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Conserved domains on  [gi|17537425|ref|NP_496116|]
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Homeobox domain-containing protein [Caenorhabditis elegans]

Protein Classification

homeobox protein( domain architecture ID 11021495)

homeobox protein with a paired box domain similar to mammalian Pax6, a transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas, and Drosophila gooseberry-neuro, which is involved in defining the polarity of embryonic segments

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_ARSR super family cl46857
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 48-101 6.00e-25

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


The actual alignment was detected with superfamily member smart00351:

Pssm-ID: 481197 [Multi-domain]  Cd Length: 125  Bit Score: 97.01  E-value: 6.00e-25
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 17537425     48 GTKPKVATPQVVAKIEQYKRDNPTIFAWEIREKLISEDVCT--TPPSVSSINRILR 101
Cdd:smart00351  70 GSKPKVATPKVVKKIADYKQENPGIFAWEIRDRLLSEGVCDkdNVPSVSSINRILR 125
Homeodomain pfam00046
Homeodomain;
204-260 1.78e-23

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 91.02  E-value: 1.78e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 17537425   204 RLSRSTFTNEQLQSLEEVFLRDPYPSPNERADLVKRTNLPEARIQVWFSNRRAKWRK 260
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
 
Name Accession Description Interval E-value
PAX smart00351
Paired Box domain;
48-101 6.00e-25

Paired Box domain;


Pssm-ID: 128645 [Multi-domain]  Cd Length: 125  Bit Score: 97.01  E-value: 6.00e-25
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 17537425     48 GTKPKVATPQVVAKIEQYKRDNPTIFAWEIREKLISEDVCT--TPPSVSSINRILR 101
Cdd:smart00351  70 GSKPKVATPKVVKKIADYKQENPGIFAWEIRDRLLSEGVCDkdNVPSVSSINRILR 125
PAX pfam00292
'Paired box' domain;
48-101 1.18e-23

'Paired box' domain;


Pssm-ID: 366005  Cd Length: 125  Bit Score: 93.78  E-value: 1.18e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 17537425    48 GTKPKVATPQVVAKIEQYKRDNPTIFAWEIREKLISEDVCT--TPPSVSSINRILR 101
Cdd:pfam00292  70 GSKPKVATPEVVTKIAEYKRENPSIFAWEIRDRLLKEGVCDndTVPSVSSINRILR 125
Homeodomain pfam00046
Homeodomain;
204-260 1.78e-23

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 91.02  E-value: 1.78e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 17537425   204 RLSRSTFTNEQLQSLEEVFLRDPYPSPNERADLVKRTNLPEARIQVWFSNRRAKWRK 260
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
PAX cd00131
Paired Box domain
 48-104 5.77e-23

Paired Box domain


Pssm-ID: 238076  Cd Length: 128  Bit Score: 92.10  E-value: 5.77e-23
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 17537425  48 GTKPKVATPQVVAKIEQYKRDNPTIFAWEIREKLISEDVCT--TPPSVSSINRILRTRA 104
Cdd:cd00131  70 GSKPRVATPEVVKKIEIYKQENPGMFAWEIRDRLLQEGVCDksNVPSVSSINRILRNKA 128
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 203-259 1.04e-20

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 83.45  E-value: 1.04e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 17537425    203 RRLSRSTFTNEQLQSLEEVFLRDPYPSPNERADLVKRTNLPEARIQVWFSNRRAKWR 259
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 204-262 2.40e-20

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 82.68  E-value: 2.40e-20
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 17537425 204 RLSRSTFTNEQLQSLEEVFLRDPYPSPNERADLVKRTNLPEARIQVWFSNRRAKWRKTN 262
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
211-295 6.25e-12

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 62.45  E-value: 6.25e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537425 211 TNEQLQSLEEVFLRDPYPSPNERADLVKRTNLPEARIQVWFSNRRAKWRKTNANGSDRDELRAERSETDD---------- 280
Cdd:COG5576  59 TDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRSGKVEQRPGEEEADLAKIgslstgqisi 138

                        90
                ....*....|....*..
gi 17537425 281 --ALSISSQSPSPGGGQ 295
Cdd:COG5576 139 ieTLEFSRTSYEEGGLQ 155
 
Name Accession Description Interval E-value
PAX smart00351
Paired Box domain;
48-101 6.00e-25

Paired Box domain;


Pssm-ID: 128645 [Multi-domain]  Cd Length: 125  Bit Score: 97.01  E-value: 6.00e-25
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 17537425     48 GTKPKVATPQVVAKIEQYKRDNPTIFAWEIREKLISEDVCT--TPPSVSSINRILR 101
Cdd:smart00351  70 GSKPKVATPKVVKKIADYKQENPGIFAWEIRDRLLSEGVCDkdNVPSVSSINRILR 125
PAX pfam00292
'Paired box' domain;
48-101 1.18e-23

'Paired box' domain;


Pssm-ID: 366005  Cd Length: 125  Bit Score: 93.78  E-value: 1.18e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 17537425    48 GTKPKVATPQVVAKIEQYKRDNPTIFAWEIREKLISEDVCT--TPPSVSSINRILR 101
Cdd:pfam00292  70 GSKPKVATPEVVTKIAEYKRENPSIFAWEIRDRLLKEGVCDndTVPSVSSINRILR 125
Homeodomain pfam00046
Homeodomain;
204-260 1.78e-23

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 91.02  E-value: 1.78e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 17537425   204 RLSRSTFTNEQLQSLEEVFLRDPYPSPNERADLVKRTNLPEARIQVWFSNRRAKWRK 260
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
PAX cd00131
Paired Box domain
 48-104 5.77e-23

Paired Box domain


Pssm-ID: 238076  Cd Length: 128  Bit Score: 92.10  E-value: 5.77e-23
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 17537425  48 GTKPKVATPQVVAKIEQYKRDNPTIFAWEIREKLISEDVCT--TPPSVSSINRILRTRA 104
Cdd:cd00131  70 GSKPRVATPEVVKKIEIYKQENPGMFAWEIRDRLLQEGVCDksNVPSVSSINRILRNKA 128
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 203-259 1.04e-20

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 83.45  E-value: 1.04e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 17537425    203 RRLSRSTFTNEQLQSLEEVFLRDPYPSPNERADLVKRTNLPEARIQVWFSNRRAKWR 259
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 204-262 2.40e-20

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 82.68  E-value: 2.40e-20
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 17537425 204 RLSRSTFTNEQLQSLEEVFLRDPYPSPNERADLVKRTNLPEARIQVWFSNRRAKWRKTN 262
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
211-295 6.25e-12

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 62.45  E-value: 6.25e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537425 211 TNEQLQSLEEVFLRDPYPSPNERADLVKRTNLPEARIQVWFSNRRAKWRKTNANGSDRDELRAERSETDD---------- 280
Cdd:COG5576  59 TDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRSGKVEQRPGEEEADLAKIgslstgqisi 138

                        90
                ....*....|....*..
gi 17537425 281 --ALSISSQSPSPGGGQ 295
Cdd:COG5576 139 ieTLEFSRTSYEEGGLQ 155
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 223-255 1.45e-05

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


Pssm-ID: 428673  Cd Length: 39  Bit Score: 41.35  E-value: 1.45e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 17537425   223 LRDPYPSPNERADLVKRTNLPEARIQVWFSNRR 255
Cdd:pfam05920   5 LHNPYPSEEEKAELAKETGLSRKQISNWFINAR 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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