BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554532   154 LKVEDRLIRVNKRYLSMMSPFFKALFYGELGEDK--EIYEMKEKFREIITFLRCIYPHRQpVTKKSLDYLLQLADRYQCQ 231
Cdd:pfam00651  15 LVVGDKEFRAHKAVLAACSPYFKALFSGQESESSvsEITLDDVSPEDFEALLEFMYTGKL-ISEENVDDLLAAADKLQIP 93

                          90
                  ....*....|...
gi 17554532   232 PIVDACEMFMCAH 244
Cdd:pfam00651  94 SLVDKCEEFLIKS 106

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554532   154 LKVEDRLIRVNKRYLSMMSPFFKALFYGELGEDK--EIYEMKEKFREIITFLRCIYPHRQpVTKKSLDYLLQLADRYQCQ 231
Cdd:pfam00651  15 LVVGDKEFRAHKAVLAACSPYFKALFSGQESESSvsEITLDDVSPEDFEALLEFMYTGKL-ISEENVDDLLAAADKLQIP 93

                          90
                  ....*....|...
gi 17554532   232 PIVDACEMFMCAH 244
Cdd:pfam00651  94 SLVDKCEEFLIKS 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554532 151 NALLKVEDRLIRVNKRYLSMMSPFFKALFYGELGEDKE-IYEMKEKFREII-TFLRCIYPHRQPVTKKSLDYLLQLADRY 228
Cdd:cd18253  20 DVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESREmLVEINGILAEAMdCFLQYVYTGKVKITTENVQYLFETSSLF 99

                        90
                ....*....|...
gi 17554532 229 QCQPIVDACEMFM 241
Cdd:cd18253 100 QISPLRDACAKFL 112

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554532   154 LKVEDRLIRVNKRYLSMMSPFFKALFYGELGEDK--EIYEMKEKFREIITFLRCIYPHRQpVTKKSLDYLLQLADRYQCQ 231
Cdd:pfam00651  15 LVVGDKEFRAHKAVLAACSPYFKALFSGQESESSvsEITLDDVSPEDFEALLEFMYTGKL-ISEENVDDLLAAADKLQIP 93

                          90
                  ....*....|...
gi 17554532   232 PIVDACEMFMCAH 244
Cdd:pfam00651  94 SLVDKCEEFLIKS 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554532 151 NALLKVEDRLIRVNKRYLSMMSPFFKALFYGELGEDKE-IYEMKEKFREII-TFLRCIYPHRQPVTKKSLDYLLQLADRY 228
Cdd:cd18253  20 DVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESREmLVEINGILAEAMdCFLQYVYTGKVKITTENVQYLFETSSLF 99

                        90
                ....*....|...
gi 17554532 229 QCQPIVDACEMFM 241
Cdd:cd18253 100 QISPLRDACAKFL 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554532 154 LKVEDRLIRVNKRYLSMMSPFFKALFYGELGEDK----EIYEMK-EKFREIITFlrcIYPHRQPVTKKSLDYLLQLADRY 228
Cdd:cd18343  26 LFVGGQEFKAHKSILAARSPVFNAMFEHEMEESKknrvEINDVDpEVFKEMMRF---IYTGKAPNLDKMADNLLAAADKY 102

                        90
                ....*....|....
gi 17554532 229 QCQPIVDACEMFMC 242
Cdd:cd18343 103 ALERLKVMCEEALC 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554532 154 LKVEDRLIRVNKRYLSMMSPFFKALFYGELGEDK----EIYEMKEK-FREIITFlrcIYPHRQPVTKKSLDYLLQLADRY 228
Cdd:cd18186   6 LVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSsseiELDDVSPEaFEALLDY---IYTGELELSEENVEELLAAADKL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554532 141 DYFDVLPE--EENAL----LKVEDRLIRVNKRYLSMMSPFFKALFYGELGEDK----EIYEMKEKFREIItfLRCIYPHR 210
Cdd:cd18238   1 DSFKVLHQfyENGELcdvtLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKqdsiTIKDIDEEAVELL--VDFAYTGK 78

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 17554532 211 QPVTKKSLDYLLQLADRYQCQPIVDACEMFMCAHYH 246
Cdd:cd18238  79 LTLTVDNVQSLLYAASLLQVEEVAKACCEFMKDHLH 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554532 152 ALLKVEDRLIRVNKRYLSMMSPFFKALFYGELGE-DKEIYEMKEKFREIIT-FLRCIYPHRQPVTKKSLDYLLQLADRYQ 229
Cdd:cd18240  20 VVIRVNGVEFPAHRNILCACSPYFRALFTNGWNEtEKKVYKIPGVSPEMMElIIEYAYTRTVPITAENVEELLPAADQFN 99

                        90
                ....*....|....*..
gi 17554532 230 CQPIVDACEMFMCAHYH 246
Cdd:cd18240 100 IMGIVKACCDFLEDQLC 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554532 154 LKVEDRLIRVNKRYLSMMSPFFKALFYGELGEDK----EIYEMK-EKFREIITFlrcIYPHRQPVTKKSLDYLLQLADRY 228
Cdd:cd18279  23 LCVGGQEFQAHKAILAARSPVFSAMFEHEMEESKknrvEINDVDpEVFKEMMRF---IYTGKAPNLDKMADDLLAAADKY 99

                        90
                ....*....|....*.
gi 17554532 229 QCQPIVDACEMFMCAH 244
Cdd:cd18279 100 ALERLKVMCEDALCSN 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554532 142 YFDVLpeeenalLKVEDRLIRVNKRYLSMMSPFFKALFYGELGEDK----EIYEMKEKFREIItfLRCIYPHRQPVTKKS 217
Cdd:cd18250  21 FFDVT-------LCAGGREFPCHRTVLAAASSYFRAMFAGELRESRadrvVLHGVSAEILGLL--LDFSYTGRVTVTQDN 91

                        90       100
                ....*....|....*....|....
gi 17554532 218 LDYLLQLADRYQCQPIVDACEMFM 241
Cdd:cd18250  92 VEALLRAADLFQFPSVKEACCAYL 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554532 157 EDRLIRVNKRYLSMMSPFFKALFYGELGEDK-EIYEMKE----KFREIITFlrcIYPHRQPVTKKSLDYLLQLADRYQCQ 231
Cdd:cd18338  29 EDVEIAAHRVVLAACSPYFHAMFTGEMSESRaKRVRIKEvdgwTLKMLIDY---VYTAEIQVTEENVQVLLPAAGLLQLQ 105

                        90
                ....*....|....*
gi 17554532 232 PIVDACEMFMCAHYH 246
Cdd:cd18338 106 DVKKTCCEFLESQLH 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554532 157 EDRLIRVNKRYLSMMSPFFKALFYGELGEDK----EIYEMK-EKFREIITFlrcIYPHRQPVTKKSLDYLLQLADRYQCQ 231
Cdd:cd18339  29 EDVEIEAHRVVLAACSPYFCAMFTGDMSESKakkiEIKDVDgQTLSKLIDY---IYTAEIEVTEENVQVLLPAASLLQLM 105

                        90
                ....*....|....*
gi 17554532 232 PIVDACEMFMCAHYH 246
Cdd:cd18339 106 DVRQNCCDFLQSQLH 120

kelch-like protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554532  161 IRVNKRYLSMMSPFFKALFYGELGEDK-EIYEMKEKFREIITFlrcIYPHRQPVTKKSLDYLLQLADRYQCQPIVDACEM 239
Cdd:PHA03098  23 IKVHKIILSSSSEYFKKMFKNNFKENEiNLNIDYDSFNEVIKY---IYTGKINITSNNVKDILSIANYLIIDFLINLCIN 99

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 17554532  240 FM--------CAHYHEYQKKTE--KCFSYVEKYKMQRVLRII 271
Cdd:PHA03098 100 YIikiiddnnCIDIYRFSFFYGckKLYSAAYNYIRNNIELIY 141

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554532 154 LKVEDRLIRVNKRYLSMMSPFFKALFYGELGEDKE----IYEMKEKFRE-IITFlrcIYPHRQPVTKKSLDYLLQLADRY 228
Cdd:cd18249  28 LVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQtevtIRDIDERAMElLIDF---AYTSQITVEEGNVQTLLPAACLL 104

                        90
                ....*....|...
gi 17554532 229 QCQPIVDACEMFM 241
Cdd:cd18249 105 QLAEIQEVCCEFL 117