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Conserved domains on  [gi|392894929|ref|NP_498101|]
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Protein HIRA [Caenorhabditis elegans]

Protein Classification

WD40 and HIRA_B domain-containing protein( domain architecture ID 13236943)

protein containing domains WD40, HIRA_B, and Hira

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
10-351 2.39e-39

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 151.22  E-value: 2.39e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929  10 TFVGHdTGSILAIDCHPSGKKFITCGqkartSNGLVVVWNAEPvldkkkasnenvPKLLFQVESQSQS-NSCRWSPDGKR 88
Cdd:COG2319  115 TLTGH-TGAVRSVAFSPDGKTLASGS-----ADGTVRLWDLAT------------GKLLRTLTGHSGAvTSVAFSPDGKL 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929  89 FAFGSDDSSVSVWeyvglinsmgsitggaqNVERYKECCVLRGHSMEVLTVEWSPNGKYLASGSIDYRIIIYNARKlPDR 168
Cdd:COG2319  177 LASGSDDGTVRLW-----------------DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT-GKL 238

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929 169 ITVLNDIQLPVKGLSWDPIGKYLASLEGDKKLRFWATDSWQCVKSVTEPFESnieetmLTRLDWSPDGKYLmtpaAVRSG 248
Cdd:COG2319  239 LRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG------VNSVAFSPDGKLL----ASGSD 308

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929 249 KPLIKLIQRQTWKSDQFLAGHHKGTTCVRAMPrlieanlkNGKRMqltcaAVGSRDKSISIWvFPGTLKPLFVINNifnH 328
Cdd:COG2319  309 DGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP--------DGKTL-----ASGSDDGTVRLW-DLATGELLRTLTG---H 371

                        330       340
                 ....*....|....*....|....*..
gi 392894929 329 T--VMDFAWC--GRNLLACSQDGTVKV 351
Cdd:COG2319  372 TgaVTSVAFSpdGRTLASGSADGTVRL 398
Hira super family cl15655
TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are ...
 695-885 1.61e-23

TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are implicated in the assembly of repressive chromatin. These proteins also contain pfam00400.


The actual alignment was detected with superfamily member pfam07569:

Pssm-ID: 462211  Cd Length: 221  Bit Score: 100.00  E-value: 1.61e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929  695 LRLDSLPVLIGVTEHAAYALTENGRLSTWNLKLGKAVVTR---QPLFD-----CVEASTDNSLISADVSETGVPLIVFSN 766
Cdd:pfam07569   8 IVLGSPASFLECSGSYLLAVTSVGLLYVWDIKKQKALLPPvslAPLLDsssrySDKLTRAPTITSASLTSNGVPIVTLSN 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929  767 GSIFTFNVSLSCWI-----------------QAITTNVLGRLTSPISDAQlSCSNGTTNSAGPlVRLLKRMRKQATAPGV 829
Cdd:pfam07569  88 GDGYLYDKSLETWLrisdswwalgsqywdstGSSRSSSQSSAAGILSFLE-RKTNEELLRKGR-GRLLQRLAKTLLMKEG 165

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 392894929  830 APQVVKAVKESQLEQLLHCAEQLGNPQDYQTMLMLYVETLCEGGSEKKLKNILNDL 885
Cdd:pfam07569 166 FENFETVVTLAHLENRLAAALLLGSPDEYRHWLLMYAKRLAEEGLKGRLRELCKEL 221
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
10-351 2.39e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 151.22  E-value: 2.39e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929  10 TFVGHdTGSILAIDCHPSGKKFITCGqkartSNGLVVVWNAEPvldkkkasnenvPKLLFQVESQSQS-NSCRWSPDGKR 88
Cdd:COG2319  115 TLTGH-TGAVRSVAFSPDGKTLASGS-----ADGTVRLWDLAT------------GKLLRTLTGHSGAvTSVAFSPDGKL 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929  89 FAFGSDDSSVSVWeyvglinsmgsitggaqNVERYKECCVLRGHSMEVLTVEWSPNGKYLASGSIDYRIIIYNARKlPDR 168
Cdd:COG2319  177 LASGSDDGTVRLW-----------------DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT-GKL 238

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929 169 ITVLNDIQLPVKGLSWDPIGKYLASLEGDKKLRFWATDSWQCVKSVTEPFESnieetmLTRLDWSPDGKYLmtpaAVRSG 248
Cdd:COG2319  239 LRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG------VNSVAFSPDGKLL----ASGSD 308

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929 249 KPLIKLIQRQTWKSDQFLAGHHKGTTCVRAMPrlieanlkNGKRMqltcaAVGSRDKSISIWvFPGTLKPLFVINNifnH 328
Cdd:COG2319  309 DGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP--------DGKTL-----ASGSDDGTVRLW-DLATGELLRTLTG---H 371

                        330       340
                 ....*....|....*....|....*..
gi 392894929 329 T--VMDFAWC--GRNLLACSQDGTVKV 351
Cdd:COG2319  372 TgaVTSVAFSpdGRTLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-351 2.39e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 124.75  E-value: 2.39e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929  10 TFVGHdTGSILAIDCHPSGKKFITCGqkartSNGLVVVWNAEPvldkkkasnenvPKLLFQVESQSQS-NSCRWSPDGKR 88
Cdd:cd00200    4 TLKGH-TGGVTCVAFSPDGKLLATGS-----GDGTIKVWDLET------------GELLRTLKGHTGPvRDVAASADGTY 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929  89 FAFGSDDSSVSVWeyvglinsmgsitggaqNVERYKECCVLRGHSMEVLTVEWSPNGKYLASGSIDYRIIIYNARKlPDR 168
Cdd:cd00200   66 LASGSSDKTIRLW-----------------DLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVET-GKC 127

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929 169 ITVLNDIQLPVKGLSWDPIGKYLASLEGDKKLRFWATDSWQCVKSvtepFESNIEEtmLTRLDWSPDGKYLMTPAAVRSg 248
Cdd:cd00200  128 LTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVAT----LTGHTGE--VNSVAFSPDGEKLLSSSSDGT- 200

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929 249 kplIKLIQRQTWKSDQFLAGHHKGTTCVRAMP-RLIeanlkngkrmqltcAAVGSRDKSISIWVFpGTLKPLFVINNiFN 327
Cdd:cd00200  201 ---IKLWDLSTGKCLGTLRGHENGVNSVAFSPdGYL--------------LASGSEDGTIRVWDL-RTGECVQTLSG-HT 261

                        330       340
                 ....*....|....*....|....*.
gi 392894929 328 HTVMDFAWC--GRNLLACSQDGTVKV 351
Cdd:cd00200  262 NSVTSLAWSpdGKRLASGSADGTIRI 287
Hira pfam07569
TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are ...
 695-885 1.61e-23

TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are implicated in the assembly of repressive chromatin. These proteins also contain pfam00400.


Pssm-ID: 462211  Cd Length: 221  Bit Score: 100.00  E-value: 1.61e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929  695 LRLDSLPVLIGVTEHAAYALTENGRLSTWNLKLGKAVVTR---QPLFD-----CVEASTDNSLISADVSETGVPLIVFSN 766
Cdd:pfam07569   8 IVLGSPASFLECSGSYLLAVTSVGLLYVWDIKKQKALLPPvslAPLLDsssrySDKLTRAPTITSASLTSNGVPIVTLSN 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929  767 GSIFTFNVSLSCWI-----------------QAITTNVLGRLTSPISDAQlSCSNGTTNSAGPlVRLLKRMRKQATAPGV 829
Cdd:pfam07569  88 GDGYLYDKSLETWLrisdswwalgsqywdstGSSRSSSQSSAAGILSFLE-RKTNEELLRKGR-GRLLQRLAKTLLMKEG 165

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 392894929  830 APQVVKAVKESQLEQLLHCAEQLGNPQDYQTMLMLYVETLCEGGSEKKLKNILNDL 885
Cdd:pfam07569 166 FENFETVVTLAHLENRLAAALLLGSPDEYRHWLLMYAKRLAEEGLKGRLRELCKEL 221
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 124-161 3.66e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 3.66e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 392894929   124 KECCVLRGHSMEVLTVEWSPNGKYLASGSIDYRIIIYN 161
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 139-241 1.94e-06

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 49.19  E-value: 1.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929  139 VEWSPNGK--YLASGSIDYRIIIYNARKLPdritVLNDIQLPVKGLSWDPIGKYLA-----SLEGDkkLRFWATDSWQCV 211
Cdd:pfam08662  65 VAWSPNGKefAVIYGYMPAKVSFFDLKGNV----IHSFGEQPRNTIFWSPFGRLVLlagfgNLAGD--IEFWDVVNKKKI 138

                          90       100       110
                  ....*....|....*....|....*....|
gi 392894929  212 ksvtepfeSNIEETMLTRLDWSPDGKYLMT 241
Cdd:pfam08662 139 --------ATAEASNATLCEWSPDGRYFLT 160
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
10-351 2.39e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 151.22  E-value: 2.39e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929  10 TFVGHdTGSILAIDCHPSGKKFITCGqkartSNGLVVVWNAEPvldkkkasnenvPKLLFQVESQSQS-NSCRWSPDGKR 88
Cdd:COG2319  115 TLTGH-TGAVRSVAFSPDGKTLASGS-----ADGTVRLWDLAT------------GKLLRTLTGHSGAvTSVAFSPDGKL 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929  89 FAFGSDDSSVSVWeyvglinsmgsitggaqNVERYKECCVLRGHSMEVLTVEWSPNGKYLASGSIDYRIIIYNARKlPDR 168
Cdd:COG2319  177 LASGSDDGTVRLW-----------------DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT-GKL 238

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929 169 ITVLNDIQLPVKGLSWDPIGKYLASLEGDKKLRFWATDSWQCVKSVTEPFESnieetmLTRLDWSPDGKYLmtpaAVRSG 248
Cdd:COG2319  239 LRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG------VNSVAFSPDGKLL----ASGSD 308

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929 249 KPLIKLIQRQTWKSDQFLAGHHKGTTCVRAMPrlieanlkNGKRMqltcaAVGSRDKSISIWvFPGTLKPLFVINNifnH 328
Cdd:COG2319  309 DGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP--------DGKTL-----ASGSDDGTVRLW-DLATGELLRTLTG---H 371

                        330       340
                 ....*....|....*....|....*..
gi 392894929 329 T--VMDFAWC--GRNLLACSQDGTVKV 351
Cdd:COG2319  372 TgaVTSVAFSpdGRTLASGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
78-355 1.63e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 142.74  E-value: 1.63e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929  78 NSCRWSPDGKRFAFGSDDSSVSVWeyvglinsmgsitggaqNVERYKECCVLRGHSMEVLTVEWSPNGKYLASGSIDYRI 157
Cdd:COG2319  124 RSVAFSPDGKTLASGSADGTVRLW-----------------DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTV 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929 158 IIYNARKlPDRITVLNDIQLPVKGLSWDPIGKYLASLEGDKKLRFWATDSWQCVKSVTEPfesnieETMLTRLDWSPDGK 237
Cdd:COG2319  187 RLWDLAT-GKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGH------SGSVRSVAFSPDGR 259

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929 238 YLmtpaAVRSGKPLIKLIQRQTWKSDQFLAGHHKGTTCVRAMPrlieanlkNGKRMqltcaAVGSRDKSISIWvFPGTLK 317
Cdd:COG2319  260 LL----ASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP--------DGKLL-----ASGSDDGTVRLW-DLATGK 321

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 392894929 318 PLFVINNiFNHTVMDFAWC--GRNLLACSQDGTVKVIHLS 355
Cdd:COG2319  322 LLRTLTG-HTGAVRSVAFSpdGKTLASGSDDGTVRLWDLA 360
WD40 COG2319
WD40 repeat [General function prediction only];
10-310 1.62e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 140.05  E-value: 1.62e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929  10 TFVGHdTGSILAIDCHPSGKKFITCGqkartSNGLVVVWNAEPvldkkkasnenvPKLLFQVESQSQS-NSCRWSPDGKR 88
Cdd:COG2319  157 TLTGH-SGAVTSVAFSPDGKLLASGS-----DDGTVRLWDLAT------------GKLLRTLTGHTGAvRSVAFSPDGKL 218

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929  89 FAFGSDDSSVSVWeyvglinsmgsitggaqNVERYKECCVLRGHSMEVLTVEWSPNGKYLASGSIDYRIIIYNARKlPDR 168
Cdd:COG2319  219 LASGSADGTVRLW-----------------DLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT-GEL 280

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929 169 ITVLNDIQLPVKGLSWDPIGKYLASLEGDKKLRFWATDSWQCVKSVTEPfesnieETMLTRLDWSPDGKYLmtpaAVRSG 248
Cdd:COG2319  281 LRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGH------TGAVRSVAFSPDGKTL----ASGSD 350

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 392894929 249 KPLIKLIQRQTWKSDQFLAGHHKGTTCVRAMPrlieanlkNGKRmqltcAAVGSRDKSISIW 310
Cdd:COG2319  351 DGTVRLWDLATGELLRTLTGHTGAVTSVAFSP--------DGRT-----LASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-351 2.39e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 124.75  E-value: 2.39e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929  10 TFVGHdTGSILAIDCHPSGKKFITCGqkartSNGLVVVWNAEPvldkkkasnenvPKLLFQVESQSQS-NSCRWSPDGKR 88
Cdd:cd00200    4 TLKGH-TGGVTCVAFSPDGKLLATGS-----GDGTIKVWDLET------------GELLRTLKGHTGPvRDVAASADGTY 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929  89 FAFGSDDSSVSVWeyvglinsmgsitggaqNVERYKECCVLRGHSMEVLTVEWSPNGKYLASGSIDYRIIIYNARKlPDR 168
Cdd:cd00200   66 LASGSSDKTIRLW-----------------DLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVET-GKC 127

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929 169 ITVLNDIQLPVKGLSWDPIGKYLASLEGDKKLRFWATDSWQCVKSvtepFESNIEEtmLTRLDWSPDGKYLMTPAAVRSg 248
Cdd:cd00200  128 LTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVAT----LTGHTGE--VNSVAFSPDGEKLLSSSSDGT- 200

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929 249 kplIKLIQRQTWKSDQFLAGHHKGTTCVRAMP-RLIeanlkngkrmqltcAAVGSRDKSISIWVFpGTLKPLFVINNiFN 327
Cdd:cd00200  201 ---IKLWDLSTGKCLGTLRGHENGVNSVAFSPdGYL--------------LASGSEDGTIRVWDL-RTGECVQTLSG-HT 261

                        330       340
                 ....*....|....*....|....*.
gi 392894929 328 HTVMDFAWC--GRNLLACSQDGTVKV 351
Cdd:cd00200  262 NSVTSLAWSpdGKRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
75-351 1.44e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 122.33  E-value: 1.44e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929  75 SQSNSCRWSPDGKRFAFGSDDSSVSVWeyvglinsmgsitggaqNVERYKECCVLRGHSMEVLTVEWSPNGKYLASGSID 154
Cdd:COG2319   79 AAVLSVAFSPDGRLLASASADGTVRLW-----------------DLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSAD 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929 155 YRIIIYNARKlPDRITVLNDIQLPVKGLSWDPIGKYLASLEGDKKLRFWATDSWQCVKSVTEPfesnieETMLTRLDWSP 234
Cdd:COG2319  142 GTVRLWDLAT-GKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGH------TGAVRSVAFSP 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929 235 DGKYLmtpaAVRSGKPLIKLIQRQTWKSDQFLAGHHKGTTCVRAMPrlieanlkNGKRmqltcAAVGSRDKSISIWVfPG 314
Cdd:COG2319  215 DGKLL----ASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP--------DGRL-----LASGSADGTVRLWD-LA 276

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 392894929 315 TLKPLFVINNiFNHTVMDFAWC--GRNLLACSQDGTVKV 351
Cdd:COG2319  277 TGELLRTLTG-HSGGVNSVAFSpdGKLLASGSDDGTVRL 314
WD40 COG2319
WD40 repeat [General function prediction only];
10-207 1.61e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.22  E-value: 1.61e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929  10 TFVGHdTGSILAIDCHPSGKKFITCGqkartSNGLVVVWNAEPvldkkkasnenvPKLLFQVESQSQS-NSCRWSPDGKR 88
Cdd:COG2319  241 TLTGH-SGSVRSVAFSPDGRLLASGS-----ADGTVRLWDLAT------------GELLRTLTGHSGGvNSVAFSPDGKL 302

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929  89 FAFGSDDSSVSVWeyvglinsmgsitggaqNVERYKECCVLRGHSMEVLTVEWSPNGKYLASGSIDYRIIIYNARKLPdR 168
Cdd:COG2319  303 LASGSDDGTVRLW-----------------DLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE-L 364

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 392894929 169 ITVLNDIQLPVKGLSWDPIGKYLASLEGDKKLRFWATDS 207
Cdd:COG2319  365 LRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
Hira pfam07569
TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are ...
 695-885 1.61e-23

TUP1-like enhancer of split; The Hira proteins are found in a range of eukaryotes and are implicated in the assembly of repressive chromatin. These proteins also contain pfam00400.


Pssm-ID: 462211  Cd Length: 221  Bit Score: 100.00  E-value: 1.61e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929  695 LRLDSLPVLIGVTEHAAYALTENGRLSTWNLKLGKAVVTR---QPLFD-----CVEASTDNSLISADVSETGVPLIVFSN 766
Cdd:pfam07569   8 IVLGSPASFLECSGSYLLAVTSVGLLYVWDIKKQKALLPPvslAPLLDsssrySDKLTRAPTITSASLTSNGVPIVTLSN 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929  767 GSIFTFNVSLSCWI-----------------QAITTNVLGRLTSPISDAQlSCSNGTTNSAGPlVRLLKRMRKQATAPGV 829
Cdd:pfam07569  88 GDGYLYDKSLETWLrisdswwalgsqywdstGSSRSSSQSSAAGILSFLE-RKTNEELLRKGR-GRLLQRLAKTLLMKEG 165

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 392894929  830 APQVVKAVKESQLEQLLHCAEQLGNPQDYQTMLMLYVETLCEGGSEKKLKNILNDL 885
Cdd:pfam07569 166 FENFETVVTLAHLENRLAAALLLGSPDEYRHWLLMYAKRLAEEGLKGRLRELCKEL 221
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-204 1.12e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.55  E-value: 1.12e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929  10 TFVGHdTGSILAIDCHPSGKkFITCGqkarTSNGLVVVWNAepvldkkkasNENVPKLLFQvESQSQSNSCRWSPDGKRF 89
Cdd:cd00200  130 TLRGH-TDWVNSVAFSPDGT-FVASS----SQDGTIKLWDL----------RTGKCVATLT-GHTGEVNSVAFSPDGEKL 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929  90 AFGSDDSSVSVWEYvglinSMGsitggaqnveryKECCVLRGHSMEVLTVEWSPNGKYLASGSIDYRIIIYNARKlPDRI 169
Cdd:cd00200  193 LSSSSDGTIKLWDL-----STG------------KCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRT-GECV 254

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 392894929 170 TVLNDIQLPVKGLSWDPIGKYLASLEGDKKLRFWA 204
Cdd:cd00200  255 QTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
128-355 3.18e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.13  E-value: 3.18e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929 128 VLRGHSMEVLTVEWSPNGKYLASGSIDYRIIIYNARKlPDRITVLNDIQLPVKGLSWDPIGKYLASLEGDKKLRFWATDS 207
Cdd:COG2319   73 TLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT-GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929 208 WQCVKSVTEPfesnieETMLTRLDWSPDGKYLmtpaAVRSGKPLIKLIQRQTWKSDQFLAGHHKGTTCVRAMPrlieanl 287
Cdd:COG2319  152 GKLLRTLTGH------SGAVTSVAFSPDGKLL----ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP------- 214

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929 288 kNGKRMqltcaAVGSRDKSISIWvFPGTLKPLFVINNiFNHTVMDFAWC--GRNLLACSQDGTVKVIHLS 355
Cdd:COG2319  215 -DGKLL-----ASGSADGTVRLW-DLATGKLLRTLTG-HSGSVRSVAFSpdGRLLASGSADGTVRLWDLA 276
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 125-351 3.55e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.07  E-value: 3.55e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929 125 ECCVLRGHSMEVLTVEWSPNGKYLASGSIDYRIIIYNArKLPDRITVLNDIQLPVKGLSWDPIGKYLASLEGDKKLRFWA 204
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDL-ETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929 205 TDSWQCVKSVTEpFESNIeetmlTRLDWSPDGKYLMTpaAVRSGKplIKLIQRQTWKSDQFLAGHHKGTTCVRAMPrlie 284
Cdd:cd00200   80 LETGECVRTLTG-HTSYV-----SSVAFSPDGRILSS--SSRDKT--IKVWDVETGKCLTTLRGHTDWVNSVAFSP---- 145

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392894929 285 anlknGKRMqltcAAVGSRDKSISIWvFPGTLKPlfvINNIFNHT--VMDFAWC--GRNLLACSQDGTVKV 351
Cdd:cd00200  146 -----DGTF----VASSSQDGTIKLW-DLRTGKC---VATLTGHTgeVNSVAFSpdGEKLLSSSSDGTIKL 203
WD40 COG2319
WD40 repeat [General function prediction only];
128-355 7.53e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.56  E-value: 7.53e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929 128 VLRGHSMEVLTVEWSPNGKYLASGSIDYRIIIYNARKLPDRITvLNDIQLPVKGLSWDPIGKYLASLEGDKKLRFWATDS 207
Cdd:COG2319   31 LLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLAT-LLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929 208 WQCVKSVTEPFESnieetmLTRLDWSPDGKYLmtpaAVRSGKPLIKLIQRQTWKSDQFLAGHHKGTTCVRAMPrlieanl 287
Cdd:COG2319  110 GLLLRTLTGHTGA------VRSVAFSPDGKTL----ASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSP------- 172

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 392894929 288 kNGKRMqltcaAVGSRDKSISIWVfPGTLKPLFVINnifNHT--VMDFAWC--GRNLLACSQDGTVKVIHLS 355
Cdd:COG2319  173 -DGKLL-----ASGSDDGTVRLWD-LATGKLLRTLT---GHTgaVRSVAFSpdGKLLASGSADGTVRLWDLA 234
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 124-161 3.66e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 3.66e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 392894929   124 KECCVLRGHSMEVLTVEWSPNGKYLASGSIDYRIIIYN 161
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 81-239 6.46e-07

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 53.50  E-value: 6.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929   81 RWSPDGKRFAFGSDDS-SVSVWEYvglinsmgSITGGAQnVERykeccVLRGHSMEVLTVEWSPNGKYLASGSIDYRIII 159
Cdd:COG4946   349 AWSPDGKSIAYFSDASgEYELYIA--------PADGSGE-PKQ-----LTLGDLGRVFNPVWSPDGKKIAFTDNRGRLWV 414

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929  160 YN-----ARKLpDRitvlNDIQLPVKGLSWDPIGKYLA---------------SLEGDKKlrFWATDSWqcvKSVTEPFe 219
Cdd:COG4946   415 VDlasgkVRKV-DT----DGYGDGISDLAWSPDSKWLAyskpgpnqlsqiflyDVETGKT--VQLTDGR---YDDGSPA- 483

                         170       180
                  ....*....|....*....|
gi 392894929  220 snieetmltrldWSPDGKYL 239
Cdd:COG4946   484 ------------FSPDGKYL 491
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 83-239 1.79e-06

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 51.96  E-value: 1.79e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929   83 SPDGKRFAF---GsdDS-SVSVWEyvglinsmGSI-----TGGAQnvERYkeccvlrghsmevltVEWSPNGKYLA---- 149
Cdd:COG4946   310 SPDGKRVAFearG--EVfTVPAEK--------GPTrnltnTPGVR--ERL---------------PAWSPDGKSIAyfsd 362

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929  150 -SGSidYRIIIYNARKL--PDRITvLNDIQLPVkGLSWDPIGKYLASLEGDKKLRFWATDSWQCVKSVTEPFESNIEEtm 226
Cdd:COG4946   363 aSGE--YELYIAPADGSgePKQLT-LGDLGRVF-NPVWSPDGKKIAFTDNRGRLWVVDLASGKVRKVDTDGYGDGISD-- 436

                         170
                  ....*....|...
gi 392894929  227 ltrLDWSPDGKYL 239
Cdd:COG4946   437 ---LAWSPDSKWL 446
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 139-241 1.94e-06

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 49.19  E-value: 1.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929  139 VEWSPNGK--YLASGSIDYRIIIYNARKLPdritVLNDIQLPVKGLSWDPIGKYLA-----SLEGDkkLRFWATDSWQCV 211
Cdd:pfam08662  65 VAWSPNGKefAVIYGYMPAKVSFFDLKGNV----IHSFGEQPRNTIFWSPFGRLVLlagfgNLAGD--IEFWDVVNKKKI 138

                          90       100       110
                  ....*....|....*....|....*....|
gi 392894929  212 ksvtepfeSNIEETMLTRLDWSPDGKYLMT 241
Cdd:pfam08662 139 --------ATAEASNATLCEWSPDGRYFLT 160
WD40 pfam00400
WD domain, G-beta repeat;
128-161 6.64e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 6.64e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 392894929  128 VLRGHSMEVLTVEWSPNGKYLASGSIDYRIIIYN 161
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 78-102 6.77e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 6.77e-04
                           10        20
                   ....*....|....*....|....*
gi 392894929    78 NSCRWSPDGKRFAFGSDDSSVSVWE 102
Cdd:smart00320  16 TSVAFSPDGKYLASGSDDGTIKLWD 40
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 81-192 1.67e-03

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 40.04  E-value: 1.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894929  81 RWSPDGKRFAFGSDDS-SVSVWEYvglinsmgSITGGaqNVERykeccVLRGHSMEVLTVeWSPNGKYLASGSID---YR 156
Cdd:COG0823   37 AWSPDGRRIAFTSDRGgGPQIYVV--------DADGG--EPRR-----LTFGGGYNASPS-WSPDGKRLAFVSRSdgrFD 100

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 392894929 157 IIIYNARKlpDRITVLNDIQLpvkGLSWDPIGKYLA 192
Cdd:COG0823  101 IYVLDLDG--GAPRRLTDGPG---SPSWSPDGRRIV 131
WD40 pfam00400
WD domain, G-beta repeat;
78-102 5.07e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 5.07e-03
                          10        20
                  ....*....|....*....|....*
gi 392894929   78 NSCRWSPDGKRFAFGSDDSSVSVWE 102
Cdd:pfam00400  15 TSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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