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Conserved domains on  [gi|71994629|ref|NP_495725|]
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Protein qua-1 [Caenorhabditis elegans]

Protein Classification

Hint domain-containing protein( domain architecture ID 708477)

Hint (Hedgehog/INTein) domain-containing protein similar to Caenorhabditis elegans protein qua-1 and warthog protein 1

CATH:  2.170.16.10
Gene Ontology:  GO:0016540|GO:0016539
PubMed:  19040769|9489693

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Hint super family cl25982
Hint module; This is an alignment of the Hint module in the Hedgehog proteins. It does not ...
 961-1124 6.76e-44

Hint module; This is an alignment of the Hint module in the Hedgehog proteins. It does not include any Inteins which also possess the Hint module.


The actual alignment was detected with superfamily member pfam01079:

Pssm-ID: 460051 [Multi-domain]  Cd Length: 212  Bit Score: 158.57  E-value: 6.76e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994629    961 CFSADSLVTTVTG-QKRMDELQIGDYVL-VPSSGNVLkYEKVEMFYHREPKTRTNFVVLYTKSGRKLSLTGRHLLPVAEC 1038
Cdd:pfam01079   13 CFPGDATVTLEDGgRKPMSELQPGDRVLaMDGGGQVV-YSPVLMFLDRDPEQRAEFVEIETDNGETLTLTPAHLVFVADC 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994629   1039 SQVEQYTMNPdgidvamresKYAEKARKGECVLSIDE-SGEVIADEIVRVGRMTNVGIYSPMTVEGSLIVDGVLSSCFSH 1117
Cdd:pfam01079   92 ERSSSALERA----------VFASRVRPGDCVLVPDTgGGELRPVRVVSVSTVEATGVYAPLTSHGTIVVNRVLASCYAV 161


                   ....*...
gi 71994629   1118 LESHS-AH 1124
Cdd:pfam01079  162 IDSHSlAH 169
 
Name Accession Description Interval E-value
Hint pfam01079
Hint module; This is an alignment of the Hint module in the Hedgehog proteins. It does not ...
 961-1124 6.76e-44

Hint module; This is an alignment of the Hint module in the Hedgehog proteins. It does not include any Inteins which also possess the Hint module.


Pssm-ID: 460051 [Multi-domain]  Cd Length: 212  Bit Score: 158.57  E-value: 6.76e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994629    961 CFSADSLVTTVTG-QKRMDELQIGDYVL-VPSSGNVLkYEKVEMFYHREPKTRTNFVVLYTKSGRKLSLTGRHLLPVAEC 1038
Cdd:pfam01079   13 CFPGDATVTLEDGgRKPMSELQPGDRVLaMDGGGQVV-YSPVLMFLDRDPEQRAEFVEIETDNGETLTLTPAHLVFVADC 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994629   1039 SQVEQYTMNPdgidvamresKYAEKARKGECVLSIDE-SGEVIADEIVRVGRMTNVGIYSPMTVEGSLIVDGVLSSCFSH 1117
Cdd:pfam01079   92 ERSSSALERA----------VFASRVRPGDCVLVPDTgGGELRPVRVVSVSTVEATGVYAPLTSHGTIVVNRVLASCYAV 161


                   ....*...
gi 71994629   1118 LESHS-AH 1124
Cdd:pfam01079  162 IDSHSlAH 169
Hint cd00081
Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins ...
 961-1114 2.34e-22

Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein, and the flanking polypeptide sequences - the exteins - are joined by a peptide bond. In addition to the autocatalytic splicing domain, many inteins contain an inserted endonuclease domain, which plays a role in spreading inteins. Hedgehog proteins are a major class of intercellular signaling molecules, which control inductive interactions during animal development. The mature signaling forms of hedgehog proteins are the N-terminal fragments, which are covalently linked to cholesterol at their C-termini. This modification is the result of an autoprocessing step catalyzed by the C-terminal fragments, which are aligned here.


Pssm-ID: 238035 [Multi-domain]  Cd Length: 136  Bit Score: 93.87  E-value: 2.34e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994629  961 CFSADSLVTTVTG-QKRMDELQI--GDYVLVPSSGNVLKYEKVEMFYHREpkTRTNFVVLYTKSGRKLSLTGRHLLPVAE 1037
Cdd:cd00081    1 CFTGDTLVLLEDGgRKKIEELVEkkGDKVLALDETGKLVFSKVLKVLRRD--YEKKFYKIKTESGREITLTPDHLLFVLE 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 71994629 1038 CSQVeqytmnpdgidvamrESKYAEKARKGECVLSidesgeVIADEIVRVGRMT-NVGIYSPMTVE-GSLIVDGVLSSC 1114
Cdd:cd00081   79 DGEL---------------KWVFASDLKPGDYVLV------PVLEKVKEIEEIEyTGGVYDLTVEDnHNFIANGVLVHN 136
HintN smart00306
Hint (Hedgehog/Intein) domain N-terminal region; Hedgehog/Intein domain, N-terminal region. ...
 960-1074 1.15e-21

Hint (Hedgehog/Intein) domain N-terminal region; Hedgehog/Intein domain, N-terminal region. Domain has been split to accommodate large insertions of endonucleases.


Pssm-ID: 197642 [Multi-domain]  Cd Length: 100  Bit Score: 90.79  E-value: 1.15e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994629     960 NCFSADSLVTTVT-GQKRMDELQIGDYVLVPSSGNvLKYEKVEMFYHREPKTRTNFVVLYTKSGRKLSLTGRHLLPVAEC 1038
Cdd:smart00306    1 GCFPGDTLVLTEDgGIKKIEELEEGDKVLALDEGT-LKYSPVKVFLVREPKGEKKFYRIKTENGREITLTPDHLLLVRDG 79

                            90       100       110
                    ....*....|....*....|....*....|....*.
gi 71994629    1039 SQVeqytmnpdgidvamrESKYAEKARKGECVLSID 1074
Cdd:smart00306   80 GKL---------------VWVFASELKPGDYVLVPR 100
 
Name Accession Description Interval E-value
Hint pfam01079
Hint module; This is an alignment of the Hint module in the Hedgehog proteins. It does not ...
 961-1124 6.76e-44

Hint module; This is an alignment of the Hint module in the Hedgehog proteins. It does not include any Inteins which also possess the Hint module.


Pssm-ID: 460051 [Multi-domain]  Cd Length: 212  Bit Score: 158.57  E-value: 6.76e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994629    961 CFSADSLVTTVTG-QKRMDELQIGDYVL-VPSSGNVLkYEKVEMFYHREPKTRTNFVVLYTKSGRKLSLTGRHLLPVAEC 1038
Cdd:pfam01079   13 CFPGDATVTLEDGgRKPMSELQPGDRVLaMDGGGQVV-YSPVLMFLDRDPEQRAEFVEIETDNGETLTLTPAHLVFVADC 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994629   1039 SQVEQYTMNPdgidvamresKYAEKARKGECVLSIDE-SGEVIADEIVRVGRMTNVGIYSPMTVEGSLIVDGVLSSCFSH 1117
Cdd:pfam01079   92 ERSSSALERA----------VFASRVRPGDCVLVPDTgGGELRPVRVVSVSTVEATGVYAPLTSHGTIVVNRVLASCYAV 161


                   ....*...
gi 71994629   1118 LESHS-AH 1124
Cdd:pfam01079  162 IDSHSlAH 169
Hint cd00081
Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins ...
 961-1114 2.34e-22

Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein, and the flanking polypeptide sequences - the exteins - are joined by a peptide bond. In addition to the autocatalytic splicing domain, many inteins contain an inserted endonuclease domain, which plays a role in spreading inteins. Hedgehog proteins are a major class of intercellular signaling molecules, which control inductive interactions during animal development. The mature signaling forms of hedgehog proteins are the N-terminal fragments, which are covalently linked to cholesterol at their C-termini. This modification is the result of an autoprocessing step catalyzed by the C-terminal fragments, which are aligned here.


Pssm-ID: 238035 [Multi-domain]  Cd Length: 136  Bit Score: 93.87  E-value: 2.34e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994629  961 CFSADSLVTTVTG-QKRMDELQI--GDYVLVPSSGNVLKYEKVEMFYHREpkTRTNFVVLYTKSGRKLSLTGRHLLPVAE 1037
Cdd:cd00081    1 CFTGDTLVLLEDGgRKKIEELVEkkGDKVLALDETGKLVFSKVLKVLRRD--YEKKFYKIKTESGREITLTPDHLLFVLE 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 71994629 1038 CSQVeqytmnpdgidvamrESKYAEKARKGECVLSidesgeVIADEIVRVGRMT-NVGIYSPMTVE-GSLIVDGVLSSC 1114
Cdd:cd00081   79 DGEL---------------KWVFASDLKPGDYVLV------PVLEKVKEIEEIEyTGGVYDLTVEDnHNFIANGVLVHN 136
HintN smart00306
Hint (Hedgehog/Intein) domain N-terminal region; Hedgehog/Intein domain, N-terminal region. ...
 960-1074 1.15e-21

Hint (Hedgehog/Intein) domain N-terminal region; Hedgehog/Intein domain, N-terminal region. Domain has been split to accommodate large insertions of endonucleases.


Pssm-ID: 197642 [Multi-domain]  Cd Length: 100  Bit Score: 90.79  E-value: 1.15e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71994629     960 NCFSADSLVTTVT-GQKRMDELQIGDYVLVPSSGNvLKYEKVEMFYHREPKTRTNFVVLYTKSGRKLSLTGRHLLPVAEC 1038
Cdd:smart00306    1 GCFPGDTLVLTEDgGIKKIEELEEGDKVLALDEGT-LKYSPVKVFLVREPKGEKKFYRIKTENGREITLTPDHLLLVRDG 79

                            90       100       110
                    ....*....|....*....|....*....|....*.
gi 71994629    1039 SQVeqytmnpdgidvamrESKYAEKARKGECVLSID 1074
Cdd:smart00306   80 GKL---------------VWVFASELKPGDYVLVPR 100
HintC smart00305
Hint (Hedgehog/Intein) domain C-terminal region; Hedgehog/Intein domain, C-terminal region. ...
 1076-1120 1.40e-05

Hint (Hedgehog/Intein) domain C-terminal region; Hedgehog/Intein domain, C-terminal region. Domain has been split to accommodate large insertions of endonucleases.


Pssm-ID: 197641  Cd Length: 46  Bit Score: 43.32  E-value: 1.40e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 71994629    1076 SGEVIADEIVRVGRMTNVGIYSP-MTVEGSLIVDGVLSSCFSHLES 1120
Cdd:smart00305    1 EGDFRFVRVKSIEETEYTGVYDPtVTENHNFIANGILVHNCAEIET 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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