|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
19-391 |
4.77e-145 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 417.31 E-value: 4.77e-145
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 19 EGNYDEVVESFDDMELKEELLRGIYGFGFEKPSAIQKSAVAPCTTGKDVTIQSQAGSGKTVISLIDILQGIDCEDAHLQV 98
Cdd:PTZ00424 20 ESNYDEIVDSFDALKLNEDLLRGIYSYGFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATFVIAALQLIDYDLNACQA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 99 ILLAPQRGMAQRAHEQLKSLGRNLNVNA-TCLGfdTTAENDKIS------HVLMGTPK---DFLSNIPSDTSRIKMFVLD 168
Cdd:PTZ00424 100 LILAPTRELAQQIQKVVLALGDYLKVRChACVG--GTVVRDDINklkagvHMVVGTPGrvyDMIDKRHLRVDDLKLFILD 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 169 EADEMLSKGFKDQIYEVFRSMPQDVQVVLLSATMPSEVLDVTNRFMRDPIRILVKKDELTLEGIRQFYINVQKDEWKFNC 248
Cdd:PTZ00424 178 EADEMLSRGFKGQIYDVFKKLPPDVQVALFSATMPNEILELTTKFMRDPKRILVKKDELTLEGIRQFYVAVEKEEWKFDT 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 249 LCDLLKTSRETQALIFCNTRRRVTQLTEQLMSIPIKVSCFHGNMEHNEREDMVKDFNSRNTRVLVTTDLMARGMNIRK-S 327
Cdd:PTZ00424 258 LCDLYETLTITQAIIYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTRVLITTDLLARGIDVQQvS 337
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 922580233 328 LIINYDVSGNMENYMLRNGRQGNFGSKGLPISFFTENDISDLKKIENHYSTRIEEMPESFLEYL 391
Cdd:PTZ00424 338 LVINYDLPASPENYIHRIGRSGRFGRKGVAINFVTPDDIEQLKEIERHYNTQIEEMPMEVADYL 401
|
|
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
28-393 |
1.91e-97 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 296.67 E-value: 1.91e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 28 SFDDMELKEELLRGIYGFGFEKPSAIQKSAVAPCTTGKDVTIQSQAGSGKTVISLIDILQGIDCEDA-HLQVILLAPQRG 106
Cdd:COG0513 3 SFADLGLSPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRLDPSRPrAPQALILAPTRE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 107 MAQRAHEQLKSLGRNLNVNATCL--GFDTTAENDKIS---HVLMGTP---KDFLS--NIpsDTSRIKMFVLDEADEMLSK 176
Cdd:COG0513 83 LALQVAEELRKLAKYLGLRVATVygGVSIGRQIRALKrgvDIVVATPgrlLDLIErgAL--DLSGVETLVLDEADRMLDM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 177 GFKDQIYEVFRSMPQDVQVVLLSATMPSEVLDVTNRFMRDPIRILVKKDELTLEGIRQFYINVQKDEwKFNCLCDLLKTS 256
Cdd:COG0513 161 GFIEDIERILKLLPKERQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPENATAETIEQRYYLVDKRD-KLELLRRLLRDE 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 257 RETQALIFCNTRRRVTQLTEQLMSIPIKVSCFHGNMEHNEREDMVKDFNSRNTRVLVTTDLMARGMNI-RKSLIINYDVS 335
Cdd:COG0513 240 DPERAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVATDVAARGIDIdDVSHVINYDLP 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 922580233 336 GNMENYMLRNGRQGNFGSKGLPISFFTENDISDLKKIENHYSTRIEEMPESFLEYLDE 393
Cdd:COG0513 320 EDPEDYVHRIGRTGRAGAEGTAISLVTPDERRLLRAIEKLIGQKIEEEELPGFEPVEE 377
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
29-221 |
4.71e-84 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 254.68 E-value: 4.71e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 29 FDDMELKEELLRGIYGFGFEKPSAIQKSAVAPCTTGKDVTIQSQAGSGKTVISLIDILQGIDCEDAHLQVILLAPQRGMA 108
Cdd:cd18046 1 FDDMNLKESLLRGIYAYGFEKPSAIQQRAIMPCIKGYDVIAQAQSGTGKTATFSISILQQIDTSLKATQALVLAPTRELA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 109 QRAHEQLKSLGRNLNVNA-TCLGfDTTAEND-----KISHVLMGTPK---DFLSNIPSDTSRIKMFVLDEADEMLSKGFK 179
Cdd:cd18046 81 QQIQKVVMALGDYMGIKChACIG-GTSVRDDaqklqAGPHIVVGTPGrvfDMINRRYLRTDYIKMFVLDEADEMLSRGFK 159
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 922580233 180 DQIYEVFRSMPQDVQVVLLSATMPSEVLDVTNRFMRDPIRIL 221
Cdd:cd18046 160 DQIYDIFQKLPPDTQVVLLSATMPNDVLEVTTKFMRDPIRIL 201
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
31-221 |
2.77e-72 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 224.51 E-value: 2.77e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 31 DMELKEELLRGIYGFGFEKPSAIQKSAVAPCTTGKDVTIQSQAGSGKTVISLIDILQGIDCEDAHLQVILLAPQRGMAQR 110
Cdd:cd17939 1 DMGLSEDLLRGIYAYGFEKPSAIQQRAIVPIIKGRDVIAQAQSGTGKTATFSIGALQRIDTTVRETQALVLAPTRELAQQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 111 AHEQLKSLGRNLNVNA-TCLGFDTTAENDKI----SHVLMGTP---KDFLSNIPSDTSRIKMFVLDEADEMLSKGFKDQI 182
Cdd:cd17939 81 IQKVVKALGDYMGVKVhACIGGTSVREDRRKlqygPHIVVGTPgrvFDMLQRRSLRTDKIKMFVLDEADEMLSRGFKDQI 160
|
170 180 190
....*....|....*....|....*....|....*....
gi 922580233 183 YEVFRSMPQDVQVVLLSATMPSEVLDVTNRFMRDPIRIL 221
Cdd:cd17939 161 YDIFQFLPPETQVVLFSATMPHEVLEVTKKFMRDPVRIL 199
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
29-221 |
5.53e-61 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 195.76 E-value: 5.53e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 29 FDDMELKEELLRGIYGFGFEKPSAIQKSAVAPCTTGKDVTIQSQAGSGKTVISLIDILQGIDCEDAHLQVILLAPQRGMA 108
Cdd:cd18045 1 FETMGLREDLLRGIYAYGFEKPSAIQQRAIKPIIKGRDVIAQSQSGTGKTATFSISVLQCLDIQVRETQALILSPTRELA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 109 QRAHEQLKSLGRNLNVNA-TCLGFDTTAEN----DKISHVLMGTPK---DFLSNIPSDTSRIKMFVLDEADEMLSKGFKD 180
Cdd:cd18045 81 VQIQKVLLALGDYMNVQChACIGGTSVGDDirklDYGQHIVSGTPGrvfDMIRRRSLRTRHIKMLVLDEADEMLNKGFKE 160
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 922580233 181 QIYEVFRSMPQDVQVVLLSATMPSEVLDVTNRFMRDPIRIL 221
Cdd:cd18045 161 QIYDVYRYLPPATQVVLVSATLPQDILEMTNKFMTDPIRIL 201
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
28-381 |
3.21e-57 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 193.86 E-value: 3.21e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 28 SFDDMELKEELLRGIYGFGFEKPSAIQKSAVAPCTTGKDVTIQSQAGSGKTVISLIDILQGIDCEDAHLQVILLAPQRGM 107
Cdd:PRK11776 5 AFSTLPLPPALLANLNELGYTEMTPIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLGLLQKLDVKRFRVQALVLCPTREL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 108 A-QRAHEqLKSLGR---NLNVNATCLGFDTTAENDKI---SHVLMGTP---KDFLSNIPSDTSRIKMFVLDEADEMLSKG 177
Cdd:PRK11776 85 AdQVAKE-IRRLARfipNIKVLTLCGGVPMGPQIDSLehgAHIIVGTPgriLDHLRKGTLDLDALNTLVLDEADRMLDMG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 178 FKDQIYEVFRSMPQDVQVVLLSATMPSEVLDVTNRFMRDPIRILV--KKDELTlegIRQFYINVQKDEwKFNCLCDLLKT 255
Cdd:PRK11776 164 FQDAIDAIIRQAPARRQTLLFSATYPEGIAAISQRFQRDPVEVKVesTHDLPA---IEQRFYEVSPDE-RLPALQRLLLH 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 256 SRETQALIFCNTRRRVTQLTEQLMSIPIKVSCFHGNMEHNEREDMVKDFNSRNTRVLVTTDLMARGMNIrKSL--IINYD 333
Cdd:PRK11776 240 HQPESCVVFCNTKKECQEVADALNAQGFSALALHGDLEQRDRDQVLVRFANRSCSVLVATDVAARGLDI-KALeaVINYE 318
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 922580233 334 VSGNMENYMLRNGRQGNFGSKGLPISFFTENDISDLKKIENHYSTRIE 381
Cdd:PRK11776 319 LARDPEVHVHRIGRTGRAGSKGLALSLVAPEEMQRANAIEDYLGRKLN 366
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
38-220 |
3.53e-46 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 156.83 E-value: 3.53e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 38 LLRGIYGFGFEKPSAIQKSAVAPCTTGKDVTIQSQAGSGKTVISLIDILQGIDCEDA----HLQVILLAPQRGMAQRAHE 113
Cdd:cd00268 1 LLKALKKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKLLPEPKkkgrGPQALVLAPTRELAMQIAE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 114 QLKSLGRNLNVNATCL--GFDTTAENDKIS---HVLMGTP---KDFLSNIPSDTSRIKMFVLDEADEMLSKGFKDQIYEV 185
Cdd:cd00268 81 VARKLGKGTGLKVAAIygGAPIKKQIEALKkgpDIVVGTPgrlLDLIERGKLDLSNVKYLVLDEADRMLDMGFEEDVEKI 160
|
170 180 190
....*....|....*....|....*....|....*
gi 922580233 186 FRSMPQDVQVVLLSATMPSEVLDVTNRFMRDPIRI 220
Cdd:cd00268 161 LSALPKDRQTLLFSATLPEEVKELAKKFLKNPVRI 195
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
29-373 |
7.76e-46 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 162.80 E-value: 7.76e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 29 FDDMELKEELLRGIYGFGFEKPSAIQKSAVAPCTTGKDVTIQSQAGSGKTVISLIDILQgidcedaHL-----------Q 97
Cdd:PRK11192 3 FSELELDESLLEALQDKGYTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPALQ-------HLldfprrksgppR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 98 VILLAPQRGMAQRAHEQLKSLGRNLNVN-ATCLG-------FDTTAENDKIshvLMGTPKDFLSNIPS---DTSRIKMFV 166
Cdd:PRK11192 76 ILILTPTRELAMQVADQARELAKHTHLDiATITGgvaymnhAEVFSENQDI---VVATPGRLLQYIKEenfDCRAVETLI 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 167 LDEADEMLSKGFKdqiyevfrsmpQDV-----------QVVLLSATMPSE-VLDVTNRFMRDPIRILVKKDELTLEGIRQ 234
Cdd:PRK11192 153 LDEADRMLDMGFA-----------QDIetiaaetrwrkQTLLFSATLEGDaVQDFAERLLNDPVEVEAEPSRRERKKIHQ 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 235 FYINVQKDEWKFNCLCDLLKTSRETQALIFCNTRRRVTQLTEQLMSIPIKVSCFHGNMEHNEREDMVKDFNSRNTRVLVT 314
Cdd:PRK11192 222 WYYRADDLEHKTALLCHLLKQPEVTRSIVFVRTRERVHELAGWLRKAGINCCYLEGEMVQAKRNEAIKRLTDGRVNVLVA 301
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 315 TDLMARGMNIRK-SLIINYDVSGNMENYMLRNGRQGNFGSKGLPISFFTENDISDLKKIE 373
Cdd:PRK11192 302 TDVAARGIDIDDvSHVINFDMPRSADTYLHRIGRTGRAGRKGTAISLVEAHDHLLLGKIE 361
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
24-383 |
1.39e-45 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 165.79 E-value: 1.39e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 24 EVVESFDDMELKEELLRGIYGFGFEKPSAIQKSAVAPCTTGKDVTIQSQAGSGKTVISLIDILQGIDCEDAHLQVILLAP 103
Cdd:PRK11634 3 EFETTFADLGLKAPILEALNDLGYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLLHNLDPELKAPQILVLAP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 104 QRGMAQRAHEQLKSLG---RNLNVNATCLG--FDTTAENDKIS-HVLMGTPKDFLSNIPS---DTSRIKMFVLDEADEML 174
Cdd:PRK11634 83 TRELAVQVAEAMTDFSkhmRGVNVVALYGGqrYDVQLRALRQGpQIVVGTPGRLLDHLKRgtlDLSKLSGLVLDEADEML 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 175 SKGFKDQIYEVFRSMPQDVQVVLLSATMPSEVLDVTNRFMRDPIRILVKKDELTLEGIRQFYINVQKDEwKFNCLCDLLK 254
Cdd:PRK11634 163 RMGFIEDVETIMAQIPEGHQTALFSATMPEAIRRITRRFMKEPQEVRIQSSVTTRPDISQSYWTVWGMR-KNEALVRFLE 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 255 TSRETQALIFCNTRRRVTQLTEQLMSIPIKVSCFHGNMEHNEREDMVKDFNSRNTRVLVTTDLMARGMNI-RKSLIINYD 333
Cdd:PRK11634 242 AEDFDAAIIFVRTKNATLEVAEALERNGYNSAALNGDMNQALREQTLERLKDGRLDILIATDVAARGLDVeRISLVVNYD 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 922580233 334 VSGNMENYMLRNGRQGNFGSKGLPISFFTENDISDLKKIENHYSTRIEEM 383
Cdd:PRK11634 322 IPMDSESYVHRIGRTGRAGRAGRALLFVENRERRLLRNIERTMKLTIPEV 371
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
51-209 |
1.38e-42 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 146.62 E-value: 1.38e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 51 SAIQKSAVAPCTTGKDVTIQSQAGSGKTVISLIDILQGIDCEDAHLQVILLAPQRGMAQRAHEQLKSLGRNLNVNATCL- 129
Cdd:pfam00270 1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDNGPQALVLAPTRELAEQIYEELKKLGKGLGLKVASLl 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 130 -GFDTTAENDKI--SHVLMGTPKDFLSNIP--SDTSRIKMFVLDEADEMLSKGFKDQIYEVFRSMPQDVQVVLLSATMPS 204
Cdd:pfam00270 81 gGDSRKEQLEKLkgPDILVGTPGRLLDLLQerKLLKNLKLLVLDEAHRLLDMGFGPDLEEILRRLPKKRQILLLSATLPR 160
|
....*
gi 922580233 205 EVLDV 209
Cdd:pfam00270 161 NLEDL 165
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
29-220 |
4.89e-42 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 146.29 E-value: 4.89e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 29 FDDMELKEELLRGIYGFGFEKPSAIQKSAVAPCTTGKDVTIQSQAGSGKTVISLIDILQGIDCEDAHLQVILLAPQRGMA 108
Cdd:cd17940 1 FEDYGLKRELLMGIFEKGFEKPSPIQEESIPIALSGRDILARAKNGTGKTGAYLIPILEKIDPKKDVIQALILVPTRELA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 109 QRAHEQLKSLGRNLNVNATCLGFDTTAENDKIS-----HVLMGTPK---DFLSNIPSDTSRIKMFVLDEADEMLSKGFKD 180
Cdd:cd17940 81 LQTSQVCKELGKHMGVKVMVTTGGTSLRDDIMRlyqtvHVLVGTPGrilDLAKKGVADLSHCKTLVLDEADKLLSQDFQP 160
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 922580233 181 QIYEVFRSMPQDVQVVLLSATMPSEVLDVTNRFMRDPIRI 220
Cdd:cd17940 161 IIEKILNFLPKERQILLFSATFPLTVKNFMDRHMHNPYEI 200
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
232-361 |
2.68e-40 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 139.56 E-value: 2.68e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 232 IRQFYINVQKDEWKFNCLCDLLKTSRETQALIFCNTRRRVTQLTEQLMSIPIKVSCFHGNMEHNEREDMVKDFNSRNTRV 311
Cdd:cd18787 1 IKQLYVVVEEEEKKLLLLLLLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVRV 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 922580233 312 LVTTDLMARGMNIRK-SLIINYDVSGNMENYMLRNGRQGNFGSKGLPISFF 361
Cdd:cd18787 81 LVATDVAARGLDIPGvDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
26-362 |
7.92e-40 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 148.77 E-value: 7.92e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 26 VESFDDMELKEELLRGIYGFGFEKPSAIQKSAVAPCTTGKDVTIQSQAGSGKTVISLIDILQGIDCEdAHLQ------VI 99
Cdd:PTZ00110 129 VVSFEYTSFPDYILKSLKNAGFTEPTPIQVQGWPIALSGRDMIGIAETGSGKTLAFLLPAIVHINAQ-PLLRygdgpiVL 207
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 100 LLAPQRGMAQRAHEQLKSLGRNLNVNATCLGFDTTAENDKIS-----HVLMGTPK---DFLSNIPSDTSRIKMFVLDEAD 171
Cdd:PTZ00110 208 VLAPTRELAEQIREQCNKFGASSKIRNTVAYGGVPKRGQIYAlrrgvEILIACPGrliDFLESNVTNLRRVTYLVLDEAD 287
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 172 EMLSKGFKDQIYEVFRSMPQDVQVVLLSATMPSEVLDVTNRFMRD-PIRILVKKDELTL-EGIRQfYINVQKDEWKFNCL 249
Cdd:PTZ00110 288 RMLDMGFEPQIRKIVSQIRPDRQTLMWSATWPKEVQSLARDLCKEePVHVNVGSLDLTAcHNIKQ-EVFVVEEHEKRGKL 366
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 250 CDLLKT--SRETQALIFCNTRRRVTQLTEQLMSIPIKVSCFHGNMEHNEREDMVKDFNSRNTRVLVTTDLMARGMNIRK- 326
Cdd:PTZ00110 367 KMLLQRimRDGDKILIFVETKKGADFLTKELRLDGWPALCIHGDKKQEERTWVLNEFKTGKSPIMIATDVASRGLDVKDv 446
|
330 340 350
....*....|....*....|....*....|....*.
gi 922580233 327 SLIINYDVSGNMENYMLRNGRQGNFGSKGLPISFFT 362
Cdd:PTZ00110 447 KYVINFDFPNQIEDYVHRIGRTGRAGAKGASYTFLT 482
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
23-388 |
8.04e-40 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 147.75 E-value: 8.04e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 23 DEVVES------FDDMELKEELLRGIYGFGFEKPSAIQKSAVAPCTTGKDVTIQSQAGSGKT---VISLI-DILQGIDCE 92
Cdd:PRK01297 77 DFVVEPqegktrFHDFNLAPELMHAIHDLGFPYCTPIQAQVLGYTLAGHDAIGRAQTGTGKTaafLISIInQLLQTPPPK 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 93 DAHL---QVILLAPQRGMAQRAHEQLKSLGR--NLNVnATCLG---FDTTAENDKISH--VLMGTPK---DFLSNIPSDT 159
Cdd:PRK01297 157 ERYMgepRALIIAPTRELVVQIAKDAAALTKytGLNV-MTFVGgmdFDKQLKQLEARFcdILVATPGrllDFNQRGEVHL 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 160 SRIKMFVLDEADEMLSKGFKDQIYEVFRSMP--QDVQVVLLSATMPSEVLDVTNRFMRDPIRILVKKDELTLEGIRQFYI 237
Cdd:PRK01297 236 DMVEVMVLDEADRMLDMGFIPQVRQIIRQTPrkEERQTLLFSATFTDDVMNLAKQWTTDPAIVEIEPENVASDTVEQHVY 315
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 238 NVQKDEwKFNCLCDLLKTSRETQALIFCNTRRRVTQLTEQLMSIPIKVSCFHGNMEHNEREDMVKDFNSRNTRVLVTTDL 317
Cdd:PRK01297 316 AVAGSD-KYKLLYNLVTQNPWERVMVFANRKDEVRRIEERLVKDGINAAQLSGDVPQHKRIKTLEGFREGKIRVLVATDV 394
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 922580233 318 MARGMNIRK-SLIINYDVSGNMENYMLRNGRQGNFGSKGLPISFFTENDISDLKKIENHYSTRIE-EMPESFL 388
Cdd:PRK01297 395 AGRGIHIDGiSHVINFTLPEDPDDYVHRIGRTGRAGASGVSISFAGEDDAFQLPEIEELLGRKIScEMPPAEL 467
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
28-373 |
6.27e-39 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 144.95 E-value: 6.27e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 28 SFDDMELKEELLRGIYGFGFEKPSAIQKSAVAPCTTGKDVTIQSQAGSGKTVISLIDILQGIDCEDAH------LQVILL 101
Cdd:PRK10590 2 SFDSLGLSPDILRAVAEQGYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQHLITRQPHakgrrpVRALIL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 102 APQRGMAQRAHEQLKSLGRNLNVNATCLgFDTTAENDKISH------VLMGTPK---DFLSNIPSDTSRIKMFVLDEADE 172
Cdd:PRK10590 82 TPTRELAAQIGENVRDYSKYLNIRSLVV-FGGVSINPQMMKlrggvdVLVATPGrllDLEHQNAVKLDQVEILVLDEADR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 173 MLSKGFKDQIYEVFRSMPQDVQVVLLSATMPSEVLDVTNRFMRDPIRILVKKDELTLEGIRQFYINVQKDEwKFNCLCDL 252
Cdd:PRK10590 161 MLDMGFIHDIRRVLAKLPAKRQNLLFSATFSDDIKALAEKLLHNPLEIEVARRNTASEQVTQHVHFVDKKR-KRELLSQM 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 253 LKTSRETQALIFCNTRRRVTQLTEQLMSIPIKVSCFHGNMEHNEREDMVKDFNSRNTRVLVTTDLMARGMNIRK-SLIIN 331
Cdd:PRK10590 240 IGKGNWQQVLVFTRTKHGANHLAEQLNKDGIRSAAIHGNKSQGARTRALADFKSGDIRVLVATDIAARGLDIEElPHVVN 319
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 922580233 332 YDVSGNMENYMLRNGRQGNFGSKGLPISFFTENDISDLKKIE 373
Cdd:PRK10590 320 YELPNVPEDYVHRIGRTGRAAATGEALSLVCVDEHKLLRDIE 361
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
34-220 |
4.45e-38 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 135.78 E-value: 4.45e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 34 LKEELLRGIYGFGFEKPSAIQKSAVAPCTTG--KDVTIQSQAGSGKTVISLIDILQGIDCEDAHLQVILLAPQRGMAQRA 111
Cdd:cd17963 1 LKPELLKGLYAMGFNKPSKIQETALPLILSDppENLIAQSQSGTGKTAAFVLAMLSRVDPTLKSPQALCLAPTRELARQI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 112 HEQLKSLGRNLNVNATCLGFDTTAE-NDKIS-HVLMGTPKDFLSNIPS---DTSRIKMFVLDEADEML-SKGFKDQIYEV 185
Cdd:cd17963 81 GEVVEKMGKFTGVKVALAVPGNDVPrGKKITaQIVIGTPGTVLDWLKKrqlDLKKIKILVLDEADVMLdTQGHGDQSIRI 160
|
170 180 190
....*....|....*....|....*....|....*
gi 922580233 186 FRSMPQDVQVVLLSATMPSEVLDVTNRFMRDPIRI 220
Cdd:cd17963 161 KRMLPRNCQILLFSATFPDSVRKFAEKIAPNANTI 195
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
28-384 |
1.02e-37 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 143.17 E-value: 1.02e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 28 SFDDMELKEELLRGIYGFGFEKPSAIQKSAVAPCTTGKDVTIQSQAGSGKTVISLIDILQGI-------DCEDAHLQVIL 100
Cdd:PRK04537 10 TFSSFDLHPALLAGLESAGFTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVMNRLlsrpalaDRKPEDPRALI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 101 LAPQRGMAQRAHEQLKSLGRNLNVNATCL--GFDTTAENDKISH---VLMGTPK---DFLSNIPSDTSRI-KMFVLDEAD 171
Cdd:PRK04537 90 LAPTRELAIQIHKDAVKFGADLGLRFALVygGVDYDKQRELLQQgvdVIIATPGrliDYVKQHKVVSLHAcEICVLDEAD 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 172 EMLSKGFKDQIYEVFRSMPQDV--QVVLLSATMPSEVLDVTNRFMRDPIRILVKKDELTLEGIRQfYINVQKDEWKFNCL 249
Cdd:PRK04537 170 RMFDLGFIKDIRFLLRRMPERGtrQTLLFSATLSHRVLELAYEHMNEPEKLVVETETITAARVRQ-RIYFPADEEKQTLL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 250 CDLLKTSRETQALIFCNTRRRVTQLTEQLMSIPIKVSCFHGNMEHNEREDMVKDFNSRNTRVLVTTDLMARGMNIRK-SL 328
Cdd:PRK04537 249 LGLLSRSEGARTMVFVNTKAFVERVARTLERHGYRVGVLSGDVPQKKRESLLNRFQKGQLEILVATDVAARGLHIDGvKY 328
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 922580233 329 IINYDVSGNMENYMLRNGRQGNFGSKGLPISFFTENDISDLKKIENHYSTRIEEMP 384
Cdd:PRK04537 329 VYNYDLPFDAEDYVHRIGRTARLGEEGDAISFACERYAMSLPDIEAYIEQKIPVEP 384
|
|
| DEADc_DDX39 |
cd17950 |
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ... |
28-222 |
1.14e-35 |
|
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350708 [Multi-domain] Cd Length: 208 Bit Score: 129.77 E-value: 1.14e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 28 SFDDMELKEELLRGIYGFGFEKPSAIQKSAVAPCTTGKDVTIQSQAGSGKTVISLIDILQGIDCEDAHLQVILLAPQRGM 107
Cdd:cd17950 3 GFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLSTLQQLEPVDGQVSVLVICHTREL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 108 AQRAHEQLKSLGRNL-NVNATC------LGFDTTAENDKISHVLMGTP---KDFLSNIPSDTSRIKMFVLDEADEML-SK 176
Cdd:cd17950 83 AFQISNEYERFSKYMpNVKTAVffggvpIKKDIEVLKNKCPHIVVGTPgriLALVREKKLKLSHVKHFVLDECDKMLeQL 162
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 922580233 177 GFKDQIYEVFRSMPQDVQVVLLSATMPSEVLDVTNRFMRDPIRILV 222
Cdd:cd17950 163 DMRRDVQEIFRATPHDKQVMMFSATLSKEIRPVCKKFMQDPLEIFV 208
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
28-365 |
1.74e-35 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 136.46 E-value: 1.74e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 28 SFDDMELKEELLRGIYGFGFEKPSAIQKSAVAPCTTGKDVTIQSQAGSGKTVISLIDIL--------QGIDcEDAHLQVI 99
Cdd:PLN00206 122 SFSSCGLPPKLLLNLETAGYEFPTPIQMQAIPAALSGRSLLVSADTGSGKTASFLVPIIsrcctirsGHPS-EQRNPLAM 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 100 LLAPQRGMAQRAHEQLKSLGRNLNV-NATCLGFDTTAEN----DKISHVLMGTPK---DFLSNIPSDTSRIKMFVLDEAD 171
Cdd:PLN00206 201 VLTPTRELCVQVEDQAKVLGKGLPFkTALVVGGDAMPQQlyriQQGVELIVGTPGrliDLLSKHDIELDNVSVLVLDEVD 280
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 172 EMLSKGFKDQIYEVFRSMPQDvQVVLLSATMPSEVLDVTNRFMRDPIRILVKKDELTLEGIRQFYINVQKDEWKfNCLCD 251
Cdd:PLN00206 281 CMLERGFRDQVMQIFQALSQP-QVLLFSATVSPEVEKFASSLAKDIILISIGNPNRPNKAVKQLAIWVETKQKK-QKLFD 358
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 252 LLKTSRETQ--ALIFCNTRRRVTQLTEQLMSIP-IKVSCFHGNMEHNEREDMVKDFNSRNTRVLVTTDLMARGMNI-RKS 327
Cdd:PLN00206 359 ILKSKQHFKppAVVFVSSRLGADLLANAITVVTgLKALSIHGEKSMKERREVMKSFLVGEVPVIVATGVLGRGVDLlRVR 438
|
330 340 350
....*....|....*....|....*....|....*...
gi 922580233 328 LIINYDVSGNMENYMLRNGRQGNFGSKGLPISFFTEND 365
Cdd:PLN00206 439 QVIIFDMPNTIKEYIHQIGRASRMGEKGTAIVFVNEED 476
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
42-235 |
4.68e-34 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 125.30 E-value: 4.68e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 42 IYGFGFEKPSAIQKSAVAPCTTG-KDVTIQSQAGSGKTVISLIDILQGIDCEDaHLQVILLAPQRGMAQRAHEQLKSLGR 120
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALEALKRGK-GGRVLVLVPTRELAEQWAEELKKLGP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 121 NLNVNATCL--GFDTTAENDKI----SHVLMGTP---KDFLSNIPSDTSRIKMFVLDEADEMLSKGFKDQIYEVFRSMPQ 191
Cdd:smart00487 80 SLGLKVVGLygGDSKREQLRKLesgkTDILVTTPgrlLDLLENDKLSLSNVDLVILDEAHRLLDGGFGDQLEKLLKLLPK 159
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 922580233 192 DVQVVLLSATMPSEVLDVTNRFMRDPIRILVKkdELTLEGIRQF 235
Cdd:smart00487 160 NVQLLLLSATPPEEIENLLELFLNDPVFIDVG--FTPLEPIEQF 201
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
38-220 |
6.44e-34 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 124.68 E-value: 6.44e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 38 LLRGIYGFGFEKPSAIQKSAVAPCTTGKDVTIQSQAGSGKTVISLIDILQGIDCEDAHLQVILLAPQRGMAQRAHEQLKS 117
Cdd:cd17943 1 VLEGLKAAGFQRPSPIQLAAIPLGLAGHDLIVQAKSGTGKTLVFVVIALESLDLERRHPQVLILAPTREIAVQIHDVFKK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 118 LG---RNLNVNATCLGFDTTAENDKI--SHVLMGTP---KDFLSNIPSDTSRIKMFVLDEADEMLSKGFKDQIYEVFRSM 189
Cdd:cd17943 81 IGkklEGLKCEVFIGGTPVKEDKKKLkgCHIAVGTPgriKQLIELGALNVSHVRLFVLDEADKLMEGSFQKDVNWIFSSL 160
|
170 180 190
....*....|....*....|....*....|.
gi 922580233 190 PQDVQVVLLSATMPSEVLDVTNRFMRDPIRI 220
Cdd:cd17943 161 PKNKQVIAFSATYPKNLDNLLARYMRKPVLV 191
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
29-217 |
4.05e-32 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 120.41 E-value: 4.05e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 29 FDDMELKEELLRGIYGFGFEKPSAIQKSAVAPCTTGKDVTIQSQAGSGKTVISLIDILQGIdCED--AHLQVILlAPQRG 106
Cdd:cd17955 1 FEDLGLSSWLVKQCASLGIKEPTPIQKLCIPEILAGRDVIGGAKTGSGKTAAFALPILQRL-SEDpyGIFALVL-TPTRE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 107 MAQRAHEQLKSLGRNLNVNATCL--GFDTTAEN---DKISHVLMGTP---KDFLSN---IPSDTSRIKMFVLDEADEMLS 175
Cdd:cd17955 79 LAYQIAEQFRALGAPLGLRCCVIvgGMDMVKQAlelSKRPHIVVATPgrlADHLRSsddTTKVLSRVKFLVLDEADRLLT 158
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 922580233 176 KGFKDQIYEVFRSMPQDVQVVLLSATMPSEVLDVTNRFMRDP 217
Cdd:cd17955 159 GSFEDDLATILSALPPKRQTLLFSATLTDALKALKELFGNKP 200
|
|
| DEADc_DDX25 |
cd18048 |
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ... |
26-228 |
3.12e-31 |
|
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350806 [Multi-domain] Cd Length: 229 Bit Score: 118.59 E-value: 3.12e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 26 VESFDDMELKEELLRGIYGFGFEKPSAIQKSAVaPCTTG---KDVTIQSQAGSGKTVISLIDILQGIDCEDAHLQVILLA 102
Cdd:cd18048 17 VKSFEELHLKEELLRGIYAMGFNRPSKIQENAL-PMMLAdppQNLIAQSQSGTGKTAAFVLAMLSRVDALKLYPQCLCLS 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 103 PQRGMAQRAHEQLKSLGR---NLNVNATCLGFDTTAENDKISHVLMGTPKDFLSNIPS----DTSRIKMFVLDEADEMLS 175
Cdd:cd18048 96 PTFELALQTGKVVEEMGKfcvGIQVIYAIRGNRPGKGTDIEAQIVIGTPGTVLDWCFKlrliDVTNISVFVLDEADVMIN 175
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 922580233 176 -KGFKDQIYEVFRSMPQDVQVVLLSATMPSEVLDVTNRFMRDPIRILVKKDELT 228
Cdd:cd18048 176 vQGHSDHSVRVKRSMPKECQMLLFSATFEDSVWAFAERIVPDPNIIKLKKEELT 229
|
|
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
34-218 |
4.34e-31 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 117.68 E-value: 4.34e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 34 LKEELLRGIYGFGFEKPSAIQKSAVAPCTTGKDVTIQSQAGSGKTVISLIDILQGI------DCEDAHLQVILLAPQRGM 107
Cdd:cd17961 1 LDPRLLKAIAKLGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYALPIIQKIlkakaeSGEEQGTRALILVPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 108 AQRAHEQLKSLGRNLNVNATCLGFDTTAENDKISHVLM-------GTPKDFLSNI----PSDTSRIKMFVLDEADEMLSK 176
Cdd:cd17961 81 AQQVSKVLEQLTAYCRKDVRVVNLSASSSDSVQRALLAekpdivvSTPARLLSHLesgsLLLLSTLKYLVIDEADLVLSY 160
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 922580233 177 GFKDQIYEVFRSMPQDVQVVLLSATMPSEVLDVTNRFMRDPI 218
Cdd:cd17961 161 GYEEDLKSLLSYLPKNYQTFLMSATLSEDVEALKKLVLHNPA 202
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
38-222 |
2.35e-30 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 115.38 E-value: 2.35e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 38 LLRGIYGFGFEKPSAIQKSAVaPCTT-GKDVTIQSQAGSGKTVISLIDILQGI--DCEDAHLQVILLAPQRGMAQRAHEQ 114
Cdd:cd17957 1 LLNNLEESGYREPTPIQMQAI-PILLhGRDLLACAPTGSGKTLAFLIPILQKLgkPRKKKGLRALILAPTRELASQIYRE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 115 LKSLGRNLNVNATCL--GFDTTAENDKIS----HVLMGTPK---DFLSNIPSDTSRIKMFVLDEADEMLSKGFKDQIYEV 185
Cdd:cd17957 80 LLKLSKGTGLRIVLLskSLEAKAKDGPKSitkyDILVSTPLrlvFLLKQGPIDLSSVEYLVLDEADKLFEPGFREQTDEI 159
|
170 180 190
....*....|....*....|....*....|....*...
gi 922580233 186 FRSMPQ-DVQVVLLSATMPSEVLDVTNRFMRDPIRILV 222
Cdd:cd17957 160 LAACTNpNLQRSLFSATIPSEVEELARSVMKDPIRIIV 197
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
28-220 |
3.20e-29 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 112.41 E-value: 3.20e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 28 SFDDMELKEELLRGIYGFGFEKPSAIQKSAVAPCTTGKDVTIQSQAGSGKTVISLIDILQGIDCEDAHLQVILLAPQRGM 107
Cdd:cd17954 1 TFKELGVCEELCEACEKLGWKKPTKIQEEAIPVALQGRDIIGLAETGSGKTAAFALPILQALLENPQRFFALVLAPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 108 AQRAHEQLKSLGRNLNVNATCL--GFDTTAENDKIS---HVLMGTP---KDFLSNIPSDTSR-IKMFVLDEADEMLSKGF 178
Cdd:cd17954 81 AQQISEQFEALGSSIGLKSAVLvgGMDMMAQAIALAkkpHVIVATPgrlVDHLENTKGFSLKsLKFLVMDEADRLLNMDF 160
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 922580233 179 KDQIYEVFRSMPQDVQVVLLSATMPSEVLDVTNRFMRDPIRI 220
Cdd:cd17954 161 EPEIDKILKVIPRERTTYLFSATMTTKVAKLQRASLKNPVKI 202
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
38-220 |
5.34e-29 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 111.58 E-value: 5.34e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 38 LLRGIYGFGFEKPSAIQKSAVAPCTTGKDVTIQSQAGSGKTVISLIDILQGI---DCEDAHLQVILLAPQRGMAQRAHEQ 114
Cdd:cd17947 1 LLRALSSLGFTKPTPIQAAAIPLALLGKDICASAVTGSGKTAAFLLPILERLlyrPKKKAATRVLVLVPTRELAMQCFSV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 115 LKSLGRNLNVNaTCL---GFDTT---AENDKISHVLMGTPK---DFLSNIPS-DTSRIKMFVLDEADEMLSKGFKDQIYE 184
Cdd:cd17947 81 LQQLAQFTDIT-FALavgGLSLKaqeAALRARPDIVIATPGrliDHLRNSPSfDLDSIEILVLDEADRMLEEGFADELKE 159
|
170 180 190
....*....|....*....|....*....|....*.
gi 922580233 185 VFRSMPQDVQVVLLSATMPSEVLDVTNRFMRDPIRI 220
Cdd:cd17947 160 ILRLCPRTRQTMLFSATMTDEVKDLAKLSLNKPVRV 195
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
29-373 |
8.51e-29 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 116.22 E-value: 8.51e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 29 FDDMELKEELLRGIYGFGFEKPSAIQKSAVAPCTTGKDVTIQSQAGSGKTVISLID----ILQGIDCEDAHL---QVILL 101
Cdd:PRK04837 10 FSDFALHPQVVEALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFLTAtfhyLLSHPAPEDRKVnqpRALIM 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 102 APQRGMAQRAHEQLKSLGRNLNVNATCL----GFDTT-AENDKISHVLMGTPK---DFLSNIPSDTSRIKMFVLDEADEM 173
Cdd:PRK04837 90 APTRELAVQIHADAEPLAQATGLKLGLAyggdGYDKQlKVLESGVDILIGTTGrliDYAKQNHINLGAIQVVVLDEADRM 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 174 LSKGFKDQIYEVFRSMPQDVQ--VVLLSATMPSEVLDVTNRFMRDPIRILVKKDELTLEGIRQ--FYinvQKDEWKFNCL 249
Cdd:PRK04837 170 FDLGFIKDIRWLFRRMPPANQrlNMLFSATLSYRVRELAFEHMNNPEYVEVEPEQKTGHRIKEelFY---PSNEEKMRLL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 250 CDLLKTSRETQALIFCNTRRRVTQLTEQLMSIPIKVSCFHGNMEHNEREDMVKDFNSRNTRVLVTTDLMARGMNIRK-SL 328
Cdd:PRK04837 247 QTLIEEEWPDRAIIFANTKHRCEEIWGHLAADGHRVGLLTGDVAQKKRLRILEEFTRGDLDILVATDVAARGLHIPAvTH 326
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 922580233 329 IINYDVSGNMENYMLRNGRQGNFGSKGLPISFFTENDISDLKKIE 373
Cdd:PRK04837 327 VFNYDLPDDCEDYVHRIGRTGRAGASGHSISLACEEYALNLPAIE 371
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
28-220 |
8.16e-26 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 103.15 E-value: 8.16e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 28 SFDDMELKEELLRGIYGFGFEKPSAIQKSAVAPCTTGKDVTIQSQAGSGKT---VISLIDILQGidcedaHLQVI----- 99
Cdd:cd17959 2 GFQSMGLSPPLLRAIKKKGYKVPTPIQRKTIPLILDGRDVVAMARTGSGKTaafLIPMIEKLKA------HSPTVgaral 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 100 LLAPQRGMAQRAHEQLKSLGR--NLNVNATCLG------FDTTAENDKIshvLMGTPKDFL---SNIPSDTSRIKMFVLD 168
Cdd:cd17959 76 ILSPTRELALQTLKVTKELGKftDLRTALLVGGdsleeqFEALASNPDI---IIATPGRLLhllVEMNLKLSSVEYVVFD 152
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 922580233 169 EADEMLSKGFKDQIYEVFRSMPQDVQVVLLSATMPSEVLDVTNRFMRDPIRI 220
Cdd:cd17959 153 EADRLFEMGFAEQLHEILSRLPENRQTLLFSATLPKLLVEFAKAGLNEPVLI 204
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
38-220 |
9.74e-26 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 102.63 E-value: 9.74e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 38 LLRGIYGFGFEKPSAIQKSAVAPCTTGKDVTIQSQAGSGKTVISLIDILQGIDCEDAHLQVILLAPQRGMAQRAHEQLKS 117
Cdd:cd17962 1 LSSNLKKAGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRCLTEHRNPSALILTPTRELAVQIEDQAKE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 118 LGRNLNVNATCL---GFDTTAENDKISH---VLMGTPKDFLSNIPSDT---SRIKMFVLDEADEMLSKGFKDQIYEVFRS 188
Cdd:cd17962 81 LMKGLPPMKTALlvgGLPLPPQLYRLQQgvkVIIATPGRLLDILKQSSvelDNIKIVVVDEADTMLKMGFQQQVLDILEN 160
|
170 180 190
....*....|....*....|....*....|..
gi 922580233 189 MPQDVQVVLLSATMPSEVLDVTNRFMRDPIRI 220
Cdd:cd17962 161 ISHDHQTILVSATIPRGIEQLAGQLLQNPVRI 192
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
244-352 |
2.65e-25 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 98.82 E-value: 2.65e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 244 WKFNCLCDLLKTSRETQALIFCNTRRRVtQLTEQLMSIPIKVSCFHGNMEHNEREDMVKDFNSRNTRVLVTTDLMARGMN 323
Cdd:pfam00271 1 EKLEALLELLKKERGGKVLIFSQTKKTL-EAELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLD 79
|
90 100 110
....*....|....*....|....*....|
gi 922580233 324 IRK-SLIINYDVSGNMENYMLRNGRQGNFG 352
Cdd:pfam00271 80 LPDvDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
38-220 |
8.95e-25 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 100.14 E-value: 8.95e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 38 LLRGIYGFGFEKPSAIQKSAVAPCTTGKDVTIQSQAGSGKTVISLIDILQGIDCEdAHLQ------VILLAPQRGMAQRA 111
Cdd:cd17966 1 VMDELKRQGFTEPTAIQAQGWPMALSGRDMVGIAQTGSGKTLAFLLPAIVHINAQ-PPLErgdgpiVLVLAPTRELAQQI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 112 HEQLKSLGRNLNVNATCLgFDTTAENDKIS------HVLMGTPK---DFLSNIPSDTSRIKMFVLDEADEMLSKGFKDQI 182
Cdd:cd17966 80 QQEANKFGGSSRLRNTCV-YGGAPKGPQIRdlrrgvEICIATPGrliDFLDQGKTNLRRVTYLVLDEADRMLDMGFEPQI 158
|
170 180 190
....*....|....*....|....*....|....*...
gi 922580233 183 YEVFRSMPQDVQVVLLSATMPSEVLDVTNRFMRDPIRI 220
Cdd:cd17966 159 RKIVDQIRPDRQTLMWSATWPKEVRRLAEDFLKDYIQV 196
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
28-216 |
1.19e-24 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 100.64 E-value: 1.19e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 28 SFDDMELKEELLRGIYGFGFEKPSAIQKSAVAPCTTGKDVTIQSQAGSGKTVISLIDILQGIDCEDAHL----------Q 97
Cdd:cd17967 1 SFEEAGLRELLLENIKRAGYTKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPIISKLLEDGPPSvgrgrrkaypS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 98 VILLAPQRGMAQRAHEQLKSLGRNLNVNATCL--GFDTTAENDKIS---HVLMGTP---KDFLSNIPSDTSRIKMFVLDE 169
Cdd:cd17967 81 ALILAPTRELAIQIYEEARKFSYRSGVRSVVVygGADVVHQQLQLLrgcDILVATPgrlVDFIERGRISLSSIKFLVLDE 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 922580233 170 ADEMLSKGFKDQIYEVFR--SMPQ--DVQVVLLSATMPSEVLDVTNRFMRD 216
Cdd:cd17967 161 ADRMLDMGFEPQIRKIVEhpDMPPkgERQTLMFSATFPREIQRLAADFLKN 211
|
|
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
39-222 |
1.40e-24 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 99.67 E-value: 1.40e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 39 LRGIYGFGFEKPSAIQKSAVAPCTTGKDVTIQSQAGSGKTVISLIDILQGIDCE----DAHLQVILLAPQRGMAQRAHEQ 114
Cdd:cd17941 2 LKGLKEAGFIKMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPLLEKLYRErwtpEDGLGALIISPTRELAMQIFEV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 115 LKSLGRNLNVNATCL--GFDTTAENDKISH--VLMGTPKDFLSNI---PS-DTSRIKMFVLDEADEMLSKGFKDQIYEVF 186
Cdd:cd17941 82 LRKVGKYHSFSAGLIigGKDVKEEKERINRmnILVCTPGRLLQHMdetPGfDTSNLQMLVLDEADRILDMGFKETLDAIV 161
|
170 180 190
....*....|....*....|....*....|....*.
gi 922580233 187 RSMPQDVQVVLLSATMPSEVLDVTNRFMRDPIRILV 222
Cdd:cd17941 162 ENLPKSRQTLLFSATQTKSVKDLARLSLKNPEYISV 197
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
38-220 |
1.12e-22 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 94.57 E-value: 1.12e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 38 LLRGIYGFGFEKPSAIQKSAVAPCTTGKDVTIQSQAGSGKT---VISLIDILQGIDCE--DAHLQVILLAPQRGMAQRAH 112
Cdd:cd17960 1 ILDVVAELGFTSMTPVQAATIPLFLSNKDVVVEAVTGSGKTlafLIPVLEILLKRKANlkKGQVGALIISPTRELATQIY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 113 EQLKSL--GRNLNVNATCL-GFDTTAENDKI-----SHVLMGTP---KDFLSNI--PSDTSRIKMFVLDEADEMLSKGFK 179
Cdd:cd17960 81 EVLQSFleHHLPKLKCQLLiGGTNVEEDVKKfkrngPNILVGTPgrlEELLSRKadKVKVKSLEVLVLDEADRLLDLGFE 160
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 922580233 180 DQIYEVFRSMPQDVQVVLLSATMPSEVLDVTNRFMRDPIRI 220
Cdd:cd17960 161 ADLNRILSKLPKQRRTGLFSATQTDAVEELIKAGLRNPVRV 201
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
53-215 |
4.72e-22 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 92.99 E-value: 4.72e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 53 IQKSAVAPCTTGKDVTIQSQAGSGKT---VISLIDILQGIDCEDAH---LQVILLAPQRGMAQRAHEQLKSLGRNLNVNA 126
Cdd:cd17944 16 IQVKTFHPVYSGKDLIAQARTGTGKTfsfAIPLIEKLQEDQQPRKRgraPKVLVLAPTRELANQVTKDFKDITRKLSVAC 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 127 TCLGFDTTAENDKISH---VLMGTP---KDFLSNIPSDTSRIKMFVLDEADEMLSKGFKDQIYEV----FRSMPQD-VQV 195
Cdd:cd17944 96 FYGGTPYQQQIFAIRNgidILVGTPgriKDHLQNGRLDLTKLKHVVLDEVDQMLDMGFAEQVEEIlsvsYKKDSEDnPQT 175
|
170 180
....*....|....*....|
gi 922580233 196 VLLSATMPSEVLDVTNRFMR 215
Cdd:cd17944 176 LLFSATCPDWVYNVAKKYMK 195
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
34-215 |
5.16e-22 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 93.03 E-value: 5.16e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 34 LKEELLRGIYGFGFEKPSAIQKSAVAPC-TTGKDVTIQSQAGSGKTVISLIDILQGI-----DCEDAHLQVILLAPQRGM 107
Cdd:cd17964 1 LDPSLLKALTRMGFETMTPVQQKTLKPIlSTGDDVLARAKTGTGKTLAFLLPAIQSLlntkpAGRRSGVSALIISPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 108 AQRAHEQLKSL---GRNLNVnATCLGFDTTAENDKI-----SHVLMGTP---KDFLSN--IPSDTSRIKMFVLDEADEML 174
Cdd:cd17964 81 ALQIAAEAKKLlqgLRKLRV-QSAVGGTSRRAELNRlrrgrPDILVATPgrlIDHLENpgVAKAFTDLDYLVLDEADRLL 159
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 922580233 175 SKGFKDQIYEVFRSMPQ----DVQVVLLSATMPSEVLDVTNRFMR 215
Cdd:cd17964 160 DMGFRPDLEQILRHLPEknadPRQTLLFSATVPDEVQQIARLTLK 204
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
34-220 |
5.74e-22 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 93.21 E-value: 5.74e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 34 LKEELLRGIYGFGFEKPSAIQKSAVAPCTTGKDVTIQSQAGSGKTVISLIDILQGI------DCEDAHLQVILlAPQRGM 107
Cdd:cd17953 19 LSEKVLDLIKKLGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPMFRHIkdqrpvKPGEGPIGLIM-APTREL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 108 AQRAHEQLKSLGRNLNVNATCLgFDTTAENDKIS------HVLMGTPK---DFL---SNIPSDTSRIKMFVLDEADEMLS 175
Cdd:cd17953 98 ALQIYVECKKFSKALGLRVVCV-YGGSGISEQIAelkrgaEIVVCTPGrmiDILtanNGRVTNLRRVTYVVLDEADRMFD 176
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 922580233 176 KGFKDQIYEVFRSMPQDVQVVLLSATMPSEVLDVTNRFMRDPIRI 220
Cdd:cd17953 177 MGFEPQIMKIVNNIRPDRQTVLFSATFPRKVEALARKVLHKPIEI 221
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
29-217 |
9.79e-22 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 92.00 E-value: 9.79e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 29 FDDMELKEELLRGIYGFGFEKPSAIQKSAVAPCTTGKDVTIQSQAGSGKTVISLIDILQGIdcedahlQVILLAPQRGMA 108
Cdd:cd17938 1 FEELGVMPELIKAVEELDWLLPTDIQAEAIPLILGGGDVLMAAETGSGKTGAFCLPVLQIV-------VALILEPSRELA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 109 QRAHEQLKSLGRNLN----VNATCLGFDTTAENDKI----SHVLMGTP---KDFLSNIPSDTSRIKMFVLDEADEMLSKG 177
Cdd:cd17938 74 EQTYNCIENFKKYLDnpklRVALLIGGVKAREQLKRlesgVDIVVGTPgrlEDLIKTGKLDLSSVRFFVLDEADRLLSQG 153
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 922580233 178 FKDQIYEVFRSMPQ------DVQVVLLSATMPS-EVLDVTNRFMRDP 217
Cdd:cd17938 154 NLETINRIYNRIPKitsdgkRLQVIVCSATLHSfEVKKLADKIMHFP 200
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
45-220 |
1.42e-21 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 91.88 E-value: 1.42e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 45 FGFEKPSAIQKSAVAPCTTGKDVTIQSQAGSGKTVISLIDILQGIDCEDAHLQ------VILLAPQRGMAQRAHEQLKSL 118
Cdd:cd17949 9 MGIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIIQRLLSLEPRVDrsdgtlALVLVPTRELALQIYEVLEKL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 119 GR---NLNVNATCLGFDTTAENDKIS---HVLMGTPK---DFLSNIPS-DTSRIKMFVLDEADEMLSKGFKDQIYEVFR- 187
Cdd:cd17949 89 LKpfhWIVPGYLIGGEKRKSEKARLRkgvNILIATPGrllDHLKNTQSfDVSNLRWLVLDEADRLLDMGFEKDITKILEl 168
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 922580233 188 ------------SMPQDVQVVLLSATMPSEVLDVTNRFMRDPIRI 220
Cdd:cd17949 169 lddkrskaggekSKPSRRQTVLVSATLTDGVKRLAGLSLKDPVYI 213
|
|
| DEADc_DDX19 |
cd18047 |
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ... |
27-217 |
6.04e-21 |
|
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350805 [Multi-domain] Cd Length: 205 Bit Score: 90.16 E-value: 6.04e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 27 ESFDDMELKEELLRGIYGFGFEKPSAIQKSAVaPCTTG---KDVTIQSQAGSGKTVISLIDILQGIDCEDAHLQVILLAP 103
Cdd:cd18047 1 KSFEELRLKPQLLQGVYAMGFNRPSKIQENAL-PLMLAeppQNLIAQSQSGTGKTAAFVLAMLSQVEPANKYPQCLCLSP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 104 QRGMAQRAHEQLKSLGR---NLNVNATCLGFDTTAENDKISHVLMGTPKDFLSNIPS----DTSRIKMFVLDEADEML-S 175
Cdd:cd18047 80 TYELALQTGKVIEQMGKfypELKLAYAVRGNKLERGQKISEQIVIGTPGTVLDWCSKlkfiDPKKIKVFVLDEADVMIaT 159
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 922580233 176 KGFKDQIYEVFRSMPQDVQVVLLSATMPSEVLDVTNRFMRDP 217
Cdd:cd18047 160 QGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDP 201
|
|
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
21-215 |
2.06e-19 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 86.94 E-value: 2.06e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 21 NYDEV-VE-----------SFDDMELKEELLRGIYGFGFEKPSAIQKSAVAPCTTGKDVTIQSQAGSGKTVISLIDILQ- 87
Cdd:cd18052 25 KYDEIpVEvtgrnpppailTFEEANLCETLLKNIRKAGYEKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPVLTg 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 88 ----GID----CEDAHLQVILLAPQRGMAQRAHEQLKSLGRNLNVNATCL--GFDTTAENDKIS---HVLMGTP---KDF 151
Cdd:cd18052 105 mmkeGLTassfSEVQEPQALIVAPTRELANQIFLEARKFSYGTCIRPVVVygGVSVGHQIRQIEkgcHILVATPgrlLDF 184
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 922580233 152 LSNIPSDTSRIKMFVLDEADEMLSKGFKDQIYEV--FRSMP--QDVQVVLLSATMPSEVLDVTNRFMR 215
Cdd:cd18052 185 IGRGKISLSKLKYLILDEADRMLDMGFGPEIRKLvsEPGMPskEDRQTLMFSATFPEEIQRLAAEFLK 252
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
47-220 |
9.25e-19 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 84.68 E-value: 9.25e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 47 FEKPSAIQKSAVAPCTTGKDVTIQSQAGSGKTVISLIDILQGIDcEDAHLQ------VILLAPQRGMAQRAHEQLKSLGR 120
Cdd:cd18049 44 FTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHIN-HQPFLErgdgpiCLVLAPTRELAQQVQQVAAEYGR 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 121 NLNVNATCLgFDTTAENDKIS------HVLMGTPK---DFLSNIPSDTSRIKMFVLDEADEMLSKGFKDQIYEVFRSMPQ 191
Cdd:cd18049 123 ACRLKSTCI-YGGAPKGPQIRdlergvEICIATPGrliDFLEAGKTNLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRP 201
|
170 180
....*....|....*....|....*....
gi 922580233 192 DVQVVLLSATMPSEVLDVTNRFMRDPIRI 220
Cdd:cd18049 202 DRQTLMWSATWPKEVRQLAEDFLKDYIHI 230
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
38-220 |
1.14e-18 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 83.28 E-value: 1.14e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 38 LLRGIYGFGFEKPSAIQKSAVAPCTTGKDVTIQSQAGSGKTVISLIDILQGIDCEDAHLQ------VILLAPQRGMAQRA 111
Cdd:cd17958 1 IMKEIKKQGFEKPSPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLPGFIHLDLQPIPREqrngpgVLVLTPTRELALQI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 112 HEQLKSLGRNlNVNATCL--GFDTTAENDKISH---VLMGTP---KDFLSNIPSDTSRIKMFVLDEADEMLSKGFKDQIY 183
Cdd:cd17958 81 EAECSKYSYK-GLKSVCVygGGNRNEQIEDLSKgvdIIIATPgrlNDLQMNNVINLKSITYLVLDEADRMLDMGFEPQIR 159
|
170 180 190
....*....|....*....|....*....|....*..
gi 922580233 184 EVFRSMPQDVQVVLLSATMPSEVLDVTNRFMRDPIRI 220
Cdd:cd17958 160 KILLDIRPDRQTIMTSATWPDGVRRLAQSYLKDPMIV 196
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
38-220 |
1.35e-18 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 83.91 E-value: 1.35e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 38 LLRGIYGFGFEKPSAIQKSAVAPCTTGKDVTIQSQAGSGKTVISLIDILQGI---------DCEDAHLQVIlLAPQRGMA 108
Cdd:cd17945 1 LLRVIRKLGYKEPTPIQRQAIPIGLQNRDIIGIAETGSGKTAAFLIPLLVYIsrlppldeeTKDDGPYALI-LAPTRELA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 109 QRAHEQLKSLGRNLNVNATCL--GFDTTAENDKIS---HVLMGTP---KDFLSNIPSDTSRIKMFVLDEADEMLSKGFKD 180
Cdd:cd17945 80 QQIEEETQKFAKPLGIRVVSIvgGHSIEEQAFSLRngcEILIATPgrlLDCLERRLLVLNQCTYVVLDEADRMIDMGFEP 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 181 QIYEVFRSMPQDV--------------------QVVLLSATMPSEVLDVTNRFMRDPIRI 220
Cdd:cd17945 160 QVTKILDAMPVSNkkpdteeaeklaasgkhryrQTMMFTATMPPAVEKIAKGYLRRPVVV 219
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
47-220 |
1.57e-18 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 84.68 E-value: 1.57e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 47 FEKPSAIQKSAVAPCTTGKDVTIQSQAGSGKTVISLIDILQGIDcEDAHLQ------VILLAPQRGMAQRAHEQLKSLGR 120
Cdd:cd18050 82 FKEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHIN-HQPYLErgdgpiCLVLAPTRELAQQVQQVADDYGK 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 121 NLNVNATCLgFDTTAENDKIS------HVLMGTPK---DFLSNIPSDTSRIKMFVLDEADEMLSKGFKDQIYEVFRSMPQ 191
Cdd:cd18050 161 SSRLKSTCI-YGGAPKGPQIRdlergvEICIATPGrliDFLEAGKTNLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRP 239
|
170 180
....*....|....*....|....*....
gi 922580233 192 DVQVVLLSATMPSEVLDVTNRFMRDPIRI 220
Cdd:cd18050 240 DRQTLMWSATWPKEVRQLAEDFLRDYVQI 268
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
273-352 |
3.68e-18 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 78.41 E-value: 3.68e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 273 QLTEQLMSIPIKVSCFHGNMEHNEREDMVKDFNSRNTRVLVTTDLMARGMNIRK-SLIINYDVSGNMENYMLRNGRQGNF 351
Cdd:smart00490 2 ELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGvDLVIIYDLPWSPASYIQRIGRAGRA 81
|
.
gi 922580233 352 G 352
Cdd:smart00490 82 G 82
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
38-220 |
5.66e-18 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 81.31 E-value: 5.66e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 38 LLRGIYGFGFEKPSAIQKSAVAPCTTGKDVTIQSQAGSGKTVI----SLIDILQGIDCE--DAHLQVILlAPQRGMAQRA 111
Cdd:cd17952 1 LLNAIRKQEYEQPTPIQAQALPVALSGRDMIGIAKTGSGKTAAfiwpMLVHIMDQRELEkgEGPIAVIV-APTRELAQQI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 112 HEQLKSLGRNLNVNATCL-GFDTTAENDKI----SHVLMGTPK---DFLSNIPSDTSRIKMFVLDEADEMLSKGFKDQIY 183
Cdd:cd17952 80 YLEAKKFGKAYNLRVVAVyGGGSKWEQAKAlqegAEIVVATPGrliDMVKKKATNLQRVTYLVLDEADRMFDMGFEYQVR 159
|
170 180 190
....*....|....*....|....*....|....*..
gi 922580233 184 EVFRSMPQDVQVVLLSATMPSEVLDVTNRFMRDPIRI 220
Cdd:cd17952 160 SIVGHVRPDRQTLLFSATFKKKIEQLARDILSDPIRV 196
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
39-208 |
3.90e-16 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 76.25 E-value: 3.90e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 39 LRGIYGFGFEKPSAIQKSAVAPCTTGKDVTIQSQAGSGKTV---ISLIDILQGIDCEDAH-LQVILLAPQRGMAQRAHEQ 114
Cdd:cd17942 2 LKAIEEMGFTKMTEIQAKSIPPLLEGRDVLGAAKTGSGKTLaflIPAIELLYKLKFKPRNgTGVIIISPTRELALQIYGV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 115 LKSLGRNLNVNATCL--GFDTTAENDKIS---HVLMGTPK---DFLSNIPSDTSR-IKMFVLDEADEMLSKGFKDQIYEV 185
Cdd:cd17942 82 AKELLKYHSQTFGIVigGANRKAEAEKLGkgvNILVATPGrllDHLQNTKGFLYKnLQCLIIDEADRILEIGFEEEMRQI 161
|
170 180
....*....|....*....|...
gi 922580233 186 FRSMPQDVQVVLLSATMPSEVLD 208
Cdd:cd17942 162 IKLLPKRRQTMLFSATQTRKVED 184
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
64-201 |
4.38e-15 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 72.05 E-value: 4.38e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 64 GKDVTIQSQAGSGKTVISLIDILQGIDceDAHLQVILLAPQRGMAQRAHEQLKSLGRNLNVNATCLGFDTTAENDKI--- 140
Cdd:cd00046 1 GENVLITAPTGSGKTLAALLAALLLLL--KKGKKVLVLVPTKALALQTAERLRELFGPGIRVAVLVGGSSAEEREKNklg 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 922580233 141 -SHVLMGTPKDFLSNI----PSDTSRIKMFVLDEADEMLSKGFKDQIYE--VFRSMPQDVQVVLLSAT 201
Cdd:cd00046 79 dADIIIATPDMLLNLLlredRLFLKDLKLIIVDEAHALLIDSRGALILDlaVRKAGLKNAQVILLSAT 146
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
26-218 |
5.50e-15 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 73.92 E-value: 5.50e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 26 VESFDDMELKEELLRGIYGFGFEKPSAIQKSAVAPCTTGKDVTIQSQAGSGKTVISLIDILQGI---DCEDAHLQV---- 98
Cdd:cd18051 20 IETFSDLDLGEIIRNNIELARYTKPTPVQKHAIPIIKSKRDLMACAQTGSGKTAAFLLPILSQIyeqGPGESLPSEsgyy 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 99 ---------ILLAPQRGMAQRAHEQLKSLGRNLNVNATCL--GFDTTA---ENDKISHVLMGTPK---DFLSNIPSDTSR 161
Cdd:cd18051 100 grrkqyplaLVLAPTRELASQIYDEARKFAYRSRVRPCVVygGADIGQqmrDLERGCHLLVATPGrlvDMLERGKIGLDY 179
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 922580233 162 IKMFVLDEADEMLSKGFKDQIYEVFR--SMPQ--DVQVVLLSATMPSEVLDVTNRFMRDPI 218
Cdd:cd18051 180 CKYLVLDEADRMLDMGFEPQIRRIVEqdTMPPtgERQTLMFSATFPKEIQMLARDFLDNYI 240
|
|
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
38-226 |
3.19e-14 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 71.50 E-value: 3.19e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 38 LLRGIYGFGFEKPSAIQKSAVAPC-TTGKDVTIQSQAGSGKTVISLIDILQGI---------DCEDAHLQVILLAPQRGM 107
Cdd:cd17946 1 ILRALADLGFSEPTPIQALALPAAiRDGKDVIGAAETGSGKTLAFGIPILERLlsqkssngvGGKQKPLRALILTPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 108 AQRAHEQLKSLGRNLNVNATCL--GFDTTAEN---DKISHVLMGTPKDFLSNIPSDTS------RIKMFVLDEADEMLSK 176
Cdd:cd17946 81 AVQVKDHLKAIAKYTNIKIASIvgGLAVQKQErllKKRPEIVVATPGRLWELIQEGNEhlanlkSLRFLVLDEADRMLEK 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 922580233 177 G-FKD--QIYEVFRSMPQDV----QVVLLSATMpSEVLDVTNRFMRDPIRILVKKDE 226
Cdd:cd17946 161 GhFAEleKILELLNKDRAGKkrkrQTFVFSATL-TLDHQLPLKLNSKKKKKKKEKKQ 216
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
38-212 |
4.50e-14 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 70.86 E-value: 4.50e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 38 LLRGIYGFGFEKPSAIQKSAVAPCTTGKDVTIQSQAGSGKTVISLIDILQGI-----DCEDA--HLQVILLAPQRGMAQR 110
Cdd:cd17948 1 LVEILQRQGITKPTTVQKQGIPSILRGRNTLCAAETGSGKTLTYLLPIIQRLlryklLAEGPfnAPRGLVITPSRELAEQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 111 AHEQLKSLGRNLNVNATCLGFDTTAENDKISH-----VLMGTP----KDFLSNIPSdTSRIKMFVLDEADEMLSKGFKDQ 181
Cdd:cd17948 81 IGSVAQSLTEGLGLKVKVITGGRTKRQIRNPHfeevdILVATPgalsKLLTSRIYS-LEQLRHLVLDEADTLLDDSFNEK 159
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 922580233 182 IYEVFRSMP-------------QDVQVVLLSATMPSEVLDVTNR 212
Cdd:cd17948 160 LSHFLRRFPlasrrsentdgldPGTQLVLVSATMPSGVGEVLSK 203
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
181-386 |
1.15e-11 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 66.28 E-value: 1.15e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 181 QIYEVFRSMPqdvqVVLLSATMpsevlDVTNRfmRDPIRILVKKDELTLEG------IRqfYINVQKDE-----WKFncl 249
Cdd:PRK11057 167 QLRQRFPTLP----FMALTATA-----DDTTR--QDIVRLLGLNDPLIQISsfdrpnIR--YTLVEKFKpldqlMRY--- 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 250 cdlLKTSRETQALIFCNTRRRVTQLTEQLMSIPIKVSCFHGNMEHNEREDMVKDFNSRNTRVLVTTdlMARGMNIRKS-- 327
Cdd:PRK11057 231 ---VQEQRGKSGIIYCNSRAKVEDTAARLQSRGISAAAYHAGLDNDVRADVQEAFQRDDLQIVVAT--VAFGMGINKPnv 305
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 922580233 328 -LIINYDVSGNMENYMLRNGRQGNfgsKGLP---ISFFTENDISDLKKIenhystrIEEMPES 386
Cdd:PRK11057 306 rFVVHFDIPRNIESYYQETGRAGR---DGLPaeaMLFYDPADMAWLRRC-------LEEKPAG 358
|
|
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
113-341 |
1.50e-11 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 65.55 E-value: 1.50e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 113 EQLKSLGrnlnVNATCL-GFDTTAENDKI-SHVLMGTPK------------DFLSNIPSdtSRIKMFVLDEA-------- 170
Cdd:COG0514 75 DALRAAG----IRAAFLnSSLSAEERREVlRALRAGELKllyvaperllnpRFLELLRR--LKISLFAIDEAhcisqwgh 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 171 D---EMLskgfkdQIYEVFRSMPqDVQVVLLSATMPSEV-LDVTNRF-MRDPIRIL--VKKDELTLEgIRQFYINvQKDE 243
Cdd:COG0514 149 DfrpDYR------RLGELRERLP-NVPVLALTATATPRVrADIAEQLgLEDPRVFVgsFDRPNLRLE-VVPKPPD-DKLA 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 244 WkfncLCDLLKTSRETQALIFCNTRRRVTQLTEQLMSIPIKVSCFHGNMEHNEREDMVKDFNSRNTRVLVTTdlMARGMN 323
Cdd:COG0514 220 Q----LLDFLKEHPGGSGIVYCLSRKKVEELAEWLREAGIRAAAYHAGLDAEEREANQDRFLRDEVDVIVAT--IAFGMG 293
|
250 260
....*....|....*....|.
gi 922580233 324 IRKS---LIINYDVSGNMENY 341
Cdd:COG0514 294 IDKPdvrFVIHYDLPKSIEAY 314
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
248-349 |
5.01e-11 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 59.91 E-value: 5.01e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 248 CLCDLLKTSRETQ----ALIFCNTRRRVTQLTEQLMSIPIKVSCFHGNMEHNEREDMVKDFNSRNTRVLVTTdlMARGMN 323
Cdd:cd18794 16 EKLDLLKRIKVEHlggsGIIYCLSRKECEQVAARLQSKGISAAAYHAGLEPSDRRDVQRKWLRDKIQVIVAT--VAFGMG 93
|
90 100
....*....|....*....|....*....
gi 922580233 324 IRKS---LIINYDVSGNMENYMLRNGRQG 349
Cdd:cd18794 94 IDKPdvrFVIHYSLPKSMESYYQESGRAG 122
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
38-220 |
9.27e-11 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 60.82 E-value: 9.27e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 38 LLRGIYGFGFEKPSAIQKSAVAPCTTGKDVTIQSQAGSGKT-VISLIDILQGIDcEDAHLQVI--------LLAPQRGMA 108
Cdd:cd17951 1 ILKGLKKKGIKKPTPIQMQGLPTILSGRDMIGIAFTGSGKTlVFTLPLIMFALE-QEKKLPFIkgegpyglIVCPSRELA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 109 QRAHEQLKSLGRNLNVNA-----TCL---GFDTTAENDKIS---HVLMGTP---KDFLSNIPSDTSRIKMFVLDEADEML 174
Cdd:cd17951 80 RQTHEVIEYYCKALQEGGypqlrCLLcigGMSVKEQLEVIRkgvHIVVATPgrlMDMLNKKKINLDICRYLCLDEADRMI 159
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 922580233 175 SKGFKDQIYEVFRSMPQDVQVVLLSATMPSEVLDVTNRFMRDPIRI 220
Cdd:cd17951 160 DMGFEEDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTV 205
|
|
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
49-220 |
1.83e-09 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 57.77 E-value: 1.83e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 49 KPSAIQKSAV----------APCTTGKDV------TIQSQAGSGKT---VISLIDILQGIDCED--------------AH 95
Cdd:cd17965 30 KPSPIQTLAIkkllktlmrkVTKQTSNEEpklevfLLAAETGSGKTlayLAPLLDYLKRQEQEPfeeaeeeyesakdtGR 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 96 LQVILLAPQRGMAQRAHEQLKSLGRNLNVNATCLGFDTTAENDKISH-------VLMGTPKDFLSNIPSDT---SRIKMF 165
Cdd:cd17965 110 PRSVILVPTHELVEQVYSVLKKLSHTVKLGIKTFSSGFGPSYQRLQLafkgridILVTTPGKLASLAKSRPkilSRVTHL 189
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 922580233 166 VLDEADEMLSKGFKDQIYEVFRSMPQDVQVVLLSATMPSEVLDVTNRFMRDPIRI 220
Cdd:cd17965 190 VVDEADTLFDRSFLQDTTSIIKRAPKLKHLILCSATIPKEFDKTLRKLFPDVVRI 244
|
|
| Cas3 |
COG1203 |
CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; ... |
166-315 |
6.07e-09 |
|
CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; CRISPR-Cas type I system-associated endonuclease/helicase Cas3 is part of the Pathway/BioSystem: CRISPR-Cas system
Pssm-ID: 440816 [Multi-domain] Cd Length: 535 Bit Score: 57.78 E-value: 6.07e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 166 VLDEAD----EMLSkgfkdQIYEVFRSMPQ-DVQVVLLSATMPSEVLDvtnrFMRDPIRILVKKDELTLEGIRQFY---I 237
Cdd:COG1203 273 ILDEVQayppYMLA-----LLLRLLEWLKNlGGSVILMTATLPPLLRE----ELLEAYELIPDEPEELPEYFRAFVrkrV 343
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 238 NVQKDEWKFNCLCDLLKT--SRETQALIFCNTRRRVTQLTEQL--MSIPIKVSCFHGNM--EH-NEREDMVKD-FNSRNT 309
Cdd:COG1203 344 ELKEGPLSDEELAELILEalHKGKSVLVIVNTVKDAQELYEALkeKLPDEEVYLLHSRFcpADrSEIEKEIKErLERGKP 423
|
....*.
gi 922580233 310 RVLVTT 315
Cdd:COG1203 424 CILVST 429
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
26-278 |
1.52e-08 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 56.44 E-value: 1.52e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 26 VESFDDMELKEELLRgiygFGFEK--PSaiQKSAVAPC-TTGKDVTIQSQAGSGKTVISLIDILQGIDcedAHLQVILLA 102
Cdd:COG1204 3 VAELPLEKVIEFLKE----RGIEElyPP--QAEALEAGlLEGKNLVVSAPTASGKTLIAELAILKALL---NGGKALYIV 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 103 PQRGMAQRAHEQLKSLGRNLNVN--ATCLGFDTTAENDKISHVLMGTPKDFLS---NIPSDTSRIKMFVLDEA----DEm 173
Cdd:COG1204 74 PLRALASEKYREFKRDFEELGIKvgVSTGDYDSDDEWLGRYDILVATPEKLDSllrNGPSWLRDVDLVVVDEAhlidDE- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 174 lSKGFkdqIYEV----FRSMPQDVQVVLLSATMP-----SEVLD---VTNRFMRDPIRILVKKDeltleGIRQF---YIN 238
Cdd:COG1204 153 -SRGP---TLEVllarLRRLNPEAQIVALSATIGnaeeiAEWLDaelVKSDWRPVPLNEGVLYD-----GVLRFddgSRR 223
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 922580233 239 VQKDEWKFnclcdLLKTSRE-TQALIFCNTRRRVTQLTEQL 278
Cdd:COG1204 224 SKDPTLAL-----ALDLLEEgGQVLVFVSSRRDAESLAKKL 259
|
|
| PRK01172 |
PRK01172 |
ATP-dependent DNA helicase; |
54-349 |
6.46e-08 |
|
ATP-dependent DNA helicase;
Pssm-ID: 100801 [Multi-domain] Cd Length: 674 Bit Score: 54.50 E-value: 6.46e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 54 QKSAVAPCTTGKDVTIQSQAGSGKTVISLIDILQGIDcedAHLQVILLAPQRGMAQRAHEQLKSLgRNLNVNAT-CLG-F 131
Cdd:PRK01172 27 QRMAIEQLRKGENVIVSVPTAAGKTLIAYSAIYETFL---AGLKSIYIVPLRSLAMEKYEELSRL-RSLGMRVKiSIGdY 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 132 DTTAENDKISHVLMGTPKDFLSNIPSDTSRIKMFVLDEADEMLSKGFKDQ------IYEVFRSMPQDVQVVLLSATMP-- 203
Cdd:PRK01172 103 DDPPDFIKRYDVVILTSEKADSLIHHDPYIINDVGLIVADEIHIIGDEDRgptletVLSSARYVNPDARILALSATVSna 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 204 ---SEVLD---VTNRFMRDPIRI-LVKKDELTLEGIRQFYInvqkdewkfnclcDLLKTSRET-----QALIFCNTRRRV 271
Cdd:PRK01172 183 nelAQWLNaslIKSNFRPVPLKLgILYRKRLILDGYERSQV-------------DINSLIKETvndggQVLVFVSSRKNA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 272 TQLTEQLMS-------------------------IPIKVSCFHGNMEHNEREDMVKDFNSRNTRVLVTTDLMARGMNIRK 326
Cdd:PRK01172 250 EDYAEMLIQhfpefndfkvssennnvyddslnemLPHGVAFHHAGLSNEQRRFIEEMFRNRYIKVIVATPTLAAGVNLPA 329
|
330 340 350
....*....|....*....|....*....|....*
gi 922580233 327 SLIINYDVS----------GNME-NYML-RNGRQG 349
Cdd:PRK01172 330 RLVIVRDITrygnggirylSNMEiKQMIgRAGRPG 364
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
245-337 |
1.19e-07 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 50.17 E-value: 1.19e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 245 KFNCLCDLLKTSRETQ--ALIFCNTRRRVTQLTEQLMSIPIKVSCFHGNMEHNEREDMVKDFNSRNT--RVLVTTDLMAR 320
Cdd:cd18793 12 KLEALLELLEELREPGekVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDirVFLLSTKAGGV 91
|
90
....*....|....*...
gi 922580233 321 GMN-IRKSLIINYDVSGN 337
Cdd:cd18793 92 GLNlTAANRVILYDPWWN 109
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
74-317 |
2.32e-07 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 52.72 E-value: 2.32e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 74 GSGKTVISLIDILQgidcEDAHLQVILLAPQRGMAQRAHEQLKSLgrnlnvnaTCLGFDTTAENDKISHVLMGTPKDFLS 153
Cdd:COG1061 110 GTGKTVLALALAAE----LLRGKRVLVLVPRRELLEQWAEELRRF--------LGDPLAGGGKKDSDAPITVATYQSLAR 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 154 NIPSDT--SRIKMFVLDEADEMLSKGFKdqiyEVFRSMPqDVQVVLLSAT--------MPSEVLDVT------NRFMRD- 216
Cdd:COG1061 178 RAHLDElgDRFGLVIIDEAHHAGAPSYR----RILEAFP-AAYRLGLTATpfrsdgreILLFLFDGIvyeyslKEAIEDg 252
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 217 ---PIRILVKKDELTLEGIRQFYIN-------VQKDEWKFNCLCDLLKTSRET-QALIFCNTRRRVTQLTEQLMSIPIKV 285
Cdd:COG1061 253 ylaPPEYYGIRVDLTDERAEYDALSerlrealAADAERKDKILRELLREHPDDrKTLVFCSSVDHAEALAELLNEAGIRA 332
|
250 260 270
....*....|....*....|....*....|..
gi 922580233 286 SCFHGNMEHNEREDMVKDFNSRNTRVLVTTDL 317
Cdd:COG1061 333 AVVTGDTPKKEREEILEAFRDGELRILVTVDV 364
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
74-203 |
2.33e-07 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 50.34 E-value: 2.33e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 74 GSGKTVISLIDILQGIDCEDAhlQVILLAPQRGMAQRAHEQLKSLGRNLNVNATCLGFDTTAENDKI--SHVLMGTPKDF 151
Cdd:cd17921 27 SSGKTLIAELAILRALATSGG--KAVYIAPTRALVNQKEADLRERFGPLGKNVGLLTGDPSVNKLLLaeADILVATPEKL 104
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 152 ---LSNIPSD-TSRIKMFVLDEAdEMLSKGFKDQIYEV----FRSMPQDVQVVLLSATMP 203
Cdd:cd17921 105 dllLRNGGERlIQDVRLVVVDEA-HLIGDGERGVVLELllsrLLRINKNARFVGLSATLP 163
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
25-315 |
6.54e-06 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 48.29 E-value: 6.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 25 VVESFDDmELKEELLRGIYGFGFEKPSAIQKSAVAPCTTGKDVTIQSQAGSGKTVISLIDILQGIdCEDAHLQVILLAPQ 104
Cdd:COG1205 33 RYAPWPD-WLPPELRAALKKRGIERLYSHQAEAIEAARAGKNVVIATPTASGKSLAYLLPVLEAL-LEDPGATALYLYPT 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 105 RGMAQ----RAHEQLKSLGRNLNVnATCLGfDTTAEN-DKI---SHVLMGTPkDFL--SNIPSDT------SRIKMFVLD 168
Cdd:COG1205 111 KALARdqlrRLRELAEALGLGVRV-ATYDG-DTPPEErRWIrehPDIVLTNP-DMLhyGLLPHHTrwarffRNLRYVVID 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 169 EAdemlskgfkdQIYE-VF---------------RSMPQDVQVVLLSATM--PSEV------LDVTnrfmrdpiriLVKK 224
Cdd:COG1205 188 EA----------HTYRgVFgshvanvlrrlrricRHYGSDPQFILASATIgnPAEHaerltgRPVT----------VVDE 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 225 D--------------ELTLEGIRQFYINvqkdEWKfNCLCDLLKtsRETQALIFCNTRRRV----TQLTEQLM--SIPIK 284
Cdd:COG1205 248 DgsprgertfvlwnpPLVDDGIRRSALA----EAA-RLLADLVR--EGLRTLVFTRSRRGAellaRYARRALRepDLADR 320
|
330 340 350
....*....|....*....|....*....|.
gi 922580233 285 VSCFHGNMEHNEREDMVKDFNSRNTRVLVTT 315
Cdd:COG1205 321 VAAYRAGYLPEERREIERGLRSGELLGVVST 351
|
|
| Cas3_I |
cd09639 |
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short ... |
66-330 |
3.97e-05 |
|
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I
Pssm-ID: 187770 [Multi-domain] Cd Length: 353 Bit Score: 45.11 E-value: 3.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 66 DVTIQSQAGSGKTVISLIDILQGIDCEDAhLQVILLAPQRGMAQRAHEQLKSLGRNLNVNATCLGFDTTAE---NDKISH 142
Cdd:cd09639 1 LLVIEAPTGYGKTEAALLWALHSLKSQKA-DRVIIALPTRATINAMYRRAKEAFGETGLYHSSILSSRIKEmgdSEEFEH 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 143 VL----MGTPKDFLSNIPSDT------SRIKMF---------------VLDEADEMLS--KGFKDQIYEVFRSMpqDVQV 195
Cdd:cd09639 80 LFplyiHSNDTLFLDPITVCTidqvlkSVFGEFghyeftlasiansllIFDEVHFYDEytLALILAVLEVLKDN--DVPI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 196 VLLSATMPsEVLDvtnRFMRDpIRILVKKDELTLEGIRQFYINVQKDEW--KFNCLCDLLKTSRE-TQALIFCNTRRRVT 272
Cdd:cd09639 158 LLMSATLP-KFLK---EYAEK-IGYVEENEPLDLKPNERAPFIKIESDKvgEISSLERLLEFIKKgGSVAIIVNTVDRAQ 232
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 922580233 273 QLTEQLM-SIP-IKVSCFHGNMEHNERED---MVKDFNSRN-TRVLVTTDLMARGMNIRKSLII 330
Cdd:cd09639 233 EFYQQLKeKGPeEEIMLIHSRFTEKDRAKkeaELLLEFKKSeKFVIVATQVIEASLDISVDVMI 296
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
50-202 |
1.35e-04 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 43.00 E-value: 1.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 50 PSAIQKSAVAPCTTGKDVTIQSQAGSGKTVISLIDILQGI-DCEDAHLQVILLAPQRGMAQRAHEQLKSL--GRNLNVNA 126
Cdd:cd17956 22 PWLLPSSKSTPPYRPGDLCVSAPTGSGKTLAYVLPIVQALsKRVVPRLRALIVVPTKELVQQVYKVFESLckGTGLKVVS 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 127 TC-----------LGFDTTAENDKISHVLMGTPKDFL----SNIPSDTSRIKMFVLDEADEMLSKGFKD----QIYEVFR 187
Cdd:cd17956 102 LSgqksfkkeqklLLVDTSGRYLSRVDILVATPGRLVdhlnSTPGFTLKHLRFLVIDEADRLLNQSFQDwletVMKALGR 181
|
170 180 190
....*....|....*....|....*....|.
gi 922580233 188 SMPQD----------------VQVVLLSATM 202
Cdd:cd17956 182 PTAPDlgsfgdanllersvrpLQKLLFSATL 212
|
|
| DEXHc_archSki2 |
cd18028 |
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ... |
54-203 |
1.60e-04 |
|
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350786 [Multi-domain] Cd Length: 177 Bit Score: 41.94 E-value: 1.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 54 QKSAV-APCTTGKDVTIQSQAGSGKTVISLIDILQGIdceDAHLQVILLAPQRGMAQRAHEQLKSL-GRNLNVNATCLGF 131
Cdd:cd18028 6 QAEAVrAGLLKGENLLISIPTASGKTLIAEMAMVNTL---LEGGKALYLVPLRALASEKYEEFKKLeEIGLKVGISTGDY 82
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 922580233 132 DTTAENDKISHVLMGTPKDF---LSNIPSDTSRIKMFVLDEAdEMLSKGFKDQIYEV----FRSMPQDVQVVLLSATMP 203
Cdd:cd18028 83 DEDDEWLGDYDIIVATYEKFdslLRHSPSWLRDVGVVVVDEI-HLISDEERGPTLESivarLRRLNPNTQIIGLSATIG 160
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
245-333 |
3.70e-04 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 42.52 E-value: 3.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 245 KFNCLCDLLKTSRETQ--ALIFCNTRRRVTQLTEQLMSIPIKVSCFHGNMEHNEREDMVKDFNSRN--TRVLVTTDLMAR 320
Cdd:COG0553 534 KLEALLELLEELLAEGekVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPeaPVFLISLKAGGE 613
|
90
....*....|....
gi 922580233 321 GMNI-RKSLIINYD 333
Cdd:COG0553 614 GLNLtAADHVIHYD 627
|
|
| COG1202 |
COG1202 |
Superfamily II helicase, archaea-specific [Replication, recombination and repair]; |
260-321 |
1.48e-03 |
|
Superfamily II helicase, archaea-specific [Replication, recombination and repair];
Pssm-ID: 440815 [Multi-domain] Cd Length: 790 Bit Score: 40.64 E-value: 1.48e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 922580233 260 QALIFCNTRRRVTQLTEQLmsiPIKVSCFHGNMEHNEREDMVKDFNSRNTRVLVTTDLMARG 321
Cdd:COG1202 429 QTIIFTNSRRRCHEIARAL---GYKAAPYHAGLDYGERKKVERRFADQELAAVVTTAALAAG 487
|
|
| PLN03137 |
PLN03137 |
ATP-dependent DNA helicase; Q4-like; Provisional |
248-365 |
1.60e-03 |
|
ATP-dependent DNA helicase; Q4-like; Provisional
Pssm-ID: 215597 [Multi-domain] Cd Length: 1195 Bit Score: 40.65 E-value: 1.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580233 248 CLCDLLKTSRETQ----ALIFCNTRRRVTQLTEQLMSIPIKVSCFHGNMEHNEREDMVKDFNSRNTRVLVTTdlMARGMN 323
Cdd:PLN03137 666 CLEDIDKFIKENHfdecGIIYCLSRMDCEKVAERLQEFGHKAAFYHGSMDPAQRAFVQKQWSKDEINIICAT--VAFGMG 743
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 922580233 324 IRK---SLIINYDVSGNMENYMLRNGRQGNFGSKGLPISFFTEND 365
Cdd:PLN03137 744 INKpdvRFVIHHSLPKSIEGYHQECGRAGRDGQRSSCVLYYSYSD 788
|
|
| SF2_C_Ski2 |
cd18795 |
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an ... |
256-323 |
5.06e-03 |
|
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. This family includes spliceosomal Brr2 RNA helicase, ASCC3 (involved in the repair of N-alkylated nucleotides), Mtr4 (involved in processing of structured RNAs), DDX60 (involved in viral RNA degradation), and other proteins. Ski2-like RNA helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350182 [Multi-domain] Cd Length: 154 Bit Score: 37.15 E-value: 5.06e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 922580233 256 SRETQALIFCNTRRRvTQLTEQLMSipiKVSCFHGNMEHNEREDMVKDFNSRNTRVLVTTDLMARGMN 323
Cdd:cd18795 41 SEGKPVLVFCSSRKE-CEKTAKDLA---GIAFHHAGLTREDRELVEELFREGLIKVLVATSTLAAGVN 104
|
|
| |
