NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|17534863|ref|NP_493902|]
View 

BTB domain-containing protein [Caenorhabditis elegans]

Protein Classification

BTB/POZ domain-containing protein( domain architecture ID 10459331)

BTB (BR-C, ttk and bab)/POZ (Pox virus and Zinc finger) domain-containing protein similar to Arabidopsis thaliana BTB/POZ domain-containing proteins

Gene Ontology:  GO:0005515
PubMed:  27521773|17120193

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
131-233 4.33e-21

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


:

Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 85.77  E-value: 4.33e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534863   131 YDTMFEPSRKHDAVLLIGEKKLHVNKAFLSYHSDYFCDLFAEKFDEKNG--IPIENVTYENFGLLMSIIYPEAAFSnHQN 208
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVseITLDDVSPEDFEALLEFMYTGKLIS-EEN 79
                          90       100
                  ....*....|....*....|....*
gi 17534863   209 AEVLLELGNRFKIPAVMRHVENQII 233
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLI 104
 
Name Accession Description Interval E-value
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
131-233 4.33e-21

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 85.77  E-value: 4.33e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534863   131 YDTMFEPSRKHDAVLLIGEKKLHVNKAFLSYHSDYFCDLFAEKFDEKNG--IPIENVTYENFGLLMSIIYPEAAFSnHQN 208
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVseITLDDVSPEDFEALLEFMYTGKLIS-EEN 79
                          90       100
                  ....*....|....*....|....*
gi 17534863   209 AEVLLELGNRFKIPAVMRHVENQII 233
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLI 104
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
142-236 3.54e-19

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 80.43  E-value: 3.54e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534863    142 DAVLLIGEKKLHVNKAFLSYHSDYFCDLFAEKFDE--KNGIPIENVTYENFGLLMSIIYPEAAFSNHQNAEVLLELGNRF 219
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKEsdKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80
                           90
                   ....*....|....*..
gi 17534863    220 KIPAVMRHVENQIIRDT 236
Cdd:smart00225  81 QIPGLVELCEEFLLKLL 97
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
142-219 1.96e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 53.33  E-value: 1.96e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534863 142 DAVLLIGEKKLHVNKAFLSYHSDYFCDLFAEKFDEKNG--IPIENVTYENFGLLMSIIYPEAAFSNHQNAEVLLELGNRF 219
Cdd:cd18186   3 DVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSseIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAADKL 82
 
Name Accession Description Interval E-value
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
131-233 4.33e-21

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 85.77  E-value: 4.33e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534863   131 YDTMFEPSRKHDAVLLIGEKKLHVNKAFLSYHSDYFCDLFAEKFDEKNG--IPIENVTYENFGLLMSIIYPEAAFSnHQN 208
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVseITLDDVSPEDFEALLEFMYTGKLIS-EEN 79
                          90       100
                  ....*....|....*....|....*
gi 17534863   209 AEVLLELGNRFKIPAVMRHVENQII 233
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLI 104
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
142-236 3.54e-19

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 80.43  E-value: 3.54e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534863    142 DAVLLIGEKKLHVNKAFLSYHSDYFCDLFAEKFDE--KNGIPIENVTYENFGLLMSIIYPEAAFSNHQNAEVLLELGNRF 219
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKEsdKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80
                           90
                   ....*....|....*..
gi 17534863    220 KIPAVMRHVENQIIRDT 236
Cdd:smart00225  81 QIPGLVELCEEFLLKLL 97
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
142-219 1.96e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 53.33  E-value: 1.96e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534863 142 DAVLLIGEKKLHVNKAFLSYHSDYFCDLFAEKFDEKNG--IPIENVTYENFGLLMSIIYPEAAFSNHQNAEVLLELGNRF 219
Cdd:cd18186   3 DVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSseIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAADKL 82
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
144-219 1.53e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 50.74  E-value: 1.53e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17534863 144 VLLIGEKKLHVNKAFLSYHSDYFCDLFAEKFDE--KNGIPIENVTYENFGLLMSIIYPEAAFSNHQNAEVLLELGNRF 219
Cdd:cd01165   2 VLVVEGEKFHVNKELLAQSSEYFRALFRGGFREsgQAEINLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAANFL 79
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
156-230 8.30e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 44.19  E-value: 8.30e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534863 156 KAFLSYHSDYFCDLFAEKFDEKNG--IPIENVTYENFGLLMSIIY---PEAAFSNHQNAEVLLELGNRFKIPAVMRHVEN 230
Cdd:cd18297  28 KIVLVTASDRFKSMLSSGSTEAQTpvIEIPDIRYDIFQLMMQYLYtggVESLDVAQDDALELLRAASFFQLDGLKRHCEI 107
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
142-232 4.36e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 42.45  E-value: 4.36e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534863 142 DAVLLIGEKKLHVNKAFLSYHSDYFCDLFAEKFDE--KNGIPIENVTYENFGLLMSIIYPEAAFSNHQNAEVLLELGNRF 219
Cdd:cd18265  25 DVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKEsrQAVVEIQKVSAAAMEVLLDYMYGGGLRIQEDNVESVLEASDLL 104
                        90
                ....*....|....*..
gi 17534863 220 KIP----AVMRHVENQI 232
Cdd:cd18265 105 QVSklreACVRFLEGQL 121
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
142-226 1.37e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 40.60  E-value: 1.37e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534863 142 DAVLLIGEKKLHVNKAFLSYHSDYFCDLFAEKFDEKNGIPIE--NVTYENFGLLMSIIYPEAAFSNHQNAEVLLELGNRF 219
Cdd:cd18257  20 DVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSEKENSEVEfqCIDETALQAIVEYAYTGTVFISQATVESLLPAANLL 99

                ....*..
gi 17534863 220 KIPAVMR 226
Cdd:cd18257 100 QIKLVLK 106
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
142-224 5.69e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 38.98  E-value: 5.69e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534863 142 DAVLLIGEKKLHVNKAFLSYHSDYFCDLFAEKFDEKNG--IPIENVTYENFGLLMSIIYPEAAFSNHQNAEVLLELGNRF 219
Cdd:cd18250  23 DVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRAdrVVLHGVSAEILGLLLDFSYTGRVTVTQDNVEALLRAADLF 102

                ....*
gi 17534863 220 KIPAV 224
Cdd:cd18250 103 QFPSV 107
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
128-233 5.78e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 38.82  E-value: 5.78e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534863 128 VRSYDTMFEPSRK---HDAVLLIGEKKLHVNKAFLSYHSDYFCDL----FAEKFDEKNGIP---IENVTYENFGLLMSII 197
Cdd:cd18296   2 VDLDELPFPPEQElsfPDVCFQVEGHRFPCHKAFFCGRSDYFKALlrdhFAESEENNGSIPvvtLHDVSPEVFAIVLYYI 81
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 17534863 198 YPEAAFSNHQNAEVLLELGNRFKIPAVMRHVENQII 233
Cdd:cd18296  82 YTDDTDLPPENAYDVLYVADMYLLPGLKRLCGTVLA 117
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
117-220 8.95e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 38.42  E-value: 8.95e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534863 117 PPQISHDLNPQVRSYDTMfepsrkhDAVLLIGEKKLHVNKAFLSYHSDYFCDLFAEKFDEKNG-----IPIENVTYENFG 191
Cdd:cd18258   1 PKEMLKELNQQRRAKEFT-------DLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSSRDSGGgekleLTMSNINADVLE 73
                        90       100
                ....*....|....*....|....*....
gi 17534863 192 LLMSIIYPEAAFSNHQNAEVLLELGNRFK 220
Cdd:cd18258  74 LLLEFVYTGSLIIDSANAKTLLEAANKFQ 102
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
142-235 1.02e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 38.23  E-value: 1.02e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534863 142 DAVLLIGEKKLHVNKAFLSYHSDYFCDLFAEKFDEKNG--IPIENVTYENFGLLMSIIYPEAAFSNHQNAEVLLELGNRF 219
Cdd:cd18352  15 DVTFLVEGRRFYAHRIALLASSDAFRAMFDGGYREKEArdIEIPNIRWEVFELMMRFIYTGSVDITNDIAKDLLRAADQY 94
                        90
                ....*....|....*.
gi 17534863 220 KIPAVMRHVENQIIRD 235
Cdd:cd18352  95 LLEGLKRLCEYTIAQD 110
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
126-221 1.16e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 38.06  E-value: 1.16e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534863 126 PQVRSYDTM---FEPSRKHDAVLLIGEKKLHVNKAFLSYHSDYFCDLFAEKFDE--KNGIPIENVTYENFGLLMSIIYPE 200
Cdd:cd18343   4 PECRLAEDLgnlWENSRFTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEEskKNRVEINDVDPEVFKEMMRFIYTG 83
                        90       100
                ....*....|....*....|.
gi 17534863 201 AAFSNHQNAEVLLELGNRFKI 221
Cdd:cd18343  84 KAPNLDKMADNLLAAADKYAL 104
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
142-224 1.19e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 38.16  E-value: 1.19e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534863 142 DAVLLIGEKKLHVNKAFLSYHSDYFCDLFAEKFDE--KNGIPIENVTYENFGLLMSIIYPEAAFSNHQNAEVLLELGNRF 219
Cdd:cd18269  29 DCVLKIGDKEFPCHRLVLAACSPYFRAMFLSDLEEskKKEVVLEDVDPDVMGMILKYLYTSEIDLNDQNVQDIFALASRF 108

                ....*
gi 17534863 220 KIPAV 224
Cdd:cd18269 109 QIPSI 113
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
133-231 1.39e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 37.85  E-value: 1.39e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534863 133 TMFEPSRKH----DAVLLIGEKKLHVNKAFLSYHSDYFCDLFAEKFDEKNGI-PIENVTYENFGLLMSIIYPEAAFSNHQ 207
Cdd:cd18212  12 TNFEEQRKKdflcDITLIVENVQFRAHKALLAASSEYFSMMFADEGEVGQSIyMLEGMVAETFGALLEFIYTGCLQVGEK 91
                        90       100
                ....*....|....*....|....
gi 17534863 208 NAEVLLELGNRFKIPAVMRHVENQ 231
Cdd:cd18212  92 SLEQILATAQFLKVNDLVKAYSDY 115
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
134-224 2.58e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 37.51  E-value: 2.58e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534863 134 MFEPSRKHDAVLLIGEKKLHVNKAFLSYHSDYFCDLFAEKFDE--KNGIPIENVTYENFGLLMSIIYPEAAFSNHQNAEV 211
Cdd:cd18340  21 LLDHNKFVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDLEEskKREIVLEDVDPDVMGKILHYIYTSEIEITEQNVQD 100
                        90
                ....*....|...
gi 17534863 212 LLELGNRFKIPAV 224
Cdd:cd18340 101 IFAAANMFQIPSI 113
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
126-221 3.60e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 37.00  E-value: 3.60e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534863 126 PQVRSYDTM---FEPSRKHDAVLLIGEKKLHVNKAFLSYHSDYFCDLFAEKFDE--KNGIPIENVTYENFGLLMSIIYPE 200
Cdd:cd18342   5 PECRLADELgglWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEEskKNRVEINDVEPEVFKEMMCFIYTG 84
                        90       100
                ....*....|....*....|.
gi 17534863 201 AAFSNHQNAEVLLELGNRFKI 221
Cdd:cd18342  85 KAPNLDKMADDLLAAADKYAL 105
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
142-232 4.32e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 36.73  E-value: 4.32e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534863 142 DAVLLIGEKKLHVNKAFLSYHSDYFCDLFAEKFDEKNG--IPIENVTYENFGLLMSIIYPEAAFSNHQNAEVLLELGNRF 219
Cdd:cd18259  34 DVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVESISarVEIKDVDPAVMESLIDFAYTGKLTINQGNVEALIRTSNRL 113
                        90
                ....*....|....*..
gi 17534863 220 KIPAVM----RHVENQI 232
Cdd:cd18259 114 QFPTVRkvcsRYLQQQI 130
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
142-228 4.80e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 36.45  E-value: 4.80e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534863 142 DAVLLIGEKKLHVNKAFLSYHSDYFCDLFAE--KFDEKNGIPIENVTYENFGLLMSIIYPEAAFSNHQNAEVLLELGNRF 219
Cdd:cd18326  27 DVVILVEGREFPTHRSVLAACSQYFKKLFTSgaVVDQQNVYEIDFVSAEALTALLDFAYTATLTVSTSNVGDILSAARLL 106

                ....*....
gi 17534863 220 KIPAVmRHV 228
Cdd:cd18326 107 EIPAV-SHV 114
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
142-224 5.33e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 36.36  E-value: 5.33e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534863 142 DAVLLIGEKKLHVNKAFLSYHSDYFCDLFAEKFDE--KNGIPIENVTYENFGLLMSIIYPEAAFSNHQNAEVLLELGNRF 219
Cdd:cd18341  29 DCTLKAGDKSLPCHRLILAACSPYFREYFLSEESEekKKEVVLDNVDPNIMDMILKYLYSAEIDLNDGNVQDIFALASRF 108

                ....*
gi 17534863 220 KIPAV 224
Cdd:cd18341 109 QIPSV 113
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
142-222 5.70e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 36.00  E-value: 5.70e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534863 142 DAVLLIGEKKLHVNKAFLSYHSDYFCDLFAEKFDEKNGI-PIENVTYENFGLLMSIIYPEAAFSNHQNAEVLLELGNRFK 220
Cdd:cd18209  20 DVLLIVGDQKFRAHKNVLAASSEYFQSLFTEKENESQSVfQLDFCEPDAFENVLNYIYSSSLFVEKSSLAAVQELGYSLG 99

                ..
gi 17534863 221 IP 222
Cdd:cd18209 100 IS 101
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
131-198 9.78e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 34.96  E-value: 9.78e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17534863 131 YDTMFEPSRKHDAVLLIGEKKLHVNKAFLSYHSDYFCDLFAE--KFDEKNGIP----IENVTYENFGLLMSIIY 198
Cdd:cd18301   9 LDEADEGDNIHDVVFQVGGKTFPAHKFILASRSDYFRKLFLSslLTSEDAVGCdvvhIEKVPPEIFEQLLQFIY 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH