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Conserved domains on  [gi|25151362|ref|NP_498631|]
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Protein WBSCR14 homolog [Caenorhabditis elegans]

Protein Classification

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List of domain hits

 Name Accession Description Interval E-value
NES2-NLS_ChREBP-like cd21739
nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in ...
 74-189 1.88e-54

nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in carbohydrate-responsive element-binding protein (ChREBP), MLX-interacting protein (MLXIP), and similar proteins; This family includes two transcription factors: ChREBP and MLXIP. ChREBP, also called class D basic helix-loop-helix protein 14 (bHLHd14), Max-like protein (MLX) interactor or MIO, MLX-interacting protein-like (MLXIPL), WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), functions at two levels; nuclear localization and DNA binding. ChREBP binds to the canonical and non-canonical E box sequences 5'-CACGTG-3'. It also binds DNA as a heterodimer with TCFL4/MLX. MLXIP, also called class E basic helix-loop-helix protein 36 (bHLHe36), transcriptional activator MondoA, or MIR, is a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network. MLXIP binds DNA by forming a heterodimer with Max-like protein (MLX), and activates transcription. It binds to the canonical E box sequence 5'-CACGTG-3'. MLXIP plays a role in transcriptional activation of glycolytic target genes and is involved in glucose-responsive gene regulation. Members in this family may contain functional domains, including two nuclear export signals, NES1 and NES2, and a nuclear import signal (NLS) in the N-terminal region. This model corresponds to NES2 and NLS domains.


:

Pssm-ID: 439286  Cd Length: 113  Bit Score: 184.39  E-value: 1.88e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25151362   74 AIDVSLNKLNKCIKVAY-NKMTTPKWKDFKGLRLHWKQRVRLNNVIWRAYYIEFRkkqpEKPKKPFCYFAVPDDDTTHQK 152
Cdd:cd21739    1 AIDESLTKLFKCLTLAYsGKLTSPKWKNFKGLKLRWKDKIRLNNAIWREWHMQFV----KKKKPPVCQFAVPLDDDTHKK 76

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 25151362  153 IEGSIVEGMYWKRKMEGVCAQYKRWRIRSKHNLVTDK 189
Cdd:cd21739   77 PEAVVLEGKYWKRRLETVVREYKKWRLFYKDKLAGKT 113
bHLHzip_Mlx_like cd11404
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) family; Mlx, ...
 803-874 4.28e-24

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) family; Mlx, also termed Class D basic helix-loop-helix protein 13 (bHLHd13), or Max-like bHLHZip protein, or protein BigMax, or transcription factor-like protein 4, is a Max-like bHLHZip transcription regulator that interacts with the Max network of transcription factors. It forms a sequence-specific DNA-binding protein complex with some member of Mad family (Mad1 and Mad4) and Mondo family but not the Myc family and bind the E-box DNA to control transcription. The family also includes Saccharomyces cerevisiae INO4, which is a bHLH transcriptional activator of phospholipid synthetic genes (such as INO1, CHO1/PSS, CHO2/PEM1, OPI3/PEM2, etc.). It is required for de-repression of phospholipid biosynthetic gene expression in response to inositol deprivation in yeast.


:

Pssm-ID: 381410 [Multi-domain]  Cd Length: 70  Bit Score: 96.21  E-value: 4.28e-24
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 25151362  803 RKRILHLHAEQNRRSALKDGFDQLMDIIPDLYSggVKPTNAVVLAKSADHIRRLQAEKWDKTQKIDEAKAKI 874
Cdd:cd11404    1 QRRLNHVRSEKKRRELIKKGYDELCALVPGLDP--QKRTKADILQKAADWIQELKEENEKLEEQLDELKEAA 70
 
Name Accession Description Interval E-value
NES2-NLS_ChREBP-like cd21739
nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in ...
 74-189 1.88e-54

nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in carbohydrate-responsive element-binding protein (ChREBP), MLX-interacting protein (MLXIP), and similar proteins; This family includes two transcription factors: ChREBP and MLXIP. ChREBP, also called class D basic helix-loop-helix protein 14 (bHLHd14), Max-like protein (MLX) interactor or MIO, MLX-interacting protein-like (MLXIPL), WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), functions at two levels; nuclear localization and DNA binding. ChREBP binds to the canonical and non-canonical E box sequences 5'-CACGTG-3'. It also binds DNA as a heterodimer with TCFL4/MLX. MLXIP, also called class E basic helix-loop-helix protein 36 (bHLHe36), transcriptional activator MondoA, or MIR, is a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network. MLXIP binds DNA by forming a heterodimer with Max-like protein (MLX), and activates transcription. It binds to the canonical E box sequence 5'-CACGTG-3'. MLXIP plays a role in transcriptional activation of glycolytic target genes and is involved in glucose-responsive gene regulation. Members in this family may contain functional domains, including two nuclear export signals, NES1 and NES2, and a nuclear import signal (NLS) in the N-terminal region. This model corresponds to NES2 and NLS domains.


Pssm-ID: 439286  Cd Length: 113  Bit Score: 184.39  E-value: 1.88e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25151362   74 AIDVSLNKLNKCIKVAY-NKMTTPKWKDFKGLRLHWKQRVRLNNVIWRAYYIEFRkkqpEKPKKPFCYFAVPDDDTTHQK 152
Cdd:cd21739    1 AIDESLTKLFKCLTLAYsGKLTSPKWKNFKGLKLRWKDKIRLNNAIWREWHMQFV----KKKKPPVCQFAVPLDDDTHKK 76

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 25151362  153 IEGSIVEGMYWKRKMEGVCAQYKRWRIRSKHNLVTDK 189
Cdd:cd21739   77 PEAVVLEGKYWKRRLETVVREYKKWRLFYKDKLAGKT 113
bHLHzip_Mlx_like cd11404
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) family; Mlx, ...
 803-874 4.28e-24

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) family; Mlx, also termed Class D basic helix-loop-helix protein 13 (bHLHd13), or Max-like bHLHZip protein, or protein BigMax, or transcription factor-like protein 4, is a Max-like bHLHZip transcription regulator that interacts with the Max network of transcription factors. It forms a sequence-specific DNA-binding protein complex with some member of Mad family (Mad1 and Mad4) and Mondo family but not the Myc family and bind the E-box DNA to control transcription. The family also includes Saccharomyces cerevisiae INO4, which is a bHLH transcriptional activator of phospholipid synthetic genes (such as INO1, CHO1/PSS, CHO2/PEM1, OPI3/PEM2, etc.). It is required for de-repression of phospholipid biosynthetic gene expression in response to inositol deprivation in yeast.


Pssm-ID: 381410 [Multi-domain]  Cd Length: 70  Bit Score: 96.21  E-value: 4.28e-24
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 25151362  803 RKRILHLHAEQNRRSALKDGFDQLMDIIPDLYSggVKPTNAVVLAKSADHIRRLQAEKWDKTQKIDEAKAKI 874
Cdd:cd11404    1 QRRLNHVRSEKKRRELIKKGYDELCALVPGLDP--QKRTKADILQKAADWIQELKEENEKLEEQLDELKEAA 70
HLH pfam00010
Helix-loop-helix DNA-binding domain;
804-857 2.50e-08

Helix-loop-helix DNA-binding domain;


Pssm-ID: 459628 [Multi-domain]  Cd Length: 53  Bit Score: 50.92  E-value: 2.50e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 25151362    804 KRILHLHAEQNRRSALKDGFDQLMDIIPDLYSGGvKPTNAVVLAKSADHIRRLQ 857
Cdd:pfam00010    1 RREAHNERERRRRDRINDAFDELRELLPTLPPDK-KLSKAEILRLAIEYIKHLQ 53
HLH smart00353
helix loop helix domain;
811-859 2.29e-07

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 48.37  E-value: 2.29e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 25151362     811 AEQNRRSALKDGFDQLMDIIPDLYSgGVKPTNAVVLAKSADHIRRLQAE 859
Cdd:smart00353    3 RERRRRRKINEAFDELRSLLPTLPK-NKKLSKAEILRLAIEYIKSLQEE 50
 
Name Accession Description Interval E-value
NES2-NLS_ChREBP-like cd21739
nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in ...
 74-189 1.88e-54

nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in carbohydrate-responsive element-binding protein (ChREBP), MLX-interacting protein (MLXIP), and similar proteins; This family includes two transcription factors: ChREBP and MLXIP. ChREBP, also called class D basic helix-loop-helix protein 14 (bHLHd14), Max-like protein (MLX) interactor or MIO, MLX-interacting protein-like (MLXIPL), WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), functions at two levels; nuclear localization and DNA binding. ChREBP binds to the canonical and non-canonical E box sequences 5'-CACGTG-3'. It also binds DNA as a heterodimer with TCFL4/MLX. MLXIP, also called class E basic helix-loop-helix protein 36 (bHLHe36), transcriptional activator MondoA, or MIR, is a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network. MLXIP binds DNA by forming a heterodimer with Max-like protein (MLX), and activates transcription. It binds to the canonical E box sequence 5'-CACGTG-3'. MLXIP plays a role in transcriptional activation of glycolytic target genes and is involved in glucose-responsive gene regulation. Members in this family may contain functional domains, including two nuclear export signals, NES1 and NES2, and a nuclear import signal (NLS) in the N-terminal region. This model corresponds to NES2 and NLS domains.


Pssm-ID: 439286  Cd Length: 113  Bit Score: 184.39  E-value: 1.88e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25151362   74 AIDVSLNKLNKCIKVAY-NKMTTPKWKDFKGLRLHWKQRVRLNNVIWRAYYIEFRkkqpEKPKKPFCYFAVPDDDTTHQK 152
Cdd:cd21739    1 AIDESLTKLFKCLTLAYsGKLTSPKWKNFKGLKLRWKDKIRLNNAIWREWHMQFV----KKKKPPVCQFAVPLDDDTHKK 76

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 25151362  153 IEGSIVEGMYWKRKMEGVCAQYKRWRIRSKHNLVTDK 189
Cdd:cd21739   77 PEAVVLEGKYWKRRLETVVREYKKWRLFYKDKLAGKT 113
NES2-NLS_ChREBP cd21771
nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in ...
 74-185 3.33e-29

nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in carbohydrate-responsive element-binding protein (ChREBP), and similar proteins; ChREBP, also called class D basic helix-loop-helix protein 14 (bHLHd14), Max-like protein (MLX) interactor or MIO, MLX-interacting protein-like (MLXIPL), WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), is a large transcription factor that functions at two levels, nuclear localization and DNA binding. It binds to the canonical and non-canonical E box sequences 5'-CACGTG-3'. It also binds DNA as a heterodimer with TCFL4/MLX. ChREBP contains functional domains, including two nuclear export signals, NES1 and NES2, and a nuclear import signal (NLS) in the N-terminal region. This model corresponds to NES2 and NLS domains.


Pssm-ID: 439287  Cd Length: 116  Bit Score: 112.76  E-value: 3.33e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25151362   74 AIDVSLNKLNKCIKVAYN-KMTTPKWKDFKGLRLHWKQRVRLNNVIWRAYYIEFrkkqPEKPKKPFCYFAVP---DDDTT 149
Cdd:cd21771    1 SIDPTLTRLFECMSLAYSgKLVSPKWKNFKGLRLLWRDKIRLNNAIWRAWYIQY----VEKRKNPVCGFVTPlegSEADE 76

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 25151362  150 HQKIEGSIVEGMYWKRKMEGVCAQYKRWRIRSKHNL 185
Cdd:cd21771   77 HRKPEAVVLEGNYWKRRIEVVMKEYHKWRIYYKKRL 112
NES2-NLS_MLXIP cd21772
nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in ...
 74-189 5.85e-29

nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in MLX-interacting protein (MLXIP), and similar proteins; MLXIP, also called class E basic helix-loop-helix protein 36 (bHLHe36), transcriptional activator MondoA, or MIR, is a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network. It binds DNA by forming a heterodimer with Max-like protein (MLX) and activates transcription. It binds to the canonical E box sequence 5'-CACGTG-3'. MLXIP plays a role in transcriptional activation of glycolytic target genes and is involved in glucose-responsive gene regulation. MLXIP may contain functional domains, including two nuclear export signals, NES1 and NES2, and a nuclear import signal (NLS) in the N-terminal region. This model corresponds to NES2 and NLS domains.


Pssm-ID: 439288  Cd Length: 117  Bit Score: 112.07  E-value: 5.85e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25151362   74 AIDVSLNKLNKCIKVAYN-KMTTPKWKDFKGLRLHWKQRVRLNNVIWRAYYIEFrkkqPEKPKKPFCYFAVPDDDTT--- 149
Cdd:cd21772    1 SIDASLTKLFECMTLAYSgKLVSPKWKNFKGLKLQWRDKIRLNNAIWRAWYMQY----LEKRKNPVCHFVTPLDGSVdvd 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 25151362  150 -HQKIEGSIVEGMYWKRKMEGVCAQYKRWRIRSKHNLVTDK 189
Cdd:cd21772   77 eHRRPEAIATEGKYWKRRIEIVIREYHKWRTYFKKRLQKHK 117
bHLHzip_Mlx_like cd11404
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) family; Mlx, ...
 803-874 4.28e-24

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) family; Mlx, also termed Class D basic helix-loop-helix protein 13 (bHLHd13), or Max-like bHLHZip protein, or protein BigMax, or transcription factor-like protein 4, is a Max-like bHLHZip transcription regulator that interacts with the Max network of transcription factors. It forms a sequence-specific DNA-binding protein complex with some member of Mad family (Mad1 and Mad4) and Mondo family but not the Myc family and bind the E-box DNA to control transcription. The family also includes Saccharomyces cerevisiae INO4, which is a bHLH transcriptional activator of phospholipid synthetic genes (such as INO1, CHO1/PSS, CHO2/PEM1, OPI3/PEM2, etc.). It is required for de-repression of phospholipid biosynthetic gene expression in response to inositol deprivation in yeast.


Pssm-ID: 381410 [Multi-domain]  Cd Length: 70  Bit Score: 96.21  E-value: 4.28e-24
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 25151362  803 RKRILHLHAEQNRRSALKDGFDQLMDIIPDLYSggVKPTNAVVLAKSADHIRRLQAEKWDKTQKIDEAKAKI 874
Cdd:cd11404    1 QRRLNHVRSEKKRRELIKKGYDELCALVPGLDP--QKRTKADILQKAADWIQELKEENEKLEEQLDELKEAA 70
bHLHzip_MLXIP_like cd11405
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP), ...
 802-881 2.86e-15

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP), MLX-interacting protein-like (MLXIPL) and similar proteins; The family includes MLXIP and MLXIPL. MLXIP, also termed Class E basic helix-loop-helix protein 36 (bHLHe36), or transcriptional activator MondoA, is a bHLHZip transcriptional activator that binds DNA as a heterodimer with Mlx. It binds to the canonical E box sequence 5'-CACGTG-3' and plays a role in transcriptional activation of glycolytic target genes. MLXIP is most highly expressed in skeletal muscle and functions as an indirect glucose sensor, by sensing glucose 6-phosphate and shuttling between the nucleus and the cytoplasm. MLXIPL, also termed carbohydrate-responsive element-binding protein (ChREBP), or Class D basic helix-loop-helix protein 14 (bHLHd14), or MLX interactor, or WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), is a bHLHZip transcriptional factor integral to the regulation of glycolysis and lipogenesis in the liver. It forms heterodimers with the bHLHZip protein Mlx to bind the DNA sequence 5'-CACGTG-3'.


Pssm-ID: 381411 [Multi-domain]  Cd Length: 74  Bit Score: 71.54  E-value: 2.86e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25151362  802 ERKRILHLHAEQNRRSALKDGFDQLMDIIPDLYSGG-VKPTNAVVLAKSADHIRRLQAEKwdktqkiDEAKAKIEKLNQK 880
Cdd:cd11405    1 EQRRLSHISAEQKRRFNIKSGFDTLQSLIPSLGQNPnQKVSKAAMLQKAAEYIKSLKRER-------QQMQEEAEQLRQE 73


                 .
gi 25151362  881 I 881
Cdd:cd11405   74 I 74
bHLHzip_Mlx cd19687
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) and similar ...
 803-860 6.64e-11

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) and similar proteins; Mlx, also termed Class D basic helix-loop-helix protein 13 (bHLHd13), or Max-like bHLHZip protein, or protein BigMax, or transcription factor-like protein 4, is a Max-like bHLHZip transcription regulator that interacts with the Max network of transcription factors. It forms a sequence-specific DNA-binding protein complex with some member of Mad family (Mad1 and Mad4) and Mondo family but not the Myc family and bind the E-box DNA to control transcription.


Pssm-ID: 381530 [Multi-domain]  Cd Length: 76  Bit Score: 58.97  E-value: 6.64e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 25151362  803 RKRILHLHAEQNRRSALKDGFDQLMDIIPDL----YSGGVKPTNAVVLAKSADHIRRLQAEK 860
Cdd:cd19687    1 RRREAHTQAEQKRRDAIKKGYDDLQDIVPTCqqqdDIGSQKLSKATILQRSIDYIQFLHQQK 62
bHLHzip_Myc cd11400
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the Myc family; The Myc family is a ...
 804-884 9.00e-09

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the Myc family; The Myc family is a member of the bHLHzip family of transcription factors that play important roles in the control of normal cell proliferation, growth, survival and differentiation. All Myc isoforms contain two independently functioning polypeptide chain regions: N-terminal transactivating residues and a C-terminal bHLHzip segment. The bHLHzip family of bHLH transcription factors are characterized by a highly conserved N-terminal basic region that may bind DNA at a consensus hexanucleotide sequence known as the E-box (CANNTG) followed by HLH and leucine zipper motifs that may interact with other proteins to form homo- and heterodimers. Myc heterodimerizes with Max enabling specific binding to E-box DNA sequences in the promoters of target genes. The Myc proto-oncoprotein family includes at least five different functional members: c-, N-, L-, S- and B-Myc (which is lacking the bHLH domain).


Pssm-ID: 381406 [Multi-domain]  Cd Length: 80  Bit Score: 53.32  E-value: 9.00e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25151362  804 KRILHLHAEQNRRSALKDGFDQLMDIIPDLYSGGvKPTNAVVLAKSADHIRRLQAEKWDKTQKIDEAKAKIEKLNQKITS 883
Cdd:cd11400    1 KRRLHNVLERQRRNDLKNSFEKLRDLVPELADNE-KASKVVILKKATEYIKQLQQEEKKLEKEKDKLKARNEQLRKKLER 79


                 .
gi 25151362  884 L 884
Cdd:cd11400   80 L 80
HLH pfam00010
Helix-loop-helix DNA-binding domain;
804-857 2.50e-08

Helix-loop-helix DNA-binding domain;


Pssm-ID: 459628 [Multi-domain]  Cd Length: 53  Bit Score: 50.92  E-value: 2.50e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 25151362    804 KRILHLHAEQNRRSALKDGFDQLMDIIPDLYSGGvKPTNAVVLAKSADHIRRLQ 857
Cdd:pfam00010    1 RREAHNERERRRRDRINDAFDELRELLPTLPPDK-KLSKAEILRLAIEYIKHLQ 53
bHLH_SF cd00083
basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators ...
 812-858 9.31e-08

basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators that are found in organisms from yeast to humans. Members of the bHLH superfamily have two highly conserved and functionally distinct regions. The basic part is at the amino end of the bHLH that may bind DNA to a consensus hexanucleotide sequence known as the E box (CANNTG). Different families of bHLH proteins recognize different E-box consensus sequences. At the carboxyl-terminal end of the region is the HLH region that interacts with other proteins to form homo- and heterodimers. bHLH proteins function as a diverse set of regulatory factors because they recognize different DNA sequences and dimerize with different proteins. The bHLH proteins can be divided to cell-type specific and widely expressed proteins. The cell-type specific members of bHLH superfamily are involved in cell-fate determination and act in neurogenesis, cardiogenesis, myogenesis, and hematopoiesis.


Pssm-ID: 381392 [Multi-domain]  Cd Length: 46  Bit Score: 49.06  E-value: 9.31e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 25151362  812 EQNRRSALKDGFDQLMDIIPDLySGGVKPTNAVVLAKSADHIRRLQA 858
Cdd:cd00083    1 ERRRRDKINDAFEELKRLLPEL-PDSKKLSKASILQKAVEYIRELQS 46
bHLH_scINO4_like cd11403
basic Helix-Loop-Helix (bHLH) domain found in Saccharomyces cerevisiae INO4 and similar ...
 804-860 1.03e-07

basic Helix-Loop-Helix (bHLH) domain found in Saccharomyces cerevisiae INO4 and similar proteins; INO4 is a bHLH transcriptional activator of phospholipid synthetic genes (such as INO1, CHO1/PSS, CHO2/PEM1, OPI3/PEM2, etc.). It is required for de-repression of phospholipid biosynthetic gene expression in response to inositol deprivation in yeast. INO4 dimerizes with INO2 and binds to an UAS DNA element to control expression of the genes whose expression is inositol-responsive.


Pssm-ID: 381409  Cd Length: 71  Bit Score: 49.77  E-value: 1.03e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 25151362  804 KRILHLHAEQNRRSALKDGFDQLMDIIPDLYSGGVKpTNAVVLAKSADHIRRLQAEK 860
Cdd:cd11403    2 KKENHISSEHKRREAIREGFDRLCAIVPALSSSQSR-SEAVVYVKTVEYLKELYERR 57
HLH smart00353
helix loop helix domain;
811-859 2.29e-07

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 48.37  E-value: 2.29e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 25151362     811 AEQNRRSALKDGFDQLMDIIPDLYSgGVKPTNAVVLAKSADHIRRLQAE 859
Cdd:smart00353    3 RERRRRRKINEAFDELRSLLPTLPK-NKKLSKAEILRLAIEYIKSLQEE 50
bHLHzip_MLXIP cd19688
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP) and ...
 804-871 3.51e-07

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP) and similar proteins; MLXIP, also termed Class E basic helix-loop-helix protein 36 (bHLHe36), or transcriptional activator MondoA, is a bHLHZip transcriptional activator that binds DNA as a heterodimer with Mlx. It binds to the canonical E box sequence 5'-CACGTG-3' and plays a role in transcriptional activation of glycolytic target genes. MLXIP is most highly expressed in skeletal muscle and functions as an indirect glucose sensor, by sensing glucose 6-phosphate and shuttling between the nucleus and the cytoplasm.


Pssm-ID: 381531  Cd Length: 72  Bit Score: 48.41  E-value: 3.51e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 25151362  804 KRILHLHAEQNRRSALKDGFDQLMDIIPDLYSGgvKPT-NAVVLAKSADHIRRLQAEkwdKTQKIDEAK 871
Cdd:cd19688    3 RRMKHISAEQKRRFNIKICFDTLNSLVSTLKNS--KPIsNAITLQKTVEYIAKLQQE---RTQMQEETK 66
bHLHzip_Max cd11406
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in protein Max and similar proteins; Max, ...
 804-871 7.63e-07

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in protein Max and similar proteins; Max, also termed Class D basic helix-loop-helix protein 4 (bHLHd4), or Myc-associated factor X, is a bHLHZip transcription regulator that forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a transcriptional repressor. Max homodimer bind DNA but is transcriptionally inactive. Targeted deletion of max results in early embryonic lethality in mice.


Pssm-ID: 381412  Cd Length: 69  Bit Score: 47.35  E-value: 7.63e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 25151362  804 KRILHLHAEQNRRSALKDGFDQLMDIIPDLysGGVKPTNAVVLAKSADHIRRLQAEKWDKTQKIDEAK 871
Cdd:cd11406    1 KRAHHNALERKRRDHIKDSFHSLRDSVPSL--QGEKASRAQILKKATEYIQYMRRKNHTHQQDIDDLK 66
bHLH_ScINO2_like cd11388
basic helix-loop-helix (bHLH) domain found in Saccharomyces cerevisiae protein INO2 and ...
 802-867 1.69e-06

basic helix-loop-helix (bHLH) domain found in Saccharomyces cerevisiae protein INO2 and similar proteins; INO2 is a positive regulatory factor required for depression of the co-regulated phospholipid biosynthetic enzymes in Saccharomyces cerevisiae. It is also involved in the expression of ITR1.


Pssm-ID: 381394  Cd Length: 68  Bit Score: 46.19  E-value: 1.69e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 25151362  802 ERKRILHLHAEQNRRSALKDGFDQLMDIIPD-LYSGGVKPTNAVVLAKSADHIRRLQaEKWDKTQKI 867
Cdd:cd11388    1 PVKKWKHVEAEKKRRNQIKKGFEDLINLINYpRNNNEKRISKSELLNKAVDDIRGLL-KANEQLQEE 66
bHLHzip_MLXIPL cd19689
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein-like (MLXIPL) ...
 802-860 2.18e-06

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein-like (MLXIPL) and similar proteins; MLXIPL, also termed carbohydrate-responsive element-binding protein (ChREBP), or Class D basic helix-loop-helix protein 14 (bHLHd14), or MLX interactor, or WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), is a bHLHZip transcriptional factor integral to the regulation of glycolysis and lipogenesis in the liver. It forms heterodimers with the bHLHZip protein Mlx to bind the DNA sequence 5'-CACGTG-3'.


Pssm-ID: 381532  Cd Length: 76  Bit Score: 46.50  E-value: 2.18e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 25151362  802 ERKRILHLHAEQNRRSALKDGFDQLMDIIPDLYSG-GVKPTNAVVLAKSADHIRRLQAEK 860
Cdd:cd19689    3 ETRRITHISAEQKRRFNIKLGFDTLHSLVTTLSSQpSIKISKATTLQKTAEYISKLQQER 62
bHLHzip_spESC1_like cd19690
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Schizosaccharomyces pombe ESC1 (spESC1) ...
 805-859 1.08e-05

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Schizosaccharomyces pombe ESC1 (spESC1) and similar proteins; spESC1 is a bHLHzip protein with homology to human MyoD and Myf-5 myogenic differentiation inducers. It is involved in the sexual differentiation process.


Pssm-ID: 381533  Cd Length: 65  Bit Score: 43.99  E-value: 1.08e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 25151362  805 RILHLHAEQNRRSALKDGFDQLMDIIPDlySGGVKPTNAVVLAKSADHIRRLQAE 859
Cdd:cd19690    1 RVSHKLAERKRRKEMKELFEDLRDALPQ--ERGTKASKWEILTKAISYIQQLKRH 53
bHLHzip_c-Myc cd11458
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in c-Myc and similar proteins; c-Myc, ...
 801-884 4.57e-05

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in c-Myc and similar proteins; c-Myc, also termed Myc proto-oncogene protein, or Class E basic helix-loop-helix protein 39 (bHLHe39), or transcription factor p64, a bHLHZip proto-oncogene protein that functions as a transcription factor, which binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. It activates the transcription of growth-related genes.


Pssm-ID: 381464 [Multi-domain]  Cd Length: 84  Bit Score: 42.95  E-value: 4.57e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25151362  801 EERKRILHLHAEQNRRSALKDGFDQLMDIIPDLYSGGvKPTNAVVLAKSADHIRRLQAEKWDKTQKIDEAKAKIEKLNQK 880
Cdd:cd11458    2 ENDKRRTHNVLERQRRNELKLSFFALRDQIPEVANNE-KAPKVVILKKATEYILSMQADEQRLISEKEQLRRRREQLKHR 80


                 ....
gi 25151362  881 ITSL 884
Cdd:cd11458   81 LEQL 84
bHLHzip_USF2 cd18923
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in upstream stimulatory factor 2 (USF2) ...
 801-877 9.37e-05

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in upstream stimulatory factor 2 (USF2) and similar proteins; USF2, also termed Class B basic helix-loop-helix protein 12 (bHLHb12), or major late transcription factor 2, or FOS-interacting protein (FIP), or upstream transcription factor 2, is a bHLHzip transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.


Pssm-ID: 381493  Cd Length: 80  Bit Score: 41.99  E-value: 9.37e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 25151362  801 EERKRILHLHAEQNRRSALKDGFDQLMDIIPDLYSGGVK--PTNAVVLAKSADHIRRLQaekwDKTQKIDEAKAKIEKL 877
Cdd:cd18923    5 DERRRAQHNEVERRRRDKINNWIVQLSKIIPDCNTDNSKtgASKGGILSKACDYIRELR----QTNQRMQETYKEAERL 79
bHLHzip_N-Myc_like cd11456
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in N-Myc and similar proteins; N-Myc, ...
 802-881 1.92e-04

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in N-Myc and similar proteins; N-Myc, also termed Class E basic helix-loop-helix protein 37 (bHLHe37), is a bHLHZip proto-oncogene protein that positively regulates the transcription of MYCNOS in neuroblastoma cells. It is also essential during embryonic development. N-Myc has a critical role in regulating the switch between proliferation and differentiation of progenitor cells. It binds DNA as a heterodimer with MAX. The family also includes S-Myc, encoded by rat or mouse intronless myc gene, which has apoptosis-inducing activity.


Pssm-ID: 381462 [Multi-domain]  Cd Length: 87  Bit Score: 41.04  E-value: 1.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25151362  802 ERKRIlHLHAEQNRRSALKDGFDQLMDIIPDLYSGGvKPTNAVVLAKSADHIRRLQAEKWDKTQKIDEAKAKIEKLNQKI 881
Cdd:cd11456    4 ERRRN-HNILERQRRNDLRSSFLTLRDHVPELVKNE-KAAKVVILKKATEYVHSLQAEEQKLLLEKEKLQARQQQLLKKI 81
bHLHzip_Mnt cd11402
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-binding protein Mnt and similar ...
 805-888 2.80e-04

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-binding protein Mnt and similar proteins; Mnt, also termed Class D basic helix-loop-helix protein 3 (bHLHd3), or Myc antagonist MNT, or protein ROX, is a bHLHZip transcriptional repressor that binds DNA as a heterodimer with MAX. It binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'. Mnt has an important role as an antagonist and regulator of Myc activities and it is a potential tumor suppressor. Mnt is ubiquitously expressed. Mnt-deficient mice shown to exhibit early postnatal lethality.


Pssm-ID: 381408 [Multi-domain]  Cd Length: 77  Bit Score: 40.38  E-value: 2.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25151362  805 RILHLHAEQNRRSALKDGFDQLMDIIPDLysGGVKPTNAVVLAKSADHIRRLQaekwdktQKIDEAKAKIEKLNQKITSL 884
Cdd:cd11402    3 REVHNKLEKNRRAHLKECFETLKRQIPNL--DDKKTSNLNILRSALRYIQILK-------RKEKEYEHEMERLAREKIAL 73


                 ....
gi 25151362  885 QSNL 888
Cdd:cd11402   74 QQRL 77
bHLHzip_TFE3 cd18928
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor E3 (TFE3) and ...
 801-881 1.55e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor E3 (TFE3) and similar proteins; TFE3, also termed Class E basic helix-loop-helix protein 33 (bHLHe33), is a bHLHzip transcription factor that is involved in B cell function. It specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Its efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF.


Pssm-ID: 381498 [Multi-domain]  Cd Length: 91  Bit Score: 38.88  E-value: 1.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25151362  801 EERKRILHLHAEQNRRSALKDGFDQLMDIIPDLYSGGVKPTNAVVLAKSADHIRRLQAEKwDKTQKIDEAKAKIEKLNQK 880
Cdd:cd18928    8 ERQKKDNHNLIERRRRFNINDRIKELGTLIPKSTDPEMRWNKGTILKASVDYIRKLQKEQ-QRSKEIEMRQRKLEQANRS 86


                 .
gi 25151362  881 I 881
Cdd:cd18928   87 L 87
bHLHzip_MITF cd18926
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated ...
 798-881 1.76e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins; MITF, also termed Class E basic helix-loop-helix protein 32 (bHLHe32), is a bHLHzip transcription factor that is involved in neural crest melanocytes development as well as the pigmented retinal epithelium. It regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. It binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR).


Pssm-ID: 381496  Cd Length: 104  Bit Score: 38.91  E-value: 1.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25151362  798 LHPEERKRILHLHAEQNRRSALKDGFDQLMDIIPDLYSGGVKPTNAVVLAKSADHIRRLQAEKwDKTQKIDEAKAKIEKL 877
Cdd:cd18926    7 LAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQ-QRAKELENRQKKLEHA 85


                 ....
gi 25151362  878 NQKI 881
Cdd:cd18926   86 NRHL 89
bHLHzip_SREBP_like cd11395
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding ...
 802-859 2.00e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein (SREBP) family and similar proteins; The SREBP family includes SREBP1 and SREBP2, which are bHLHzip transcriptional activator of genes encoding proteins essential for cholesterol biosynthesis/uptake and fatty acid biosynthesis. SREBP1 and SREBP2 are principally found in the liver and in adipocytes and made up of an N-terminal transcription factor portion (composed of an activation domain, a bHLHzip domain, and a nuclear localization signal), a hydrophobic region containing two membrane spanning regions, and a C-terminal regulatory segment. They recognize a symmetric sterol regulatory element (TCACNCCAC) instead of E-box. The family also includes Saccharomyces cerevisiae transcription factor HMS1 (also termed high-copy MEP suppressor protein 1) and serine-rich protein TYE7. HMS1 is a putative bHLHzip transcription factor involved in exit from mitosis and pseudohyphal differentiation. TYE7, also termed basic-helix-loop-helix protein SGC1, is a putative bHLHzip transcription activator required for Ty1-mediated glycolytic gene expression. TYE7 N-terminal is extremely rich in serine residues. It binds DNA on E-box motifs, 5'-CANNTG-3'. TYE7 is not essential for growth.


Pssm-ID: 381401 [Multi-domain]  Cd Length: 87  Bit Score: 38.08  E-value: 2.00e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 25151362  802 ERKRILHLHAEQNRRSALKDGFDQLMDIIPDL----------YSGGV----KPTNAVVLAKSADHIRRLQAE 859
Cdd:cd11395    1 PRKRLPHNAIEKRYRSNLNTKIERLRDAIPSLrspegksddgGLGGLapttKLSKATILTKAIEYIRHLEQE 72
bHLH_AtBIM_like cd11453
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana BES1-interacting Myc-like ...
 805-884 2.70e-03

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana BES1-interacting Myc-like proteins (BIMs) and similar proteins; The family includes Arabidopsis thaliana BIM1 and its homologs (BIM2 and BIM3), which are bHLH transcription factors that interact with BES1 to regulate transcription of Brassinosteroid (BR)-induced gene. BR regulates many growth and developmental processes such as cell elongation, vascular development, senescence stress responses, and photomorphogenesis. BIM1 heterodimerize with BES1 and bind to E-box sequences present in many BR-induced promoters to regulated BR-induced genes.


Pssm-ID: 381459  Cd Length: 77  Bit Score: 37.45  E-value: 2.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25151362  805 RILHLHAEQNRRSALKDGFDQLMDIIPDlysGGVKPTNAVVLAKSADHIRRLQAekwdKTQKIDEakaKIEKLNQKITSL 884
Cdd:cd11453    4 RSKHSATEQRRRSKINERLQALRDLIPH---SDQKRDKASFLLEVIEYIQALQE----KVAKLEE---QVQGWGGEPAKL 73
bHLHzip_scCBP1 cd11398
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Saccharomyces cerevisiae ...
 801-880 3.87e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Saccharomyces cerevisiae centromere-binding protein 1 (CBP-1) and similar proteins; CBP-1, also termed centromere promoter factor 1 (CPF1), or centromere-binding factor 1 (CBF1), is a bHLHzip protein that is required for chromosome stability and methionine prototrophy. It binds as a homodimer to the centromere DNA elements I (CDEI, GTCACATG) region of the centromere that is required for optimal centromere function.


Pssm-ID: 381404 [Multi-domain]  Cd Length: 89  Bit Score: 37.32  E-value: 3.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25151362  801 EERKRILHLHAEQNRRSALKDGFDQLMDIIPdlysGGVKPTN-AVVLAKSADHIRRLQA------EKWdKTQKI--DEAK 871
Cdd:cd11398    4 HRQRRDNHKEVERRRRENINEGINELAALVP----GNAREKNkGAILARAVEYIQELQEteakniEKW-TLEKLltDQAI 78


                 ....*....
gi 25151362  872 AKIEKLNQK 880
Cdd:cd11398   79 AELAALNEK 87
bHLHzip_USF_MITF cd11387
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in USF/MITF family; The USF (upstream ...
 808-859 6.63e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in USF/MITF family; The USF (upstream stimulatory factor)/MITF (microphthalmia-associated transcription factor) family includes two bHLHzip transcription factor subfamilies. USFs are ubiquitously expressed and key regulators of a wide number of gene regulation networks, including the stress and immune responses, cell cycle and proliferation, lipid and glucid metabolism. USFs recruit chromatin remodeling enzymes and interact with co-activators and the members of the transcription pre-initiation complex. USFs interact with high affinity to E-box regulatory elements. The MITF (also known as microphthalmia-TFE, or MiT) subfamily comprises four genes in mammals (MITF, TFE3, TFEB, and TFEC); each gene has different functions. MITF is involved in neural crest melanocytes development as well as the pigmented retinal epithelium. TFEB is required for vascularization of the mouse placenta. TFE3 is involved in B cell function. TFEC regulates gene expression in macrophages. The MITF subfamily proteins can form homodimers or heterodimers with each other but not with other bHLH or bHLHzip proteins.


Pssm-ID: 381393 [Multi-domain]  Cd Length: 58  Bit Score: 36.08  E-value: 6.63e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 25151362  808 HLHAEQNRRSALKDGFDQLMDIIPDLY--SGGVKPTNAVVLAKSADHIRRLQAE 859
Cdd:cd11387    2 HNAVERRRRDNINEKIQELGSLVPPSRleTKDLKPNKGSILSKAVEYIRELQNQ 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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