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Conserved domains on  [gi|71998438|ref|NP_496974|]
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Serpentine Receptor, class H [Caenorhabditis elegans]

Protein Classification

class H serpentine receptor( domain architecture ID 10563391)

class H serpentine receptor (Srh) belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans, and is related to the Str, Stl, and Srd families of 7TM serpentine receptors

CATH:  1.20.1070.10
Gene Ontology:  GO:0004888
PubMed:  10673277|23140243

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
15-317 3.40e-88

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402095  Cd Length: 302  Bit Score: 267.10  E-value: 3.40e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998438    15 ASTDFLETGCHIGSVFMLTSSIYTLFLMAKKSPDTMKSSVPYMINLHVATMICDLTWAVIVLPMFFMPVIAAHASGILTW 94
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998438    95 VTRERNVILWPPFAVLGGMAACLITLFEHRHQAIVTRSWfVMKRKWTRRIIYPLFYAISINFGLVELLTIPeDQAHAKQK 174
Cdd:pfam10318  81 LGVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTNKK-RITWKKTRVLYLIFNYIIALLFLIPIYLNIP-DQEAAKLK 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998438   175 AFKQHPCLPPIFFDDTS-AVIQRDASLFNPHMYTCCFILSVLVCFYCLHVLWHLLPRNNPSMSSGTRKMLRNFFISMCVQ 253
Cdd:pfam10318 159 VLKKLPCLPPEFFDNPPvFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVKSSLSKKTRKLQKKFFIALIIQ 238
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71998438   254 VTIPIVVLLLPNLYWNISISFDYYSQELNNISIILFTLHGTSSSIAVIFIYKPYRVYTKKLIFY 317
Cdd:pfam10318 239 VSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
 
Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
15-317 3.40e-88

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 267.10  E-value: 3.40e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998438    15 ASTDFLETGCHIGSVFMLTSSIYTLFLMAKKSPDTMKSSVPYMINLHVATMICDLTWAVIVLPMFFMPVIAAHASGILTW 94
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998438    95 VTRERNVILWPPFAVLGGMAACLITLFEHRHQAIVTRSWfVMKRKWTRRIIYPLFYAISINFGLVELLTIPeDQAHAKQK 174
Cdd:pfam10318  81 LGVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTNKK-RITWKKTRVLYLIFNYIIALLFLIPIYLNIP-DQEAAKLK 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998438   175 AFKQHPCLPPIFFDDTS-AVIQRDASLFNPHMYTCCFILSVLVCFYCLHVLWHLLPRNNPSMSSGTRKMLRNFFISMCVQ 253
Cdd:pfam10318 159 VLKKLPCLPPEFFDNPPvFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVKSSLSKKTRKLQKKFFIALIIQ 238
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71998438   254 VTIPIVVLLLPNLYWNISISFDYYSQELNNISIILFTLHGTSSSIAVIFIYKPYRVYTKKLIFY 317
Cdd:pfam10318 239 VSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
 
Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
15-317 3.40e-88

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 267.10  E-value: 3.40e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998438    15 ASTDFLETGCHIGSVFMLTSSIYTLFLMAKKSPDTMKSSVPYMINLHVATMICDLTWAVIVLPMFFMPVIAAHASGILTW 94
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998438    95 VTRERNVILWPPFAVLGGMAACLITLFEHRHQAIVTRSWfVMKRKWTRRIIYPLFYAISINFGLVELLTIPeDQAHAKQK 174
Cdd:pfam10318  81 LGVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTNKK-RITWKKTRVLYLIFNYIIALLFLIPIYLNIP-DQEAAKLK 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998438   175 AFKQHPCLPPIFFDDTS-AVIQRDASLFNPHMYTCCFILSVLVCFYCLHVLWHLLPRNNPSMSSGTRKMLRNFFISMCVQ 253
Cdd:pfam10318 159 VLKKLPCLPPEFFDNPPvFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVKSSLSKKTRKLQKKFFIALIIQ 238
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71998438   254 VTIPIVVLLLPNLYWNISISFDYYSQELNNISIILFTLHGTSSSIAVIFIYKPYRVYTKKLIFY 317
Cdd:pfam10318 239 VSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
7TM_GPCR_Sri pfam10327
Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis ...
56-310 2.01e-10

Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sri is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 313539  Cd Length: 303  Bit Score: 61.02  E-value: 2.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998438    56 YMINLHVATMICDLTWAVIVLPMFFMPVIAAHASGIL-TW--VTRERNVILWppFAVLGGMAACLITLFEHRHQAIVTrs 132
Cdd:pfam10327  46 YLLYFQISCTLTDIHLTFLMQPIPLFPIIAGYCNGFLaTVfgISSHYLMTIF--VFLLSFQLESLLLCFVRKHQAIAK-- 121
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998438   133 wfVMKRKWTRRIIYPLFYAISINF-----GLVELLTIPEDQahakQKAF--KQHPCLPPIFFDDTSAVIQRdaslFNPHM 205
Cdd:pfam10327 122 --ILSKHVIPKWLYIFLYILCHIFpfltaFLFYQSGLSREE----QLEYvkENYPEYLSQFSSLPNFAIYD----YNPWL 191
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998438   206 Y---TCCFILSVLVCFYCLHVLWHL---LPRNNPSMSSGTRKMLRNFFISMCVQVTIPIVVLLLPNLYWNISISFDYYSQ 279
Cdd:pfam10327 192 IvfgILAIFGGSLSFLILVYLTVDMfrmLKRLRKKISAQTYQKHRAALRSLIAQFATSPVCILPPFAFVVVVLFPIEYSQ 271
                         250       260       270
                  ....*....|....*....|....*....|.
gi 71998438   280 ELNNISIILFTLHGTSSSIAVIFIYKPYRVY 310
Cdd:pfam10327 272 EISEILLAIFSTHSSVNSIVLILTTPPYRKF 302
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
194-308 9.42e-05

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 43.69  E-value: 9.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998438   194 IQRDASLFNPHMYTCCFILSVLVCFYCLHVLWHLLPRNNPSMSSGTRKMLRNFFISMCVQVTIPIVVLLLPNLYWNISIS 273
Cdd:pfam10317 173 LQSFPALINTLIMTIPVFPIPIIILILRRKILKLLNSNSVNMSPTTKAQHRQLIKGLTIQALLPLFSYIPGVTLYLLSQL 252
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 71998438   274 FDYYSQELNNISIILFTLHGTSSSIAVIFIYKPYR 308
Cdd:pfam10317 253 TGTEFLILEYFIFVLPALPPLLDPLITIYFVTPYR 287
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
207-312 1.21e-03

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 40.13  E-value: 1.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998438   207 TCCFILSVLVCFYCLHVLWHLLPRNNPSMSSGTRKMLRNFFISMCVQVTIPIVVLLLPNLYWNISISFDYYSQELNNISI 286
Cdd:pfam10326 202 TFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIIT 281
                          90       100
                  ....*....|....*....|....*.
gi 71998438   287 ILFTLHGTSSSIAVIFIYKPYRVYTK 312
Cdd:pfam10326 282 ATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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