG-VPQSVTLYAEFLPTAQRAKCVVLIESFWAIG-AVFEALLAYFVMesFGWRALMFLSSLPLGIFAV 252
Cdd:cd17474  90 LLAGRALQGIGAAGlGPLALTLIGDLFEGGERAKAMGLYEAALGLGiAVGPLLGGLLAA--ISWRYPFFLLAALIPVAFL 167

                ....*..
gi 32564663 253 ASFWLPE 259
Cdd:cd17474 168 AILFLLP 174
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
118-514 3.26e-11

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 65.36  E-value: 3.26e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 118 SVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFST---LVACIMGVISGMSPHFYVLLFFRGLTGFGIGGVPQSVT 194
Cdd:cd17357  48 DLLWSLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNallVVSSLLMFLSKSAKSPELLIFGRFLVGIACGLSTGFVP 127
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 195 LY-AEFLPTAQRAKCVVLIESFWAIGAVFEALLAY-FVMESF-GWRALMFLSSLPLGIFAVASFWLPESARFDMAS-GHP 270
Cdd:cd17357 128 MYlQEISPSELRGALGSLTQIGVTLGILLGQVFGLpSVLGTEtLWPYLLFFPGIPALLQLAALPFFPESPKFLLISkGDE 207
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 271 ERALETLQ--------AAARMNRVQLptgRLVSSTKAGSESRGDIanLLSPDLRKTTILLWCIWA------ITAFSYYGM 336
Cdd:cd17357 208 EEAEKSLKflrgieddVDQELEEIKK---ESEQMGDQKQVSLMQL--LRDPSLRLPLLLVLVVSAsqqfsgINAIFFYST 282
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 337 VLFTTVlfqshdechgglfsnGTQMEVCQPLTrsdyfdlLSTTLAEFPGLIITVLIIEWFGRKK-------TMALEYAVF 409
Cdd:cd17357 283 FIFENA---------------GFSPQLAEWAN-------LGIGIVNVLSTIVGPFLIEKVGRRPlllislsVCAVALLLM 340
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 410 AIFTFLL-------YFCLdrftVTVLIFVArAFISGAFQCAYVYTPEVYPTTLRAVGLGTCSAMARIGAIVTPFIAQvas 482
Cdd:cd17357 341 SVFLFLSeqnswmsYGCI----VAIFLFIF-FFAIGLGPIPWFIGAELFPQAPRSAAQSLGSSVNWTSNFIVGMAFP--- 412
                       410       420       430
                ....*....|....*....|....*....|....*...
gi 32564663 483 ekSLSLPIGIY------GTAAILGLIASLSLPiETKGR 514
Cdd:cd17357 413 --PLQSIGGGFvfiifaIPCALFLLYLYRYLP-ETKGR 447
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
100-507 3.58e-11

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 64.90  E-value: 3.58e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 100 MMLLSLISPAL---ACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLL 176
Cdd:cd17325   9 MLGYGIIIPILplyAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 177 FFRGLTGFGIGGVPQSVTLY-AEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFGWRALMFLSSLPLGI-FAVAS 254
Cdd:cd17325  89 LARFLQGLASAAVWPAAMALiADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLaLVLAL 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 255 FWLPESARfdmasghperaletlqaaarmnrvqlptgrlvSSTKAGSESRGDIANLLSPDLRKTTILLWCIWAITAFSYY 334
Cdd:cd17325 169 LLLPEPRP--------------------------------PPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFG 216
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 335 GMVLFTTVLFQshDECHGGLFSNGtqmevcqpltrsdyFDLLSTTLAEFPGLIITVLIIEWFGRKKTMALEYAVFAIFTF 414
Cdd:cd17325 217 ALEPFLPLYAA--ELGGLSPAQIG--------------LLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALL 280
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 415 LLYFCLDRFTVTVLIFVARAFISGAFQCAYVYTPEVYPTTLRAVGLGTCSAMARIGAIVTPFIAQVASEK-SLSLPIGIY 493
Cdd:cd17325 281 LLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAfGFATPFLAA 360
                       410
                ....*....|....
gi 32564663 494 GTAAILGLIASLSL 507
Cdd:cd17325 361 AALLLLAAVLFLLL 374
PRK12307 PRK12307
MFS transporter;
92-294 9.46e-11

MFS transporter;


Pssm-ID: 237051 [Multi-domain]  Cd Length: 426  Bit Score: 63.79  E-value: 9.46e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   92 AWMA---DAMEMMLLSLISPALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGM 168
Cdd:PRK12307  23 AWLGyvfDGFDFMLIFYIMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGL 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  169 SPHFYVLLFFRGLTGFGIGGVPQSVTLYA-EFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFGWRALMFLSSLPL 247
Cdd:PRK12307 103 ASGVIMLTLSRFIVGMGMAGEYACASTYAvESWPKHLKSKASAFLVSGFGIGNIIAAYFMPSFAEAYGWRAAFFVGLLPV 182
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 32564663  248 GIFAVASFWLPES-----ARFDMASGHPERALETLQAAAR--MNRVQLPTGRLV 294
Cdd:PRK12307 183 LLVIYIRARAPESkeweeAKLSGKGKHSQSAWSVFSLSMKglFNRAQFPLTLCV 236
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
133-276 2.84e-10

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 62.21  E-value: 2.84e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 133 MLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLLFFRGLTGFGIGGV-PQSVTLYAEFLPTAQRAKCVVL 211
Cdd:cd17473  49 ALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGImTLATALIGDYFEGEERAKMLGL 128
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 32564663 212 IESFWAIGAVFEALLAYFVMEsFGWRA--LMFLSSLPLGIFAVasFWLPESARFDMASGHPERALET 276
Cdd:cd17473 129 QSAAMSLGGVVFLLLGGALAE-IGWRApfLVYLLALPVLILVL--LFLPEPARKSKSAASPGAATAA 192
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
115-263 3.10e-10

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 61.83  E-value: 3.10e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 115 GISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLLFFRGLTGFGIGGVPQSVT 194
Cdd:cd17330  30 GASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSVAQA 109
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 195 LYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFGWRALMFLSS-LPLGIFAVASFWLPESARF 263
Cdd:cd17330 110 YIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAaLALLNLVLVLFFLPPLRRL 179
MFS_GLUT12_Class3 cd17435
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
103-263 1.36e-09

Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340993 [Multi-domain]  Cd Length: 376  Bit Score: 59.81  E-value: 1.36e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 103 LSLISPAL---ACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLLFFR 179
Cdd:cd17435  17 LGIISGALlqlRTLLALSCHEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILTSCLLVLGSLLLVCSVSYTVLIVGR 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 180 GLTGFGIGGVPQSVTLY-AEFLPTAQRAKCVVLIESFWAIGAVFEALLAY-FVMESFGWRaLMFLSSLPLGIF-AVASFW 256
Cdd:cd17435  97 IAIGVSISLSSIATCVYiAEIAPQHRRGLLVSLNELMIVIGILLAYISNYaFANVSNGWK-YMFGLVIPLAALqAIAMYF 175

                ....*..
gi 32564663 257 LPESARF 263
Cdd:cd17435 176 LPPSPRF 182
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
103-277 4.93e-09

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 58.35  E-value: 4.93e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 103 LSLISPALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLLFFRGLT 182
Cdd:COG2807  37 VGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALI 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 183 GFGIG-GVPQSVTLYAEFLPtAQRAKCVVLIESFWAIGAVFEALLAYFVMESFGWR-ALMFLSSLPLGIFAVASFWLPES 260
Cdd:COG2807 117 GAGIAvGNVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRgALAVWALLALLALLLWLPLLRRR 195
                       170
                ....*....|....*..
gi 32564663 261 ARFDMASGHPERALETL 277
Cdd:COG2807 196 PAAAAAAPAAASLRSLW 212
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
86-516 9.69e-09

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 57.59  E-value: 9.69e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  86 SILTGMA--WMADAMemmllSLISPALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFStLVACIMG 163
Cdd:cd17358  11 SFSFGIAvgWSSPAL-----PSLMSDNSLSLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLIS-AIPCILG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 164 VISGM-SPHFYVLLFFRGLTGFGIGGVPQSVTLY-AEFLPTAQRAKCVVLIESFWAIGAvfeaLLAYFVMESFGWRALMF 241
Cdd:cd17358  85 WLLIAfAKDVWMLYLGRFLAGFGGGAASVVVPVYiAEIAPKNVRGALGSLNQLLVNIGI----LLGYVLGSFLPWRTLAL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 242 LSSLPLGIFAVASFWLPESARFDMASGHPERALETLQ-----------AAARMNRVQLPTGRLVSSTKagsesrgdIANL 310
Cdd:cd17358 161 IGAIPPVVFLILLFFIPESPRWLAKKGREEEAEKSLQflrgkdadiskEAAEIQEELAELEKEAKESS--------FSDL 232
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 311 LSPDLRKTTILLWCIWAITAFS-YYGMVLFTTVLFqshDECHGGLFSNGTQMEVCqpltrsdyfdllsttLAEFPGLIIT 389
Cdd:cd17358 233 FQRKYLKPLVIGLGLMLFQQLSgINAVIFYASSIF---DEAGSGLDPNTATIIIG---------------VVQVVGTLVA 294
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 390 VLIIEWFGRKKTMALEYAVFAIFTFLL--YFCLDRFT-----------VTVLIFVArAFISGAFQCAYVYTPEVYPTTLR 456
Cdd:cd17358 295 TLLVDRLGRRPLLLVSAIGMGIGLLALglYFYLQEHGallssvswlplVGLVIYII-SFSIGLGPLPWVIMSEIFPAKIK 373
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 32564663 457 AVGLGTCSAMARIGA-IVTPFIAQVASEKSLSLPIGIYGTAAILGLIASLSLPIETKGRQM 516
Cdd:cd17358 374 GLAGSLVTLVNWLFAfIVTKTFPFLTLAWGASGTFWIFAGICGLALVFVLLFVPETKGKSL 434
2_A_01_02 TIGR00880
Multidrug resistance protein;
131-260 1.04e-08

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 53.81  E-value: 1.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   131 GMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLLFFRGLTGFGiGGVPQSVT--LYAEFLPTAQRAKC 208
Cdd:TIGR00880  10 GQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFG-AAFALVAGaaLIADIYPPEERGVA 88
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 32564663   209 VVLIESFWAIGAVFEALLAYFVMESFGWRAL-MFLSSLPLGIFAVASFWLPES 260
Cdd:TIGR00880  89 LGLMSAGIALGPLLGPPLGGVLAQFLGWRAPfLFLAILALAAFILLAFLLPET 141
MFS_STP cd17361
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ...
123-260 2.26e-08

Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340919 [Multi-domain]  Cd Length: 390  Bit Score: 56.10  E-value: 2.26e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 123 LVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLLFFRGLTGFGIGGVPQSVTLY-AEFLP 201
Cdd:cd17361  55 LFTSSLYLAGLVASLLASYVTRKWGRKPSMLIGGVLFLVGAALNAAAQNIAMLIVGRILLGFGVGFGNQAVPLYlSEMAP 134
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 32564663 202 TAQRAKCVVLIESFWAIGAVFEALLAYFV--MESFGWRALMFLSSLPLGIFAVASFWLPES 260
Cdd:cd17361 135 AKLRGALNIGFQLAITIGILIANLINYGTskIKPNGWRLSLGLAAVPALILLLGSLFLPET 195
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
71-253 2.83e-08

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 55.64  E-value: 2.83e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  71 EAVEALGFGRFQLKLSILTGMAWMADAMEMMLLSLIsPALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRK 150
Cdd:cd17477 176 EEAESISLRRLLRIAPLALLGAFVAGFLEGAFYSLL-PLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRR 254
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 151 GLTFSTLVACIMGV----ISGMSPHFYVLLFFRGLTGFGIggVPQSVTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALL 226
Cdd:cd17477 255 VLLGCALLGALAALllplVPGLPLALLVLLFLWGGAAGPL--YTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLL 332
                       170       180
                ....*....|....*....|....*..
gi 32564663 227 AYFVMESFGWRALMFLSSLPLGIFAVA 253
Cdd:cd17477 333 AGALMDAFGPHGLFLFLAAVALLFLLF 359
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
108-259 3.83e-08

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 55.27  E-value: 3.83e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 108 PALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLLFFRGLTGFGiG 187
Cdd:cd17323  23 PQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFF-G 101
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 32564663 188 GVPQSVT--LYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFGWRALM-FLSSLPLGIFAVASFWLPE 259
Cdd:cd17323 102 SSPLAIGagTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFwFLAIISGFCLILIFLFLPI 176
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
100-291 6.81e-08

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 54.52  E-value: 6.81e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 100 MMLLSLIsPALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLLFFR 179
Cdd:cd17489  13 YLLLPVL-PLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLR 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 180 GLTGFGIGGVPQ-SVTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFGWRALMFLSSlplgIFAVASFWLP 258
Cdd:cd17489  92 LIHGIGWGAFTTaAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAA----VLALLALLLV 167
                       170       180       190
                ....*....|....*....|....*....|...
gi 32564663 259 ESARFDMASGHPERALETLQAAARMNRVQLPTG 291
Cdd:cd17489 168 FLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPA 200
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
87-269 7.10e-08

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 54.48  E-value: 7.10e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  87 ILTGMAWMADAMEMMLLSLISPALACEWGISSVQQalvttcvfsGMMLSSTFWG---------KICDRFGRRKGLTFStl 157
Cdd:cd17380   2 ILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQ---------GLVLSSFFWGyaltqvlggYLADRFGGKKVLLLA-- 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 158 vACIMGVISGMSPHF-----YVLLFFRGLTGFGIG-GVPQSVTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVM 231
Cdd:cd17380  71 -VALWSLATLLTPLLaysslPLLILSRILLGLGEGvHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLL 149
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 32564663 232 ESFGWRAlMFLSSLPLGI-------FAVASFWLPESARFDMASGH 269
Cdd:cd17380 150 EYYGWPS-VFYFFGLLGLlwalvwlIYLPPVWAIIVAHFCMNWGF 193
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
138-505 1.56e-07

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 53.45  E-value: 1.56e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 138 FWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHF--------YVLLFFRGLTGFGIGG-VPQSVTLYAEFLPTAQRAkc 208
Cdd:cd17367  59 LFGRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYatigiwapIILLLARLLQGLSVGGeYGTSATYLSEVAPPGRRG-- 136
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 209 vvLIESFWAIGAVFEALLAYFV------------MESFGWRALMFLSslplGIFAVASFWL----PESARFDMASGHPER 272
Cdd:cd17367 137 --FYSSFQYVTLIGGQLLALGVllvlqhtlgedqMAAWGWRIPFLLG----GVLAVVVLWLrrglEETESFEAIAESNEA 210
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 273 ALETLQAAARMNRVQLptgRLVSSTKAGSesrgdianllspdlrkttiLLWCIWAITAFSYygmvLFTTVLFQSHDECHG 352
Cdd:cd17367 211 SAGTLRELRRHPRELL---LVVGLTAGGT-------------------LAFYTWTTYLQKF----LVNTAGFSKGDATWI 264
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 353 GLFSNGTQMeVCQPLTrsdyfDLLSttlaefpgliitvliiEWFGRKKTMALEYAVFAIFTFLLYFCLDR----FTVTVL 428
Cdd:cd17367 265 TTAALLVFM-LLQPLG-----GRLS----------------DRIGRRPLLLFFGIGGTLATVPLLSALDHtdspYTAFAL 322
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 32564663 429 IFVARAFISGAFQCAYVYTPEVYPTTLRA--VGLGTCSAMARIGAiVTPFIAQvaSEKSLSLPIGIYGTAAILGLIASL 505
Cdd:cd17367 323 VLVGLVFLSGYTSINAVVKAELFPTHVRAlgVGLPYALAVAIFGG-TAPYVAL--WLKSIGHEWVFFWYVAGLIAISLV 398
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
85-257 1.93e-07

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 53.35  E-value: 1.93e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  85 LSILTGMAWMAdamemMLLSLISPALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGV 164
Cdd:cd17325 206 LAIFVLAFAFG-----ALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALL 280
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 165 ISGMSPHFYVLLFFRGLTGFGIGGV-PQSVTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFGWRALMFLS 243
Cdd:cd17325 281 LLPLATSFWLLLLLLALLGLGLGLVfPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAA 360
                       170
                ....*....|....
gi 32564663 244 SLPLGIFAVASFWL 257
Cdd:cd17325 361 AALLLLAAVLFLLL 374
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
102-264 2.01e-07

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 53.54  E-value: 2.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   102 LLSLISPALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLLFFRGL 181
Cdd:TIGR00711  20 IVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVI 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   182 TGFGIGG-VPQSVTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFGWRaLMFLSSLPLGIFAVASFWL--- 257
Cdd:TIGR00711 100 QGFGGGPlIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWR-WIFLINVPIGIIVVVVAFFilp 178
                         170
                  ....*....|.
gi 32564663   258 ----PESARFD 264
Cdd:TIGR00711 179 rdkpAASENFD 189
xylE PRK10077
D-xylose transporter XylE; Provisional
131-518 2.28e-07

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 53.16  E-value: 2.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  131 GMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISgMSPHF-----------YVLLF--FRGLTGFGIGGVPQSVTLY- 196
Cdd:PRK10077  67 GCIIGGALGGYCSNRFGRRDSLKIAAVLFFISALGS-AWPEFgftsigpdntgYVPEFviYRIIGGIGVGLASMLSPMYi 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  197 AEFLPTAQRAKCVvlieSFWAIGAVFEALLAYFV------------MESFGWRaLMFLS-SLPLGIFAVASFWLPESARF 263
Cdd:PRK10077 146 AEIAPAHIRGKLV----SFNQFAIIFGQLVVYFVnyfiarsgdaswLNTDGWR-YMFASeAIPALLFLMLLYFVPETPRY 220
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  264 DMASGHPERALETLQaaarmnrvqlptgRLVSSTKAGSESRgDIANLLSPDLRKTTILlwciwaitaFSYYGMVLFTTVL 343
Cdd:PRK10077 221 LMSRGKQEQAEGILR-------------KIMGNTLATQALQ-EIKHSLDHGRKTGGKL---------LMFGVGVIVIGVM 277
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  344 ---FQSHDECHGGLFsngTQMEVCQPLTRSDYFDLLSTTLAEFPGLIITVLII---EWFGRKKTMALEYAVFAIFTFLLY 417
Cdd:PRK10077 278 lsvFQQFVGINVVLY---YAPEIFKTLGASTDIALLQTIIVGVINLTFTVLAImtvDKFGRKPLQIIGALGMAIGMFSLG 354
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  418 FCL-----DRFTVTVLIFVARAFISGAFQCAYVYTPEVYPTTLRavglGTCSAMARIGAIVTPFI-----------AQVA 481
Cdd:PRK10077 355 TAFytqapGIVALLSMLFYVAAFAMSWGPVCWVLLSEIFPNAIR----GKALAIAVAAQWIANYFvswtfpmmdknSWLV 430
                        410       420       430
                 ....*....|....*....|....*....|....*..
gi 32564663  482 SEKSLSLPIGIYGTAAILGLIASLSLPIETKGRQMMD 518
Cdd:PRK10077 431 AHFHNGFSYWIYGCMGVLAALFMWKFVPETKGKTLEE 467
MFS_PLT cd17437
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ...
115-263 8.28e-07

Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340995 [Multi-domain]  Cd Length: 387  Bit Score: 51.25  E-value: 8.28e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 115 GISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLLFFRGLTGFGIGGVPQSVT 194
Cdd:cd17437  28 KISDVQEEVLIGSLNIISLVGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGVAPNYPVLMVGRFVAGIGVGFALMIAP 107
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 32564663 195 LY-AEFLPTAQRAKCVVLIESFWAIGAVFEALLAYF---VMESFGWRALMFLSSLPLGIFAVASFWLPESARF 263
Cdd:cd17437 108 VYtAEVAPASSRGFLTSFPEIFINIGILLGYVSNYAfsgLPLHVGWRLMLGVGAVPSLFLAIGVLAMPESPRW 180
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
101-257 1.10e-06

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 50.74  E-value: 1.10e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 101 MLLSLISPALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLLFFRG 180
Cdd:cd17312  20 KNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWG 99
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 32564663 181 LTGF--GIGGVPQSVTLYAEFLPtAQRAKCVVLIESFWAIGAVFEALLAYFVMESFGWRALMFLSSLPLGIFAVASFWL 257
Cdd:cd17312 100 LNGLfqSMGWPPCVKLLGNWFSK-KERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFF 177
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
92-256 1.99e-06

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 49.96  E-value: 1.99e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  92 AWMADAMEMMLLSLISPALAC---EWGISSVQQA-----LVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMG 163
Cdd:cd17391   1 CWLGNFFTGIGFSLIAPFLPLyieQLGVTSGGLVelwsgLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 164 VISGMSPHFYVLLFFRGLTGFGIGGVPQSVTLYAEFLPTAqrakcvvliESFWAIGAVFEA---------LLAYFVMESF 234
Cdd:cd17391  81 GLMAFVTNVWQLLILRLLQGVFSGYVPNATALIASQTPKE---------KSGWALGTLSTGvvagtligpLLGGFLADLF 151
                       170       180
                ....*....|....*....|..
gi 32564663 235 GWRALMFLSSlplGIFAVASFW 256
Cdd:cd17391 152 GIRNVFFITG---GLLFLAFLL 170
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
98-254 2.17e-06

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 49.88  E-value: 2.17e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  98 MEMMLLSLIS---PALACEWGISSVQQALVTTC--VFSGMMLSSTFWgkICDRFGRRKGLTFSTLVACIMGVISGMSPHF 172
Cdd:cd17503   7 MAILDTTIVNvalPTIMGDLGASLDTVQWVITSylLALAIMIPLSGW--LADRFGTRRLFLTALALFTLGSLLCGLAPNL 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 173 YVLLFFRGLTGFGIGG-VPQSVTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFGWRAlMFLSSLPLGIFA 251
Cdd:cd17503  85 ASLIIFRILQGFGGGVlIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRW-IFYINLPIGILA 163

                ...
gi 32564663 252 VAS 254
Cdd:cd17503 164 LLL 166
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
85-283 2.36e-06

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 49.85  E-value: 2.36e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  85 LSILTGMAWMADAMEMMLLSLIspaLACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLtfsTLVACIMGV 164
Cdd:cd17471   1 LLLATLLTGLAGAFVLPYLSLF---LTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGDRKPL---ILLALLAGA 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 165 IS----GMSPHFYVLLFFrGLTGFGIGG--VPQSVTL---YAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFG 235
Cdd:cd17471  75 LGyllfAFLRNYWVLLLV-GVVLLSLGAaaFPQLFALareYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLG 153
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 32564663 236 WRALMFLSSLPLGIFAVASFWLPESARFDMASGHPERALETLQAAARM 283
Cdd:cd17471 154 FTGLFLLAALLYLVVALLVLFLLPSVKPPAQKATPASSLVKAPVNRRL 201
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
90-237 2.76e-06

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 49.93  E-value: 2.76e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  90 GMAWMADAMEMMLLSLISPALACEWGiSSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMS 169
Cdd:cd06179   4 CLAYFAQLFGVTLPAAVLPFIVADLG-PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTA 82
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 170 PHFYVLLFFRGLTGFGIGGVPQSVTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESF--GWR 237
Cdd:cd06179  83 KSVNMLIGGQALIGIGAGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANaaGWR 152
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
94-260 2.86e-06

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 49.63  E-value: 2.86e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  94 MADAMEMMLLSLISPALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFY 173
Cdd:cd17333   6 FSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 174 VLLFFRGLTGFGIG-----GVPQSVTLYAEFLPTAqrakcVVLIESFWAIGAVFEALLA-YFVMESFGW---RALMFLSS 244
Cdd:cd17333  86 LFVVLMFLAGLGAGildtgANTFVGALFEESSATR-----LNVLHGFFGLGALIGPLIAtSLLTSELSWswaYLIIGLIY 160
                       170
                ....*....|....*.
gi 32564663 245 LPLGIFAVASFWLPES 260
Cdd:cd17333 161 LLLAILILLTLFPELP 176
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
122-256 3.12e-06

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 49.57  E-value: 3.12e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 122 ALVTTCVFSGM----MLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLLFFRGLTGFGIGG-VPQSVTLY 196
Cdd:cd17391 239 AFISGLVFSATgvssLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGlLPAINSLL 318
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 197 AEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFGWRALMFLSSLPLGIFAVASFW 256
Cdd:cd17391 319 AKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWSFI 378
MFS_SLC22A31 cd17443
Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier ...
127-256 3.56e-06

Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier family 22, member 31 (SLC22A31) is an uncharacterized member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A31 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341001 [Multi-domain]  Cd Length: 343  Bit Score: 49.00  E-value: 3.56e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 127 CVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLLFFRGLTGFGIGGVPQSVTLY-AEFLPTAQR 205
Cdd:cd17443  44 SYLLGWLLGYIILGAGCDRLGRRAAFVLSLVLATLLGVSVALSASPPTFLVLRLLQGGTLAGVFLSLYIArLELCDPSHR 123
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 32564663 206 AKCVVLIESFWAIGavfEALLAYFVMESFGWRALMFLSSLPLGIfaVASFW 256
Cdd:cd17443 124 LMVSMGAGFFSVAG---ELLLPGLAVLCRDWRVLQGVGTLPLLL--LLLYW 169
MFS_GLUT10_Class3 cd17436
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
99-261 3.71e-06

Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340994 [Multi-domain]  Cd Length: 376  Bit Score: 49.03  E-value: 3.71e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  99 EMMLLSLISPALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLLFF 178
Cdd:cd17436  16 ELGIISGALLQLQTDFSLSCFEQEALVSALLIGALLASLIGGFLIDRHGRRTSILGSNLVLLAGSLILTLAGSFFWLVIG 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 179 RGLTGFGIGGVPQSVTLY-AEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVME-SFGWRALMFLSSLPLGIFAVASFW 256
Cdd:cd17436  96 RAVVGFAISVSSMACCIYvSEMVTPHQRGLLVSLYEAGITVGILISYALNYFFSNvLTGWRYMFGLAIIPAAIQFASILL 175

                ....*
gi 32564663 257 LPESA 261
Cdd:cd17436 176 LPKKP 180
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
55-257 5.65e-06

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 48.77  E-value: 5.65e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  55 PTDQRSPDSEKTFTVDEAVEALGFGRFQLKLSILTGMAWMADAMEMMLLSLISPALACEWGISSVQQALVTTCVFSGMML 134
Cdd:cd06173 180 RPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALL 259
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 135 SSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLLFFRGLTGFGIG-GVPQSVTLYAEFLPTAQRAKCVVLIE 213
Cdd:cd06173 260 GALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGlFNVPLNTLLQLRVPDELRGRVFSVYN 339
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 32564663 214 SFWAIGAVFEALLAYFVMESFGWRALMFLSSLPLGIFAVASFWL 257
Cdd:cd06173 340 ALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
132-257 7.24e-06

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 48.36  E-value: 7.24e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 132 MMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLLFFRGLTGFGIGGVPQSVTLYAEFL-PTAQRAKCVV 210
Cdd:cd17489 240 LLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLvPPHRRGAANG 319
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 32564663 211 LIESFWAIGAVFEALLAYFVMESFGWRALMFLSSLPLGIFAVASFWL 257
Cdd:cd17489 320 TFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFL 366
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
102-257 1.06e-05

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 47.62  E-value: 1.06e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 102 LLSLISPALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLLFFRGL 181
Cdd:cd17328  17 TIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRAL 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 182 TGFGIGGV-PQSVTLYAEFLPTAQRAKcvVLieSFWAIGAVFEALLAYFV-----MESFGWRAlMFLSSLPLGIFAVASF 255
Cdd:cd17328  97 VGIGEASYsPIAPTIIADLFPKEKRTR--AL--GVFYFAIPLGSGLGYVVgglvaQATGGWRW-AFRVTGVLGVLLAILL 171

                ..
gi 32564663 256 WL 257
Cdd:cd17328 172 LL 173
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
91-260 1.07e-05

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 47.99  E-value: 1.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   91 MAWMADAMEMMLLSLISPALAC---EWGIS-----SVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIM 162
Cdd:PRK09874  18 VAWLGCFLTGAAFSLVMPFLPLyveQLGVTghsalNMWSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIV 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  163 GVISGMSPHFYVLLFFRGLTGFGIGGVPQSVTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFGWRALMFL 242
Cdd:PRK09874  98 MVLMGLAQNIWQFLILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADSYGLRPVFFI 177
                        170
                 ....*....|....*....
gi 32564663  243 SSLPLGI-FAVASFWLPES 260
Cdd:PRK09874 178 TASVLFLcFLVTLFCIREN 196
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
102-509 1.13e-05

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 47.55  E-value: 1.13e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 102 LLSLISPALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLLFFRGL 181
Cdd:cd17478  14 FLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVAL 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 182 TGFGIGGV-PQSVTLyAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFGWRAlMFLSSLPLGIFAVASFWlpes 260
Cdd:cd17478  94 AGIGSAAFhPEGARL-ASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLG-LLILLIIPGLAVALLLL---- 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 261 arfdmasghperaletlqaaaRMNRVQLPTGRLVSSTKAGSESRGDIANLLspdlrkttILLWCIWAITAFSYYGMVLFT 340
Cdd:cd17478 168 ---------------------RLRPLKKPEAKKAAAKSSARSTLKGVWRAL--------LLLLIIVFLRSWVLSSLTTFL 218
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 341 TVLFQSHdecHGGLFSNGTqmevcqpltrsdyfdLLSTTLaeFPGLIITVL---IIEWFGRKKTMALEYAVFAIFTFLLY 417
Cdd:cd17478 219 PFYLVQR---GYSLVFAGL---------------LLSLFL--FAGAIGTLIggpLSDRFGRRRVIIASLLLAAPFLLLFL 278
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 418 FCLDRFTVtVLIFVARAFISGAFQCAYVYTPEVYPTTLRAVG---LGTCSAMARIGAIVTPFIAQVasekslslpIGIYG 494
Cdd:cd17478 279 LTPGIWSY-ILLVLAGFLLFASFPVTVVLAQELLPGNVGLASglmMGLSFGLGGIGAPVLGALADA---------FGLES 348
                       410
                ....*....|....*
gi 32564663 495 TAAILGLIASLSLPI 509
Cdd:cd17478 349 VLLILALLPLLGALL 363
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
106-282 1.42e-05

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 47.23  E-value: 1.42e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 106 ISPALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLLFFRGLTGFG 185
Cdd:cd17475  18 LAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAG 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 186 IGGV-PQSVTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFGWRALMFLSSLPLGIFAVASF-WLPESARF 263
Cdd:cd17475  98 YGSVqPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWlFYREPPAA 177
                       170
                ....*....|....*....
gi 32564663 264 DMASGHPERALETLQAAAR 282
Cdd:cd17475 178 SAATESASTLLRSLKEVLR 196
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
83-258 4.04e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 46.05  E-value: 4.04e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  83 LKLSILTGMAWMAdamEMMLLSLISPALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIM 162
Cdd:COG2211 231 LLLLLAYLLFFLA---LALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG 307
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 163 GVISGMSPHFYVLLFFRGLTGFGIGGVPQSVTLYAEF--LPTAQRAKCVVLIES--------FWAIGAVFEALLAYFVME 232
Cdd:COG2211 308 LLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLadVVDYDEWKTGRRREGlyfgiftfAIKLGQALAGALAGLLLA 387
                       170       180
                ....*....|....*....|....*.
gi 32564663 233 SFGWRALMFLSSLPLGIFAVASFWLP 258
Cdd:COG2211 388 LFGYVAGAAQSPSALTGIRLLFFLLP 413
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
113-259 1.10e-04

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 44.60  E-value: 1.10e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 113 EWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACI-MGVISGMSPHFYVLLFFRGLTGFGIGGVPQ 191
Cdd:cd17371 239 ERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAIsILLYFFLPLSPTLILILGFPLGFFASGPFS 318
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 192 SVTLY-AEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFGWR-ALMFLSSLPLGIFAVASFWLPE 259
Cdd:cd17371 319 GMGAYlTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGtAIAVFAAVYYIAGLVLALLLPE 388
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
102-257 1.13e-04

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 44.67  E-value: 1.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   102 LLSLISPALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLLFFRGL 181
Cdd:TIGR00881  13 NFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWAL 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   182 TGF--GIGGVPqSVTLYAEFLPTAQRAKCVvlieSFWAI-----GAVFEALLAYFVMESFGWRALMFLSSLPLGIFAVAS 254
Cdd:TIGR00881  93 NGIfqGMGWPP-CGRTVTKWFSRSERGTWV----SFWNCshnvgGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLIC 167

                  ...
gi 32564663   255 FWL 257
Cdd:TIGR00881 168 FLL 170
MFS_SLC22A17_like cd17373
Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; ...
131-258 1.58e-04

Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; This group is composed of Solute carrier family 22, members 17, 23, and 31. They are members of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). SLC22A17 functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. SLC22A23 and SLC22A31 are orphan members of the SLC22 family. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22A17-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340931 [Multi-domain]  Cd Length: 348  Bit Score: 44.05  E-value: 1.58e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 131 GMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLLFFRGLTGFGIGGVpqSVTLYA---EFLPTAQRAK 207
Cdd:cd17373  37 GLIFGYLILGCIADRFGRRPVLLFSLILILIFGLTVALAVSVTMFSTLRFLEGFCLAGI--ILTLYLlrlELCDPGKRLM 114
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 32564663 208 cVVLIESFWAIGAVFeaLLAYFVMESFGWRALMFLSSLPLGIFAVasFWLP 258
Cdd:cd17373 115 -ITMVASLVAVAGQF--LMPGLAALCRDWRVLQALIICPFLLMLL--YWSI 160
MFS_GLUT6_Class3 cd17434
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
144-277 1.67e-04

Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340992 [Multi-domain]  Cd Length: 417  Bit Score: 44.05  E-value: 1.67e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 144 DRFGRRKGLTFSTLVACIMGVISGMSPHFYVLLFFRGLTGFGIGGVPQSVTLY-AEFLPTAQRAkcvvLIESFWAIGAVF 222
Cdd:cd17434  66 DRLGRKLSIMFSAVPSALGYLLMGSAQGIWMLLLGRFLTGFAGGITAASIPVYvSEISHPGVRG----ALGACPQIMAVF 141
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 32564663 223 EALLAYFVMESFGWRALMFLSSLPLGIFAVASFWLPESARFDMASGHPERALETL 277
Cdd:cd17434 142 GSLALYALGLLLPWRWLAVAGEVPVVIMILLLCFMPNSPRFLISKGKDEKALKAL 196
MFS_1 pfam07690
Major Facilitator Superfamily;
379-507 1.75e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 43.95  E-value: 1.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   379 TLAEFPGLIITVLIIEWFGRKKTMALEYAVFAIFTFLLYFCLDRFTVTVLIFVARAFISGAFQCAYVYTPEVYPTTLRAV 458
Cdd:pfam07690  42 SLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGR 121
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 32564663   459 GLGTCSAMARIGAIVTPFIAQVASekSLSLPIGIYGTAAILGLIASLSL 507
Cdd:pfam07690 122 ALGLVSAGFGLGAALGPLLGGLLA--SLFGWRAAFLILAILSLLAAVLL 168
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
377-505 1.84e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 43.81  E-value: 1.84e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 377 STTLAEFPGLIITVLIIEWFGRKKTMALEYAVFAIFTFLLYFCLDRFTVTVLIFVARAFISGAFQCAYVYTPEVYPTTLR 456
Cdd:COG2814  53 AYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERR 132
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 32564663 457 AVGLGTCSAMARIGAIVTPFIAQVASEK-SLSLPIGIYGTAAILGLIASL 505
Cdd:COG2814 133 GRALGLLGAGLGLGPALGPLLGGLLADLfGWRWVFLVNAVLALLALLLLL 182
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
61-257 3.97e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 42.92  E-value: 3.97e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  61 PDSEKTFTVDEAVEALGFGRFQLKLSILTGMAWMADAM-EMMLLSLISPALACEWGISSVQQALVTTCVFSGMMLSSTFW 139
Cdd:COG0738 187 PEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGaEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLG 266
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 140 GKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLLFFRGLTGFGIGGV-PQSVTLYAEFLPtAQRAKCVVLIESFWAI 218
Cdd:COG0738 267 GFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMfPTIFSLALDGLG-KRTAAAVSAVLIMGIV 345
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 32564663 219 GAVFEALLAYFVMESFGWRALMFLSSLPLGIFAVASFWL 257
Cdd:COG0738 346 GGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALAL 384
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
131-257 5.48e-04

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 42.22  E-value: 5.48e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 131 GMMLSSTFWGKI---------CDRFGRRKGLTFSTLVAcimGVISGMSP-----HFYVLLFFRGLTGFGIGGV-PQSVTL 195
Cdd:cd17318  59 GIILSSFFYGYIltqipggylAEKYGAKRVLGYSILIT---ALLTLLTPlaargGYGALIVLRILQGLAQGVTfPAMHAL 135
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 32564663 196 YAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFGWRALMFLSslplGIFAVASFWL 257
Cdd:cd17318 136 WAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIF----GGLGLLWCLL 193
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
97-260 5.75e-04

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 42.37  E-value: 5.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663    97 AMEMMLLSLisPALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLL 176
Cdd:TIGR00710  20 GIDMYLPAF--PEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLL 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   177 FFRGLTGFGI-GGVPQSVTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFGWRALMFLSSLpLGIFAVASF 255
Cdd:TIGR00710  98 VLRFVQAFGAsAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSL-AGILLSALI 176

                  ....*..
gi 32564663   256 W--LPES 260
Cdd:TIGR00710 177 FfiLPET 183
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
140-274 6.44e-04

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 42.21  E-value: 6.44e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 140 GKICDRFGRRK-----GLTFSTLVACIMGvisgMSPHFYVLLFFRGLTGFGIGG-VPQSVtLYAEFLPTAQRAKCVVLIE 213
Cdd:cd17490  52 GILSDRIGKRKlfiiiGLLFTVLASLIMI----LFPSPWGLLIARFLSGIAAATwVSFTV-LYASYFPPDEAAKAMGLIN 126
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 32564663 214 SFWAIGAVFEALLAYFVMESFGWRALMFLSSLPLGIFAVASFWLPESARFDMASGHPERAL 274
Cdd:cd17490 127 LVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERREKKPVLTELKEL 187
MFS_GLUT8_Class3 cd17433
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
131-463 7.25e-04

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340991 [Multi-domain]  Cd Length: 416  Bit Score: 42.17  E-value: 7.25e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 131 GMMLSSTFWGKICDRFGRRKGLTFSTlVACIMGVISGMSPH-FYVLLFFRGLTGFGIGGVPQSVTLY-AEFLPTAQRA-- 206
Cdd:cd17433  53 GAAAGGVLGGWIVDRAGRKLSLMLCS-VPFIAGFTVITAAQnVWMLYVGRLLTGLASGVTSLVVPVYiSEIAHPRVRGtl 131
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 207 -KCVVLIesfwaigAVFEALLAYFVMESFGWRALMFLSSLPLGIFAVASFWLPESARFDMASGHPERALETLQAAARMNR 285
Cdd:cd17433 132 gSCVQLM-------VVIGIMGAYLAGLVLDWRWLAVLGSIPPTLMLLLMCFMPETPRFLLTQHRRQEAMAALRFLRGPDQ 204
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 286 VQLPTGRLVSSTKAGSESRGDIANLLSPDLRKTTILLWCIWAITAFSYYGMVLF--TTVLFQSHdechgglFSNGTQMEV 363
Cdd:cd17433 205 GWEWECIGIEQSFHLEEQSFSLALLKQPGIYKPLIIGVSLMAFQQLTGINAVMFyaETIFEEAK-------FKDSSVASV 277
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 364 CQPLTRsdyfdLLSTTLAefpgliitVLIIEWFGRKKTMALEYAVFAIFTFLLYFcldrFTVTVLIFVARAFISGAFQCA 443
Cdd:cd17433 278 IVAAIQ-----VLFTAVA--------ALIMDRAGRKVLLVLSGVVMVFSTAAFGW----LAVGSMGFFIAGFAVGWGPIP 340
                       330       340
                ....*....|....*....|
gi 32564663 444 YVYTPEVYPTTLRAVGLGTC 463
Cdd:cd17433 341 WLVMSEIFPLHVRGVASGIC 360
MFS_SLC22A17 cd17445
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ...
127-250 9.45e-04

Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341003 [Multi-domain]  Cd Length: 346  Bit Score: 41.30  E-value: 9.45e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 127 CVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLLFFRGLTGFGIGGVPQSVTLYAEFLPTAQRA 206
Cdd:cd17445  44 CFILGFASGYLCLGYTADRLGRRRTLLLSLTLAVPFGVLVAVAASPSLFMAMRFLLGAALAGVYLTLYLTRLELCDPPQR 123
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 32564663 207 KCVVLIESFWAIGAVFeaLLAYFVMESFGWRALMFLSSLPLGIF 250
Cdd:cd17445 124 LLVAMAGGLTMVGGHF--LLLGLALGCGSWRVLQGTITAPLSLF 165
MFS_NRT2_like cd17341
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ...
101-255 1.40e-03

Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340899 [Multi-domain]  Cd Length: 384  Bit Score: 41.08  E-value: 1.40e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 101 MLLSLISPALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACI--MGVISGMSPhFYVLLFF 178
Cdd:cd17341  16 FLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIplLALALAVSS-YWGLLVL 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 179 RGLTGFGIGGVPQSVTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLA-------YFVMESFGWRALMFLSSLPLGIFA 251
Cdd:cd17341  95 GFLLGFAGANFASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLApliagaiVFDGGFVGWRNAFFVPGILLAIAA 174

                ....
gi 32564663 252 VASF 255
Cdd:cd17341 175 VLVL 178
MFS_ProP cd17366
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ...
138-252 1.44e-03

Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340924 [Multi-domain]  Cd Length: 377  Bit Score: 40.80  E-value: 1.44e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 138 FWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHF--------YVLLFFRGLTGFGIGGVPQSVTLY-AEFLPTAQRAKC 208
Cdd:cd17366  59 VFGPLGDKYGRQKVLAITIILMAASTFCIGLLPTYatigvwapILLLLARMVQGFSTGGEYGGAATFvAEYAPDRKRGFL 138
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 32564663 209 VVLIE----SFWAIGAVFEALLAYFV----MESFGWRaLMFLSSLPLGIFAV 252
Cdd:cd17366 139 GSWLEfgtlAGFILGAGLVTLLTLLLteaqMLDWGWR-IPFLIAAPLGLVGL 189
MFS_GLUT_Class1 cd17431
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
124-263 1.65e-03

Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340989 [Multi-domain]  Cd Length: 445  Bit Score: 40.78  E-value: 1.65e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 124 VTTCVFS-GMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSP--HFYVLL----FFRGL-TGFGIGGVPQSVTl 195
Cdd:cd17431  54 LSVAIFSvGGMIGSFSVGLFVNRFGRRNSMLYNNLLAFAGAALMGLSKlaKSYEMLilgrFIIGLyCGLTTGLVPMYIG- 132
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 32564663 196 yaEFLPTAQRAKCvvliESFWAIGAVFEALLA-YFVMESF-----GWRALMFLSSLPLGIFAVASFWLPESARF 263
Cdd:cd17431 133 --EISPTALRGAL----GTLHQLGIVVGILISqIFGLEFIlgteeLWPLLLGFTIVPAILQLALLPFCPESPRY 200
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
78-255 2.09e-03

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 40.61  E-value: 2.09e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  78 FGRFQLKLSILTGMAWMAdAMeMMLLSLISPALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTL 157
Cdd:cd17324 195 LRNPRLRLAYLITFLLFG-GF-FALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLL 272
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 158 VACIMGVISGMSPHFYVLLFFRGLTGFGIGGVPQSVTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFGWR 237
Cdd:cd17324 273 LAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWA 352
                       170
                ....*....|....*...
gi 32564663 238 ALMFLSSLPLGIFAVASF 255
Cdd:cd17324 353 GVGWVGAALLLLALLLAL 370
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
101-266 2.19e-03

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 40.29  E-value: 2.19e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 101 MLLSLISPaLACEWGISSVQQALVTTcVFSGMML-SSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLLFFR 179
Cdd:cd17390  14 MILPLLST-HIRSLGASPTVIGLIGS-VYGALQLfSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSR 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 180 GLTgfGIGGVPQSVT--LYAEFLPTAQRAKCVVLIESFWAIGAVFEALL-AYFVMESFGWR------ALMFLSSLPLGIF 250
Cdd:cd17390  92 IPL--GIFKHTQSLCkaYLSDLVSEQERSRVLGRFNAASSLGFILGPVVgGHLAETDGGFYyvallcSAIFILNAGLVWF 169
                       170
                ....*....|....*.
gi 32564663 251 AVASFWLPESARFDMA 266
Cdd:cd17390 170 LLSKLWDLLLVRFLMG 185
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
391-515 2.21e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 40.49  E-value: 2.21e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 391 LIIEWFGRKKTMALEYAVFAIFTFLLYFCLDRFTVTVLIFVARAFISGAFQCAYVYTPEVYPTTLRAVGLGTCSAMARIG 470
Cdd:cd06174  53 LLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVG 132
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 32564663 471 AIVTPFIAQV---ASEKSLSLPIGIYGTAAILGLIASLSLPIETKGRQ 515
Cdd:cd06174 133 GILGPLLGGIlasSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESA 180
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
97-260 2.59e-03

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 40.39  E-value: 2.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   97 AMEMMLLSLisPALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLL 176
Cdd:PRK10473  18 GIDMYLVGL--PRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFL 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  177 FFRGLTGFGIGGVpqSVTLYA---EFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFGWRALMF-LSSLPLGIFAV 252
Cdd:PRK10473  96 AGRFLQGIGAGCC--YVVAFAilrDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYtMAAMGILVLLL 173

                 ....*...
gi 32564663  253 ASFWLPES 260
Cdd:PRK10473 174 SLFILKET 181
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
115-255 2.93e-03

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 39.86  E-value: 2.93e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 115 GISSVQQALVTTCVFSGMMLSSTFWGKICDRF---GRRKGLTFSTLVACIMGVISGMSPHFYVLLFFRGLTGFGIG-GVP 190
Cdd:cd17319 211 GFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrgARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGaASP 290
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 32564663 191 QSVTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFG-WRALMFLSSLPLGIFAVASF 255
Cdd:cd17319 291 VFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGsYTAAFLFLAAVALLAALLVL 356
MFS_CitA cd17368
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ...
140-297 3.37e-03

Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340926 [Multi-domain]  Cd Length: 407  Bit Score: 40.05  E-value: 3.37e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 140 GKICDRFGRRKGLTFSTLVACIMGVISGMSPHF--------YVLLFFRGLTGFGIGGVPQSVTLY-AEFLPTAQRAKCVV 210
Cdd:cd17368  61 GAYADRIGRKPAMTLTLAIMALGTLLIALAPTYatigiaapLLVLLARLLQGFAAGGEVGGVTAYlVEAAPPGRRGFYTS 140
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 211 LIESFWAIGAVFEALLAYFV--------MESFGWRALMFLSSL--PLGIFAVASFWLPESARFDMASGHPERALETLQAA 280
Cdd:cd17368 141 WQSASQQVAIVAGALVGYLLsltltaeaLAEWGWRIPFFIGLLiiPLGLWLRRSLEETEAFLERKARPTRRELFALLANN 220
                       170
                ....*....|....*..
gi 32564663 281 ARMnrVQLPTGRLVSST 297
Cdd:cd17368 221 RRI--ILLGMLLVAGST 235
MFS_MFSD5_like cd17487
Major facilitator superfamily domain containing 5 protein; Human major facilitator superfamily ...
107-185 3.42e-03

Major facilitator superfamily domain containing 5 protein; Human major facilitator superfamily domain containing 5 protein (MFSD5) is also called molybdate-anion transporter, or molybdate transporter 2 homolog (MOT2). It acts as an atypical solute carrier (SLC) that mediates high-affinity intracellular uptake of the rare oligo-element molybdenum. It may also play a role in maintaining the glucose homeostasis and pancreatic beta-cell proliferation, as well as in altered energy homeostasis. MFSD5 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341040  Cd Length: 385  Bit Score: 39.89  E-value: 3.42e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 107 SPALACEW-------------GISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKG-LTFSTL--VACIMgvisGMSP 170
Cdd:cd17487  13 LLAMFADWlqgpylyalyesyGFSEEQIAILFVTGFGSSVVFGTFVGSLADKFGRKRAcLLFCVLysLSCLT----KHSP 88
                        90
                ....*....|....*
gi 32564663 171 HFYVLLFFRGLTGFG 185
Cdd:cd17487  89 NFGVLLLGRVLGGIS 103
2A0108 TIGR00886
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
100-258 3.58e-03

nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]


Pssm-ID: 273322 [Multi-domain]  Cd Length: 354  Bit Score: 39.59  E-value: 3.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   100 MMLLSLISPALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVA---CIMGVISGMSphFYVLL 176
Cdd:TIGR00886  18 FAFSPLAVFLIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLaipCLWAGLAVQS--YSVLL 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663   177 FFRGLTGFGIGGVPQSVTLYAEFLPTaqraKCVVLIESFWAIGAVFEALLAYFVM----------------ESFGWRALM 240
Cdd:TIGR00886  96 LIRLFIGIAGGSFASCMPWISFFFPK----KIQGTALGLAAGWGNMGGGVAQFVMppiigslifgggqpahLAWGWAFVI 171
                         170       180
                  ....*....|....*....|..
gi 32564663   241 FLSSLP----LGIFAVASFWLP 258
Cdd:TIGR00886 172 VPAGILllpaLLIFFVGADTPP 193
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
138-505 3.82e-03

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 39.82  E-value: 3.82e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 138 FWGKICDRFGRRKgltfsTLVACI--MGVIS---GMSPHF--------YVLLFFRGLTGFGIGG-VPQSVTLYAEFLPTA 203
Cdd:cd17369  63 VFGHFGDRIGRKK-----TLVLTLllMGIATfliGLLPTYaqigilapILLVLLRLLQGLALGGeWGGAVLMAVEHAPPK 137
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 204 QRAkcvvLIESFWAIGAVFEALLAYFV------------MESFGWRaLMFLSSLPLGIFAVasfW----LPESARFdmas 267
Cdd:cd17369 138 RRG----FYGSFPQLGAPVGLLLATGVflllsallsdeaFLSWGWR-IPFLLSAVLVAVGL---YirlrLEETPVF---- 205
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 268 ghpERALETLQAAARmnrvqlptgrlvsstkagsesrgDIANLLSPDLRKTTILLWCIWAITAFSY----YGMVLFTTVL 343
Cdd:cd17369 206 ---RRAKEAGQVVRA-----------------------PLVEVLRRHWRALLLAIGLRLAENVLFYlfttFALSYATQTL 259
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 344 fqshdechgglfsngtqmevcqPLTRSDYfdLLSTTLAEFPGLIITVLIIEW---FGRKKTMALEYAVFAIFTFLLYFCL 420
Cdd:cd17369 260 ----------------------GVDRSTV--LLAVLIASVVAAITIPLFGWLsdrVGRRPVYLAGALLAALFAFPFFWLL 315
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 421 DrFTVTVLIFVARAFISGAFQCAY-----VYTPEVYPTTLR--AVGLGTCSAmARIGAIVTPFIAQVASEKSLS-LPIGI 492
Cdd:cd17369 316 D-TGSTWLIVLAAVVVLGVLHGMMygpqaAFLAELFPTRVRytGASLGYQLG-AILGGGFAPLIATALVAATGSwWPVAL 393
                       410
                ....*....|....
gi 32564663 493 Y-GTAAILGLIASL 505
Cdd:cd17369 394 YlAALAVISLVAAL 407
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
138-256 4.01e-03

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 39.55  E-value: 4.01e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 138 FWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLLFFRGLTGFGIGG-VPQSVTLYAEFLPTAQRAKCVVLIESFW 216
Cdd:cd17476  52 IFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLGPAFlLPNAMALLGRTYPPGPRKNIVFSLFGAT 131
                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 32564663 217 A-IGAVFEALLAYFVMESFGWRALMFLSSLPLGIFAVASFW 256
Cdd:cd17476 132 ApLGFALGGVFGGLFAQLAWWPWIFWFLAILAAIVAVAAIF 172
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
101-189 4.14e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 39.46  E-value: 4.14e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 101 MLLSLISPALAcEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVLLFFRG 180
Cdd:cd17477  14 LLLPLLSLRLE-REGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRF 92

                ....*....
gi 32564663 181 LTGFGIGGV 189
Cdd:cd17477  93 VMGIGLAGL 101
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
131-257 4.87e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 39.48  E-value: 4.87e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 131 GMMLSSTFWGKICD-RFGRRKGLTFSTLVACIMGVISGMSPHFYVLLFFRGLTGFGIGGVPQSV-TLYAEFLPTAQRAKC 208
Cdd:cd17474 246 LLALGSLFVGRLLKkRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLtTLVTELAPEEERGTA 325
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 32564663 209 VVLIESFWAIGAVFEALLAYFVMESFGWRALMFLsslpLGIFAVASFWL 257
Cdd:cd17474 326 SSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLV----GAAIALAAAVL 370
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
117-509 5.91e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 39.14  E-value: 5.91e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 117 SSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTL---VACIMGVISGMSPHFYVLLFFRGLTGFGIGGVPQSV 193
Cdd:cd06173  32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLlraLLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGP 111
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 194 TLYA---EFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFGWRALMFLSSLPLGIFAVASFWLpesaRFDMASGHP 270
Cdd:cd06173 112 ARQAllpELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFI----RRPPPAAPG 187
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 271 ERALETLQAAARMNRVqlptgrlvsstkagsesrgdiaNLLSPDLRKTTILLWCIWAITAFSYYGMVLFTTVLFqshdec 350
Cdd:cd06173 188 ESSSLLLRDLREGLRY----------------------LRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVL------ 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 351 HGGLFSNGTqMEVCQPLtrsdyfdllsttlaefpGLIITVLIIEWFGRK----KTMALEYAVFAIFTFLLYFcLDRFTVT 426
Cdd:cd06173 240 GGGAAGYGL-LLAAFGV-----------------GALLGALLLGRLSKRrrrgRLLLIGALLLGLALLVLGL-SPSLWLL 300
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 427 VLIFVARAFISGAFQ-CAYVYTPEVYPTTLRAVGLGTCSAMARIGAIVTPFIAQVASEKsLSLPIGIYGTAAILGLIASL 505
Cdd:cd06173 301 LAALFLLGLAGGLFNvPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADA-LGLSAVFLLAGALLLLAALL 379

                ....
gi 32564663 506 SLPI 509
Cdd:cd06173 380 LLLL 383
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
85-285 6.56e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 38.75  E-value: 6.56e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663  85 LSILTGMAWMADAMEMMLLSLispALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGV 164
Cdd:cd17329   4 LLIGSFLNRLGFFMVWPFMAI---YLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 165 ISGMSPHFYVLLFFRGLTGFGiGGV--PQSVTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLA-YFVMESFGWrALMF 241
Cdd:cd17329  81 LLGFAHSPWLFAIALVLTGFG-GGLfePASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGgLLLLYSFRL-LFLA 158
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 32564663 242 LSSLPLGIFAVASFWLPESarfdMASGHPERALETLQAAARMNR 285
Cdd:cd17329 159 AAVLFLLAALVLLFLLPET----RPKRRAAEKTEILRGYKIVLR 198
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
104-205 6.70e-03

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 38.75  E-value: 6.70e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 104 SLISPAL--ACEWGISSVQQALVTTCVFSGMMLSstFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHF-YVLLFFRG 180
Cdd:cd17353  23 SVFNPPLssALGWSLASVALAFTLTIVFLAISAP--FAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLpLLFLGYGV 100
                        90       100
                ....*....|....*....|....*
gi 32564663 181 LTGFGIGgvpqsvTLYAEFLPTAQR 205
Cdd:cd17353 101 LGGIGAG------IGYITPVSTAVK 119
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
108-256 8.04e-03

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 38.79  E-value: 8.04e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 108 PALACEWGISSVQQALVTTCVFSGMMLSSTFWGKICDRFGRRKGLTFSTLVACIMGVISGMSPH-FYVLLFFRGLTGFGI 186
Cdd:cd17355 234 VPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFpPLALLLFAALFGLGW 313
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 32564663 187 GG-VPQSVTLYAEFLPTAQRAKCVVLIESFWAIGAVFEALLAYFVMESFGWRALMFLSSLPLGIFAVASFW 256
Cdd:cd17355 314 GAtVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVL 384
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
138-257 9.50e-03

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 38.36  E-value: 9.50e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564663 138 FWGKICDRFGRRKGLTFSTLVACIMGVISGMSPHFYVL-LFFRGLTGFGIGGvpqSVTLYAEFLP----TAQRAKCVVLI 212
Cdd:cd17353 268 FWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVLfVLGVALIGFCYGG---GFALFPALTAdffgTKNAGTNYGLL 344
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 32564663 213 ESFWAIGAVFEALLAYFVMESFGWRALMFLSSLPLGIFAVASFWL 257
Cdd:cd17353 345 YTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALALLL 389
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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