Serpentine Receptor, class T [Caenorhabditis elegans]
Protein Classification
serpentine receptor Srt family protein( domain architecture ID 37116)
serpentine receptor Srt (class T) family protein is a seven-transmembrane (7TM) G protein-coupled receptor involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||
| 7TM_GPCR_Srt super family | cl12383 | Serpentine type 7TM GPCR chemoreceptor Srt; Chemoreception is mediated in Caenorhabditis ... |
21-287 | 2.10e-15 | |||||
Serpentine type 7TM GPCR chemoreceptor Srt; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srt is a member of the Srg superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'. The actual alignment was detected with superfamily member pfam10321: Pssm-ID: 402096 Cd Length: 313 Bit Score: 75.33 E-value: 2.10e-15
|
|||||||||
| Name | Accession | Description | Interval | E-value | |||||
| 7TM_GPCR_Srt | pfam10321 | Serpentine type 7TM GPCR chemoreceptor Srt; Chemoreception is mediated in Caenorhabditis ... |
21-287 | 2.10e-15 | |||||
Serpentine type 7TM GPCR chemoreceptor Srt; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srt is a member of the Srg superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'. Pssm-ID: 402096 Cd Length: 313 Bit Score: 75.33 E-value: 2.10e-15
|
|||||||||
| 7tm_classA_rhodopsin-like | cd00637 | rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ... |
39-280 | 3.59e-05 | |||||
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections. Pssm-ID: 410626 [Multi-domain] Cd Length: 275 Bit Score: 44.59 E-value: 3.59e-05
|
|||||||||
| Name | Accession | Description | Interval | E-value | |||||
| 7TM_GPCR_Srt | pfam10321 | Serpentine type 7TM GPCR chemoreceptor Srt; Chemoreception is mediated in Caenorhabditis ... |
21-287 | 2.10e-15 | |||||
Serpentine type 7TM GPCR chemoreceptor Srt; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srt is a member of the Srg superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'. Pssm-ID: 402096 Cd Length: 313 Bit Score: 75.33 E-value: 2.10e-15
|
|||||||||
| 7tm_classA_rhodopsin-like | cd00637 | rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ... |
39-280 | 3.59e-05 | |||||
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections. Pssm-ID: 410626 [Multi-domain] Cd Length: 275 Bit Score: 44.59 E-value: 3.59e-05
|
|||||||||
| Blast search parameters | ||||
|
