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Conserved domains on  [gi|71995462|ref|NP_495387|]
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EGF-like domain-containing protein [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 604-647 6.83e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.00  E-value: 6.83e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 71995462    604 RVLYSSDLEEPRAIAVDPEVGLIFWTDWGkKARIERSGMDGQHR 647
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 165-197 3.67e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.72  E-value: 3.67e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 71995462    165 KCPDNNFQCSNGNCIFKNWVCDGEEDCSDGSDE 197
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 212-247 2.94e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.98  E-value: 2.94e-09
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 71995462 212 CPPGEmWKCGSGECIPSRWRCDAEVDCKDHSDEKNC 247
Cdd:cd00112   1 CPPNE-FRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 36-67 4.02e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.59  E-value: 4.02e-09
                        10        20        30
                ....*....|....*....|....*....|..
gi 71995462  36 NSFQCQDGRCIPMSWRCDGDIDCQNEEDEKNC 67
Cdd:cd00112   4 NEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 562-604 1.12e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 51.45  E-value: 1.12e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 71995462    562 VLTGDKIHTPDGLAVDWVHDLLFWTDGGLDQINVLDMkNGKQR 604
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANL-DGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 647-690 1.79e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 51.06  E-value: 1.79e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 71995462    647 RTVIVEGdrVVWPNGLALDYVDKRVYWADAKIKSIFSCDYWGKN 690
Cdd:smart00135   1 RTLLSSG--LGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 259-290 1.55e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 45.28  E-value: 1.55e-06
                        10        20        30
                ....*....|....*....|....*....|..
gi 71995462 259 EFACKaSHNCINKAFVCDGELDCSDGSDEDDC 290
Cdd:cd00112   5 EFRCA-NGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 120-159 1.77e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 45.28  E-value: 1.77e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 71995462 120 CQEKQFQCeelsgDYSLCIPETWVCDGQRDCTNGKDEQNC 159
Cdd:cd00112   1 CPPNEFRC-----ANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 71-115 7.80e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 43.35  E-value: 7.80e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 71995462  71 CGAEEHKCGevksarssleRFKCIPNKWVCDGEFDCEDKSDEFQC 115
Cdd:cd00112   1 CPPNEFRCA----------NGRCIPSSWVCDGEDDCGDGSDEENC 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
431-461 1.58e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 1.58e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 71995462    431 DINECEIAGVCDQ--ICLNIPGSYRCACHAGYQ 461
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 320-342 1.32e-03

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 37.19  E-value: 1.32e-03
                        10        20
                ....*....|....*....|...
gi 71995462 320 CIPASSWCNGEEDCPDGGDEKEC 342
Cdd:cd00112  13 CIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 694-734 9.39e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 34.88  E-value: 9.39e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 71995462    694 VLHSHQyLRHPFSMAV--FEDRLFYTDWEHDgVITVNKFTGAD 734
Cdd:smart00135   2 TLLSSG-LGHPNGLAVdwIEGRLYWTDWGLD-VIEVANLDGTN 42
 
Name Accession Description Interval E-value
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 604-647 6.83e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.00  E-value: 6.83e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 71995462    604 RVLYSSDLEEPRAIAVDPEVGLIFWTDWGkKARIERSGMDGQHR 647
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 165-197 3.67e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.72  E-value: 3.67e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 71995462    165 KCPDNNFQCSNGNCIFKNWVCDGEEDCSDGSDE 197
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 624-666 4.58e-10

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 55.63  E-value: 4.58e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 71995462   624 GLIFWTDWGKKARIERSGMDGQHRTVIVEGDrVVWPNGLALDY 666
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDD-LQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 166-198 2.26e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 2.26e-09
                        10        20        30
                ....*....|....*....|....*....|...
gi 71995462 166 CPDNNFQCSNGNCIFKNWVCDGEEDCSDGSDEL 198
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 212-247 2.94e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.98  E-value: 2.94e-09
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 71995462 212 CPPGEmWKCGSGECIPSRWRCDAEVDCKDHSDEKNC 247
Cdd:cd00112   1 CPPNE-FRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 36-67 4.02e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.59  E-value: 4.02e-09
                        10        20        30
                ....*....|....*....|....*....|..
gi 71995462  36 NSFQCQDGRCIPMSWRCDGDIDCQNEEDEKNC 67
Cdd:cd00112   4 NEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 562-604 1.12e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 51.45  E-value: 1.12e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 71995462    562 VLTGDKIHTPDGLAVDWVHDLLFWTDGGLDQINVLDMkNGKQR 604
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANL-DGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
211-247 1.61e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.10  E-value: 1.61e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 71995462   211 QCPPGEmWKCGSGECIPSRWRCDAEVDCKDHSDEKNC 247
Cdd:pfam00057   2 TCSPNE-FQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 647-690 1.79e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 51.06  E-value: 1.79e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 71995462    647 RTVIVEGdrVVWPNGLALDYVDKRVYWADAKIKSIFSCDYWGKN 690
Cdd:smart00135   1 RTLLSSG--LGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
36-67 1.80e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 50.71  E-value: 1.80e-08
                          10        20        30
                  ....*....|....*....|....*....|..
gi 71995462    36 NSFQCQDGRCIPMSWRCDGDIDCQNEEDEKNC 67
Cdd:pfam00057   6 NEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 36-64 1.17e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 48.40  E-value: 1.17e-07
                           10        20
                   ....*....|....*....|....*....
gi 71995462     36 NSFQCQDGRCIPMSWRCDGDIDCQNEEDE 64
Cdd:smart00192   5 GEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
164-198 1.69e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.01  E-value: 1.69e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 71995462   164 SKCPDNNFQCSNGNCIFKNWVCDGEEDCSDGSDEL 198
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEE 35
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 570-676 2.38e-07

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 53.36  E-value: 2.38e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71995462 570 TPDGLAVDwVHDLLFWTDGGLDQINVLDMKNGKQRVLYSS---DLEEPRAIAVDPEvGLIFWTDwGKKARIERSGMDGQH 646
Cdd:cd14962  13 RPYGVAAD-GRGRIYVADTGRGAVFVFDLPNGKVFVIGNAgpnRFVSPIGVAIDAN-GNLYVSD-AELGKVFVFDRDGKF 89

                        90       100       110
                ....*....|....*....|....*....|
gi 71995462 647 RTVIVEGDRVVWPNGLALDYVDKRVYWADA 676
Cdd:cd14962  90 LRAIGAGALFKRPTGIAVDPAGKRLYVVDT 119
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 211-244 2.68e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 47.63  E-value: 2.68e-07
                           10        20        30
                   ....*....|....*....|....*....|....
gi 71995462    211 QCPPGEmWKCGSGECIPSRWRCDAEVDCKDHSDE 244
Cdd:smart00192   1 TCPPGE-FQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 259-290 1.55e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 45.28  E-value: 1.55e-06
                        10        20        30
                ....*....|....*....|....*....|..
gi 71995462 259 EFACKaSHNCINKAFVCDGELDCSDGSDEDDC 290
Cdd:cd00112   5 EFRCA-NGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 120-159 1.77e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 45.28  E-value: 1.77e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 71995462 120 CQEKQFQCeelsgDYSLCIPETWVCDGQRDCTNGKDEQNC 159
Cdd:cd00112   1 CPPNEFRC-----ANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 581-621 4.07e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 44.46  E-value: 4.07e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 71995462   581 DLLFWTDGGLDQ-INVLDMKNGKQRVLYSSDLEEPRAIAVDP 621
Cdd:pfam00058   1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
571-676 5.21e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 48.92  E-value: 5.21e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71995462 571 PDGLAVDWVHDLLFWTDGGLDQINVLDMKNGKqrVLYSSDL-EEPRAIAVDPEVGLIFWTDWGkkarierSGM------- 642
Cdd:COG3391 112 PRGLAVDPDGGRLYVADSGNGRVSVIDTATGK--VVATIPVgAGPHGIAVDPDGKRLYVANSG-------SNTvsvivsv 182

                        90       100       110
                ....*....|....*....|....*....|....*
gi 71995462 643 -DGQHRTVIVEGDRVVWPNGLALDYVDKRVYWADA 676
Cdd:COG3391 183 iDTATGKVVATIPVGGGPVGVAVSPDGRRLYVANR 217
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 71-115 7.80e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 43.35  E-value: 7.80e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 71995462  71 CGAEEHKCGevksarssleRFKCIPNKWVCDGEFDCEDKSDEFQC 115
Cdd:cd00112   1 CPPNEFRCA----------NGRCIPSSWVCDGEDDCGDGSDEENC 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
431-461 1.58e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 1.58e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 71995462    431 DINECEIAGVCDQ--ICLNIPGSYRCACHAGYQ 461
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
118-159 2.88e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 41.85  E-value: 2.88e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 71995462   118 VSCQEKQFQCEElsgdySLCIPETWVCDGQRDCTNGKDEQNC 159
Cdd:pfam00057   1 STCSPNEFQCGS-----GECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 259-287 3.21e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 41.46  E-value: 3.21e-05
                           10        20
                   ....*....|....*....|....*....
gi 71995462    259 EFACKaSHNCINKAFVCDGELDCSDGSDE 287
Cdd:smart00192   6 EFQCD-NGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 120-156 3.21e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 41.46  E-value: 3.21e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 71995462    120 CQEKQFQCeelsgDYSLCIPETWVCDGQRDCTNGKDE 156
Cdd:smart00192   2 CPPGEFQC-----DNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
71-115 5.68e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 41.08  E-value: 5.68e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 71995462    71 CGAEEHKCGEVKsarsslerfkCIPNKWVCDGEFDCEDKSDEFQC 115
Cdd:pfam00057   3 CSPNEFQCGSGE----------CIPRSWVCDGDPDCGDGSDEENC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 431-461 1.06e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.06e-04
                        10        20        30
                ....*....|....*....|....*....|...
gi 71995462 431 DINECEIAGVCD--QICLNIPGSYRCACHAGYQ 461
Cdd:cd00054   1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYT 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 92-112 1.54e-04

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 39.54  E-value: 1.54e-04
                           10        20
                   ....*....|....*....|.
gi 71995462     92 KCIPNKWVCDGEFDCEDKSDE 112
Cdd:smart00192  13 RCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
253-290 3.17e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 38.77  E-value: 3.17e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 71995462   253 TCKlAEEFACkASHNCINKAFVCDGELDCSDGSDEDDC 290
Cdd:pfam00057   2 TCS-PNEFQC-GSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 320-342 1.32e-03

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 37.19  E-value: 1.32e-03
                        10        20
                ....*....|....*....|...
gi 71995462 320 CIPASSWCNGEEDCPDGGDEKEC 342
Cdd:cd00112  13 CIPSSWVCDGEDDCGDGSDEENC 35
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 441-463 4.44e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 35.68  E-value: 4.44e-03
                          10        20
                  ....*....|....*....|...
gi 71995462   441 CDQICLNIPGSYRCACHAGYQIS 463
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQ 30
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 694-734 9.39e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 34.88  E-value: 9.39e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 71995462    694 VLHSHQyLRHPFSMAV--FEDRLFYTDWEHDgVITVNKFTGAD 734
Cdd:smart00135   2 TLLSSG-LGHPNGLAVdwIEGRLYWTDWGLD-VIEVANLDGTN 42
 
Name Accession Description Interval E-value
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 604-647 6.83e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.00  E-value: 6.83e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 71995462    604 RVLYSSDLEEPRAIAVDPEVGLIFWTDWGkKARIERSGMDGQHR 647
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 165-197 3.67e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.72  E-value: 3.67e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 71995462    165 KCPDNNFQCSNGNCIFKNWVCDGEEDCSDGSDE 197
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 624-666 4.58e-10

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 55.63  E-value: 4.58e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 71995462   624 GLIFWTDWGKKARIERSGMDGQHRTVIVEGDrVVWPNGLALDY 666
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDD-LQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 166-198 2.26e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 2.26e-09
                        10        20        30
                ....*....|....*....|....*....|...
gi 71995462 166 CPDNNFQCSNGNCIFKNWVCDGEEDCSDGSDEL 198
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 212-247 2.94e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.98  E-value: 2.94e-09
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 71995462 212 CPPGEmWKCGSGECIPSRWRCDAEVDCKDHSDEKNC 247
Cdd:cd00112   1 CPPNE-FRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 36-67 4.02e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.59  E-value: 4.02e-09
                        10        20        30
                ....*....|....*....|....*....|..
gi 71995462  36 NSFQCQDGRCIPMSWRCDGDIDCQNEEDEKNC 67
Cdd:cd00112   4 NEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 562-604 1.12e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 51.45  E-value: 1.12e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 71995462    562 VLTGDKIHTPDGLAVDWVHDLLFWTDGGLDQINVLDMkNGKQR 604
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANL-DGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
211-247 1.61e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.10  E-value: 1.61e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 71995462   211 QCPPGEmWKCGSGECIPSRWRCDAEVDCKDHSDEKNC 247
Cdd:pfam00057   2 TCSPNE-FQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 647-690 1.79e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 51.06  E-value: 1.79e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 71995462    647 RTVIVEGdrVVWPNGLALDYVDKRVYWADAKIKSIFSCDYWGKN 690
Cdd:smart00135   1 RTLLSSG--LGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
36-67 1.80e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 50.71  E-value: 1.80e-08
                          10        20        30
                  ....*....|....*....|....*....|..
gi 71995462    36 NSFQCQDGRCIPMSWRCDGDIDCQNEEDEKNC 67
Cdd:pfam00057   6 NEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 36-64 1.17e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 48.40  E-value: 1.17e-07
                           10        20
                   ....*....|....*....|....*....
gi 71995462     36 NSFQCQDGRCIPMSWRCDGDIDCQNEEDE 64
Cdd:smart00192   5 GEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
164-198 1.69e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.01  E-value: 1.69e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 71995462   164 SKCPDNNFQCSNGNCIFKNWVCDGEEDCSDGSDEL 198
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEE 35
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 570-676 2.38e-07

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 53.36  E-value: 2.38e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71995462 570 TPDGLAVDwVHDLLFWTDGGLDQINVLDMKNGKQRVLYSS---DLEEPRAIAVDPEvGLIFWTDwGKKARIERSGMDGQH 646
Cdd:cd14962  13 RPYGVAAD-GRGRIYVADTGRGAVFVFDLPNGKVFVIGNAgpnRFVSPIGVAIDAN-GNLYVSD-AELGKVFVFDRDGKF 89

                        90       100       110
                ....*....|....*....|....*....|
gi 71995462 647 RTVIVEGDRVVWPNGLALDYVDKRVYWADA 676
Cdd:cd14962  90 LRAIGAGALFKRPTGIAVDPAGKRLYVVDT 119
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 211-244 2.68e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 47.63  E-value: 2.68e-07
                           10        20        30
                   ....*....|....*....|....*....|....
gi 71995462    211 QCPPGEmWKCGSGECIPSRWRCDAEVDCKDHSDE 244
Cdd:smart00192   1 TCPPGE-FQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 259-290 1.55e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 45.28  E-value: 1.55e-06
                        10        20        30
                ....*....|....*....|....*....|..
gi 71995462 259 EFACKaSHNCINKAFVCDGELDCSDGSDEDDC 290
Cdd:cd00112   5 EFRCA-NGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 120-159 1.77e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 45.28  E-value: 1.77e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 71995462 120 CQEKQFQCeelsgDYSLCIPETWVCDGQRDCTNGKDEQNC 159
Cdd:cd00112   1 CPPNEFRC-----ANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 581-621 4.07e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 44.46  E-value: 4.07e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 71995462   581 DLLFWTDGGLDQ-INVLDMKNGKQRVLYSSDLEEPRAIAVDP 621
Cdd:pfam00058   1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
571-676 5.21e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 48.92  E-value: 5.21e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71995462 571 PDGLAVDWVHDLLFWTDGGLDQINVLDMKNGKqrVLYSSDL-EEPRAIAVDPEVGLIFWTDWGkkarierSGM------- 642
Cdd:COG3391 112 PRGLAVDPDGGRLYVADSGNGRVSVIDTATGK--VVATIPVgAGPHGIAVDPDGKRLYVANSG-------SNTvsvivsv 182

                        90       100       110
                ....*....|....*....|....*....|....*
gi 71995462 643 -DGQHRTVIVEGDRVVWPNGLALDYVDKRVYWADA 676
Cdd:COG3391 183 iDTATGKVVATIPVGGGPVGVAVSPDGRRLYVANR 217
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 71-115 7.80e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 43.35  E-value: 7.80e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 71995462  71 CGAEEHKCGevksarssleRFKCIPNKWVCDGEFDCEDKSDEFQC 115
Cdd:cd00112   1 CPPNEFRCA----------NGRCIPSSWVCDGEDDCGDGSDEENC 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
431-461 1.58e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 1.58e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 71995462    431 DINECEIAGVCDQ--ICLNIPGSYRCACHAGYQ 461
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
118-159 2.88e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 41.85  E-value: 2.88e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 71995462   118 VSCQEKQFQCEElsgdySLCIPETWVCDGQRDCTNGKDEQNC 159
Cdd:pfam00057   1 STCSPNEFQCGS-----GECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 259-287 3.21e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 41.46  E-value: 3.21e-05
                           10        20
                   ....*....|....*....|....*....
gi 71995462    259 EFACKaSHNCINKAFVCDGELDCSDGSDE 287
Cdd:smart00192   6 EFQCD-NGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 120-156 3.21e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 41.46  E-value: 3.21e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 71995462    120 CQEKQFQCeelsgDYSLCIPETWVCDGQRDCTNGKDE 156
Cdd:smart00192   2 CPPGEFQC-----DNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
71-115 5.68e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 41.08  E-value: 5.68e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 71995462    71 CGAEEHKCGEVKsarsslerfkCIPNKWVCDGEFDCEDKSDEFQC 115
Cdd:pfam00057   3 CSPNEFQCGSGE----------CIPRSWVCDGDPDCGDGSDEENC 37
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 524-686 1.01e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 44.88  E-value: 1.01e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71995462 524 NGTLIWSDVLSKQILKCSIGnvsnaflgtdmcDKKHEIVLTGDkiHTPDGLAVDwvhdllfwTDGGL------DQINVLD 597
Cdd:COG3386  18 DGRLYWVDIPGGRIHRYDPD------------GGAVEVFAEPS--GRPNGLAFD--------PDGRLlvadhgRGLVRFD 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71995462 598 MKNGKQRVLYSS-DLEEPRA--IAVDPEvGLIFWTDWGKKA------RIERsgmDGQHRTVIvegDRVVWPNGLALDYVD 668
Cdd:COG3386  76 PADGEVTVLADEyGKPLNRPndGVVDPD-GRLYFTDMGEYLptgalyRVDP---DGSLRVLA---DGLTFPNGIAFSPDG 148

                       170
                ....*....|....*...
gi 71995462 669 KRVYWADAKIKSIFSCDY 686
Cdd:COG3386 149 RTLYVADTGAGRIYRFDL 166
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 431-461 1.06e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.06e-04
                        10        20        30
                ....*....|....*....|....*....|...
gi 71995462 431 DINECEIAGVCD--QICLNIPGSYRCACHAGYQ 461
Cdd:cd00054   1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYT 33
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 423-463 1.23e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 44.30  E-value: 1.23e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 71995462 423 KLENGQCIDINEC-EIAGVCDQICLNIPGSYRCACHAGYQIS 463
Cdd:cd01475 178 KFQGKICVVPDLCaTLSHVCQQVCISTPGSYLCACTEGYALL 219
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 92-112 1.54e-04

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 39.54  E-value: 1.54e-04
                           10        20
                   ....*....|....*....|.
gi 71995462     92 KCIPNKWVCDGEFDCEDKSDE 112
Cdd:smart00192  13 RCIPSSWVCDGVDDCGDGSDE 33
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
580-718 1.66e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 44.30  E-value: 1.66e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71995462 580 HDLLFWTDGGLDQINVLDMKNGK-QRVLYSSDleEPRAIAVDPEVGLIFWTDWGKKARIERSGMDGQHRTVIVEGDrvvW 658
Cdd:COG3391  79 GRRLYVANSGSGRVSVIDLATGKvVATIPVGG--GPRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPVGA---G 153

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71995462 659 PNGLALDYVDKRVYWAD------AKIKSIFscdywgkNIKT--VLHSHQYLRHPFSMAVFED--RLFYTD 718
Cdd:COG3391 154 PHGIAVDPDGKRLYVANsgsntvSVIVSVI-------DTATgkVVATIPVGGGPVGVAVSPDgrRLYVAN 216
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 490-677 2.50e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 43.73  E-value: 2.50e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71995462 490 TNRHTIRQFDLVNKMHFPVS-------SSPgSAVAMDfhiLNGTLIWSDVLSKQILKCSIGNVSNAFLGTDMCDKKheiv 562
Cdd:cd14962  30 TGRGAVFVFDLPNGKVFVIGnagpnrfVSP-IGVAID---ANGNLYVSDAELGKVFVFDRDGKFLRAIGAGALFKR---- 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71995462 563 ltgdkihtPDGLAVDWVHDLLFWTDGGLDQINVLDMKNGKQRVLYSSDLEE-----PRAIAVDPEvGLIFWTDWGkKARI 637
Cdd:cd14962 102 --------PTGIAVDPAGKRLYVVDTLAHKVKVFDLDGRLLFDIGKRGSGPgefnlPTDLAVDRD-GNLYVTDTM-NFRV 171

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 71995462 638 ERSGMDGQHRTVIVE-GDRV---VWPNGLALDYvDKRVYWADAK 677
Cdd:cd14962 172 QIFDADGKFLRSFGErGDGPgsfARPKGIAVDS-EGNIYVVDAA 214
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
253-290 3.17e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 38.77  E-value: 3.17e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 71995462   253 TCKlAEEFACkASHNCINKAFVCDGELDCSDGSDEDDC 290
Cdd:pfam00057   2 TCS-PNEFQC-GSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 320-342 1.32e-03

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 37.19  E-value: 1.32e-03
                        10        20
                ....*....|....*....|...
gi 71995462 320 CIPASSWCNGEEDCPDGGDEKEC 342
Cdd:cd00112  13 CIPSSWVCDGEDDCGDGSDEENC 35
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 565-716 1.64e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 41.15  E-value: 1.64e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71995462 565 GDKIHTPDGLAVDwVHDLLFWTDGGLDQINVLDMKNGKQRVLYSS-----DLEEPRAIAVDPEvGLIFWTDWGKKaRIER 639
Cdd:cd05819  51 DGQFNEPAGVAVD-SDGNLYVADTGNHRIQKFDPDGNFLASFGGSgdgdgEFNGPRGIAVDSS-GNIYVADTGNH-RIQK 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71995462 640 SGMDGQHRTVIVEGDRVVW----PNGLALDyVDKRVYWADA---KIKSIfscDYWGKNIKTVLHSHQY---LRHPFSMAV 709
Cdd:cd05819 128 FDPDGEFLTTFGSGGSGPGqfngPTGVAVD-SDGNIYVADTgnhRIQVF---DPDGNFLTTFGSTGTGpgqFNYPTGIAV 203


                ....*..
gi 71995462 710 FEDRLFY 716
Cdd:cd05819 204 DSDGNIY 210
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
571-733 3.81e-03

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 40.39  E-value: 3.81e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71995462 571 PDGLAVDwvHD-LLFWTDGGLDQINVLDMKNGKQRVLYSSDLEEPRAIAVDPEvGLIFWTDWGKKA--RIERSgmDGQHR 647
Cdd:COG4257  19 PRDVAVD--PDgAVWFTDQGGGRIGRLDPATGEFTEYPLGGGSGPHGIAVDPD-GNLWFTDNGNNRigRIDPK--TGEIT 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71995462 648 TVIVEGDRVVwPNGLALDyVDKRVYWADAKIKSIFSCDYWGKNIKTVLHSHQYLRhPFSMAV-FEDRLFYTDWEHDGVIT 726
Cdd:COG4257  94 TFALPGGGSN-PHGIAFD-PDGNLWFTDQGGNRIGRLDPATGEVTEFPLPTGGAG-PYGIAVdPDGNLWVTDFGANAIGR 170


                ....*..
gi 71995462 727 VNKFTGA 733
Cdd:COG4257 171 IDPDTGT 177
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 441-463 4.44e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 35.68  E-value: 4.44e-03
                          10        20
                  ....*....|....*....|...
gi 71995462   441 CDQICLNIPGSYRCACHAGYQIS 463
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQ 30
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 694-734 9.39e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 34.88  E-value: 9.39e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 71995462    694 VLHSHQyLRHPFSMAV--FEDRLFYTDWEHDgVITVNKFTGAD 734
Cdd:smart00135   2 TLLSSG-LGHPNGLAVdwIEGRLYWTDWGLD-VIEVANLDGTN 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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