BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534245   140 SNKKFSDVILAIEDEKFYVLKKFLASHSTYFKTLLLGKFEEAERQEVKLQDIDSTDFQNLMEVLYGESAIDDGTIKGILE 219
Cdd:pfam00651   6 EQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKLISEENVDDLLA 85

                          90       100
                  ....*....|....*....|..
gi 17534245   220 LADMYDMPFPIRKCEEFLIDSS 241
Cdd:pfam00651  86 AADKLQIPSLVDKCEEFLIKSL 107

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534245   140 SNKKFSDVILAIEDEKFYVLKKFLASHSTYFKTLLLGKFEEAERQEVKLQDIDSTDFQNLMEVLYGESAIDDGTIKGILE 219
Cdd:pfam00651   6 EQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKLISEENVDDLLA 85

                          90       100
                  ....*....|....*....|..
gi 17534245   220 LADMYDMPFPIRKCEEFLIDSS 241
Cdd:pfam00651  86 AADKLQIPSLVDKCEEFLIKSL 107

meprin and TRAF homology;

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534245     10 LRHIFKNVTKWKTGEIFYSPDEEHFNVPWQMCIHRENGNMCVILCCLKVEEDRVPWKINFEYQLKIVNISGMSIVKAGNK 89
Cdd:smart00061   2 LSHTFKNVSRLEEGESYFSPSEEHFNIPWRLKIYRKNGFLSLYLHCEKEECDSRKWSIEAEFTLKLVSQNGKSLSKKDKH 81

                           90
                   ....*....|....
gi 17534245     90 ICTEKRRFVRRQFI 103
Cdd:smart00061  82 VFEKPSGWGFSKFI 95

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17534245 147 VILAIEDEKFYVLKKFLASHSTYFKTLLLGKFEEAERQEVKLQDIDSTDFQNLMEVLYGESAIDD-GTIKGILELADMY 224
Cdd:cd01165   1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGFRESGQAEINLRDISPEDFRALLEFLYGGKRDLDaSNLLELLEAANFL 79

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534245   140 SNKKFSDVILAIEDEKFYVLKKFLASHSTYFKTLLLGKFEEAERQEVKLQDIDSTDFQNLMEVLYGESAIDDGTIKGILE 219
Cdd:pfam00651   6 EQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKLISEENVDDLLA 85

                          90       100
                  ....*....|....*....|..
gi 17534245   220 LADMYDMPFPIRKCEEFLIDSS 241
Cdd:pfam00651  86 AADKLQIPSLVDKCEEFLIKSL 107

meprin and TRAF homology;

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534245     10 LRHIFKNVTKWKTGEIFYSPDEEHFNVPWQMCIHRENGNMCVILCCLKVEEDRVPWKINFEYQLKIVNISGMSIVKAGNK 89
Cdd:smart00061   2 LSHTFKNVSRLEEGESYFSPSEEHFNIPWRLKIYRKNGFLSLYLHCEKEECDSRKWSIEAEFTLKLVSQNGKSLSKKDKH 81

                           90
                   ....*....|....
gi 17534245     90 ICTEKRRFVRRQFI 103
Cdd:smart00061  82 VFEKPSGWGFSKFI 95

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17534245 147 VILAIEDEKFYVLKKFLASHSTYFKTLLLGKFEEAERQEVKLQDIDSTDFQNLMEVLYGESAIDD-GTIKGILELADMY 224
Cdd:cd01165   1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGFRESGQAEINLRDISPEDFRALLEFLYGGKRDLDaSNLLELLEAANFL 79

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534245 141 NKKFSDVILAIEDEKFYVLKKFLASHSTYFKTLLLGKFEEAERQEVKLQDIDSTDFQNLMEVLY-GE---SAIDDGTIKG 216
Cdd:cd18287  19 NEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQQSEIELKDTNAEAFKALLKYIYtGRltlTDLKEDVLLD 98

                        90
                ....*....|.
gi 17534245 217 ILELADMYDMP 227
Cdd:cd18287  99 VLGLAHQYGFE 109

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534245 140 SNKKFSDVILAIEDEKFYVLKKFLASHSTYFKTLLLGKFEEAERQEVKLQDIDSTDFQNLMEVLYGESA--IDDGTIKGI 217
Cdd:cd18300   5 NKGLFSDVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRESSAKEVELPGVSKETFLALLEYLYTDQApiLEDGDCVGL 84

                        90       100
                ....*....|....*....|...
gi 17534245 218 LELADMYDMPFPIRKCEEFLIDS 240
Cdd:cd18300  85 IVLANRLCLPRLVALCEQYIVKE 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534245 144 FSDVILAIEDEKFYVLKKFLASHSTYFKTLLLGKFEEAERQEVKLQDIDSTDFQNLMEVLY-GESAIDDGTIKGILELAD 222
Cdd:cd18256  20 FCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFIYtGVVEVTVSNVQELLVAAD 99

                        90       100
                ....*....|....*....|..
gi 17534245 223 MYDMPFPIRKCEEFL---IDSS 241
Cdd:cd18256 100 MLQLTEVVEICCEFLkgqLHPS 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534245 144 FSDVILAIEDEKFYVLKKFLASHSTYFKTLLLGKFEEAERQEVKLQDIDSTDFQNLMEVLYGES-AIDDGTIKGILELAD 222
Cdd:cd18265  23 FTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAAMEVLLDYMYGGGlRIQEDNVESVLEASD 102

                        90
                ....*....|....*
gi 17534245 223 MYDMPFPIRKCEEFL 237
Cdd:cd18265 103 LLQVSKLREACVRFL 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534245 132 KQLRSFdKSNKKFSDVILAIEDEKFYVLKKFLASHSTYFKTLLLGKFEEAERQEVKLQDIDSTDFQNLMEVLY-GESAID 210
Cdd:cd18270  15 EQLKFF-YEQQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQIIITYAYtGNLAIN 93

                        90       100
                ....*....|....*....|....*...
gi 17534245 211 DGTIKGILELADMYDMPFPIRKCEEFLI 238
Cdd:cd18270  94 DSTVEQLYETACFLQVEDVLQRCREYLI 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534245 141 NKKFSDVILAIEDEKFYVLKKFLASHSTYFKTLLLGKFEEAERQEVKLQDIDSTDFQNLMEVLY--GESAIDDGTIKgIL 218
Cdd:cd18297   9 NPEMSDVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDIRYDIFQLMMQYLYtgGVESLDVAQDD-AL 87

                        90       100
                ....*....|....*....|..
gi 17534245 219 EL---ADMYDMPFPIRKCEEFL 237
Cdd:cd18297  88 ELlraASFFQLDGLKRHCEILL 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534245 143 KFSDVILAIEDEKFYVLKKFLASHSTYFKTLLLGKFEEAERQEVKLQDIDSTDFQNLMEVLY-GESAIDDGTIKGILELA 221
Cdd:cd18340  26 KFVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDLEESKKREIVLEDVDPDVMGKILHYIYtSEIEITEQNVQDIFAAA 105

                        90
                ....*....|....*.
gi 17534245 222 DMYDMPFPIRKCEEFL 237
Cdd:cd18340 106 NMFQIPSIFTVCVSFL 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534245 132 KQLRSFdKSNKKFSDVILAIEDEKFYVLKKFLASHSTYFKTLLLGKFEEAERQEVKLQDIDSTDFQNLMEVLY-GESAID 210
Cdd:cd18268  12 RQLNSL-RQERILTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLKGIDSDVLDQIVDYVYtGEILIT 90

                        90       100
                ....*....|....*....|....*....
gi 17534245 211 DGTIKGILELADMYDMPFPIRKCEEFLID 239
Cdd:cd18268  91 RDNVLPLMEAASMLQYPKLFEACSLYLQD 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534245 139 KSNKKFSDVILAIEDEKFYVLKKFLASHSTYFKTLLLGKFEEAERQEVKLQDIDSTDFQNLMEVLY-GESAIDDGTIKGI 217
Cdd:cd18255  13 RAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSAKGLKHILDFAYtSELTLDLDCIQDV 92

                        90       100
                ....*....|....*....|
gi 17534245 218 LELADMYDMPFPIRKCEEFL 237
Cdd:cd18255  93 LGAAVHLQMLPVVELCEEFL 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534245 142 KKFSDVILAIEDEKFYVLKKFLASHSTYFKTLLLGKFEEAERQEVKLQDIDSTDFQNLMEVLY-GESAIDDGTIKGILEL 220
Cdd:cd18269  25 NKFVDCVLKIGDKEFPCHRLVLAACSPYFRAMFLSDLEESKKKEVVLEDVDPDVMGMILKYLYtSEIDLNDQNVQDIFAL 104

                        90
                ....*....|....*..
gi 17534245 221 ADMYDMPFPIRKCEEFL 237
Cdd:cd18269 105 ASRFQIPSIFTVCVSYL 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534245 139 KSNKKFSDVILAIEDEKFYVLKKFLASHSTYFKTLLLGKFEEAERQEVKLQDIDSTDFQNLMEVLY-GESAIDDGTIKGI 217
Cdd:cd18259  27 RSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVESISARVEIKDVDPAVMESLIDFAYtGKLTINQGNVEAL 106

                        90       100
                ....*....|....*....|.
gi 17534245 218 LELADMYDMPfPIRK-CEEFL 237
Cdd:cd18259 107 IRTSNRLQFP-TVRKvCSRYL 126

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534245 134 LRSFD--KSNKKFSDVILAIED--EKFYVLKKFLASHSTYFKTLLLGKFEEAERQEVKLQDIDSTDFQNLMEVLY-GESA 208
Cdd:cd18239  11 LQGFDqlRGEGLLCDVTLVPGDgdETFPVHRAMMASASDYFKAMFTGGMKEQELMCIKLHGVSKIGLKNIIDFIYtAKLS 90

                        90       100       110
                ....*....|....*....|....*....|
gi 17534245 209 IDDGTIKGILELADMYDMPFPIRKCEEFLI 238
Cdd:cd18239  91 LNMDNLQDTLEAASFLQILPVLDFCKVLLI 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534245 141 NKKFSDVILAIEDEKFYVLKKFLASHSTYFKTLLLGK-FEEAERQEVKLQDIDSTD--FQNLMEVLY-GESAIDDGTIKG 216
Cdd:cd18292  14 NEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDwWSESKQSEIELVEDPECAavFEKFLRYLYtGQISVNLETALP 93

                        90       100
                ....*....|....*....|
gi 17534245 217 ILELADMYDMPFPIRKCEEF 236
Cdd:cd18292  94 LLMLADKYNVTDLKQLCVDF 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534245 145 SDVILAIEDEKFYVLKKFLASHSTYFKTLLLGKFEEAERQEVKLQDIDSTDFQNLMEVLY-GESAIDDGTIKGILELADM 223
Cdd:cd18234   2 CDVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVREATEEEIKLKDVDPDALWTLVQYCYtGRLELKEDNVESLLATACL 81

                        90
                ....*....|....*
gi 17534245 224 YDMPFPIRKCEEFLI 238
Cdd:cd18234  82 LQLSEVVEACCGFLM 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534245 146 DVILAIEDEKFYVLKKFLASHSTYFKTLLLGKFEEAERQEVKLQDIDSTDFQNLMEVL-YGESAIDDGTIKGILELADMY 224
Cdd:cd18244  32 DVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFMyYGTIELSMLTVHEILQAAMYV 111

                        90
                ....*....|....
gi 17534245 225 DMPFPIRKCEEFLI 238
Cdd:cd18244 112 QLTEVVKFCCSFLL 125

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with various functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). It contains an ankyrin repeat, BTB/POZ, and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534245 140 SNKKFSDVILAIEDEKFYVLKKFLASHSTYFKTLLLGKFEEAER--QEVKLQDIDSTDFQNLMEVLY-GESAIDDGTIKG 216
Cdd:cd18350  20 NNKEMSDVTFLVEGKLFYAHKVLLVTASNRFKSLLTNKSEQESQgsKTIEISDIKYHIFQMLMQYLYyGGTESMEIPIAD 99

                        90       100
                ....*....|....*....|.
gi 17534245 217 ILEL---ADMYDMPFPIRKCE 234
Cdd:cd18350 100 VLELlsaASLFQLDALQRHCE 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534245 141 NKKFSDVILAIEDEKFYVLKKFLASHSTYFKTLLLGKFEEAERQEVKLQDIDSTDFQNLMEVLY-GESAIDDGTIKGILE 219
Cdd:cd18342  19 NSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYtGKAPNLDKMADDLLA 98

                        90
                ....*....|....*...
gi 17534245 220 LADMYDMPFPIRKCEEFL 237
Cdd:cd18342  99 AADKYALERLKVMCEDAL 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534245 141 NKKFSDVILAIEDEKFYVLKKFLASHSTYFKTLLLGKFEEAERQEVKLQDIDSTDFQNLMEVLY-GESAIDDGTIKGILE 219
Cdd:cd18279  15 NSRFTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYtGKAPNLDKMADDLLA 94

                        90       100
                ....*....|....*....|
gi 17534245 220 LADMYDMPFPIRKCEEFLID 239
Cdd:cd18279  95 AADKYALERLKVMCEDALCS 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534245 141 NKKFSDVILAIEDEKFYVLKKFLASHSTYFKTLLLGKFEEAERQEVKLQDIDSTDFQNLMEVLY-GESAIDDGTIKGILE 219
Cdd:cd18345  15 RSAFSDVTLCVGGREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITDVDHEVMREMLRFIYtGKAPNLDKMADDLLA 94

                        90
                ....*....|....*...
gi 17534245 220 LADMYDMPFPIRKCEEFL 237
Cdd:cd18345  95 AADKYALERLKVMCEEAL 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534245 142 KKFSDVILAIEDEKFYVLKKFLASHSTYFKTLLLGKFEEAERQEVKLQDIDSTDFQNLMEVLYGESA-IDDGTIKGILEL 220
Cdd:cd18236  22 NSLTDVILCVDSQEFSCHRVVLAAASNYFRAMFCNDLKEKYEEKIIIKGVDAETMQILLDYTYTSKVlITKQNVQRVLEA 101

                        90       100
                ....*....|....*....|
gi 17534245 221 ADMYDMPFPIRKCEEFLIDS 240
Cdd:cd18236 102 ASLFQFLRMVDACASFLTEA 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534245 140 SNKKFSDVILAIEDEKFYVLKKFLASHSTYFKTLLLGKFEEAERQEVKLQDIDSTDFQNLMEVLY-GESAIDDGTIKGIL 218
Cdd:cd18238  11 ENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDIDEEAVELLVDFAYtGKLTLTVDNVQSLL 90

                        90
                ....*....|....*....
gi 17534245 219 ELADMYDMPFPIRKCEEFL 237
Cdd:cd18238  91 YAASLLQVEEVAKACCEFM 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534245 144 FSDVIL-AIEDEKFYVLKKFLASHSTYFKTLLLGKFEEAERQEVKLQDIDSTDFQNLMEVLY-GESAIDDGTIKGILELA 221
Cdd:cd18252  21 FTDITLqCASGQIFHCHKAALAACSSYFKVMFTADMKEKSNNVIKLSGIDHDILEALVNYVYtSQICITERNVQSLLEAA 100

                        90
                ....*....|....*..
gi 17534245 222 DMYDMPFPIRKCEEFLI 238
Cdd:cd18252 101 DLLQFISVKKACEQFLV 117