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Conserved domains on  [gi|392894166|ref|NP_497449|]
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F-box domain-containing protein [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 120-257 2.48e-44

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


:

Pssm-ID: 396410  Cd Length: 141  Bit Score: 156.97  E-value: 2.48e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894166   120 QDIDAFLMCISKREKCVNLKRLMFERLSINDILFLIPFFNFQVL---QFWYSDTKDRFERITHLNQWGNTKSFGLWDSAL 196
Cdd:pfam01827    1 EKIIESFLNILKSKKCLHVKEISLSGLSFSEVASILPYFDAGTLeeiELSSESDEDQFEEIVELEQWKNAKSLKIEGSSL 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392894166   197 DSKLIERLFHFETISVGIRRFTVKTAIKIRDNLLKRSTFKQCIIRHTSRNYLNLAKVFKPD 257
Cdd:pfam01827   81 SSFPIEHLFHFEEFDIKLDSFSVEDAIKIRDILLKSSTFQSCTIRSPDLNPIEIAKVFDPD 141
WSN pfam02206
Domain of unknown function;
296-360 5.10e-20

Domain of unknown function;


:

Pssm-ID: 426657  Cd Length: 66  Bit Score: 84.81  E-value: 5.10e-20
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 392894166   296 FKSSLTKMQMISRITTGIYLQHGLSTGSITSDDLIPELLHFGSITPTQISAINTDKLSKIVEGIN 360
Cdd:pfam02206    2 LSLIVEKLSILARITNAISLQAGLIDGSIPVDDVISELLNLGSVTLSDIIKIDVDKLKELLEKLK 66
FBOX smart00256
A Receptor for Ubiquitination Targets;
9-43 2.08e-07

A Receptor for Ubiquitination Targets;


:

Pssm-ID: 197608  Cd Length: 41  Bit Score: 48.20  E-value: 2.08e-07
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 392894166      9 PITIAIEILEKLDPMDRLACRKVCRCLRTASDRFG 43
Cdd:smart00256    2 PDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHD 36
 
Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 120-257 2.48e-44

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


Pssm-ID: 396410  Cd Length: 141  Bit Score: 156.97  E-value: 2.48e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894166   120 QDIDAFLMCISKREKCVNLKRLMFERLSINDILFLIPFFNFQVL---QFWYSDTKDRFERITHLNQWGNTKSFGLWDSAL 196
Cdd:pfam01827    1 EKIIESFLNILKSKKCLHVKEISLSGLSFSEVASILPYFDAGTLeeiELSSESDEDQFEEIVELEQWKNAKSLKIEGSSL 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392894166   197 DSKLIERLFHFETISVGIRRFTVKTAIKIRDNLLKRSTFKQCIIRHTSRNYLNLAKVFKPD 257
Cdd:pfam01827   81 SSFPIEHLFHFEEFDIKLDSFSVEDAIKIRDILLKSSTFQSCTIRSPDLNPIEIAKVFDPD 141
WSN pfam02206
Domain of unknown function;
296-360 5.10e-20

Domain of unknown function;


Pssm-ID: 426657  Cd Length: 66  Bit Score: 84.81  E-value: 5.10e-20
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 392894166   296 FKSSLTKMQMISRITTGIYLQHGLSTGSITSDDLIPELLHFGSITPTQISAINTDKLSKIVEGIN 360
Cdd:pfam02206    2 LSLIVEKLSILARITNAISLQAGLIDGSIPVDDVISELLNLGSVTLSDIIKIDVDKLKELLEKLK 66
WSN smart00453
Worm-specific (usually) N-terminal domain;
294-362 2.75e-17

Worm-specific (usually) N-terminal domain;


Pssm-ID: 197734  Cd Length: 69  Bit Score: 77.24  E-value: 2.75e-17
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 392894166    294 DGFKSSLTKMQMISRITTGIYLQHGLSTGSITSDDLIPELLHfgsITPTQISAINTDKLSKIVEGINEL 362
Cdd:smart00453    1 SKLQTVIERLSMLARVTNAISLQAGLINGSIPIDDVIAELLN---IDSSKLSDIINVDLTKIDEGLNKL 66
FBOX smart00256
A Receptor for Ubiquitination Targets;
9-43 2.08e-07

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 48.20  E-value: 2.08e-07
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 392894166      9 PITIAIEILEKLDPMDRLACRKVCRCLRTASDRFG 43
Cdd:smart00256    2 PDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHD 36
F-box_CeFBXA-like cd22150
F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and ...
 5-50 7.48e-06

F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and similar proteins; The family includes a group of uncharacterized Caenorhabditis elegans F-box domain-containing proteins. They may be components of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438921  Cd Length: 46  Bit Score: 44.01  E-value: 7.48e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 392894166    5 LLSVPITIAIEILEKLDPMDRLACRKVCRCLRTASDRFGASFRKVK 50
Cdd:cd22150     1 LSDLPIEILNKILDKLDPIDRLVLRKVSRNLRDIVDNQDPGFKKIS 46
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 5-42 1.36e-04

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 40.22  E-value: 1.36e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 392894166     5 LLSVPITIAIEILEKLDPMDRLACRKVCRCLRTASDRF 42
Cdd:pfam00646    1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSL 38
 
Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 120-257 2.48e-44

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


Pssm-ID: 396410  Cd Length: 141  Bit Score: 156.97  E-value: 2.48e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894166   120 QDIDAFLMCISKREKCVNLKRLMFERLSINDILFLIPFFNFQVL---QFWYSDTKDRFERITHLNQWGNTKSFGLWDSAL 196
Cdd:pfam01827    1 EKIIESFLNILKSKKCLHVKEISLSGLSFSEVASILPYFDAGTLeeiELSSESDEDQFEEIVELEQWKNAKSLKIEGSSL 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392894166   197 DSKLIERLFHFETISVGIRRFTVKTAIKIRDNLLKRSTFKQCIIRHTSRNYLNLAKVFKPD 257
Cdd:pfam01827   81 SSFPIEHLFHFEEFDIKLDSFSVEDAIKIRDILLKSSTFQSCTIRSPDLNPIEIAKVFDPD 141
WSN pfam02206
Domain of unknown function;
296-360 5.10e-20

Domain of unknown function;


Pssm-ID: 426657  Cd Length: 66  Bit Score: 84.81  E-value: 5.10e-20
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 392894166   296 FKSSLTKMQMISRITTGIYLQHGLSTGSITSDDLIPELLHFGSITPTQISAINTDKLSKIVEGIN 360
Cdd:pfam02206    2 LSLIVEKLSILARITNAISLQAGLIDGSIPVDDVISELLNLGSVTLSDIIKIDVDKLKELLEKLK 66
WSN smart00453
Worm-specific (usually) N-terminal domain;
294-362 2.75e-17

Worm-specific (usually) N-terminal domain;


Pssm-ID: 197734  Cd Length: 69  Bit Score: 77.24  E-value: 2.75e-17
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 392894166    294 DGFKSSLTKMQMISRITTGIYLQHGLSTGSITSDDLIPELLHfgsITPTQISAINTDKLSKIVEGINEL 362
Cdd:smart00453    1 SKLQTVIERLSMLARVTNAISLQAGLINGSIPIDDVIAELLN---IDSSKLSDIINVDLTKIDEGLNKL 66
FBOX smart00256
A Receptor for Ubiquitination Targets;
9-43 2.08e-07

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 48.20  E-value: 2.08e-07
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 392894166      9 PITIAIEILEKLDPMDRLACRKVCRCLRTASDRFG 43
Cdd:smart00256    2 PDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHD 36
F-box_CeFBXA-like cd22150
F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and ...
 5-50 7.48e-06

F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and similar proteins; The family includes a group of uncharacterized Caenorhabditis elegans F-box domain-containing proteins. They may be components of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438921  Cd Length: 46  Bit Score: 44.01  E-value: 7.48e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 392894166    5 LLSVPITIAIEILEKLDPMDRLACRKVCRCLRTASDRFGASFRKVK 50
Cdd:cd22150     1 LSDLPIEILNKILDKLDPIDRLVLRKVSRNLRDIVDNQDPGFKKIS 46
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 5-42 1.36e-04

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 40.22  E-value: 1.36e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 392894166     5 LLSVPITIAIEILEKLDPMDRLACRKVCRCLRTASDRF 42
Cdd:pfam00646    1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSL 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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