|
Name |
Accession |
Description |
Interval |
E-value |
| UDPGlcNAc_PPase |
cd04193 |
UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; UDP-N-acetylglucosamine ... |
89-409 |
2.47e-133 |
|
UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; UDP-N-acetylglucosamine (UDPGlcNAc) pyrophosphorylase (UAP) (also named GlcNAc1P uridyltransferase), catalyzes the reversible conversion of UTP and GlcNAc1 to PPi and UDPGlcNAc. UDP-N-acetylglucosamine (UDPGlcNAc), the activated form of GlcNAc, is a key precursor of N- and O-linked glycosylations. It is essential for the synthesis of chitin (a major component of the fungal cell wall) and of the glycosylphosphatidylinositol (GPI) linker which anchors a variety of cell surface proteins to the plasma membrane. In bacteria, UDPGlcNAc represents an essential precursor for both peptidoglycan and lipopolysaccharide biosynthesis. Human UAP has two isoforms, resulting from alternative splicing of a single gene and differing by the presence or absence of 17 amino acids. UDPGlcNAc pyrophosphorylase shares significant sequence and structure conservation with UDPglucose pyrophosphorylase.
Pssm-ID: 133036 Cd Length: 323 Bit Score: 388.12 E-value: 2.47e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 89 LWNKGMDAIGRGEVCAIVLAGGQATRLGSSQPKGTIPLGInaSFGDSLLGIQAAKIALLQALAGEReHQNPGKIHWAVMT 168
Cdd:cd04193 3 WEEAGLKAIAEGKVAVLLLAGGQGTRLGFDGPKGMFPVGL--PSKKSLFQLQAERILKLQELAGEA-SGKKVPIPWYIMT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 169 SPGTEEATREHVKKlaaHHGFDFD-EQITIFSQDEIAAYDEQGNFLLGTKGSVVAAPNGNGGLYSAISA--HLPRLRAKG 245
Cdd:cd04193 80 SEATHEETRKFFKE---NNYFGLDpEQVHFFQQGMLPCVDFDGKILLEEKGKIAMAPNGNGGLYKALQTagILEDMKKRG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 246 IKYFHVYCVDNILCKVADPHFIGFAISNEADVATKCVPKQ-KGELVGSVCLDRGLPRVVEYSELGAELAEQKTPDGKYLF 324
Cdd:cd04193 157 IKYIHVYSVDNILVKVADPVFIGFCISKGADVGAKVVRKRyPTEKVGVVVLVDGKPQVVEYSEISDELAEKRDADGELQY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 325 GAGSIANHFFTMDFMDRVCS-PSSRLPYHRAHKKISYVNEQGTIVKPEKPNGIKLEQFIFDVFELSKRFFIWEVARNEEF 403
Cdd:cd04193 237 NAGNIANHFFSLDFLEKAAEmEEPSLPYHIAKKKIPYVDLEGGLVKPDEPNGIKLELFIFDVFPFAKNFVCLEVDREEEF 316
|
....*.
gi 17552518 404 SPLKNA 409
Cdd:cd04193 317 SPLKNA 322
|
|
| QRI1 |
COG4284 |
UDP-N-acetylglucosamine pyrophosphorylase [Carbohydrate transport and metabolism]; |
17-409 |
7.83e-93 |
|
UDP-N-acetylglucosamine pyrophosphorylase [Carbohydrate transport and metabolism];
Pssm-ID: 443425 Cd Length: 402 Bit Score: 287.55 E-value: 7.83e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 17 GSEPLLNFYNELSDAEKSKLFHQISTLNLSEAHQwFIDSADQRAPSTA----EDLKPV-LDSQHfvQAELHQVILDGLWN 91
Cdd:COG4284 9 GQEHLLRFWDELSEAQQKMLEAQIEEIDIDVFQH-LYRQLVLAEGATGlipeSDIEPApVTDLP--LTDLDEVDRDRAEE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 92 KGMDAIGRGEVCAIVLAGGQATRLGSSQPKGTIPLGINAsfGDSLLGIQAAKIallqaLAGEREHQNPgkIHWAVMTSPG 171
Cdd:COG4284 86 AGEEALRAGKVAVILLAGGQGTRLGFDGPKGLLPVRPVK--GKSLFDLIAEQV-----LAARRRYGVP--LPLYIMTSFR 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 172 TEEATREHvkkLAAHHGFDFD-EQITIFSQD-EIAAYDEQGNFLLGTKGSVVAAPNGNGGLYSAI--SAHLPRLRAKGIK 247
Cdd:COG4284 157 THEDTLAF---LEEHDYFGLDgLPVHFFLQGmEPALDADLGPVLLPADPELELCPPGHGGIYTALlaSGLLDKLLERGIR 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 248 YFHVYCVDNILCKVADPHFIGFAISNEADVATKCVPKQKG-ELVGSVCLDRGLPRVVEYSELGAELAEQKtpDGKYLFGA 326
Cdd:COG4284 234 YLFVSNVDNPLGAVPDPAFAGWHAASGAPFTAKVVRRTPPdEKVGHLARVDGRLILREYSQLPDEEAEAF--TGELRHPY 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 327 GSIANHFFTMDFMDRVC-SPSSRLPYHRAHKKISYVNEQGtivKPEKPNGIKLEQFIFDVFELSKRFFIWEVARNEEFSP 405
Cdd:COG4284 312 GNINNHWFDLDFLKRLLdERGLGLPLHRAEKKVDPLDESG---KPTSPNVIKFETFMFDAIPLFDGAVAIEVDREERFAP 388
|
....
gi 17552518 406 LKNA 409
Cdd:COG4284 389 VKNT 392
|
|
| PTZ00339 |
PTZ00339 |
UDP-N-acetylglucosamine pyrophosphorylase; Provisional |
93-462 |
2.58e-76 |
|
UDP-N-acetylglucosamine pyrophosphorylase; Provisional
Pssm-ID: 240368 Cd Length: 482 Bit Score: 247.35 E-value: 2.58e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 93 GMDAIGRGEVCAIVLAGGQATRLGSSQPKGTIPLGINAsfGDSLLGIQAAKIALLQALAGEREHQNPG-KIHWAVMTSPG 171
Cdd:PTZ00339 98 GLEIIKKGEVAVLILAGGLGTRLGSDKPKGLLECTPVK--KKTLFQFHCEKVRRLEEMAVAVSGGGDDpTIYILVLTSSF 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 172 TEEATREHVKKlaaHHGFDFD-EQITIFSQDEIAAYDE-QGNFLLGTKGSVVAAPNGNGGLYSAISAH--LPRLRAKGIK 247
Cdd:PTZ00339 176 NHDQTRQFLEE---NNFFGLDkEQVIFFKQSSLPCYDEnTGRFIMSSQGSLCTAPGGNGDVFKALAKCseLMDIVRKGIK 252
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 248 YFHVYCVDNILCKVADPHFIGFAISNEA-DVATKCVPKQKGELVGSVCLDRGLPRVVEYSELGAELAEQKTP-DGKYLFG 325
Cdd:PTZ00339 253 YVQVISIDNILAKVLDPEFIGLASSFPAhDVLNKCVKREDDESVGVFCLKDYEWQVVEYTEINERILNNDELlTGELAFN 332
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 326 AGSIANHFFTMDFMDRVCSPS--SRLPYHRAHKKISYVNEQGTivkpeKPNGIKLEQFIFDVFELSKRFFIWEVARNEEF 403
Cdd:PTZ00339 333 YGNICSHIFSLDFLKKVAANRlyESTPYHAARKKIPYINGPTD-----KTMGIKLEAFIFDIFRYAKNVLILEVDREDEF 407
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17552518 404 SPLKNAQSVGTDCLSTCQRDLSNVNKLWLErvQAKVTATEKP------IYLKTIVSYNGENLQEL 462
Cdd:PTZ00339 408 APIKNADGAAADTILNAQKLLLSLHTRWLE--AALETVAGNPreglnlCEISPLVSYGGEGLFQY 470
|
|
| UDPGP |
pfam01704 |
UTP--glucose-1-phosphate uridylyltransferase; This family consists of UTP--glucose-1-phosphate ... |
107-411 |
1.82e-23 |
|
UTP--glucose-1-phosphate uridylyltransferase; This family consists of UTP--glucose-1-phosphate uridylyltransferases, EC:2.7.7.9. Also known as UDP-glucose pyrophosphorylase (UDPGP) and Glucose-1-phosphate uridylyltransferase. UTP--glucose-1-phosphate uridylyltransferase catalyzes the interconversion of MgUTP + glucose-1-phosphate and UDP-glucose + MgPPi. UDP-glucose is an important intermediate in mammalian carbohydrate interconversion involved in various metabolic roles depending on tissue type. In Dictyostelium (slime mold) mutants in this enzyme abort the development cycle. Also within the family is UDP-N-acetylglucosamine or AGX1 and two hypothetical proteins from Borrelia burgdorferi the lyme disease spirochaete Swiss:O51893 and Swiss:O51036.
Pssm-ID: 460300 Cd Length: 412 Bit Score: 102.21 E-value: 1.82e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 107 LAGGQATRLGSSQPKGTIPLGINASFgdslLGIQAAKIallqalagerEHQNPG---KIHWAVMTSPGTEEATREHVKKL 183
Cdd:pfam01704 59 LNGGLGTSMGCVGPKSLIEVRDGLTF----LDLIVQQI----------EHLNKKynvDVPLVLMNSFNTDEDTKKIIRKY 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 184 AAHHgfdfdEQITIFSQDEIAAYDEQGNFLLGTKGSVVA---APNGNGGLYSAI--SAHLPRLRAKGIKYFHVYCVDNiL 258
Cdd:pfam01704 125 KGHK-----VDILTFNQSRYPRIDKDTLLPVPKSADSDEeewYPPGHGDLYESLynSGLLDKLLAEGKEYLFVSNIDN-L 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 259 CKVADPHFIGFAISNEADVATKCVPKQKG-ELVGSVCLDRGLPRVVEYSELGAELAEQKTPDGKY-LFGAGSIanhFFTM 336
Cdd:pfam01704 199 GATVDLNILNYMVDNGAEFLMEVTDKTRAdVKGGTLIEYDGKLRLLEIAQVPKEHVDEFKSIKKFkIFNTNNI---WINL 275
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17552518 337 DFMDRVCSpSSRLPYHRA-HKKisYVNEQGTIVKPEKPNGIKLEQFifdvfelsKRFFIWEVARnEEFSPLKNAQS 411
Cdd:pfam01704 276 KALKRVVE-EGELQLEIIvNKK--TLDNGENVIQLETAVGAAIKNF--------KNAIGINVPR-SRFLPVKTTSD 339
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| UDPGlcNAc_PPase |
cd04193 |
UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; UDP-N-acetylglucosamine ... |
89-409 |
2.47e-133 |
|
UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; UDP-N-acetylglucosamine (UDPGlcNAc) pyrophosphorylase (UAP) (also named GlcNAc1P uridyltransferase), catalyzes the reversible conversion of UTP and GlcNAc1 to PPi and UDPGlcNAc. UDP-N-acetylglucosamine (UDPGlcNAc), the activated form of GlcNAc, is a key precursor of N- and O-linked glycosylations. It is essential for the synthesis of chitin (a major component of the fungal cell wall) and of the glycosylphosphatidylinositol (GPI) linker which anchors a variety of cell surface proteins to the plasma membrane. In bacteria, UDPGlcNAc represents an essential precursor for both peptidoglycan and lipopolysaccharide biosynthesis. Human UAP has two isoforms, resulting from alternative splicing of a single gene and differing by the presence or absence of 17 amino acids. UDPGlcNAc pyrophosphorylase shares significant sequence and structure conservation with UDPglucose pyrophosphorylase.
Pssm-ID: 133036 Cd Length: 323 Bit Score: 388.12 E-value: 2.47e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 89 LWNKGMDAIGRGEVCAIVLAGGQATRLGSSQPKGTIPLGInaSFGDSLLGIQAAKIALLQALAGEReHQNPGKIHWAVMT 168
Cdd:cd04193 3 WEEAGLKAIAEGKVAVLLLAGGQGTRLGFDGPKGMFPVGL--PSKKSLFQLQAERILKLQELAGEA-SGKKVPIPWYIMT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 169 SPGTEEATREHVKKlaaHHGFDFD-EQITIFSQDEIAAYDEQGNFLLGTKGSVVAAPNGNGGLYSAISA--HLPRLRAKG 245
Cdd:cd04193 80 SEATHEETRKFFKE---NNYFGLDpEQVHFFQQGMLPCVDFDGKILLEEKGKIAMAPNGNGGLYKALQTagILEDMKKRG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 246 IKYFHVYCVDNILCKVADPHFIGFAISNEADVATKCVPKQ-KGELVGSVCLDRGLPRVVEYSELGAELAEQKTPDGKYLF 324
Cdd:cd04193 157 IKYIHVYSVDNILVKVADPVFIGFCISKGADVGAKVVRKRyPTEKVGVVVLVDGKPQVVEYSEISDELAEKRDADGELQY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 325 GAGSIANHFFTMDFMDRVCS-PSSRLPYHRAHKKISYVNEQGTIVKPEKPNGIKLEQFIFDVFELSKRFFIWEVARNEEF 403
Cdd:cd04193 237 NAGNIANHFFSLDFLEKAAEmEEPSLPYHIAKKKIPYVDLEGGLVKPDEPNGIKLELFIFDVFPFAKNFVCLEVDREEEF 316
|
....*.
gi 17552518 404 SPLKNA 409
Cdd:cd04193 317 SPLKNA 322
|
|
| QRI1 |
COG4284 |
UDP-N-acetylglucosamine pyrophosphorylase [Carbohydrate transport and metabolism]; |
17-409 |
7.83e-93 |
|
UDP-N-acetylglucosamine pyrophosphorylase [Carbohydrate transport and metabolism];
Pssm-ID: 443425 Cd Length: 402 Bit Score: 287.55 E-value: 7.83e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 17 GSEPLLNFYNELSDAEKSKLFHQISTLNLSEAHQwFIDSADQRAPSTA----EDLKPV-LDSQHfvQAELHQVILDGLWN 91
Cdd:COG4284 9 GQEHLLRFWDELSEAQQKMLEAQIEEIDIDVFQH-LYRQLVLAEGATGlipeSDIEPApVTDLP--LTDLDEVDRDRAEE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 92 KGMDAIGRGEVCAIVLAGGQATRLGSSQPKGTIPLGINAsfGDSLLGIQAAKIallqaLAGEREHQNPgkIHWAVMTSPG 171
Cdd:COG4284 86 AGEEALRAGKVAVILLAGGQGTRLGFDGPKGLLPVRPVK--GKSLFDLIAEQV-----LAARRRYGVP--LPLYIMTSFR 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 172 TEEATREHvkkLAAHHGFDFD-EQITIFSQD-EIAAYDEQGNFLLGTKGSVVAAPNGNGGLYSAI--SAHLPRLRAKGIK 247
Cdd:COG4284 157 THEDTLAF---LEEHDYFGLDgLPVHFFLQGmEPALDADLGPVLLPADPELELCPPGHGGIYTALlaSGLLDKLLERGIR 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 248 YFHVYCVDNILCKVADPHFIGFAISNEADVATKCVPKQKG-ELVGSVCLDRGLPRVVEYSELGAELAEQKtpDGKYLFGA 326
Cdd:COG4284 234 YLFVSNVDNPLGAVPDPAFAGWHAASGAPFTAKVVRRTPPdEKVGHLARVDGRLILREYSQLPDEEAEAF--TGELRHPY 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 327 GSIANHFFTMDFMDRVC-SPSSRLPYHRAHKKISYVNEQGtivKPEKPNGIKLEQFIFDVFELSKRFFIWEVARNEEFSP 405
Cdd:COG4284 312 GNINNHWFDLDFLKRLLdERGLGLPLHRAEKKVDPLDESG---KPTSPNVIKFETFMFDAIPLFDGAVAIEVDREERFAP 388
|
....
gi 17552518 406 LKNA 409
Cdd:COG4284 389 VKNT 392
|
|
| PTZ00339 |
PTZ00339 |
UDP-N-acetylglucosamine pyrophosphorylase; Provisional |
93-462 |
2.58e-76 |
|
UDP-N-acetylglucosamine pyrophosphorylase; Provisional
Pssm-ID: 240368 Cd Length: 482 Bit Score: 247.35 E-value: 2.58e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 93 GMDAIGRGEVCAIVLAGGQATRLGSSQPKGTIPLGINAsfGDSLLGIQAAKIALLQALAGEREHQNPG-KIHWAVMTSPG 171
Cdd:PTZ00339 98 GLEIIKKGEVAVLILAGGLGTRLGSDKPKGLLECTPVK--KKTLFQFHCEKVRRLEEMAVAVSGGGDDpTIYILVLTSSF 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 172 TEEATREHVKKlaaHHGFDFD-EQITIFSQDEIAAYDE-QGNFLLGTKGSVVAAPNGNGGLYSAISAH--LPRLRAKGIK 247
Cdd:PTZ00339 176 NHDQTRQFLEE---NNFFGLDkEQVIFFKQSSLPCYDEnTGRFIMSSQGSLCTAPGGNGDVFKALAKCseLMDIVRKGIK 252
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 248 YFHVYCVDNILCKVADPHFIGFAISNEA-DVATKCVPKQKGELVGSVCLDRGLPRVVEYSELGAELAEQKTP-DGKYLFG 325
Cdd:PTZ00339 253 YVQVISIDNILAKVLDPEFIGLASSFPAhDVLNKCVKREDDESVGVFCLKDYEWQVVEYTEINERILNNDELlTGELAFN 332
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 326 AGSIANHFFTMDFMDRVCSPS--SRLPYHRAHKKISYVNEQGTivkpeKPNGIKLEQFIFDVFELSKRFFIWEVARNEEF 403
Cdd:PTZ00339 333 YGNICSHIFSLDFLKKVAANRlyESTPYHAARKKIPYINGPTD-----KTMGIKLEAFIFDIFRYAKNVLILEVDREDEF 407
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17552518 404 SPLKNAQSVGTDCLSTCQRDLSNVNKLWLErvQAKVTATEKP------IYLKTIVSYNGENLQEL 462
Cdd:PTZ00339 408 APIKNADGAAADTILNAQKLLLSLHTRWLE--AALETVAGNPreglnlCEISPLVSYGGEGLFQY 470
|
|
| PLN02435 |
PLN02435 |
probable UDP-N-acetylglucosamine pyrophosphorylase |
4-464 |
2.71e-74 |
|
probable UDP-N-acetylglucosamine pyrophosphorylase
Pssm-ID: 215238 Cd Length: 493 Bit Score: 242.47 E-value: 2.71e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 4 TAPPKDEIISKFP--GSEPLLNFYNELSDAEKSKLFHQISTLNLSEAHQwFIDSADQRAPSTAEDLKPVLDSQHFVQAEL 81
Cdd:PLN02435 18 GAAPPQALLERLKdyGQEDAFALWDELSPEERDLLVRDIESLDLPRIDR-IIRCSLRSQGLPVPAIEPVPENSVSTVEER 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 82 HQVILDGLWNKGMDAIGRGEVCAIVLAGGQATRLGSSQPKGTIPLGINAsfGDSLLGIQAAKIALLQALAGEREHQNPGK 161
Cdd:PLN02435 97 TPEDRERWWKMGLKAISEGKLAVVLLSGGQGTRLGSSDPKGCFNIGLPS--GKSLFQLQAERILCVQRLAAQASSEGPGR 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 162 ---IHWAVMTSPGTEEATRehvKKLAAHHGFDFD-EQITIFSQDEIAAYDEQGNFLLGTKGSVVAAPNGNGGLYSAI--S 235
Cdd:PLN02435 175 pvtIHWYIMTSPFTDEATR---KFFESHKYFGLEaDQVTFFQQGTLPCVSKDGKFIMETPFKVAKAPDGNGGVYAALksS 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 236 AHLPRLRAKGIKYFHVYCVDNILCKVADPHFIGFAISNEADVATKCVPKQ-KGELVGS-VCLDRGLP-RVVEYSELGAEL 312
Cdd:PLN02435 252 RLLEDMASRGIKYVDCYGVDNALVRVADPTFLGYFIDKGVASAAKVVRKAyPQEKVGVfVRRGKGGPlTVVEYSELDQAM 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 313 A---EQKTpdGKYLFGAGSIANHFFTMDFMDRVCSPSSRLP-YHRAHKKISYVNeqGTIVkpekpnGIKLEQFIFDVFEL 388
Cdd:PLN02435 332 AsaiNQQT--GRLRYCWSNVCLHMFTLDFLNQVANGLEKDSiYHLAEKKIPSIH--GYTM------GLKLEQFIFDAFPY 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 389 SKRFFIWEVARNEEFSPLKNAQSVGTDCLSTCQRDLSNVNKLWLERVQAKVTATeKPIYLKTI-----VSYNGENLQELR 463
Cdd:PLN02435 402 APSTALFEVLREEEFAPVKNANGSNFDTPESARLLVLRLHTRWVVAAGGFLTHS-VPLYATGVevsplCSYAGENLEAIC 480
|
.
gi 17552518 464 H 464
Cdd:PLN02435 481 R 481
|
|
| UGPase_euk_like |
cd04180 |
Eukaryotic UGPase-like includes UDPase and UDPGlcNAc pyrophosphorylase enzymes; This family ... |
102-408 |
5.02e-42 |
|
Eukaryotic UGPase-like includes UDPase and UDPGlcNAc pyrophosphorylase enzymes; This family includes UDP-Glucose Pyrophosphorylase (UDPase) and UDPGlcNAc pyrophosphorylase enzymes. The two enzymes share significant sequence and structure similarity. UDP-Glucose Pyrophosphorylase catalyzes a reversible production of UDP-Glucose and pyrophosphate (PPi) from Glucose-1-phosphate and UTP. UDP-glucose plays pivotal roles in galactose utilization, in glycogen synthesis, and in the synthesis of the carbohydrate moieties of glycolipids , glycoproteins , and proteoglycans . UDP-N-acetylglucosamine (UDPGlcNAc) pyrophosphorylase (UAP) (also named GlcNAc1P uridyltransferase), catalyzes the reversible conversion of UTP and GlcNAc1P from PPi and UDPGlcNAc, which is a key precursor of N- and O-linked glycosylations and is essential for the synthesis of chitin (a major component of the fungal cell wall) and of the glycosylphosphatidylinositol (GPI) linker anchoring a variety of cell surface proteins to the plasma membrane. In bacteria, UDPGlcNAc represents an essential precursor for both peptidoglycan and lipopolysaccharide biosynthesis.
Pssm-ID: 133023 Cd Length: 266 Bit Score: 150.40 E-value: 5.02e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 102 VCAIVLAGGQATRLGSSQPKGTIPLGINAsfGDSLLGIQAAKIALLQALAgerehQNPGKIHWAVMTSPGTEEATREHVK 181
Cdd:cd04180 1 VAVVLLAGGLGTRLGKDGPKSSTDVGLPS--GQCFLQLIGEKILTLQEID-----LYSCKIPEQLMNSKYTHEKTQCYFE 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 182 KLAAHhgfdfDEQITIFSQDEIAAYDEQGNFLLGTKGSVVAAPNGNGGLYSAI--SAHLPRLRAKGIKYFHVYCVDNILC 259
Cdd:cd04180 74 KINQK-----NSYVITFMQGKLPLKNDDDARDPHNKTKCHLFPCGHGDVVLALihSGHLNKLLEKGYRYIHFIGVDNLLV 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 260 KVADPHFIGFAISNEADVATKCVPKQ-KGELVGSVCL-DRGLPRVVEYSELGAELAEQKTPDG------KYLFGAGSIAN 331
Cdd:cd04180 149 KVADPLFIGIAIQNRKAINQKVVPKTrNEESGGYRIAnINGRVQLLEYDQIKKLLKQKMVNNQipkdidDAPFFLFNTNN 228
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17552518 332 HFFTMDFMDRVcspssrlpyhrahkkisyVNeqgtivkpekpngikleqfifDVFELSKRFFIWEVARNEEFSPLKN 408
Cdd:cd04180 229 LINFLVEFKDR------------------VD---------------------DIIEFTDDIVGVMVHRAEEFAPVKN 266
|
|
| UDPGP |
pfam01704 |
UTP--glucose-1-phosphate uridylyltransferase; This family consists of UTP--glucose-1-phosphate ... |
107-411 |
1.82e-23 |
|
UTP--glucose-1-phosphate uridylyltransferase; This family consists of UTP--glucose-1-phosphate uridylyltransferases, EC:2.7.7.9. Also known as UDP-glucose pyrophosphorylase (UDPGP) and Glucose-1-phosphate uridylyltransferase. UTP--glucose-1-phosphate uridylyltransferase catalyzes the interconversion of MgUTP + glucose-1-phosphate and UDP-glucose + MgPPi. UDP-glucose is an important intermediate in mammalian carbohydrate interconversion involved in various metabolic roles depending on tissue type. In Dictyostelium (slime mold) mutants in this enzyme abort the development cycle. Also within the family is UDP-N-acetylglucosamine or AGX1 and two hypothetical proteins from Borrelia burgdorferi the lyme disease spirochaete Swiss:O51893 and Swiss:O51036.
Pssm-ID: 460300 Cd Length: 412 Bit Score: 102.21 E-value: 1.82e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 107 LAGGQATRLGSSQPKGTIPLGINASFgdslLGIQAAKIallqalagerEHQNPG---KIHWAVMTSPGTEEATREHVKKL 183
Cdd:pfam01704 59 LNGGLGTSMGCVGPKSLIEVRDGLTF----LDLIVQQI----------EHLNKKynvDVPLVLMNSFNTDEDTKKIIRKY 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 184 AAHHgfdfdEQITIFSQDEIAAYDEQGNFLLGTKGSVVA---APNGNGGLYSAI--SAHLPRLRAKGIKYFHVYCVDNiL 258
Cdd:pfam01704 125 KGHK-----VDILTFNQSRYPRIDKDTLLPVPKSADSDEeewYPPGHGDLYESLynSGLLDKLLAEGKEYLFVSNIDN-L 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 259 CKVADPHFIGFAISNEADVATKCVPKQKG-ELVGSVCLDRGLPRVVEYSELGAELAEQKTPDGKY-LFGAGSIanhFFTM 336
Cdd:pfam01704 199 GATVDLNILNYMVDNGAEFLMEVTDKTRAdVKGGTLIEYDGKLRLLEIAQVPKEHVDEFKSIKKFkIFNTNNI---WINL 275
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17552518 337 DFMDRVCSpSSRLPYHRA-HKKisYVNEQGTIVKPEKPNGIKLEQFifdvfelsKRFFIWEVARnEEFSPLKNAQS 411
Cdd:pfam01704 276 KALKRVVE-EGELQLEIIvNKK--TLDNGENVIQLETAVGAAIKNF--------KNAIGINVPR-SRFLPVKTTSD 339
|
|
| PLN02830 |
PLN02830 |
UDP-sugar pyrophosphorylase |
30-320 |
2.41e-11 |
|
UDP-sugar pyrophosphorylase
Pssm-ID: 215444 Cd Length: 615 Bit Score: 65.86 E-value: 2.41e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 30 DAEKSKLFHQISTLN----------LSEAHQWFIDSADQR------APSTAEDLKPVLDSQHFVQAElhqvildglwNKG 93
Cdd:PLN02830 53 DDDKRRLLEQVARLDesypgglaayVSNAKELLADSKEGVnpfegwTPSVPEGEVLEYGSEEFVELE----------EAG 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 94 MDAIGRgevCAIVL-AGGQATRLGSSQPKgtIPLGINASFGDSLLGIQAAKIALLQALAGEREHQNPGKIHWAVMTSPGT 172
Cdd:PLN02830 123 LREAGN---AAFVLvAGGLGERLGYSGIK--VALPTETATGTCYLQLYIESILALQERAKKRKAKKGRKIPLVIMTSDDT 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 173 EEATREHVKKlAAHHGFDFDeQITIFSQDEIA---------AYDEQGNFLLGTKgsvvaaPNGNGG----LYSaiSAHLP 239
Cdd:PLN02830 198 HARTLKLLER-NDYFGMDPD-QVTLLKQEKVAclmdndarlALDPNDPYKIQTK------PHGHGDvhalLYS--SGLLD 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 240 RLRAKGIKYFHVYCVDNILCKVADPHFIGFAISNEADVATKCVPKQKGELVGSVCL-----DRGLPRVVEYSELGAELAE 314
Cdd:PLN02830 268 KWLSAGKKWVVFFQDTNGLVFKAIPAALGVSATKGFDMNSLAVPRKAKEAIGAIAKlthkdGREMVINVEYNQLDPLLRA 347
|
....*.
gi 17552518 315 QKTPDG 320
Cdd:PLN02830 348 TGHPDG 353
|
|
| UGGPase |
cd06424 |
UGGPase catalyzes the synthesis of UDP-Glucose/UDP-Galactose; UGGPase: UDP-Galactose/Glucose ... |
105-320 |
2.63e-10 |
|
UGGPase catalyzes the synthesis of UDP-Glucose/UDP-Galactose; UGGPase: UDP-Galactose/Glucose Pyrophosphorylase catalyzes the reversible production of UDP-Glucose/UDP-Galactose and pyrophosphate (PPi) from Glucose-1-phosphate/Galactose-1-phosphate and UTP. Its dual substrate specificity distinguishes it from the single substrate enzyme UDP-glucose pyrophosphorylase. It may play a key role in the galactose metabolism in raffinose oligosaccharide (RFO) metabolizing plants. RFO raffinose is a major photoassimilate and is a galactosylderivative of sucrose (Suc) containing a galactose (Gal) moiety. Upon arriving at the sink tissue, the Gal moieties of the RFOs are initially removed by alpha-galactosidase and then are phosphorylated to Gal-1-P. Gal-1-P is converted to UDP-Gal. The UDP-Gal is further metabolized to UDP-Glc via an epimerase reaction. The UDP-Glc can be directly utilized in cell wall metabolism or in Suc synthesis. However, for the Suc synthesis UDP-Glc must be further metabolized to Glc-1-P. This can be carried out either by the UGPase in the reverse direction or by the dual substrate PPase itself operating in the reverse direction. According to the latter possibility, the three-step pathway of Gal-1-P to Glc-1-P could be carried out by a single PPase, functioning sequentially in reverse directions separated by the epimerase reaction.
Pssm-ID: 133046 Cd Length: 315 Bit Score: 61.70 E-value: 2.63e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 105 IVLAGGQATRLGSSQPKGTIPLgiNASFGDSLLGIQAAKIALLQALAGEREHQNpgkIHWAVMTSPGTEEATREHVKKLa 184
Cdd:cd06424 4 VLVAGGLGERLGYSGIKIGLPV--ELTTNTTYLQYYLNYIRAFQEASKKGEKME---IPFVIMTSDDTHSKTLKLLEEN- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 185 AHHGFDFDeQITIFSQDEIAAY-DEQGNFLLG--TKGSVVAAPNGNGGLYSAISAH--LPRLRAKGIKYFHVYCVDNILC 259
Cdd:cd06424 78 NYFGLEKD-QVHILKQEKVFCLiDNDAHLALDpdNTYSILTKPHGHGDVHTLLYNSglLKKWIEAGYKWLVFFQDTNALA 156
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17552518 260 KVADPHFIGFAISNEADVATKCVPKQKGELVGSVCL-----DRGLPRVVEYSELGAELAEQKTPDG 320
Cdd:cd06424 157 FKAIPAVLGVSATKSLDMNSLTVPRKPKEAIGALCKltknnGKSMTINVEYNQLDPLLRASGKDDG 222
|
|
| NTP_transf_3 |
pfam12804 |
MobA-like NTP transferase domain; This family includes the MobA protein (Molybdopterin-guanine ... |
104-239 |
6.62e-04 |
|
MobA-like NTP transferase domain; This family includes the MobA protein (Molybdopterin-guanine dinucleotide biosynthesis protein A). The family also includes a wide range of other NTP transferase domain.
Pssm-ID: 463715 [Multi-domain] Cd Length: 159 Bit Score: 40.26 E-value: 6.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 104 AIVLAGGQATRLGssQPKGTIPLGinasfGDSLLGIQAAKIA--------------LLQALAG--------EREHQNPGK 161
Cdd:pfam12804 1 AVILAGGRSSRMG--GDKALLPLG-----GKPLLERVLERLRpagdevvvvandeeVLAALAGlgvpvvpdPDPGQGPLA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 162 -IHWAVMTSPGTEEA----------TREHVKKLAAHHGFDfDEQITIFSQDeiaayDEQGNFLLGTKG--SVVAAPNGNG 228
Cdd:pfam12804 74 gLLAALRAAPGADAVlvlacdmpflTPELLRRLLAAAEES-GADIVVPVYD-----GGRGHPLLYRRRllPALEALLGDR 147
|
170
....*....|.
gi 17552518 229 GLYSAISAHLP 239
Cdd:pfam12804 148 GLRRLLRRLDE 158
|
|
| MobA |
COG0746 |
Molybdopterin-guanine dinucleotide biosynthesis protein A [Coenzyme transport and metabolism]; ... |
101-153 |
1.32e-03 |
|
Molybdopterin-guanine dinucleotide biosynthesis protein A [Coenzyme transport and metabolism]; Molybdopterin-guanine dinucleotide biosynthesis protein A is part of the Pathway/BioSystem: Molybdopterin biosynthesis
Pssm-ID: 440509 [Multi-domain] Cd Length: 188 Bit Score: 39.79 E-value: 1.32e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 17552518 101 EVCAIVLAGGQATRLGssQPKGTIPLGinasfGDSLLGIQaakIALLQALAGE 153
Cdd:COG0746 4 PITGVILAGGRSRRMG--QDKALLPLG-----GRPLLERV---LERLRPQVDE 46
|
|
| glmU |
PRK14353 |
bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate ... |
104-223 |
9.65e-03 |
|
bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU;
Pssm-ID: 184642 [Multi-domain] Cd Length: 446 Bit Score: 38.30 E-value: 9.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552518 104 AIVLAGGQATRLGSSQPKGTIPLGinasfGDSLLgiqAAKIALLQALAGEREhqnpgkihwAVMTSPGTEEatrehVKKL 183
Cdd:PRK14353 8 AIILAAGEGTRMKSSLPKVLHPVA-----GRPML---AHVLAAAASLGPSRV---------AVVVGPGAEA-----VAAA 65
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 17552518 184 AAhhgfDFDEQITIFSQDEiaaydeqgnfLLGTKGSVVAA 223
Cdd:PRK14353 66 AA----KIAPDAEIFVQKE----------RLGTAHAVLAA 91
|
|
| |
