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Conserved domains on  [gi|71983744|ref|NP_493089|]
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Acyl_transf_3 domain-containing protein [Caenorhabditis elegans]

Protein Classification

acyltransferase family protein( domain architecture ID 15196437)

acyltransferase family protein, containing a SGNH/GDSL hydrolase domain, may catalyze the acylation of one of a variety of substrates such as peptidoglycans or sugars

EC:  2.3.1.-
Gene Ontology:  GO:0016747

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
OafA COG1835
Peptidoglycan/LPS O-acetylase OafA/YrhL, contains acyltransferase and SGNH-hydrolase domains ...
2-331 4.59e-40

Peptidoglycan/LPS O-acetylase OafA/YrhL, contains acyltransferase and SGNH-hydrolase domains [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 441440  Cd Length: 309  Bit Score: 149.02  E-value: 4.59e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983744   2 SVAAKPKRLDLQGIRGLAILSVLGFHFYP--------ALFPNGYLGVDQFFVLSGFLMCMLLKRAENEPTCTLITlFYSK 73
Cdd:COG1835   1 ASSSRRRLPSLDGLRGLAALLVVLYHAFLlfppgplgGLLSGGFLGVDVFFVLSGFLITRSLLRRLERGGFSLRR-FYLR 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983744  74 RFKRilplylliillsmislytIFPdtsietnqksamrALLFVsnapksvqddyftmLAravdIFTHTWSLSVEVQFYFL 153
Cdd:COG1835  80 RFLR------------------IYP-------------AYLVV--------------LL----LTGHLWSLSVELQFYLL 110
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983744 154 VPFIFLFAIKLSGKLQ--LAYYALTGLLSYAFFFFTPSNTSFNSVFARIWQFLIGMIVFLLSSHSKKSPEAeknieecnk 231
Cdd:COG1835 111 FPLLLLLLRRLRRRLLalLALLALASLLLLALLLTGDPSAAYFLTLTRLWEFLLGALLALLYRRLRRLRRL--------- 181
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983744 232 liedeenntqkaqkPSILHLISYFPLISIILICIIPYqlntDFVRPLVTLATGALMLISDSNL--ILSNKILTYIGDISY 309
Cdd:COG1835 182 --------------LALAGLALLLAALLLLDGAPFPG----FGLLPLLAALLVLAAAAGSGLLsrLLSSRPLVFLGDISY 243
                       330       340
                ....*....|....*....|..
gi 71983744 310 SLYLIHWPIYAYWKLAFDGDVN 331
Cdd:COG1835 244 SLYLWHWPVLVLLLALLGRLLG 265
SGNH pfam19040
SGNH domain (fused to AT3 domains); This entry include SGNH domains that are found fused to ...
427-667 1.27e-17

SGNH domain (fused to AT3 domains); This entry include SGNH domains that are found fused to membrane domains from the AT3 families pfam01757.


:

Pssm-ID: 436916  Cd Length: 245  Bit Score: 82.73  E-value: 1.27e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983744   427 AGPLEWCNHTslEPSGKYKIAVIGNSWAANHGALIHDECGRKANTILQGSAGTCEALYPTlIENAGCPQYFEDFQKRI-- 504
Cdd:pfam19040  10 GDPLGACRLG--DGAGPPSVLLWGDSHAAALAPGLDEAAKERGVSVLQITRSGCPPLLLR-LPDAACAAFNAAILEALal 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983744   505 NAEKPDYLFIISR--YISVGNPGNITNFEEDP------IYQTMKKQLLGLVASTRlKVYILDAVPRHDTYKTKLIARWLK 576
Cdd:pfam19040  87 LPSKPDTVVLAARwsLYLEGPAFNDEGIGRDLsntiaaFAAALRATVAALAAAGK-KVVLLGPVPEYVPRNARCLARAGG 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983744   577 EGVIPL------EIDKRlgqsnaqlidgssYELARRRYSQLVADCdGRCVLLDYKPDFYNSITESYrIFDDMGYsYFTSS 650
Cdd:pfam19040 166 LLRDPLcsipraEYRAR-------------NARVNAALDELAAKP-GKVRVIDPSPLFCDDGGRCS-ALDGTPL-YFDDN 229
                         250
                  ....*....|....*..
gi 71983744   651 qHLTPHGLEHIRHVWKD 667
Cdd:pfam19040 230 -HLSPAGARLLAPLFAP 245
 
Name Accession Description Interval E-value
OafA COG1835
Peptidoglycan/LPS O-acetylase OafA/YrhL, contains acyltransferase and SGNH-hydrolase domains ...
2-331 4.59e-40

Peptidoglycan/LPS O-acetylase OafA/YrhL, contains acyltransferase and SGNH-hydrolase domains [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441440  Cd Length: 309  Bit Score: 149.02  E-value: 4.59e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983744   2 SVAAKPKRLDLQGIRGLAILSVLGFHFYP--------ALFPNGYLGVDQFFVLSGFLMCMLLKRAENEPTCTLITlFYSK 73
Cdd:COG1835   1 ASSSRRRLPSLDGLRGLAALLVVLYHAFLlfppgplgGLLSGGFLGVDVFFVLSGFLITRSLLRRLERGGFSLRR-FYLR 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983744  74 RFKRilplylliillsmislytIFPdtsietnqksamrALLFVsnapksvqddyftmLAravdIFTHTWSLSVEVQFYFL 153
Cdd:COG1835  80 RFLR------------------IYP-------------AYLVV--------------LL----LTGHLWSLSVELQFYLL 110
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983744 154 VPFIFLFAIKLSGKLQ--LAYYALTGLLSYAFFFFTPSNTSFNSVFARIWQFLIGMIVFLLSSHSKKSPEAeknieecnk 231
Cdd:COG1835 111 FPLLLLLLRRLRRRLLalLALLALASLLLLALLLTGDPSAAYFLTLTRLWEFLLGALLALLYRRLRRLRRL--------- 181
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983744 232 liedeenntqkaqkPSILHLISYFPLISIILICIIPYqlntDFVRPLVTLATGALMLISDSNL--ILSNKILTYIGDISY 309
Cdd:COG1835 182 --------------LALAGLALLLAALLLLDGAPFPG----FGLLPLLAALLVLAAAAGSGLLsrLLSSRPLVFLGDISY 243
                       330       340
                ....*....|....*....|..
gi 71983744 310 SLYLIHWPIYAYWKLAFDGDVN 331
Cdd:COG1835 244 SLYLWHWPVLVLLLALLGRLLG 265
SGNH pfam19040
SGNH domain (fused to AT3 domains); This entry include SGNH domains that are found fused to ...
427-667 1.27e-17

SGNH domain (fused to AT3 domains); This entry include SGNH domains that are found fused to membrane domains from the AT3 families pfam01757.


Pssm-ID: 436916  Cd Length: 245  Bit Score: 82.73  E-value: 1.27e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983744   427 AGPLEWCNHTslEPSGKYKIAVIGNSWAANHGALIHDECGRKANTILQGSAGTCEALYPTlIENAGCPQYFEDFQKRI-- 504
Cdd:pfam19040  10 GDPLGACRLG--DGAGPPSVLLWGDSHAAALAPGLDEAAKERGVSVLQITRSGCPPLLLR-LPDAACAAFNAAILEALal 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983744   505 NAEKPDYLFIISR--YISVGNPGNITNFEEDP------IYQTMKKQLLGLVASTRlKVYILDAVPRHDTYKTKLIARWLK 576
Cdd:pfam19040  87 LPSKPDTVVLAARwsLYLEGPAFNDEGIGRDLsntiaaFAAALRATVAALAAAGK-KVVLLGPVPEYVPRNARCLARAGG 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983744   577 EGVIPL------EIDKRlgqsnaqlidgssYELARRRYSQLVADCdGRCVLLDYKPDFYNSITESYrIFDDMGYsYFTSS 650
Cdd:pfam19040 166 LLRDPLcsipraEYRAR-------------NARVNAALDELAAKP-GKVRVIDPSPLFCDDGGRCS-ALDGTPL-YFDDN 229
                         250
                  ....*....|....*..
gi 71983744   651 qHLTPHGLEHIRHVWKD 667
Cdd:pfam19040 230 -HLSPAGARLLAPLFAP 245
Acyl_transf_3 pfam01757
Acyltransferase family; This family includes a range of acyltransferase enzymes. This domain ...
9-327 8.58e-14

Acyltransferase family; This family includes a range of acyltransferase enzymes. This domain is found in a wide range of acyltransferase enzymes, including, mainly, bacterial proteins which catalyze the transfer of acyl groups, other than amino-acyl, from one compound to another, such as Glucans biosynthesis protein C (OPGC) or protein OatA from Listeria monocytogenes serovar 1/2a and Staphylococcus aureus, an integral membrane protein which is responsible for O-acetylation at the C6-hydroxyl group of N-acetylmuramyl residues, forming the corresponding N,6-O-diacetylmuramic acid of the peptidoglycan, a modification that determines lysozyme resistance. This domain is also present in eukaryotic proteins, namely O-acyltransferase like protein (OACYL) from mouse and RHY1 (Regulator of hypoxia-inducible factor 1) and NRF6 (Nose resistant to fluoxetine protein 6) from Caenorhabditis elegans.


Pssm-ID: 426413 [Multi-domain]  Cd Length: 330  Bit Score: 72.97  E-value: 8.58e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983744     9 RLDLQGIRGLAILSVLGFHFYPALFPNGYL----------------GVDQFFVLSGFLMCMLLKRAENEPTctlitlFYS 72
Cdd:pfam01757   1 IAYLDLLRGIAILLVVIGHVLLAFGYGGFGlplelallflvflgrfGVPLFFFISGYLLAALRRRRRSLFK------FIK 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983744    73 KRFKRILPLYLLIILLsmislYTIFPDTSIETNQKSAMRALLFVSNAPKSVqddyftmlaraVDIFTHTWSLSVEVQFYF 152
Cdd:pfam01757  75 KRLLRLLIPYLLWSLL-----YALLLLLVAGLSVGGALLLLLLLNNGPLFF-----------LGVNGHLWFLSALFVFYL 138
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983744   153 LVPFIFLFAIKLSGKLQLAYYALTGLLSY----AFFFFTPSNTSFNSVFARIWQFLIGMIVFLLsshskkspeaekniee 228
Cdd:pfam01757 139 LLPLLLRLLRKLKKSLLLLLLLLLLLLFLlyilILLVGVPFTVLVLFIFLYLPFFLLGALLARY---------------- 202
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983744   229 cNKLIEDEENNTQKAQKPSILHLISYFPLISIILICIIPYQLNTDFVRPLVTLATGALMLISD--SNLILSNKILTYIGD 306
Cdd:pfam01757 203 -RKRIRSKRLKLLIIILLALALLALILLLLFLFGLDPLALEFYGYPSLLLLLLGILLLLLLALllANLRSLRRLLSYLGK 281
                         330       340
                  ....*....|....*....|.
gi 71983744   307 ISYSLYLIHWPIYAYWKLAFD 327
Cdd:pfam01757 282 YSFGIYLIHPPILLLLGKLLG 302
 
Name Accession Description Interval E-value
OafA COG1835
Peptidoglycan/LPS O-acetylase OafA/YrhL, contains acyltransferase and SGNH-hydrolase domains ...
2-331 4.59e-40

Peptidoglycan/LPS O-acetylase OafA/YrhL, contains acyltransferase and SGNH-hydrolase domains [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441440  Cd Length: 309  Bit Score: 149.02  E-value: 4.59e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983744   2 SVAAKPKRLDLQGIRGLAILSVLGFHFYP--------ALFPNGYLGVDQFFVLSGFLMCMLLKRAENEPTCTLITlFYSK 73
Cdd:COG1835   1 ASSSRRRLPSLDGLRGLAALLVVLYHAFLlfppgplgGLLSGGFLGVDVFFVLSGFLITRSLLRRLERGGFSLRR-FYLR 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983744  74 RFKRilplylliillsmislytIFPdtsietnqksamrALLFVsnapksvqddyftmLAravdIFTHTWSLSVEVQFYFL 153
Cdd:COG1835  80 RFLR------------------IYP-------------AYLVV--------------LL----LTGHLWSLSVELQFYLL 110
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983744 154 VPFIFLFAIKLSGKLQ--LAYYALTGLLSYAFFFFTPSNTSFNSVFARIWQFLIGMIVFLLSSHSKKSPEAeknieecnk 231
Cdd:COG1835 111 FPLLLLLLRRLRRRLLalLALLALASLLLLALLLTGDPSAAYFLTLTRLWEFLLGALLALLYRRLRRLRRL--------- 181
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983744 232 liedeenntqkaqkPSILHLISYFPLISIILICIIPYqlntDFVRPLVTLATGALMLISDSNL--ILSNKILTYIGDISY 309
Cdd:COG1835 182 --------------LALAGLALLLAALLLLDGAPFPG----FGLLPLLAALLVLAAAAGSGLLsrLLSSRPLVFLGDISY 243
                       330       340
                ....*....|....*....|..
gi 71983744 310 SLYLIHWPIYAYWKLAFDGDVN 331
Cdd:COG1835 244 SLYLWHWPVLVLLLALLGRLLG 265
SGNH pfam19040
SGNH domain (fused to AT3 domains); This entry include SGNH domains that are found fused to ...
427-667 1.27e-17

SGNH domain (fused to AT3 domains); This entry include SGNH domains that are found fused to membrane domains from the AT3 families pfam01757.


Pssm-ID: 436916  Cd Length: 245  Bit Score: 82.73  E-value: 1.27e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983744   427 AGPLEWCNHTslEPSGKYKIAVIGNSWAANHGALIHDECGRKANTILQGSAGTCEALYPTlIENAGCPQYFEDFQKRI-- 504
Cdd:pfam19040  10 GDPLGACRLG--DGAGPPSVLLWGDSHAAALAPGLDEAAKERGVSVLQITRSGCPPLLLR-LPDAACAAFNAAILEALal 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983744   505 NAEKPDYLFIISR--YISVGNPGNITNFEEDP------IYQTMKKQLLGLVASTRlKVYILDAVPRHDTYKTKLIARWLK 576
Cdd:pfam19040  87 LPSKPDTVVLAARwsLYLEGPAFNDEGIGRDLsntiaaFAAALRATVAALAAAGK-KVVLLGPVPEYVPRNARCLARAGG 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983744   577 EGVIPL------EIDKRlgqsnaqlidgssYELARRRYSQLVADCdGRCVLLDYKPDFYNSITESYrIFDDMGYsYFTSS 650
Cdd:pfam19040 166 LLRDPLcsipraEYRAR-------------NARVNAALDELAAKP-GKVRVIDPSPLFCDDGGRCS-ALDGTPL-YFDDN 229
                         250
                  ....*....|....*..
gi 71983744   651 qHLTPHGLEHIRHVWKD 667
Cdd:pfam19040 230 -HLSPAGARLLAPLFAP 245
Acyl_transf_3 pfam01757
Acyltransferase family; This family includes a range of acyltransferase enzymes. This domain ...
9-327 8.58e-14

Acyltransferase family; This family includes a range of acyltransferase enzymes. This domain is found in a wide range of acyltransferase enzymes, including, mainly, bacterial proteins which catalyze the transfer of acyl groups, other than amino-acyl, from one compound to another, such as Glucans biosynthesis protein C (OPGC) or protein OatA from Listeria monocytogenes serovar 1/2a and Staphylococcus aureus, an integral membrane protein which is responsible for O-acetylation at the C6-hydroxyl group of N-acetylmuramyl residues, forming the corresponding N,6-O-diacetylmuramic acid of the peptidoglycan, a modification that determines lysozyme resistance. This domain is also present in eukaryotic proteins, namely O-acyltransferase like protein (OACYL) from mouse and RHY1 (Regulator of hypoxia-inducible factor 1) and NRF6 (Nose resistant to fluoxetine protein 6) from Caenorhabditis elegans.


Pssm-ID: 426413 [Multi-domain]  Cd Length: 330  Bit Score: 72.97  E-value: 8.58e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983744     9 RLDLQGIRGLAILSVLGFHFYPALFPNGYL----------------GVDQFFVLSGFLMCMLLKRAENEPTctlitlFYS 72
Cdd:pfam01757   1 IAYLDLLRGIAILLVVIGHVLLAFGYGGFGlplelallflvflgrfGVPLFFFISGYLLAALRRRRRSLFK------FIK 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983744    73 KRFKRILPLYLLIILLsmislYTIFPDTSIETNQKSAMRALLFVSNAPKSVqddyftmlaraVDIFTHTWSLSVEVQFYF 152
Cdd:pfam01757  75 KRLLRLLIPYLLWSLL-----YALLLLLVAGLSVGGALLLLLLLNNGPLFF-----------LGVNGHLWFLSALFVFYL 138
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983744   153 LVPFIFLFAIKLSGKLQLAYYALTGLLSY----AFFFFTPSNTSFNSVFARIWQFLIGMIVFLLsshskkspeaekniee 228
Cdd:pfam01757 139 LLPLLLRLLRKLKKSLLLLLLLLLLLLFLlyilILLVGVPFTVLVLFIFLYLPFFLLGALLARY---------------- 202
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71983744   229 cNKLIEDEENNTQKAQKPSILHLISYFPLISIILICIIPYQLNTDFVRPLVTLATGALMLISD--SNLILSNKILTYIGD 306
Cdd:pfam01757 203 -RKRIRSKRLKLLIIILLALALLALILLLLFLFGLDPLALEFYGYPSLLLLLLGILLLLLLALllANLRSLRRLLSYLGK 281
                         330       340
                  ....*....|....*....|.
gi 71983744   307 ISYSLYLIHWPIYAYWKLAFD 327
Cdd:pfam01757 282 YSFGIYLIHPPILLLLGKLLG 302
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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