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Conserved domains on  [gi|17535753|ref|NP_496050|]
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Serpentine receptor class alpha-7 [Caenorhabditis elegans]

Protein Classification

class alpha serpentine receptor( domain architecture ID 10489313)

class alpha serpentine receptor (Sra) belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

CATH:  1.20.1070.10
Gene Ontology:  GO:0004888|GO:0007606

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7TM_GPCR_Sra pfam02117
Serpentine type 7TM GPCR chemoreceptor Sra; Chemoreception is mediated in Caenorhabditis ...
1-328 5.88e-170

Serpentine type 7TM GPCR chemoreceptor Sra; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sra is part of the Sra superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 111054  Cd Length: 328  Bit Score: 474.91  E-value: 5.88e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535753     1 MSAPNCARKYDIARLSSLNFQISQYVYLSLISLTFIFSYFAVKIVHQKSIFQLSTKILLFHNLVSANLHQLLYLFSALRR 80
Cdd:pfam02117   1 MSNPKCASEDEIDRLSSLNFRIAQFIDLIAIIITFILTYFAIKIVFKKSIFQLSTKILLFQNLFYANLHQIFYGIEAIRM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535753    81 LNLAYFYIDEPCVPLISEADCLPYLKVLVTGISGMIYGQTGLLLERGCATFIKDYDKKTSMFVGIAISIAILFLSLITGK 160
Cdd:pfam02117  81 LYKSFFMLSEPCNILITEIDCAPYLEVLVAGISGMIYGQTGLLIERACATFIKKYKKKKSALPGVIISILVLICSIATGK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535753   161 IIIWDDPLQGYLLSCVSYPSQSVERSRLFASIYTFISSFNLVFSVLLRRYNKKLEYSTPFVVGPRFRKREVIDSTSTICF 240
Cdd:pfam02117 161 IIIWDDPLDGYVLACFIFPSKSVPRSNTFLSICTVLSLFNLVISVLILYYNKKLEYSTRFKVGARFQKREVIDSTSTICF 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535753   241 LTFVQFIFMFIYSFGIFTLKTIRSMLTYRQYYFIVVWFYTIPFIAALFPILLVYRIRSSHVSRVTIIKTFTKTKQTQEEH 320
Cdd:pfam02117 241 LTFSQFIFMFIYSFGVLTLRSIRENISPEQYYLWVVWLYTVPFIALSFPLLLIYRIRSTRSNRTRKIKEITSTKQTQEEH 320

                  ....*...
gi 17535753   321 IKQLKNVW 328
Cdd:pfam02117 321 IKQMKNMW 328
 
Name Accession Description Interval E-value
7TM_GPCR_Sra pfam02117
Serpentine type 7TM GPCR chemoreceptor Sra; Chemoreception is mediated in Caenorhabditis ...
1-328 5.88e-170

Serpentine type 7TM GPCR chemoreceptor Sra; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sra is part of the Sra superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 111054  Cd Length: 328  Bit Score: 474.91  E-value: 5.88e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535753     1 MSAPNCARKYDIARLSSLNFQISQYVYLSLISLTFIFSYFAVKIVHQKSIFQLSTKILLFHNLVSANLHQLLYLFSALRR 80
Cdd:pfam02117   1 MSNPKCASEDEIDRLSSLNFRIAQFIDLIAIIITFILTYFAIKIVFKKSIFQLSTKILLFQNLFYANLHQIFYGIEAIRM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535753    81 LNLAYFYIDEPCVPLISEADCLPYLKVLVTGISGMIYGQTGLLLERGCATFIKDYDKKTSMFVGIAISIAILFLSLITGK 160
Cdd:pfam02117  81 LYKSFFMLSEPCNILITEIDCAPYLEVLVAGISGMIYGQTGLLIERACATFIKKYKKKKSALPGVIISILVLICSIATGK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535753   161 IIIWDDPLQGYLLSCVSYPSQSVERSRLFASIYTFISSFNLVFSVLLRRYNKKLEYSTPFVVGPRFRKREVIDSTSTICF 240
Cdd:pfam02117 161 IIIWDDPLDGYVLACFIFPSKSVPRSNTFLSICTVLSLFNLVISVLILYYNKKLEYSTRFKVGARFQKREVIDSTSTICF 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535753   241 LTFVQFIFMFIYSFGIFTLKTIRSMLTYRQYYFIVVWFYTIPFIAALFPILLVYRIRSSHVSRVTIIKTFTKTKQTQEEH 320
Cdd:pfam02117 241 LTFSQFIFMFIYSFGVLTLRSIRENISPEQYYLWVVWLYTVPFIALSFPLLLIYRIRSTRSNRTRKIKEITSTKQTQEEH 320

                  ....*...
gi 17535753   321 IKQLKNVW 328
Cdd:pfam02117 321 IKQMKNMW 328
 
Name Accession Description Interval E-value
7TM_GPCR_Sra pfam02117
Serpentine type 7TM GPCR chemoreceptor Sra; Chemoreception is mediated in Caenorhabditis ...
1-328 5.88e-170

Serpentine type 7TM GPCR chemoreceptor Sra; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sra is part of the Sra superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 111054  Cd Length: 328  Bit Score: 474.91  E-value: 5.88e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535753     1 MSAPNCARKYDIARLSSLNFQISQYVYLSLISLTFIFSYFAVKIVHQKSIFQLSTKILLFHNLVSANLHQLLYLFSALRR 80
Cdd:pfam02117   1 MSNPKCASEDEIDRLSSLNFRIAQFIDLIAIIITFILTYFAIKIVFKKSIFQLSTKILLFQNLFYANLHQIFYGIEAIRM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535753    81 LNLAYFYIDEPCVPLISEADCLPYLKVLVTGISGMIYGQTGLLLERGCATFIKDYDKKTSMFVGIAISIAILFLSLITGK 160
Cdd:pfam02117  81 LYKSFFMLSEPCNILITEIDCAPYLEVLVAGISGMIYGQTGLLIERACATFIKKYKKKKSALPGVIISILVLICSIATGK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535753   161 IIIWDDPLQGYLLSCVSYPSQSVERSRLFASIYTFISSFNLVFSVLLRRYNKKLEYSTPFVVGPRFRKREVIDSTSTICF 240
Cdd:pfam02117 161 IIIWDDPLDGYVLACFIFPSKSVPRSNTFLSICTVLSLFNLVISVLILYYNKKLEYSTRFKVGARFQKREVIDSTSTICF 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535753   241 LTFVQFIFMFIYSFGIFTLKTIRSMLTYRQYYFIVVWFYTIPFIAALFPILLVYRIRSSHVSRVTIIKTFTKTKQTQEEH 320
Cdd:pfam02117 241 LTFSQFIFMFIYSFGVLTLRSIRENISPEQYYLWVVWLYTVPFIALSFPLLLIYRIRSTRSNRTRKIKEITSTKQTQEEH 320

                  ....*...
gi 17535753   321 IKQLKNVW 328
Cdd:pfam02117 321 IKQMKNMW 328
7TM_GPCR_Srab pfam10292
Serpentine type 7TM GPCR receptor class ab chemoreceptor; Chemoreception is mediated in ...
5-320 2.75e-06

Serpentine type 7TM GPCR receptor class ab chemoreceptor; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srab is part of the Sra superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'. The expression pattern of the srab genes is biologically intriguing. Of the six promoters successfully expressed in transgenic organizms, one was exclusively expressed in the tail phasmid neurons, two were exclusively expressed in a head amphid neuron, and two were expressed both in the head and tail neurons as well as a limited number of other cells.


Pssm-ID: 370953  Cd Length: 324  Bit Score: 48.42  E-value: 2.75e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535753     5 NCARKYDIARLSSLNFQISQYVYLSLISLTFIFsYFAVKIVHQKsIFQLSTKILLFHNLVSANLHQLLYLFsaLRRLNL- 83
Cdd:pfam10292   3 DCQEMAEIATSSFLRLSLLFNLILSIIALPVLI-WALWSIKKSK-LFHFNTRIIFQIHLFGFLIHCFGRII--LHGLDLy 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535753    84 AYFYIDEPCVPLISEADCLPYLKVLVTGISGMIYGQTGLLLERGCATFIKDYDKKTSMFVGI-----AISIAILFLSLIT 158
Cdd:pfam10292  79 NYFVPLDGCDMIPSIYRCFVLRLMYNFGLFLISATTVSLVIERYIATYRSSKYENRYKWYGIllaifQLSIALFFLYFLY 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535753   159 GKIIiWDDPLQGYllsCVSYPSQSVErSRLFASIYTFISSF--NLVFSVLLRRYNKKLEYSTPFVVGPRFRKREVIDSTS 236
Cdd:pfam10292 159 SDFK-FDGVTMYY---CWTSKPGNPY-SLNIPEIVIIVSQIvaRIGFRYLLRKNKKLRAKQKRSTLSNRYQLEQNLRSIT 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535753   237 TICFLTFVQFIFMFIYSFGIFTLKTIRSMLTYRQYYFIVVWFYTIPFIAALFPILLVYRIRSshvSRVTIIKTFTKTKQT 316
Cdd:pfam10292 234 TLKIFANLDTIFVVIQITGFLFLHFFGSSMSKPTYFALIELNHCLPLYAIISIIILYRRIKK---IRVKIKTSLEAHMQA 310

                  ....
gi 17535753   317 QEEH 320
Cdd:pfam10292 311 DFDH 314
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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