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Conserved domains on  [gi|17534795|ref|NP_493701|]
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AB hydrolase-1 domain-containing protein [Caenorhabditis elegans]

Protein Classification

alpha/beta fold hydrolase( domain architecture ID 11426811)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

PubMed:  1409539|12369917

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
55-262 1.56e-17

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


:

Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 78.89  E-value: 1.56e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534795  55 DQVTIVGIDPPGYGTSRPPERKQEVQRCMKDseyCLGLMETLKLEPFTVMGWSEGARTTVHVAAKGKEKVNRMIVMAGAT 134
Cdd:COG0596  48 AGYRVIAPDLRGHGRSDKPAGGYTLDDLADD---LAALLDALGLERVVLVGHSMGGMVALELAARHPERVAGLVLVDEVL 124
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534795 135 KvnhlgamafkgmretnHWLAAGRQPyldHYSPETLRTQWAALcdvvdqvhsfcgGRFPCDLVLPQVKCPTLVMNGGLDR 214
Cdd:COG0596 125 A----------------ALAEPLRRP---GLAPEALAALLRAL------------ARTDLRERLARITVPTLVIWGEKDP 173
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 17534795 215 FCGDPNVCFIPVLKSLAKVEIHAQGGHDFYLKYPKWFSGKVLEFLKST 262
Cdd:COG0596 174 IVPPALARRLAELLPNAELVVLPGAGHFPPLEQPEAFAAALRDFLARL 221
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
55-262 1.56e-17

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 78.89  E-value: 1.56e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534795  55 DQVTIVGIDPPGYGTSRPPERKQEVQRCMKDseyCLGLMETLKLEPFTVMGWSEGARTTVHVAAKGKEKVNRMIVMAGAT 134
Cdd:COG0596  48 AGYRVIAPDLRGHGRSDKPAGGYTLDDLADD---LAALLDALGLERVVLVGHSMGGMVALELAARHPERVAGLVLVDEVL 124
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534795 135 KvnhlgamafkgmretnHWLAAGRQPyldHYSPETLRTQWAALcdvvdqvhsfcgGRFPCDLVLPQVKCPTLVMNGGLDR 214
Cdd:COG0596 125 A----------------ALAEPLRRP---GLAPEALAALLRAL------------ARTDLRERLARITVPTLVIWGEKDP 173
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 17534795 215 FCGDPNVCFIPVLKSLAKVEIHAQGGHDFYLKYPKWFSGKVLEFLKST 262
Cdd:COG0596 174 IVPPALARRLAELLPNAELVVLPGAGHFPPLEQPEAFAAALRDFLARL 221
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
47-132 1.27e-07

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 51.35  E-value: 1.27e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534795    47 KLLSHFPPDQVTIVGIDPPGYGTSRPPerkqevqrcMKDSEYCLG--------LMETLKLEPFTVMGWSEGARTTVHVAA 118
Cdd:pfam00561  18 KLAPALARDGFRVIALDLRGFGKSSRP---------KAQDDYRTDdlaedleyILEALGLEKVNLVGHSMGGLIALAYAA 88
                          90
                  ....*....|....
gi 17534795   119 KGKEKVNRMIVMAG 132
Cdd:pfam00561  89 KYPDRVKALVLLGA 102
PLN02980 PLN02980
2-oxoglutarate decarboxylase/ hydro-lyase/ magnesium ion binding / thiamin pyrophosphate ...
60-133 6.95e-03

2-oxoglutarate decarboxylase/ hydro-lyase/ magnesium ion binding / thiamin pyrophosphate binding


Pssm-ID: 215530 [Multi-domain]  Cd Length: 1655  Bit Score: 37.91  E-value: 6.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534795    60 VGIDPPGYGTSRpperkqeVQRCMKDS------------EYCLGLMETLKLEPFTVMGWSEGARTTVHVAAKGKEKVNRM 127
Cdd:PLN02980 1401 ISIDLPGHGGSK-------IQNHAKETqteptlsvelvaDLLYKLIEHITPGKVTLVGYSMGARIALYMALRFSDKIEGA 1473

                  ....*.
gi 17534795   128 IVMAGA 133
Cdd:PLN02980 1474 VIISGS 1479
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
55-262 1.56e-17

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 78.89  E-value: 1.56e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534795  55 DQVTIVGIDPPGYGTSRPPERKQEVQRCMKDseyCLGLMETLKLEPFTVMGWSEGARTTVHVAAKGKEKVNRMIVMAGAT 134
Cdd:COG0596  48 AGYRVIAPDLRGHGRSDKPAGGYTLDDLADD---LAALLDALGLERVVLVGHSMGGMVALELAARHPERVAGLVLVDEVL 124
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534795 135 KvnhlgamafkgmretnHWLAAGRQPyldHYSPETLRTQWAALcdvvdqvhsfcgGRFPCDLVLPQVKCPTLVMNGGLDR 214
Cdd:COG0596 125 A----------------ALAEPLRRP---GLAPEALAALLRAL------------ARTDLRERLARITVPTLVIWGEKDP 173
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 17534795 215 FCGDPNVCFIPVLKSLAKVEIHAQGGHDFYLKYPKWFSGKVLEFLKST 262
Cdd:COG0596 174 IVPPALARRLAELLPNAELVVLPGAGHFPPLEQPEAFAAALRDFLARL 221
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
47-132 1.27e-07

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 51.35  E-value: 1.27e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534795    47 KLLSHFPPDQVTIVGIDPPGYGTSRPPerkqevqrcMKDSEYCLG--------LMETLKLEPFTVMGWSEGARTTVHVAA 118
Cdd:pfam00561  18 KLAPALARDGFRVIALDLRGFGKSSRP---------KAQDDYRTDdlaedleyILEALGLEKVNLVGHSMGGLIALAYAA 88
                          90
                  ....*....|....
gi 17534795   119 KGKEKVNRMIVMAG 132
Cdd:pfam00561  89 KYPDRVKALVLLGA 102
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
58-261 3.66e-05

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 43.84  E-value: 3.66e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534795  58 TIVGIDPPGYGTS-RPPERKQEVQRCMKDSEYCLGLMETLKLEPFTVMGWSEGARTTVHVAAKGKEKVNRMIVMAGATKV 136
Cdd:COG2267  57 AVLAFDLRGHGRSdGPRGHVDSFDDYVDDLRAALDALRARPGLPVVLLGHSMGGLIALLYAARYPDRVAGLVLLAPAYRA 136
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534795 137 NHLgamafkgMRETNHWLAAGRqpyldhyspetlrtqwaalcdVVDQvhsfcggrfpcdlvLPQVKCPTLVMNGGLDRFc 216
Cdd:COG2267 137 DPL-------LGPSARWLRALR---------------------LAEA--------------LARIDVPVLVLHGGADRV- 173
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 17534795 217 GDPNVC--FIPVLKSLAKVEIHAQGGHDFYL-KYPKWFSGKVLEFLKS 261
Cdd:COG2267 174 VPPEAArrLAARLSPDVELVLLPGARHELLNePAREEVLAAILAWLER 221
PLN02980 PLN02980
2-oxoglutarate decarboxylase/ hydro-lyase/ magnesium ion binding / thiamin pyrophosphate ...
60-133 6.95e-03

2-oxoglutarate decarboxylase/ hydro-lyase/ magnesium ion binding / thiamin pyrophosphate binding


Pssm-ID: 215530 [Multi-domain]  Cd Length: 1655  Bit Score: 37.91  E-value: 6.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534795    60 VGIDPPGYGTSRpperkqeVQRCMKDS------------EYCLGLMETLKLEPFTVMGWSEGARTTVHVAAKGKEKVNRM 127
Cdd:PLN02980 1401 ISIDLPGHGGSK-------IQNHAKETqteptlsvelvaDLLYKLIEHITPGKVTLVGYSMGARIALYMALRFSDKIEGA 1473

                  ....*.
gi 17534795   128 IVMAGA 133
Cdd:PLN02980 1474 VIISGS 1479
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
58-213 7.89e-03

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 36.84  E-value: 7.89e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534795  58 TIVGIDPPGYGTSRPPERKQEVQRCMKDSEYclgLMETLKL--EPFTVMGWSEGARTTVHVAAKGKEkVNRMIVMAGATK 135
Cdd:COG1647  44 TVYAPRLPGHGTSPEDLLKTTWEDWLEDVEE---AYEILKAgyDKVIVIGLSMGGLLALLLAARYPD-VAGLVLLSPALK 119
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534795 136 VNHLGAMAFKGMRETNHWLAAG---------RQPYLDHYSPETLRTQWAALCDVVDQvhsfcggrfpcdlvLPQVKCPTL 206
Cdd:COG1647 120 IDDPSAPLLPLLKYLARSLRGIgsdiedpevAEYAYDRTPLRALAELQRLIREVRRD--------------LPKITAPTL 185

                ....*..
gi 17534795 207 VMNGGLD 213
Cdd:COG1647 186 IIQSRKD 192
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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