|
Name |
Accession |
Description |
Interval |
E-value |
| PrsA |
COG0462 |
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ... |
59-372 |
3.54e-167 |
|
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis
Pssm-ID: 440230 [Multi-domain] Cd Length: 311 Bit Score: 469.15 E-value: 3.54e-167
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 59 MPNIKVFSGSSHPDLSTRICERLQLEVSKASLKKFSNKETNVEIGESVRGEDVYIIQSAAGEINDNLMELLIMINACKIA 138
Cdd:COG0462 1 MKDLKIFSGNANPELAEEIAEYLGVPLGKAEVRRFSDGEIYVRIEESVRGRDVFVIQSTSPPVNDNLMELLIMIDALKRA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 139 SSCRVAAVIPAFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAILKYIKES-I 217
Cdd:COG0462 81 SARRITAVIPYYGYARQDRKFRPREPITAKLVADLLEAAGADRVLTVDLHAPQIQGFFDIPVDHLYAAPLLADYIKSKdL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 218 PNWqtsVIVSPDAGGAKRVTSIADRLNVDFALIHKERKRANEVEKMTLVGSVEGKVAILVDDMADTCGTICMAADKLVEA 297
Cdd:COG0462 161 EDL---VVVSPDVGGVKRARAFAKRLGAPLAIIDKRRPGANEVEVMNIIGDVEGKTCIIVDDMIDTGGTLVEAAEALKEA 237
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 453231964 298 GADKVYAFCVHGIFSGPALTRLNASKFEAVVVTNTIPQDENmKKCSKIQCIDISMILAEAIRRTHNGESVSYLFS 372
Cdd:COG0462 238 GAKSVYAAATHGVLSGPAVERLENSPIDELVVTDTIPLPEE-KRCDKIKVLSVAPLLAEAIRRIHEGESVSSLFD 311
|
|
| PRK01259 |
PRK01259 |
ribose-phosphate diphosphokinase; |
62-371 |
5.05e-158 |
|
ribose-phosphate diphosphokinase;
Pssm-ID: 234929 [Multi-domain] Cd Length: 309 Bit Score: 446.10 E-value: 5.05e-158
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 62 IKVFSGSSHPDLSTRICERLQLEVSKASLKKFSNKETNVEIGESVRGEDVYIIQSAAGEINDNLMELLIMINACKIASSC 141
Cdd:PRK01259 1 MKLFAGNANPELAEKIAKYLGIPLGKASVGRFSDGEISVEINENVRGKDVFIIQSTCAPTNDNLMELLIMIDALKRASAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 142 RVAAVIPAFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAILKYIKESipNWQ 221
Cdd:PRK01259 81 RITAVIPYFGYARQDRKARSRVPITAKLVANLLETAGADRVLTMDLHADQIQGFFDIPVDNLYGSPILLEDIKQK--NLE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 222 TSVIVSPDAGGAKRVTSIADRLNVDFALIHKERKRANEVEKMTLVGSVEGKVAILVDDMADTCGTICMAADKLVEAGADK 301
Cdd:PRK01259 159 NLVVVSPDVGGVVRARALAKRLDADLAIIDKRRPRANVSEVMNIIGDVEGRDCILVDDMIDTAGTLCKAAEALKERGAKS 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 302 VYAFCVHGIFSGPALTRLNASKFEAVVVTNTIPQDENMKKCSKIQCIDISMILAEAIRRTHNGESVSYLF 371
Cdd:PRK01259 239 VYAYATHPVLSGGAIERIENSVIDELVVTDSIPLSEEAKKCDKIRVLSVAPLLAEAIRRISNEESVSSLF 308
|
|
| ribP_PPkin |
TIGR01251 |
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ... |
62-372 |
9.29e-142 |
|
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 273523 [Multi-domain] Cd Length: 308 Bit Score: 404.74 E-value: 9.29e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 62 IKVFSGSSHPDLSTRICERLQLEVSKASLKKFSNKETNVEIGESVRGEDVYII-QSAAGEINDNLMELLIMINACKIASS 140
Cdd:TIGR01251 1 MKIFSGSSNQELAQKVAKNLGLPLGDVEVKRFPDGELYVRINESVRGKDVFIIqQSTSAPVNDNLMELLIMIDALKRASA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 141 CRVAAVIPAFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAILKYIKESIPNw 220
Cdd:TIGR01251 81 KSITAVIPYYGYARQDKKFKSREPISAKLVANLLETAGADRVLTVDLHSPQIQGFFDVPVDNLYASPVLAEYLKKKILD- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 221 qTSVIVSPDAGGAKRVTSIADRLNVDFALIHKERK-RANEVEKMTLVGSVEGKVAILVDDMADTCGTICMAADKLVEAGA 299
Cdd:TIGR01251 160 -NPVVVSPDAGGVERAKKVADALGCPLAIIDKRRIsATNEVEVMNLVGDVEGKDVVIVDDIIDTGGTIAKAAEILKSAGA 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 453231964 300 DKVYAFCVHGIFSGPALTRLNASKFEAVVVTNTIPQDenmKKCSKIQCIDISMILAEAIRRTHNGESVSYLFS 372
Cdd:TIGR01251 239 KRVIAAATHGVFSGPAIERIANAGVEEVIVTNTIPHE---KHKPKVSVISVAPLIAEAIRRIHNNESVSSLFD 308
|
|
| Pribosyltran_N |
pfam13793 |
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ... |
62-178 |
8.69e-64 |
|
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.
Pssm-ID: 433483 [Multi-domain] Cd Length: 117 Bit Score: 199.18 E-value: 8.69e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 62 IKVFSGSSHPDLSTRICERLQLEVSKASLKKFSNKETNVEIGESVRGEDVYIIQSAAGEINDNLMELLIMINACKIASSC 141
Cdd:pfam13793 1 LKIFSGNSNPELAEKIAKRLGIPLGKATVSRFSDGEIYVRIEESVRGKDVFIIQSTCPPVNDNLMELLIMIDALKRASAK 80
|
90 100 110
....*....|....*....|....*....|....*..
gi 453231964 142 RVAAVIPAFPYARQDKKDKSRAPISAKLVANMLSVAG 178
Cdd:pfam13793 81 RITAVIPYFGYARQDRKDKPREPITAKLVADLLEAAG 117
|
|
| PRTases_typeI |
cd06223 |
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ... |
205-332 |
9.27e-27 |
|
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.
Pssm-ID: 206754 [Multi-domain] Cd Length: 130 Bit Score: 103.24 E-value: 9.27e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 205 AEPAILKYIKESIpnWQTSVIVSPDAGGAKRVTSIADRLNVDFALIHKERKRANEVEKMT------LVGSVEGKVAILVD 278
Cdd:cd06223 1 AGRLLAEEIREDL--LEPDVVVGILRGGLPLAAALARALGLPLAFIRKERKGPGRTPSEPyglelpLGGDVKGKRVLLVD 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 453231964 279 DMADTCGTICMAADKLVEAGADKVYAFCVHGIFSGPAltRLNASKFEAVVVTNT 332
Cdd:cd06223 79 DVIATGGTLLAAIELLKEAGAKVVGVAVLLDKPEGGA--RELASPGDPVYSLFT 130
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PrsA |
COG0462 |
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ... |
59-372 |
3.54e-167 |
|
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis
Pssm-ID: 440230 [Multi-domain] Cd Length: 311 Bit Score: 469.15 E-value: 3.54e-167
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 59 MPNIKVFSGSSHPDLSTRICERLQLEVSKASLKKFSNKETNVEIGESVRGEDVYIIQSAAGEINDNLMELLIMINACKIA 138
Cdd:COG0462 1 MKDLKIFSGNANPELAEEIAEYLGVPLGKAEVRRFSDGEIYVRIEESVRGRDVFVIQSTSPPVNDNLMELLIMIDALKRA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 139 SSCRVAAVIPAFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAILKYIKES-I 217
Cdd:COG0462 81 SARRITAVIPYYGYARQDRKFRPREPITAKLVADLLEAAGADRVLTVDLHAPQIQGFFDIPVDHLYAAPLLADYIKSKdL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 218 PNWqtsVIVSPDAGGAKRVTSIADRLNVDFALIHKERKRANEVEKMTLVGSVEGKVAILVDDMADTCGTICMAADKLVEA 297
Cdd:COG0462 161 EDL---VVVSPDVGGVKRARAFAKRLGAPLAIIDKRRPGANEVEVMNIIGDVEGKTCIIVDDMIDTGGTLVEAAEALKEA 237
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 453231964 298 GADKVYAFCVHGIFSGPALTRLNASKFEAVVVTNTIPQDENmKKCSKIQCIDISMILAEAIRRTHNGESVSYLFS 372
Cdd:COG0462 238 GAKSVYAAATHGVLSGPAVERLENSPIDELVVTDTIPLPEE-KRCDKIKVLSVAPLLAEAIRRIHEGESVSSLFD 311
|
|
| PRK01259 |
PRK01259 |
ribose-phosphate diphosphokinase; |
62-371 |
5.05e-158 |
|
ribose-phosphate diphosphokinase;
Pssm-ID: 234929 [Multi-domain] Cd Length: 309 Bit Score: 446.10 E-value: 5.05e-158
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 62 IKVFSGSSHPDLSTRICERLQLEVSKASLKKFSNKETNVEIGESVRGEDVYIIQSAAGEINDNLMELLIMINACKIASSC 141
Cdd:PRK01259 1 MKLFAGNANPELAEKIAKYLGIPLGKASVGRFSDGEISVEINENVRGKDVFIIQSTCAPTNDNLMELLIMIDALKRASAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 142 RVAAVIPAFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAILKYIKESipNWQ 221
Cdd:PRK01259 81 RITAVIPYFGYARQDRKARSRVPITAKLVANLLETAGADRVLTMDLHADQIQGFFDIPVDNLYGSPILLEDIKQK--NLE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 222 TSVIVSPDAGGAKRVTSIADRLNVDFALIHKERKRANEVEKMTLVGSVEGKVAILVDDMADTCGTICMAADKLVEAGADK 301
Cdd:PRK01259 159 NLVVVSPDVGGVVRARALAKRLDADLAIIDKRRPRANVSEVMNIIGDVEGRDCILVDDMIDTAGTLCKAAEALKERGAKS 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 302 VYAFCVHGIFSGPALTRLNASKFEAVVVTNTIPQDENMKKCSKIQCIDISMILAEAIRRTHNGESVSYLF 371
Cdd:PRK01259 239 VYAYATHPVLSGGAIERIENSVIDELVVTDSIPLSEEAKKCDKIRVLSVAPLLAEAIRRISNEESVSSLF 308
|
|
| ribP_PPkin |
TIGR01251 |
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ... |
62-372 |
9.29e-142 |
|
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 273523 [Multi-domain] Cd Length: 308 Bit Score: 404.74 E-value: 9.29e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 62 IKVFSGSSHPDLSTRICERLQLEVSKASLKKFSNKETNVEIGESVRGEDVYII-QSAAGEINDNLMELLIMINACKIASS 140
Cdd:TIGR01251 1 MKIFSGSSNQELAQKVAKNLGLPLGDVEVKRFPDGELYVRINESVRGKDVFIIqQSTSAPVNDNLMELLIMIDALKRASA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 141 CRVAAVIPAFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAILKYIKESIPNw 220
Cdd:TIGR01251 81 KSITAVIPYYGYARQDKKFKSREPISAKLVANLLETAGADRVLTVDLHSPQIQGFFDVPVDNLYASPVLAEYLKKKILD- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 221 qTSVIVSPDAGGAKRVTSIADRLNVDFALIHKERK-RANEVEKMTLVGSVEGKVAILVDDMADTCGTICMAADKLVEAGA 299
Cdd:TIGR01251 160 -NPVVVSPDAGGVERAKKVADALGCPLAIIDKRRIsATNEVEVMNLVGDVEGKDVVIVDDIIDTGGTIAKAAEILKSAGA 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 453231964 300 DKVYAFCVHGIFSGPALTRLNASKFEAVVVTNTIPQDenmKKCSKIQCIDISMILAEAIRRTHNGESVSYLFS 372
Cdd:TIGR01251 239 KRVIAAATHGVFSGPAIERIANAGVEEVIVTNTIPHE---KHKPKVSVISVAPLIAEAIRRIHNNESVSSLFD 308
|
|
| PLN02369 |
PLN02369 |
ribose-phosphate pyrophosphokinase |
71-371 |
7.97e-113 |
|
ribose-phosphate pyrophosphokinase
Pssm-ID: 215209 [Multi-domain] Cd Length: 302 Bit Score: 331.27 E-value: 7.97e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 71 PDLSTRICERLQLEVSKASLKKFSNKETNVEIGESVRGEDVYIIQSAAGEINDNLMELLIMINACKIASSCRVAAVIPAF 150
Cdd:PLN02369 1 PALSQEIACYLGLELGKITIKRFADGEIYVQLQESVRGCDVFLVQPTCPPANENLMELLIMIDACRRASAKRITAVIPYF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 151 PYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAILKYIKESIPNWQTSVIVSPDA 230
Cdd:PLN02369 81 GYARADRKTQGRESIAAKLVANLITEAGADRVLACDLHSGQSMGYFDIPVDHVYGQPVILDYLASKTISSPDLVVVSPDV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 231 GGAKRVTSIADRL-NVDFALIHKERKRANEVEKMTLVGSVEGKVAILVDDMADTCGTICMAADKLVEAGADKVYAFCVHG 309
Cdd:PLN02369 161 GGVARARAFAKKLsDAPLAIVDKRRQGHNVAEVMNLIGDVKGKVAIMVDDMIDTAGTITKGAALLHQEGAREVYACATHA 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 453231964 310 IFSGPALTRLNASKFEAVVVTNTIPQDENmKKCSKIQCIDISMILAEAIRRTHNGESVSYLF 371
Cdd:PLN02369 241 VFSPPAIERLSSGLFQEVIVTNTIPVSEK-NYFPQLTVLSVANLLGETIWRVHDDCSVSSIF 301
|
|
| PRK04923 |
PRK04923 |
ribose-phosphate diphosphokinase; |
60-371 |
1.23e-110 |
|
ribose-phosphate diphosphokinase;
Pssm-ID: 179893 [Multi-domain] Cd Length: 319 Bit Score: 326.12 E-value: 1.23e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 60 PNIKVFSGSSHPDLSTRICERLQLEVSKASLKKFSNKETNVEIGESVRGEDVYIIQSAAGEINDNLMELLIMINACKIAS 139
Cdd:PRK04923 5 RNLLVFSGNANKPLAQSICKELGVRMGKALVTRFSDGEVQVEIEESVRRQEVFVIQPTCAPSAENLMELLVLIDALKRAS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 140 SCRVAAVIPAFPYARQDKKDKS-RAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAILKYIkesip 218
Cdd:PRK04923 85 AASVTAVIPYFGYSRQDRRMRSsRVPITAKVAAKMISAMGADRVLTVDLHADQIQGFFDVPVDNVYASPLLLADI----- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 219 nWQTS-----VIVSPDAGGAKRVTSIADRL-NVDFALIHKERKRANEVEKMTLVGSVEGKVAILVDDMADTCGTICMAAD 292
Cdd:PRK04923 160 -WRAYgtdnlIVVSPDVGGVVRARAVAKRLdDADLAIIDKRRPRANVATVMNIIGDVQGKTCVLVDDLVDTAGTLCAAAA 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 453231964 293 KLVEAGADKVYAFCVHGIFSGPALTRLNASKFEAVVVTNTIPQDENMKKCSKIQCIDISMILAEAIRRTHNGESVSYLF 371
Cdd:PRK04923 239 ALKQRGALKVVAYITHPVLSGPAVDNINNSQLDELVVTDTIPLSEAARACAKIRQLSVAELLAETIRRIAFGESVSSLY 317
|
|
| PRK02269 |
PRK02269 |
ribose-phosphate diphosphokinase; |
61-371 |
1.01e-109 |
|
ribose-phosphate diphosphokinase;
Pssm-ID: 167353 [Multi-domain] Cd Length: 320 Bit Score: 324.05 E-value: 1.01e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 61 NIKVFSGSSHPDLSTRICERLQLEVSKASLKKFSNKETNVEIGESVRGEDVYIIQSAAGEINDNLMELLIMINACKIASS 140
Cdd:PRK02269 5 DLKLFALSSNKELAEKVAQEIGIELGKSSVRQFSDGEIQVNIEESIRGHHVFILQSTSSPVNDNLMEILIMVDALKRASA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 141 CRVAAVIPAFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAILKYIKESIPNW 220
Cdd:PRK02269 85 ESINVVMPYYGYARQDRKARSREPITSKLVANMLEVAGVDRLLTVDLHAAQIQGFFDIPVDHLMGAPLIADYFDRRGLVG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 221 QTSVIVSPDAGGAKRVTSIADRLNVDFALIHKERK--RANEVEKMTLVGSVEGKVAILVDDMADTCGTICMAADKLVEAG 298
Cdd:PRK02269 165 DDVVVVSPDHGGVTRARKLAQFLKTPIAIIDKRRSvdKMNTSEVMNIIGNVKGKKCILIDDMIDTAGTICHAADALAEAG 244
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 453231964 299 ADKVYAFCVHGIFSGPALTRLNASKFEAVVVTNTIPQDENmKKCSKIQCIDISMILAEAIRRTHNGESVSYLF 371
Cdd:PRK02269 245 ATEVYASCTHPVLSGPALDNIQKSAIEKLVVLDTIYLPEE-RLIDKIEQISIADLLGEAIIRIHEKRPLSPLF 316
|
|
| PTZ00145 |
PTZ00145 |
phosphoribosylpyrophosphate synthetase; Provisional |
53-371 |
2.65e-108 |
|
phosphoribosylpyrophosphate synthetase; Provisional
Pssm-ID: 240290 [Multi-domain] Cd Length: 439 Bit Score: 324.52 E-value: 2.65e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 53 SEE----DLRMPNIKVFSGSSHPDLSTRICERLQLEVSKASLKKFSNKETNVEIGESVRGEDVYIIQSAAGEINDNLMEL 128
Cdd:PTZ00145 107 SEEkrpfEKKMENAILFSGSSNPLLSKNIADHLGTILGRVHLKRFADGEVSMQFLESIRGKDVYIIQPTCPPVNENLIEL 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 129 LIMINACKIASSCRVAAVIPAFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFD--IPVDNLYAE 206
Cdd:PTZ00145 187 LLMISTCRRASAKKITAVIPYYGYARQDRKLSSRVPISAADVARMIEAMGVDRVVAIDLHSGQIQGFFGprVPVDNLEAQ 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 207 PAILKYIKESipNWQTSVIVSPDAGGAKRVTSIADRLN------VDFALIHKERKRANEVEKMTLVGSVEGKVAILVDDM 280
Cdd:PTZ00145 267 LIGLDYFTKK--DLYKPVIVSPDAGGVYRARKFQDGLNhrgisdCGIAMLIKQRTKPNEIEKMDLVGNVYDSDVIIVDDM 344
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 281 ADTCGTICMAADKLVEAGADKVYAFCVHGIFSGPALTRLNASKFEAVVVTNTIPQDENMKKCSKIQCIDISMILAEAIRR 360
Cdd:PTZ00145 345 IDTSGTLCEAAKQLKKHGARRVFAFATHGLFSGPAIERIEASPLEEVVVTDTVKSNKNIDSCKKITKLSVSVLVADAIRR 424
|
330
....*....|.
gi 453231964 361 THNGESVSYLF 371
Cdd:PTZ00145 425 IHQKESLNDLF 435
|
|
| PRK03092 |
PRK03092 |
ribose-phosphate diphosphokinase; |
73-371 |
1.51e-106 |
|
ribose-phosphate diphosphokinase;
Pssm-ID: 179535 [Multi-domain] Cd Length: 304 Bit Score: 315.35 E-value: 1.51e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 73 LSTRICERLQLEVSKASLKKFSNKETNVEIGESVRGEDVYIIQSAAGEINDNLMELLIMINACKIASSCRVAAVIPAFPY 152
Cdd:PRK03092 1 LAEEVAKELGVEVTPTTAYDFANGEIYVRFEESVRGCDAFVLQSHTAPINKWLMEQLIMIDALKRASAKRITVVLPFYPY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 153 ARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAILKYIKESIPNwQTSVIVSPDAGG 232
Cdd:PRK03092 81 ARQDKKHRGREPISARLVADLFKTAGADRIMTVDLHTAQIQGFFDGPVDHLFAMPLLADYVRDKYDL-DNVTVVSPDAGR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 233 AKRVTSIADRL-NVDFALIHKER--KRANEVEKMTLVGSVEGKVAILVDDMADTCGTICMAADKLVEAGADKVYAFCVHG 309
Cdd:PRK03092 160 VRVAEQWADRLgGAPLAFIHKTRdpTVPNQVVANRVVGDVEGRTCVLVDDMIDTGGTIAGAVRALKEAGAKDVIIAATHG 239
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 453231964 310 IFSGPALTRLNASKFEAVVVTNTIPQDENmKKCSKIQCIDISMILAEAIRRTHNGESVSYLF 371
Cdd:PRK03092 240 VLSGPAAERLKNCGAREVVVTDTLPIPEE-KRFDKLTVLSIAPLLARAIREVFEDGSVTSLF 300
|
|
| PRK02812 |
PRK02812 |
ribose-phosphate pyrophosphokinase; Provisional |
62-371 |
2.38e-103 |
|
ribose-phosphate pyrophosphokinase; Provisional
Pssm-ID: 235072 [Multi-domain] Cd Length: 330 Bit Score: 308.21 E-value: 2.38e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 62 IKVFSGSSHPDLSTRICERLQLEVSKASLKKFSNKETNVEIGESVRGEDVYIIQSAAGEINDNLMELLIMINACKIASSC 141
Cdd:PRK02812 22 LRLFSGSSNPALAQEVARYLGMDLGPMIRKRFADGELYVQIQESIRGCDVYLIQPTCAPVNDHLMELLIMVDACRRASAR 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 142 RVAAVIPAFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAILKYIKESipNWQ 221
Cdd:PRK02812 102 QITAVIPYYGYARADRKTAGRESITAKLVANLITKAGADRVLAMDLHSAQIQGYFDIPCDHVYGSPVLLDYLASK--NLE 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 222 TSVIVSPDAGGAKRVTSIADRLN-VDFALIHKERKRANEVEKMTLVGSVEGKVAILVDDMADTCGTICMAADKLVEAGAD 300
Cdd:PRK02812 180 DIVVVSPDVGGVARARAFAKKLNdAPLAIIDKRRQAHNVAEVLNVIGDVKGKTAILVDDMIDTGGTICEGARLLRKEGAK 259
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 453231964 301 KVYAFCVHGIFSGPALTRLNASKFEAVVVTNTIPQDENmKKCSKIQCIDISMILAEAIRRTHNGESVSYLF 371
Cdd:PRK02812 260 QVYACATHAVFSPPAIERLSSGLFEEVIVTNTIPVPEE-RRFPQLKVLSVANMLGEAIWRIHEESSVSSMF 329
|
|
| PRK02458 |
PRK02458 |
ribose-phosphate pyrophosphokinase; Provisional |
60-375 |
4.50e-91 |
|
ribose-phosphate pyrophosphokinase; Provisional
Pssm-ID: 235039 [Multi-domain] Cd Length: 323 Bit Score: 276.62 E-value: 4.50e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 60 PNIKVFSGSSHPDLSTRICERLQLEVSKASLKKFSNKETNVEIGESVRGEDVYIIQSAAGEINDNLMELLIMINACKIAS 139
Cdd:PRK02458 8 KQIKLFSLNSNLEIAEKIAQAAGVPLGKLSSRQFSDGEIMINIEESVRGDDIYIIQSTSFPVNDHLWELLIMIDACKRAS 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 140 SCRVAAVIPAFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAILKYIKESIPN 219
Cdd:PRK02458 88 ANTVNVVLPYFGYARQDRIAKPREPITAKLVANMLVKAGVDRVLTLDLHAVQVQGFFDIPVDNLFTVPLFAKHYCKKGLS 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 220 WQTSVIVSPDAGGAKRVTSIADRLNVDFALIHKERKRANEvEKMTLVGSVEGKVAILVDDMADTCGTICMAADKLVEAGA 299
Cdd:PRK02458 168 GSDVVVVSPKNSGIKRARSLAEYLDAPIAIIDYAQDDSER-EEGYIIGDVAGKKAILIDDILNTGKTFAEAAKIVEREGA 246
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 453231964 300 DKVYAFCVHGIFSGPALTRLNASKFEAVVVTNTIPQDEnmKKCSKIQCIDISMILAEAIRRTHNGESVSYLFSHVP 375
Cdd:PRK02458 247 TEIYAVASHGLFAGGAAEVLENAPIKEILVTDSVATKE--RVPKNVTYLSASELIADAIIRIHERKPLSPLFAYNK 320
|
|
| PRK00553 |
PRK00553 |
ribose-phosphate pyrophosphokinase; Provisional |
64-372 |
5.04e-79 |
|
ribose-phosphate pyrophosphokinase; Provisional
Pssm-ID: 179062 [Multi-domain] Cd Length: 332 Bit Score: 245.98 E-value: 5.04e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 64 VFSGSSHPDLSTRICERLQLEVSKASLKKFSNKETNVEIGESVRGEDVYIIQSAAGEINDNLMELLIMINACKIASSCRV 143
Cdd:PRK00553 12 IFSLSKAKKLVDSICRKLSMKPGEIVIQKFADGETYIRFDESVRNKDVVIFQSTCSPVNDSLMELLIAIDALKRGSAKSI 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 144 AAVIPAFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAILKYIKESIPNwQTS 223
Cdd:PRK00553 92 TAILPYYGYARQDRKTAGREPITSKLVADLLTKAGVTRVTLTDIHSDQTQGFFDIPVDILRTYHVFLSRVLELLGK-KDL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 224 VIVSPDAGGAKRVTSIADRLNVDFALIHKERKRANEVEKMTLVGSVEGKVAILVDDMADTCGTICMAADKLVEAGADKVY 303
Cdd:PRK00553 171 VVVSPDYGGVKRARLIAESLELPLAIIDKRRPKHNVAESINVLGEVKNKNCLIVDDMIDTGGTVIAAAKLLKKQKAKKVC 250
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 453231964 304 AFCVHGIFSGPALTRL----NASKFEAVVVTNTIPQDEnMKKCSKIQCIDISMILAEAIRRTHNGESVSYLFS 372
Cdd:PRK00553 251 VMATHGLFNKNAIQLFdeafKKKLIDKLFVSNSIPQTK-FEKKPQFKVVDLAHLYEEVLLCYANGGSISAIYT 322
|
|
| PRK00934 |
PRK00934 |
ribose-phosphate pyrophosphokinase; Provisional |
63-360 |
5.13e-64 |
|
ribose-phosphate pyrophosphokinase; Provisional
Pssm-ID: 234868 [Multi-domain] Cd Length: 285 Bit Score: 205.53 E-value: 5.13e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 63 KVFSGSSHPDLSTRICERLQLEVSKASLKKFSNKETNVEIGESVRGEDVYIIQSAAGEiNDNLMELLIMINACKIASSCR 142
Cdd:PRK00934 1 MIIGGSASQLLASEVARLLNTELALVETKRFPDGELYVRILGEIDGEDVVIISTTYPQ-DENLVELLLLIDALRDEGAKS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 143 VAAVIPAFPYARQDKKDKSRAPISAKLVANMLSVAGaDHIITMDLHASQIQGFFDIPVDNLYAEPAILKYIKESIPNwqt 222
Cdd:PRK00934 80 ITLVIPYLGYARQDKRFKPGEPISARAIAKIISAYY-DRIITINIHEPSILEFFPIPFINLDAAPLIAEYIGDKLDD--- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 223 SVIVSPDAGGAKRVTSIADRLNVDFALIHKERKRANEVEKMTLVGSVEGKVAILVDDMADTCGTICMAADKLVEAGADKV 302
Cdd:PRK00934 156 PLVLAPDKGALELAKEAAEILGCEYDYLEKTRISPTEVEIAPKNLDVKGKDVLIVDDIISTGGTMATAIKILKEQGAKKV 235
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 453231964 303 YAFCVHGIFSGPALTRLNASKFEAVVVTNTIPqdenmKKCSKiqcIDISMILAEAIRR 360
Cdd:PRK00934 236 YVACVHPVLVGDAILKLYNAGVDEIIVTDTLE-----SEVSK---ISVAPLIADLLKK 285
|
|
| Pribosyltran_N |
pfam13793 |
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ... |
62-178 |
8.69e-64 |
|
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.
Pssm-ID: 433483 [Multi-domain] Cd Length: 117 Bit Score: 199.18 E-value: 8.69e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 62 IKVFSGSSHPDLSTRICERLQLEVSKASLKKFSNKETNVEIGESVRGEDVYIIQSAAGEINDNLMELLIMINACKIASSC 141
Cdd:pfam13793 1 LKIFSGNSNPELAEKIAKRLGIPLGKATVSRFSDGEIYVRIEESVRGKDVFIIQSTCPPVNDNLMELLIMIDALKRASAK 80
|
90 100 110
....*....|....*....|....*....|....*..
gi 453231964 142 RVAAVIPAFPYARQDKKDKSRAPISAKLVANMLSVAG 178
Cdd:pfam13793 81 RITAVIPYFGYARQDRKDKPREPITAKLVADLLEAAG 117
|
|
| Pribosyl_synth |
pfam14572 |
Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes ... |
219-371 |
1.48e-44 |
|
Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes from class EC:2.7.6.1, phosphoribosyl-pyrophosphate transferase.
Pssm-ID: 434046 Cd Length: 184 Bit Score: 151.89 E-value: 1.48e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 219 NWQTSVIVSPDAGGAKRVTSIADRLNVDFALIHKERKRANEVE------------------------------KMTLVGS 268
Cdd:pfam14572 1 DYRNAVIVARSPGSAKRATSFAERLRLGIAVIHGEQKEAESDEvdgrqspppyrsrtvsrslglpeiipkekpPMTVVGD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 269 VEGKVAILVDDMADTCGTICMAADKLVEAGADKVYAFCVHGIFSGPALTRLNASKFEAVVVTNTIPQDENMKKCSKIQCI 348
Cdd:pfam14572 81 VGGRIAIIVDDMIDDVDSFVAAAELLKERGAYKIYVMATHGLLSSDAPRLLEASPIDEVVVTNTIPHEIQKMQCHKIKTI 160
|
170 180
....*....|....*....|...
gi 453231964 349 DISMILAEAIRRTHNGESVSYLF 371
Cdd:pfam14572 161 DISQLIAEAIRRIHNGESMSYLF 183
|
|
| PRK07199 |
PRK07199 |
ribose-phosphate diphosphokinase; |
72-360 |
4.02e-40 |
|
ribose-phosphate diphosphokinase;
Pssm-ID: 235960 [Multi-domain] Cd Length: 301 Bit Score: 143.93 E-value: 4.02e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 72 DLSTRICERLQLEVSKASLKKFSNKETNVEIGESVRGEDVYIIQSAAgEINDNLMELLIMINACKIASSCRVAAVIPAFP 151
Cdd:PRK07199 13 AAAGRLAAALGVEVGRIELHRFPDGESYVRLDSPVAGRTVVLVCSLD-RPDEKLLPLLFAAEAARELGARRVGLVAPYLA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 152 YARQDKKDKSRAPISAKLVANMLSvAGADHIITMD--LH-ASQIQGFFDIPVDNLYAEPAILKYIKESIPNWqtsVIVSP 228
Cdd:PRK07199 92 YMRQDIAFHPGEAISQRHFARLLS-GSFDRLVTVDphLHrYPSLSEVYPIPAVVLSAAPAIAAWIRAHVPRP---LLIGP 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 229 DAGGAKRVTSIADRLNVDFALIHKERKRANEVEkMTL--VGSVEGKVAILVDDMADTCGTICMAADKLVEAGADKVYAFC 306
Cdd:PRK07199 168 DEESEQWVAAVAERAGAPHAVLRKTRHGDRDVE-ISLpdAAPWAGRTPVLVDDIVSTGRTLIEAARQLRAAGAASPDCVV 246
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 453231964 307 VHGIFSGPALTRLNASKFEAVVVTNTIPQDENMkkcskiqcIDISMILAEAIRR 360
Cdd:PRK07199 247 VHALFAGDAYSALAAAGIARVVSTDTVPHPSNA--------ISLAPLLAEALRR 292
|
|
| PRK06827 |
PRK06827 |
phosphoribosylpyrophosphate synthetase; Provisional |
87-370 |
4.06e-40 |
|
phosphoribosylpyrophosphate synthetase; Provisional
Pssm-ID: 180714 [Multi-domain] Cd Length: 382 Bit Score: 145.87 E-value: 4.06e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 87 KASLKKFSNKETNVEIGESVRGEDVYIIQ---------SAAGE-----INDNLMELLIMINACKiASSCRVAAVIPAFPY 152
Cdd:PRK06827 56 PAKFIRFSNGEAKGEILESVRGKDIYILQdvgnysvtyNMFGEknhmsPDDHFQDLKRTIDAIR-GKARRITVIMPFLYE 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 153 ARQDKKdKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIP-VDNLYAEPAILKYIKESIPNWQTS----VIVS 227
Cdd:PRK06827 135 SRQHKR-KGRESLDCALALQELEELGVDNIITFDAHDPRIENAIPLMgFENLYPSYQIIKALLKNEKDLEIDkdhlMVIS 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 228 PDAGGAKRVTSIADRLNVDFALIHKERK-------RANEVEKMTLVGSVEGKVAILVDDMADTCGTICMAADKLVEAGAD 300
Cdd:PRK06827 214 PDTGAMDRAKYYASVLGVDLGLFYKRRDysrvvngRNPIVAHEFLGRDVEGKDVLIVDDMIASGGSMIDAAKELKSRGAK 293
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 453231964 301 KVYAFCVHGIFSGpALTRL----NASKFEAVVVTNTIPQDENMKKCSKIQCIDISMILAEAIRRTHNGESVSYL 370
Cdd:PRK06827 294 KIIVAATFGFFTN-GLEKFdkayEEGYFDRIIGTNLVYHPEELLSKPWYIEVDMSKLIARIIDALNHDVSLSKL 366
|
|
| PRTases_typeI |
cd06223 |
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ... |
205-332 |
9.27e-27 |
|
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.
Pssm-ID: 206754 [Multi-domain] Cd Length: 130 Bit Score: 103.24 E-value: 9.27e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 205 AEPAILKYIKESIpnWQTSVIVSPDAGGAKRVTSIADRLNVDFALIHKERKRANEVEKMT------LVGSVEGKVAILVD 278
Cdd:cd06223 1 AGRLLAEEIREDL--LEPDVVVGILRGGLPLAAALARALGLPLAFIRKERKGPGRTPSEPyglelpLGGDVKGKRVLLVD 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 453231964 279 DMADTCGTICMAADKLVEAGADKVYAFCVHGIFSGPAltRLNASKFEAVVVTNT 332
Cdd:cd06223 79 DVIATGGTLLAAIELLKEAGAKVVGVAVLLDKPEGGA--RELASPGDPVYSLFT 130
|
|
| PLN02297 |
PLN02297 |
ribose-phosphate pyrophosphokinase |
91-335 |
1.68e-10 |
|
ribose-phosphate pyrophosphokinase
Pssm-ID: 177934 [Multi-domain] Cd Length: 326 Bit Score: 61.63 E-value: 1.68e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 91 KKFSNKETNVEIG--ESVRGEDVYIIqsAAGEINDNLMELLIMINACK---IASscrVAAVIPAFP---YAR-QDKKDKS 161
Cdd:PLN02297 47 RKFPDGFPNLFINnaHGIRGQHVAFL--ASFSSPAVIFEQLSVIYALPklfVAS---FTLVLPFFPtgtSERvEREGDVA 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 162 RAPISAKLVANM-LSVAGADHIITMDLHASQIQGFFDipvDNLYA--EPAI--LKYIKESIPNWQTSVIVSPDAGGAKRV 236
Cdd:PLN02297 122 TAFTLARILSNIpISRGGPTSLVIFDIHALQERFYFG---DNVLPcfESGIplLKKRLQQLPDSDNIVIAFPDDGAWKRF 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 237 TSIADrlnvDFALIHKERKRANEVEKMTLV-GSVEGKVAILVDDMADTCGTICMAADKLVEAGADKVYAFCVHGIFSGPA 315
Cdd:PLN02297 199 HKQFE----HFPMVVCTKVREGDKRIVRIKeGNPAGRHVVIVDDLVQSGGTLIECQKVLAAHGAAKVSAYVTHGVFPNES 274
|
250 260
....*....|....*....|....*.
gi 453231964 316 LTRLNASK------FEAVVVTNTIPQ 335
Cdd:PLN02297 275 WERFTHDNggpeagFAYFWITDSCPQ 300
|
|
| Pribosyltran |
pfam00156 |
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl ... |
199-302 |
3.46e-10 |
|
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1. Amidophosphoribosyltransferase EC:2.4.2.14. Orotate phosphoribosyl-transferase EC:2.4.2.10. Uracil phosphoribosyl-transferase EC:2.4.2.9. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain.
Pssm-ID: 425489 [Multi-domain] Cd Length: 150 Bit Score: 57.76 E-value: 3.46e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 199 PVDNLYAEPAILKYIKESI------PNWQTSVIVSPDAGGAKRVTSIADRLNVDFALIHKERKRANEVEKMTLV---GSV 269
Cdd:pfam00156 1 SVDEILDNPAILKAVARLAaqinedYGGKPDVVVGILRGGLPFAGILARRLDVPLAFVRKVSYNPDTSEVMKTSsalPDL 80
|
90 100 110
....*....|....*....|....*....|...
gi 453231964 270 EGKVAILVDDMADTCGTICMAADKLVEAGADKV 302
Cdd:pfam00156 81 KGKTVLIVDDILDTGGTLLKVLELLKNVGPKEV 113
|
|
| PLN02293 |
PLN02293 |
adenine phosphoribosyltransferase |
223-307 |
1.08e-04 |
|
adenine phosphoribosyltransferase
Pssm-ID: 177930 Cd Length: 187 Bit Score: 42.74 E-value: 1.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 223 SVIVSPDAGGAKRVTSIADRLNVDFALIHKERKRANEV--EKMTL----------VGSVE-GKVAILVDDMADTCGTICm 289
Cdd:PLN02293 64 SVVAGIEARGFIFGPPIALAIGAKFVPLRKPGKLPGEVisEEYVLeygtdclemhVGAVEpGERALVIDDLIATGGTLC- 142
|
90
....*....|....*....
gi 453231964 290 AADKLVE-AGADKVYAFCV 307
Cdd:PLN02293 143 AAINLLErAGAEVVECACV 161
|
|
| PyrE |
COG0461 |
Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate ... |
208-307 |
5.39e-04 |
|
Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate phosphoribosyltransferase is part of the Pathway/BioSystem: Pyrimidine biosynthesis
Pssm-ID: 440229 Cd Length: 201 Bit Score: 40.91 E-value: 5.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 208 AILKYIKESIPNwqTSVIVSPDAGGAKRVTSIADRLNVDFALIHKERKraNEVEKMTLVGSV-EGKVAILVDDMADTCGT 286
Cdd:COG0461 52 ALAELIKELGPE--FDAVAGPATGGIPLAAAVARALGLPAIFVRKEAK--DHGTGGQIEGGLlPGERVLVVEDVITTGGS 127
|
90 100
....*....|....*....|.
gi 453231964 287 ICMAADKLVEAGADKVYAFCV 307
Cdd:COG0461 128 VLEAVEALREAGAEVVGVAVI 148
|
|
| pyrE |
PRK00455 |
orotate phosphoribosyltransferase; Validated |
208-323 |
2.51e-03 |
|
orotate phosphoribosyltransferase; Validated
Pssm-ID: 234771 Cd Length: 202 Bit Score: 38.60 E-value: 2.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 208 AILKYIKESIPNWQtsVIVSPDAGGAKRVTSIADRLNVDFALIHKERKraNEVEKMTLVGS-VEGKVAILVDDMADTCGT 286
Cdd:PRK00455 53 FLAEAIKDSGIEFD--VVAGPATGGIPLAAAVARALDLPAIFVRKEAK--DHGEGGQIEGRrLFGKRVLVVEDVITTGGS 128
|
90 100 110
....*....|....*....|....*....|....*..
gi 453231964 287 ICMAADKLVEAGADkvyafcVHGIFSgpALTRLNASK 323
Cdd:PRK00455 129 VLEAVEAIRAAGAE------VVGVAV--IVDRQSAAQ 157
|
|
| PRK02304 |
PRK02304 |
adenine phosphoribosyltransferase; Provisional |
203-307 |
7.75e-03 |
|
adenine phosphoribosyltransferase; Provisional
Pssm-ID: 235028 Cd Length: 175 Bit Score: 36.98 E-value: 7.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453231964 203 LYAEPAILKY----IKESIPNWQTSVIVSPDA-----GGAkrvtsIADRLNVDFALIhkeRKR----------------- 256
Cdd:PRK02304 29 LLADPEAFREvidaLVERYKDADIDKIVGIEArgfifGAA-----LAYKLGIGFVPV---RKPgklpretisesyeleyg 100
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 453231964 257 ANEVEkMTLVGSVEGKVAILVDDMADTCGTIcMAADKLVE-AGADKVYAFCV 307
Cdd:PRK02304 101 TDTLE-IHKDAIKPGDRVLIVDDLLATGGTL-EAAIKLLErLGAEVVGAAFV 150
|
|
| |
