BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534635   143 SNEEFSDVILTVEDEKFYVLKQFLASHSSHFKTLFLRKcEEEAEKSEYTLQDINSIDFQNLLEVLHGEPAIDEETVQGIR 222
Cdd:pfam00651   6 EQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQ-ESESSVSEITLDDVSPEDFEALLEFMYTGKLISEENVDDLL 84

                          90       100
                  ....*....|....*....|...
gi 17534635   223 DLADKYDMPFPTRKCEEFLIDLS 245
Cdd:pfam00651  85 AAADKLQIPSLVDKCEEFLIKSL 107

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534635   143 SNEEFSDVILTVEDEKFYVLKQFLASHSSHFKTLFLRKcEEEAEKSEYTLQDINSIDFQNLLEVLHGEPAIDEETVQGIR 222
Cdd:pfam00651   6 EQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQ-ESESSVSEITLDDVSPEDFEALLEFMYTGKLISEENVDDLL 84

                          90       100
                  ....*....|....*....|...
gi 17534635   223 DLADKYDMPFPTRKCEEFLIDLS 245
Cdd:pfam00651  85 AAADKLQIPSLVDKCEEFLIKSL 107

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534635    149 DVILTVEDEKFYVLKQFLASHSSHFKTLFLrKCEEEAEKSEYTLQDINSIDFQNLLEVLH-GEPAIDEETVQGIRDLADK 227
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFS-SDFKESDKSEIYLDDVSPEDFRALLNFLYtGKLDLPEENVEELLELADY 79

                           90
                   ....*....|....*...
gi 17534635    228 YDMPFPTRKCEEFLIDLS 245
Cdd:smart00225  80 LQIPGLVELCEEFLLKLL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534635 150 VILTVEDEKFYVLKQFLASHSSHFKTLFLRKCeEEAEKSEYTLQDINSIDFQNLLEVLHGEPAI-DEETVQGIRDLADKY 228
Cdd:cd01165   1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGF-RESGQAEINLRDISPEDFRALLEFLYGGKRDlDASNLLELLEAANFL 79

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534635   143 SNEEFSDVILTVEDEKFYVLKQFLASHSSHFKTLFLRKcEEEAEKSEYTLQDINSIDFQNLLEVLHGEPAIDEETVQGIR 222
Cdd:pfam00651   6 EQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQ-ESESSVSEITLDDVSPEDFEALLEFMYTGKLISEENVDDLL 84

                          90       100
                  ....*....|....*....|...
gi 17534635   223 DLADKYDMPFPTRKCEEFLIDLS 245
Cdd:pfam00651  85 AAADKLQIPSLVDKCEEFLIKSL 107

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534635    149 DVILTVEDEKFYVLKQFLASHSSHFKTLFLrKCEEEAEKSEYTLQDINSIDFQNLLEVLH-GEPAIDEETVQGIRDLADK 227
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFS-SDFKESDKSEIYLDDVSPEDFRALLNFLYtGKLDLPEENVEELLELADY 79

                           90
                   ....*....|....*...
gi 17534635    228 YDMPFPTRKCEEFLIDLS 245
Cdd:smart00225  80 LQIPGLVELCEEFLLKLL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534635 150 VILTVEDEKFYVLKQFLASHSSHFKTLFLRKCeEEAEKSEYTLQDINSIDFQNLLEVLHGEPAI-DEETVQGIRDLADKY 228
Cdd:cd01165   1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGF-RESGQAEINLRDISPEDFRALLEFLYGGKRDlDASNLLELLEAANFL 79

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534635 144 NEEFSDVILTVEDEKFYVLKQFLASHSSHFKTLFLRKCEEEAEKSEYTLQ-DINSID-FQNLLEVL-HGEPAIDEETVQG 220
Cdd:cd18292  14 NEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDWWSESKQSEIELVeDPECAAvFEKFLRYLyTGQISVNLETALP 93

                        90       100
                ....*....|....*....|
gi 17534635 221 IRDLADKYDMPFPTRKCEEF 240
Cdd:cd18292  94 LLMLADKYNVTDLKQLCVDF 113

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534635 144 NEEFSDVILTVEDEKFYVLKQFLASHSSHFKTLFLRKCEEEAEKsEYTLQDINSIDFQNLLEVLH-GEPAIDEETVQGIR 222
Cdd:cd18314   3 DSEFSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLK-EVTLEDVEPEIFETVLKYMYtGQVTLSEENVLDLL 81

                ....*....
gi 17534635 223 DLADKYDMP 231
Cdd:cd18314  82 MLASKYQVP 90

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534635 147 FSDVILTVEDEKFYVLKQFLASHSSHFKTLF---LRKCEEEAekseYTLQDINSIDFQNLLEVLHGEP-AIDEETVQGIR 222
Cdd:cd18265  23 FTDVVLLVDGKDFPCHRATLSANSAYFRAMFgghLKESRQAV----VEIQKVSAAAMEVLLDYMYGGGlRIQEDNVESVL 98

                        90
                ....*....|....*....
gi 17534635 223 DLADKYDMPFPTRKCEEFL 241
Cdd:cd18265  99 EASDLLQVSKLREACVRFL 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534635 143 SNEEFSDV--ILTVEDEKFYVLKQFLASHSSHFKTLFLRKCEEEAEKSEYTLQDINSIDFQNLLEVLH-GEPAIDEETVQ 219
Cdd:cd18294  10 NNPEFSDVkfLVGPERQEIFAHKCILAARCEVFRAMFLTGPQKESTQSPLVLSDIEPEVFRAVLEFIYtNCVTLSNHTVI 89

                        90       100
                ....*....|....*....|..
gi 17534635 220 GIRDLADKYDMPFPTRKCEEFL 241
Cdd:cd18294  90 EVLAAAVEYGLDELRKLCERFI 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534635 129 LMGIPKKTLRTFDE--SNEEFSDVILTVE----DEKFYVLKQFLASHSSHFKTLF---LRKCeeeaEKSEYTLQDINSID 199
Cdd:cd18248   1 LEDHTKEAFQIMNElrLSQQLCDVTLKVKyqdpKEEFMAHKVVLASSSPYFKAMFtsgLREC----GMEVVPIEGVHPCV 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 17534635 200 FQNLLEVLH-GEPAIDEETVQGIRDLADKYDMPFPTRKCEEFLID 243
Cdd:cd18248  77 MSRLIEFAYtASISVGEKCVLHVLPGAVMYQMDSVVKACCDFLEQ 121

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534635 140 FDESNEEFSDVILTVEDEKFYVLKQFLASHSSHFKTL----FLRKCEEEAEKSEYTLQDINSIDFQNLLEVLHGEPA-ID 214
Cdd:cd18296  10 PPEQELSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALlrdhFAESEENNGSIPVVTLHDVSPEVFAIVLYYIYTDDTdLP 89

                        90       100       110
                ....*....|....*....|....*....|..
gi 17534635 215 EETVQGIRDLADKYDMPFPTRKCEEFLIDLSE 246
Cdd:cd18296  90 PENAYDVLYVADMYLLPGLKRLCGTVLAQSLD 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534635 144 NEEFSDVILTVEDEKFYVLKQFLASHSSHFKTLFLRKCeEEAEKSEYTLQDINSIDFQNLLEVLH-GEPAIDEETVQGIR 222
Cdd:cd18237  18 QKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNM-TESKSSEVELKDAEPDIIELLVEFAYtARISVNSNNVQSLL 96

                        90
                ....*....|....*....
gi 17534635 223 DLADKYDMPFPTRKCEEFL 241
Cdd:cd18237  97 DAANQYQIEPVKKMCVDFL 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with various functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). It contains an ankyrin repeat, BTB/POZ, and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534635 143 SNEEFSDVILTVEDEKFYVLKQFLASHSSHFKTLFLRKCEEEAEKSE-YTLQDINSIDFQNLLEVLHgepaideetvqgi 221
Cdd:cd18350  20 NNKEMSDVTFLVEGKLFYAHKVLLVTASNRFKSLLTNKSEQESQGSKtIEISDIKYHIFQMLMQYLY------------- 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 17534635 222 rdLADKYDMPFPTrkceeflidlseKSIKEKLKIAKQFQLEKLKMHC 268
Cdd:cd18350  87 --YGGTESMEIPI------------ADVLELLSAASLFQLDALQRHC 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534635 147 FSDVILTVEDEKFYVLKQFLASHSSHFKTLFLRKCEEEaEKSEYTLQDINSIDFQNLLEVLH-GEPAIDEETVQGIRDLA 225
Cdd:cd18340  27 FVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDLEES-KKREIVLEDVDPDVMGKILHYIYtSEIEITEQNVQDIFAAA 105

                        90
                ....*....|....*.
gi 17534635 226 DKYDMPFPTRKCEEFL 241
Cdd:cd18340 106 NMFQIPSIFTVCVSFL 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534635 144 NEEFSDVILTVEDEKFYVLKQFLASHSSHFKTLFLRKCEEEAEKsEYTLQDINSIDFQNLLEVLH-------------GE 210
Cdd:cd18280  11 SEEGADVTFNVDGEKFRAHKLVLAARSPVFRSMLFGPMREENEG-EIVIEDVEPPVFKALLHFIYkdelpddvepagsDS 89

                        90       100
                ....*....|....*....|....*...
gi 17534635 211 PAIDEETVQGIRDLADKYDMPFPTRKCE 238
Cdd:cd18280  90 SSLDTTMAQHLLAAADRYALERLRLLCE 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534635 145 EEFSDVILTVEDEKFYVLKQFLASHSSHFKTLFLRKceEEAEKSEYTLQDINSIDFQNLLEVLHGEPA-IDEETVQGIRD 223
Cdd:cd18209  16 GQLCDVLLIVGDQKFRAHKNVLAASSEYFQSLFTEK--ENESQSVFQLDFCEPDAFENVLNYIYSSSLfVEKSSLAAVQE 93

                        90
                ....*....|.
gi 17534635 224 LADKYDMPFPT 234
Cdd:cd18209  94 LGYSLGISFLT 104

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534635 144 NEEFSDVILTVED-EKFYVLKQFLASHSSHFKTLFLRKCEEEAEKseytlqDINSIDFQNLLEVLH-GEPAIDEETVQGI 221
Cdd:cd18299   9 SPSCADVVFILQGgVRIFAHRIVLAAASSVFADLFLMMTVVTLDS------DITPEAFRRVLEFLYtGVLDENEDDLKEL 82

                        90
                ....*....|
gi 17534635 222 RDLADKYDMP 231
Cdd:cd18299  83 KDAAELLELF 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534635 133 PKKTLRTFDESNE-----EFSDVILTVEDEKFYVLKQFLASHSSHFKTLFlrKCEE-EAEKSEYTLQDINSIDFQNLLE- 205
Cdd:cd18235   2 PQHTQKAFDVMNElrkqnLLCDVILVADGVEIPAHRVVLASCSPYFHAMF--TGDLsESRANRVTLQDVDGKALLLLIDy 79

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 17534635 206 VLHGEPAIDEETVQGIRDLADKYDMPFPTRKCEEFL 241
Cdd:cd18235  80 VYTAEIQVTEENVQVLLPAANLLQLTDVRDACCDFL 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534635 133 PKKTLRTFDESNEE--FSDVILTVEDEKFYVLKQFLASHSSHFKTLFlrkCEEEAEKSEyTLQDINSIDFQNLLEVLH-- 208
Cdd:cd18253   2 SESILQVFNEFRDSrlFTDVIICVEGREFPCHRAILSACSSYFRAMF---CNDHRESRE-MLVEINGILAEAMDCFLQyv 77

                        90       100       110
                ....*....|....*....|....*....|....*
gi 17534635 209 --GEPAIDEETVQGIRDLADKYDMPFPTRKCEEFL 241
Cdd:cd18253  78 ytGKVKITTENVQYLFETSSLFQISPLRDACAKFL 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534635 144 NEEFSDVILTVEDEKFYVLKQFLASHSSHFKTLFLRKCEEEAEKSeYTLQDINSIDFQNLLEVLH-GEPAIDEETVQGIR 222
Cdd:cd18306  15 NRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSSDSDGESILT-VKLDGLDPDAVEVLVNYAYtSRLEVPADLVKSVY 93

                        90       100
                ....*....|....*....|.
gi 17534635 223 DLADKYDMPFPTRKCEEFLID 243
Cdd:cd18306  94 SAAKKLKMDRVKKACGDFLLE 114

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534635 144 NEEFSDVILTVEDEKFYVLKQFLASHSSHFKTLfLRKCEEEAEKSEYTLQDINSIDFQNLLEVLHGePAIDEETVQGIRD 223
Cdd:cd18286  14 NGEDSDITIKVDGKTFKAHRCILCARSSYFAAM-LSGSWAESNSSEITLTGVSHAAVSFVLLFIYG-GVLDLPDDVNLGE 91

                ....*..
gi 17534635 224 LADKYDM 230
Cdd:cd18286  92 LLSLADM 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534635 144 NEEFSDVILTV----EDEKFYVLKQFLASHSSHFKTLFLRKCEEEaeKSEYTLQDINSIDFQNLLEVLH-GEPAIDEETV 218
Cdd:cd18282   4 NELMADVHFIVgppgGTQRIPAHKYVLATGSSVFYAMFYGGLAEN--KNEIEIPDVEPAAFLNLLRYLYcDEIDLEPDTV 81

                        90       100
                ....*....|....*....|...
gi 17534635 219 QGIRDLADKYDMPFPTRKCEEFL 241
Cdd:cd18282  82 LATLYAAKKYLVPHLARACVQFL 104