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Conserved domains on  [gi|212645657|ref|NP_495440|]
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DNA topoisomerase-like protein cin-4 [Caenorhabditis elegans]

Protein Classification

DNA topoisomerase 2-like domain-containing protein( domain architecture ID 1000163)

DNA topoisomerase 2-like domain-containing protein; DNA topoisomerase 2 alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTZ00108 super family cl36510
DNA topoisomerase 2-like protein; Provisional
 19-792 0e+00

DNA topoisomerase 2-like protein; Provisional


The actual alignment was detected with superfamily member PTZ00108:

Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 909.43  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657   19 SKQMDDLNQKCPKRKTSKLKGIPKLEDANDAGTKNSQQCTLILTEGDSAKTLAVSGLSVVGRDKYGVFPFRRKLLNVCDL 98
Cdd:PTZ00108  398 AKLAAELNKKMKAGKKSRILGIPKLDDANDAGGKNSEECTLILTEGDSAKALALAGLSVVGRDYYGVFPLRGKLLNVRDA 477

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657   99 NVNQIADSAEVNAIIKILGLQYTKKYEtedDFKTLRYGKLLIMANHDSDGSQFKGLLLNFFHRFWPALFK-RDFVEDFIT 177
Cdd:PTZ00108  478 SLKQLMNNKEIQNLFKILGLDIGKKYE---DPKGLRYGSLMIMTDQDHDGSHIKGLLINMIHHFWPSLLKnPGFLKEFIT 554

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  178 PIAKAT-EGKEEVSFYSLPEYSEWRMNTDNwKSYTIKYYNGLGTLTSKEAKKCFSDMVRHRIRFKYNGADDDKAVNMAFS 256
Cdd:PTZ00108  555 PIVKATkKGNQVISFFTIPDFEKWKQTVGL-KGWKIKYYKGLGTSTDKEGKEYFSNIDKHRIRFVYVDDSDDDSIDLAFS 633

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  257 KKKIEARTDYLMKLMQ----DKNQRKqqglaeeclynketrfVTLKDFFNYEIVC-SW--NLHSIPCLVDGLKPGQRKVL 329
Cdd:PTZ00108  634 KKRVEDRKEWITNYKGgtyvDHSKKK----------------LTYSDFVNKELILfSIadNERSIPSLVDGLKPGQRKIL 697

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  330 FACFKRANKREVKVAQLAGAVAEISAYHHGEQSLMGTIVNLAQDYVGSHNINLLLPIGQFGTRLQGGKDSASARSIFAQL 409
Cdd:PTZ00108  698 FACFKRNLKNEIKVAQLSGYVSEHSAYHHGEQSLQQTIVGMAQNFVGSNNINLLYPCGQFGSRLQGGKDHAAARYIFTKL 777

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  410 SQVTRTLFPAHDDNVLRFLYEENQRIEPEWYCPIIPMVLVNGAQGTGTGWSTNIPNYNPRELVKNIKRLIAGEPQKALAP 489
Cdd:PTZ00108  778 SKITRYIFPEEDDPILDYLEDDGQSVEPFYYVPIIPMVLVNGAEGIGTGFSTSIPNYNPLDIIDNLRRRLNGEEVRPLVP 857

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  490 WYKNFRGKIIQIDPSRFACYGEVSVLDDNTIEITELPIKQWTQDYKEkVLEglmESSDKKSPVIVDYKEYHTDTTVKFVV 569
Cdd:PTZ00108  858 WYRGFKGTIERNPKGKFISKGIYEKVPDGTVEITELPIGKWTEDYKE-FLE---SETLKEKDVIVDYRDYSTANTVHFTV 933

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  570 KLSPGKLRELERgQDLHQVFKLQAVINTTCMVLFDAAGWLRTYTSPEAITQEFYDSRQEKYVQRKEYLLGVLQAQSKRLT 649
Cdd:PTZ00108  934 KLNDGVLEQWEE-EGIEKVFKLKSTISTTNMVLFDENGKIKKYSDALDILKEFYLVRLDLYKKRKEYLLGKLERELARLS 1012

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  650 NQARFILATINNKIVLENKKKTAIVDVLIKMKFDadpvkKWKEDQKLKELRESGEIELDEDDLAAVAVEEGEDISSAAKa 729
Cdd:PTZ00108 1013 NKVRFIKHVINGELVITNAKKKDLVKELKKLGYV-----RFKDIIKKKSEKITAEEEEGAEEDDEADDEDDEEELGAAV- 1086

                         730       740       750       760       770       780
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 212645657  730 vetklsDYDYLVGLALIKLSEEEKNKLIKESEEKMAEVRVLEKKTWQDLWITDLDNFMSELTS 792
Cdd:PTZ00108 1087 ------SYDYLLSMPIWSLTKEKVEKLNAELEKKEKELEKLKNTTPKDMWLEDLDKFEEALEE 1143
 
Name Accession Description Interval E-value
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 19-792 0e+00

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 909.43  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657   19 SKQMDDLNQKCPKRKTSKLKGIPKLEDANDAGTKNSQQCTLILTEGDSAKTLAVSGLSVVGRDKYGVFPFRRKLLNVCDL 98
Cdd:PTZ00108  398 AKLAAELNKKMKAGKKSRILGIPKLDDANDAGGKNSEECTLILTEGDSAKALALAGLSVVGRDYYGVFPLRGKLLNVRDA 477

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657   99 NVNQIADSAEVNAIIKILGLQYTKKYEtedDFKTLRYGKLLIMANHDSDGSQFKGLLLNFFHRFWPALFK-RDFVEDFIT 177
Cdd:PTZ00108  478 SLKQLMNNKEIQNLFKILGLDIGKKYE---DPKGLRYGSLMIMTDQDHDGSHIKGLLINMIHHFWPSLLKnPGFLKEFIT 554

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  178 PIAKAT-EGKEEVSFYSLPEYSEWRMNTDNwKSYTIKYYNGLGTLTSKEAKKCFSDMVRHRIRFKYNGADDDKAVNMAFS 256
Cdd:PTZ00108  555 PIVKATkKGNQVISFFTIPDFEKWKQTVGL-KGWKIKYYKGLGTSTDKEGKEYFSNIDKHRIRFVYVDDSDDDSIDLAFS 633

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  257 KKKIEARTDYLMKLMQ----DKNQRKqqglaeeclynketrfVTLKDFFNYEIVC-SW--NLHSIPCLVDGLKPGQRKVL 329
Cdd:PTZ00108  634 KKRVEDRKEWITNYKGgtyvDHSKKK----------------LTYSDFVNKELILfSIadNERSIPSLVDGLKPGQRKIL 697

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  330 FACFKRANKREVKVAQLAGAVAEISAYHHGEQSLMGTIVNLAQDYVGSHNINLLLPIGQFGTRLQGGKDSASARSIFAQL 409
Cdd:PTZ00108  698 FACFKRNLKNEIKVAQLSGYVSEHSAYHHGEQSLQQTIVGMAQNFVGSNNINLLYPCGQFGSRLQGGKDHAAARYIFTKL 777

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  410 SQVTRTLFPAHDDNVLRFLYEENQRIEPEWYCPIIPMVLVNGAQGTGTGWSTNIPNYNPRELVKNIKRLIAGEPQKALAP 489
Cdd:PTZ00108  778 SKITRYIFPEEDDPILDYLEDDGQSVEPFYYVPIIPMVLVNGAEGIGTGFSTSIPNYNPLDIIDNLRRRLNGEEVRPLVP 857

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  490 WYKNFRGKIIQIDPSRFACYGEVSVLDDNTIEITELPIKQWTQDYKEkVLEglmESSDKKSPVIVDYKEYHTDTTVKFVV 569
Cdd:PTZ00108  858 WYRGFKGTIERNPKGKFISKGIYEKVPDGTVEITELPIGKWTEDYKE-FLE---SETLKEKDVIVDYRDYSTANTVHFTV 933

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  570 KLSPGKLRELERgQDLHQVFKLQAVINTTCMVLFDAAGWLRTYTSPEAITQEFYDSRQEKYVQRKEYLLGVLQAQSKRLT 649
Cdd:PTZ00108  934 KLNDGVLEQWEE-EGIEKVFKLKSTISTTNMVLFDENGKIKKYSDALDILKEFYLVRLDLYKKRKEYLLGKLERELARLS 1012

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  650 NQARFILATINNKIVLENKKKTAIVDVLIKMKFDadpvkKWKEDQKLKELRESGEIELDEDDLAAVAVEEGEDISSAAKa 729
Cdd:PTZ00108 1013 NKVRFIKHVINGELVITNAKKKDLVKELKKLGYV-----RFKDIIKKKSEKITAEEEEGAEEDDEADDEDDEEELGAAV- 1086

                         730       740       750       760       770       780
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 212645657  730 vetklsDYDYLVGLALIKLSEEEKNKLIKESEEKMAEVRVLEKKTWQDLWITDLDNFMSELTS 792
Cdd:PTZ00108 1087 ------SYDYLLSMPIWSLTKEKVEKLNAELEKKEKELEKLKNTTPKDMWLEDLDKFEEALEE 1143
TOP4c smart00434
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
 295-781 2.78e-164

DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC


Pssm-ID: 214660 [Multi-domain]  Cd Length: 444  Bit Score: 484.38  E-value: 2.78e-164
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657   295 VTLKDFFNYE-IVCSW---NLHSIPCLVDGLKPGQRKVLFACFKRANKR-EVKVAQLAGAVAEISAYH-HGEQSLMGTIV 368
Cdd:smart00434   1 IDIEDFINKEyLDYSMsviNGRAIPDVRDGLKPVQRRILYAMFKRGLTPdEPKVKSARGVGDVMGKYHpHGDSSLYDTIV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657   369 NLAQDYVgsHNINLLLPIGQFGTRLqGGKDSASARSIFAQLSQVTRTLFPAHDDNVLRFLYE-ENQRIEPEWYCPIIPMV 447
Cdd:smart00434  81 RMAQDFS--NNYPLLDGQGNFGSRL-DGDDAAAMRYTETRLSPLARLLLPDIDKDTVDFVPNyDGQEIEPTVLPPIIPNL 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657   448 LVNGAQGTGTGWSTNIPNYNPRELVKNIKRLIAGEPQK----ALAPWYKNFRGKIIQIDPSRFACYGEVSVLDDNTIEIT 523
Cdd:smart00434 158 LVNGSSGIAVGMATNIPPHNLREVIDAVRRLIDNPDASidelMMIPWGPDFPTGGEIVGPGKYVVRGKIEIEDDNTIVIT 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657   524 ELPIKQWTQDYKEKVLEGLMEssDKKSPVIVDYKEYHTDTTVKFVVKLSPGKLRElERGQDLHQVFKLQAVINTTCMVLF 603
Cdd:smart00434 238 ELPYQVNTADLIEKIAELVKD--KKIEGIIDVRDESHDRTGVRIVIELKRGAMAE-VVLNGLYKLTKLQTTFSINMLALF 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657   604 DaAGWLRTYTSPEaITQEFYDSRQEKYVQRKEYLLGVLQaQSKRLTNQARFILATINNKIVLENKKKTAIVDVLIKMKFD 683
Cdd:smart00434 315 D-NGRPKKYNLKE-ILKEFLDHRLEVYTRRKEYLLGKLE-AERLHILEGLFIALSIIDEIIVLIRSSKDLAKEAKEKLME 391

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657   684 ADpvkkwkedqklkelresgeiELDEDdlaavaveegedissaakavetklsDYDYLVGLALIKLSEEEKNKLIKESEEK 763
Cdd:smart00434 392 RF--------------------ELSEI-------------------------QADAILDMRLRRLTKLEVEKLEKELKEL 426

                          490
                   ....*....|....*...
gi 212645657   764 MAEVRVLEKKTWQDLWIT 781
Cdd:smart00434 427 EKEIEDLEKILASEEWLN 444
TOP4c cd00187
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ...
 310-786 1.25e-156

DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.


Pssm-ID: 238111 [Multi-domain]  Cd Length: 445  Bit Score: 464.73  E-value: 1.25e-156
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657 310 NLHSIPCLVDGLKPGQRKVLFACFKR---ANKREVKVAQLAGAVAEISaYHHGEQSLMGTIVNLAQDYvgSHNINLLLPI 386
Cdd:cd00187    1 NGRALPDVRDGLKPVQRRILYAMFKRgltPDKPEKKVARLVGDVAGKY-HPHGDSSLYDTIVRMAQDF--SNNIPLLDPQ 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657 387 GQFGTRlqGGKDSASARSIFAQLSQVTRTLFPAHDDNVLRFLYE-ENQRIEPEWYCPIIPMVLVNGAQGTGTGWSTNIPN 465
Cdd:cd00187   78 GNFGSR--DGDDAAAMRYTETRLSPIARLLLPDIDDPTVDFVPNyDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPP 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657 466 YNPRELVKNIKRLIAGEP-------QKALAPWYKNFrGKIIQID---------PSRFACYGEVSVLDD---NTIEITELP 526
Cdd:cd00187  156 HNLREVIDALRALIDNPEasidelmEIIKGPDFPTG-GIIEGRAgireayetgRGRYIIRGKYEIEDDegrNTIEITELP 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657 527 IKQWTQDYKEKVLEGLmesSDKKSPVIVDYKEYHTDTTVKFVVKLSPGKLRELERgQDLHQVFKLQAVINtTCMVLFDAA 606
Cdd:cd00187  235 YQVNKAKLKEKIAELV---KDKKIEGISDVRDESDREGIRFVIELKRGAMAEVVL-NGLYKVTKLQTTFG-INMVAFDPN 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657 607 GWLRTYTsPEAITQEFYDSRQEKYVQRKEYLLGVLQAQSKRLTNQARFILA--TINNKIVLENKKKTAIVDVLIKMKFDa 684
Cdd:cd00187  310 GRPKKLN-LKEILQEFLDHRLEVYTRRKEYELGKAEARLHILEGLLKAILNidEVINLIRSSDEAKKALIEELEKLGFS- 387

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657 685 dpvkkwkEDQklkelresgeieldeddlaavaveegedissaakavetklsdYDYLVGLALIKLSEEEKNKLIKESEEKM 764
Cdd:cd00187  388 -------EIQ------------------------------------------ADAILDMRLRRLTKLEREKLLKELKELE 418

                        490       500
                 ....*....|....*....|....*..
gi 212645657 765 AEVRVLEKKT-----WQDLWITDLDNF 786
Cdd:cd00187  419 AEIEDLEKILaseerPKDLWKEELDEF 445
DNA_topoisoIV pfam00521
DNA gyrase/topoisomerase IV, subunit A;
313-784 3.86e-134

DNA gyrase/topoisomerase IV, subunit A;


Pssm-ID: 459843 [Multi-domain]  Cd Length: 432  Bit Score: 406.55  E-value: 3.86e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  313 SIPCLVDGLKPGQRKVLFACFK--RANKREVKVAQLAGAVaeISAYH-HGEQSLMGTIVNLAQDYVGshNINLLLPIGQF 389
Cdd:pfam00521   2 AIPDVRDGLKPVQRRILYAMFEllNLDKPYKKVARLVGDV--MGKYHpHGDASLYDAIVRMAQDFVG--NIPLLDGQGNF 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  390 GTRLQGGKDsASARSIFAQLSQVTRTLFPAHDDNVLRFLYE-ENQRIEPEWYCPIIPMVLVNGAQGTGTGWSTNIPNYNP 468
Cdd:pfam00521  78 GSRIDGDKD-AAMRYTETRLSKIARELFPDIDDDTVDYVPNyDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHNL 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  469 RELVKNIKRLIAGEPQKAL-----APWYKNFRGKIIQIDP-SRFACY-------GEVSVLDDNTIEITELPIKQWTQDYK 535
Cdd:pfam00521 157 REIIDALIALLDGPEATLLmkyimGPDFPTGGGIIGKGGIkEAYKTGrgkitvrAKVEIEDRKTIVITELPYGVWTSDLI 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  536 EKVLEGLmesSDKKSPVIVDYKEYhTDTTVKFVVKLSPGKLRELERGQdLHQVFKLQAVINTTCMVLFDAAgwlRTYTSP 615
Cdd:pfam00521 237 EKIEELV---KNGKIKGISDIRDE-SDRGVRIVIELKRGADPEVVLND-LYKKTKLQTSFSTNNLVLFDGG---PKYLGL 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  616 EAITQEFYDSRQEKYVQRKEYLLGVLQAQSKRLT------NQARFILATINNKIVLENKKKtaivdVLIKmkfdadpvkk 689
Cdd:pfam00521 309 KEILKEFLDHRLEVYERRKEYLLEKLEERLHILEgllialNNIDFVIEIIRGSIDRKKAKK-----NLIE---------- 373

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  690 wkedqklkelresgeiELDEDdlaavaveegedissaakavetklsDYDYLVGLALIKLSEEEKNKLIKESEEKMAEVRV 769
Cdd:pfam00521 374 ----------------ELSEI-------------------------QADYLLDMRLRRLTKEEVDKLLEEIDELEKEIAE 412

                         490       500
                  ....*....|....*....|
gi 212645657  770 LEKKTWQ-----DLWITDLD 784
Cdd:pfam00521 413 LEKLLASekklnDLWIEELD 432
GyrB COG0187
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair];
32-219 6.71e-16

DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair];


Pssm-ID: 439957 [Multi-domain]  Cd Length: 635  Bit Score: 82.00  E-value: 6.71e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  32 RKTSKLKGipKLEDAN------DAGTKNSQQCTLILTEGDSAktlavsGLSVV-GRD-KY-GVFPFRRKLLNVCDLNVNQ 102
Cdd:COG0187  390 RELVRRKS--ALESSGlpgklaDCSSKDPEESELFIVEGDSA------GGSAKqGRDrEFqAILPLRGKILNVEKARLDK 461

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657 103 IADSAEVNAIIKILGLQytkkyeTEDDF--KTLRYGKLLIMANHDSDGSQFKGLLLNFFHRFWPALFKRDFVedFI--TP 178
Cdd:COG0187  462 ILKNEEIRDLITALGTG------IGDDFdlEKLRYHKIIIMTDADVDGAHIRTLLLTFFYRYMRPLIEAGHV--YIaqPP 533

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 212645657 179 IAKATEGKEEVSFYSLPEYSEWRMNTDNWKSYTIKYYNGLG 219
Cdd:COG0187  534 LYRIKKGKKTYYAYSDAELDELLKELKGKKKVEIQRYKGLG 574
gyrA TIGR01063
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ...
 319-547 1.02e-15

DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273423 [Multi-domain]  Cd Length: 800  Bit Score: 81.59  E-value: 1.02e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  319 DGLKPGQRKVLFACFK---RANKREVKVAQLAGAVaeISAYH-HGEQSLMGTIVNLAQDYvgSHNINLLLPIGQFGTrlQ 394
Cdd:TIGR01063  32 DGLKPVHRRILYAMYElglTPDKPYKKSARIVGDV--MGKYHpHGDSAIYDTLVRMAQDF--SLRYPLVDGQGNFGS--I 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  395 GGKDSASARSIFAQLSQVTRTLFPAHDDNVLRFL--YEENQRiEPEWYCPIIPMVLVNGAQGTGTGWSTNIPNYNPRELV 472
Cdd:TIGR01063 106 DGDPPAAMRYTEARLTKIAEELLRDIDKETVDFVpnYDGSEQ-EPTVLPSRFPNLLVNGSSGIAVGMATNIPPHNLGEII 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  473 KNIKRLIAGE-------------P----------QKALAPWYKNFRGKIIQidpsRFACYGEVSVLDDNTIEITELP--- 526
Cdd:TIGR01063 185 DALLAYIDNPdisiqellevikgPdfptggiilgRSGIRSAYETGRGSIVI----RARAEIEEDSKGREAIIVTEIPyqv 260

                         250       260
                  ....*....|....*....|....*.
gi 212645657  527 -----IKQWTQDYKEKVLEGLMESSD 547
Cdd:TIGR01063 261 nkarlIEKIAELVREKKIEGISDIRD 286
 
Name Accession Description Interval E-value
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 19-792 0e+00

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 909.43  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657   19 SKQMDDLNQKCPKRKTSKLKGIPKLEDANDAGTKNSQQCTLILTEGDSAKTLAVSGLSVVGRDKYGVFPFRRKLLNVCDL 98
Cdd:PTZ00108  398 AKLAAELNKKMKAGKKSRILGIPKLDDANDAGGKNSEECTLILTEGDSAKALALAGLSVVGRDYYGVFPLRGKLLNVRDA 477

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657   99 NVNQIADSAEVNAIIKILGLQYTKKYEtedDFKTLRYGKLLIMANHDSDGSQFKGLLLNFFHRFWPALFK-RDFVEDFIT 177
Cdd:PTZ00108  478 SLKQLMNNKEIQNLFKILGLDIGKKYE---DPKGLRYGSLMIMTDQDHDGSHIKGLLINMIHHFWPSLLKnPGFLKEFIT 554

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  178 PIAKAT-EGKEEVSFYSLPEYSEWRMNTDNwKSYTIKYYNGLGTLTSKEAKKCFSDMVRHRIRFKYNGADDDKAVNMAFS 256
Cdd:PTZ00108  555 PIVKATkKGNQVISFFTIPDFEKWKQTVGL-KGWKIKYYKGLGTSTDKEGKEYFSNIDKHRIRFVYVDDSDDDSIDLAFS 633

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  257 KKKIEARTDYLMKLMQ----DKNQRKqqglaeeclynketrfVTLKDFFNYEIVC-SW--NLHSIPCLVDGLKPGQRKVL 329
Cdd:PTZ00108  634 KKRVEDRKEWITNYKGgtyvDHSKKK----------------LTYSDFVNKELILfSIadNERSIPSLVDGLKPGQRKIL 697

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  330 FACFKRANKREVKVAQLAGAVAEISAYHHGEQSLMGTIVNLAQDYVGSHNINLLLPIGQFGTRLQGGKDSASARSIFAQL 409
Cdd:PTZ00108  698 FACFKRNLKNEIKVAQLSGYVSEHSAYHHGEQSLQQTIVGMAQNFVGSNNINLLYPCGQFGSRLQGGKDHAAARYIFTKL 777

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  410 SQVTRTLFPAHDDNVLRFLYEENQRIEPEWYCPIIPMVLVNGAQGTGTGWSTNIPNYNPRELVKNIKRLIAGEPQKALAP 489
Cdd:PTZ00108  778 SKITRYIFPEEDDPILDYLEDDGQSVEPFYYVPIIPMVLVNGAEGIGTGFSTSIPNYNPLDIIDNLRRRLNGEEVRPLVP 857

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  490 WYKNFRGKIIQIDPSRFACYGEVSVLDDNTIEITELPIKQWTQDYKEkVLEglmESSDKKSPVIVDYKEYHTDTTVKFVV 569
Cdd:PTZ00108  858 WYRGFKGTIERNPKGKFISKGIYEKVPDGTVEITELPIGKWTEDYKE-FLE---SETLKEKDVIVDYRDYSTANTVHFTV 933

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  570 KLSPGKLRELERgQDLHQVFKLQAVINTTCMVLFDAAGWLRTYTSPEAITQEFYDSRQEKYVQRKEYLLGVLQAQSKRLT 649
Cdd:PTZ00108  934 KLNDGVLEQWEE-EGIEKVFKLKSTISTTNMVLFDENGKIKKYSDALDILKEFYLVRLDLYKKRKEYLLGKLERELARLS 1012

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  650 NQARFILATINNKIVLENKKKTAIVDVLIKMKFDadpvkKWKEDQKLKELRESGEIELDEDDLAAVAVEEGEDISSAAKa 729
Cdd:PTZ00108 1013 NKVRFIKHVINGELVITNAKKKDLVKELKKLGYV-----RFKDIIKKKSEKITAEEEEGAEEDDEADDEDDEEELGAAV- 1086

                         730       740       750       760       770       780
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 212645657  730 vetklsDYDYLVGLALIKLSEEEKNKLIKESEEKMAEVRVLEKKTWQDLWITDLDNFMSELTS 792
Cdd:PTZ00108 1087 ------SYDYLLSMPIWSLTKEKVEKLNAELEKKEKELEKLKNTTPKDMWLEDLDKFEEALEE 1143
PLN03128 PLN03128
DNA topoisomerase 2; Provisional
 19-791 0e+00

DNA topoisomerase 2; Provisional


Pssm-ID: 215593 [Multi-domain]  Cd Length: 1135  Bit Score: 890.60  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657   19 SKQMDDLnQKCPKRKTSKLKGIPKLEDANDAGTKNSQQCTLILTEGDSAKTLAVSGLSVVGRDKYGVFPFRRKLLNVCDL 98
Cdd:PLN03128  389 FKQQKEL-KKKDGAKRQRLTGIPKLDDANDAGGKKSKDCTLILTEGDSAKALAMSGLSVVGRDHYGVFPLRGKLLNVREA 467

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657   99 NVNQIADSAEVNAIIKILGLQYTKKYeTEDDFKTLRYGKLLIMANHDSDGSQFKGLLLNFFHRFWPALFKR-DFVEDFIT 177
Cdd:PLN03128  468 SHKQIMKNAEITNIKQILGLQFGKTY-DEENTKSLRYGHLMIMTDQDHDGSHIKGLIINFFHSFWPSLLKIpGFLVEFIT 546

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  178 PIAKATEGKEEVSFYSLPEYSEWRMNTD-NWKSYTIKYYNGLGTLTSKEAKKCFSDMVRHRIRFKYNGADDDKAVNMAFS 256
Cdd:PLN03128  547 PIVKATKGGKSLSFYTMPEYEAWKESLEgETKGWTIKYYKGLGTSTSEEAKEYFSNLDIHKKEFLWQSDEDGDLIDMAFS 626

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  257 KKKIEARTDYLmKLMQDKNQRKQQGlaeeclynketRFVTLKDFFNYEIVC---SWNLHSIPCLVDGLKPGQRKVLFACF 333
Cdd:PLN03128  627 KKRVEDRKIWL-NNYEPGTFLDQTG-----------NGISYSDFINKELILfsqADLARSIPSMVDGLKPSQRKVLFACF 694

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  334 KRANKREVKVAQLAGAVAEISAYHHGEQSLMGTIVNLAQDYVGSHNINLLLPIGQFGTRLQGGKDSASARSIFAQLSQVT 413
Cdd:PLN03128  695 KRNLKSEIKVAQLSGYVAEHSAYHHGEASLASTIIGMAQDFVGSNNINLLTPSGQFGTRLQGGKDAASARYIFTRLSPIT 774

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  414 RTLFPAHDDNVLRFLYEENQRIEPEWYCPIIPMVLVNGAQGTGTGWSTNIPNYNPRELVKNIKRLIAGEPQKALAPWYKN 493
Cdd:PLN03128  775 RALFPKDDDVLLNYLNEDGQSIEPEWYCPIIPMVLVNGSEGIGTGWSTFIPNYNPRDIIANIRRLLRGEELEPMHPWYRG 854

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  494 FRGKIIQIDPSRFACY---GEVSVLDDNTIEITELPIKQWTQDYKEkVLEGLMESSDKKSPVIVDYKEYHTDTTVKFVVK 570
Cdd:PLN03128  855 FKGTITEVSTSRSGSYtvtGIIEQIGDTTIRITELPVRKWTQDYKE-FLEALLTGTKKKEPEIKDFKENHTDTTVHFTVT 933

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  571 LSPGKLRELERGqDLHQVFKLQAVINTTCMVLFDAAGWLRTYTSPEAITQEFYDSRQEKYVQRKEYLLGVLQAQSKRLTN 650
Cdd:PLN03128  934 LSEEKMARALAE-GLEKKFKLSTTISTSNMHLFDKDGKIKKYDSPEDILEEFFHLRLDLYVKRKEVLLENLEYELKKLDN 1012

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  651 QARFILATINNKIVLENKKKTAIVDVLIKMKFDadpvkKWKEDQKLKELRESGEiELDEDDlaavaveEGEDISSAAKAv 730
Cdd:PLN03128 1013 KARFILAVVKGEIVVNNRKRAELLAELEEKGFD-----KFPKTAKISETNVVGD-RDGEAS-------EEEEASDNELA- 1078

                         730       740       750       760       770       780
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 212645657  731 etklSDYDYLVGLALIKLSEEEKNKLIKESEEKMAEVRVLEKKTWQDLWITDLDNFMSELT 791
Cdd:PLN03128 1079 ----KSYDYLLGMPISSLTLEKVDELRAERAKKETEVEELKKTTPEDLWRKDLDAFEEALD 1135
PLN03237 PLN03237
DNA topoisomerase 2; Provisional
 20-790 0e+00

DNA topoisomerase 2; Provisional


Pssm-ID: 215641 [Multi-domain]  Cd Length: 1465  Bit Score: 789.06  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657   20 KQMDDLnQKCPKRKTSKLKGIPKLEDANDAGTKNSQQCTLILTEGDSAKTLAVSGLSVVGRDKYGVFPFRRKLLNVCDLN 99
Cdd:PLN03237  416 KQSKEL-KKTDGAKTTRVTGIPKLEDANEAGGKNSEKCTLILTEGDSAKALAVAGLSVVGRNYYGVFPLRGKLLNVREAS 494

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  100 VNQIADSAEVNAIIKILGLQYTKKYETeddFKTLRYGKLLIMANHDSDGSQFKGLLLNFFHRFWPALFK-RDFVEDFITP 178
Cdd:PLN03237  495 HKQIMNNAEIENIKQILGLQHGKQYES---VKSLRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKvPSFLVEFITP 571

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  179 IAKAT-EGKEEVSFYSLPEYSEWRMN-TDNWKSYTIKYYNGLGTLTSKEAKKCFSDMVRHRIRFKYNGADDDKAVNMAFS 256
Cdd:PLN03237  572 IVKATrRGKKVLSFYSMPEYEEWKESlGGNATGWSIKYYKGLGTSTAKEGKEYFKNLGKHKKDFVWEDEQDGDAIELAFS 651

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  257 KKKIEARTDYLMKLMQ----DKNQRKqqglaeeclynketrfVTLKDFFNYE-IVCSWN--LHSIPCLVDGLKPGQRKVL 329
Cdd:PLN03237  652 KKKIEARKNWLRQYEPgthlDQTQKD----------------VKYSDFVNKElILFSMAdlQRSIPSMVDGLKPGQRKIL 715

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  330 FACFKRANKREVKVAQLAGAVAEISAYHHGEQSLMGTIVNLAQDYVGSHNINLLLPIGQFGTRLQGGKDSASARSIFAQL 409
Cdd:PLN03237  716 FCSFKRNFVKEAKVAQLSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRLQGGKDHASARYIFTRL 795

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  410 SQVTRTLFPAHDDNVLRFLYEENQRIEPEWYCPIIPMVLVNGAQGTGTGWSTNIPNYNPRELVKNIKRLIAGEPQKALAP 489
Cdd:PLN03237  796 SPITRFLFPKDDDILLDYLNEDGQSIEPTWYMPIIPTVLVNGAEGIGTGWSTFIPNYNPRDIVANIRRLLNGESMEPMHP 875

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  490 WYKNFRGKIIQIDP----SRFACYGEVSVLDDNTIEITELPIKQWTQDYKEkVLEGLMESSDK-KSPVIVDYKEYHTDTT 564
Cdd:PLN03237  876 WYRGFKGTIEKTASkeggCTYTITGLYEEVDETTLRITELPIRRWTDDYKE-FLESLKTDNNKnKDPFIKDVKAYNDDTT 954

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  565 VKFVVKLSPGKLReLERGQDLHQVFKLQAVINTTCMVLFDAAGWLRTYTSPEAITQEFYDSRQEKYVQRKEYLLGVLQAQ 644
Cdd:PLN03237  955 VHFEVILSEENML-AAKQEGLLKKFKLTTTISTSNMHLFDSKGVIKKYDTPEQILEEFFHLRLEYYEKRKEVLLKNLEFE 1033

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  645 SKRLTNQARFILATINNKIVLENKKKTAIVDVLIKMKFDADPVKkwkedQKLKELRESGEIEldeddlaavAVEEGEDIS 724
Cdd:PLN03237 1034 LLKLENKVRFILAVVDGEIIVNNRKKADLVEELRQKGFTPFPKK-----AKSVEAAVAGATD---------DAAEEEEEI 1099

                         730       740       750       760       770       780
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 212645657  725 SAAKAVETKLSDYDYLVGLALIKLSEEEKNKLIKESEEKMAEVRVLEKKTWQDLWITDLDNFMSEL 790
Cdd:PLN03237 1100 DVSSSSGVRGSDYDYLLSMAIGTLTLEKVQELCADRDKLNIEVEDLKKTTPKSLWLKDLDALEKEL 1165
TOP4c smart00434
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
 295-781 2.78e-164

DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC


Pssm-ID: 214660 [Multi-domain]  Cd Length: 444  Bit Score: 484.38  E-value: 2.78e-164
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657   295 VTLKDFFNYE-IVCSW---NLHSIPCLVDGLKPGQRKVLFACFKRANKR-EVKVAQLAGAVAEISAYH-HGEQSLMGTIV 368
Cdd:smart00434   1 IDIEDFINKEyLDYSMsviNGRAIPDVRDGLKPVQRRILYAMFKRGLTPdEPKVKSARGVGDVMGKYHpHGDSSLYDTIV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657   369 NLAQDYVgsHNINLLLPIGQFGTRLqGGKDSASARSIFAQLSQVTRTLFPAHDDNVLRFLYE-ENQRIEPEWYCPIIPMV 447
Cdd:smart00434  81 RMAQDFS--NNYPLLDGQGNFGSRL-DGDDAAAMRYTETRLSPLARLLLPDIDKDTVDFVPNyDGQEIEPTVLPPIIPNL 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657   448 LVNGAQGTGTGWSTNIPNYNPRELVKNIKRLIAGEPQK----ALAPWYKNFRGKIIQIDPSRFACYGEVSVLDDNTIEIT 523
Cdd:smart00434 158 LVNGSSGIAVGMATNIPPHNLREVIDAVRRLIDNPDASidelMMIPWGPDFPTGGEIVGPGKYVVRGKIEIEDDNTIVIT 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657   524 ELPIKQWTQDYKEKVLEGLMEssDKKSPVIVDYKEYHTDTTVKFVVKLSPGKLRElERGQDLHQVFKLQAVINTTCMVLF 603
Cdd:smart00434 238 ELPYQVNTADLIEKIAELVKD--KKIEGIIDVRDESHDRTGVRIVIELKRGAMAE-VVLNGLYKLTKLQTTFSINMLALF 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657   604 DaAGWLRTYTSPEaITQEFYDSRQEKYVQRKEYLLGVLQaQSKRLTNQARFILATINNKIVLENKKKTAIVDVLIKMKFD 683
Cdd:smart00434 315 D-NGRPKKYNLKE-ILKEFLDHRLEVYTRRKEYLLGKLE-AERLHILEGLFIALSIIDEIIVLIRSSKDLAKEAKEKLME 391

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657   684 ADpvkkwkedqklkelresgeiELDEDdlaavaveegedissaakavetklsDYDYLVGLALIKLSEEEKNKLIKESEEK 763
Cdd:smart00434 392 RF--------------------ELSEI-------------------------QADAILDMRLRRLTKLEVEKLEKELKEL 426

                          490
                   ....*....|....*...
gi 212645657   764 MAEVRVLEKKTWQDLWIT 781
Cdd:smart00434 427 EKEIEDLEKILASEEWLN 444
TOP4c cd00187
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ...
 310-786 1.25e-156

DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.


Pssm-ID: 238111 [Multi-domain]  Cd Length: 445  Bit Score: 464.73  E-value: 1.25e-156
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657 310 NLHSIPCLVDGLKPGQRKVLFACFKR---ANKREVKVAQLAGAVAEISaYHHGEQSLMGTIVNLAQDYvgSHNINLLLPI 386
Cdd:cd00187    1 NGRALPDVRDGLKPVQRRILYAMFKRgltPDKPEKKVARLVGDVAGKY-HPHGDSSLYDTIVRMAQDF--SNNIPLLDPQ 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657 387 GQFGTRlqGGKDSASARSIFAQLSQVTRTLFPAHDDNVLRFLYE-ENQRIEPEWYCPIIPMVLVNGAQGTGTGWSTNIPN 465
Cdd:cd00187   78 GNFGSR--DGDDAAAMRYTETRLSPIARLLLPDIDDPTVDFVPNyDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPP 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657 466 YNPRELVKNIKRLIAGEP-------QKALAPWYKNFrGKIIQID---------PSRFACYGEVSVLDD---NTIEITELP 526
Cdd:cd00187  156 HNLREVIDALRALIDNPEasidelmEIIKGPDFPTG-GIIEGRAgireayetgRGRYIIRGKYEIEDDegrNTIEITELP 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657 527 IKQWTQDYKEKVLEGLmesSDKKSPVIVDYKEYHTDTTVKFVVKLSPGKLRELERgQDLHQVFKLQAVINtTCMVLFDAA 606
Cdd:cd00187  235 YQVNKAKLKEKIAELV---KDKKIEGISDVRDESDREGIRFVIELKRGAMAEVVL-NGLYKVTKLQTTFG-INMVAFDPN 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657 607 GWLRTYTsPEAITQEFYDSRQEKYVQRKEYLLGVLQAQSKRLTNQARFILA--TINNKIVLENKKKTAIVDVLIKMKFDa 684
Cdd:cd00187  310 GRPKKLN-LKEILQEFLDHRLEVYTRRKEYELGKAEARLHILEGLLKAILNidEVINLIRSSDEAKKALIEELEKLGFS- 387

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657 685 dpvkkwkEDQklkelresgeieldeddlaavaveegedissaakavetklsdYDYLVGLALIKLSEEEKNKLIKESEEKM 764
Cdd:cd00187  388 -------EIQ------------------------------------------ADAILDMRLRRLTKLEREKLLKELKELE 418

                        490       500
                 ....*....|....*....|....*..
gi 212645657 765 AEVRVLEKKT-----WQDLWITDLDNF 786
Cdd:cd00187  419 AEIEDLEKILaseerPKDLWKEELDEF 445
DNA_topoisoIV pfam00521
DNA gyrase/topoisomerase IV, subunit A;
313-784 3.86e-134

DNA gyrase/topoisomerase IV, subunit A;


Pssm-ID: 459843 [Multi-domain]  Cd Length: 432  Bit Score: 406.55  E-value: 3.86e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  313 SIPCLVDGLKPGQRKVLFACFK--RANKREVKVAQLAGAVaeISAYH-HGEQSLMGTIVNLAQDYVGshNINLLLPIGQF 389
Cdd:pfam00521   2 AIPDVRDGLKPVQRRILYAMFEllNLDKPYKKVARLVGDV--MGKYHpHGDASLYDAIVRMAQDFVG--NIPLLDGQGNF 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  390 GTRLQGGKDsASARSIFAQLSQVTRTLFPAHDDNVLRFLYE-ENQRIEPEWYCPIIPMVLVNGAQGTGTGWSTNIPNYNP 468
Cdd:pfam00521  78 GSRIDGDKD-AAMRYTETRLSKIARELFPDIDDDTVDYVPNyDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHNL 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  469 RELVKNIKRLIAGEPQKAL-----APWYKNFRGKIIQIDP-SRFACY-------GEVSVLDDNTIEITELPIKQWTQDYK 535
Cdd:pfam00521 157 REIIDALIALLDGPEATLLmkyimGPDFPTGGGIIGKGGIkEAYKTGrgkitvrAKVEIEDRKTIVITELPYGVWTSDLI 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  536 EKVLEGLmesSDKKSPVIVDYKEYhTDTTVKFVVKLSPGKLRELERGQdLHQVFKLQAVINTTCMVLFDAAgwlRTYTSP 615
Cdd:pfam00521 237 EKIEELV---KNGKIKGISDIRDE-SDRGVRIVIELKRGADPEVVLND-LYKKTKLQTSFSTNNLVLFDGG---PKYLGL 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  616 EAITQEFYDSRQEKYVQRKEYLLGVLQAQSKRLT------NQARFILATINNKIVLENKKKtaivdVLIKmkfdadpvkk 689
Cdd:pfam00521 309 KEILKEFLDHRLEVYERRKEYLLEKLEERLHILEgllialNNIDFVIEIIRGSIDRKKAKK-----NLIE---------- 373

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  690 wkedqklkelresgeiELDEDdlaavaveegedissaakavetklsDYDYLVGLALIKLSEEEKNKLIKESEEKMAEVRV 769
Cdd:pfam00521 374 ----------------ELSEI-------------------------QADYLLDMRLRRLTKEEVDKLLEEIDELEKEIAE 412

                         490       500
                  ....*....|....*....|
gi 212645657  770 LEKKTWQ-----DLWITDLD 784
Cdd:pfam00521 413 LEKLLASekklnDLWIEELD 432
TOP2c smart00433
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE
 20-269 1.47e-85

TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE


Pssm-ID: 214659 [Multi-domain]  Cd Length: 594  Bit Score: 284.45  E-value: 1.47e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657    20 KQMDDLNQKCPKRKTSKLKGIPKLEDANDAGTKnsqQCTLILTEGDSAKTLAVSGLSvvgRDKYGVFPFRRKLLNVCDLN 99
Cdd:smart00433 348 AAAKKARELTRKKKLSSISLPGKLADASSAGPK---KCELFLVEGDSAGGSAKSGRD---RDFQAILPLRGKILNVEKAS 421

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657   100 VNQIADSAEVNAIIKILGLQYTKKYetedDFKTLRYGKLLIMANHDSDGSQFKGLLLNFFHRFWPALFKRDFVEDFITPI 179
Cdd:smart00433 422 LDKILKNEEIQALITALGLGIGKDF----DIEKLRYGKIIIMTDADVDGSHIKGLLLTFFYRYMPPLIEAGFVYIAIPPL 497

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657   180 AKATEGK--EEVSFYSLPEYSEWRMNTD-NWKSYTIKYYNGLGTLTSKEAKKCFSDMVRHRIRFKY-NGADDDKAVNMAF 255
Cdd:smart00433 498 YKVTKGKkkYVYSFYSLDEYEKWLEKTEgNKSKYEIQRYKGLGEMNADQLWETTMDPERRTLLFVTlDDADEADLIFSAL 577

                          250
                   ....*....|....
gi 212645657   256 SKKKIEARTDYLMK 269
Cdd:smart00433 578 MGDKVEPRKEWIEE 591
52 PHA02592
DNA topisomerase II medium subunit; Provisional
 296-786 9.30e-67

DNA topisomerase II medium subunit; Provisional


Pssm-ID: 222896 [Multi-domain]  Cd Length: 439  Bit Score: 229.17  E-value: 9.30e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657 296 TLKDFFNYE----IVCSWNLHSIPCLVDGLKPGQRKVLFAC--FKRANKREV-KVAQLAGAVAEISaYHHGEQSLMGTIV 368
Cdd:PHA02592   7 SLKSIVNNEaleyAMYTVEERAIPNLIDGLKPVQRFVIHRAleYAKGNKEKFdKVAAIAGGVADLG-YHHGETSAQDAGA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657 369 NLAQDYvgSHNINLLLPIGQFGTRLqgGKDSASARSIFAQLSQVTRTLFpahDDNVLRFLYEENQRIEPEWYCPIIPMVL 448
Cdd:PHA02592  86 LMANTW--NNNIPLLDGQGNFGSRL--VQKAAAARYIFARVHDNFRKIY---KDEDLAPVHEDPEHIPPAFYLPIIPMVL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657 449 VNGAQGTGTGWSTNIPNYNPRELVKNIKRLIAGEPQKALAPWYKNFRGKIIQIDPSRFACYGEVSVLDDNTIEITELPIK 528
Cdd:PHA02592 159 LNGVSGIATGYATNILPHSPKSVIKAVLAALNGKDITEPKVQFPEFKGEVVEIEPGSYEIRGTYELNGKTKLHITEIPVK 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657 529 QWTQDYKEkVLEGLMESSdkkspVIVDYKEYHTDtTVKFVVKLSPGKLRELERGQdLHQVFKLQAVINTTCMVLfDAAGW 608
Cdd:PHA02592 239 YDRETYVA-VLDPLEEKG-----KIVSYDDCTED-GFRFKVTLKREENEEATHEK-IMKDFGLIERVSQNITVI-NENGK 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657 609 LRTYTSPEAITQEFYDSRQEKYVQRKEYLLGVLQAQSKRLTNQARFILATINNKIVLENKKKTAIVdvlikmkfdadpvk 688
Cdd:PHA02592 310 LKVYENAEDLIRDFVEIRKTYVQKRIQYEIKETEEAFDLALAKAEFIKRVIAGEIVLQGKTRSELT-------------- 375

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657 689 kwKEDQKLKELREsgeieldeddlaavaveegedissaakavetklsDYDYLVGLALIKLSEEEKNKLIKESEEKMAEVR 768
Cdd:PHA02592 376 --EELSDNKDFGE----------------------------------YADKLVAMNIYSMTSDEREKLQKEAEELEKEHE 419

                        490
                 ....*....|....*...
gi 212645657 769 VLEKKTWQDLWITDLDNF 786
Cdd:PHA02592 420 YWKKTTAKKEYIKDLEEL 437
TOPRIM_TopoIIA cd03365
TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the ...
 57-177 2.91e-57

TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). This glutamate and two aspartates, cluster together to form a highly acid surface patch. The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.


Pssm-ID: 173785 [Multi-domain]  Cd Length: 120  Bit Score: 191.74  E-value: 2.91e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  57 CTLILTEGDSAKTLAVSGLSVVGRDKYGVFPFRRKLLNVCDLNVNQIADSAEVNAIIKILGLQYTKKyeTEDDFKTLRYG 136
Cdd:cd03365    1 CTLILTEGDSAKALAVAGLSVVGRDYYGVFPLRGKLLNVREASHKQIMENAEIQNIKKILGLQHGKS--DYESTKSLRYG 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 212645657 137 KLLIMANHDSDGSQFKGLLLNFFHRFWPALFKRD-FVEDFIT 177
Cdd:cd03365   79 RLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKIPgFLVEFIT 120
TOPRIM_C pfam16898
C-terminal associated domain of TOPRIM; TOPRIM_C is found as the C-terminal extension of the ...
 175-306 1.37e-49

C-terminal associated domain of TOPRIM; TOPRIM_C is found as the C-terminal extension of the TOPRIM domain, pfam01751 in metazoa.


Pssm-ID: 465302 [Multi-domain]  Cd Length: 127  Bit Score: 170.78  E-value: 1.37e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  175 FITPIAKATEGKEEVSFYSLPEYSEWRMNTDNWKSYTIKYYNGLGTLTSKEAKKCFSDMVRHRIRFKYNGADDDKAVNMA 254
Cdd:pfam16898   1 FITPIVKVTKGKEVISFFSLPEYEEWKESTPNLKGWKIKYYKGLGTSTSEEAKEYFSNLDKHRKEFKYLGDDDDEAIDLA 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 212645657  255 FSKKKIEARTDYLMKLMQdknqrkqqglaEECLYnKETRFVTLKDFFNYEIV 306
Cdd:pfam16898  81 FSKKKADDRKEWLRNFNP-----------GTYLD-HSTKEISYSDFINKELI 120
TOPRIM_TopoIIA_like cd01030
TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain ...
 57-177 2.56e-44

TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.


Pssm-ID: 173780 [Multi-domain]  Cd Length: 115  Bit Score: 155.36  E-value: 2.56e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  57 CTLILTEGDSAKTLAVSGLSVVgrdKYGVFPFRRKLLNVCDLNVNQIADSAEVNAIIKILGLQYTKKYEtedDFKTLRYG 136
Cdd:cd01030    1 CELILVEGDSAGGSAKQGRDRV---FQAVFPLRGKILNVEKASLKKILKNEEIQNIIKALGLGIGKDDF---DLDKLRYG 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 212645657 137 KLLIMANHDSDGSQFKGLLLNFFHRFWPALFKRDFVEDFIT 177
Cdd:cd01030   75 KIIIMTDADVDGSHIRTLLLTFFYRFWPSLLENGFLYIAQT 115
39 PHA02569
DNA topoisomerase II large subunit; Provisional
 31-234 1.02e-22

DNA topoisomerase II large subunit; Provisional


Pssm-ID: 177398 [Multi-domain]  Cd Length: 602  Bit Score: 103.68  E-value: 1.02e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  31 KRKTSKLKgIPKLEDANDAGTknSQQCTLILTEGDSAKTLAvsgLSVVGRDKYGVFPFRRKLLNVCDLNVNQIADSAEVN 110
Cdd:PHA02569 383 AKKAKKAK-VAKHIKANLIGK--DAETTLFLTEGDSAIGYL---IEVRDEELHGGYPLRGKVLNTWGMSYADILKNKELF 456

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657 111 AIIKILGLQYTkkyetEDDFKTlRYGKLLIMANHDSDGS-QFKGLLLNFFHRfWPALFKRDFVEDFITPIAKATEGKEEV 189
Cdd:PHA02569 457 DICAITGLVLG-----EKAENM-NYKNIAIMTDADVDGKgSIYPLLLAFFSR-WPELFEQGRIRFVKTPVIIAQVGKETK 529

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 212645657 190 SFYSLPEYSEWRmntDNWKSYTIKYYNGLGTLTSKEAKKCFSDMV 234
Cdd:PHA02569 530 WFYSLDEFEKAK---DSLKKWSIRYIKGLGSLRKSEYRRVINNPV 571
PRK05559 PRK05559
DNA topoisomerase IV subunit B; Reviewed
 31-219 1.96e-17

DNA topoisomerase IV subunit B; Reviewed


Pssm-ID: 235501 [Multi-domain]  Cd Length: 631  Bit Score: 86.69  E-value: 1.96e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  31 KRKTSKLKGIPKLEDANdagTKNSQQCTLILTEGDSAktlavSGLSVVGRDKY--GVFPFRRKLLNVCDLNVNQIADSAE 108
Cdd:PRK05559 393 KKKTSGPALPGKLADCT---SQDPERTELFLVEGDSA-----GGSAKQARDREfqAILPLRGKILNTWEASLDDVLANEE 464

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657 109 VNAIIKILGLQYTKKYETEDdfktLRYGKLLIMANHDSDGSQFKGLLLNFFHRFWPALFKRDFVedFI--TPIAKATEGK 186
Cdd:PRK05559 465 IHDIIVAIGIGPGDSFDLED----LRYGKIIIMTDADVDGAHIATLLLTFFYRHFPPLVEAGHV--YIalPPLYRVDKGK 538

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 212645657 187 EEVSFYSLPEYSEW--RMNTDNWKsYTIKYYNGLG 219
Cdd:PRK05559 539 KKIYALDEEEKEELlkKLGKKGGK-PEIQRFKGLG 572
PRK09631 PRK09631
DNA topoisomerase IV subunit A; Provisional
 313-633 2.01e-16

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 236598 [Multi-domain]  Cd Length: 635  Bit Score: 83.60  E-value: 2.01e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657 313 SIPCLVDGLKPGQRKVLFACFKRANKREVKVAQLAGavaEISAYH-HGEQSLMGTIVNLAqdyvgshNINLLLPI-GQFG 390
Cdd:PRK09631  24 AIPDVIDGLKPVQRRILHSLFEMHDGKFHKVANVVG---NTMKYHpHGDASIYEALVNLA-------NKDLFIDKqGNFG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657 391 TRLQGgkDSASA-RSIFAQLSQVTR-TLFPAHddnVLRFLYEENQR-IEPEWYCPIIPMVLVNGAQGTGTGWSTNIPNYN 467
Cdd:PRK09631  94 NLFTG--DPASAaRYIECRLTPLAKeVLYNKE---ITEYEPSYDGRnNEPLCLPAKIPVILIQGAEGIAVGMATKILPHN 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657 468 PRELVKNIKRLIAGEPQKAlapwYKNF-RGKIiqIDPSRFA-------CYGEVSVLDDNTIEITELPIKQWTqdykekvl 539
Cdd:PRK09631 169 FNEILQAVKSELLGESFAL----YPDFpTGGI--VDVSEYAdgngkvlVRAKIETKDEKTIVIREIPFGTTT-------- 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657 540 EGLMESSDK-------KSPVIVDYkeyhTDTTVKFVVKLSPGKLRElERGQDLHQVFKLQAVINTTCMVLFDAAGWlrTY 612
Cdd:PRK09631 235 ESLIASIEKaarkgkiKISSINDY----TAENVEIEIKLPRGVYAS-EVIEALYAYTDCEVSISVNLLVIKDRYPV--IY 307

                        330       340
                 ....*....|....*....|.
gi 212645657 613 TSPEAItqEFYDSRQEKYVQR 633
Cdd:PRK09631 308 TVTDII--KFHAEHLQKVLKM 326
GyrB COG0187
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair];
32-219 6.71e-16

DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair];


Pssm-ID: 439957 [Multi-domain]  Cd Length: 635  Bit Score: 82.00  E-value: 6.71e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  32 RKTSKLKGipKLEDAN------DAGTKNSQQCTLILTEGDSAktlavsGLSVV-GRD-KY-GVFPFRRKLLNVCDLNVNQ 102
Cdd:COG0187  390 RELVRRKS--ALESSGlpgklaDCSSKDPEESELFIVEGDSA------GGSAKqGRDrEFqAILPLRGKILNVEKARLDK 461

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657 103 IADSAEVNAIIKILGLQytkkyeTEDDF--KTLRYGKLLIMANHDSDGSQFKGLLLNFFHRFWPALFKRDFVedFI--TP 178
Cdd:COG0187  462 ILKNEEIRDLITALGTG------IGDDFdlEKLRYHKIIIMTDADVDGAHIRTLLLTFFYRYMRPLIEAGHV--YIaqPP 533

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 212645657 179 IAKATEGKEEVSFYSLPEYSEWRMNTDNWKSYTIKYYNGLG 219
Cdd:COG0187  534 LYRIKKGKKTYYAYSDAELDELLKELKGKKKVEIQRYKGLG 574
gyrA TIGR01063
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ...
 319-547 1.02e-15

DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273423 [Multi-domain]  Cd Length: 800  Bit Score: 81.59  E-value: 1.02e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  319 DGLKPGQRKVLFACFK---RANKREVKVAQLAGAVaeISAYH-HGEQSLMGTIVNLAQDYvgSHNINLLLPIGQFGTrlQ 394
Cdd:TIGR01063  32 DGLKPVHRRILYAMYElglTPDKPYKKSARIVGDV--MGKYHpHGDSAIYDTLVRMAQDF--SLRYPLVDGQGNFGS--I 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  395 GGKDSASARSIFAQLSQVTRTLFPAHDDNVLRFL--YEENQRiEPEWYCPIIPMVLVNGAQGTGTGWSTNIPNYNPRELV 472
Cdd:TIGR01063 106 DGDPPAAMRYTEARLTKIAEELLRDIDKETVDFVpnYDGSEQ-EPTVLPSRFPNLLVNGSSGIAVGMATNIPPHNLGEII 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  473 KNIKRLIAGE-------------P----------QKALAPWYKNFRGKIIQidpsRFACYGEVSVLDDNTIEITELP--- 526
Cdd:TIGR01063 185 DALLAYIDNPdisiqellevikgPdfptggiilgRSGIRSAYETGRGSIVI----RARAEIEEDSKGREAIIVTEIPyqv 260

                         250       260
                  ....*....|....*....|....*.
gi 212645657  527 -----IKQWTQDYKEKVLEGLMESSD 547
Cdd:TIGR01063 261 nkarlIEKIAELVREKKIEGISDIRD 286
gyrB PRK05644
DNA gyrase subunit B; Validated
 48-219 2.31e-12

DNA gyrase subunit B; Validated


Pssm-ID: 235542 [Multi-domain]  Cd Length: 638  Bit Score: 70.51  E-value: 2.31e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  48 DAGTKNSQQCTLILTEGDSAKTLAVSGlsvvgRDKY--GVFPFRRKLLNVCDLNVNQIADSAEVNAIIKILGLQYTKKYe 125
Cdd:PRK05644 412 DCSSKDPEESELYIVEGDSAGGSAKQG-----RDRRfqAILPLRGKILNVEKARLDKILKNEEIRALITALGTGIGDDF- 485

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657 126 tedDFKTLRYGKLLIMANHDSDGSQFKGLLLNFFHRFWPALFKRDFVedFIT--PIAKATEGKEEVsFYSLPEYSEW--R 201
Cdd:PRK05644 486 ---DISKLRYHKIIIMTDADVDGAHIRTLLLTFFYRYMRPLIEAGYV--YIAqpPLYKIKKGGKEY-AYSDEELDEIlaE 559

                        170
                 ....*....|....*...
gi 212645657 202 MNTDNWKSYTIKYYNGLG 219
Cdd:PRK05644 560 LKLKGNPKYGIQRYKGLG 577
PRK09630 PRK09630
DNA topoisomerase IV subunit A; Provisional
 313-473 5.81e-10

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 170022  Cd Length: 479  Bit Score: 62.60  E-value: 5.81e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657 313 SIPCLVDGLKPGQRKVLFACFKRANKREVKVAQLAGAVaeISAYHHGEQSLMGTIVNLAqdyvgshNINLLLPI-GQFGT 391
Cdd:PRK09630  24 AIPHILDGLKPVQRRLLWTLFRMDDGKMHKVANIAGRT--MALHPHGDAPIVEALVVLA-------NKGYLIDTqGNFGN 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657 392 RLQgGKDSASARSIFAQLSQVTRTLFPAHDDNVLRFLYEENQRiEPEWYCPIIPMVLVNGAQGTGTGWSTNIPNYNPREL 471
Cdd:PRK09630  95 PLT-GDPHAAARYIEARLSPLAKEVLFNTDLMTFHDSYDGREK-EPDILPAKLPLLLLHGVDGIAVGMTTKIFPHNFCEL 172


                 ..
gi 212645657 472 VK 473
Cdd:PRK09630 173 LE 174
PRK05560 PRK05560
DNA gyrase subunit A; Validated
 319-479 2.97e-09

DNA gyrase subunit A; Validated


Pssm-ID: 235502 [Multi-domain]  Cd Length: 805  Bit Score: 60.81  E-value: 2.97e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657 319 DGLKPGQRKVLFACFK---RANKREVKVAQLAGAVaeISAYH-HGEQSLMGTIVNLAQDYvgshniNLLLPI--GQ--FG 390
Cdd:PRK05560  36 DGLKPVHRRILYAMNElgnTPDKPYKKSARIVGDV--MGKYHpHGDSAVYDALVRMAQDF------SMRYPLvdGQgnFG 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657 391 TRlqGGkDSASA-RSIFAQLSQVtrtlfpAHD-------------DNvlrflYEENQRiEPEwYCPI-IPMVLVNGAQGT 455
Cdd:PRK05560 108 SI--DG-DPAAAmRYTEARMSKI------AHElladidketvdfvPN-----YDGSEQ-EPT-VLPArFPNLLVNGSSGI 171

                        170       180
                 ....*....|....*....|....
gi 212645657 456 GTGWSTNIPNYNPRELVKNIKRLI 479
Cdd:PRK05560 172 AVGMATNIPPHNLGEVIDACLALI 195
PRK05561 PRK05561
DNA topoisomerase 4 subunit A;
319-555 1.86e-08

DNA topoisomerase 4 subunit A;


Pssm-ID: 235503 [Multi-domain]  Cd Length: 742  Bit Score: 58.19  E-value: 1.86e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657 319 DGLKPGQRKVLFACFK---RANKREVKVAQLAGAVaeISAYH-HGEQSLMGTIVNLAQDYvgshniNLLLPI----GQFG 390
Cdd:PRK05561  41 DGLKPVQRRILYAMSElglTPDAKFKKSARVVGDV--LGKYHpHGDSSIYDAMVRMAQDF------SYRYPLvdgqGNFG 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657 391 TRlqGGKDSASARSIFAQLSQVTRTLFPAHDDNVLRFL--YeENQRIEPEWYCPIIPMVLVNGAQGTGTGWSTNIPNYNP 468
Cdd:PRK05561 113 SI--DGDPAAAMRYTEARLSPIAELLLEEIDEGTVDFVpnF-DGTLKEPTVLPARFPNLLLNGATGIAVGMATDIPPHNL 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657 469 RELVKNIKRLIA---------------------GE---PQKALAPWYKNFRGKII-----QIDPSRFacygevsvlDDNT 519
Cdd:PRK05561 190 REVIDAAIHLIDnpdatleelmefvpgpdfptgGEiitGRDGIRKAYETGRGSIRvrarwEIEDLAG---------GRWQ 260

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 212645657 520 IEITELPikqwtqdY---KEKVLE---GLMEssDKKSPVIVD 555
Cdd:PRK05561 261 IVITELP-------YqvsKAKLIEqiaELMN--AKKLPGIAD 293
GyrA COG0188
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
319-479 7.97e-08

DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];


Pssm-ID: 439958 [Multi-domain]  Cd Length: 804  Bit Score: 56.20  E-value: 7.97e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657 319 DGLKPGQRKVLFACFK---RANKREVKVAQLAGAVaeISAYH-HGEQSLMGTIVNLAQDYvgshniNLLLPI--GQ--FG 390
Cdd:COG0188   41 DGLKPVHRRILYAMHElglTPDKPYKKSARVVGDV--MGKYHpHGDSAVYDALVRMAQDF------SMRYPLvdGQgnFG 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657 391 TRlqGGkDSASA-RSIFAQLSQVTRTLfpahddnvLRFLYEE---------NQRIEPEwYCP-IIPMVLVNGAQGTGTGW 459
Cdd:COG0188  113 SI--DG-DPAAAmRYTEARLAKIAEEL--------LADIDKDtvdfvpnydGSEQEPT-VLPaRFPNLLVNGSSGIAVGM 180

                        170       180
                 ....*....|....*....|
gi 212645657 460 STNIPNYNPRELVKNIKRLI 479
Cdd:COG0188  181 ATNIPPHNLGEVIDACIALI 200
PRK13979 PRK13979
DNA topoisomerase IV subunit A; Provisional
 313-472 8.22e-08

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 237576 [Multi-domain]  Cd Length: 957  Bit Score: 56.27  E-value: 8.22e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657 313 SIPCLVDGLKPGQRKVLFACFKRA---NKREVKVAQLAGAVaeISAYH-HGEQSLMGTIVNLAQDYvgSHNINLLLPIGQ 388
Cdd:PRK13979  38 ALPDVRDGLKPVHRRILYGAYMLKafpDKPYYKSARIVGDI--LGKYHpHGDSSVYDAMVILAQDF--TTRMPLIDGHGN 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657 389 FGTrlQGGKDSASARSIFAQLSQVTRTLFPAHDDNVLRFL--YEENQRiEPEWYCPIIPMVLVNGAQGTGTGWSTNIPNY 466
Cdd:PRK13979 114 WGS--IDGDSAAAMRYTEARLTPIAMEMLRDIDKDVVNMVdnYSDSEK-EPEVLPARYPNLLVNGAFGIAVGLATNIPPH 190


                 ....*.
gi 212645657 467 NPRELV 472
Cdd:PRK13979 191 NLKEVI 196
PTZ00109 PTZ00109
DNA gyrase subunit b; Provisional
 3-259 2.46e-07

DNA gyrase subunit b; Provisional


Pssm-ID: 240272 [Multi-domain]  Cd Length: 903  Bit Score: 54.50  E-value: 2.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657   3 EEDRNVFTSIDKKGGGSKQMDD--------LNQKCPKRKTSKLKGipKLEDANDAGTKNSQqctLILTEGDSAktlAVSG 74
Cdd:PTZ00109 519 EFEPNLLLAIYNKSLAAKKAFEeakaakdlIRQKNNQYYSTILPG--KLVDCISDDIERNE---LFIVEGESA---AGNA 590

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657  75 LSVVGRDKYGVFPFRRKLLNVCDLNVN-QIADSAEVNAIIKILGLQYTKKYETEDDFK---------------------- 131
Cdd:PTZ00109 591 KQARNREFQAVLPLKGKILNIEKIKNNkKVFENSEIKLLITSIGLSVNPVTWRQYDLShgtkaskdesvqnnnstltkkk 670

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657 132 ------TLRYGKLLIMANHDSDGSQFKGLLLNFFHRFWPALFKRDFVEDFITPIAKATEGKEEvsfyslpeysEWRMNTD 205
Cdd:PTZ00109 671 nslfdtPLRYGKIILLTDADVDGEHLRILLLTLLYRFCPSLYEHGRVYVACPPLYRITNNRMK----------QFNVSTK 740

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 212645657 206 NWKSYTIKYY-----NGLGTLTSKEAKKCFSDMVRHrirfKYNGADDDKAVNMAFSKKK 259
Cdd:PTZ00109 741 NSKKYIYTWSdeelnVLIKLLNKDYSSKETTRSVEE----KGNAPDLDNEYEDEKLDNK 795
PRK12758 PRK12758
DNA gyrase/topoisomerase IV subunit A;
314-574 2.02e-06

DNA gyrase/topoisomerase IV subunit A;


Pssm-ID: 237192 [Multi-domain]  Cd Length: 869  Bit Score: 51.54  E-value: 2.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657 314 IPCLVDGLKPGQRKVLFACFKRANKREVKVAQLAGavaEISAYH-HGEQSLMGTIVNLAQDyvgshniNLLL-PIGQFGT 391
Cdd:PRK12758  44 VPHIEDGLKPVQRRILHSMKEMDDGRYNKVANVVG---HTMQYHpHGDASIGDALVQLGQK-------DLLIdTQGNWGN 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657 392 RLQGgkDSASA-RSIFAQLSQVT-RTLFpaHDDNVLRFLYEENQRIEPEWYCPIIPMVLVNGAQGTGTGWSTNIPNYNPR 469
Cdd:PRK12758 114 ILTG--DGAAApRYIEARLSKFAlEVVF--NPKTTEWQLSYDGRKKEPVTLPVKFPLLLAQGAEGIAVGLSTKILPHNFN 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212645657 470 ELVK-NIKRLiAGEPQKAlapwYKNFR-GKIIQI----DPSRfacYGEVSV------LDDNTIEITELPIKQWTQDykek 537
Cdd:PRK12758 190 ELIDaSIAYL-KGKEFKL----YPDFPtGGIIDVsnynDGER---GGRVRVrakiekLDKKTLVITEIPYGTTTSS---- 257

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 212645657 538 VLEGLMESSDK---KSPVIVDykeyHTDTTVKFVVKLSPG 574
Cdd:PRK12758 258 LIDSILKANDKgkiKIKKVED----NTAADVEILVHLAPG 293
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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