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Conserved domains on  [gi|71991275|ref|NP_492976|]
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Phospholipid scramblase [Caenorhabditis elegans]

Protein Classification

phospholipid scramblase family protein( domain architecture ID 10510595)

phospholipid scramblase family protein similar to mammalian phospholipid scramblase and Saccharomyces cerevisiae altered inheritance rate of mitochondria protein 25

Gene Ontology:  GO:0017128
PubMed:  11487015|19010806

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Scramblase pfam03803
Scramblase; Scramblase is palmitoylated and contains a potential protein kinase C ...
51-280 1.86e-109

Scramblase; Scramblase is palmitoylated and contains a potential protein kinase C phosphorylation site. Scramblase exhibits Ca2+-activated phospholipid scrambling activity in vitro. There are also possible SH3 and WW binding motifs. Scramblase is involved in the redistribution of phospholipids after cell activation or injury.


:

Pssm-ID: 252175  Cd Length: 221  Bit Score: 316.22  E-value: 1.86e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991275    51 MPMP-PAIQGVPTGLEYLTYLDTIMVHQIKELIEIVTDWETKNKYVLKNANGEQCYYAFEESGCCERQCCGPQRGFVMHI 129
Cdd:pfam03803   1 MSGPgQPPANCPAGLEYLLQLDQILVHQQIEPLEVFTGFETANRYVVKNVNGQPLYYAMERSNCCARQCCGTHRPFVMRI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991275   130 VDNFKREVLTIKREFKccgggccgCLACIGCCQQECIIETPSMGVLGIIRQRCGCMSSNYDIMDGDGNVIFQIDGPCCCM 209
Cdd:pfam03803  81 TDNFGNEVMTLKRPFS--------CISCCPSCLQEQEIQAPPGTTIGEVLQTWHLWRPNYELQNADGNQVLSIFGPCFKC 152
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 71991275   210 LCgCQDKEFPIKTAnNGTVVGAITKKWGGCFREAFTDADTFAVNFPGDLDVKLKGVLIGATFLIDFMEFEQ 280
Cdd:pfam03803 153 DC-GGDWEFPVKTA-DGEVVGSISRNWPGLGREAFTDADTYVVRFPLDLDVKLKAVLLGAAFLIDFMYFER 221
 
Name Accession Description Interval E-value
Scramblase pfam03803
Scramblase; Scramblase is palmitoylated and contains a potential protein kinase C ...
51-280 1.86e-109

Scramblase; Scramblase is palmitoylated and contains a potential protein kinase C phosphorylation site. Scramblase exhibits Ca2+-activated phospholipid scrambling activity in vitro. There are also possible SH3 and WW binding motifs. Scramblase is involved in the redistribution of phospholipids after cell activation or injury.


Pssm-ID: 252175  Cd Length: 221  Bit Score: 316.22  E-value: 1.86e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991275    51 MPMP-PAIQGVPTGLEYLTYLDTIMVHQIKELIEIVTDWETKNKYVLKNANGEQCYYAFEESGCCERQCCGPQRGFVMHI 129
Cdd:pfam03803   1 MSGPgQPPANCPAGLEYLLQLDQILVHQQIEPLEVFTGFETANRYVVKNVNGQPLYYAMERSNCCARQCCGTHRPFVMRI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991275   130 VDNFKREVLTIKREFKccgggccgCLACIGCCQQECIIETPSMGVLGIIRQRCGCMSSNYDIMDGDGNVIFQIDGPCCCM 209
Cdd:pfam03803  81 TDNFGNEVMTLKRPFS--------CISCCPSCLQEQEIQAPPGTTIGEVLQTWHLWRPNYELQNADGNQVLSIFGPCFKC 152
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 71991275   210 LCgCQDKEFPIKTAnNGTVVGAITKKWGGCFREAFTDADTFAVNFPGDLDVKLKGVLIGATFLIDFMEFEQ 280
Cdd:pfam03803 153 DC-GGDWEFPVKTA-DGEVVGSISRNWPGLGREAFTDADTYVVRFPLDLDVKLKAVLLGAAFLIDFMYFER 221
 
Name Accession Description Interval E-value
Scramblase pfam03803
Scramblase; Scramblase is palmitoylated and contains a potential protein kinase C ...
51-280 1.86e-109

Scramblase; Scramblase is palmitoylated and contains a potential protein kinase C phosphorylation site. Scramblase exhibits Ca2+-activated phospholipid scrambling activity in vitro. There are also possible SH3 and WW binding motifs. Scramblase is involved in the redistribution of phospholipids after cell activation or injury.


Pssm-ID: 252175  Cd Length: 221  Bit Score: 316.22  E-value: 1.86e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991275    51 MPMP-PAIQGVPTGLEYLTYLDTIMVHQIKELIEIVTDWETKNKYVLKNANGEQCYYAFEESGCCERQCCGPQRGFVMHI 129
Cdd:pfam03803   1 MSGPgQPPANCPAGLEYLLQLDQILVHQQIEPLEVFTGFETANRYVVKNVNGQPLYYAMERSNCCARQCCGTHRPFVMRI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991275   130 VDNFKREVLTIKREFKccgggccgCLACIGCCQQECIIETPSMGVLGIIRQRCGCMSSNYDIMDGDGNVIFQIDGPCCCM 209
Cdd:pfam03803  81 TDNFGNEVMTLKRPFS--------CISCCPSCLQEQEIQAPPGTTIGEVLQTWHLWRPNYELQNADGNQVLSIFGPCFKC 152
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 71991275   210 LCgCQDKEFPIKTAnNGTVVGAITKKWGGCFREAFTDADTFAVNFPGDLDVKLKGVLIGATFLIDFMEFEQ 280
Cdd:pfam03803 153 DC-GGDWEFPVKTA-DGEVVGSISRNWPGLGREAFTDADTYVVRFPLDLDVKLKAVLLGAAFLIDFMYFER 221
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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